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US20140220018 BIOMARKERS FOR EPITHELIAL CANCER DIAGNOSIS AND TREATMENT  
Disclosed herein are methods for diagnosing the state of an epithelial tumor or tissue in a subject. Also disclosed are methods of diagnosing tumor initiation in an epithelial tissue of a subject....
US20120201821 Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma  
The present invention provides methods and means to reduce gastrointestinal inflammation. In particular, the invention provides methods and means to treat inflammatory bowel disease (IBD) and...
US20110217303 ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE, AND/OR FEVER  
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in...
US20110158996 VON WILLEBRAND FACTOR SPECIFIC BINDERS AND METHODS OF USE THEREFOR  
The invention provides new uses for specific binders to the Al domain of the von Willebrand Factor (vWF), in particular the use in patients with stable angina undergoing elective percutaneous...
US20140363493 LIPID NANOPARTICLES FOR TARGETED siRNA DELIVERY  
The present invention addresses a need for improved vehicles for delivering small interfering RNAs (siRNAs).
US20120225070 METHODS FOR TREATING PROGRESSIVE MULTIPLE SCLEROSIS  
The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.
US20130095105 Treatment of Ocular Disease  
Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular...
US20140079702 ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP  
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of...
US20120014955 Antagonists of IL-6 to raise albumin and/or lower CRP  
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of...
US20140037630 METHODS FOR TREATING MICA-RELATED DISORDERS  
Disclosed herein are materials and methods for treating cancer. In particular, the compositions and methods for treating cancers associated with MICA overexpression are provided.
US20140147442 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION  
Methods and compositions comprising antagonists of IL-23 are provided for the treatment of infections, such as chronic bacterial, viral and fungal infections.
US20130302333 PREVENTION AND TREATMENT OF COMPLEMENT-ASSOCIATED EYE CONDITIONS  
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by...
US20120276102 METHODS OF TREATMENT UTILIZIING BINDING PROTEINS OF THE INTERLEUKIN-21 RECEPTOR  
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods...
US20130078246 BIOMARKERS AND METHODS FOR DETECTING AND TREATING SPINAL AND JOINT PAIN  
Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for...
US20130323247 TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA  
The present invention relates to a method for the treatment, amelioration or elimination of acute lymphoblastic leukemia (ALL), the method comprising the administration of a pharmaceutical...
US20130195868 TREATING SURFACE OF THE EYE DISORDERS  
Disclosed herein are methods for administering an IL-1 or IL-17 antagonist for treating ocular surface disorders, e.g., a dry eye disorder. The antagonists can be administered topically using an...
US20110262440 TREATMENT OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA  
The present invention relates to a method for the treatment, amelioration or elimination of pediatric acute lymphoblastic leukemia (ALL), the method comprising the administration of a...
US20150118230 Pharmaceutical Use of FAM19A5 Involved in Regulating Gliogenesis  
The present invention relates to the pharmaceutical use of FAM19A5 involved in regulating gliogenesis, and more specifically, to the use of FAM19A5 in the prevention, diagnosis, or treatment of...
US20120183543 DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS  
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention...
US20110177072 METHODS OF TREATING INFLAMMATION IN NEURONAL TISSUE  
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists...
US20140154250 SINGLE-CHAIN MULTIVALENT BINDING PROTEINS WITH EFFECTOR FUNCTION  
The present disclosure relates to single-chain multivalent binding proteins, compositions comprising the single-chain multivalent binding proteins, and methods of making and using the single...
US20120301404 TREATMENT OF CACHEXIA  
The invention characterizes and provides a receptor for Proteolysis Inducing Factor (PIF) and associated methods and materials employing the same. These have utility, for example, in the provision...
US20130164291 METHOD OF TREATING INFLAMMATORY BOWEL DISEASE  
A method for treating or preventing an inflammatory bowel disease (IBD) in a subject, the method comprising administering to the subject a compound that inhibits granulocyte-macrophage colony...
US20130028897 METHODS FOR REDUCING THE LEVEL OF ALLOANTIBODIES IN A SUBJECT  
The invention provides a method for reducing the level of alloantibodies in a sensitized patient awaiting kidney transplantation by administering Belimumab or an antibody that specifically binds a...
US20110250131 Antigens Associated with Endometriosis, Psoriatic Arthritis and Psoriasis  
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the...
US20110027173 EPHRIN TYPE-A RECEPTOR 10 PROTEIN  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,...
US20120276103 VHH FOR APPLICATION IN TISSUE REPAIR, ORGAN REGENERATION, ORGAN REPLACEMENT AND TISSUE ENGINEERING  
The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.
US20120251439 Antigens Associated with Inflammatory Bowel Disease Including Ulcerative Colitis  
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of inflammatory bowel disease such as ulcerative colitis...
US20120177650 THERAPY FOR ENTERIC INFECTIONS  
A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent with such infections or for preventing...
US20140170146 METHODS FOR MULTIPLEXED DRUG EVALUATION  
Methods for multiplexed delivery of agents to a solid tissue in vivo followed by assessment of efficacy with mass spectrometry are described.
US20110206671 AXON REGENERATION PROMOTER  
An axon regeneration promoter is disclosed that contains an inhibitor of RGM-like protein as an effective component. Inhibitors of RGM-like protein encompass inhibitors of RGM-like protein such as...
US20130183264 Antagonists of IL-6 to raise albumin and/or lower crp  
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of...
US20110250201 ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP  
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of...
US20140242025 MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME  
The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for...
US20110150876 Prognosis and Treatment of Breast Cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
US20110016544 Methods and compositions for detecting and treating retinal diseases based on metargidin (ADAM-15)  
The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD...
US20110171127 NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 162P1E6 USEFUL IN TREATMENT AND DETECTION OF CANCER  
A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
US20120201822 TUMOR TREATMENT  
The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of...
US20110059086 ESPFU NUCLEIC ACIDS AND PROTEINS AND USES THEREOF  
Disclosed are EspFU (EspF-like polypeptide encoded by a gene of the cryptic prophage CP-933U of enterohemorrhagic E. coli) polypeptides, fragments thereof, nucleic acids that encode EspFU...
US20110002845 METHODS OF TREATING, DIAGNOSING OR DETECTING FGF21-ASSOCIATED DISORDERS  
The invention provides, inter alia, methods for treating cancer and vascular disease, compositions for treating cancer and vascular disease, and methods and compositions for diagnosing and/or...
US20140227271 SOMATIC MUTATIONS IN ATRX IN BRAIN CANCER  
We determined the sequence of ATRX and DAXX in 447 cancers from various sites. We found mutations most commonly in pediatric glioblastoma multiformae (GBM) (11.1%), adult GBM (6.5%),...
US20130156766 TREATMENT OF DRY AGE RELATED MACULAR DEGENERATION  
A method of treating dry age related macular degeneration (“AMD”) comprising administration to the eye of an individual in need thereof of a therapeutically effective amount of an anti-endoglin agent.
US20120087859 NANOCARRIER HAVING ENHANCED SKIN PERMEABILITY, CELLULAR UPTAKE AND TUMOUR DELIVERY PROPERTIES  
The present invention relates to a biopolymer-modified nanocarrier in which chitosan is bound to a water-soluble biocompatible polymer that has been crosslinked via a photo-crosslinkable...
US20120269810 METHODS AND COMPOSITIONS FOR PANIC DISORDERS  
Methods and compositions that down regulate the activity of orexins to treat panic disorder and panic-like responses associated with hypercapnic conditions are disclosed.
US20140193412 TREATMENT OF CUTANEOUS WOUNDS BY INHIBITING COLD SHOCK PROTEINS  
Disclosed are methods of treating a subject suffering from a cutaneous wound comprising administering to the subject a CIRP inhibitor.
US20130177562 METHODS OF ANTAGONIZING SIGNAL TRANSDUCTION IN DORSAL ROOT GANGLION CELLS  
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists...
US20130084293 HISTAMINE-RELEASING FACTOR (HRF), HRF-RECEPTOR AND METHODS OF MODULATING INFLAMMATION  
Methods of treating a food allergy, allergic reactions, hypersensitivity, inflammatory responses, inflammation are provided. In one method, histamine releasing factor (HRF)/translationally...
US20150210770 THERAPEUTIC AND DIAGNOSTIC TARGET  
The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of cancer, such as bladder cancer, esophagus cancer, head and neck cancer, lung cancer,...
US20140056894 RSPONDINS AS MODULATORS OF ANGIOGENESIS AND VASCULOGENESIS  
The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors or modulators of Rspondin e.g....
US20120070406 THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY  
The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical...