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US20110177092 INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFIRI TREATMENT  
The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by...
US20110076317 Rapid establishment and/or termination of substantial steady-state drug delivery  
The present invention is directed to treatment methods for a disease or condition, in a subject in need of such treatment, that provide alternatives to treatment by injection that give, relative...
US20110014206 SCREENING METHOD FOR PREDICTING SUSCEPTIBILITY TO BREAST CANCER  
A method to aid in identifying a familial or sporadic pattern of risk in at least one individual for developing cancer of a mucosal epithelial tissue, the method comprising screening said at least...
US20140286961 Novel Methods Of Cancer Therapy Targeted Against A Cancer Stem Line  
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
US20110250201 ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP  
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of...
US20140248211 METHOD OF TREATING CANCER  
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and...
US20120141376 PROSTATE SPECIFIC TRANSCRIPTS AND THE USE THEREOF FOR PROSTATE CANCER THERAPEUTICS AND DIAGNOSTICS  
Genes that are up regulated in human prostate tumor tissues and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment,...
US20140348854 HE4 Based Therapy For Malignant Disease  
The invention provides compositions and methods for utilizing human epididymal secretory protein E4 (HE4) in the prevention and treatment of cancer and other human diseases.
US20140161813 METHODS FOR THE DIAGNOSIS, TREATMENT AND MONITORING OF CANCER  
New methods for diagnosing, treating, and monitoring cancer have been developed based on the expression level of markers, such as transcobalamin II (TCII), transcobalamin II receptor (TCIIR),...
US20110300131 DETECTION AND TREATMENT OF PANCREATIC, OVARIAN AND OTHER CANCERS  
The application provides methods of diagnosis, prognosis, prophylaxis and treatment of ovarian, pancreatic and other cancers using antibodies that specifically bind to denatured CD70.
US20140134165 Identification of Tumor-Associated Markers for Diagnosis and Therapy  
The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which...
US20130189225 METHODS OF INCREASING EFFICIENCY OF VECTOR PENETRATION OF TARGET TISSUE  
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the...
US20130028860 ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE AND/OR FEVER  
The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for...
US20110182909 Glufosfamide combination therapy  
Glufosfamide administered in combination with other chemotherapeutic agents is useful in cancer treatment.
US20120128586 METHOD FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA  
The present invention provides a method for treating a subject having chronic lymphocytic leukemia (CLL) comprising administering to the subject one or more agents that target cell surface...
US20120141475 TNF-alpha Antagonists and Methotrexate in the Treatment of TNF-Mediated Disease  
Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed is a composition comprising methotrexate and an anti-tumor necrosis factor antibody....
US20120070438 Methods for Treating Melanoma  
Methods of inhibiting melanoma tumor growth, methods of treating melanoma and metastatic melanoma, and methods of reducing the frequency of tumor initiating cells (or cancer stem cells) in...
US20120276192 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1  
RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory...
US20070009535 Treatment of cancer patients exhibiting activation of the P-glycoprotein efflux pump mechanism  
The present invention relates to a method of determining P-glycoprotein expression and/or function for a patient with solid tumors, leukemias, and other malignancies. The invention also relates to...
US20150093396 Prostate Tumor Markers And Methods Of Use Thereof  
Newly identified proteins as markers for the detection of prostate tumors, or as targets for their therapeutic treatment, affinity ligands capable of selectively interacting with said markers as...
US20110287020 RECOMBINANT VECTORS  
This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in...
US20100297118 Therapeutic Cancer Treatments  
Provided are methods for treating non-small cell lung cancer by administering a therapeutically effective amount of a hedgehog inhibitor.
US20100209944 ADAMTS-7 AS A BIOMARKER FOR CANCERS OF EPITHELIAL ORIGIN  
ADAMTS-7 expression and activity are up regulated in patients that have cancers of epithelial origin. Accordingly, the present invention is directed to methods diagnosis of cancers of epithelial...
US20060210572 Treatment of lymphatic metastatic cancerous lesions  
Methods for improving the efficacy of cancer therapy are described. In one embodiment the method involves administering the cancer therapeutic to a first cancer lesion wherein the first cancer...
US20120195830 Monoclonal Antibodies Against Claudin-18 For Treatment of Cancer  
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric...
US20110020430 Novel mRNA splice variant of the doublecortin-like kinase gene and its use in cancer diagnosis and therapy  
Methods for treating neuroblastoma in a subject are provided. The methods include administering to the subject nucleic acid that is capable of causing a significant reduction of the amount of...
US20060115424 Combination therapy of oxaliplatin and radioactively doped particles treating cancer  
A method of treating cancer in a patient comprising administering to the patient an amount of oxaliplatin in combination with radioactively doped particle, characterised in that the two therapies...
US20050158325 Immunomodulatory combinations  
The present invention provides immunomodulatory combinations that includes an IRM component and a therapeutic agent, each in an amount that, when in combination with the other, is effective for...
US20130315896 Cytotoxicity Mediation of Cells Evidencing Surface Expression of CD44  
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of primary and metastatic human tumor cells; and most particularly to the...
US20120020880 Cytotoxicity Mediation of Cells Evidencing Surface Expression of CD44  
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of primary and metastatic human tumor cells; and most particularly to the...
US20120076724 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof  
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
US20140335100 THERAPY-ENHANCING GLUCAN  
This invention provides a composition comprising an effective amount of glucan capable of enhancing efficacy of antibodies. This invention further provides the above compositions and a...
US20110195071 THERAPY-ENHANCING GLUCAN  
This invention provides a composition comprising an effective amount of glucan capable of enhancing efficacy of antibodies. This invention further provides the above compositions and a...
US20070160619 CTLA-4 Antibody Dosage Escalation Regimens  
A disease or condition, such as cancer or an infectious disease, can be treated in a patient by administering a CTLA-4 antibody in an escalating dosage regimen until a partial or complete response...
US20070009532 Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar  
The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar and a calicheamicin-antibody conjugate, such...
US20060159689 Combinations of tumor-associated antigens in diagnostics for various types of cancers  
Disclosed herein are methods for matching a cancer condition with an appropriate immunotherapeutic agent and/or regimen. Also disclosed are methods for confirming diagnosis of a particular type of...
US20070104721 Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272  
A combination of temsirolimus and herceptin in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of herceptin and HKI-272 is also provided....
US20070128201 Combined use of ecteinascidin-743 and platinum antineoplastic compounds  
ET-743 can be used to mitigate resistance to and potentiate the cytotoxic effects of a platinum coordination complex anti-neoplastic agent in a human cancer patient.
US20050031622 Treatment and diagnosis of cancer using inositolphosphoglycans antagonists  
Inositolphosphoglycans (IPGs), and in particular A-type substances comprising myo-inositol, are tumour autocrine factors (TAFs), that is factors which cause tumour cell proliferation. The use of...
US20070071762 COMPREHENSIVE DIAGNOSTIC TESTING PROCEDURES FOR PERSONALIZED ANTICANCER CHEMOTHERAPY (PAC)  
The present invention provides methods of assessing and selecting treatment modalities for cancer.
US20080050730 Early Detection of Hemangiosarcoma and Angiosarcoma  
A variety of methods, compositions and kits are provided for the early detection, diagnosis and treatment of hemangiosarcoma in dogs and angiosarcomas in humans.
US20090060913 COMBINATION THERAPY WITH TYPE I AND TYPE II ANTI-CD20 ANTIBODIES  
The present invention is directed to a combination therapy involving a type I anti-CD20 antibody and a type II anti-CD20 antibody for the treatment of a patient suffering from cancer, particularly...
US20110171229 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20060110396 Use of ligands of the antigen CDw52 for the treatment of diseases that are related to degenerated macrophages  
The present invention relates to the use of a ligand of CDw52 for the preparation of a medicament for the treatment of diseases that are related to CDw52 expressing degenerated macrophages. In...
US20110256147 DIAGNOSTIC AND TREATMENT METHODS FOR CANCER BASED ON IMMUNE INHIBITORS  
Methods of diagnosis and treatment of malignant tumors, in particular ovarian tumors, using GD3 and GD3 inhibitors. Also provided are methods of modulating the immune system of a mammal by the...
US20110250166 COMBINATION OF ROCAGLAMIDE AND APOPTOSIS INDUCING SUBSTANCES FOR THE TREATMENT OF CANCER  
The present invention relates to a combined preparation comprising at least one rocaglamide derivative and at least one apoptosis inducing agent, preferably from the group of substances comprising...
US20110229552 NOVEL mRNA SPLICE VARIANT OF THE DOUBLECORTIN-LIKE KINASE GENE AND ITS USE IN DIAGNOSIS AND THERAPY OF CANCERS OF NEUROECTODERMAL ORIGIN  
The present invention relates to novel nucleic acid and protein molecules and their use in cancer therapy and diagnosis.
US20050118658 Use of ERRalpha phosphorylation status as a breast cancer biomarker  
The inventors discovered that the ErbB2 signal transduction pathway can activate ERRĪ± by inducing its phosphorylation. Based on this discovery, the present invention provides methods for...
US20070003559 METHODS OF DETERMINING PHARMACOKINETICS OF TARGETED THERAPIES  
Methods for determining pharmacokinetics of targeted therapies.
US20070032457 Combination therapy for cancer treatment  
The present invention provides methods of treating cancer, the methods generally involving combination therapy. The methods are useful as primary cancer therapy, or as adjuvant therapy. The...

Matches 1 - 50 out of 428 1 2 3 4 5 6 7 8 9 >