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US20170094956 ANIMAL MODELS AND THERAPEUTIC MOLECULES  
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof...
US20120195899 Immunizing Compositions and Methods of Use  
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater...
US20100291100 Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions  
The present invention provides genes encoding novel microbial proteins (i.e., for example, exosporium genes and proteins) that mediate the attachment of microbial spores to surfaces. Specific...
US20070116698 Novel methods and medicament for treating infectious diseases involving microbial biofilms  
The present invention provides a method for prophylaxis and therapy of infectious diseases caused by microorganisms present in biofilms adherent to cell surfaces comprising the step of...
US20130045208 Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody  
The present invention relates to methods for the control of virulence of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. Derivatives of...
US20070189982 Diagnostics and treatments of Periodontal disease  
This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell association protein complex comprising the PrtR and PrtK proteins....
US20070009512 Recombinant bivalent monospecific immunoglobulin having at least two variable fragments of heavy chains of an immunoglobulin devoid of light chains  
The present invention relates to fragments, especially variable fragments of immunoglobulins which are by nature devoid of light chains, these fragments being nevertheless capable of exhibiting a...
US20070003560 Humanized monoclonal antibodies that protect against shiga toxin induced disease  
The present invention describes the preparation and use of biologically and immunologically active humanized monoclonal antibodies to Shiga toxin, a toxin associated with HC and the potentially...
US20120177650 THERAPY FOR ENTERIC INFECTIONS  
A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent with such infections or for preventing...
US20110200614 ANTHRAX SPECIFIC ANTIBODIES  
The present invention is directed to diagnostic tools and therapies using antibodies to Bacillus anthracis. Specifically, the present invention is directed to a B. anthracis-specific monoclonal...
US20100255002 Immunogenic compositions for chlamydia trachomatis  
The invention relates to compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. Specific combinations may be selected from a first antigen group of PepA,...
US20070224204 Combination therapy of respiratory diseases using antibodies and anti-inflammatory agents  
Therapeutically effective anti-viral compositions, useful especially against respiratory diseases caused or mediated by respiratory syncytial virus (RSV) are disclosed, wherein said compositions...
US20170105396 Animal Models and Therapeutic Molecules  
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof...
US20120189640 Methods and Compositions Related to Soluble Monoclonal Variable Lymphocyte Receptors of Defined Antigen Specificity  
Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal,...
US20070253964 Novel Immunogenic Compositions for the Prevention and Treatment of Meningococcal Disease  
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from neisserial strains or prepared recombinantly, including immunogenic...
US20060083746 Receptor for B. anthracis toxin  
The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the...
US20130243773 RECOMBINANT PRODUCTION OF MIXTURES OF ANTIBODIES  
Provided is methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy...
US20120177663 Therapeutic Monoclonal Antibodies that Neutralize Botulinum Neurotoxins  
This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof...
US20110081347 Antibodies with Altered Binding to FcRn and Methods of Using Same  
This invention relates to antibodies with altered binding to FcRn, and particularly antibodies having enhanced binding to FcRn and/or enhanced serum half-lives. The invention also relates to...
US20090136518 Compositions and methods to reduce mutagenesis  
The present invention provides methods and compositions for said inhibition of drug resistance. In one embodiment, said invention provides methods and compositions for said inhibition of...
US20080213285 SECRETED CHLAMYDIA POLYPEPTIDES, POLYNUCLEOTIDES CODING THEREFOR, THERAPEUTIC AND DIAGNOSTIC USES THEREOF  
The present invention relates to secreted Chlamydia polypeptides, which may be expressed by a Gram-negative bacterial strain and secreted by the type III secretion pathway of said bacterial...
US20080107652 Methods and compositions for control of disease in aquaculture  
The invention discloses paratransgenesis methods for prevention, amelioration or treatment of a disease or disorder in an aquatic animal. The method comprises providing a genetically modified...
US20110189197 Antibodies Against Protective Antigen  
The present invention relates to antibodies and related molecules that specifically bind to protective antigen of Bacillus anthracis (PA). Such antibodies have uses, for example, in the prevention...
US20060153839 Production of bispecific molecules using polyethylene glycol linkers  
The invention relates to a bispecific molecule comprising a first recognition binding moeity that binds a Cab-like receptor cross-linked using a poly-(ethylene glycol) (“PEG”) linker with one or...
US20150232517 MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO  
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use...
US20110104179 PROTEASE INHIBITORY PEPTIDES  
The present invention relates to compounds, peptides, peptidomimetics and pharmaceutical compositions that inhibit protease activity, and the use of these compounds, peptides, peptidomimetics and...
US20120027771 AFFINITY PURIFIED HUMAN POLYCLONAL ANTIBODIES AGAINST VIRAL, BACTERIAL AND/OR FUNGAL INFECTIONS AND METHODS OF MAKING AND USING THE SAME  
The present invention discloses compositions and methods for treating, preventing and/or monitoring viral, bacterial, eukaryotic protist and/or fungal infections. In some embodiments, these...
US20100260777 TREATMENT AND/OR PREVENTION OF SEPSIS USING AN ENTERAL COMPOSITION  
Treatment and/or prevention of sepsis using an enteral composition containing phospholipids, triglycerides and cholesterol or precursors thereof. With the composition of the invention the natural...
US20060121045 Antibody fragments for protection from pathogen infection and methods of use thereof  
Methods and compositions are provided for an antibody fragment or functional fragment thereof, which fragments do not contain an Fc region. The invention also describes in vitro and in vivo...
US20110206692 CONFORMERS OF BACTERIAL ADHESINS  
The invention relates to isolated or purified bacterial adhesin conformers, preferably with improved stability and/or immunogenicity. In a preferred aspect, the invention comprises an isolated...
US20080187541 HELICOBACTER PYLORI ADHESIN BINDING GROUP ANTIGEN  
A novel Helicobacter pylori blood group antigen binding (BAB) adhesin protein was isolated and purified, whereby said protein or fractions thereof bind specifically to fucosylated blood group...
US20060246079 Neutralizing human antibodies to anthrax toxin  
A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect,...
US20080031874 Treatment of endotoxemia using endotoxin neutralizing agents  
Methods and compositions for selecting a patient suffering from endotoxemia for treatment with an endotoxin neutralizing agent are disclosed comprising: (a) determining the level of endotoxin in...
US20070020281 Monoclonal antibodies specific for anthrax spores and peptides derived from the antibodies thereof  
The present invention relates to peptides that bind to the bacterial spores, such as B. anthracis, B. subtilis and B. cereus spores. The present invention also relates to method of identifying...
US20060233812 Focussed antibody technology  
The present invention concerns methods for identifying candidate sequences for antibody specific against an antigen produced by a micro-organism during an infection or against a vaccine, methods...
US20090117109 Methods For Reducing Biofilm Formation In Infectious Bacteria  
The present invention provides methods of preventing or inhibiting biofilm formation by a population of bacteria, said method comprising the administration to the population of an antibody to a...
US20130058953 CHARACTERIZATION OF THE CBIR1 ANTIGENIC RESPONSE FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE  
This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention...
US20100150943 IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA  
The invention relates to the identification of a new adhesin islands within the genomes of several Gram positive Streptococcus serotypes and isolates. Adhesin island polypeptides of the invention...
US20070178110 Surface-located campylobacter jejuni polypeptides  
The present invention relates to surface-located polypeptides of Campylobacter jejuni and their use in vaccination against Campylobacter. The invention furthermore relates to the use in...
US20090169568 Antigenic Complex for the Diagnosis and Treatment of Porphyromonas Gingivalis Infection  
The present invention provides a purified multimeric complex form P. gingivalis. The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than...
US20110027280 Methods For Inducing Autolysis In Infectious Bacteria  
The present invention relates to methods for the killing of infectious bacteria by modulating the extra-cellular concentration of bacterial cell signalling molecules. This has the effect of...
US20100239682 COLONIC DELIVERY OF ANTIMICROBIAL AGENTS  
Antimicrobial compositions for oral delivery, and administration to the colon, distal ileum, or other portion of the gastrointestinal tract other than the stomach, of bacteriophage, phage...
US20110110954 Anthrax compositions and methods of use and production  
Compositions and methods effective for eliciting an immune response for preventing or reducing infection or improving clinical outcomes caused by Bacillus anthracis are provided. The compositions...
US20100239583 ANTIBODIES AGAINST FLAGELLIN AND USES THEREOF  
The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including,...
US20100124554 REDOX-ACTIVE COMPOUNDS AND RELATED COMPOUNDS, COMPOSITIONS, METHODS AND SYSTEMS  
Compounds able to affect production and/or activity of a redox active compound, which include candidate therapeutic compounds and candidate compounds for enhancing power output of a microbial fuel...
US20050281830 Detection, prevention, and treatment systems for anthrax  
A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect,...
US20100150942 AFFINITY PURIFIED HUMAN POLYCLONAL ANTIBODIES AND METHODS OF MAKING AND USING THEM  
The present invention describes a method for treating, removing or preventing a bacterial infection, which method comprises administering to a human suffering, suspected of suffering or at risk of...
US20140037649 DIAGNOSTIC AND/OR SCREENING AGENTS AND USES THEREFOR  
Disclosed are methods and apparatus for diagnosis, detection of host response, monitoring, treatment or management of sepsis, infection-negative systemic inflammatory response syndrome (SIRS) and...
US20060222650 Broad spectrum pyrogenic antagonists and vaccines directed against pyrogenic exotoxins  
The invention relates to peptides comprising an amino acid sequence homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of...
US20100303830 PREVENTION AND TREATMENT OF OTITIS MEDIA USING IgA ENRICHED MILK  
This invention relates to a composition suitable for use in the prevention or treatment of otitis media comprising IgA derived from mature bovine milk and having specificity for at least one of...

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