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US20120052010 |
IMAGING TUMOR PERFUSION, OXIDATIVE METABOLISM USING DYNAMIC ACE PET IN PATIENTS WITH HEAD AND NECK CANCER DURING RADIOTHERAPY
The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo... |
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US20120207678 |
Labeled Adenosine for Use in Positron Emission Tomography
Radiolabeled adenosine or radiolabeled adenosine containing molecules for use in positron emission tomography for assessing alterations in adenylate metabolism in a patient are provided. |
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US20130224114 |
Translocator Protein Ligands
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the... |
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US20110044898 |
TRANSLOCATOR PROTEIN LIGANDS
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the... |
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US20130183240 |
IN VIVO IMAGING METHOD FOR CANCER
The present invention provides a method useful in the diagnosis and monitoring of cancer wherein there is an abnormal expression of PBR. The method of the invention is particularly useful in... |
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US20120107240 |
Probes and methods of melanoma imaging
Embodiments of the present disclosure provide for labeled probes such as a 3-18F-fluoropicolinamide probe, methods of making labeled probes, pharmaceutical compositions including labeled probes,... |
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US20130183238 |
Formulation, Apparatus and Method for Stabilizing Radiopharmaceuticals
A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a... |
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US20120020881 |
Triaryl-sulphonium compounds, kit and methods for labeling positron emitting isotopes
This invention relates to novel compounds suitable for labeling by positron emitting isotopes, such as 18F, 11C, 13N and 15O, through appropriate labeling reagents, such as 18F reagents and... |
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US20110293520 |
NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of... |
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US20130084245 |
PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY
The present invention provides methods of monitoring Aβ-directed immunotherapy. The methods involve administering a PET ligand that binds to amyloid deposits and detecting the PET ligand in the... |
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US20140079635 |
MOLECULAR PROBES FOR DETECTING LIPID COMPOSITION
A method of detecting myelin in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative and detecting the amount or distribution of... |
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US20130164217 |
METHOD OF DIAGNOSING, PREVENTING AND/OR TREATING DEMENTIA & RELATED DISORDERS
Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild... |
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US20150023877 |
METHODS OF PARKINSONS DISEASE DIAGNOSIS AND MONITORING TREATMENT
Embodiments of the present disclosure provide for methods of using labeled probes, methods of diagnosing Parkinson's disease and related biological events, methods of using labeled probes for... |
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US20140170067 |
NEW LIGANDS FOR TARGETING OF S1P RECEPTORS FOR IN VIVO IMAGING AND TREATMENT OF DISEASES
The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P... |
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US20110070160 |
Dose Synthesis Mosule for Biomaker Generator System
A microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, one (1) unit dose of a radiopharmaceutical biomarker for use in positron... |
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US20150231279 |
METHODS AND COMPOSITIONS FOR DETECTING DRUSEN AND PREDICTING AGE-RELATED MACULAR DEGENERATION
Labels and methods are provided for detecting deposits, including drusen, sub-retinal deposits, basal laminar and linear deposits, and the like. The labels can detect the presence, progression, or... |
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US20130336890 |
COMPOUNDS FOR USE IN IMAGING, DIAGNOSING AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the... |
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US20150157743 |
Dose Synthesis Card for Use with Automated Biomarker Production System
Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron... |
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US20110189089 |
RADIOFLUORINATION
The present invention relates to 18F radio-chemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in... |
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US20130101509 |
IMAGING AND RADIOTHERAPY METHODS
The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of... |
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US20110286922 |
IMAGING AND RADIOTHERAPY METHODS
The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of... |
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US20150133777 |
POSITRON EMISSION TOMOGRAPHY PROBE TO MONITOR SELECTED SUGAR METABOLISM IN VIVO
The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods... |
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US20130028837 |
CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds... |
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US20120276006 |
CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds... |
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US20150079001 |
IMAGING AGENTS AND METHODS OF IMAGING NAALADASE OR PSMA
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of... |
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US20120276007 |
IMAGING AGENTS AND METHODS OF IMAGING NAALADASE OR PSMA
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of... |
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US20100310457 |
IMAGING OF MYELIN BASIC PROTEIN
The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering... |
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US20130101510 |
METHODS OF TREATING PARKINSON'S DISEASE USING VIRAL VECTORS
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease. |
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US20120039803 |
PRETARGETING KIT, METHOD AND AGENTS USED THEREIN
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal... |
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US20130177501 |
IN VIVO IMAGING METHOD OF MOOD DISORDERS
The present invention provides a method useful in the diagnosis and/or monitoring of mood disorders wherein there is an abnormal expression of PBR. The method of the invention is useful in the... |
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US20110142759 |
AGENTS AND METHODS FOR THE IMAGING OF MYELIN BASIC PROTEIN
The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying... |
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US20120121509 |
VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE
The present invention provides compositions and methods based on vital fluorochrome conjugates that are useful for imaging dying and dead cells. |
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US20130266512 |
Tetrazine-trans-cyclooctene Ligation for the Rapid Construction of Radionuclide Labeled Probes
A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ... |
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US20130302248 |
Imaging Agents for Detecting Neurological Disorders
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and... |
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US20110182812 |
Imaging Agents for Detecting Neurological Disorders
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins... |
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US20150010474 |
Compounds And Methods For Selective Imaging And/Or Ablation
The invention relates generally to compounds and methods for imaging and/or selective ablation of nitroreductase-expressing cells and/or biological agents. More particularly, although not... |
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US20140134107 |
COMPOUNDS, PROBES, AND METHODS OF SYNTHESIS AND METHODS OF IMAGING COX-2-ASSOCIATED DISEASES
Embodiments of the present disclosure provide for a compound, methods of making a compound, a probe, methods of making a probe, pharmaceutical compositions including a probe or a compound, methods... |
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US20140341808 |
CONTRAST AGENT FOR IMAGINING MYOCARDIAL PERFUSION
Compounds and a method for imaging myocardial perfusion, including administering to a patient a compound linked to an imaging moiety, wherein the compound binds MC-1, and scanning the patient... |
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US20120294803 |
CXCR4 ANTAGONISTS FOR IMAGING OF CANCER AND INFLAMMATORY DISORDERS
The invention provides radiolabeled CXCR4 antagonists, compositions and methods of use for imaging of chemokine CXCR4 receptors and biological conditions associated with the expression of CXCR4... |
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US20140335019 |
COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS
Provided herein are compositions and methods for the treatment and analysis of neurological disorders. In particular, provided herein are small molecules targeted to amyloid-β (Aβ) or metal-Aβ... |
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US20130209363 |
METHOD FOR PRODUCTION OF F-18 LABELED AMYLOID BETA LIGANDS
This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives. |
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US20120213703 |
RADIOLABELLED PDE10 LIGANDS
The present invention relates to novel, selective, radiolabelled PDE10 ligands which are useful for imaging and quantifying the PDE10A enzyme in tissues, using positron-emission tomography (PET).... |
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US20110305637 |
RADIOLABELLED PDE10 LIGANDS
The present invention relates to novel, selective, radiolabeled PDE10 ligands which are useful for imaging and quantifying the PDE10A enzyme in tissues using positron-emission tomography (PET).... |
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US20150023873 |
EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies... |
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US20140004044 |
USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING
The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including for the treatment of... |
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US20110008254 |
RADIOPHARMACEUTICAL COMPOSITION
The present invention relates to radiopharmaceuticals and in particular to a radiopharmaceutical composition comprising a compound of Formula (I): and polysorbate as an excipient. The... |
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US20130259805 |
DEVELOPMENT AND SCREENING OF CONTRAST AGENTS FOR IN VIVO IMAGING OF PARKINSON'S DISEASE
The invention provides compounds and a method for imaging aggregated α-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ. |
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US20090257949 |
Radiopharmaceutical Imaging of Neurodegenerative Diseases
Methods for simultaneously detecting dementia or cognitive impairment, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Dementia (LBD) and Vascular Dementia (VaD) in a patient... |
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US20130343994 |
Cholinesterase Inhibitors
The invention provides compounds that inhibit cholinesterases, such as acetylcholinesterase and butyrylcholinesterase. Such compounds are useful to prevent or treat exposure of a patient (e.g., a... |
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US20120321561 |
CANCER DIAGNOSIS AND IMAGING
The present invention provides a method for imaging a disease or condition in a mammal which includes the steps of; administering a therapeutically effective amount of a cell cycle inhibitor to... |