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7175839 |
Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy
This invention provides medicaments and methods for managing cancer using donor cells that are alloactivated in culture. Alloactivated cells are implanted into the bed of a solid tumor and initiate...
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7173021 |
Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers
This invention relates to the use of temozolomide esters (4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-
carboxylate esters) Formula 1 as potent anticancer pro-drugs for treatment of...
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7173006 |
Drug comprising synthetic peptide analogs for the treatment of cancer
The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma...
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7172898 |
103P2D6: tissue specific protein highly expressed in various cancers
A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence...
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7172889 |
Biological compositions and methods for treatment of cervical cancer
The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with cervical cancer. The...
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7172888 |
Biological compositions and methods for treatment of lung cancer
The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with lung cancer. The...
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7171311 |
Methods of assigning treatment to breast cancer patients
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
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7169813 |
4-oxo-fenretinide, administered alone and in combination with fenretinide, as preventive and therapeutic agent for cancer
A drug based on a metabolite of fenretinide, or N-(4hydroxyphenyl) retinamide (4-HPR), specifically 4-oxo-N-(4-hydroxyphenyl) retinamide (4-oxo-4-HPR), is used in the treatment of different kinds...
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7169390 |
Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation
Methods and compositions are disclosed that are useful for the prevention and/or treatment of cancer, angiogenesis, and inflammation. The beneficial effects of the compositions and methods are...
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7169388 |
Methods of inhibiting TNFα in patients with cancer
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated...
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7166744 |
Retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds
The present invention relates to a novel retinoid derivative compound represented by the formula I:
wherein X, R 1 , R 2 and R 3 are as defined herein or pharmaceutically acceptalbe salts...
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7166714 |
Serpentine transmembrane antigens expressed in human cancers and uses thereof
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
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7166704 |
Antibodies immunologically specific for PD2, a protein that is amplified and overexpressed in pancreatic cancer
A human nucleic acid, PD2, its encoded protein and antibodies immunologically specific thereto are disclosed herein. The expression of the disclosed PD2 gene plays a key role in the regulation of...
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7166694 |
Vaccine against cancerous diseases which is based on mimotopes of antigens expressed on tumor cells
The present invention provides a method for producing a vaccine against cancerous disease, and the vaccine itself. This method involves first using one or more antibodies that are specifically...
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7166573 |
Breast, gastric and prostate cancer associated antigens and uses therefor
Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in breast, gastric and prostate cancer cells using antisera from cancer...
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7166295 |
Methods of treatment and diagnostic visualization, particularly in cancer
Methods and reagents for improved treatment and diagnostic imaging, particularly of cancer. The methods and reagents utilize specific targeting of treatment and imaging ligands to the targeted...
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7166286 |
Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for prophylaxis and detection of cancers
The present invention relates to monoclonal antibody H11 and antigen binding fragments that specifically bind to the antigen recognized by H11, the C-antigen. The C-antigen is found specifically on...
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7163925 |
p16 expression constructs and their application in cancer therapy
A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, expression constructs are provided that...
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7163813 |
Biological compositions and methods for treatment of colorectal cancer
The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with colorectal cancer. The...
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7163801 |
Methods for determining the prognosis for cancer patients using tucan
The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the...
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7163789 |
Cancer diagnosis method
The invention concerns a method for the diagnosis and/or the follow up of the evolution of cancer comprising the analysis of the RNA components of the telomerase enzyme present in the plasma or...
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7163680 |
Treatment and diagnosis of cancer
The present invention is directed to the use of antibodies or binding portions thereof, probes, ligands, or other biological agents which either recognize an extracellular domain of prostate...
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7160865 |
Cancer treatment including glycolytic inhibitors
Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as...
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7160716 |
Device for inducing an immune response in cancer therapy
A device for inducing an immune response in cancer therapy in which isolated living malignant tissue is enclosed in a space formed by a microporous membrane and a holder which is introduced into a...
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7160697 |
Use of novel cytokine receptors as biomarkers and therapeutic targets in human cancer
Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.
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7160679 |
Method of diagnosing, monitoring, and staging lung cancer
The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating lung cancer.
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7160239 |
Method of breaking cancer cell tissue by microelectromagnetic radiation and microelectromagnetic radiator
A means and apparatus for breaking non-cellular tissues such as cancer cells to be used in medical treatments for human or animal body wherein heat energy is generated due to electric field energy...
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7157551 |
Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers
Compositions and methods involving agents that specifically bind to methylthioadenosine phosphorylase (MTAP) protein are disclosed. Illustrative compositions comprise binding agents that bind to...
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7157438 |
Rhob as a suppressor of cancer cell growth and cell transformation
The protein RhoB and its variants as a supressor of cancer cell growth, inhibitor of malignant cell transformation, and modulator of oncogenic signaling, wherein introducing RhoB directly, or...
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7153946 |
Molecular conjugates for use in treatment of cancer
A molecular conjugate is provided having the formula:
wherein R 1 is a de-hydroxyl or de-amino moiety respectively of a hydroxyl-bearing or amino-bearing biologically active molecule or an...
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7153940 |
C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly...
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7153875 |
Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
The invention relates to certain heterocyclic compounds useful for the treatment of cancer and other diseases, having the Formula (I):
wherein:
(a) m is an integer 0 or 1; (b) R 12 is...
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7153700 |
Methods and compositions for diagnosing and predicting the behavior of cancer
The present invention relates to methods for detecting the presence of SIX1 protein or nucleic acid in a biological sample in which a biological sample is contacted with an agent capable of...
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7153653 |
Differentially methylated sequences in pancreatic cancer
The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an...
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7153506 |
Use of anti-ferritin monoclonal antibodies in the treatment of some cancers
The invention concerns the use, in the preparation of a medicine for treating cancer whereof the cells exhibit overexpression of a product of a gene of the myc-related family, of an anti-ferritin...
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7151100 |
Indole compounds useful for the treatment of cancer
The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.
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7151099 |
Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases
Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer.
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7150869 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7148337 |
C-type LECTIN transmembrane antigen expressed in human prostate cancer and uses thereof
A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly...
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7148252 |
Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis
This invention relates to methods for using benzopyranones, or their pharmaceutically acceptable salts, for treating or preventing a primary brain cancer or a brain metastasis. The benzopyranones...
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7148201 |
Use of human plasma hyaluronidase in cancer treatment
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7148200 |
Method for treating cancer
A method for treating a cancer. The cancer excluding an adenocarcinoma and being epithelioma, glioma, sarcoma, melanoma, lymphoma or leukemia; or the cancer is an adenocarcinoma cancer excluding...
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7148038 |
Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof
Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung,...
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7148009 |
Cancer drug screen based on cell cycle uncoupling
Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a...
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7147848 |
Recombinant poliovirus for the treatment of cancer
The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are...
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7144912 |
Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression
The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder...
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7141576 |
Cancer treatment method
A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as pharmaceutical combinations and compositions...
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7138428 |
Compounds isolated from gamboge resin having activity in inhibiting the growth of tumor/cancer cells and pharmaceutical compositions comprising the same
Disclosed herein are an acetone-extracted product obtained from gamboge resin and compounds further purified from said acetone-extracted product, including a new compound called formoxanthone A....
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7138383 |
Treating cancer using an oligonucleotide N3′->N5′ thiophosphoramidate
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S − )O-5′ linkage, and methods of synthesizing and using the inventive...
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7135549 |
Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer
A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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