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US20160022582 HIGHLY CONCENTRATED DRUG PARTICLES, FORMULATIONS, SUSPENSIONS AND USES THEREOF  
Highly concentrated drug particle formulations are described, wherein the drug comprises between about 25 wt % and 80 wt % of the particle formulation. The particle formulations of the present...
US20100092566 Highly concentrated drug particles, formulations, suspensions and uses thereof  
Highly concentrated drug particle formulations are described, wherein the drug comprises between about 25 wt % and 80 wt % of the particle formulation. The particle formulations of the present...
US20050048049 Prevention and treatment of amyloidogenic disease  
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid...
US20150165059 SOLUBLE GLYCOSAMINOGLYCANASES AND METHODS OF PREPARING AND USING SOLUBLE GLYCOSAMINOGLYCANASES  
The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules...
US20150132363 SOLID DRESSING FOR TREATING WOUNDED TISSUE  
Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator,...
US20150118284 SOLID DRESSING FOR TREATING WOUNDED TISSUE  
Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and thrombin,...
US20140205598 Methods for Treating Disseminated Intravascular Coagulation by Inhibiting MASP-2 Dependent Complement Activation  
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating...
US20130064825 METHODS OF TREATING OR PREVENTING CHOLESTEROL RELATED DISORDERS  
The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein...
US20100172862 STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME  
The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine,...
US20100061985 ANTAGONISTS OF TWEAK AND OF TWEAK RECEPTOR AND THEIR USE TO TREAT IMMUNOLOGICAL DISORDERS  
The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.
US20100040627 BAFF RECEPTOR (BCMA), AN IMMUNOREGULATORY AGENT  
A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
US20100003261 AGONIST ANTI-TRK-C MONOCLONAL ANTIBODIES  
The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such...
US20090297511 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE  
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid...
US20090142263 Cytotoxicity mediation of cells evidencing surface expression of TROP-2  
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell...
US20090087440 Methods for Treating Cancer  
Dendritic cells (DC) play a critical role in antigen-specific immune responses. Materials and Methods are provided for treating disease states, including cancer, by activating dendritic cells from...
US20090081213 METHODS AND COMPOSITIONS FOR USE IN TREATMENT OF PATIENTS WITH AUTOANTIBODY POSITIVE DISEASE  
The present invention relates to methods and compositions for use in treatment of patients with autoantibody positive disease. In a specific embodiment, the present invention relates to a method...
US20080193546 SOLID DOSE DELIVERY VEHICLE AND METHODS OF MAKING SAME  
The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and...
US20080181890 Optimized Fc Variants and Methods for Their Generation  
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
US20080081040 Methods for treating bone cancer pain by administering a nerve growth factor antagonist  
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth...
US20080057069 Method of increasing trafficking of endothelial progenitor cells to ischemia-damaged tissue  
This invention provides a method of increasing trafficking of endothelial progenitor cells to ischemia-damaged tissue in a subject comprising administering to the subject an agent that inhibits...
US20080050385 TUMOR THERAPY WITH AN ANTI-VEGF ANTIBODY  
The present invention provides a method of treating a patient suffering from relapsed HER2 positive cancer with an anti-VEGF antibody during or after treatment with an anti-HER2 antibody. The...
US20080019970 METHODS FOR PREVENTING, POSTPONING OR IMPROVING THE OUTCOME OF SPINAL DEVICE AND FUSION PROCEDURES  
Methods for identifying subjects who could benefit therapeutically from administration of a high specificity cytokine inhibitor are provided. Subjects that are identified include those that are...
US20080019969 Methods for Preventing, Postponing or Improving the Outcome of Invasive Spinal Procedures  
Methods for identifying subjects who could benefit therapeutically from administration of a targeted anti-inflammatory therapy (TAT) are provided. Subjects that are identified include those that...
US20070060528 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS  
Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4- dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are...
US20060263355 Treatment of bone disorders  
Methods of treatment of various bone indications, such as osteoporosis, in a mammal are provided wherein an effective amount of an antagonist that binds to a B-cell surface marker, such as a CD20...
US20060257396 Abeta antibodies for use in improving cognition  
The invention provides improved agents and methods for treatment of diseases associated with beta amyloid (Aβ). Preferred agents include antibodies, e.g., humanized antibodies specific for Aβ.
US20060233791 Anti-CD19 antibodies and uses in oncology  
The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies, using...
US20050276803 Method for augmenting B cell depletion  
The present invention provides methods of augmenting B cell depletion by promoting intravascular access of B cell subsets sequestered in lymphoid tissues rendering the B cells sensitive to killing...
US20050191292 Prevention and treatment of amyloidogenic disease  
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid...
US20050142132 Prevention and treatment of amyloidogenic disease  
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce...
US20050074454 Methods of treating carcinoma using anti-TNF antibodies and peptides  
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies...
US20050025764 CD20 binding molecules  
The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a...
US20160176986 HIGH-CONCENTRATION MONOCLONAL ANTIBODY FORMULATIONS  
The present application discloses high-concentration monoclonal antibody formulations suitable for subcutaneous administration, e.g. via a pre-filled syringe. In particular, it discloses a...
US20160137750 METHOD OF TREATING A PATHOLOGICAL SYNDROME  
A method of treating disorder or condition that relates to intracellular signal transmission of a neurotransmitter, comprising administration of an homeopathically potentized form of antibodies to...
US20150037347 METHOD OF TREATING A PATHOLOGICAL SYNDROME AND A PHARMACEUTICAL AGENT  
A method of treating a pathological syndrome includes administration of an activated form of ultra-low doses of antibodies to an antigen, wherein said activated form is obtained by repeated...
US20130309226 HIGH-CONCENTRATION MONOCLONAL ANTIBODY FORMULATIONS  
The present application discloses high-concentration monoclonal antibody formulations suitable for subcutaneous administration, e.g. via a pre-filled syringe. In particular, it discloses a...
US20130195867 RNA-CODED ANTIBODY  
The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of a pharmaceutical composition, in...
US20130164284 COMPOSITIONS AND METHODS TO TREAT BONE RELATED DISORDERS  
The present invention relates to the use of modulators of the sclerostin: sclerostin-binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders,...
US20120321692 Methods and Dressings for Sealing Internal Injuries  
Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal...
US20110223208 Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations  
The present invention relates to non-aqueous high concentration reduced viscosity suspension formulations and methods of making and using them.
US20110044988 METHODS OF TREATMENT USING ANTI-MIF ANTIBODIES  
Disclosed herein, in certain embodiments, is a method for treating an inflammatory disorder. In some embodiments, the method comprises administering an active agent that inhibits (i) MIF binding...
US20110038861 Methods of Treating Alzheimer's Disease Using Antibodies Directed Against Amyloid Beta Peptide and Compositions Thereof  
Monoclonal antibodies directed against amyloid beta peptide and methods of using same for treatment and prevention of Alzheimer's disease and Down's syndrome are described.
US20110027273 IMMUNOTHERAPY OF AUTOIMMUNE DISORDERS  
Compositions and methods for treating autoimmune diseases are described. In particular, the use of B cell depleting agents and cytotoxic drug/B cell depleting agent conjugates with a drug loading...
US20100221250 METHODS OF TREATING BRAIN TUMORS WITH ANTIBODIES  
The application is directed toward a method of treating a brain tumor in a patient comprising systemically administering a monoclonal antibody.
US20100183612 METHODS OF TREATMENT USING CTLA4 MUTANT MOLECULES  
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4...
US20090269302 HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING  
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize...
US20080260734 COMPOSITIONS AND METHODS FOR CHARACTERIZING, REGULATING, DIAGNOSING, AND TREATING CANCER  
The present invention relates to compositions and methods for characterizing, regulating, diagnosing, and treating cancer. For example, the present invention provides compositions and methods for...
US20080247955 Inflammation treatment, detection and monitoring via TREM-1  
The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP...
US20080181893 Therapeutic methods for treating vascular eye disorders with DII4 antagonists  
A therapeutic method for treating ischemic or vascular disorders by administering an agent capable of inhibiting human delta-like ligand 4 (Dll4) activity to a subject in need thereof. In one...
US20080118510 VEGF-RELATED PROTEIN  
A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third...