Title:
Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them
Kind Code:
A1


Abstract:
Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them.

Diacyl-substituted guanidines of the formula I 1embedded image

are described

where

X(1) and X(2) are 2embedded image

T1 is zero, 1, 2, 3 or 4,

R(A) and R(B) are hydrogen, Hal, CN, OR(106), (O) (cyclo)—(fluoro)alkyl, NR(107)R(108), phenyl or benzyl,

or 3embedded image

T2a and T2b are, independently of each other, zero, 1 or 2,

where the double bond can be in the E or Z configuration;

or

X(1) and X(2) are 4embedded image

as are the pharmaceutically tolerated salts thereof. They are outstandingly suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the elicitation of ischemically induced cardiac arrhythmias. On account of their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I according to the invention can, as a consequence of inhibiting the cellular Na+/H+ exchange mechanism, be used as pharmaceuticals for treating all acute or chronic damage elicited by ischemia, or diseases induced primarily or secondarily thereby.




Inventors:
Kleemann, Heinz-werner (Bad Homburg, DE)
Lang, Hans-jochen (Hofheim, DE)
Weichert, Andreas (Egelsbach, DE)
Crause, Peter (Offenbach, DE)
Scholz, Wolfgang (Eschborn, DE)
Albus, Udo (Florstadt, DE)
Schwark, Jan-robert (Frankfurt, DE)
Application Number:
10/641058
Publication Date:
03/04/2004
Filing Date:
08/15/2003
Assignee:
Hoechst Aktiengesellschaft
Primary Class:
Other Classes:
564/147
International Classes:
A61K31/155; A61K31/185; A61P9/00; A61P9/10; C07C277/08; C07C279/20; C07C279/22; C07C311/37; C07C311/59; C07C315/04; C07C317/32; C07C317/44; C07C323/65; C07C323/67; C07D207/327; C07D215/54; C07D231/12; C07D233/60; C07D233/61; C07D295/10; C07D295/155; C07D521/00; (IPC1-7): A61K31/16; A61K31/165
View Patent Images:
Related US Applications:



Primary Examiner:
O SULLIVAN, PETER G
Attorney, Agent or Firm:
FINNEGAN, HENDERSON, FARABOW, GARRETT & DUNNER (LLP 901 NEW YORK AVENUE, NW, WASHINGTON, DC, 20001-4413, US)
Claims:
1. A diacyl-substituted guanidine of the formula I 127embedded image in which: X(1) and X(2) are 128embedded image T1 is zero, 1, 2, 3 or 4, R(A) and R(B) are, independently, hydrogen, F, Cl, Br, I, CN, OR(106), (C1-C8)-alkyl, (C3-C8)-cycloalkyl, Ozk(CH2)zlCzmF2zm+1, NR(107)R(108), phenyl or benzyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(109)R(110), R(109) and R(110) being hydrogen, (C3-C4)-alkyl or (C1-C4)-perfluoroalkyl, zl is zero, 1, 2, 3 or 4, zk is zero or 1, zm is 1, 2, 3, 4, 5, 6, 7 or 8, R(106) is hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl, (C3-C8)-alkenyl, (C3-C8)-cycloalkyl, phenyl or benzyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(111)R(112), R(111) and R(112) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, R(107) and R(108) are, independently of each other, defined as R(106), or R(107) and R(108) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, or X(1) and X(2) are 129embedded image T2a and T2b are, independently of each other, zero, 1 or 2, where the double bond can have the E or Z configuration; or X(1) and X(2) are 130embedded image T3 is zero, 1 or 2, U, YY and Z are, independently of each other, C or N, where U, YY and Z can carry the following number of substituents: 8
Bonded to a doubleNumber of permitted
U, YY or Zbond in the ringsubstituents
Cyes1
Cno2
Nyes0
Nno1
R(D) is hydrogen, (C1-C8)-alkyl or (C1-C8)-perfluoroalkyl, R(U1), R(U2), R(Y1), R(Y2), R(Z1) and R(Z2) are, independently of each other, hydrogen, F, Cl, Br, I, CN, OR(114), (C1-C8)-alkyl, (C3-C8)-cycloalkyl, Ozka(CH2)zlaCzmaF2zma+1, NR(115)R(116), phenyl or benzyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(117)R(118), R(117) and R(118) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, zka is zero or 1, zla is zero, 1, 2, 3 or 4, zma is 1, 2, 3, 4, 5, 6, 7 or 8, R(114) is hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl, (C3-C8)-alkenyl, (C3-C8)-cycloalkyl, phenyl or benzyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119)R(120), R(119) and R(120) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, R(115) and R(116) are, independently of each other, defined as R(114), or R(115) and R(116) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, where, however, the constitution U is nitrogen (N), YY is nitrogen (N) and Z is carbon (C) is excepted, R(101), R(102), R(103), R(104) and R(105) are, independently of each other, hydrogen, F, Cl, Br, I, —C≡N, Xzoa—(CH2)zpa—(CzqaF2zqa+1), R(110a)-SOzbm, R(110b)R(110c)N—CO, R(111a)-CO— or R(112a)R(113a)N—SO2—, where the perfluoroalkyl group is straight-chain or branched, X is hydrogen, S or NR(114a), zoa is zero or 1, R(114a) being H or (C1-C3)-alkyl, zbm is zero, 1 or 2, zpa is zero, 1, 2, 3 or 4, zqa is 1, 2, 3, 4, 5, 6, 7 or 8, R(110a), R(110b), R(111a) and R(112a) are, independently, (C1-C8)-alkyl, (C3-C8)-alkenyl, —CznH2zn—R(115a) or (C1-C8)-perfluoroalkyl, zn is zero, 1, 2, 3 or 4, R(115a) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a), R(116a) and R(117a) being hydrogen, (C1-C4)-perfluoroalkyl or (C1-C4)-alkyl, or R(110b), R(111a) and R(112a) are also hydrogen, R(110c) and R(113a) are, independently, hydrogen, (C1-C4)-perfluoroalkyl or (C1-C4)-alkyl, or R(110b) and R(110c) and also R(112a) and R(113a) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, (C1-C8)-alkyl, —CzalH2zalR(118a) or (C3-C8)-alkenyl, zal is zero, 1, 2, 3 or 4, R(118a) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(119a)R(119b), R(119a) and R(119b) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, —C≡C—R(193), R(193) is phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(194)R(195), R(194) and R(195) being hydrogen or CH3, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, —Y-para-C6H4—(CO)zh—(CHOH)zi—(CH2)zj—(CHOH)zk—R(123), —Y-meta-C6H4—(CO)zad—(CHOH)zae—(CH2)zaf—(CHOH)zag—R(124) or —Y-ortho-C6H4—(CO)zah—(CHOH)zao—(CH2)zap—(CHOH)zak—R(125), Y is oxygen, —S— or —NR(122d)-, zh, zad and zah are, independently, zero or 1, zi, zj, zk, zae, zaf, zag, zao, zap and zak are, independently, zero, 1, 2, 3 or 4, where, however, in each case, zh, zi and zk are not simultaneously zero, zad, zae and zag are not simultaneously zero, zah, zao and zak are not simultaneously zero, R(123), R(124), R(125) and R(122d) are, independently, hydrogen or (C1-C3)-alkyl, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, SR(129), —OR(130), —NR(131)R(132) or —CR(133)R(134)R(135), R(129), R(130), R(131) and R(133), are, independently, —CzabH2zab—(C1-C9)-heteroaryl which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino, zab is zero, 1 or 2, R(132), R(134) and R(135) are, independently of each other, defined as R(129), or hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, —W-para-(C6H4)—R(196), —W-meta-(C6H4)—R(197) or —W-ortho-(C6H4)—R(198), R(196), R(197) and R(198) are, independently, (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1 to 3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino, dimethylamino and benzyl, W is oxygen, S or NR(136)-, R(136) being hydrogen or (C1-C4)-alkyl, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, R(146)X(1a)-, X(1a) is oxygen, S, NR(147), (D=O)A- or NR(148)C=MN(*)R(149)-, M is oxygen or sulfur, A is oxygen or NR(150), and D is C or SO, R(146) is (C1-C8)-alkyl, (C3-C8)-alkenyl, (CH2)zbz—CzdzF2zdz+1 or —CzxaH2zxa—R(151) zbz is zero or 1, zdz is 1, 2, 3, 4, 5, 6 or 7, zxa is zero, 1, 2, 3 or 4, R(151) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(152)R(153), R(152) and R(153) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, R(147), R(148) and R(150) are, independently, hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl, R(149) is defined as R(146), or R(146) and R(147), or R(146) and R(148), respectively, are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl, where A and N(*) are bonded to the phenyl nucleus of the alkanoyl parent substance, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, —SR(164), —OR(165), —NHR(166), —NR(167)R(168), —CHR(169)R(170), —CR(154)R(155)OH, —C≡CR(156), —CR(158)=CR(157) or —[CR(159)R(160)]zt-(C≡O)—[(CR(161)R(162)]zv-R(163), R(164), R(165), R(166), R(167) and R(169) are identical or different and are —(CH2)zy—(CHOH)zz—(CH2)zaa—(CHOH)zt—R(171) or —(CH2)zab—(CH2—CH2O)zac—R(172) R(171) and R(172) being hydrogen or methyl, zu is 1, 2, 3 or 4, zv is zero, 1, 2, 3 or 4, zy, zz, zaa, zab and zac are identical or different and are zero, 1, 2, 3 or 4, zt is 1, 2, 3 or 4, R(168), R(170), R(154) and R(155) are identical or different and are hydrogen or (C1-C6)-alkyl, or R(169) and R(170), or R(154) and R(155), respectively, are, together with the carbon atom carrying them, a (C3-C8)-cycloalkyl, R(163) is hydrogen, (C1-C6)-alkyl, (C3-C8)-cycloalkyl or —CzebH2zeb—R(173), zeb is zero, 1, 2, 3 or 4, R(156), R(157) and R(173) are, independently, phenyl which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(174)R(175), R(174) and R(175) being hydrogen or (C1-C4)-alkyl, or R(156), R(157) and R(173) are, independently, (C1-C9)-heteroaryl which is unsubstituted or is substituted as phenyl, R(158), R(159), R(160), R(161) and R(162) are hydrogen or methyl, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, R(176)-NH—SO2—, R(176) is R(177)R(178)N—(C═Y′)—, Y, is oxygen, S or N—R(179), R(177) and R(178) are identical or different and are hydrogen, (C1-C8)-alkyl, (C3-C6)-alkenyl or —CzfaH2zfa—R(180) zfa is zero, 1, 2, 3 or 4, R(180) is (C5-C7)-cycloalkyl or phenyl which is unsubstituted or substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methoxy or (C1-C4)-alkyl, or R(177) and R(178) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl, R(179) is defined as R(177) or is amidine, or R(101), R(102), R(103), R(104) and R(105) are, independently of each other, NR(184a)R(185), OR(184b), SR(184c) or —CznxH2znx—R(184d), znx is zero, 1, 2, 3 or 4, R(184d) is (C3-C7)-cycloalkyl or phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116k)R(117k), R(116k) and R(117k) being hydrogen or (C1-C4)-alkyl, R(184a), R(184b), R(184c) and R(185) are, independently of each other, hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl or (CH2)zao—R(184g), zao is zero, 1, 2, 3 or 4, 184g is (C3-C7)-cycloalkyl or phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(184u)R(184v), R(184u) and R(184v) being hydrogen or (C1-C4)-alkyl, or R(184a) and R(185) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl, and also pharmaceutically tolerated salts thereof, where, however, the following compounds are excepted: 131embedded image and where, additionally, the compounds are excepted in which the radicals R(1) to R(5) are combined as follows: 9
R(101)R(102)R(103)R(104)R(105)R(105)R(104)R(103)R(102)R(101)
[X(1)][X(1)][X(1)][X(1)][X(1)][X(2)][X(2)][X(2)][X(2)][X(2)]
HClClHHHHClClH
HHNH2HHHHNH2HH
HHHHHHHHHH
ClHHHHHHHHCl
HHClHHHHClHH
HHCH3HHHHCH3HH
HHNH2HHHHHHH
HHClHHHHHHH
HHCH3HHHHHHH


2. A compound of the formula I as claimed in claim 1, wherein X(1) is identical to X(2) and wherein the remaining substituents are defined as in claim 1.

3. A compound of the formula I as claimed in claim 1, wherein: X(1) and X(2) are 132embedded image T1 is zero or 2, R(A) and R(B) are, independently, hydrogen, F, Cl, CN, OR(106), (C1-C4)-alkyl, (C5-C6)-cycloalkyl, CF3 or NR(107)R(108), R(106) is hydrogen, (C1-C4)-alkyl, CF3, phenyl or benzyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(111)R(112), R(111) and R(112) being hydrogen, CH3 or CF3, R(107) and R(108) are, independently of each other, defined as R(106), or R(107) and R(108) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, or X(1) is 133embedded image where the double bond can be in the E or Z configuration, or X(1) is 134embedded image U, YY and Z are, independently of each other, C or N; with, however, the restriction that only one of the positions U, YY and Z can be nitrogen; where U, YY and Z can carry the following number of substituents: 10
U, YYBonded to a doubleNumber of permit-
or Zbond in the ringted substituents
Cyes1
Cno2
Nyes0
Nno1
R(D) is hydrogen, R(U1), R(U2), R(Y1), R(Y2), R(Z1) and R(Z2) are, independently of each other, hydrogen, F, Cl, CN, OR(114), CH3, CF3 or NR(115)R(116) R(114) is hydrogen, (C1-C4)-alkyl, CF3, phenyl or benzyl, where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119)R(120), R(119) and R(120) being hydrogen, CH3 or CF3, R(115) and R(116) are, independently of each other, defined as R(114), or R(115) and R(116) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, R(101) is hydrogen, F, Cl, CH3, OH, NH2 or CF3, R(102) is hydrogen, F, Cl, Br, —C≡N, —CzqaF2zqaCF3, R(110a)-SO2R(110b)R(110c)N—CO—, R(111a)-CO— or R(112a)R(113a)N—SO2—, R(110a), R(110b), R(111a) and R(112a) are, independently, (C1-C4)-alkyl, (C3-C4)-alkenyl, —CznH2zn—R(115a) or CF3, zn is zero or 1, zqa is zero, 1, 2, 3, 4 or 5, R(115a) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a), R(116a) and R(117a) being hydrogen or methyl, or R(110b), R(111a) and R(112a) are also hydrogen, R(110c) and R(113a) are, independently, hydrogen or methyl, R(103) is —Y-para-C6H4—(CO)zh—(CHOH)zi—(CH2)zj—(CHOH)zk—R(123), —Y-meta-C6H4—(CO)zad—(CHOH)zae—(CH2)zaf—(CHOH)zag—R(124) or —Y-ortho-C6H4—(CO)zah—(CHOH)zao—(CH2)zap—(CHOH)zak—R(125), Y is oxygen, S or —NR(83), R(123), R(124), R(125) and R(83) are, independently, hydrogen or methyl, zh, zad and zah are, independently, zero or 1, zi, zk, zae, zag, zao and zak are, independently, zero, 1, 2 or 3,3 zj, zaf and zap are, independently, zero or 1, where, however, in each case, zh, zi and zk are not simultaneously zero, zad, zae and zag are not simultaneously zero and zah, zao and zak are not simultaneously zero, or R(103) is hydrogen, F, Cl, Br, CN, (C1-C8)-alkyl, CF3, (C3-C8)-alkenyl or —CzalH2zalR(118a), zal is zero, 1 or 2, R(118a) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119a)R(119b), R(119a) and R(119b) being hydrogen or CH3, or R(103) is (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino, or R(103) is —W-para-(C6H4)—R(196), —W-meta-(C6H4)—R(197) or —W-ortho-(C6H4)—R(198), R(196), R(197) and R(198) are, independently, pyrrolyl, imidazolyl, pyrazolyl or pyridyl which in each case is unsubstituted or substituted by 1 to 2 radicals selected from the group consisting of F, Cl, CF3, CH3, methoxy, dimethylamino and benzyl, W is oxygen, —S— or NR(136)—, R(136) being hydrogen or methyl, or R(103) is —SR (129), —OR (130), —NR (131)R(132) or —CR(133)R(134)R(135), R(129), R(130), R(131) and R(133) are, independently of each other, —CzabH2zab—(C1-C9)-heteroaryl which is unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino, zab is zero or 1, R(132), R(134) and R(135) are, independently of each other, hydrogen or CH3, or R(103) is R(110a)-SO2 or R(112a)R(113a)N—SO2—, R(110a) is (C1-C4)-alkyl, CF3, (C3-C4)-alkenyl or —CznH2zn—R(115a), zn is zero or 1, R(115a) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a), R(116a) and R(117a) being hydrogen or CH3, R(112a) is hydrogen, (C1-C4)-alkyl, CF3, (C3-C4)-alkenyl or —CzaH2za—R(115a), za is zero or 1, R(115a) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a), R(116a) and R(117a) being hydrogen or CH3, R(113a) is hydrogen or CH3, or R(112a) and R(113a) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, or R(103) is R(146)X(1a)-, X(1a) is oxygen, S, NR(147), (C═O)A- or NR(148)C=MN(%)R(149)-, M is oxygen, and A is oxygen or NR(150), R(146) and R(147) are, independently, hydrogen, (C1-C6)-alkyl, (C3-C4)-alkenyl, (CH2)zbzCzdzF2zdz+1 or CzxaH2zxa—R(151), zbz is zero or 1, zdz is 1, 2, 3, 4, 5, 6 or 7, zxa is zero or 1, R(151) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy or NR(152)R(153), R(152) and R(153) being hydrogen or CH3, R(148) is hydrogen or (C1-C4)-alkyl, R(149) is defined as R(146), or 20 R(146) and R(147), or R(146) and R(148), respectively, are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, where A and N(*) are bonded to the phenyl nucleus of the benzoylguanidine parent substance, or R(103) is —SR(164), —OR(165), —NHR(166), —NR(167)R(168), —CHR(169)R(170), —[CR(154)R(155)OH], —C≡CR(156), —CR(158)=CR(157) or —[CR(159)R(160a)]zz-(CO)-[CR(161)R(162)]zv-R(163), R(164), R(165), R(166), R(167) and R(169) are identical or different and are —(CH2)zy—(CHOH)zz—(CH2)zaa—(CHOH)zt—R(171) or —(CH2)zab—O—(CH2—CH2O)zac—R(172), R(171) and R(172) are hydrogen or methyl, zu is 1 or 2, zv is zero, 1 or 2, zy, zz, zaa, zab and zac are identical or different and are zero, 1 or 2, zt is 1, 2 or 3, R(168), R(170), R(154) and R(155) are identical or different and are hydrogen or methyl, or R(169) and R(170), or R(154) and R(155), respectively, together with the carbon atom carrying them, are a (C3-C6)-cycloalkyl, R(163) is hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl or —CzebH2zeb—R(173), zeb is zero, 1 or 2, R(156), R(157) and R(173) are, independently of each other, phenyl which is unsubstituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(174)R(175), R(174) and R(175) being hydrogen or CH3, or R(156), R(157) and R(173) are, independently of each other, (C1-C9)-heteroaryl which is unsubstituted or is substituted as phenyl, R(158), R(159), R(160), R(161) and R(162) are hydrogen or methyl, or R(103) is R(176)-NH—SO2—, R(176) is R(177)R(178)N—(C═Y′)—, Y′ is oxygen, S or N—R(179), R(177) and R(178) are identical or different and are hydrogen, (C1-C4)-alkyl, (C3-C4)-alkenyl or —CzfaH2zfa—R(180), zfa is zero or 1, R(180) is (C5-C7)-cycloalkyl or phenyl which is unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methoxy or methyl, or R(177) and R(178) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, R(179) is defined as R(177), R(104) is hydrogen, CF3 (C1-C8)-alkyl or —CzalH2zalR(118a), zal is zero or 1, R(118a) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119a)R(119b), R(119a) and R(119b) being hydrogen or CH3, or R(104) is quinolyl, isoquinolyl, pyrrolyl, pyridyl or imidazolyl which are linked via C or N and which are unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino, or R(104) is R(110a)-SO2 or R(112a)R(113a)N—SO2—, R(110a) is (C1-C4)-alkyl or CF3, R(112a) is hydrogen, (C1-C4)-alkyl, CF3 or —CzaH2za—R(115a), za is zero or 1, R(115a) is phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a), R(116a) and R(117a) being hydrogen or CH3, R(113a) is hydrogen or CH3, or R(104) is —C≡CR(193), R(193) is phenyl which is unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(194)R(195), R(194) and R(195) being hydrogen or CH3, R(105) is hydrogen.

4. A process for preparing a compound I as claimed in claim 1, wherein a) two equivalents of the compounds of the formula II are reacted with one equivalent of the guanidine, 135embedded image where X(1) and X(2) have the given meaning and L is a leaving group which can readily be substituted nucleophilically, or b) a compound of the formula Ia 136embedded image is reacted with a compound of the formula III 137embedded image with the participation of a base, where X(1) and X(2) have the given meaning and L is a leaving group which can readily be substituted nucleophilically, and wherein conversion takes place, where appropriate, into a pharmaceutically tolerated salt.

5. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment of arrhythmias.

6. A method for treating arrhythmias, wherein an effective quantity of a compound I as claimed in claim 1 is treated with the customary additives and administered in a suitable form for administration.

7. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of cardiac infarction.

8. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of angina pectoris.

9. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of ischemic conditions of the heart.

10. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of ischemic conditions of the peripheral and central nervous system and of stroke.

11. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment or prophylaxis of ischemic conditions of peripheral organs and limbs.

12. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment of shock conditions.

13. The use of a compound I as claimed in claim 1 for preparing a medicament for employment in surgical operations and organ transplantations.

14. The use of a compound I as claimed in claim 1 for preparing a medicament for the preservation and storage of transplants for surgical procedures.

15. The use of a compound I as claimed in claim 1 for preparing a medicament for the treatment of diseases in which cell proliferation represents a primary or secondary cause, and consequently its use as an anti-atherosclerotic agent, or as an agent against diabetic late complications, cancerous diseases, fibrotic diseases such as pulmonary fibrosis, hepatic fibrosis or renal fibrosis, and against hyperplasia of the prostate.

16. The use of a compound I as claimed in claim 1 for preparing a scientific tool for inhibiting the Na+/H+ exchanger and for diagnosing hypertension and proliferative diseases.

17. A medicine containing an effective quantity of a compound I as claimed in claim 1.

Description:
[0001] Diacyl-substituted guanidines, a process for their preparation, their use as medicament or diagnostic aid, and medicament containing them.

[0002] The invention relates to diacyl-substituted guanidines of the formula I 5embedded image

[0003] in which:

[0004] X(1) and X(2) are 6embedded image

[0005] T1 is zero, 1, 2, 3 or 4,

[0006] R(A) and R(B) are, independently,

[0007] hydrogen, F, Cl, Br, I, CN, OR(106), (C1-C8)-alkyl, (C3-C8) -cycloalkyl, Ozk(CH2)zlCzmF2zm+1, NR(107)R(108), phenyl or benzyl,

[0008] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(109)R(110),

[0009] R(109) and R(110) being

[0010] hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0011] z1 is zero, 1, 2, 3 or 4,

[0012] zk is zero or 1,

[0013] zm is 1, 2, 3, 4, 5, 6, 7 or 8,

[0014] R(106) is

[0015] hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl, (C3-C8)-alkenyl, (C3-C8)-cycloalkyl, phenyl or benzyl,

[0016] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and

[0017] NR(111)R(112),

[0018] R(111) and R(112) being

[0019] hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0020] R(107) and R(108) are, independently of each other, defined as R(106),

[0021] or

[0022] R(107) and R(108) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0023] or

[0024] X(1) and X(2) are 7embedded image

[0025] T2a and T2b are, independently of each other, zero, 1 or 2,

[0026] where the double bond can have the E or Z configuration;

[0027] or

[0028] X(1) and X(2) are 8embedded image

[0029] T3 is zero, 1 or 2,

[0030] U, YY and Z are, independently of each other, C or N,

[0031] where U, YY and Z can carry the following number of substituents: 1

Bonded to a doubleNumber of permitted
U, YY or Zbond in the ringsubstituents
Cyes1
Cno2
Nyes0
Nno1

[0032] R(D) is hydrogen, (C1-C8)-alkyl or (C1-C8)-perfluoroalkyl, R(U1), R(U2), R(Y1), R(Y2), R(Z1) and R(Z2) are, independently of each other,

[0033] hydrogen, F, Cl, Br, I, CN, OR(114), (C1-C8)-alkyl, (C3-C8)-cycloalkyl, Ozka (CH2)zlaCzmaF2zma+1,

[0034] NR(115)R(116), phenyl or benzyl,

[0035] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(117)R(118),

[0036] R(117) and R(118) being hydrogen, (C1-C4)-alkyl

[0037] or (C1-C4) perfluoroalkyl,

[0038] zka is zero or 1,

[0039] zla is zero, 1, 2, 3 or 4,

[0040] zma is 1, 2, 3, 4, 5, 6, 7 or 8,

[0041] R(114) is hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl, (C3-C8)-alkenyl, (C3-C8)-cycloalkyl, phenyl or benzyl,

[0042] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119)R(120),

[0043] R(119) and R(120) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0044] R(115) and R(116) are, independently of each other, defined as R(114),

[0045] or

[0046] R(115) and R(116)

[0047] are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0048] where, however, the constitution U is nitrogen (N), YY is nitrogen (N) and Z is carbon (C) is excepted,

[0049] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0050] hydrogen, F, Cl, Br, I, —C≡N, Xzoa—(CH2)zpa—(CzqaF2zqa+1), R(110a)-SOzbm, R(110b)R(110c)N—CO, R(111a)-CO— or R(112a)R(113a)N—SO2—,

[0051] where the perfluoroalkyl group is straight-chain or branched,

[0052] X is hydrogen, S or NR(114a),

[0053] zoa is zero or 1,

[0054] R(114a) being H or (C1-C3)-alkyl,

[0055] zbm is zero, 1 or 2,

[0056] zpa is zero, 1, 2, 3 or 4,

[0057] zqa is 1, 2, 3, 4, 5, 6, 7 or 8,

[0058] R(110a), R(110b), R(111a) and R(112a) are, independently,

[0059] (C1-C8)-alkyl, (C3-C8)-alkenyl, —CznH2zn—R(115a) or (C1-C8)-perfluoroalkyl,

[0060] zn is zero, 1, 2, 3 or 4,

[0061] R(115a) is

[0062] (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0063] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a),

[0064] R(116a) and R(117a) being

[0065] hydrogen, (C1-C4)-perfluoroalkyl or (C1-C4)-alkyl,

[0066] or

[0067] R(110b), R(111a) and R(112a) are also hydrogen,

[0068] R(110c) and R(113a) are, independently,

[0069] hydrogen, (C1-C4)-perfluoroalkyl or (C1-C4)-alkyl,

[0070] or

[0071] R(110b) and R(110c) and also R(112a) and R(113a) are together 4 or 5 methylene groups, of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl,

[0072] or

[0073] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0074] (C1-C8)-alkyl, —CzaH2zalR(118a) or (C3-C8)-alkenyl,

[0075] zal is zero, 1, 2, 3 or 4,

[0076] R(118a) is

[0077] (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0078] where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(119a)R(119b),

[0079] R(119a) and R(119b) being

[0080] hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0081] or

[0082] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0083] (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino,

[0084] or

[0085] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0086] —C≡C—R(193),

[0087] R(193) is

[0088] phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(194)R(195),

[0089] R(194) and R(195) being

[0090] hydrogen or CH3,

[0091] or

[0092] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0093] —Y-para-C6H4—(CO)zh—(CHOH)zi—(CH2)zj—(CHOH)zk—R(123),

[0094] —Y-meta-C6H4—(CO)zad—(CHOH)zae—(CH2)zaf—(CHOH)zag—R(124)

[0095] or

[0096] —Y-ortho-C6H4—(CO)zah—(CHOH)zao—(CH2)zap—(CHOH)zak—R(125):

[0097] Y is oxygen, —S— or —NR(122d)-,

[0098] zh, zad and zah are, independently,

[0099] zero or 1,

[0100] zi, zj, zk, zae, zaf, zag, zao, zap and zak are, independently,

[0101] zero, 1, 2, 3 or 4,

[0102] where, however, in each case,

[0103] zh, zi and zk are not simultaneously zero,

[0104] zad, zae and zag are not simultaneously zero and

[0105] zah, zao and zak are not simultaneously zero,

[0106] R(123), R(124) R(125) and R(122d) are, independently, hydrogen or (C1-C3)-alkyl,

[0107] or

[0108] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0109] SR(129), —OR(130), —NR(131)R(132) or —CR(133)—R(134)R(135),

[0110] R(129), R(130), R(131) and R(133), are, independently,

[0111] —CzabH2zab—(C1-C9)-heteroaryl which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino,

[0112] zab is zero, 1 or 2,

[0113] R(132), R(134) and R(135) are, independently of each other,

[0114] defined as R(129), or hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0115] or

[0116] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0117] —W-para-(C6H4)—R(196), —W-meta-(C6H4)—R(197) or —W-ortho-(C6H4)—R(198),

[0118] R(196), R(197) and R(198) are, independently,

[0119] (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1 to 3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino, dimethylamino and benzyl,

[0120] W is oxygen, S or NR(136)-,

[0121] R(136) being hydrogen or (C1-C4)-alkyl,

[0122] or

[0123] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0124] R(146)X(1a)-,

[0125] X(1a) is oxygen, S, NR(147), (D=O)A- or

[0126] NR(148)C=MN(+)R(149)-,

[0127] M is oxygen or sulfur,

[0128] A is oxygen or NR(150), and

[0129] D is C or SO,

[0130] R(146) is (C1-C8)-alkyl, (C3-C8)-alkenyl,

[0131] (CH2)zbzCzdzF2zdz+1 or —CzxaH2zxa—R(151),

[0132] zbz is zero or 1,

[0133] zdz is 1, 2, 3, 4, 5, 6 or 7,

[0134] zxa is zero, 1, 2, 3 or 4,

[0135] R(151) is

[0136] (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0137] where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(152)R(153),

[0138] R(152) and R(153) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0139] R(147), R(148) and R(150) are, independently, hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0140] R(149) is defined as R(146),

[0141] or

[0142] R(146) and R(147), or R(146) and R(148), respectively, are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl, where A and N(+) are bonded to the phenyl nucleus of the alkanoyl parent substance,

[0143] or

[0144] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0145] —SR(164), —OR(165), —NHR(166), —NR(167)R(168), —CH R(169)R(170),

[0146] —CR(154)R(155)OH, —C≡CR(156), —CR(158)═CR(157) or —[(CR(159)R(160)zu-(C═O)—[CR(161)R(162)]zv-R(163),

[0147] R(164), R(165), R(166), R(167) and R(169) are identical or different and are

[0148] —(CH2)zy—(CHOH)zz—(CH2)zaa—(CHOH)zt—R(171) or —(CH2)zab—O—(CH2—CH2O)zac—R(172),

[0149] R(171) and R(172) being hydrogen or methyl,

[0150] zu is 1, 2, 3 or 4,

[0151] zv is zero, 1, 2, 3 or 4,

[0152] zy, zz, zaa, zab and zac are identical or different and are

[0153] zero, 1, 2, 3 or 4,

[0154] zt is 1, 2, 3 or 4,

[0155] R(168), R(170), R(154) and R(155) are identical or different and are

[0156] hydrogen or (C1-C6)-alkyl,

[0157] or

[0158] R(169) and R(170), or R(154) and R(155), respectively, are, together with the carbon atom carrying them, a (C3-C8)-cycloalkyl,

[0159] R(163)

[0160] is hydrogen, (C1-C6)-alkyl, (C3-C8)-cycloalkyl or —CzebH2zeb—R(173),

[0161] zeb is zero, 1, 2, 3 or 4,

[0162] R(156), R(157) and R(173) are, independently, phenyl which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and

[0163] NR(174)R(175),

[0164] R(174) and R(175) being hydrogen or (C1-C4)-alkyl,

[0165] or

[0166] R(156), R(157) and R(173) are, independently,

[0167] (C1-C9)-heteroaryl which is unsubstituted or is substituted as phenyl,

[0168] R(158), R(159), R(160), R(161) and R(162) are hydrogen or methyl,

[0169] or

[0170] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0171] R(176)-NH—SO2—,

[0172] R(176) is R(177)R(178)N—(C═Y′)—,

[0173] Y′ is oxygen, S or N—R(179),

[0174] R(177) and R(178) are identical or different and are

[0175] hydrogen, (C1-C8)-alkyl, (C3-C6)-alkenyl or —CzfaH2zfa—R(180)

[0176] zfa is zero, 1, 2, 3 or 4,

[0177] R(180) is (C5-C7)-cycloalkyl or phenyl which is unsubstituted or substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methoxy or (C1-C4)-alkyl,

[0178] or

[0179] R(177) and R(178)

[0180] are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl,

[0181] R(179) is defined as R(177) or is amidine,

[0182] or

[0183] R(101), R(102), R(103), R(104) and R(105) are, independently of each other,

[0184] NR(184a)R(185), OR(184b), SR(184c) or —CznxH2znx—R(184d)

[0185] znx is zero, 1, 2, 3 or 4,

[0186] R(184d)

[0187] is (C3-C7)-cycloalkyl or phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116k)R(117k),

[0188] R(116k) and R(117k) being hydrogen or (C1-C4)-alkyl,

[0189] R(184a), R(184b), R(184c) and R(185) are, independently of each other,

[0190] hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl or (CH2)zao—R(184g),

[0191] zao is zero, 1, 2, 3 or 4,

[0192] 184g is (C3-C7)-cycloalkyl or phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(184u)R(184v),

[0193] R(184u) and R(184v) being hydrogen or (C1-C4)-alkyl,

[0194] or

[0195] R(184a) and R(185) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, sulfur, NH, N—CH3 or N-benzyl,

[0196] and also pharmaceutically tolerated salts thereof,

[0197] where, however, the following compounds are excepted: 9embedded image

[0198] and

[0199] where, additionally, the compounds are excepted in which the radicals R(1) to R(5) are combined as follows: 2

R(101)R(102)R(103)R(104)R(105)R(105)R(104)R(103)R(102)R(101)
[X(1)][X(1)][X(1)][X(1)][X(1)][X(2)][X(2)][X(2)][X(2)][X(2)]
HClClHHHHClClH
HHNH2HHHHNH2HH
HHHHHHHHHH
ClHHHHHHHHCl
HHClHHHHClHH
HHCH3HHHHCH3HH
HHNH2HHHHHHH
HHClHHHHHHH
HHCH3HHHHHHH

[0200] Compounds of the formula I are preferred in which X(1) is the same as X(2) and in which the other substituents are as defined above.

[0201] Compounds of the formula I are particularly preferred in which:

[0202] X(1) and X(2) are 10embedded image

[0203] T1 is zero or 2,

[0204] R(A) and R(B) are, independently,

[0205] hydrogen, F, Cl, CN, OR(106), (C1-C4)-alkyl, (C1-C6)-cycloalkyl, CF3 or NR(107)R(108),

[0206] R(106)

[0207] is hydrogen, (C1-C4)-alkyl, CF3, phenyl or benzyl,

[0208] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(111)R(112),

[0209] R(111) and R(112) being hydrogen, CH3 or CF3,

[0210] R(107) and R(108) are, independently of each other, defined as R(106),

[0211] or

[0212] R(107) and R(108) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0213] or

[0214] X(1) is 11embedded image

[0215] where the double bond can be in the E or Z configuration,

[0216] or

[0217] X(1) is 12embedded image

[0218] U, YY and Z are, independently of each other, C or N;

[0219] with, however, the restriction that only one of the positions U, YY and Z can be nitrogen;

[0220] where

[0221] U, YY and Z can carry the following number of substituents: 3

U, YYBonded to a doubleNumber of permit-
or Zbond in the ringted substituents
Cyes1
Cno2
Nyes0
Nno1

[0222] R(D) is hydrogen,

[0223] R(U1), R(U2), R(Y1), R(Y2), R(Z1) and R(Z2) are, independently of each other,

[0224] hydrogen, F, Cl, CN, OR(114), CH3, CF3 or NR(115)R(116)

[0225] R(114)

[0226] is hydrogen, (C1-C4)-alkyl, CF3, phenyl or benzyl,

[0227] where the aromatic radicals are not substituted or are substituted by 1-3 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119)R(120),

[0228] R(119) and R(120) being hydrogen, CH3 or CF3,

[0229] R(115) and R(116) are, independently of each other, defined as R(114),

[0230] or

[0231] R(115) and R(116)

[0232] are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0233] R(101)

[0234] is hydrogen, F, Cl, CH3, OH, NH2 or CF3,

[0235] R(102)

[0236] is hydrogen, F, Cl, Br, —C≡N, —CzqaF2zqaCF3, R(110a)-SO2, R(110b)R(110c)N—CO—, R(111a)-CO— or R(112a)R(113a)N—SO2—,

[0237] R(110a), R(110b), R(111a) and R(112a) are, independently,

[0238] (C1-C4)-alkyl, (C3-C4)-alkenyl, —CznH2zn—R(115a)

[0239] or CF3,

[0240] zn is zero or 1,

[0241] zqa is zero, 1, 2, 3, 4 or 5,

[0242] R(115a)

[0243] is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a),

[0244] R(116a) and R(117a) being hydrogen or methyl,

[0245] or

[0246] R(110b), R(111a) and R(112a) are also hydrogen,

[0247] R(110c) and R(113a) are, independently, hydrogen or methyl,

[0248] R(103)

[0249] is —Y-para-C6H4—(CO)zh—(CHOH)zi—(CH2)zj—(CHOH)zk—R(123),

[0250] —Y-meta-C6H4—(CO)zad—(CHOH)zae—(CH2)zaf—(CHOH)zag—R(124) or

[0251] —Y-ortho-C6H4—(CO)zah—(CHOH)zao—(CH2)zap—(CHOH)zak—R(125),

[0252] Y is oxygen, S or —NR(83),

[0253] R(123), R(124), R(125) and R(83) are, independently, hydrogen or methyl,

[0254] zh, zad and zah are, independently,

[0255] zero or 1,

[0256] zi, zk, zae, zag, zao and zak are, independently,

[0257] zero, 1, 2 or 3,

[0258] zj, zaf and zap are, independently,

[0259] zero or 1,

[0260] where, however, in each case, zh, zi and zk are not simultaneously zero,

[0261] zad, zae and zag are not simultaneously zero and

[0262] zah, zao and zak are not simultaneously zero,

[0263] or

[0264] R(103) is hydrogen, F, Cl, Br, CN, (C1-C8)-alkyl, CF3, (C3-C8)-alkenyl or —CzalH2zalR(118a),

[0265] zal is zero, 1 or 2,

[0266] R(118a) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and

[0267] NR(119a)R(119b),

[0268] R(119a) and R(119b) being hydrogen or CH3,

[0269] or

[0270] R(103)

[0271] is (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino,

[0272] or

[0273] R(103)

[0274] is —W-para-(C6H4)—R(196), —W-meta-(C6H4)—R(197) or —W-ortho-(C6H4)—R(198),

[0275] R(197) and R(198) are, independently, pyrrolyl, imidazolyl, pyrazolyl or pyridyl which in each case is unsubstituted or substituted by 1 to 2 radicals selected from the group consisting of F, Cl, CF3, CH3, methoxy, dimethylamino and benzyl,

[0276] W is oxygen, —S— or NR(136)-,

[0277] R(136) being hydrogen or methyl,

[0278] or

[0279] R(103) is

[0280] —SR(129), —OR(130), —NR(131)R(132) or —CR(133)R(134)R(135),

[0281] R(129), R(130), R(131) and R(133) are, independently of each other,

[0282] —CzabH2zab—(C1-C9)-heteroaryl which is unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino,

[0283] zab is zero or 1,

[0284] R(132), R(134) and R(135) are, independently of each other,

[0285] hydrogen or CH3,

[0286] or

[0287] R(103) is

[0288] R(110a)-SO2 or R(112a)R(113a)N—SO2—,

[0289] R(110a) is

[0290] (C1-C4)-alkyl, CF3, (C3-C4)-alkenyl or —CznH2zn—R(115a),

[0291] zn is zero or 1,

[0292] R(115a) is

[0293] (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and

[0294] NR(116a)R(117a),

[0295] R(116a) and R(117a) being hydrogen or CH3,

[0296] R(112a) is

[0297] hydrogen, (C1-C4)-alkyl, CF3, (C3-C4)-alkenyl or —CzaH2za—R(115a),

[0298] za is zero or 1,

[0299] R(115a) is

[0300] (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and

[0301] NR(116a)R(117a),

[0302] R(116a) and R(117a) being hydrogen or CH3,

[0303] R(113a) is

[0304] hydrogen or CH3,

[0305] or

[0306] R(112a) and R(113a) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0307] or

[0308] R(103) is

[0309] R(146)X(1a)-,

[0310] X(1a) is oxygen, S, NR(147), (C═O)A- or

[0311] NR(148)C=MN(*)R(149)-,

[0312] M is oxygen, and

[0313] A is oxygen or NR(150),

[0314] R(146) and R(147) are, independently,

[0315] hydrogen, (C1-C6)-alkyl, (C3-C4)-alkenyl,

[0316] (CH2)zbzCzdzF2zdz+1 or CzxaH2zxa—R(151)

[0317] zbz is zero or 1,

[0318] zdz is 1, 2, 3, 4, 5, 6 or 7,

[0319] zxa is zero or 1,

[0320] R(151)

[0321] is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy or NR(152)R(153),

[0322] R(152) and R(153) being hydrogen or CH3,

[0323] R(148)

[0324] is hydrogen or (C1-C4)-alkyl,

[0325] R(149) is defined as R(146),

[0326] or

[0327] R(146) and R(147), or R(146) and R(148), respectively, are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0328] where A and N(*) are bonded to the phenyl nucleus of the benzoylguanidine parent substance,

[0329] or

[0330] R(103)

[0331] is —SR(164), —OR(165), —NHR(166), —NR(167)R(168), —CHR(169)R(170), —[CR(154)R(155)OH], —C≡CR(156), —CR(158)=CR(157) or

[0332] —[CR(159)R(160a)]zu-(CO)—[CR(161)R(162)]zv-R(163),

[0333] R(164), R(165), R(166), R(167) and R(169) are identical or different and are

[0334] —(CH2)zy—(CHOH)zz—(CH2)zaa—(CHOH)zt—R(171) or

[0335] —(CH2)zab—O—(CH2—CH2O)zac—R(172),

[0336] R(171) and R(172) are hydrogen or methyl,

[0337] zu is 1 or 2,

[0338] zv is zero, 1 or 2,

[0339] zy, zz, zaa, zab and zac are identical or different and are

[0340] zero, 1 or 2,

[0341] zt is 1, 2 or 3,

[0342] R(168), R(170), R(154) and R(155) are identical or different and are

[0343] hydrogen or methyl,

[0344] or

[0345] R(169) and R(170), or R(154) and R(155), respectively, together with the carbon atom carrying them, are a (C3-C6)-cycloalkyl,

[0346] R(163) is

[0347] hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl or

[0348] CzebH2zeb—R(173)

[0349] zeb is zero, 1 or 2,

[0350] R(156), R(157) and R(173) are, independently of each other,

[0351] phenyl which is unsubstituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and

[0352] NR(174)R(175),

[0353] R(174) and R(175) being hydrogen or CH3,

[0354] or

[0355] R(156), R(157) and R(173) are, independently of each other,

[0356] (C1-C9)-heteroaryl which is unsubstituted or is substituted as phenyl,

[0357] R(15B), R(159), R(160), R(161) and R(162) are hydrogen or methyl,

[0358] or

[0359] R(103)

[0360] is R(176)-NH—SO2—,

[0361] R(176)

[0362] is R(177)R(178)N—(C═Y′)—,

[0363] Y, is oxygen, S or N—R(179),

[0364] R(177) and R(178) are identical or different and are hydrogen, (C1-C4)-alkyl, (C3-C4)-alkenyl or —CzfaH2zfa—R(180),

[0365] zfa is zero or 1,

[0366] R(180)

[0367] is (C1-C7)-cycloalkyl or phenyl which is unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methoxy or methyl,

[0368] or

[0369] R(177) and R(178) are together 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0370] R(179) is defined as R(177),

[0371] R(104)

[0372] is hydrogen, CF3 (C1-C8)-alkyl or —CzalH2zalR(118a)

[0373] zal is zero or 1,

[0374] R(118a)

[0375] is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(119a)R(119b),

[0376] R(119a) and R(119b) being hydrogen or CH3,

[0377] or

[0378] R(104)

[0379] is quinolyl, isoquinolyl, pyrrolyl, pyridyl or imidazolyl which are linked via C or N and which are unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino and dimethylamino,

[0380] or

[0381] R(104)

[0382] is R(110a)-SO2 or R(112a)R(113a)N—SO2—,

[0383] R(110a)

[0384] is (C1-C4)-alkyl or CF3,

[0385] R(112a)

[0386] is hydrogen, (C1-C4)-alkyl, CF3 or CzaH2za—R(115a),

[0387] za is zero or 1,

[0388] R(115a)

[0389] is phenyl which is not substituted or is substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(116a)R(117a),

[0390] R(116a) and R(117a) being hydrogen or CH3,

[0391] R(113a)

[0392] is hydrogen or CH3,

[0393] or

[0394] R(104)

[0395] is —C≡CR(193),

[0396] R(193)

[0397] is phenyl which is unsubstituted or substituted by 1-2 substituents selected from the group consisting of F, Cl, CF3, methyl, methoxy and NR(194)R(195),

[0398] R(194) and R(195) being hydrogen or CH3,

[0399] R(105)

[0400] is hydrogen,

[0401] and also the pharmaceutically tolerated salts thereof.

[0402] Dibenzoylguanidines of the formula Ia

[0403] are likewise preferred

[0404] in which:

[0405] R(1), R(5), R(6) and R(10) are, independently of each other, 13embedded image

[0406] hydrogen, F, Cl, (C1-C3)-alkyl, —OR(11), CrF2r+1 or

[0407] —NR(11)R(12),

[0408] R(11) and R(12) are, independently, hydrogen or (C1-C3)-alkyl,

[0409] r is from 1 to 4,

[0410] R(2), R(4), R(7) and R(9) are, independently of each other,

[0411] hydrogen, F, Cl, Br, I, —C≡N, Xo—(CH2)p—(CF2)q—CF3, R(13)-SOm, R(14)R(15)N—CO—, R(16)-CO— or

[0412] R(17)R(18)N—SO2—,

[0413] X is oxygen, S or NR(19),

[0414] m is zero, 1 or 2,

[0415] o is zero or 1,

[0416] p is zero, 1 or 2,

[0417] q is zero, 1, 2, 3, 4, 5 or 6,

[0418] R(13), R(14), R(16) and R(17) are, independently,

[0419] (C1-C8)-alkyl, (C3-C6)-alkenyl, —CnH2n—R(20) or CF3,

[0420] n is zero, 1, 2, 3 or 4,

[0421] R(19) is hydrogen or (C1-C3)-alkyl,

[0422] R(20) is (C3-C7)-cycloalkyl or phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(21)R(22) with R(21) and R(22) being H or (C1-C4)-alkyl,

[0423] where R(14), R(16) and R(17) also have the meaning of H,

[0424] R(15) and R(18) are, independently, hydrogen or (C1-C4)-alkyl,

[0425] where R(14) and R(15) and also R(17) and R(18) can together be 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0426] or

[0427] R(2), R(4), R(7) and R(9) are, independently of each other,

[0428] (C1-C8)-alkyl or —CalH2alR(84),

[0429] al is zero, 1 or 2,

[0430] R(84) is (C3-C8)-cycloalkyl or phenyl which is not substituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(85)R(86), with R(85) and R(86) being hydrogen or CH3; or

[0431] R(2), R(4), R(7) and R(9) are, independently of each other,

[0432] (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino or dimethylamino; or

[0433] R(2), R(4), R(7) and R(9) are, independently of each other,

[0434] —C≡CR(93),

[0435] R(93) is phenyl which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(94)R(95), with R(94) and R(95) being hydrogen or CH3;

[0436] R(3) and R(8) are, independently of each other, defined as R(2), or are 14embedded image

[0437] Y is oxygen, —S— or —NR(83)-,

[0438] h, ad and ah are, independently, zero or 1,

[0439] i, j, k, ae, af, ag, ao, ap and ak are, independently,

[0440] zero, 1, 2, 3 or 4,

[0441] where, however, in each case, h, i and k are not simultaneously zero,

[0442] ad, ae and ag are not simultaneously zero and

[0443] ah, ao and ak are not simultaneously zero,

[0444] R(23), R(24), R(25) and R(83) are, independently, hydrogen or (C1-C3)-alkyl,

[0445] or

[0446] R(3) and R(8) are, independently of each other, hydrogen, F, Cl, Br, I, CN, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl, (C3-C8)-alkenyl or —CgH2gR(26),

[0447] g is zero, 1, 2, 3 or 4,

[0448] R(26) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0449] where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or

[0450] NR(27)R(28), with R(27) and R(28) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl; or

[0451] R(3) and R(8) are, independently of each other,

[0452] SR(29), —OR(30), —NR(31)R(32) or —CR(33)R(34)R(35);

[0453] R(29), R(30), R(31) and R(33) are, independently,

[0454] —CaH2a—(C1-C9)-heteroaryl which is unsubstituted or substituted by 1-3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino or dimethylamino,

[0455] a is zero, 1 or 2,

[0456] R(32), R(34) and R(35) are, independently of each other,

[0457] defined as R(29), or hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl; or

[0458] R(3) and R(8) are, independently of each other, 15embedded image

[0459] R(96), R(97) and R(98) are, independently,

[0460] (C1-C9)-heteroaryl which is linked via C or N and which is unsubstituted or is substituted by 1 to 3 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino, dimethylamino or benzyl,

[0461] W is oxygen, S or NR(99)-,

[0462] R(99) is hydrogen or (C1-C4)-alkyl,

[0463] or

[0464] R(3) and R(8) are, independently of each other,

[0465] R(72)-SOm or R(73)R(74)N—SO2—,

[0466] m is 1 or 2,

[0467] R(72) is (C1-C9)-alkyl, (C1-C8)-perfluoroalkyl,

[0468] (C3-C8)-alkenyl or —CsH2s—R(75),

[0469] s is zero, 1, 2, 3 or 4,

[0470] R(75) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0471] where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(76)R(77), with R(76) and R(77) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl;

[0472] R(73) is hydrogen, (C1-C8)-alkyl, (C1-C8)-perfluoroalkyl, (C3-C8)-alkenyl or

[0473] —CwH2w—R(78),

[0474] w is zero, 1, 2, 3 or 4,

[0475] R(78) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0476] where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(79)R(80), with R(79) and R(80) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0477] R(74) is hydrogen, (C3-C4)-alkyl or (C3-C4)-perfluoroalkyl,

[0478] where R(73) and R(74) can together be 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl; or

[0479] R(3) and R(8) are, independently of each other,

[0480] R(39)X—,

[0481] X is oxygen, SI NR(40), (D=O)A- or

[0482] NR(41)C=MN(*)R(42)-, with

[0483] M is oxygen or S,

[0484] A is oxygen or NR(43), and

[0485] D is C or SO,

[0486] R(39) is (C1-C8)-alkyl, (C3-C8)-alkenyl,

[0487] (CH2)bCdF2d+1 or —CxH2x—R(44),

[0488] b is zero or 1,

[0489] d is 1, 2, 3, 4, 5, 6 or 7,

[0490] x is zero, 1, 2, 3 or 4,

[0491] R(44) is (C3-C8)-cycloalkyl, phenyl, biphenylyl or naphthyl,

[0492] where the aromatic radicals are not substituted or are substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(45)R(46); with R(45) and R(46) being hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl;

[0493] R(40), R(41) and R(43) are, independently,

[0494] hydrogen, (C1-C4)-alkyl or (C1-C4)-perfluoroalkyl,

[0495] R(42) is defined as R(39), where

[0496] R(39) and R(40), or R(39) and R(41), respectively, can together be 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, where

[0497] A and N(*) are bonded to the phenyl nucleus of the benzoylguanidine parent substance; or

[0498] R(3) and R(8) are, independently of each other,

[0499] —SR(47), —OR(48), —NHR(49), —NR(50)R(51), —CHR(52)R(53), 16embedded image

[0500] R(47), R(48), R(49), R(50) and R(52) are identical or different and are

[0501] —(CH2)y—(CHOH)z—(CH2)aa—(CH2OH)t—R(64) or (CH2)ab—O—(CH2—CH2O)ac—R(65),

[0502] R(64) and R(65) are hydrogen or methyl,

[0503] u=1, 2, 3 or 4,

[0504] v=zero, 1, 2, 3 or 4,

[0505] y, z and aa are identical or different and are zero, 1, 2, 3 or 4,

[0506] t=1, 2, 3 or 4,

[0507] R(51), R(53), R(54) and R(55) are identical or different and

[0508] are hydrogen or (C1-C6)-alkyl, or

[0509] R(52) and R(53), or R(54) and R(55), respectively, are, together with the carbon atom carrying them, a (C3-C8)-cycloalkyl;

[0510] R(63) is hydrogen, (C1-C6)-alkyl, (C3-C8)-cycloalkyl or —CeH2e—R(81),

[0511] e is zero, 1, 2, 3 or 4,

[0512] R(56), R(57) and R(81) are, independently, phenyl which is unsubstituted or is substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(82)R(66) with R(82) and R(66) being H or (C1-C4)-alkyl, or

[0513] R(56), R(57) and R(81) are, independently,

[0514] (C1-C9)-heteroaryl which is unsubstituted or is substituted as phenyl;

[0515] R(58), R(59), R(60), R(61) and R(62) are hydrogen or methyl, or

[0516] R(3) and R(8) are, independently of each other,

[0517] R(67)-NH—SO2—,

[0518] R(67) is R(68)R(69)N—(C≡Y′)—,

[0519] Y′ is oxygen, S or N—R(70),

[0520] R(68) and R(69) are identical or different and

[0521] are hydrogen, (C1-C8)-alkyl, (C3-C6)-alkenyl or —CfH2f—R(71),

[0522] f is zero, 1, 2, 3 or 4,

[0523] R(71) is (C5-C7)-cycloalkyl or phenyl which is unsubstituted or substituted by 1-3 substituents from the group consisting of F, Cl, CF3, methoxy or (C1-C4)-alkyl, or

[0524] R(68) and R(69) together form 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl, where R(70) is defined as R(68) or is amidine;

[0525] and also the pharmaceutically tolerated salts thereof,

[0526] where, however, compounds are excepted in which the radicals R(1) to R(10) are combined as follows: 4

R(1)R(2)R(3)R(4)R(5)R(6)R(7)R(8)R(9)R(10)
HClClHHHHClClH
HHNH2HHHHNH2HH
HHHHHHHHHH
ClHHHHHHHHCl
HHClHHHHClHH
HHCH3HHHHCH3HH
HHNH2HHHHHHH
HHClHHHHHHH
HHCH3HHHHHHH

[0527] Compounds of the formula Ia are likewise particularly preferred in which:

[0528] R(5)=R(6)=hydrogen,

[0529] the remaining residues are defined as above, and

[0530] R(1)=R(10)

[0531] R(2)=R(9)

[0532] R(3)=R(8)

[0533] R(4)=R(7).

[0534] Compounds of the formula Ia are likewise very particularly preferred in which:

[0535] R(1)=R(10)

[0536] =hydrogen, F, Cl, CH3, OH, NH2 and CF3,

[0537] R(2)=R(9)

[0538] =hydrogen, F, Cl, Br, —C≡N, —CqF2qCF3, R(13)-SO2,

[0539] R(14)R(15)N—CO—, R(16)-CO— or R(17)R(18)N—SO2—,

[0540] R(13), R(14), R(16) and R(17) are, independently,

[0541] (C1-C8)-alkyl, (C3-C4)-alkenyl, —CnH2n—R(20) or CF3,

[0542] n is zero or 1,

[0543] q is zero, 1, 2, 3, 4 or 5,

[0544] R(20) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(21)R(22),

[0545] R(21) and R(22) being hydrogen or methyl,

[0546] where R(14), R(16) and R(17) also have the meaning of hydrogen,

[0547] R(15) and R(18) are, independently, hydrogen or methyl,

[0548] R(3) and R(8) are, independently of each other, 17embedded image

[0549] Y is oxygen, S or —NR(83),

[0550] R(23), R(24), R(25) and R(83) are, independently,

[0551] hydrogen or methyl,

[0552] h, ad and ah are, independently,

[0553] zero or 1,

[0554] i, k, ae, ag, ao and ak are, independently,

[0555] zero, 1, 2 or 3,

[0556] j, af and ap are, independently,

[0557] zero or 1,

[0558] where, however, in each case, h, i and k are not simultaneously zero,

[0559] ad, ae and ag are not simultaneously zero and

[0560] ah, ao and ak are not simultaneously zero,

[0561] or

[0562] R(3)=R(8)

[0563] =hydrogen, F, Cl, Br, CN, (C1-C8)-alkyl, CF3, (C3-C8)-alkenyl or —CgH2gR(26)

[0564] g is zero, 1 or 2,

[0565] R(26) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(27)R(28), with R(27) and R(28) being H or CH3;

[0566] or

[0567] R(3)=R(8)

[0568] =(C1-C9)-heteroaryl, which is linked via C or N and which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino or dimethylamino;

[0569] or

[0570] R(3) and R(8) are, independently of each other, 18embedded image

[0571] R(96), R(97) and R(98) are, independently, pyrrolyl, imidazolyl, pyrazolyl or pyridyl which in each case is unsubstituted or substituted by 1 to 2 radicals from the group consisting of

[0572] F, Cl, CF3, CH3, methoxy, dimethylamino or benzyl,

[0573] W is oxygen, —S— or NR(99)-,

[0574] R(99) being hydrogen or methyl,

[0575] or

[0576] R(3)=R(8)

[0577] =—SR(29), —OR(30), —NR(31) R(32) or

[0578] —CR(33)R(34)R(35),

[0579] R(29), R(30), R(31) and R(33) are, independently of each other,

[0580] —CaH2a—(C1-C9)-heteroaryl which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino or dimethylamino,

[0581] a is zero or 1,

[0582] R(32), R(34) and R(35) are, independently of each other,

[0583] hydrogen or CH3;

[0584] or

[0585] R(3)=R(8)

[0586] =R(72)-SO2 or R(73)R(74)N—SO2—,

[0587] R(72) is (C1-C4)-alkyl, CF3, (C3-C4)-alkenyl or —CsH2s—R(75),

[0588] s is zero or 1,

[0589] R(75) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(76)R(77); with

[0590] R(76) and R(77) being hydrogen or CH3,

[0591] R(73) is hydrogen, (C1-C4)-alkyl, CF3, (C3-C4)-alkenyl or

[0592] —CwH2w—R(78),

[0593] w is zero or 1,

[0594] R(78) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or

[0595] NR(79)R(80), with R(79) and

[0596] R(80) being hydrogen or CH3,

[0597] R(74) is hydrogen or CH3,

[0598] where R(73) and R(74) can together be 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl;

[0599] or

[0600] R(3)=R(8)

[0601] =R(39)X—,

[0602] X is oxygen, S, NR(40), (C═O)A-, NR(41)C=MN(*)R—(42)-,

[0603] M is oxygen, and

[0604] A is oxygen or NR(43),

[0605] R(39) is (C1-C6)-alkyl, (C3-C4)-alkenyl,

[0606] (CH2)bCdF2d+1 or —CxH2x—R(44),

[0607] b is zero or 1,

[0608] d is 1-7,

[0609] x is zero or 1,

[0610] R(44) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or

[0611] NR(45)R(46), with R(45) and

[0612] R(46) being hydrogen or CH3,

[0613] R(41) is hydrogen or (C1-C4)-alkyl,

[0614] R(42) is defined as R(39), where

[0615] R(39) and R(40), or R(39) and R(41), respectively, can together be 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0616] where A and N(*) are bonded to the phenyl nucleus of the benzoylguanidine parent substance;

[0617] or

[0618] R(3) and R(8) are

[0619] —SR(47), —OR(48), —NHR(49), —NR(50)R(51), —CHR(52)R(53), 19embedded image

[0620] R(47), R(48), R(49), R(50) and R(52) are identical or different and are

[0621] —(CH2)y—(CHOH)x—(CH2)aa—(CH2OH)t—R(64) or

[0622] —(CH2)ab—O—(CH2—CH2O)ac—R(65),

[0623] with R(64) and R(65) being hydrogen or methyl,

[0624] u is 1 or 2,

[0625] v is zero, 1 or 2,

[0626] y, z, aa, ab and ac are identical or different and are zero, 1 or 2,

[0627] t is 1, 2 or 3,

[0628] R(51), R(53), R(54) and R(55) are identical or different and are

[0629] hydrogen or methyl, or

[0630] R(52) and R(53), or R(54) and R(55), respectively, are, together with the carbon atom carrying them, a (C3-C6)-cycloalkyl,

[0631] R(63) is hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl or —CeH2e—R(81),

[0632] e is zero, 1 or 2,

[0633] is R(56), R(57) and R(81) are, independently of each other,

[0634] phenyl which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(65)R(66) with R(65) and R(66) being hydrogen or CH3; or

[0635] R(56), R(57) and R(81) are, independently of each other,

[0636] (C1-C9)-heteroaryl which is unsubstituted or is substituted as phenyl;

[0637] R(58), R(59), R(60), R(61) and R(62) are hydrogen or methyl,

[0638] or

[0639] R(3) and R(8) are

[0640] R(67)-NH—SO2—,

[0641] R(67) is R(68)R(69)N—(C≡Y′)—,

[0642] Y′ is oxygen, S or N—R(70),

[0643] R(68) and R(69) are identical or different and are

[0644] hydrogen, (C1-C4)-alkyl, (C3-C4)-alkenyl or —CfH2f—R(71),

[0645] f is zero or 1,

[0646] R(71) is (C5-C7)-cycloalkyl or phenyl which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methoxy or methyl, or

[0647] R(68) and R(69) together form 4 or 5 methylene groups of which one CH2 group can be replaced by oxygen, S, NH, N—CH3 or N-benzyl,

[0648] R(70) is defined as R(68);

[0649] R(4)=R(7)

[0650] =(C1-C8)-alkyl, —CalH2alR(84) or CF3,

[0651] al is zero or 1,

[0652] R(84) is (C3-C6)-cycloalkyl or phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(85)R(86), with R(85) and R(86) being hydrogen or CH3,

[0653] or

[0654] R(4)=R(7)

[0655] =quinolyl, isoquinolyl, pyrrolyl, pyridyl or imidazolyl which are linked via C or N and which are unsubstituted or are substituted by 1-2 substituents from the group consisting of F, Cl, CF3, CH3, methoxy, hydroxyl, amino, methylamino or dimethylamino,

[0656] or

[0657] R(4)=R(7)

[0658] =R(87)-SOam or R(88)R(89)N—SO2—,

[0659] am is 2,

[0660] R(87) is (C1-C4)-alkyl or CF3.

[0661] R(88) is hydrogen, (C1-C4)-alkyl, CF3 or —CanH2an

[0662] R(90),

[0663] an is zero or 1,

[0664] R(90) is phenyl which is not substituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(90)R(91), with

[0665] R(90) and R(91) being hydrogen or CH3,

[0666] R(89) is hydrogen or CH3,

[0667] or

[0668] R(4)=R(7)

[0669] =—C≡CR(93),

[0670] R(93) is phenyl which is unsubstituted or is substituted by 1-2 substituents from the group consisting of F, Cl, CF3, methyl, methoxy or NR(94)R(95) with

[0671] R(94) and R(95) being hydrogen or CH3;

[0672] R(5)=R(6)

[0673] =hydrogen,

[0674] and also the pharmaceutically acceptable salts thereof.

[0675] (C1-C9)-Heteroaryl is, in particular, understood to mean radicals which are derived from phenyl or naphthyl and in which one or more CH groups are replaced by N, and/or in which at least two adjacent CH groups are replaced by S, NH or O (with the formation of a five-membered aromatic ring). In addition, one or both atoms of the condensation site of bicyclic radicals can also be N atoms (as in indolizinyl).

[0676] Heteroaryl is considered, in particular, to be furanyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, indazolyl, quinolyl, isoquinolyl, phthalazinyl, quinoxalinyl, quinazolinyl and cinnolinyl.

[0677] Should one of the substituents R(1) to R(198) contain one or more centers of asymmetry, these centers can then be in either the S or the R configuration. The compounds can be present as optical isomers, as diastereomers, as racemates, or as mixtures thereof.

[0678] The designated alkyl and perfluoroalkyl radicals can be present either in the straight-chain or the branched form.

[0679] The invention relates furthermore to a process for preparing the compounds I, wherein either two equivalents of the compounds of the formula II are reacted with one equivalent of guanidine 20embedded image

[0680] where X(1) and X(2) have the given meaning and L is a leaving group which can readily be substituted nucleophilically, or a compound of the formula IIa 21embedded image

[0681] is reacted with a compound of the formula III 22embedded image

[0682] with the participation of a base, for example K2CO3, NaOH or triethylamine, where X(1) and X(2) have the given meaning and L is a leaving group which can readily be substituted nucleophilically.

[0683] The activated acid derivatives of the formula II, in which L is an alkoxy, preferably a methoxy, group, a phenoxy group, a phenylthio, methylthio or 2-pyridylthio group, or a nitrogen heterocycle, preferably 1-imidazolyl, are advantageously obtained, in a manner known per se, from the underlying carbonyl chlorides (formula II, L=Cl), which, for their part, can be prepared, once again in a manner known per se, from the underlying carboxylic acids (formula II, L=OH), for example using thionyl chloride.

[0684] In addition to the carbonyl chlorides of the formula II (L=Cl), other activated acid derivatives of the formula II can also be prepared, in a manner known per se, directly from the underlying benzoic acid derivatives (formula II, L=OH) as can, for example, the methyl esters of the formula II with L=OCH3 by treatment with gaseous HCl in methanol, the imidazolides of the formula II by treatment with carbonyldiimidazole (L=1-imidazolyl, Staab, Angew. Chem. Int. Ed. Engl. 1, 351-367 (1962)], the mixed anhydrides II with Cl—COOC2H5 or tosyl chloride in the presence of triethylamine in an inert solvent, in addition to which there is also the activation of benzoic acids with dicyclohexylcarbodiimide (DCC) or with O-[(cyano(ethoxycarbonyl)methylene)amino]—1,1,3,3-tetramethyluronium tetrafluoroborate (“TOTU”) [Proceedings of the 21st European Peptide Symposium, Peptides 1990, Editors E. Giralt and D. Andreu, Escom, Leiden, 1991]. A series of suitable methods for preparing activated carboxylic acid derivatives of the formula II is given, with citation of the source literature, on p. 350 in J. March, Advanced Organic Chemistry, Third Edition (John Wiley & Sons, 1985).

[0685] An activated carboxylic acid derivative of the formula II is reacted with guanidine, in a manner known per se, in a protic or aprotic polar, but nevertheless inert, organic solvent. In this context, methanol, isopropanol or THF, at a temperature of from 20° C. up to the boiling temperature of these solvents, have proved of value when reacting the methylbenzoates (II, L=OMe) with guanidine. Most of the reactions of compounds II with salt-free guanidine were advantageously carried out in aprotic inert solvents such as THF, dimethoxyethane or dioxane. However, water can also be used, while employing a base such as, for example, NaOH, as the solvent, when reacting II with guanidine.

[0686] When L denotes Cl, the reaction is advantageously carried out with the addition of an acid-capturing agent, for example in the form of excess guanidine, for binding and thus removing the hydrohalic acid.

[0687] Some of the underlying benzoic acid derivatives of the formula II are known and are described in the literature. The unknown compounds of the formula II may be prepared by methods which are known from the literature. The introduction of some of the substituents is achieved by the methods, which are known from the literature, of palladium-mediated cross-coupling of aryl halides or aryl triflates with, for example, organostannanes, organoboronic acids, organoboranes, or organocopper or organozinc compounds, or terminal alkynes. The resulting benzoic acids are converted into activated benzoic acid derivatives of the formula II by one of the above-described process variants. The compounds of the formula II are either converted directly into the compounds of the formula I according to the invention or transformed initially with guanidine into compounds of the formula III which, following isolation, are converted into the compounds of the formula I according to the invention by reaction with a further compound of the formula II.

[0688] In general, dialkanoyl-substituted guanidines of the formula I are weak bases and can bind acid with the formation of salts. Suitable acid addition salts are the salts of all pharmacologically tolerated acids, for example halides, in particular hydrochlorides, lactates, sulfates, citrates, tartrates, acetates, phosphates, methylsulfonates and p-toluenesulfonates.

[0689] The compounds I are dialkanoyl-substituted guanidines which both directly inhibit the cellular sodium/proton exchanger (Na+/H+ exchanger or Na+/H+ antiporter) and also lose one of their acyl radicals in vivo, with a half life of between 1 minute and 10 hours, and thus, in turn, liberate monoacylguanidines, which are efficient inhibitors of the cellular sodium/proton exchanger. Compounds of the formula I are therefore potent inhibitors of the cellular sodium/proton exchanger and lead to an improvement in the kinetics of the underlying monoacylguanidines. Over and above this, they give rise, owing to their lipophilic nature, to higher concentrations in the CNS of active compounds in the form of dialkanoylguanidines and monoacylguanidines than are achieved using the monoacylguanidines.

[0690] As a consequence of their pharmacological properties, the compounds are outstandingly suitable for use as anti-arrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage; in particular associated with the elicitation of ischemically induced cardiac arrhythmias. On account of their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I according to the invention can, as a consequence of inhibiting the cellular Na+/H+ exchange mechanism, be used as pharmaceuticals for treating all acute or chronic damage elicited by ischemia, or diseases induced primarily or secondarily thereby. This is the case with regard to their use as pharmaceuticals for surgical interventions, for example in organ transplantations, where the compounds can be used both for protecting the organs in the donor prior to and during removal, for protecting organs which have been removed, for example when they are being treated with or stored in physiological bathing fluids, and when transferring the organs into the recipient. The compounds are likewise valuable protective pharmaceuticals to be used when carrying out angioplastic surgical interventions, for example on the heart or on peripheral vessels. In conformity with their ability to protect against ischemically induced damage, the compounds are also suitable for use as pharmaceuticals for treating ischemias of the nervous system, in particular of the CNS, in connection with which they are suitable, for example, for treating stroke or cerebral edema. Over and above this, the compounds of the formula I according to the invention are also suitable for use in the treatment of forms of shock, such as, for example, allergic, cardiogenic, hypovolemic and bacterial shock.

[0691] In addition to this, the compounds of the formula I according to the invention are notable for their strong inhibitory effect on the proliferation of cells, for example the proliferation of fibroblast cells and the proliferation of the smooth muscle cells of the blood vessels. For this reason, the compounds of the formula I are valuable therapeutic agents for use in diseases in which cell proliferation represents a primary or secondary cause and may, therefore, be used as anti-atherosclerotic agents, and as agents against diabetic late complications, cancerous diseases, fibrotic diseases such as pulmonary fibrosis, hepatic fibrosis or renal fibrosis, and against organ hypertrophies or hyperplasias, in particular hyperplasia or hypertrophy of the prostate.

[0692] The compounds according to the invention are efficient inhibitors of the cellular sodium/proton antiporter (Na+/H+ exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes, etc.), is also elevated in those cells which are readily accessible to measurement, such as, for example, erythrocytes, thrombocytes or leucocytes. The compounds according to the invention therefore represent outstanding and simple scientific tools, for example in their use as diagnostic aids for defining and differentiating particular forms of hypertension and also of atherosclerosis, diabetes, proliferative diseases, etc. In addition to this, the compounds of the formula I can suitably be used in preventive therapy for preventing the genesis of high blood pressure, for example of essential hypertension.

[0693] In this context, pharmaceuticals which contain a compound I may be administered orally, parenterally, intravenously or rectally, or by inhalation, the preferred route of administration depending on the given features of the disease. In this context, the compounds I may be used either alone or together with pharmaceutical auxiliary substances, both in veterinary and in human medicine.

[0694] Owing to his specialist knowledge, the person skilled in the art is familiar with those auxiliary substances which are suitable for the desired pharmaceutical formulation. Antioxidants, dispersants, emulsifiers, defoamers, taste corrigents, preservatives, solubilizers or dyes, for example, can be used in addition to solvents, gel formers, suppository bases, tablet auxiliaries and other active compound excipients.

[0695] For a form for oral use, the active compounds are mixed with the additives, such as carrier substances, stabilizers or inert diluents, which are suitable for the purpose, and brought by the customary methods into the forms, such as tablets, coated tablets, hard gelatin capsules, or aqueous, alcoholic or oily solutions, which are suitable for administration. Gum arabic, magnesium hydroxide, magnesium carbonate, potassium phosphate, lactose, glucose or starch, in particular corn starch, can, for example, be used as inert excipients. In this context, the preparation can be effected either as a dry granulate or as a wet granulate. Vegetable or animal oils, for example, such as sunflower oil or cod-liver oil, are suitable for use as oily excipients or as solvents.

[0696] For subcutaneous or intravenous administration, the active compounds are brought into solution, suspension or emulsion, if desired using the substances, such as solubilizers, emulsifiers or other auxiliary substances, which are customary for the purpose. Examples of suitable solvents are: water, physiological sodium chloride solution or alcohols, for example ethanol, propanol or glycerol, as well as sugar solutions, such as glucose or mannitol solutions, or else a mixture of the different solvents mentioned.

[0697] Solutions, suspensions or emulsions of the active compound of the formula I in a pharmaceutically harmless solvent, such as, in particular, ethanol or water, or in a mixture of such solvents, represent examples of suitable pharmaceutical formulations for administration in the form of aerosols or sprays.

[0698] As required, the formulation can also contain additional pharmaceutical auxiliary substances such as surfactants, emulsifiers and stabilizers, as well as a propellent gas. Such a preparation customarily contains the active compound in a concentration of from about 0.1 to 10, in particular of from about 0.3 to 3, % by weight.

[0699] The dosage of the active compound of the formula I to be administered, and the frequency of administration, depend on the strength and duration of the effect of the compounds used; additionally also on the nature and severity of the disease to be treated and on the sex, age, weight and individual responsiveness of the mammalian subject to be treated.

[0700] On average, the daily dose of a compound of the formula I is, for a patient of approximately 75 kg in weight, at least 0.001 mg/kg, preferably 0.01 mg/kg, up to at most 10 mg/kg, preferably 1 mg/kg, of body weight. In acute manifestations of the disease, for example immediately after suffering a cardiac infarction, even greater and, in particular, more frequent dosages may also be necessary, for example up to 4 individual doses per day. In the case of i.v. use in particular, for example in an infarction patient in intensive care, up to 200 mg per day may be necessary.

[0701] List of abbreviations: 5

Bnbenzyl
CH2Cl2dichloromethane
DCIdesorption chemical ionization
DIPdiisopropyl ether
DMEdimethoxyethane
DMFN,N-dimethylformamide
EAethyl acetate (EtOAc)
EIelectron impact
eq.equivalent
ESelectrospray ionization
Etethyl
FABfast atom bombardment
HEPn-heptane
Memethyl
MeOHmethanol
mpmelting point
MTBmethyl tert-butyl ether
Pd/Cpalladium on carbon
Pt/Cplatinum on carbon
RTroom temperature
THFtetrahydrofuran
CNScentral nervous system

[0702] Experimental Section

[0703] General Instructions for Preparing Monoacylguanidines (III)

[0704] Variant A: from Carboxylic Acids (II, L=OH)

[0705] 1.0 eq. of the carboxylic acid derivative of the formula II is dissolved or suspended in anhydrous THF (5 ml/mmol), and 1.1 eq. of carbonyldiimidazole are then added. After the mixture has been stirred at RT for 2 hours, 5.0 eq. of guanidine are introduced into the reaction solution. After the mixture has been stirred overnight, the THF is distilled off under reduced pressure in a rotary evaporator and water is added to the residue, which is adjusted to from pH 6 to 7 with 2N HCl; the corresponding monoacylguanidine (formula III) is then filtered off. The monoacylguanidines obtained in this way can be converted into the corresponding salts by treatment with aqueous, methanolic or ethereal hydrochloric acid or other pharmacologically tolerated acids.

[0706] General Instructions for Preparing Monoacylguanidines (III)

[0707] Variant B: from Alkyl Carboxylates (II, L=O-alkyl)

[0708] 1.0 eq. of the alkyl carboxylate of the formula II and also 5.0 eq. of guanidine (free base) are dissolved in isopropanol or suspended in THF and boiled under reflux until the reaction is complete (monitoring by thin layer chromatography) (typical reaction time, from 2 to 5 h). The solvent is distilled off under reduced pressure in a rotary evaporator and the residue is taken up in EA and washed 3× with a solution of NaHCO3. Drying takes place over Na2SO4, after which the solvent is distilled off in vacuo and the residue is chromatographed on silica gel using a suitable eluent, for example EA/MeOH 5:1.

[0709] (Salt Formation, Compare Variant A)

[0710] General Instructions for Preparing Dialkanoylguanidines (I)

[0711] Variant F: from Carboxylic Acids (II, L=OH)

[0712] 2.0 eq. of the carboxylic acid derivative of the formula II are dissolved or suspended in anhydrous THF (5 ml/mmol), and 2.2 eq. of carbonyldiimidazole are then added. After the mixture has been stirred at RT for 2 hours, 1.0 eq. of guanidine is introduced into the reaction solution. After the mixture has been stirred overnight, the THF is distilled off under reduced pressure in a rotary evaporator, and water is added to the residue, which is adjusted to from pH 6 to 7 with 2M HCl; the corresponding dialkanoylguanidine (formula I) is then filtered off. The monoacylguanidines obtained in this way can be converted into the corresponding salts by treatment with aqueous, methanolic or ethereal hydrochloric acid or other pharmacologically tolerated acids.

[0713] General Instructions for Preparing Dialkanoylguanidines (I)

[0714] Variant G: from Carboxylic Acid Esters (II, L=O-alkyl)

[0715] 2.0 eq. of the alkyl carboxylate of the formula II and also 1.0 eq. of guanidine (free base) are dissolved in isopropanol or suspended in THF and boiled under reflux until the reaction is complete (monitoring by thin layer chromatography) (typical reaction time, from 2 to 5 h). The solvent is distilled off under reduced pressure in a rotary evaporator and the residue is taken up in EA and washed 3× with a solution of NaHCO3. Drying takes place over Na2SO4, after which the solvent is distilled off in vacuo and the residue is chromatographed on silica gel using a suitable eluent, e.g. EA/MeOH 5:1.

[0716] (Salt Formation, Compare Variant A)

[0717] General Instructions for Preparing Dialkanoylguanidines (I)

[0718] Variant K: from Monoacylguanidines (III) and a Carboxylic Acid Derivative of the Formula II (for Example, a Carboxylic Acid Ester or Activated Carboxylic Acid)

[0719] 1.0 eq. of the monoacylguanidine of the formula III (free base) and also 1.0 eq. of the carboxylic acid derivative of the formula II (for the preparation of an activated carboxylic acid, compare variant A) are dissolved or suspended, respectively, in isopropanol or in THF and the mixture is stirred at an appropriate temperature (RT to reflux) until the reaction is complete (monitoring by thin layer chromatography). The solvent is distilled off under reduced pressure in a rotary evaporator and the residue is taken up in EA and washed 3× with a solution of NaHCO3. Drying over takes place Na2SO4, after which the solvent is distilled off in vacuo and the residue is chromatographed on silica gel using a suitable eluent, e.g. EA/MeOH 10:1.

[0720] (Salt Formation, Compare Variant A)

EXAMPLE 1

[0721] Bis(3-methylsulfonyl-4-i-propylbenzoyl)guanidine

[0722] a) 3-Methylsulfonyl-4-i-propylbenzoyl chloride 4.0 g of 3-methylsulfonyl-4-i-propylbenzoic acid, 1.5 ml of thionyl chloride and 3 drops of DMF are heated under reflux for 10 h in 30 ml of toluene. The solvent is subsequently removed in vacuo and the product is taken for further use without purification.

[0723] b) Bis(3-methylsulfonyl-4-i-propylbenzoyl)guanidine The acid chloride 1 a) and 3.9 g of 3-methylsulfonyl-4-i-propylbenzoylguanidine are dissolved in 50 ml of DMF, and 3.4.g of K2CO3 are then added. The mixture is stirred at RT for 4 h and then left to stand overnight. The solution is subsequently concentrated and the residue stirred up in 200 ml of water. The solid is filtered off and washed with 100 ml of water. This solid is then dissolved in 100 ml of EA and washed 1× with 10 ml of 1N HCl and then 1× with 50 ml of NaCl solution. Drying takes place over Na2SO4 and the solvent is removed in vacuo. A yellow solid is obtained which is purified by being triturated twice with 20 ml of diethyl ether and subsequently being filtered off. The product is dried in vacuo and 1.9 g are obtained of a white solid, mp 218-221° C.

[0724] Rf (CH2Cl2/MeOH 20:1)=0.57 MS (ES): 508 (M+1)

[0725] Precursors

[0726] 4-Isopropyl-3-methylsulfonylbenzoylguanidine-methanesulfonate:

[0727] Colorless crystals, mp 226-28° C.

[0728] Synthesis route:

[0729] a) 4-Isopropylbenzoic acid, by the oxidation of 4-isopropylbenzaldehyde with sodium perborate in acetic acid at 50° C., mp 118° C.,

[0730] b) 4-isopropyl-3-chlorosulfonylbenzoic acid, from a) by heating in chlorosulfuric acid at 95° C. for 3 h, mp 203-4° C.,

[0731] c) 2-isopropyl-5-carboxybenzenesulfinic acid, from b) by reduction with sodium sulfite at 60° C. in aqueous sodium hydroxide solution (pH≈9-10), mp 205-7° C.,

[0732] d) 4-isopropyl-3-methylsulfonylbenzoic acid, from c) by alkylation with methyl bromide in the presence of NaOH in DMF at 60° C. for 3 h, mp 209-11° C.,

[0733] e) 4-isopropyl-3-methylsulfonylbenzoylguanidine-methane-sulfonate, from d) by reaction with thionyl chloride in toluene (reflux) for 1 h. After the toluene has been stripped off, the residue is taken up in THF and the resulting acid chloride is added to a mixture of guanidine hydrochloride, 2N NaOH and THF. After the mixture has been stirred at 30-40° C. for 4 h, the THF is distilled off, whereupon the product accrues in crystal-line form as a free base. Subsequent treatment with methanesulfonic acid yields the salt.

EXAMPLE 2

[0734] Bis(4-fluoro-3-trifluoromethylbenzoyl)guanidine

[0735] a) 4-Fluoro-3-trifluoromethylbenzoyl chloride

[0736] 1.5 g of 4-fluoro-3-trifluoromethylbenzoic acid, 0.65 ml of thionyl chloride and two drops of DMF are heated under reflux for 12 h in 17 ml of toluene and the mixture is subsequently concentrated and used without further purification.

[0737] b) Bis (4-fluoro-3-trifluoromethylbenzoyl)guanidine

[0738] The acid chloride 2a) and 0.87 g of 4-fluoro-3-trifluoromethylbenzoylguanidine are dissolved in 15 ml of DMF, and 1.3 g of potassium carbonate are then added. The mixture is stirred at RT for 20 h and then worked up as described under 1b). The resulting, clear oil is purified by column chromatography (silica gel, heptane/EA 8:2), and a colorless solid, mp 143-45° C., is obtained.

[0739] Rf (heptane/EA 7:3)=0.7; MS (ES): 440 (M+1)

[0740] Precursor

[0741] 4-Fluoro-3-trifluoromethylbenzoylguanidine:

[0742] Colorless crystals, mp 159-60° C.

[0743] Synthesis Route:

[0744] 4-Fluoro-3-trifluoromethylbenzoylguanidine, from 4-fluoro-3-trifluoromethylbenzoic acid by reaction with N,N′-carbonyldiimidazole in THF at RT and subsequent addition of guanidine.

EXAMPLE 3

[0745] Bis[4-(1-imidazolyl)-3-trifluoromethylbenzoyl]guanidine

[0746] and

EXAMPLE 4

[0747] N-(4-(1-Imidazolyl)-3-trifluoromethylbenzoyl]-N′-(4-fluoro-3-trifluoromethylbenzoyl)guanidine hydrochloride

[0748] 0.25 g of bis(4-fluoro-3-trifluoromethylbenzoyl)guanidine, 0.16 g of imidazole and 0.16 g of potassium carbonate are heated for 16 h in 5 ml of DMF, and after that the solvent is evaporated. Separation of the crude product by column chromatography yielded 0.12 g of bis[4-(1-imidazolyl)-3-trifluoromethylbenzoyl]guanidine as a colorless solid, mp 130° C., decomp., Rf (CH2Cl2/MeOH 9:1)=0.4 MS (ES): 536 (M+1) and 0.07 g of N-[4-(1-imidazolyl)-3-trifluoromethylbenzoyl]-N′-(4-fluoro-3-trifluoromethyl-benzoyl)guanidine as an oil. Treatment with HCl/ether yielded 0.06 g of N-[4-(1-imidazolyl)-3-trifluoromethylbenzoyl]-N′-(4-fluoro-3-trifluoromethyl-benzoyl)guanidine hydrochloride as a colorless solid, mp 217-218, decomp., Rf (CH2Cl2/MeOH 9:1)=0.53; MS (ES): 488 (M+1)

EXAMPLE 5

[0749] N,N′-Bis(1,2,3,4-tetrahydronaphthalene-2-carbonyl)guanidide was prepared according to variant F from 1,2,3,4-tetrahydronaphthalene-2-carboxylic acid and isolated as a free base.

[0750] MS (ES): 376 (M+1)

[0751] mp 99° C.

[0752] Was also prepared in accordance with variant K via 1,2,3,4-tetrahydronaphthalene-2-carbonylguanidide [prepared in accordance with variant A from 1,2,3,4-tetra-hydronaphthalene-2-carboxylic acid: MS (ES): 218 (M+1)]and 1,2,3,4-tetrahydronaphthalene-2-carboxylic acid.

EXAMPLE 6

[0753] N,N′-Bis[(E)-2-methylcinnamoyl]guanidide was prepared from (E)-2-methylcinnamic acid in accordance with variant F and isolated as the hydrochloride.

[0754] MS (ES): 348 (M+1)

[0755] mp 193° C.

EXAMPLE 7

[0756] N,N′-Bis[3-(2-trifluoromethylphenyl)propionyl]guanidide was prepared from 3-(2-trifluoromethylphenyl)propionic acid in accordance with variant F and isolated as the hydrochloride.

[0757] MS (ES): 460 (M+1)

[0758] mp 75° C.

EXAMPLE 8

[0759] N,N′-Bis[3-(2,5-difluorophenyl)-2-methylpropionyl)guanidide was prepared from 3-(2,5-difluorophenyl)-2-methylpropionic acid in accordance with variant F and isolated as the hydrochloride.

[0760] MS (ES): 424 (M+1)

[0761] mp amorphous

[0762] Pharmacological Data:

[0763] Inhibition of the Na+/H+ exchanger of rabbit erythrocytes:

[0764] New Zealand White rabbits (Ivanovas) were given a standard diet containing 2% cholesterol for six weeks in order to activate Na+/H+ exchange and thus to be able to use flame photometry to determine the Na+ influx into the erythrocytes via Na+/H+ exchange. The blood was removed from the aural arteries and rendered incoagulable by the addition of 25 IU of potassium heparin per ml. One part of each sample was used for the duplicate determination of the hematocrit by centrifugation. Aliquots of in each case 100 μl were employed for measuring the initial content of Na+ in the erythrocytes.

[0765] In order to determine the amiloride-sensitive sodium influx, 100 μl of each blood sample were in each case incubated, at pH 7.4 and 37° C., in 5 ml of a hyperosmolar salt/sucrose medium (mmol/l: 140 NaCl, 3 KCl, 150 sucrose, 0.1 ouabain, 20 tris(hydroxymethyl)amino-methane). The erythrocytes were then washed three times with ice cold MgCl2/ouabain solution (mol/l: 112 MgCl2, 0.1 ouabain) and hemolyzed in 2.0 ml of distilled water. The intracellular content of sodium was determined by flame photometry.

[0766] The nett influx of Na+ was calculated from the difference between the initial sodium values and the sodium content of the erythrocytes following incubation. The amiloride-inhibitable sodium influx was given by the difference in the sodium content of the erythrocytes following incubation with and without 3×10−4 mol/l amiloride. The same procedure was also used in the case of the compounds according to the invention.

[0767] Results relating to the inhibition of the Na+/H+ exchanger: 6

IC50 (μmol)Example
101
102
53
34
0.35
1.16
27
0.38

[0768] The following were obtained in analogy with Example 1: 7

ExampleR(1) = R(10)R(2) = R(9)R(3) = R(8)R(4) = R(7)R(5) = R(6)
9HHCln-BuNH—H
10HH 23embedded image H2NSO2H
11HH 24embedded image MeSO2H
12H 25embedded image MeHH
13H 26embedded image 27embedded image HH
14H 28embedded image MeHH
15H 29embedded image ClHH
16H 30embedded image MeSO2HH
17HHNH2MeSO2H
18HH 31embedded image MeSO2H
19HH 32embedded image MeSO2H
20HH 33embedded image MeSO2H
21HH 34embedded image MeSO2H
22HH 35embedded image MeSO2H
23HH 36embedded image MeSO2H
24HH 37embedded image Cl2H
25HH(CH3)2—CHCH2—O—MeSO2H
26HH 38embedded image MeSO2H
27HH 39embedded image MeSO2H
28HH 40embedded image MeSO2H
29H 41embedded image 42embedded image HH
30H 43embedded image 44embedded image HH
31H 45embedded image 46embedded image HH
32H 47embedded image 48embedded image HH
33H 49embedded image 50embedded image HH
34H 51embedded image 52embedded image HH
35HH 53embedded image MeSO2H
36HH 54embedded image MeSO2H
37MeHHMeH
38HMeMeH2NSO2H
39HHHCF3H
40H 55embedded image ClHH
41HHMeNH—MeSO2H
42HHEt2N—MeSO2H
43Ht-BuOHt-BuH
44HH 56embedded image MeSO2H
45HH 57embedded image MeSO2H
46HH 58embedded image MeSO2H
47HH 59embedded image MeSO2H
48HH 60embedded image MeSO2H
49HH2-naphthylMeSO2H
50HH 61embedded image MeSO2H
51H 62embedded image MeHH
52H 63embedded image 64embedded image HH
53HClEt2N—MeSO2H
54HMe2N—HCF3H
55HH 65embedded image MeSO2H
56HBrNH2BrH
57HClHCF3H
58HH 66embedded image MeSO2H
59HH 67embedded image MeSO2H
60HCF3HCF3H
61HHMeMeH
62HIHCF3H
63HMeHMeH
64HHt-BuHH
65HH 68embedded image MeSO2H
66HHClMeH
67HHMeBrH
68HHMeO—ClH
69HClMeO—ClH
70HBrHBrH
71HH 69embedded image MeSO2H
72HH 70embedded image MeSO2H
73NH2BrHMeH
74HN3HCF3H
75HHt-BuMe2N—H
76HH 71embedded image MeSO2H
77H 72embedded image HHH
78H 73embedded image MeO—HH
79HHBrMeH
80HHFClH
81Ht-BuHt-BuH
82NH2HHClH
83H 74embedded image HMe2NH
84HMe2NHClH
85HH7-iso-quinolinoxyMeSO2H
86HH6-quinolinoxyMeSO2H
87HH 75embedded image MeSO2H
88HH 76embedded image MeSO2H
89HH(CH3)2CH—CH2MeSO2H
90HH 77embedded image MeSO2H
91HH 78embedded image Me2N—H
92HH 79embedded image Me2N—H
93HMeMe2NMeH
94HH 80embedded image 81embedded image H
95HMe 82embedded image MeH
96HHClCH═C(CH3)—MeSO2H
97HHi-PrClH
98HHi-Pr 83embedded image H
99HH5-quinolinoxyMeSO2H
100H 84embedded image HCF3H
101Hi-PrHMeSO2H
102Hi-PrHCF3H
103HHi-PrHH
104NH2HBrBrH
105HH 85embedded image MeSO2H
106H 86embedded image HMeSO2H
107HH 87embedded image MeSO2H
108HCl 88embedded image ClH
109HMe2Ni-PrMeSO2H
110HMeHN—i-PrMeSO2H
111HClClClH
112HClH2N—MeH
113HClH2NClH
114HH 89embedded image MeSO2H
115HH 90embedded image MeSO2H
116HHi-PrMe2N—H
117CF3HHCF3H
118HBrHMeH
119HMeClMeH
120HMe2NMeBrH
121HCF3HMeHN—H
122HH(CH3)2CH—CH2CH3CO—H
123HH 91embedded image MeSO2H
124HHHCF3—O—H
125HHMe2NMeH
126HCl 92embedded image ClH
127HClMe2N—ClH
128HH 93embedded image MeSO2H
129HHi-PrCH3CO—H
130HBrBnO—CH3CO—H
131HHBrCF3H
132HHMeO—i-PrH
133HH 94embedded image MeSO2H
134HH 95embedded image MeSO2H
135HHt-BuMeO—H
136HBri-PrMeSO2H
137CF3HHHH
138HHFCF3H
139HPhHCF3H
140HHi-imidazolylCF3H
141HHcyclopentylCH3CO—H
142HHt-butylmethylCH3CO—H
143HHFBrH
144HBrMeO—BrH
145NH2MeHHH
146HHPhO—CF3H
147HHcyclopentylCF3H
148HHcyclobutylMeSO2H
149HMeHCF3H
150HH4-CF3—PhOMeSO2H
151HHOHt-butylH
152HMe2N—MeO—ClH
153HHisopropylCF3H
154HCF3HHF
155HHMeO—t-butylH
156HH 96embedded image MeSO2H
157HBr 97embedded image BrH
158HH 98embedded image MeSO2H
159HH 99embedded image CH3CO—H
160HH 100embedded image CH3CO—H
161HHmethylpropylt-butylH
162HcyclopentylMeO—CH3CO—H
163HHisopropylCF3CF2H
164HH 101embedded image CF3SO2H
165HCF3HHCl
166HH 102embedded image CF3H
167HHPh—C═CCF3H
168HH 103embedded image CF3H
169HFHCF3H
170HH 104embedded image MeSO2H
171HHisopropylt-butylH
172HHn-butylt-butylH
173HHFisopr pylH
174HHFisobutylH
175HIHCF3F
176HHCF3O—ClH
177NH2HClHCl
178HH 105embedded image MeSO2H
179HIOHt-butylH
180HHisopropylCF3SO2H
181HH 106embedded image CF3H
182HH 107embedded image CF3H
183HH 108embedded image CF3H
184HH 109embedded image CF3H
185HH 110embedded image CF3H
186HHMeO—CF3H
187HHHisopropylH
188HHisopropylMeS—H
189 111embedded image
190 112embedded image
191 113embedded image
192 114embedded image
193 115embedded image
194 116embedded image
195 117embedded image
196 118embedded image
197 119embedded image
198 120embedded image
199 121embedded image
200 122embedded image
201 123embedded image
202 124embedded image
203 125embedded image
204 126embedded image