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10010552 Combination therapy comprising a CDK4/6 inhibitor and a PI3K inhibitor for use in the treatment of cancer  
A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.
10010542 PFKFB3 inhibit and methods of use as an anti-cancer therapeutic  
A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-pr op-2-en-1-one, is provided herein. (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-pr op-2-en-1-one is an...
10010520 Combined application of isothiocyanate compound and anti-cancer medicine  
The present invention relates to a combined application of isothiocyanate compounds and anti-cancer drugs, in particular to a composition, comprising: (A) a therapeutically effective amount of a...
10010504 Compositions and methods including celecoxib and plumbagin relating to treatment of cancer  
The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including celecoxib and...
10010277 Cancer detection by optical measurement of compression-induced transients  
A cancer screening method includes changing a compression state of selected tissue; and obtaining a signal indicative of a response of an optical property of the selected tissue in response to the...
RE46907 Suppression of cancer growth and metastasis using nordihydroguaiaretic acid derivatives with metabolic modulators  
Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two...
10006925 Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps  
Described herein are sets of metabolite and lipid (e.g., fatty acid) markers that can be used in the detection of early stage colorectal cancer and/or early development of adenomatous polyps....
10006092 Method to detect prostate cancer in a sample  
The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate...
10006091 Method for the diagnosis, prognosis and treatment of lung cancer metastasis  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in lung cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
10006032 Predictive biomarker for cancer therapy  
The present invention relates generally to the identification of patients suffering from cancer whether they will respond to specific therapies. More particularly the invention relates to a method...
10006029 Methods of treating colorectal cancer  
Disclosed herein are methods for treating/and or preventing colorectal cancer using a specific inhibitor of SMAD7 expression or function. Also disclosed are pharmaceutical compositions containing...
10005765 Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer  
Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or...
10005744 Compounds for the treatment or prevention of breast cancer  
It discloses compounds for the treatment and prevention of breast cancer, which are specifically 2-phenyl benzoselenazole compounds, pharmaceutically acceptable salts thereof and prodrugs thereof....
10004818 Ether and alkyl phospholipid compounds for treating cancer and imaging and detection of cancer  
Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
10004813 Constructs containing multiple expression cassettes for cancer therapy  
The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention...
10004809 Precise delivery of therapeutic agents to cell mitochondria for anti-cancer therapy  
Described is a targeted molecular scaffold for construction of a metabolic inhibitor loaded with cancer-cell specific activity and anti-tumor immunity. Incorporation of a mitochondria targeting...
10004776 Pharmaceutical composition for preventing or treating skin cancer comprising Panax spp. plant extract and method of preventing or treating skin cancer in a subject using the same  
Provided are a pharmaceutical composition for preventing or treating skin cancer and a method of preventing or treating skin cancer in a subject by using the pharmaceutical composition, wherein...
10004748 Methods of treating PR-positive, luminal A breast cancer with PI3K inhibitor, pictilisib  
Methods and compositions are provided for treating breast cancer in patients with a PI3K inhibitor, GDC-0941 in combination with an endocrine therapy agent.
10004742 Method of treating cancer  
Methods are provided of treating a human for cancer comprising administering at least one dose of lapatinib, or a pharmaceutically acceptable salt or composition thereof, to a patient, wherein...
10004739 Methods for treating cancer by inhibiting FGFR3/TACC3 fusion protein  
The present invention aims to elucidate a polynucleotide as a novel responsible gene for cancer and aims to thus provide a method for detecting the polynucleotide and a polypeptide encoded by the...
10004735 Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines  
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount a second active agent to a patient...
10004730 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer  
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a...
10004709 Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy  
Disclosed herein are methods for treating cancer comprising administering at least one immune checkpoint inhibitor and at least one Retinoic Acid Receptor or Retinoid X Receptor active agent.
10004708 Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy  
Disclosed herein are methods for treating cancer comprising administering at least one immune checkpoint inhibitor and at least one Retinoic Acid Receptor or Retinoid X Receptor active agent.
10004707 Method for treating cancer with low molecular weight components of aurin tricarboxylic acid complex  
A method of preventing and/or treating cancer in a subject is provided. The method includes administering to the subject a composition comprising an effective amount of an active agent selected...
10002426 System for cancer diagnosis  
Certain aspects of an apparatus and method for automatic ER/PR scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying a positive stained nucleus in a...
10001485 Methods for sensitizing a quiescent cancer stem cell to a BCR-ABL inhibitor  
The disclosure provides methods for determining the self-renewal potential of a cancer stem cell (CSC), or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting...
10001484 Reagents and methods for breast cancer detection  
The present invention provides compositions including reagents for detecting human autoantibodies against at least two proteins selected from the group consisting of ANGTPL4, DKK1, EPHA2, LAMC2,...
10000816 Method for detecting an increased risk of developing skin cancer and a use of a genotype variant of the GRHL3 gene  
The present invention is directed to methods of identifying SNP markers associated with skin cancers, and use of these markers to explain individual susceptibility to skin cancer development. In...
10000815 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments  
Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will...
10000813 Method of diagnosing and treating cancer using B-catenin splice variants  
The invention relates to method and compositions for treating and diagnosing cancer, in particular β-catenin related cancers. In general, the methods include administering RNAi constructs. The...
10000808 Methods of detecting cervical cancer  
Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of...
10000575 Targeting O-acetylated GD2 ganglioside as a new therapeutic and diagnostic strategy for cancer stem cells cancer  
An antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer, a pharmaceutical composition including the antibody for treating a CSC cancer and a...
10000568 Compositions and methods for detecting EGFR in cancer  
The invention discloses binding agents to the E746-A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including...
10000539 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10000505 Anti-cancer agents and preparation thereof  
Embodiments of the present invention provide, among other compounds, a family of spliceosome-inhibiting compounds that can be used as therapeutic anti-cancer agents. The compounds are synthesized...
10000449 Bisarylsulfonamides useful in the treatment of inflammation and cancer  
A compound of formula (I) useful for the treatment of cancer, inflammation and inflammatory disorders, and a pharmaceutical composition containing the compound.
9999760 DVDMS sensitizer for cancer sonodynamic therapy  
A method for treatment of hyperproliferative tissue by injection of and subsequently exposing the hyperproliferative tissue to a frequency of ultrasound. The invention further includes purified...
9999669 Pharmaceutical composition for intestinal cancer treatment and/or prevention  
A method for treatment and/or prevention of intestinal cancer is provided, and the method includes: administering a composition to a subject in need thereof, the composition comprising a...
9999655 Use of MKS inhibitor peptide-containing compositions for treating non-small cell lung cancer with same  
Pharmaceutical compositions, systems and methods for treating a non-small cell lung cancer (NSCLC) solid tumor comprising a population of tumor cells are described. In some aspects, administering...
9999620 CaMKK-β as a target for treating cancer  
Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a...
9999603 Compositions and methods including leelamine and arachidonyl trifluoromethyl ketone relating to treatment of cancer  
The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including...
9999598 Pharmaceutical composition for gastric cancer treatment and/or prevention  
A method for treatment and/or prevention of gastric cancer is provided, and the method includes: administering a composition to a subject in need thereof, the composition comprising a carbonaceous...
9995748 Biomarkers for prostate cancer comprising interleukin-8 (IL-8), tumor necrosis factor alpha and soluble tumor necrosis factor-alpha receptor 1  
The disclosure provides methods of using biomarkers to improve diagnosis of forms of prostate. The method includes testing a biological sample from an individual for a interleukin-8 (IL-8), Tumor...
9994912 Materials and methods for assessing progression of prostate cancer  
Methods of distinguishing and identifying a patient with aggressive/indolent, prostatic adenocarcinoma comprising contacting a sample from the patient with a set of detectably labeled probes under...
9994909 Diagnostic methods for determining prognosis of non-small cell lung cancer  
The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical...
9994907 Thyroid cancer diagnostics  
Disclosed herein, in certain instances, are methods for the diagnosis, prognosis and determination of cancer progression of a cancer in a subject. Further disclosed herein, in certain instances,...
9994900 Composite biomarkers for non-invasive screening, diagnosis and prognosis of colorectal cancer  
The present invention concerns particular biomarkers for diagnosing and/or prognosticating colorectal cancer, in particular in a non-invasive manner. The methods and compositions concern analysis...
9994843 Method for assaying microRNA, cancer therapeutic agent, and medicinal composition containing same for cancer therapy  
The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs...
9994554 Barbiturate and thiobarbiturate compounds for use in cancer therapy  
Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for...