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7640115 |
Diagnostic method of selecting appropriate cancer treatments and screening method of measuring reagents and curative medicines for cancer patients
A method is provided to study gene function based on variations of the amino acids and the base sequences at specific positions on HLA genes which have polymorphisms and codon usage Medical...
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7640114 |
Method of diagnosis of cancer based on gene expression profiles in cells
A method of developing a gene expression profile indicative of the presence or stage of a selected a disease, disorder or genetic pathology in a mammalian subject employs penalized discriminant...
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7638528 |
Compositions and methods for targeting cancer cells
The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus...
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7638331 |
Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
The present invention provides methods and constructs for selectively expressing an Apoptosis-Inducing Gene (AIG) in a population of cells that overexpress cyclooxygenase-2 (COX-2) to induce...
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7638278 |
Markers of DNA copy number alteration for improved prognostication in prostate cancer
The invention describes DNA copy number alterations (CNAs), identifiable by technologies such as array-based comparative genomic hybridization (array CGH) or fluorescence in situ hybridization...
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7638274 |
Polynucleotide associated with a colon cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing a colon cancer using the polynucleotide
Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a...
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7638272 |
Cancer therapy sensitizer
The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well...
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7638270 |
Nucleic acids and corresponding proteins entitled 254P1D6B useful in treatment and detection of cancer
A novel gene 254P1D6B and its encoded protein, and variants thereof, are described wherein 254P1D6B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
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7638127 |
Peptide conjugated anti-cancer prodrugs
The present invention relates to pharmaceutical compositions that include a targeting peptide, a protease specific cleavable peptide, and a chemotherapeutic drug that when conjugated are...
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7638122 |
Stat3 antagonists and their use as vaccines against cancer
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing...
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7635759 |
Gene encoding labyrinthin, a marker for cancer
A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to...
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7635753 |
Prostate cancer and melanoma antigens
Methods for identifying a human subject as a candidate for further prostate cancer or melanoma examination are disclosed. Also disclosed are methods for determining whether an immune therapy has...
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7635693 |
Methods for preventing and treating cancer using N-thiolated ��-lactam compounds and analogs thereof
The subject invention concerns N-thiolated β-lactam compounds of formula A,
wherein R 1 is a hydrocarbon group having 1-8 carbon atoms; R 3 is an organothio group; and R 4 is alkyl,...
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7635561 |
Methods of diagnosing, prognosing and treating breast cancer
The protein pRb2/p130 represses expression of the ER-α gene. Blocking pRb2/p130 expression or altering ER-α gene methylation to alter pRb2/p130 complex binding allows transcriptional activity of...
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7635560 |
Pygopus in diagnosis and treatment of cancer
Expression of pygopus mRNA and Pygopus protein in established cancer cell lines and in patient tumors is described. Pygopus is shown to be a feasible diagnostic and prognostic indicator. Pygopus is...
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7632972 |
Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells
Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of...
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7632855 |
Pyrazole compounds as HSP90 inhibitors for the treatment of cancer
Compounds of formula (I) are inhibitors of HSP90 activity, and useful in the treatment of proliferative disease such as cancers: wherein R 1 , R 2 and R 3 are as defined in the specification, and...
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7632827 |
Anti-cancer phosphine containing [AuIIIm(CNC)mL]n+ complexes and derivatives thereof and methods for treating cancer using such compositions
Gold(III) phosphine complexes [Au m (CNC) m L] n+ (where HCNCH=2,6-diphenylpyridine) and their use as anti-tumor agents are disclosed. Notable results for the appearance of new potential...
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7632814 |
HYD1 peptides as anti-cancer agents
The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the...
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7632802 |
S100 protein as neutrophil activator for alleviating neutropenia in cancer treatment
The present invention relates to a method and composition for inducing lymphocyte proliferation and migration, and for reducing the risks of microbial infections in patients immuno-suppressed. The...
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7632678 |
Cancer stem cells and uses thereof
Disclosed are enriched preparations of neuroblastoma tumor initiating cells (NB TICs). The NB TICs are capable of self-renewal, initiating neuroblastoma tumor growth in vivo and are capable of...
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7632634 |
Method and assay for early diagnosis of prostate cancer
A method and assay are described for determining prostate cancer and the general stage of progression of such cancer by quantifying levels of expression of different galectin isoforms and/or...
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7632496 |
Co-administration of cG250 and IL-2 or IFN-�� for treating cancer such as renal cell carcinomas
A method for enhancing the therapeutic effect of cytokine treatment is disclosed. More specifically the present invention relates to a method for administering to a tumor patient a therapeutic dose...
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7632295 |
Ferroelectric hyperthermia method for cancer treatment
A method of localized cell heating introduces a plurality of ferroelectric comprising particles into a target region of a patient, and applies a time varying electrical field to the target region....
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7630759 |
Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium
A method and system are provided for determining a condition of a selected region of epithelial and stromal tissue in the human breast. A plurality of measuring electrodes are used to measure the...
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7629364 |
Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically,...
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7629325 |
Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors (e.g., skin caner) are provided. Specifically, the method is effected by administering to a subject in need...
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7629310 |
RhoB as a suppressor of cancer cell growth, cell transformation, and metastasis
The present invention concerns the use of the protein RhoB and its variants to inhibit cancer cell growth, migration, invasion, metastasis, malignant cell transformation, and/or to modulate...
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7629114 |
Method of collecting nasopharyngeal cells and secretions for diagnosis of viral upper respiratory infections and screening for nasopharyngeal cancer
The present invention provides a method of collecting nasopharyngeal specimens by introducing physiologic solution into the conjunctival sacs and collecting the irrigate that drains into the...
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7625563 |
Cancer treatment methods using selected immunoconjugates for binding to aminophospholipids
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7625553 |
Method of treating cancer by administering an epithelum-derived T-cell factor
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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7622630 |
Chimeric cancer models
Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells...
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7622569 |
Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer
A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is...
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7622568 |
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this...
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7622557 |
Antibodies having binding specificity for the extracellular domain of a breast cancer resistance protein (BCRP)
The present invention includes methods of identifying and/or isolating stem cells based on expression of BCRP. The present invention also describes methods of obtaining and/or using cell...
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7622556 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7622458 |
Combination of ET-743 and a 5-fluorouracil pro-drug for cancer treatment
Methods of treating a human body for cancer are provided. In one aspect, a therapeutic amount of capecitabine is administered in combination with ET-743 in a dose range between 0.75 and 1.4 mg/m 2 ...
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7622456 |
Method on clinical applications in head neck cancer by using DSG3 molecule for predicting malignant degree of cancer, serving as a molecular target and using RNA jamming sequence on inhibition-specific of DSG3 expression
The present invention provide a method for analyzing the DSG3 overexpression in tumor tissues with clinical features of cancer cells to validate that DSG3 overexpression is relates to size, depth...
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7622261 |
Method for the diagnosis of cancers by measuring the changes of glycosylation of proteins related to tumorigenesis and metastasis and kit for diagnosis of cancers using the same
The present invention relates to a method for diagnosing cancers by measuring proteins associated with tumorigenesis and metastasis, and a diagnostic kit using the same, particularly relates to the...
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7622255 |
Methods of identifying and isolating stem cells and cancer stem cells
Methods and compositions are provided for the identification of stem cells and cancer stem cells. β-catenin is also identified as a target for the development of therapeutic moieties against...
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7622251 |
Molecular indicators of breast cancer prognosis and prediction of treatment response
The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer....
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7622119 |
Cancer antigen peptides derived from WT1
The present invention relates to HLA-A26-binding cancer antigen peptides derived from WT1, polynucleotides encoding such a peptide, CTL-inducers, and cancer vaccines comprising such a peptide or...
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7622118 |
Cancer treatment methods using selected antibodies to aminophospholipids
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7622105 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7619057 |
MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are...
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7619000 |
S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent...
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7618992 |
Method of treating cancer by co-administration of anticancer agents
The present invention relates to a method of treating cancer by co-administration of an effective amount of...
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7618981 |
Imidazopyridinyl-benzamide anti-cancer agents
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
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7618939 |
Compositions and methods to prevent cancer with cupredoxins
The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in...
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7618936 |
Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.
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