Matches 1 - 48 out of 48


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US20110142756 Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer  
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
US20110008252 STABALISED 99MTC COMPOSITIONS  
The present invention relates to stabilised 99mTc radiopharmaceutical compositions of the ligand tetrofosmin, which include an ascorbic acid or ascorbate radioprotectant, in the absence of an...
US20120039803 PRETARGETING KIT, METHOD AND AGENTS USED THEREIN  
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
US20150132222 METHODS AND COMPOSITIONS FOR POSITRON EMISSION TOMOGRAPHY MYOCARDIAL PERFUSION IMAGING  
This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of...
US20130064768 LIPOPHILIC CATIONIC PROBE FOR PET-IMAGING  
The present invention provides an imaging probe which comprises a lipophilic cation, a hydrophobic moiety and a PET nucleus. The present invention also provides a precursor molecule for the...
US20120156133 NON-RADIOACTIVE PHOSPHOLIPID COMPOUNDS, COMPOSITIONS, AND METHODS OF USE  
The present invention provides phospholipid ether and alkyl phospholipid compounds and their combinations with other cancer therapy agents. More specifically, the invention relates to the use of...
US20110064661 NON-RADIOACTIVE PHOSPHOLIPID COMPOUNDS, COMPOSITIONS, AND METHODS OF USE  
The present invention provides phospholipid ether and alkyl phospholipid compounds and their combinations with other cancer therapy agents. More specifically, the invention relates to the use of...
US20140178298 METHODS FOR TUMOR DIAGNOSIS AND THERAPY  
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
US20080075660 Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications  
The present invention provides composition and methods of use of phospholipid dyes for use in detection of neoplastic tissue, typically using the routing procedure of endoscopy and methods of...
US20100236958 RADIOPHARMACEUTICAL COMPOSITION  
The present invention provides a 99mTc-tetrofosmin radiopharmaceutical composition comprising tetrofosmin and a radioprotectant at a particular range of molar ratios. A kit and a multi-dose kit...
US20130052133 SE-72/AS-72 GENERATOR SYSTEM BASED ON SE EXTRACTION/ AS REEXTRACTION  
The preparation of a 72Se/72As radioisotope generator involves forming an acidic aqueous solution of an irradiated alkali bromide target such as a NaBr target, oxidizing soluble bromide in the...
US20090238759 Method of Rapid Methylation of Alkene Compound and Kit for PET Tracer Preparation Using the Same  
To provide a method of rapid methylation of alkenes, which is applicable to the preparation of a PET tracer and which enables alkenes to be methylated through cross coupling between SP2 (alkenyl)...
US20100098632 HYDROXYAPATITE PARTICLES  
This document provides methods and materials related to hydroxyapatite particles. For example, hydroxyapatite particles, methods for making hydroxyapatite particles, and methods for using...
US20110064660 DEUTERATED ALKYL PHOSPHOLIPID COMPOUNDS, COMPOSITIONS, AND METHODS OF USE  
The invention generally relates to novel deuterated phospholipid compounds, compositions comprising these compounds, and their use in a variety of cancer therapy and diagnostic applications.
US20150030538 PHOSPHOLIPID ETHER ANALOGS AS AGENTS FOR DETECTING AND LOCATING CANCER, AND METHODS THEREOF  
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting...
US20140030187 PHOSPHOLIPID ETHER ANALOGS AS AGENTS FOR DETECTING AND LOCATING CANCER, AND METHODS THEREOF  
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting...
US20140079632 ACTIVITY-BASED PROBES FOR THE UROKINASE PLASMINOGEN ACTIVATOR  
The present invention relates to selective trypsine-like serine protease activity-based probes, in particular urokinase plasminogen activator-activity based probes, the use thereof and methods for...
US20120328518 PROSTATE SPECIFIC MEMBRANE ANTIGEN INHIBITORS  
This invention relates to novel compounds suitable for labelling by 18F and the corresponding 18F labelled compounds themselves, 19F-fluorinated analogues thereof and their use as reference...
US20090117041 Radiologic Agents for Monitoring Alzheimer's Disease Progression and Evaluating a Response to Therapy and Processes for the Preparation of Such Agents  
Disclosed are certain cycloSalingenyl pyrimidine nucleoside monophosphates comprising positron emitters or gamma-emitting radiohalides, uses thereof for monitoring Alzheimer's disease progression...
US20080181847 Targeted Imaging and/or Therapy Using the Staudinger Ligation  
The use of a selective chemical and bioorthogonal reaction providing a covalent ligation such as the Staudinger ligation, in targeted molecular imaging and therapy is presented, more specifically...
US20100316567 ETHER AND ALKYL PHOSPHOLIPID COMPOUNDS FOR TREATING CANCER AND IMAGING AND DETECTION OF CANCER STEM CELLS  
Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
US20140199240 ANTICANCER AGENT  
The invention relates to a method for preparing a bisphosphonate covalently bonded to a nanostructure. This invention also relates to a bisphosphonate having incorporated therein a radioisotope...
US20130280165 MICROSPHETRE COMPRISING A LANTHANIDE METAL COMPLES  
The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension...
US20100221180 IN VIVO IMAGING OF MYELINATION  
A molecular probe for labeling myelin includes a fluorescent stilbenzene derivative.
US20140241985 Chelated PSMA Inhibitors  
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention...
US20130343991 ETHER AND ALKYL PHOSPHOLIPID COMPOUNDS FOR TREATING CANCER AND IMAGING AND DETECTION OF CANCER  
Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
US20150093330 PHOSPHOLIPID ANALOGS AS DIAPEUTIC AGENTS AND METHODS THEREOF  
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
US20140023587 PHOSPHOLIPID ANALOGS AS DIAPEUTIC AGENTS AND METHODS THEREOF  
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
US20120148492 BISPHOSPHONIC ACID DERIVATIVE AND COMPOUND THEREOF LABELED WITH RADIOACTIVE METAL NUCLIDE  
Disclosed is a radioactive bone diagnostic agent which gives a high ratio of radioactivity accumulation in bone to that in blood from an early stage after administration of the agent and allows...
US20100215578 Catalytic Radiofluorination  
One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18...
US20140010758 PEPTIDOMIMETIC INHIBITORS OF PSMA  
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2)...
US20100202965 ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS  
The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula...
US20090311178 PYRROLINIDIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS  
Compounds of formula (I) in salt or zwitterionic form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by...
US20080138280 Composition and Methods For Inhibiting Cell Survival  
The present invention is directed to compositions and methods of making and using compositions that are useful for treating cells or conditions caused or exacerbated by cell survival mechanisms of...
US20170129970 IMPROVED POPPET FOR CRYOGENIC FLUID COUPLING  
Subject polymers have a plurality of repeating units having amino-bis-phosphonate functionality pendent groups of a polyacrylate, polymethacrylate, polyacrylamide, polymethacrylamide, or linear...
US20170072075 Chelated PSMA Inhibitors  
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention...
US20170022224 HBED-Bisphosphonates, Radiometal Conjugates and Their Use as Theranostic Agents  
The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with 68Ga displayed excellent bone uptake and...
US20160310621 IMAGING PROBES, FORMULATIONS, AND USES THEREOF  
Described herein are single and dual modality bisphosphonate conjugated imaging probes. Also described herein are methods of synthesizing and using the single and dual modality bisphosphonate...
US20160296646 ALKYLPHOSPHOCHOLINE ANALOGS FOR MULTIPLE MYELOMA IMAGING AND THERAPY  
It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells. The alkylphophocholine analogs are compounds having the formula:...
US20160279273 MICROSPHERE COMPRISING A LANTHANIDE METAL COMPLEX  
The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number of the microspheres, a suspension...
US20160271279 PHARMACEUTICAL COMPOSITION  
This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition...
US20160228588 ETHER AND ALKYL PHOSPHOLIPID COMPOUNDS FOR TREATING CANCER AND IMAGING AND DETECTION OF CANCER  
Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
US20160193235 Mitochondrially-Targeted Electrophilic Compounds and Methods of Use for the Treatment of Cancer  
The present invention provides methods, compounds, compositions and kits including mitochondrially-targeted electrophilic (MTE) compounds that are useful for treating cancer.
US20160185805 PROBE FOR IMAGING PARP-1 ACTIVITY  
Provided are embodiments of a small molecule tracer for positron emission tomography (PET) imaging of the enzyme activity of PARP-1 that is responsible for DNA-damage sensing and critically...
US20160158390 Methods for Tumor Diagnosis and Therapy  
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
US20150374857 Method for predicting autism spectrum disorders by cannabinoid and cannabinoid receptor expression  
The inventive method relates to a method for the determination of susceptibility or diagnosis of autism or autism spectrum disorders. Diagnosis or determination of susceptibility determinations...
US20150283273 Catalytic Radiofluorination  
One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18...
US20150273086 HYPERPOLARIZED 2-OXOGLUTARATE AS METABOLIC AGENT IN MR  
Hyperpolarized 1-13C-2-oxoglutarate as contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said...

Matches 1 - 48 out of 48