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US20110171315 Oral recombinant helicobacter pylori vaccine and preparing method thereof  
The invention relates to a recombinant protein used for immunoprophylaxis of human Helicobacter pylori infection and a degradable slow-releasing microsphere-encapsulated oral vaccine preparation...
US20140037672 FUSION PROTEINS COMPRISING ANTIGENIC APOB-100 PROTEIN FRAGMENTS AND A PROTEIN CARRIER, RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR TREATMENT AND/OR PREVENTION OF ATHEROSCLEROSIS  
A fusion protein comprising an antigenic fragment of apoB-100 and a suitable carrier and related compositions methods and systems.
US20110223187 LIVE LISTERIA-BASED VACCINES FOR CENTRAL NERVOUS SYSTEM THERAPY  
This invention is directed to methods for treating a central nervous system (CNS) tumor or cancer using live Listeria-based recombinant vaccines.
US20130058969 CHLOROPLASTS ENGINEERED TO EXPRESS PHARMACEUTICAL PROTEINS  
Vaccines for conferring immunity in mammals to infective pathogens are provided, as well as vectors and methods for plastid transformation of plants to produce protective antigens and vaccines for...
US20110300206 VACCINES AGAINST CHLAMYDIAL INFECTION  
The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the...
US20110086059 NON-HEMOLYTIC CLYA FOR EXCRETION OF PROTEINS  
The disclosure below provides a protein export system utilizing non-hemolytic variants of HlyE family member proteins for efficiently producing recombinant protein from a host cell. In a preferred...
US20110300172 FUSION PROTEINS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR TREATMENT AND/OR PREVENTION OF ATHEROSCLEROSIS  
A fusion protein comprising an antigenic fragment of apoB-100 and a suitable carrier and related compositions methods and systems.
US20120045479 Dry Powder Formulations, Vaccines and Methods  
Respirable dry powder formulations comprise myo-inositol and leucine. Dry powder human papillomavirus (HPV) vaccine formulations comprise a least one HPV capsid protein and a carrier comprising...
US20110076323 VACCINE FOR ALZHEIMER'S DISEASE  
Compositions and methods for prevention and treatment of Alzheimer's disease utilize a combination of amyloid-beta protein or a fragment thereof and a heat shock protein or a fragment thereof.
US20110206717 NON-TYPHOIDAL SALMONELLA VACCINES  
OmpD of non-typhoidal Salmonella (NTS), e.g. as derivable from Salmonella Typhimurium, and immunogenic fragments thereof are proposed for use in treating or preventing NTS infection and/or...
US20110081369 IMMUNE MODULATION WITH DEATH RECEPTOR-INDUCED APOPTOSIS  
This invention provides chimeric proteins comprising an apoptosis-inducing molecule fused to a member of a binding pair that is capable of binding to a selected cell that expresses a death...
US20130149329 BROADLY PROTECTIVE SHIGELLA VACCINE BASED ON TYPE III SECRETION APPARATUS PROTEINS  
Broad-based, cross-protective, O-serotype independent vaccines against Shigella and related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS)...
US20120121640 OX40/TRAIL Fusion Proteins  
Fusion proteins which act on the OX40/TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, and...
US20140242107 Direct Protein Delivery with Engineered Microvesicles  
The present invention relates to direct protein delivery with engineered micro vesicles.
US20150150959 BACTERIAL BIOFILM MATRIX AS A PLATFORM FOR PROTEIN DELIVERY  
Some aspects of this disclosure provide engineered exopolysaccharide-associated proteins, engineered bacteria expressing such proteins, and engineered biofilms comprising such proteins. Some...
US20130039938 HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS  
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using...
US20100303849 Lipidated Vaccine against Dengue Virus Infection  
Disclosed are immunogenic composition, fusion proteins, and related methods for inducing immune response to dengue virus infection.
US20120064105 Engineered Type IV Pilin of Clostridium difficile  
The present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected...
US20110280902 COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS  
Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed...
US20130287810 VACCINE COMPOSITIONS AND USES THEREOF  
The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems...
US20110091493 VACCINE COMPOSITIONS AND USES THEREOF  
The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems...
US20130064867 NANOEMULSION RESPIRATORY SYNCYTIAL VIRUS (RSV) SUBUNIT VACCINE  
The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins...
US20130259887 REOVIRUS VACCINES AND METHODS OF USE THEREFOR  
The present invention provides for modified reoviruses that carry α-helical epitopes from a variety of pathogens, as well as methods of using such modified reoviruses to generate immune responses...
US20120219580 HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS PROTEIN VACCINE DERIVED FROM TRANSGENIC PLANT, AND PREPARING METHOD THEREOF  
The present invention relates to a method for producing transgenic plants, which involves producing hemagglutinin proteins of the H5N1 virus using a plant transformation recombinant vector,...
US20140227315 Novel Chimeric Proteins and Methods for Using The Same  
Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second...
US20120177657 FUSION PROTEINS COMPRISING CD4 MINIMAL MODULES AND METHODS OF USE THEREOF  
Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as...
US20130115239 PROSTATE CANCER DNA VACCINE  
The present invention concerns an (adjuvant) treatment or prevention option for the treatment and prevention of prostate cancer. In particular, it pertains to the provision of recombinant,...
US20110318379 Vaccine for Porcine Post-Weaning Diarrhea Caused by Enterotoxigenic Escherichia Coli  
Vaccines and methods for making and using the same. An example vaccine may be a vaccine against enterotoxigenic Escherichia coli. The vaccine may include an Escherichia coli strain. The...
US20130295128 CHIMERIC VACCINES  
The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen...
US20130156802 Cholera Toxin Chimera and its Use as a Staph Vaccine  
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of...
US20140205624 TETRAVALENT AND MIXED HEAD BIVALENT DENGUE VACCINE  
The present invention relates to immunogenic compositions and vaccines of flavivirus. In particular, the present invention relates to improved Dengue vaccines and the design and making of such...
US20100330105 Anticancer Combination Therapies  
Methods for treating or preventing hyperproliferating diseases, e.g., cancer, are described. A method may comprise administering to a subject in need thereof a therapeutically effective amount of...
US20130259891 USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE UNRESPONSIVENESS IN PARASITICALLY INFECTED INDIVIDUALS  
This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
US20140220067 LIVE ATTENUATED CHIMERIC PORCINE CIRCOVIRUS VACCINE  
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a...
US20110250224 ADJUVANT COMBINATIONS OF LIPOSOMES AND MYCOBACTERIAL LIPIDS FOR IMMUNIZATION COMPOSITIONS AND VACCINES  
The present invention provides a vaccine adjuvant consisting of a combination of a surfactant i.e. dimethyldeoctadecylammonium-bromide/chloride (DDA) and a lipid extract from Mycobacterium bovis...
US20130243805 Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection  
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well...
US20110104196 IMMUNOGENIC COMPOSITION AND METHOD OF DEVELOPING A VACCINE BASED ON FUSION PROTEIN  
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to HIV fusion protein. The present...
US20130129768 TREATMENT OR PREVENTION OF INFECTION  
The invention relates to a method of reducing the incidence or severity of a disease or condition in a subject, said disease or condition being one associated with the presence of a microbial...
US20110027304 YERSINIA PESTIS ANTIGENS, VACCINE COMPOSITIONS AND RELATED METHODS  
The present invention provides antigens and vaccines useful in prevention of infection by Yersinia pestis. The present invention provides pharmaceutical compositions of such antigens and/or...
US20140193362 YEAST-BASED COMPOSITIONS AND METHODS FOR THE TREATMENT OR PREVENTION OF HEPATITIS DELTA VIRUS INFECTION  
Disclosed are immunotherapeutic compositions and methods for preventing and/or treating hepatitis delta virus (HDV) infection, including yeast-based HDV immunotherapeutic compositions and methods...
US20130171185 NOROVIRUS DERIVED IMMUNOGENIC COMPOSITIONS AND METHODS  
The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a...
US20100322897 CHARACTERIZATION OF IL-17F AND IL-17R INTERACTIONS  
The invention is related to findings that IL-17F-mediated inflammation of airway passages may be mediated via signaling through IL-17R on the basolateral surface of human respiratory epithelial...
US20130266608 METHODS AND COMPOSITIONS TO PRODUCE VACCINES AGAINST SMALLPOX IN PLANTS  
Compositions and methods for producing plant-derived immunogenic compositions that confer immunity against smallpox in a subject are provided. Plants engineered to produce antigenic proteins as...
US20120269844 VACCINES FOR THE TREATMENT OF NEOPLASIAS FROM VIRAL CAPSIDS OF BIRNAVIRUS CONTAINING ANTIGENS OF THE HUMAN PAPILLOMAVIRUS  
The invention relates to therapeutic vaccines for the treatment of neoplasias caused by the human papillomavirus (HPV). In particular, the vaccines of the present invention are formed by chimeric...
US20120052082 CROSS-PROTECTIVE INFLUENZA VACCINE  
A cross-protective influenza virus vaccine has been designed based on the incorporation of the genetically engineered, highly conserved M2 influenza viral protein optionally in combination with an...
US20110097355 VIRUS-LIKE PARTICLES AS VACCINES FOR PARAMYXOVIRUS  
The invention provides expression vectors and virus-like particles (VLPs) containing Newcastle Disease Virus Sequences in combination with sequences encoding proteins of interest. The vectors are...
US20140120156 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20140004181 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20120156237 Novel Antitoxin and Vaccine Platform Based on Nodavirus VLPS  
Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided....
US20150110831 COMPOSITIONS AND METHODS  
The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or...

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