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US20130302320 |
Use of Semaphorin-4D Binding Molecules to Promote Neurogenesis Following Stroke
Provided herein are methods for promoting neurogenesis in neural tissue of a patient exhibiting at least one symptom of a central nervous system disorder, the method comprising administering to a... |
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US20110158993 |
Train-R: A Cysteine Rich Member of the TNF-Receptor Family
Novel receptor in the TNF family: TRAIN-receptor. |
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US20120201821 |
Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma
The present invention provides methods and means to reduce gastrointestinal inflammation. In particular, the invention provides methods and means to treat inflammatory bowel disease (IBD) and... |
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US20140341926 |
METHOD FOR EGFR DIRECTED COMBINATION TREATMENT OF CANCER
The present invention relates to a method of treating patients suffering from cancers driven by deregulated Human Epidermal Growth Factor Receptor (HER/Human EGFR), wherein an irreversible... |
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US20120141471 |
Methods of Inhibiting Metastasis from Cancer
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or... |
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US20130115206 |
Compositions and Methods for Treating and Diagnosing Cancer
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in... |
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US20130216540 |
MODULATION OF THE INNATE IMMUNE SYSTEM THROUGH THE TREM-LIKE TRANSCRIPT 2 PROTEIN
TREM-like transcript 2 (TLT2), is expressed on neutrophils, macrophages, and B lymphocytes. Expression of TLT2 is up-regulated on neutrophils and macrophages in response to inflammatory stimuli in... |
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US20130224214 |
Compositions and Methods for Therapy and Diagnosis of Cancer and Cancer Metastasis
The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer.... |
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US20140127134 |
TREATMENT AND PREVENTION OF CANCER WITH HMGB1 ANTAGONISTS
Embodiments provided herein relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma... |
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US20150212088 |
COMPOSITIONS AND METHODS FOR DETECTING AND TREATING COLORECTAL CANCER
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the interaction between a subject's immune system and cancer stem cells. In... |
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US20150044135 |
DUAL FUNCTION MARKERS FOR DIAGNOSTICS AND THERAPEUTICS FOR UPPER GASTROINTESTINAL TRACT PRECANCER
The invention described herein relates to the detection, diagnosis, and treatment of intestinal metaplasias that develop to esophageal, gastric, and pancreatic adenocarcinoma. The stem cells and... |
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US20140328904 |
GLA MONOTHERAPY FOR USE IN CANCER TREATMENT
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen. |
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US20140314834 |
GLA MONOTHERAPY FOR USE IN CANCER TREATMENT
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen. |
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US20110142756 |
Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called... |
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US20110027173 |
EPHRIN TYPE-A RECEPTOR 10 PROTEIN
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,... |
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US20110064737 |
ErbB ANTAGONISTS FOR PAIN THERAPY
The present application describes the use of ErbB antagonist, especially ErbB2 antibodies such as rhuMAb 2C4, for treating pain. |
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US20130108643 |
METHOD TO TREAT AUTOIMMUNE DEMYELINATING DISEASES AND OTHER AUTOIMMUNE OR INFLAMMATORY DISEASES
The invention relates to methods of preventing or inhibiting the onset and/or treating autoimmune demyelinating neuropathy and other autoimmune or inflammatory diseases involving macrophage... |
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US20140248211 |
METHOD OF TREATING CANCER
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and... |
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US20120029473 |
USE OF 5C8 MAB AND DIRECT INDUCTION OF REGULATORY CD8+ T CELLS TO ESTABLISH PERMANENT AND SPECIFIC TRANSPLANTATION TOLERANCE
A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term... |
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US20100316640 |
POLYSACCHARIDE COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT AND PREVENTION OF DISORDERS ASSOCIATED WITH PROGENITOR CELL MOBILIZATION
Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided. |
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US20130195880 |
Identification of Polymorphisms and Their Use as Markers for Disease Susceptibility, Diagnosis and Treatment Optimization
Provided are methods and kits to determine whether a subject is predisposed to developing a disease or condition associated with structural polymorphisms in genes CNTNAP2 and CNTNAP4, along with... |
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US20130084281 |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS
Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject. |
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US20110091452 |
4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g.... |
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US20110104256 |
METHODS FOR TREATING OR PREVENTING COLORECTAL CANCER
The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and... |
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US20120128673 |
MODULATION OF PILR RECEPTORS TO TREAT MICROBIAL INFECTIONS
The present invention provides methods of using agonists and antagonists of PILRα and PILRβ, respectively, to treat S. aureus infection, in particular, S. aureus infections of the lungs. Also... |
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US20150132315 |
METHODS TO IMPAIR HEMATOLOGIC CANCER PROGENITOR CELLS AND COMPOUNDS RELATED THERETO
Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous... |
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US20130164215 |
COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the... |
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US20150023965 |
METHODS OF TREATING UROTHELIAL CARCINOMA
Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed. |
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US20140050730 |
METHODS FOR DIAGNOSING AND TREATING NEUROENDOCRINE CANCER
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2.... |
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US20060002924 |
Conjugate of notch signalling pathway modulators and their use in medical treatment
Conjugates comprising a plurality of modulators of the Notch signalling pathway chemically bound to a support structure are described. The conjugates are useful for modulation of the Notch... |
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US20130295108 |
METHOD FOR TREATING SYNOVIAL SARCOMA
Methods of detecting synovial sarcoma using differentially expressed genes are disclosed. Also disclosed are methods of identifying agents for treating synovial sarcoma. Further, a method for... |
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US20150259435 |
HER2- AND VEGF-A-BINDING PROTEINS WITH ENHANCED STABILITY
The invention provides HER2-binding proteins and VEGF-A-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided. |
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US20090155259 |
EXTENDING TIME TO DISEASE PROGRESSION OR SURVIVAL IN CANCER PATIENTS
The present application describes extending time to disease progression or survival in a cancer patient, where the patient's cancer displays HER activation, by treating the patient with a HER... |
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US20110150894 |
METHODS OF MODULATING ANGIOGENESIS VIA TRPV4
The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating... |
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US20140322130 |
SPECIFIC BINDING PROTEINS AND USES THEREOF
The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express... |
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US20120308577 |
DNA VACCINES AND METHODS FOR THE PREVENTION OF TRANSPLANTATION REJECTION
Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX... |
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US20150197574 |
USE OF TRANSFERRIN RECEPTOR ANTAGONIST FOR THE TREATMENT OF THALASSEMIA
The present disclosure relates to antagonists of transferrin receptor and compositions and methods of use of said antagonists for treating pathological disorders such as thalassemia disorders |
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US20140370004 |
METHOD OF BOOSTING THE IMMUNE RESPONSE IN NEONATES
In an aspect, a method of augmenting an immune response in a subject in need thereof, comprising identifying the subject, and treating the subject to inhibit the immune suppressive effect of CD71+... |
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US20120003219 |
Compositions and Methods to Treat Bone Related Disorders
The present invention relates to the use of modulators of the sclerostin:sclerostin-binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders,... |
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US20140255388 |
TOLL LIKE RECEPTOR 3 ANTAGONISTS, METHODS AND USES
Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments, and methods of making and using the foregoing are disclosed. |
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US20130280263 |
Toll-Like Receptor 3 Antagonists
Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed. |
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US20140120082 |
MODULATION OF NKG2D
The present invention relates to methods and compositions for treating and/or preventing autoimmune and/or inflammatory disease. In particular, the present invention provides therapeutics for... |
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US20150079104 |
Methods For Inhibiting The Binding Of Endosialin To Ligands
The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression,... |
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US20110280885 |
CANCER IMMUNOTHERAPY
A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the... |
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US20100297121 |
Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal Cell Survival Via Administration of LINGO-1 Antagonists and TrkB Agonists
This invention relates to methods for promoting neuronal survival and regeneration using LINGO-1 antagonists and TrkB agonists. Additionally, the invention relates to methods for treating pressure... |
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US20110044991 |
METHODS AND COMPOSITIONS FOR TREATING LYMPHOMA AND MYELOMA
This invention relates to the use of antagonists of the hedgehog signaling pathway to induce apoptosis of lymphoma and myeloma cells and to treat subjects suffering from various forms of lymphoma... |
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US20130343996 |
GRAPHITE-COATED MAGNETIC NANOPARTICLES
The present invention relates to graphite-coated magnetic nanoparticles, methods for the synthesis of graphite-coated magnetic nanoparticles, and methods of using graphite-coated magnetic... |
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US20110214194 |
COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY
Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for... |
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US20130011407 |
PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF OSTEOARTHRITIS, AND METHOD OF PRODUCTION THEREFOR
Pharmaceutical compositions for treating or preventing diseases classified as any of grade 1 to 3 according to the ICRS classification of osteoarthritis, classified as any of grade 1 to 3... |
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US20100061994 |
MEDICAL USES OF 39-DESMETHOXYRAPAMYCIN AND ANALOGUES THEREOF
The present invention relates to medical uses of 39-desmethoxyrapamycin analogues. |