Matches 1 - 50 out of 278 1 2 3 4 5 6 >


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US20140314787 Treatment for neurodegenerative diseases  
The present application provides a method for treating a neurodegenerative disease in a subject characterised in that the endoplasmic reticulum protein retrotranslocation machinery and/or VCP is...
US20130095105 Treatment of Ocular Disease  
Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular...
US20140227284 SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER  
Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the...
US20130004504 METHOD OF MODULATING PHENYLALANINE HYDROXYLASE STRUCTURE AND FUNCTION  
A method of affecting a multimeric protein comprising an equilibrium of assembly states, each assembly having a plurality of units, wherein each of the units comprises a first complementary...
US20120258146 Method of treating organic diseases of nervous system, pschoorganic syndrome and encephalopathy  
The present invention relates to a method of treating organic disease of the nervous system, psychoorganic syndrome or encephalopathy of various genesis by administration of activated-potentiated...
US20130095065 Methods for Treating Vascular Leak Syndrome and Cancer  
Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, sepsis, cancer...
US20100297070 COMPOSITIONS AND METHODS FOR AMELIORATING CNS INFLAMMATION, PSYCHOSIS, DELIRIUM, PTSD or PTSS  
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated...
US20140030270 METHODS OF TREATING OR PREVENTING CHOLESTEROL RELATED DISORDERS  
The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein...
US20130280269 Manipulation of HSP70 and IRE1Alpha Protein Interactions  
The present invention relates to methods that manipulate the level of interaction between the proteins Hsp70 and IRE1α. In particular, the invention relates to methods of manipulating this...
US20150132317 METHODS AND COMPOSITIONS FOR TREATING NEUROBLASTOMA  
Methods and compositions for treating neuroblastoma are disclosed.
US20110150772 MODULATORS OF CARNITINE OCTANOYLTRANSFERASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with...
US20140294854 TARGET DIRECTED TO ADIPOCYTES, METHODS AND ASSAYS FOR TREATMENT OF OBESITY  
The present invention provides compositions and methods for treating obesity in a subject by administering an inhibitor of UBE2L6 or an activator of adipocyte triglyceride lipase to the subject.
US20110262450 MODULATORS OF MONOGLYCERIDE LIPASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with...
US20110262451 MODULATORS OF ISOVALERYL-COENZYME A DEHYDROGENASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with...
US20110150773 MODULATORS OF ACETYL-COENZYME A ACYLTRANSFERASE 1 OR 2 IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA  
An in vitro method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes...
US20110059100 C/CLP Antagonists And Methods Of Use Thereof  
The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or...
US20110262361 EFFECTIVE NEW DRUG TARGET FOR THE TREATMENT OF TUBERCULOSIS  
The present invention allows a screening method for identifying novel drugs for the treatment of tuberculosis as well as a diagnostic method for identifying clinical strains that are resistant to...
US20130095113 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS  
The present disclosure provides methods for treating neurological disorders, generally involving modulating protein kinase D1 (PKD1) activity levels in a neuron or glial cell in an individual in...
US20110104175 METHODS OF TREATMENT FOR PULMONARY FIBROSIS  
The invention relates to compositions and methods for treating fibrosing lung diseases, reducing pulmonary cytokine production in animals, treating bleomycin induced lung disease and treating...
US20110305701 Methods and Compositions to Treat and Detect Misfolded-SOD1 Mediated Diseases  
The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method...
US20150175712 ANTAGONIST TO AN ENZYME AND/OR A METABOLITE OF THE KYNURENINE PATHWAY  
The present invention relates to a modulator of an enzyme and/or a metabolite of the kynurenine pathway (FIG. 18).
US20050074455 Treatment of neovascular opthalmic disease  
Inhibitors of integrin-linked kinase (ILK) are used in the treatment of various eye diseases with underlining pathology of neovascularization of cornea, iris, retina or choroid.
US20120240245 Methods and compositions for detecting and treating retinal diseases  
The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD...
US20130058982 Method of treating Alzheimer's disease  
The present invention relates to a method of treating Alzheimer's disease by administration of activated-potentiated form of antibodies to brain-specific protein S-100 and activated-potentiated...
US20140314746 METHODS FOR TREATING OR PREVENTING FIBROSIS IN SUBJECTS AFFLICTED WITH SCLERODERMA  
The invention includes novel methods of treating or preventing fibrosis in a subject afflicted with scleroderma, comprising administering to the subject a therapeutically effective amount of an...
US20150064134 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS, OR PROCESSES CHARACTERIZED BY ABERRANT FIBROBLAST PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITION  
The described invention provides compositions and methods for treating asthma, a disease, condition or pathologic process whose progression is characterized by one or more of aberrant fibroblast...
US20150239985 Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation  
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject...
US20110311549 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION  
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject...
US20140178399 ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASE AND THERAPEUTICS  
Certain embodiments are directed to compositions and methods of inhibiting pathogenic bacterial infection involving ADAMIO comprising administering an effective amount of a metalloprotease...
US20070026029 Apheresis device  
The invention relates to an apharesis device for use in the treatment of Alzheimer patients. Said device comprises a solid support with which a flow of blood or plasma can be contacted.
US20120321672 Method of treating attention deficit hyperactivity disorder  
The present invention relates to a method of treating attention deficit hyperactivity disorder (ADHD) and attention deficit disorder (ADD) by administration of activated-potentiate form of...
US20110223177 TREATMENT OF FIBROTIC EYE DISORDERS  
Inhibitors of myosin activity are used to treat or prevent a fibrotic disorder of the eye, for example posterior capsule opacification (PCO).
US20140093494 ALPHA SYNUCLEIN TOXICITY  
It is demonstrated that alpha synculein toxicity such as α-synuclein mediated cell death, and alpha synuclein induced reactive oxygen species (ROS) in a cell requires proapoptotic endonuclease G...
US20050090466 Inhibitors of PACE4 for the treatment of arthritis  
Disclosed are methods and compositions for the treatment of arthritis using inhibitors of PACE4.
US20130022611 METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR  
The invention provides methods and compositions for modulating hepsin activity and the uPA/plasmin pathway, in particular by regulating pro-uPA activation by hepsin.
US20120213794 AX213 AND AX132 PSCK9 ANTAGONISTS AND VARIANTS  
Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present...
US20120219558 ANTAGONISTS OF PCSK9  
Antagonists of human proprotein convertase subtilisin-kexin type 9 (PCSK9) are disclosed. Said antagonists are effective in the inhibition of PCSK9 function and thereby provide compositions of...
US20150210774 Compositions and Methods for Detecting, Treating and Preventing Diseases and Disorders  
The invention described herein relates to the discovery that renalase, and fragments thereof, are useful for the treatment or prevention of cardiac and renal diseases or disorders. Thus, the...
US20060240422 Caspase 10 as target for monitoring and treatment of diseases  
The present invention relates to a method of monitoring and/or modulating disease-associated activatory procceses which are mediated by caspase-10 or caspase-10 isoforms.
US20060177448 Inhibiting HER2 shedding with matrix metalloprotease antagonists  
The present application describes using antagonists of matrix metalloproteases (MMPs), especially of MMP-15, for inhibiting HER2 shedding.
US20150232572 COMBINATION TREATMENT OF CANCER  
The present invention provides MT4-MMP inhibitor and EGFR inhibitor for use in the treatment of cancer, wherein said MT4-MMP inhibitor and EGFR inhibitor are different from each other. MT4-MMP...
US20130110249 ANTI-GLUCOSAMINIDASE PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS AUREUS INFECTIONS  
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are...
US20060002936 Method of modulating platelet activation  
The present invention relates to a method of treating a disease or condition mediated by platelet activation comprising supplying a therapeutically effective amount of an ERP5 inhibitor to a...
US20140099323 METHODS FOR TREATMENT OF INFLAMMATORY DISEASES  
It provides methods and pharmaceutical compositions comprising antagonists to the protein Bile Salt-Stimulated Lipase (BSSL) for the prevention, prophylaxis and treatment of inflammatory diseases,...
US20120093829 NEW METHODS FOR TREATMENT OF INFLAMMATORY DISEASES  
It provides methods and pharmaceutical compositions comprising antagonists to the protein Bile Salt-Stimulated Lipase (BSSL) for the prevention, prophylaxis and treatment of inflammatory diseases,...
US20070280947 Tie Receptor and Tie Ligand Materials and Methods for Modulating Female Fertility  
The present invention provides materials and methods involving Tie receptors and Angiopoietin ligands for modulating female fertility in mammals, including humans. Materials and methods for...
US20120258115 THERAPEUTIC FORMULATIONS CONTAINING VENOM OR VENOM ANTI-SERUM EITHER ALONE OR IN COMBINATION FOR THE THERAPEUTIC PROPHYLAXIS AND THERAPY OF NEOPLASMS  
A method of treating a mammal prophylactically to prevent neoplastic development comprises administering to the mammal a therapeutic vaccine comprising venom and at least one adjuvant. The method...
US20140348850 METHOD FOR REDUCING BLOOD PRESSURE USING INHIBITORS OF PLASMA KALLIKREIN  
The present invention relates to methods of reducing blood pressure in a subject by administering a plasma kallikrein inhibitor.
US20110318359 METHOD FOR REDUCING BLOOD PRESSURE USING INHIBITORS OF PLASMA KALLIKREIN  
The present invention relates to methods of reducing blood pressure in a subject by administering a plasma kallikrein inhibitor.
US20070160585 Remedy for prion disease and method of producing the same  
It is intended to provide a drug which is efficacious in treating a prion disease and has a high safety. A remedy for a prion disease which contains a mesenchymal stem cell as the active...

Matches 1 - 50 out of 278 1 2 3 4 5 6 >