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10101334 Multiplex MRM assay for evaluation of cancer  
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (ER), progesterone receptor (PR), and/or antigen Ki67 (Ki67)...
10101330 Protein and autoantibody biomarkers for the diagnosis and treatment of lung cancer  
Aspects of the present disclosure include methods of producing a circulating analyte profile of a subject. The methods include contacting a blood sample from a subject with a panel of probes for...
10100314 Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy  
In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a Salmonella strain comprising a...
10100119 Anti-human interleukin-1 receptor accessory protein antibody and its use for treating cancer  
The present invention provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein (IL1RAP) wherein the antibody or...
10100078 Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in fields of medicine including cancer treatment and food related compounds  
The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not...
10100034 Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts  
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin -7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of...
10100019 N2-(2-methoxyphenyl)pyrimidine derivative, method for preparing same, and pharmaceutical composition for cancer prevention or treatment containing same as active ingredient  
The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising...
10098952 Inorganic nanoparticles compositions in combination with ionizing radiations for treating cancer  
The present application relates to activable inorganic nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cancerous cells,...
10098933 Compositions of engineered human arginases and methods for treating cancer  
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate...
10098917 Parovirus having a CpG-enriched genome useful for cancer therapy  
A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of...
10098900 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases  
Described herein are combination therapies for cancer (such as lymphoid malignancies) and immune diseases (such as autoimmune diseases and inflammatory diseases). The therapies comprise the...
10098880 Combination of nelfinavir, metformin and rosuvastatin for treating cancer caused by aberrations in PTEN/TP53  
The present disclosure relates to a method of treating cancer using a composition comprising Nelfinavir, Metformin, Rosuvastatin, optionally along with a pharmaceutically acceptable excipient. The...
10098860 Bezafibrate for the treatment of cancer  
Methods of treating renal cancer, including renal cell carcinoma, using bezafibrate are disclosed herein. Bezafibrate can be administered as a monotherapy or as part of a comprehensive treatment...
10098852 Indication of monobenzone pharmaceutical composition for treating cancer  
A method for treating a cancer includes administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising Monobenzone or a pharmaceutical...
10096110 System and method for automated stereology of cancer  
This invention relates to a system and method for applying an ensemble of segmentations to microscopy images of a tissue sample to determine if the tissue sample is representative of cancerous...
10095829 Computer implemented methods of treating lung cancer  
The present invention concerns a method for predicting the relative efficacy of a plurality of drugs for treating a tumor in an individual comprising the molecular characterization of the tumor,...
10094837 Cadherins as cancer biomarkers  
Methods of isolating, enriching, capturing, identifying, or detecting the presence of, cancerous cells in a sample, e.g., a blood sample from a subject, by detecting the presence of one or more...
10094834 Method of selecting individualized brain cancer therapy  
The present invention relates to a method of selecting individualized brain cancer therapy on the basis of the patient's PME-1 expression level in the diseased tissue.
10094832 Cervical cancer-related HPV E7 protein monoclonal antibody and use thereof  
The present invention provides an anti-HPV E7 protein monoclonal antibody and the use thereof. The antibody can detect the HPV16 E7 protein with high specificity and recognize the HPV18 E7...
10093977 Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them  
Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or...
10093934 SDF-1 binding nucleic acids and the use thereof in cancer treatment  
The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid molecule is for use in a method for the...
10093930 Targeting WSB1 and pVHL to treat cancer  
Materials and methods for treating cancer (e.g., by reducing metastasis) are provided herein. For example, materials and methods for treating cancer by targeting WSB1 and/or pVHL are provided.
10093740 Bispecific HER2 ligands for cancer therapy  
The invention relates to a bispecific HER2-targeting agent comprising a.) a first polypeptide ligand that binds to HER2 extracellular domain 1, b.) a second polypeptide ligand that binds to HER2...
10093736 Agents for treatment of claudin expressing cancer diseases  
The present invention provides binding agents that contain a binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor-associated...
10093716 Methods for treating cancer  
The present invention relates to methods and materials for treating an individual with KRAS-mutated cancer or a cancer in which ROCK is inhibited independently of mutated KRAS. The invention is...
10093689 Composition containing a gold (I) complex and cancer cells  
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a...
10093621 4-oxo-N-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer  
The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: wherein:X is —COOH or NH2;R is a straight or branched C1-C10 alkylene chain;...
10092659 Duocarmycin ADCs for use in treatment of endometrial cancer  
The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors expressing HER2, wherein the human solid tumor expressing...
10088482 Prognosis of oesophageal and gastro-oesophageal junctional cancer  
The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of:...
10087489 Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease  
Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such...
10087487 Method for determining risk of metastatic relapse in a patient diagnosed with colorectal cancer  
The method for determining risk of metastatic relapse in a patient diagnosed with colorectal cancer (CRC) can include detecting a level of at least one indicator of metastatic potential in a...
10087448 Synthetic lethality in cancer  
There is described herein compounds, compositions and methods for inducing synthetic lethality in a cancer cell(s).
10086214 Integrated tomography—cancer treatment apparatus and method of use thereof  
The invention relates to a method and apparatus for generation of two-dimensional images using X-rays, proton tomography, and/or carbon ion tomography to form one or more independent and/or...
10086055 Adherent cancer cell line expressing a hematological tumor antigen  
The present invention relates to a transduced cancer cell line stably expressing a leukemia tumor antigen, wherein the cancer cell line is cervical cancer cells, breast cancer cells, ovarian...
10086037 Compositions and methods to prevent cancer with cupredoxins  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
10086018 Method and system for reducing the likelihood of colorectal cancer in a human being  
A system and method for reducing the likelihood of colorectal cancer in a human being includes the modification of an individual's gut microbes by employing a Clustered Regularly Interspaced Short...
10086010 Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells  
In one embodiment, the invention provides a method of treating a subject who suffers from a neoplasm (including a cancer such as a radiotherapeutic-resistant cancer) by administering to the...
10085962 Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders  
Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective...
10085953 Skin cancer treatment  
A compound of formula (I) R-L-CO—X (I) wherein R is a C10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO,...
10085950 Pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients  
The present invention relates to a pharmaceutical composition for cancer treatment containing gossypol and phenformin as active ingredients. Specifically, the combinative treatment with gossypol...
10082510 SRC-2 use as metabolic biomarker for diagnosis and treatment of metastatic prostate cancer  
Embodiments of the disclosure include methods and compositions for treatment of prostate cancer, including metastatic prostate cancer or prostate cancer at risk for developing into metastatic...
10081842 Prostate cancer gene expression profiles  
The present disclosure provides gene expression profiles that are associated with prostate cancer. The gene expression profiles can be used to detect prostate cancer cells in a sample and to...
10081682 Conjugated antibodies against LY75 for the treatment of cancer  
The invention provides antibodies which bind to LY75. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided....
10081679 Compositions comprising anti-CEACAM1 and anti-PD antibodies for cancer therapy  
The present invention provides compositions comprising anti-CEACAM1 antibodies, compositions comprising antibodies capable of inhibiting or blocking the interaction between PD-1 and its ligands,...
10081668 Modified pigment epithelium-derived factor (PEDF) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection  
Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier...
10081628 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds. One...
10080776 Molecular marker for cancer stem cell  
A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of...
10080739 Aryl imidazoles and their use as anti-cancer agents  
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone...
10078895 Prediction of recurrence of non-small cell lung cancer with tumor infiltrating lymphocyte (TIL) graphs  
Methods and apparatus predict non-small cell lung cancer (NSCLC) recurrence using radiomic features extracted from digitized hematoxylin and eosin (H&E) stained slides of a region of tissue...
10077316 Esophageal cancer marker and use thereof  
The present invention relates to an esophageal cancer marker and application thereof. The present invention relates to: a marker that includes Glypican-1 or an expression product thereof, or a...