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US20130302320 Use of Semaphorin-4D Binding Molecules to Promote Neurogenesis Following Stroke  
Provided herein are methods for promoting neurogenesis in neural tissue of a patient exhibiting at least one symptom of a central nervous system disorder, the method comprising administering to a...
US20140010885 SELF-ASSEMBLING NANOPARTICLE DRUG DELIVERY SYSTEM  
A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The...
US20150071879 Stabilization of Aqueous Compositions of Proteins with Displacement Buffers  
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least...
US20120003243 YEAST ECTOPICALLY EXPRESSING ABNORMALLY PROCESSED PROTEINS AND USES THEREFOR  
Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast....
US20110212111 MHC II Associated Protein and Uses Thereof  
The present invention provides a MHC II associated protein, MPYS, and methods for using the same. In particular, the MHC II-associated protein of the present invention mediates apoptosis and...
US20130273067 Self-Buffering Protein Formulations  
The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering pharmaceutical protein formulations that are...
US20130273066 Self-Buffering Protein Formulations  
The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering pharmaceutical protein formulations that are...
US20110033547 DEHYDRATED CHITOSAN NANOPARTICLES  
The present invention relates to dehydrated nanoparticles comprising chitosan and a nucleic acid. Preferably, the nucleic acid is a siRNA. Dehydrated nanoparticles of the invention have improved...
US20110158993 Train-R: A Cysteine Rich Member of the TNF-Receptor Family  
Novel receptor in the TNF family: TRAIN-receptor.
US20110177096 USE OF GPR151 MODULATORS FOR THE TREATMENT OF PAIN  
The present invention relates to nucleic acid arrays used to detect genes which are up or down regulated following a pain stimulus in a mammal. It further relates to the use of GPR151 in methods...
US20140287024 NANOPARTICLE-BASED DELIVERY SYSTEM WITH OXIDIZED PHOSPHOLIPIDS AS TARGETING LIGANDS FOR THE PREVENTION, DIAGNOSIS AND TREATMENT OF ATHEROSCLEROSIS  
Disclosed are nanoparticle-based medicine/nutrient delivery system that are coated or incorporated with oxidized phospholipids as targeting ligands. Such delivery systems can specifically target...
US20120171225 Diagnostic Method for Predicting the Risk of Cancer Recurrence Based on Histone Macroh2A Isoforms  
The present invention relates to a method for diagnosing the risk of cancer recurrence in a mammalian patient, comprising detecting the expression of macroH2A1.1 and/or macroH2A2 in a biological...
US20130045180 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME  
Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines,...
US20120195852 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME  
Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines,...
US20130287794 METHODS FOR THE TREATMENT OR PREVENTION OF SYSTEMIC SCLEROSIS  
The invention is in the field of molecular immunology, more in particular, in the field of the prevention or treatment of autoimmune diseases, more in particular, systemic sclerosis or...
US20150044200 TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM  
The present invention relates to the treatment or prevention of tinnitus. More precisely, the present invention relates to a compound modulating chloride co-transporter NKCC1 (chloride...
US20120014942 METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF MALIGNANT DISEASES  
Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
US20130074201 CANCER-SPECIFIC GENETIC REARRANGEMENTS  
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating cancer characterized by the expression of...
US20120070379 IMMUNOTHERAPY REGIMES DEPENDENT ON APOE STATUS  
The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
US20150175703 EXTENDED TREATMENT OF MULTIPLE SCLEROSIS  
Methods for extended treatment of multiple sclerosis are described.
US20120276048 EXTENDED TREATMENT OF MULTIPLE SCLEROSIS  
Methods for extended treatment of multiple sclerosis are described.
US20150158940 USE OF ANTAGONISTS TARGETING METALLOTHIONEIN TO TREAT INTESTINAL INFLAMMATION  
Metallothioneins are stress inducible proteins with modulating functions during inflammation. Antagonizing metallothioneins during gut inflammation reduces markers of inflammations and enhances...
US20140363431 METHODS FOR TREATING PROGRESSIVE MULTIPLE SCLEROSIS  
The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.
US20140086872 Methods of Treating a Subject for a Condition  
Methods are provided for treating a subject for at least one condition that includes inflammation, a blood clotting condition and autonomic nervous system dysfunction such as adrenergia, e.g.,...
US20100310579 METHOD FOR INHIBITING ANGIOGENESIS OR FOR TREATMENT OF CANCER  
The invention concerns a method for inhibiting angiogenesis or for treating or preventing cancer or cancer metastasis in an individual. The method is based on the administration of an agent...
US20110243937 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20140010826 Use of DR6 and p75 Antagonists to Promote Survival of Cells of the Nervous System  
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating...
US20140044739 CDIM Binding Proteins And Uses Thereof  
The present disclosure relates to Cell Death Inducing Molecule (“CDIM”) binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that...
US20110212136 Nanosphere/Microsphere Delivery System for the Treatment of Spinal Cord Injury  
A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic...
US20120225085 DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
US20130034567 PROTEIN MODULATORS  
The present invention relates to modulators of the Neuregulin (NRG) family, particularly NRG1 and more particularly NRG1β, and most particularly NRG1β1. The present invention also relates to the...
US20140322237 NEURODEGENERATIVE DISEASES AND METHODS OF MODELING  
Disclosed are embryonic stem cells and motor neurons derived from mice carrying transgenic alleles of the normal or mutant human SOD1 gene. Also disclosed are in vitro systems employing such SOD1...
US20130225403 COMPOSITIONS FOR SEED TREATMENT  
Described is a composition for seed treatment comprising a plant seed-binding protein, preferably an antigen-binding plant seed-binding protein. In one embodiment, the seed-binding protein is...
US20120135009 Cleaved and Phosphorylated CRMP2 as Blood Marker of Inflammatory Diseases of the Central Nervous System  
The present invention relates to a method for in vitro prognosis, diagnosis and/or monitoring of an inflammatory disease of the central nervous system in a subject, said method comprising...
US20110008369 PD-1 BINDING PROTEINS  
The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through...
US20140147442 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION  
Methods and compositions comprising antagonists of IL-23 are provided for the treatment of infections, such as chronic bacterial, viral and fungal infections.
US20120328608 METHODS OF TREATING CANCER USING NOTCH ANTAGONISTS  
The present invention relates to methods of treating cancer in general, and leukemia in particular, using Notch1 and Notch3 antagonists singly or in combination. Compositions and methods for the...
US20120183562 SECRETED FXYD PROTEINS EXPRESSED IN RESPONSE TO EPITHELIAL TISSUE DAMAGE, AND USES THEREFOR  
Secreted FXYD family proteins are expressed by intestinal mucosa and/or associated tissues to regulate cell production in intestinal crypts in response to tissue damage. Such tissue damage may...
US20130017152 METHOD FOR THE TREATMENT OF MULTIPLE SCLEROSIS  
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to...
US20100303832 GENES AND POLYMORPHISMS ASSOCIATED WITH AMD  
The invention relates to genes, gene polymorphisms, and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as AMD. The...
US20110300161 Methods for the Treatment and the Prognostic Assessment of Malignant Pleural Mesothelioma  
The present invention relates to methods for the treatment and the prognostic assessment of malignant pleural mesothelioma.
US20150166667 METHODS AND COMPOSITIONS FOR TREATING CANCER  
The present invention generally concerns methods and compositions for treating skin hyperplasia and cancer.
US20150160230 METHODS OF PREDICTING AND DECREASING THE RISK OF PRE-TERM BIRTH  
Provided are methods for predicting the risk of pre-term birth in a pregnant subject, for identifying a subject having an increased risk of pre-term birth, for selecting a subject for...
US20130315922 METHOD FOR INDUCING LYMPHOID TISSUE AND MODULATING INTESTINAL HOMEOSTASIS  
Methods and products for modulating the lymphoid system, especially intestinal homeostasis between intestinal lymphoid tissues and gut flora using ligands for NOD1 and/or CCR6.
US20140193425 TREATMENT OF CANCER WITH ALK1 ANTAGONISTS  
Methods for evaluating responsiveness of a subject having cancer to treatment with an activin receptor-like kinase 1 (ALK1) antagonist are provided. Methods for selecting a subject for treatment...
US20120114596 TSLP PROMOTES IMMUNE EVASION AND PERSISTENCE OF VIRUSES  
It relates to the treatment or prevention of a chronic viral infection with a Thymic Stromal Lymphopoietin (TSLP) antagonist thereby avoiding immune evasion and persistence of the virus. It also...
US20110250212 THERAPY PROCEDURE FOR DRUG DELIVERY FOR TRIGEMINAL PAIN  
The present invention relates to methods for the treatment or prevention of trigeminal nerve-associated pain, in particular chronic, acute and procedural-related pain. The methods comprise...
US20120114663 METHODS TO TREAT ALLERGIC CONDITIONS  
Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are...
US20100297146 IMMUNE SYSTEM PROGRAMMING THROUGH B7-DC  
Materials and methods related to modulating immune responses (e.g., altering the polarity of immune responses) are provided.
US20110177094 IVIG MODULATION OF CHEMOKINES FOR TREATMENT OF MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, AND PARKINSON'S DISEASE  
The present invention provides methods for providing a prognosis of treatment of diseases associated with inflammatory disease of the brain, including MS, e.g., relapsing-remitting multiple...