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7368576 |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for treating conditions mediated b...
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7368548 |
Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer
Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These...
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7367988 |
Use of electromagnetic fields in cancer and other therapies
Methods and apparatus are described for the treatment of diseases by exposures to electromagnetic fields. Also, apparatus is described for focusing the biological effectiveness of such fields on sp...
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7364862 |
Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer.
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7364727 |
Metastatic colon cancer specific promoter and uses thereof
Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in sp...
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7364726 |
Pharmaceutical composition for cancer treatment containing cells that express a membrane cytokine
This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a cytokine-secr...
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7361691 |
Method of treating cancers using β-lapachone or analogs or derivatives thereof
Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic ki...
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7361680 |
Indole compounds useful for the treatment of cancer
The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.
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7361511 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, cha...
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7361474 |
Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer
The present invention provides methods for detecting, diagnosing or prognosticating prostate cancer by measuring the levels of macrophage migration inhibitory factor (MIF) in the serum of an indivi...
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7361360 |
Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response
The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation...
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7361342 |
Cancerous disease modifying antibodies
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer ce...
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7361341 |
Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other ...
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7361338 |
Methods to inhibit growth of prostate cancer cells
A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberran...
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7361336 |
Methods of cancer therapy targeted against a cancer stem line
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous ca...
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7358361 |
Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the con...
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7358353 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers inc...
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7358274 |
Methods for treating or preventing cancer using Benzopyranone Compounds
This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neopla...
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7358231 |
Pancreatic cancer secreted targets and uses thereof
The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic...
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7358046 |
Sensitivity test to predict efficacy of anti-cancer therapies
The present disclosure provides methods for determining the sensitivity of cancerous cells to various anti-cancer therapies and predicting the efficacy of these therapies. Specifically, the present...
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7354992 |
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this ...
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7354713 |
Method of using estrogen-related receptor gamma (ERRγ) status to determine prognosis and treatment strategy for breast cancer, method of using ERRγ as a therapeutic target for treating breast cancer, method of using ERRγ to diagnose breast cancer, and method of using ERRγ to identify individuals predisposed to breast cancer
The present invention provides that ERRγ is both a breast cancer biomarker and a breast cancer treatment target. A high ERRγ level in breast cancer cells indicates good prognosis. A high level of...
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7354705 |
Methods for cancer prognosis and diagnosis
The invention provides methods for prognosis and diagnosis in human cancer patients comprising detecting in human tumor tissues the infiltration of certain immune cells associated with poor cancer ...
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7354580 |
Method of administering and using VEGF inhibitors for the treatment of human cancer
A method of treating a human patient suffering from cancer, comprising administering an effective amount of a vascular endothelial growth factor (VEGF) trap antagonist to the human patient, the met...
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7354579 |
Method of treating cancer with a VEGF antagonist and an anti-proliferative agent
Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth...
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7351729 |
JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective am...
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7351689 |
Use of IL-28 and IL-29 to treat cancer and autoimmune disorders
Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29...
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7351530 |
Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer
The present invention provides a method for detection of loss of heterozygosity (LOH) at human chromosome segment 11p15.5 in a tumor sample from a patient with non-small-cell lung cancer (NSCLC), a...
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7348413 |
Cancerous disease modifying antibodies
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer ce...
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7348165 |
Methods for detecting cancer cells by using nucleic acid encoding for IGF-1 receptor interacting proteins
The invention relates generally to a method for the detection of the proliferation of a tumor cell and more specifically wherein said method comprises nucleic acids (SEQ ID NO:1) encoding IIP-1.
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7348142 |
Cancer diagnostic panel
A method of diagnosing cancer by identifying differential modulation of each gene (relative to the expression of the same genes in a normal population) in a combination of genes selected from two g...
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7348139 |
SOCS-1 gene methylation in cancer
Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 prot...
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7348015 |
Antigen modified cancer cell vaccines for cancer therapy
Disclosed are methods for treating cancers, particularly tumorigenic types. Cancer cells are modified to express highly immunogenic antigens so that the cells will generate a defensive response in ...
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7348010 |
Vaccine against cancer diseases that are associated with the her-2/neu oncogene
The present invention relates to peptides of the extracellular domain of a HER-2/neu protein, conjugates comprising said peptides linked to an immunogenic carrier, compositions thereof, nucleic aci...
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7348008 |
Ricin-like toxins for treatment of cancer
The present invention provides a protein having chain of a ricin-like toxin, a B chain of a ricin-like toxin and a novel heterologous linker amino acid sequence, linking the A and B chains. The lin...
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7348003 |
Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of can...
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7346144 |
In vivo planning and treatment of cancer therapy
A system and method for delivering radiation to an object. A computer tomography machine generates CT data of the object. A radiation source with an output beam is directed to a predetermined irrad...
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7345039 |
Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidi...
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7344740 |
Methods and apparatus to prevent, treat, and cure the symptoms of nausea caused by chemotherapy treatments of human cancers
Methods and apparatus are provided to prevent, treat, and cure chemotherapy induced nausea in human beings. The inhalation of an effective amount of vaporized essential oil from Mentha piperita (...
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7344721 |
Polypeptide for the treatment of cancer and a method for preparation thereof
This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apop...
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7344711 |
Use of adenoviruses mutated in the VA genes for cancer treatment
This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene seq...
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7344700 |
Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and in treating or preventing prostate cancer. The agents define a new-subclass of ...
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7342109 |
Human kinase interacting protein 2 (KIP2)-related gene variant associated with cancers
Nucleic acid and polypeptide sequences of one novel human KIP2-related gene variant (KIP2V), and the processes for producing the same are provided. Use of the nucleic acid and polypeptide sequences...
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7342092 |
Cancer antigen peptide formulations
Cancer antigen peptides derived from WT1 which have an in vivo efficacy, particularly a clinical usefulness, and cancer vaccines as dosage forms suitable for said cancer antigen peptides, are provi...
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7342004 |
Thioether sulphamate steroids as steroid inhibitors and anti-cancer compounds
There is provided use of a compound of Formula XI:
wherein R 3 is a sulphamate group and at least of R 1 or R 2 is a thioether group as disclosed by the present specification, capable of inh...
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7341749 |
Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer
A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia)...
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7341739 |
Small particle liposome aerosols for delivery of anti-cancer drugs
The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are admi...
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7341724 |
Polypeptide for the treatment of cancer and a method for preparation thereof
This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apop...
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7341721 |
β2-microglobulin (β2m) and anti-β2m binding agents as anti-cancer therapeutics
The present invention describes the use of agents that interact with major histocompatibility complex (MHC) HLA class I molecules, such as β 2 -microglobulin, or antibodies that bind to β 2 -micr...
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7340292 |
Breast cancer detection system
A method for detecting breast cancer can include the step of positioning a transmitting antenna and a receiving antenna about a breast so that the transmitting antenna is positioned to transmit mic...
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