Match Document Document Title
US20120201821 Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma  
The present invention provides methods and means to reduce gastrointestinal inflammation. In particular, the invention provides methods and means to treat inflammatory bowel disease (IBD) and...
US20140178389 IL-1 BINDING PROTEINS  
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of...
US20150044217 METHODS FOR THE TREATMENT OF HER2 AMPLIFIED CANCER  
Described herein are methods and compositions for treating HER2-amplified cancer. The methods include administering to an individual in need thereof ibrutinib.
US20150209426 TREATMENT OF CANCER  
A method for treating breast cancer with an insulin-like growth factor (IGF) receptor antagonist in combination with exemestane and everolimus.
US20140356281 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20140271458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20130236458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-13 AND/OR IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-13 and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20110189184 MODULATION OF NEURAL STEM CELLS AND NEURAL PROGENITOR CELLS  
The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes...
US20150056205 STEROID SPARING AGENTS AND METHODS OF USING SAME  
This invention relates generally to methods of treating inflammatory bowel diseases (IBD), asthma, Crohn's Disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), graft versus host...
US20140219913 Dual Specific Binding Proteins Having a Receptor Sequence  
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20140065147 Use of Cytokine Expression to Predict Skin Inflammation; Methods of Treatment  
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19,...
US20120276105 USE OF CYTOKINE EXPRESSION TO PREDICT SKIN INFLAMMATION; METHODS OF TREATMENT  
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19,...
US20130195870 ERBB3 Mutations In Cancer  
The present invention concerns somatic ErbB3 mutations in cancer including methods of identifying, diagnosing, and prognosing ErbB3 cancers, as well as methods of treating cancer, including...
US20120076787 COMBINATION OF A TNF-ALPHA ANTAGONIST AND A VEGF ANTAGONIST FOR USE IN THE TREATMENT OR PREVENTION OF DISEASES OF THE EYE  
The invention relates to combinations of TNFα antagonists with VEGF antagonists for use in treating diseases of the eye, and provides antigen-binding proteins which bind to TNFα or a TNFα receptor...
US20130230524 Protein Involved in Ovarian Cancer  
The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including...
US20110059088 Protein involved in ovarian cancer  
The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including...
US20140294826 Methods and compositions with a recombinant neutralizing binding protein for treating toxin exposure  
Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant...
US20120183543 DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS  
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention...
US20120052070 COMPOSITIONS AND METHODS OF USE FOR BINDING MOLECULES TO DICKKOPF-1 OR DICKKOPF-4 OR BOTH  
Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf-1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted...
US20100297127 USE OF IL-27 ANTAGONISTS TO TREAT LUPUS  
This invention relates to methods of treating the autoimmune disorder lupus with IL-27 antagonists, as well as articles of manufacture comprising IL-27 antagonists. The invention also relates to...
US20140161804 BISPECIFIC IMMUNOBINDERS DIRECTED AGAINST TNF AND IL-17  
Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
US20140079705 BISPECIFIC IMMUNOBINDERS DIRECTED AGAINST TNF AND IL-17  
Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
US20130164291 METHOD OF TREATING INFLAMMATORY BOWEL DISEASE  
A method for treating or preventing an inflammatory bowel disease (IBD) in a subject, the method comprising administering to the subject a compound that inhibits granulocyte-macrophage colony...
US20140242081 DOSING REGIMENS FOR TREATMENT OF CEA-EXPRESSING CANCERS  
The present disclosure provides compositions and methods for treating CEA-expressing cancers. Methods for dosing a patient with an antibody that binds to CEA and human CD3 are also provided.
US20130129734 COMPOSITION AND METHODS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LEUKEMIA  
The present disclosure relates generally to compositions and methods for the diagnosis, prognosis and treatment of leukemia, in particular leukemia in which leukemic cells, or neoplastic...
US20110027173 EPHRIN TYPE-A RECEPTOR 10 PROTEIN  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,...
US20150050238 TREATMENT OF OSTEOARTHRITIS AND PAIN  
The present invention relates to the treatment of osteoarthritis and pain using IL-1α and IL-1β binding proteins, including anti-IL-1α and anti-IL-1β antibodies and engineered multivalent and...
US20120251439 Antigens Associated with Inflammatory Bowel Disease Including Ulcerative Colitis  
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of inflammatory bowel disease such as ulcerative colitis...
US20120201822 TUMOR TREATMENT  
The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of...
US20140271457 Dual Specific Binding Proteins Directed Against TNF  
Engineered multivalent and multispecific binding proteins that bind TNFα and IL-13, TNFα and PGE2, or TNFα and NGF are provided, along with methods of making and uses in the prevention, diagnosis,...
US20140112926 Fc VARIANTS  
Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a...
US20120058048 DIRECTED RADIOTHERAPY  
The present invention relates enhanced targeting of drug delivery vehicles to vascular endothelial cells
US20130084293 HISTAMINE-RELEASING FACTOR (HRF), HRF-RECEPTOR AND METHODS OF MODULATING INFLAMMATION  
Methods of treating a food allergy, allergic reactions, hypersensitivity, inflammatory responses, inflammation are provided. In one method, histamine releasing factor (HRF)/translationally...
US20130323246 USE OF MDL-1 ANTAGONISTS TO TREAT SPONDYLARTHROPATHY  
The invention provides methods for treating spondylarthropathy with antagonists of MDL-1 alone or in combination with IL-23 antagonists.
US20150210770 THERAPEUTIC AND DIAGNOSTIC TARGET  
The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of cancer, such as bladder cancer, esophagus cancer, head and neck cancer, lung cancer,...
US20150203592 COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS  
The present invention relates to the treatment of osteoarthritis in a human subject using anti-IL-1α and anti-IL-1β DVD-Ig proteins. In various embodiments, the osteoarthritis includes knee...
US20150037278 INITIAL RELATIVE LYMPHOCYTE COUNT AS PREDICTIVE BIOMARKER  
The invention relates to a method for predicting an improved therapeutic benefit for an individual with a tumor load before initiating an immune therapy which is capable of activating immune cells...
US20130177498 METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY AND DETECTION OF INFLAMMATORY AND IMMUNE-DYSREGULATORY DISEASE, INFECTIOUS DISEASE, PATHOLOGIC ANGIOGENESIS AND CANCER  
Methods and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases, using multispecific antagonists that target at least two different markers are disclosed. The...
US20130108639 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER  
The invention provides a fusion protein comprising (a) a first protein comprising a polypeptide which specifically binds to Annexin A1 and (b) a second protein comprising a polypeptide which...
US20110177075 TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
US20110104256 METHODS FOR TREATING OR PREVENTING COLORECTAL CANCER  
The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and...
US20150125397 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IMMUNE CELL RECEPTORS AND AUTOANTIGENS  
Engineered multivalent and multispecific binding proteins that bind immune cell receptors and/or autoantigens are provided, along with methods of making and uses in the prevention, diagnosis,...
US20110097327 PRODUCT AND METHOD FOR TREATMENT OF CONDITIONS ASSOCIATED WITH RECEPTOR-DESENSITIZATION  
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell...
US20130295098 MULTISPECIFIC EPITOPE BINDING PROTEINS AND USES THEREOF  
The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases.
US20150064186 METHODS OF TREATING LIVER CONDITIONS USING NOTCH2 ANTAGONISTS  
Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include,...
US20140154252 SINGLE-CHAIN MULTIVALENT BINDING PROTEINS WITH EFFECTOR FUNCTION  
Variations on the structural themes for multivalent binding molecules with effector function, or scorpions, will be apparent to those of skill in the art upon review of the present disclosure, and...
US20110059089 Protein Markers for Cardiovascular Events  
The present invention relates to a method for predicting the risk of a subject developing a cardiovascular event comprising detecting at least one biomarker in (a sample of) the cardiovascular...
US20140193333 THERAPEUTIC AND DIAGNOSTIC TARGET  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer,...
US20130164215 COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER  
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the...
US20140302036 PROTEINS SPECIFIC FOR BAFF AND B7RP1  
Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.