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US20120201821 |
Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma
The present invention provides methods and means to reduce gastrointestinal inflammation. In particular, the invention provides methods and means to treat inflammatory bowel disease (IBD) and... |
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US20140178389 |
IL-1 BINDING PROTEINS
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of... |
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US20150044217 |
METHODS FOR THE TREATMENT OF HER2 AMPLIFIED CANCER
Described herein are methods and compositions for treating HER2-amplified cancer. The methods include administering to an individual in need thereof ibrutinib. |
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US20150209426 |
TREATMENT OF CANCER
A method for treating breast cancer with an insulin-like growth factor (IGF) receptor antagonist in combination with exemestane and everolimus. |
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US20140356281 |
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. |
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US20140271458 |
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. |
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US20130236458 |
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-13 AND/OR IL-17
Engineered multivalent and multispecific binding proteins that bind IL-13 and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. |
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US20110189184 |
MODULATION OF NEURAL STEM CELLS AND NEURAL PROGENITOR CELLS
The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes... |
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US20150056205 |
STEROID SPARING AGENTS AND METHODS OF USING SAME
This invention relates generally to methods of treating inflammatory bowel diseases (IBD), asthma, Crohn's Disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), graft versus host... |
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US20140219913 |
Dual Specific Binding Proteins Having a Receptor Sequence
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. |
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US20140065147 |
Use of Cytokine Expression to Predict Skin Inflammation; Methods of Treatment
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19,... |
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US20120276105 |
USE OF CYTOKINE EXPRESSION TO PREDICT SKIN INFLAMMATION; METHODS OF TREATMENT
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19,... |
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US20130195870 |
ERBB3 Mutations In Cancer
The present invention concerns somatic ErbB3 mutations in cancer including methods of identifying, diagnosing, and prognosing ErbB3 cancers, as well as methods of treating cancer, including... |
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US20120076787 |
COMBINATION OF A TNF-ALPHA ANTAGONIST AND A VEGF ANTAGONIST FOR USE IN THE TREATMENT OR PREVENTION OF DISEASES OF THE EYE
The invention relates to combinations of TNFα antagonists with VEGF antagonists for use in treating diseases of the eye, and provides antigen-binding proteins which bind to TNFα or a TNFα receptor... |
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US20130230524 |
Protein Involved in Ovarian Cancer
The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including... |
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US20110059088 |
Protein involved in ovarian cancer
The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including... |
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US20140294826 |
Methods and compositions with a recombinant neutralizing binding protein for treating toxin exposure
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant... |
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US20120183543 |
DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention... |
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US20120052070 |
COMPOSITIONS AND METHODS OF USE FOR BINDING MOLECULES TO DICKKOPF-1 OR DICKKOPF-4 OR BOTH
Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf-1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted... |
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US20100297127 |
USE OF IL-27 ANTAGONISTS TO TREAT LUPUS
This invention relates to methods of treating the autoimmune disorder lupus with IL-27 antagonists, as well as articles of manufacture comprising IL-27 antagonists. The invention also relates to... |
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US20140161804 |
BISPECIFIC IMMUNOBINDERS DIRECTED AGAINST TNF AND IL-17
Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided. |
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US20140079705 |
BISPECIFIC IMMUNOBINDERS DIRECTED AGAINST TNF AND IL-17
Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided. |
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US20130164291 |
METHOD OF TREATING INFLAMMATORY BOWEL DISEASE
A method for treating or preventing an inflammatory bowel disease (IBD) in a subject, the method comprising administering to the subject a compound that inhibits granulocyte-macrophage colony... |
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US20140242081 |
DOSING REGIMENS FOR TREATMENT OF CEA-EXPRESSING CANCERS
The present disclosure provides compositions and methods for treating CEA-expressing cancers. Methods for dosing a patient with an antibody that binds to CEA and human CD3 are also provided. |
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US20130129734 |
COMPOSITION AND METHODS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LEUKEMIA
The present disclosure relates generally to compositions and methods for the diagnosis, prognosis and treatment of leukemia, in particular leukemia in which leukemic cells, or neoplastic... |
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US20110027173 |
EPHRIN TYPE-A RECEPTOR 10 PROTEIN
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,... |
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US20150050238 |
TREATMENT OF OSTEOARTHRITIS AND PAIN
The present invention relates to the treatment of osteoarthritis and pain using IL-1α and IL-1β binding proteins, including anti-IL-1α and anti-IL-1β antibodies and engineered multivalent and... |
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US20120251439 |
Antigens Associated with Inflammatory Bowel Disease Including Ulcerative Colitis
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of inflammatory bowel disease such as ulcerative colitis... |
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US20120201822 |
TUMOR TREATMENT
The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of... |
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US20140271457 |
Dual Specific Binding Proteins Directed Against TNF
Engineered multivalent and multispecific binding proteins that bind TNFα and IL-13, TNFα and PGE2, or TNFα and NGF are provided, along with methods of making and uses in the prevention, diagnosis,... |
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US20140112926 |
Fc VARIANTS
Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a... |
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US20120058048 |
DIRECTED RADIOTHERAPY
The present invention relates enhanced targeting of drug delivery vehicles to vascular endothelial cells |
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US20130084293 |
HISTAMINE-RELEASING FACTOR (HRF), HRF-RECEPTOR AND METHODS OF MODULATING INFLAMMATION
Methods of treating a food allergy, allergic reactions, hypersensitivity, inflammatory responses, inflammation are provided. In one method, histamine releasing factor (HRF)/translationally... |
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US20130323246 |
USE OF MDL-1 ANTAGONISTS TO TREAT SPONDYLARTHROPATHY
The invention provides methods for treating spondylarthropathy with antagonists of MDL-1 alone or in combination with IL-23 antagonists. |
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US20150210770 |
THERAPEUTIC AND DIAGNOSTIC TARGET
The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of cancer, such as bladder cancer, esophagus cancer, head and neck cancer, lung cancer,... |
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US20150203592 |
COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS
The present invention relates to the treatment of osteoarthritis in a human subject using anti-IL-1α and anti-IL-1β DVD-Ig proteins. In various embodiments, the osteoarthritis includes knee... |
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US20150037278 |
INITIAL RELATIVE LYMPHOCYTE COUNT AS PREDICTIVE BIOMARKER
The invention relates to a method for predicting an improved therapeutic benefit for an individual with a tumor load before initiating an immune therapy which is capable of activating immune cells... |
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US20130177498 |
METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY AND DETECTION OF INFLAMMATORY AND IMMUNE-DYSREGULATORY DISEASE, INFECTIOUS DISEASE, PATHOLOGIC ANGIOGENESIS AND CANCER
Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The... |
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US20130108639 |
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER
The invention provides a fusion protein comprising (a) a first protein comprising a polypeptide which specifically binds to Annexin A1 and (b) a second protein comprising a polypeptide which... |
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US20110177075 |
TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods... |
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US20110104256 |
METHODS FOR TREATING OR PREVENTING COLORECTAL CANCER
The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and... |
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US20150125397 |
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IMMUNE CELL RECEPTORS AND AUTOANTIGENS
Engineered multivalent and multispecific binding proteins that bind immune cell receptors and/or autoantigens are provided, along with methods of making and uses in the prevention, diagnosis,... |
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US20110097327 |
PRODUCT AND METHOD FOR TREATMENT OF CONDITIONS ASSOCIATED WITH RECEPTOR-DESENSITIZATION
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell... |
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US20130295098 |
MULTISPECIFIC EPITOPE BINDING PROTEINS AND USES THEREOF
The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases. |
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US20150064186 |
METHODS OF TREATING LIVER CONDITIONS USING NOTCH2 ANTAGONISTS
Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include,... |
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US20140154252 |
SINGLE-CHAIN MULTIVALENT BINDING PROTEINS WITH EFFECTOR FUNCTION
Variations on the structural themes for multivalent binding molecules with effector function, or scorpions, will be apparent to those of skill in the art upon review of the present disclosure, and... |
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US20110059089 |
Protein Markers for Cardiovascular Events
The present invention relates to a method for predicting the risk of a subject developing a cardiovascular event comprising detecting at least one biomarker in (a sample of) the cardiovascular... |
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US20140193333 |
THERAPEUTIC AND DIAGNOSTIC TARGET
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer,... |
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US20130164215 |
COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the... |
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US20140302036 |
PROTEINS SPECIFIC FOR BAFF AND B7RP1
Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins. |