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US20150086565 CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
US20130115230 DELIVERY PROTEINS  
Disclosed herein are materials and methods related to vaccines. Materials and methods for delivery of a payload, e.g., an immunogen, to the reticuloendothelial system via non-circulating lymphoid...
US20110189208 TB VACCINE  
The invention relates to a vaccine useful in therapy and prevention of mycobacterial infections.
US20130183323 TARGETED ANTIBIOTIC AND ANTIMICROBIAL TREATMENTS FOR PERSONALIZED ADMINISTRATION  
A solution for the bottleneck issues in antibiotic treatment is to use novel antibiotic formulas with targeted delivery customized based on the nature of the infection and resistance profile of...
US20140308272 TREATMENT OF PRION PROTEIN RELATED DISEASES  
According to the present invention, treatment of prion protein related diseases, and in particular cancer tumours, is effected by providing to a subject in need thereof a therapeutically effective...
US20150071879 Stabilization of Aqueous Compositions of Proteins with Displacement Buffers  
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least...
US20110236314 METHOD OF DETECTION AND DIAGNOSIS OF ORAL AND NASOPHARYNGEAL CANCERS  
The present invention relates to cancer and in particular to oral and nasopharyngeal cancers. In particular, the present invention relates to a method of detection and diagnosis of oral squamous...
US20150147271 TARGETS FOR DIAGNOSIS, PROGNOSIS AND THERAPY OF ACUTE MYELOID LEUKEMIA AND MYELODYSPLASTIC SYNDROMES  
Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets.
US20120014942 METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES  
Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
US20130156702 METHODS FOR THE TREATMENT AND THE DIAGNOSIS OF CANCER  
The present invention relates to methods for the diagnostic and the staging of cancer such as liver cancer. The present invention also relates to methods for the treatment of cancer including...
US20110002918 METHODS OF TREATING DISEASED TISSUE  
Treatment protocols for severe psoriasis include administering biologics, stopping all administration of the biologics after the severity of the psoriasis has reduced and has reached an...
US20150132368 TARGETED PROTEIN REPLACEMENT FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS  
The present invention relates to compositions and methods for delivering lysosomal proteins. The compositions and methods described herein permit the targeted delivery of exogenous lysosomal...
US20150125384 MODULAR NANODEVICES FOR SMART ADAPTABLE VACCINES  
Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric...
US20130195794 CANCER VACCINE  
The disclosure relates to a vaccine including at least one adjuvant useful in the prevention and treatment of blood cancers, for example lymphoma, leukaemia or myeloma.
US20120141473 COMPOSITIONS AND METHODS FOR TREATING OSTEOLYTIC DISORDERS COMPRISING MMP-14 BINDING PROTEINS  
Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and...
US20130224191 NOTUM PROTEIN MODULATORS AND METHODS OF USE  
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
US20150218645 METHODS AND PRODUCTS RELATED TO TARGETED CANCER THERAPY  
The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of...
US20150232575 TREATMENT OF OCULAR DISEASES  
Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular...
US20130095105 Treatment of Ocular Disease  
Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular...
US20110318338 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20110229468 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20110229467 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20110217299 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20110212089 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20110206666 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20110206665 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20150238656 ORGAN/TISSUE DECELLULARIZATION, FRAMEWORK MAINTENANCE AND RECELLULARIZATION  
Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues,...
US20110305633 Methods for Treatment, the Prognostic Assessment and the Detection of Breast Cancer  
The present invention relates to methods for the treatment, the prognostic assessment and the detection of breast cancer.
US20130295043 VACCINATION IN ELDERLY PATIENTS  
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in an elderly patient preferably exhibiting an age of at...
US20100303723 DRUG DELIVERY SYSTEMS USING FC FRAGMENTS  
The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive...
US20140377286 DETECTION AND TREATMENT OF CD30+ CANCERS  
The application provides methods of diagnosis, prognosis, prophylaxis and treatment of CD30+ cancers.
US20140178377 METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTONIC DYSTROPHY  
In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy.
US20120009146 Treatment and Diagnostic Methods for Fibrosis Related Disorders  
The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods...
US20120058131 PTA089 PROTEIN  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, colorectal cancer, head and neck cancer, kidney cancer, liver cancer,...
US20110250215 STRUCTURALLY-RELATED RELAXIN-FUSION PROTEINS WITH EXTENDED IN VIVO HALF-LIVES  
Disclosed are human relaxin-Fc fusion proteins having an increased serum half-life, polynucleotides encoding the same, and intermediates formed during the fusion protein biosynthesis. The fusion...
US20110123591 TUMORICIDAL, BACTERICIDAL, OR VIRICIDAL MACROPHAGE ACTIVATION  
The activation of macrophages and methods for treating cancer, bacterial pathogens and viral pathogens are disclosed. In particular, Gc protein is converted to Gc-macrophage activating factor...
US20110305634 Methods and systems for adenovirus interaction with desmoglein 2 (DSG2)  
The present invention provides compositions and methods for treating disorders associated with epithelial tissues.
US20150247206 Compositions and Methods for Therapy and Diagnosis of Cancer and Cancer Metastasis  
The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer....
US20110206705 B7-H3 AS A BIOMARKER FOR DIAGNOSING THE PROGRESSION AND EARLY LYMPH NODE METASTASIS OF CANCER  
B7H3 is a ligand member of the immunoregulatory family of proteins on immune cells. In one embodiment, a method for diagnosing the progression of cancer with a high propensity of primary tumor...
US20130289520 TARGETED AND LIGHT-ACTIVATED CYTOSOLIC DRUG DELIVERY  
The present invention provides methods and compositions for highly precise spatial and temporal control over cytosolic delivery of compounds, in particular, those compounds that would otherwise be...
US20150093397 Methods for Increasing Efficacy of CD37-Based Therapy  
Methods to improve the success of cancer therapies that target CD37 are provided. Kits comprising reagent useful in the methods are further provided.
US20150104382 COMPOSITIONS AND METHODS FOR IDENTIFYING AND TARGETING CANCER CELLS OF ALIMENTARY CANAL ORIGIN  
Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
US20130230524 Protein Involved in Ovarian Cancer  
The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including...
US20110059088 Protein involved in ovarian cancer  
The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including...
US20120282175 Methods for Increasing Efficacy of FOLR1 Cancer Therapy  
Methods to improve the success of cancer therapies that target the human folate receptor 1 are provided. Kits comprising reagent useful in the methods are further provided.
US20130095065 Methods for Treating Vascular Leak Syndrome and Cancer  
Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer...
US20130071413 TARGETED IMMUNE CONJUGATES  
Disclosed herein are materials and methods related to vaccines. Materials and methods for delivery of immunogens to the reticuloendothelial system via non-circulating lymphoid cells are provided.
US20150182583 METHODS FOR TREATMENT AND PREVENTION OF TAUOPATHIES BY INHIBITING ENDOTHELIN RECEPTORS  
Compositions and methods of treatment of tauopathies are provided. In some embodiments, an antagonist of endothclin receptor A (ETA) and endothelin receptor B (ETB) may be administered to a...
US20110097392 ANTIBODY BOUND SYNTHETIC VESICLE CONTAINING MOLECULES FOR DELIVER TO CENTRAL AND PERIPHERAL NERVOUS SYSTEM CELLS  
A process is provided of delivering at least one active agent cargo molecule into an neuronal cell whereby a cargo molecule is placed within a synthetic vesicle such as a liposome and a...
US20120183543 DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS  
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention...