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10563197 Use of a combination of Dbait molecule and PARP inhibitors to treat cancer  
The present invention relates to the combination of a PARP inhibitor with a Dbait molecule for treating cancer.
10562890 Cancer therapeutics  
This invention relates to compounds that bind to wild-type CBFβ and inhibit CBFβ binding to RUNX proteins. The potent compounds of the invention inhibit this protein-protein interaction at low...
10562886 Anti-cancer compounds  
This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these...
10562856 DNA2 inhibitors for cancer treatment  
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
10561747 Multifunctional cancer targeting nanoparticles  
Multifunctional cancer targeting nanoparticles include a magnetic central core including gold coated iron oxide, an outer layer including trimethyl chitosan microspheres and folic acid and a...
10561726 Methods of treating cancer using compositions of antibodies and carrier proteins with antibody pretreatment  
Described herein are methods, formulations and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes.
10561718 Peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10561717 Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer  
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and...
10561716 Prostate cancer vaccine  
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer....
10561712 Treatment of cancer and inhibition of metastasis using hemoglobin beta subunit  
The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The...
10561679 Double-stranded nucleic acid molecule, DNA, vector, cancer cell growth inhibitor, cancer cell migration inhibitor, and drug  
A double-stranded nucleic acid molecule for suppressing expression of non-coding RNA, the double-stranded nucleic acid molecule including: (a) a sense strand containing a nucleotide sequence...
10561676 Method for treating cancer using dual antagonists of CXCR1 and CXCR2  
What is described is a method for treating cancer in a patient in need of such treatment through the use of a dual CXCR1/2 antagonist by administering a therapeutically effective amount of a dual...
10561663 MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer  
A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that...
10561653 5-bromo-2,6-di-(1H-pyrazol-1-yl)pyrimidin-4-amine for use in the treatment of cancer  
The present invention relates to 5-bromo-2,6-di-(1H-pyrazol-1-yl)pyrimidin-4-amine, its pharmaceutically acceptable salts and co-crystals thereof and to pharmaceutical compositions comprising said...
10561652 Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer  
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
10561647 Use of quinoline derivatives for treating oesophageal cancer and treatment method, pharmaceutical composition and kit thereof  
Provided in the present invention are a use of quinoline derivatives for treating oesophageal cancer and a treatment method, a pharmaceutical composition and a kit thereof. The...
10557175 Method of predicting risk of recurrence of cancer  
A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least...
10556967 Anti-ADAM28 antibody for treating cancer  
The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that...
10556965 Methods and materials for treating cancer  
This document provides methods and materials related to treating cancer. For example, methods and materials for using particles (e.g., nanoparticles) containing (a) one or more molecules having...
10556964 Bispecific antibody-mediated cancer therapy with cytokine-induced killer cell  
Provided are compositions comprising a MSBODY and a cytotoxic immune cell (e.g., Cytokine-induced killer cell) to form Armed Activated CIK cells (ACCs), wherein the MSBODY comprising a first...
10556925 Compound, process for its preparation, a pharmaceutical solution containing the compound, a method of determining the presence of cancer, a kit for cancer detection, and the use of hydrolysis of the compound for the detection of cancer  
The subject of the invention is a new compound of the following chemical formula: ABZ1-Dap(O2(Cbz))2-Dap(O1)3-Dap(O2)4-Arg5-ANB6-NH2 where: ABZ stands for 2-aminobenzoic acid; DAP stands for...
10556875 Bis-diazeniumdiolate compounds as anti-cancer agents  
A series of double-component, bis O2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities...
10556010 Neoadjuvant therapy for bladder cancer  
This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In...
10555976 Method of reducing the likelihood of skin cancer in an individual human being  
Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other...
10555963 Klotho protein and related compounds for the treatment and diagnosis of cancer  
Disclosed is the use of a klotho protein or related compounds (especially KL1 or KL1 analogue) for treatment, and especially treatment of cancer, alone or together with other active pharmaceutical...
10555956 Chemoprevention of colorectal cancer  
In the present invention, a new combination is disclosed comprising (i) 5-aminosalicylic acid (5-ASA) or a derivative thereof, or a pharmacologically acceptable salt thereof, and (ii) a group D...
10555931 Pharmaceutical combination for the treatment of cancer  
The present invention relates to a pharmaceutical combination comprising a CDK inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention...
10555926 Use of cabazitaxel in the treatment of prostate cancer  
The present invention relates to cabazitaxel for use in a method for treating an AR-V7-positive patient suffering from prostate cancer comprising determining the AR-V7-status in said patient and...
D874652 Cover for cancer cell observation camera  
10551387 Cancer cell detection method using living body-derived cells  
A cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with...
10551385 Predicting cancer progression  
Method of determining a likelihood of cancer relapse in a subject who has completed cancer tumor surgery, radiotherapy treatment and/or chemotherapy treatment comprises contacting an antibody that...
10551383 Methods of detecting a polypeptide having anaplastic lymphoma kinase activity in kidney cancer  
The invention provides methods to identify, diagnose, and treat kidney cancer through the detection of expression and/or activity of anaplastic lymphoma kinase (ALK). The detection of the presence...
10550394 Anti-cancer RNA aptamers  
Provided herein, inter alia, are compounds capable of binding HSP70 (e.g. mHSP70) on a cell and internalizing into said cell. The compositions provided herein may be useful for delivering...
10550383 Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells  
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of...
10550377 Suppression of prostate cancer using a targeted clostridial neurotoxin  
The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer...
10550191 Method of treating cancer with an anti-CCR8 having antibody-dependent cell-mediated cytotoxicity (ADCC) activity against cells expressing CCR8  
The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.
10550186 Cancer therapy targeting intercellular adhesion molecule 4 (ICAM4)  
Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting ICAM4. While MDSCs in mice have been...
10550179 Compositions and methods for treating cancer with anti-mesothelin immunotherapy  
Chimeric antigen receptors containing mesothelin antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical...
10550167 Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10550114 Kinase inhibitors and their use in cancer therapy  
The present invention relates to a 2,3-diphenyl-1,6-naphthyridine-5-one derivative according to general formula (I), and the use of the 2,3-diphenyl-1,6-naphthyridine-5-one derivative in the...
10549124 Multiple beamline position isocenterless positively charged particle cancer therapy apparatus and method of use thereof  
The invention comprises a method and apparatus for treating a tumor with protons using multiple beamline positions not having an isocenter, including the steps of: (1) delivering the protons from...
10549082 Methods for cancer treatment  
Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the...
10548950 Irisin-related cancer treatments  
In one embodiment, the invention provides methods of treating or preventing cancer, in particular aspects breast and/or prostate cancer, by administering to a subject in need thereof a...
10548861 Use of ureidomustine (BO-1055) in cancer treatment  
Method of using ureidomustine (BO-1055), a water-soluble NDA cross-linking agent, in the treatment of a cancer, selected from the group consisting of various types of human leukemia [such as acute...
10548842 Nanoliposomal c-MYC-siRNA inhibits in vivo tumor growth of cisplatin-resistant ovarian cancer  
The present invention discloses c-MYC-siRNA formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-MYC with small interfering RNA (siRNA)...
10548761 Method and system for reducing the likelihood of colorectal cancer in a human being  
A system and method for reducing the likelihood of colorectal cancer in a human being includes the modification of an individual's gut microbes by employing a Clustered Regularly Interspaced Short...
10545154 Method for the absolute quantification of naturally processed HLA-restricted cancer peptides  
The present invention relates to a method for the absolute quantification of naturally processed HLA-restricted cancer peptides, i.e. the determination of the copy number of peptide(s) as...
10545150 Lung cancer molecular markers  
The invention provides a method of diagnosis and/or prognosis of lung cancer, the method comprising the steps of: (a) determining the level of a C4 activation fragment in a test sample, and (b)...
10545136 Methods for the monitoring and prognosis of a cancer  
The present invention relates to methods for prognosis and monitoring of a cancer, preferably bladder cancer, by measuring the proportion of CD8+ T Lymphocytes expressing ILT-2 and the plasma...
10545133 Molecular signatures of invasive cancer subpopulations  
Carcinomas typically invade as a cohesive multicellular unit, a process termed collective invasion. It remains unclear how different subpopulations of cancer cells contribute to this process. We...