Match Document Document Title
10322999 Oxindoles derivatives, preparation method thereof and pharmaceutical compositions for the prevention or treatment of cancer containing the same as an active ingredient  
The present invention relates to a novel oxindole derivative having anticancer activity, a preparation method thereof, and a method for treating cancer using the same. More specifically, the...
10322180 Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging  
The present invention provides a pharmaceutical composition containing hemoglobin-based therapeutic agent for treating cancer. The hemoglobin moiety can target cancer cells and the therapeutic...
10322149 Myxoma-treated graft material for cancer treatment  
A method of treating or preventing graft versus host disease (GVHD) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo...
10322145 Drug resistant immunotherapy for treatment of a cancer  
The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic...
10322136 Composition for inhibiting growth or proliferation of chronic myelogenous leukemia cancer stem cells, and screening method therefor  
Provided are a composition for inhibiting growth or proliferation of chronic myelogenous leukemia (CML) cancer stem cells, a pharmaceutical composition for preventing or treating CML, a method for...
10322123 Compound for anti-cancer therapy that acts by targeting GOF mutant P53 and stimulates P73 to restore the P53 pathway signaling  
The invention includes compositions comprising NSC59984 or a derivative or analog thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or...
10322113 Pharmaceutical compositions directly targeting FKBP52 for the treatment of prostate cancer and methods of using same  
Embodiments of the current invention include methods and compositions for regulating the activity of hormone receptors.
10322097 Treatment of subjects with multidrug-resistant cancer  
A quinonemethide triterpenoid is administered to subjects with multidrug-resistant cancer, in particular a cancer with enhanced expression and/or functional activity of ABC transporter proteins...
10317409 Glycosylation site-specific antibodies and anti-cancer compounds  
A method of characterizing the protein O-GlcNAcylation site-specificity of an antibody. A method of detecting or quantitating the expression of site-specific O-GlcNAcylated proteins expressed in...
10316367 Circulating miRNAs as markers for breast cancer  
The present invention is directed to methods for diagnosing breast cancer, metastasizing breast cancer, or for determining the CTC status in a subject. Moreover, the present invention is concerned...
10316361 Genome-wide methylation analysis and use to identify genes specific to breast cancer hormone receptor status and risk of recurrence  
To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis...
10316319 Composition for diagnosis of liver metastasis of colorectal cancer and the use thereof  
The present disclosure relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a composition for diagnosis of liver metastasis...
10316101 BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy  
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens,...
10316091 Cancer immunotherapy by disrupting PD-1/PD-L1 signaling  
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an...
10316090 Cancer immunotherapy by disrupting PD-1/PD-L1 signaling  
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an...
10316085 Therapeutic and diagnostic methods relating to cancer stem cells  
The present invention relates in part to the discovery of genes that are deregulated in cancer stem cells (e.g., melanoma stem cells). In some aspects, methods for treating individuals having...
10316065 Oncolytic adenoviruses for treating cancer  
The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass...
10316063 Immunotherapy against several tumors, such as lung cancer, including NSCLC  
A method of treating a patient who has glioblastoma and/or gastric cancer includes administering to said patient a composition containing a population of activated T cells that selectively...
10316062 Immunotherapy against several tumors, such as lung cancer, including NSCLC  
A method of treating a patient who has glioblastoma and/or gastric cancer includes administering to said patient a composition containing a population of activated T cells that selectively...
10316050 PT (IV) complexes containing 4,4′-disubstituted-2,2′-bipyridyl and their use in cancer therapy  
Platinum-containing compounds for the treatment of disease, such as, for example, cancer, are provided herein. Specifically, platinum Pt(IV) complexes with a substituted 2,2′-bipyridine ring...
10316038 Pyrrolopyrimidine ITK inhibitors for treating inflammation and cancer  
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein R1, R2, and X...
10316037 Compounds and methods for treating cancer  
The present invention is directed to novel anticancer compounds which show excellent activity as anticancer agents. The present invention is also directed to pharmaceutical compositions based upon...
10315055 Treatment of prostate cancer using enhanced energy application (EEA) in high intensity focused ultrasound (HIFU) procedures  
HIFU treatment of localized prostate cancer includes identifying the cancer locations in a patient's prostate and visually segmenting the patient's prostate into areas for analysis and treatment....
10314921 Antibody-drug-conjugate and its use for the treatment of cancer  
The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to a Target, said...
10314910 Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy  
Provided is a method for enhancing the potency of a targeted cancer immunotherapy in a subject by using a superantigen in combination with an immunopotentiator (for example, a PD-1 inhibitor).
10314905 Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-deltaC virus) in cancer therapy  
The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been...
10314903 Compositions and methods for treatment of cancer  
Here we show that SEG/SEI presented from a HLA-DQ8 (HLA-DQB*0302 and HLA-DQA*0301) platform prevent the de novo outgrowth (vaccination) of Lewis lung carcinoma (LLC) and B16-F10 melanoma and...
10314890 Combination therapy involving antibodies against claudin 18.2 for treatment of pancreatic cancer  
The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic...
10314870 Tropism modified cancer terminator virus (Ad.5/3 CTV;AD.5/3-CTV-M7)  
A tropism modified cancer terminator virus (Ad.5/3-CTV; Ad.5/3-CTV-M7) has been found to have infectivity that is Coxsackie Adenoviral Receptor (CAR) independent. The Ad.5/3-CTV (Ad.5/3-CTV-M7)...
10314866 Method of reducing the likelihood of skin cancer in an individual human being  
Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other...
10314865 Method and system for treating cancer and other age-related diseases by extending the healthspan of a human  
Various embodiments of the present invention are directed to the field of Oncology, and in particular, embodiments directed to a method of ameliorating, treating, or preventing a malignancy in a...
10314855 Methods relating to lung cancer  
The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by...
10314847 Scalarane sesterterpenoid, pharmaceutical composition and topoisomerase II and Hsp90 inhibitor for treating cancer, and use and preparation method thereof  
The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from Carteriospongia sp. sponge: where R1...
10314810 Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics  
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis....
10314551 Detector, three-dimensional direct positron imaging unit, and method to estimate the differential of the radiation dose provided to cancer cells and healthy tissues during hadrotherapy  
Disclosed is a detector for a positron imaging unit, comprises a hollow body with an inner cylindrical wall and an outer wall spaced apart from the inner cylindrical wall. The hollow body includes...
10309966 Personalized therapy of inflammation-associated cancer using methods of assessing the susceptibility of a subject to the treatment with EGFR inhibitors/antagonists  
The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR)...
10309957 Method for determining sensitivity to fluorouracil in a subject having colorectal cancer  
To provide a marker for determining sensitivity to an anti-cancer agent, which can determine whether or not a patient has a therapeutic response to the anti-cancer agent, and cancer therapeutic...
10308987 3.4 kb mitochondrial DNA deletion for use in the detection of cancer  
A method for detecting cancer in an individual comprising detecting a deletion in the nucleic acid sequence between residues 10743 and 14125 in mitochondrial DNA, obtaining a biological sample...
10308986 Cancer diagnosis, treatment selection and treatment  
The present invention provides assays, methods and systems for selecting an effective therapy for a subset of cancer patients having cancer cells with increased expression of BML and FANCI genes...
10308980 Methods and biomarkers for analysis of colorectal cancer  
The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool...
10308939 Use of an miRNA to reduce proliferation of a cancer cell  
A method is provided for decreasing at least one of the proliferation and the migration of a cancer cell comprising contacting a cancer cell with an effective amount of a pharmaceutically...
10308719 IL13Rα2 binding agents and use thereof in cancer treatment  
Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13Rα2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy...
10308717 Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor  
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII,...
10308714 Cancer immunotherapy by disrupting PD-1/PD-L1 signaling  
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an...
10308697 Fusion proteins for treating cancer and related methods  
Aspects of the disclosure provide fusion proteins that bind cells expressing one or more target molecules including, for example, one or more cell surface multisubunit signaling receptors (e.g.,...
10308663 Inhibitors of PTP4A3 for the treatment of cancer  
The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for...
10308631 Selective anti-cancer compounds  
A compound of formula I, wherein the compound of formula I has the structure: wherein R1 to R5, Y, L, Z and X1 to X7 have meanings given in the description, said compounds having utility in the...
10308596 HDAC8 inhibitors for treating cancer  
Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
10307489 Organic anion transporting peptide-based cancer imaging and therapy  
A dye-drug conjugate for preventing, treating, or imaging cancer having the following structure: wherein R1 and R2 are independently selected from the group consisting of —H, alkyl,...
10307412 Quinoline derivative against non-small cell lung cancer  
The present application provides a quinoline derivative against non-small cell lung cancer. 1-[[[4-(4-fluoro-2-methyl)-1H-indol-5-yl)oxy-6-methoxyquinol in-7-yl]oxy]methyl]cyclopropylamine or a...