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US20130095037 PEPTIDE DERIVATIVES OF EXENDIN-4  
In the current invention peptides, which are derived from GLP-1 (glucagon-like peptide-1) and exendin-3 and/or exendin-4, are provided which bond to the GLP-1 receptor and can be used, labeled or...
US20120039802 PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (CMET) AND USES THEREOF  
A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
US20110206606 STABLE RADIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR PREPARATION  
Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that...
US20100260672 PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (CMET) AND USES THEREOF  
A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
US20100158803 Production and Use of Novel Peptide-Based Agents for Use with Bi-Specific Antibodies  
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against...
US20080138278 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO) CHLOROHYLL PHOTOSYNTHESIZERS AND THEIR USES  
Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT),...
US20060233707 Process for producing an injectable medicament preparation  
The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of...
US20050207976 High energy phototherapeutic agents  
A high energy phototherapeutic agents or radiosensitizer agent comprised of a halogenated xanthene, or an agent that exhibits a preference for concentration in biologically sensitive structures in...
US20160151504 PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES  
A method of penetrating a cell where the cell is contacted with a complex that includes (A) a peptide comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the...
US20150182588 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES  
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions...
US20130089498 COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELLS BASED ON PEPTIDE BINDING  
Methods and compositions are described for classifying cells and/or peptides that associate or bind with a particular characteristic pattern to a plurality of cells or cell lines. Aspects of the...
US20120034164 TRUNCATED CAR PEPTIDES AND METHODS AND COMPOSITIONS USING TRUNCATED CAR PEPTIDES  
Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods...
US20100047168 Soluble Zcytor 11 Cytokine Receptors  
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zcytor11 receptors that may be used as novel cytokine...
US20080118432 Monitoring cancer stem cells  
The present invention is directed to methods of monitoring cancer stem cells in patients undergoing cancer therapy to determine whether the cancer therapy is an effective cancer therapy. The...
US20070231257 Gastrin Releasing Peptide Compounds  
New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or...
US20070041904 Peptides whose uptake by cells is controllable  
A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A...
US20060246005 Poly(peptide) as a chelator: methods of manufacture and uses  
Novel compositions for imaging that include (a) a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions and (2) a valent metal...
US20050175582 Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system  
A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity...
US20110280802 Linkers For Radiopharmaceutical Compounds  
A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a...
US20110229409 LINKABLE LEWIS X ANALOGS  
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable...
US20070258893 Compositions and methods for imaging expression of cell surface receptors  
The present disclosure provides imaging agents and methods for imaging surface cell receptors, particularly CXCR4 receptors and biological conditions associated with the expression of CXCR4...
US20070065362 Gastrin receptor-avid peptide conjugates  
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin...
US20050100963 KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy  
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever...
US20150010473 DIAGNOSIS AND TREATMENT OF TUMORS  
The present invention is directed to methods and compositions for the treatment and diagnosis of neuroectodermally-derived tumors, such as gliomas. The inventive methods of treatment generally...
US20130156697 ISOLATED PROTEIN MEDICAMENT  
The invention in suitable embodiments is directed to an isolated protein comprising one or more amino acid sequences, each amino acid sequence capable of being functionalized and/or attached in...
US20120128587 FOLATE-TARGETED DIAGNOSTICS AND TREATMENT  
Methods of detecting and assessing functionally active folate receptors on tumors and treatment associated with those tumors are described. Also described are methods of selecting ovarian and lung...
US20120076728 HUMAN PROTEIN SCAFFOLD WITH CONTROLLED SERUM PHARMACOKINETICS  
This invention provides constructs comprising a protein scaffold, wherein the scaffold comprises Domain III, Domain IIIa, or Domain IIIb of human serum albumin or a polypeptide having substantial...
US20100215576 DIAGNOSIS AND TREATMENT OF NEUROECTODERMAL TUMORS  
The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or...
US20100215575 Systemic Administration of Chlorotoxin Agents for the Diagnosis and Treatment of Tumors  
The present invention is directed to methods and compositions for the treatment and diagnosis of neoplastic tumors. The inventive methods generally include systemic (e.g., intravenous)...
US20100098627 PROTEINS  
The present invention provides methods and compositions for treatment, prevention, diagnosis and monitoring of colorectal cancer, kidney cancer, lung cancer and/or pancreatic cancer in particular...
US20070237714 Diagnosis and treatment of tumors  
The present invention is directed to methods and compositions for the treatment and diagnosis of neuroectodermally-derived tumors, such as gliomas. The inventive methods of treatment generally...
US20150004099 TARGETING OF CHONDROITIN SULFATE GLYCANS  
The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding...
US20140140925 FOLATE-TARGETED DIAGNOSTICS AND TREATMENT  
Methods of detecting and assessing functionally active folate receptors on tumors and treatment associated with those tumors are described. Also described are methods of selecting ovarian and lung...
US20100266499 CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS  
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors...
US20090148382 Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof  
One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence...
US20080213175 Click chemistry-derived cyclic peptidomimetics as integrin markers  
The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic...
US20080166294 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR OF HEMATOPOIETIC ORIGIN  
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
US20060140858 Drug pre-targeting by means of bi-specific antibodies and hapten constructs comprising a carrier peptide and the active agent(s)  
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at...
US20150151001 COMPOSITIONS AND METHODS FOR DETECTING OR ELIMINATING SENESCENT CELLS TO DIAGNOSE OR TREAT DISEASE  
Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells...
US20150104388 ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE  
This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1...
US20120009124 USE OF BUFFERS FOR RADIONUCLIDE COMPLEXATION  
The present invention relates to a method for complexation of a chelate with a radionuclide, advantageously gallium, the complexation being carried out advantageously at ambient temperature...
US20100215572 METHODS OF TREATMENT USING LDCAM  
The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and...
US20070269375 Stable Radiopharmaceutical Compositions and Methods for Preparation  
Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that...
US20060263293 Click chemistry method for synthesizing molecular imaging probes  
The present disclosure provides a method for preparing a radioactive ligand or radioactive substrate having affinity for a target biomacromolecule, the method comprising: (a) reacting a first...
US20100098628 PROTEINS  
The present invention relates to the identification of membrane proteins associated with B-cell non-Hodgkin's lymphoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer,...
US20080279768 Bifunctional Metal Chelating Conjugates  
The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostics or therapeutic agents. Specifically, conjugates of the present invention include a...
US20070253902 Treatment for inflammatory bowel disease  
A method for the treatment of inflammatory bowel disease (IBD) is disclosed. The method comprises administration of an antibody, polypeptide or other molecule recognizing VLA-4, a surface molecule...
US20170137495 TIMP3 AS VEGF INHIBITOR  
Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (TIMP3) or variants of TIMP3 can be used to substantially inhibit vascular endothelial growth factor (VEGF) binding to...
US20170066807 LIPOCALIN MUTEINS WITH BINDING-AFFINITY FOR GLYPICAN-3 (GPC-3) AND USE OF LIPOCALIN MUTEINS FOR TARGET-SPECIFIC DELIVERY TO CELLS EXPRESSING GPC-3  
The present invention relates to novel, specific-binding therapeutic and/or diagnostic lipocalin muteins directed against Glypican-3 (GPC-3). The invention also relates to nucleic acid molecules...
US20160009770 LIPID-PEPTIDE-POLYMER CONJUGATES AND NANOPARTICLES THEREOF  
The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer...

Matches 1 - 50 out of 284 1 2 3 4 5 6 >