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9918968 Rapamycin analogs targeting proteasome function in the treatment of cancer  
The invention provides for treatment of cancers using a rapamycin analog, optionally including bortezomib. In particular, the invention addresses the treatment of bortezomib-resistant cancers...
9918966 Anti-cancer compositions and methods  
Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject...
9918950 Targeted treatment of anerobic cancer  
The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in...
9915661 Composition, kit, and method for diagnosing and treating ovarian cancer  
Provided are a composition, a kit, and a method of predicting prognosis of ovarian cancer or a risk of recurrence of ovarian cancer. Provided are a composition for treating ovarian cancer or...
9915660 Methods for determining prognosis of colorectal cancer  
Provided herein are methods for determining the risk that a subject diagnosed with colorectal cancer will develop a recurrence of colorectal cancer and methods of predicting clinical outcome for a...
9914977 Individualized cancer therapy  
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal...
9914976 Methods and compositions for prostate cancer metastasis  
Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.
9914974 Molecular biomarker set for early detection of ovarian cancer  
Embodiments of the present invention concern methods and compositions related to detection of ovarian cancer, including detection of the stage of ovarian cancer, in some cases. In particular, the...
9914972 Methods for lung cancer classification  
The present invention provides specific nucleic acid sequences for use in the identification, classification and diagnosis of various sub-types of lung cancers. The present invention permits one...
9914775 Methods for treating inflammatory disorders or cancer metastasis by administering antibodies to connexin 43 (Cx43) hemichannels  
Methods for identifying compounds that positively regulate connexin 43 hemichannels.
9914768 Anti-S100A7 antibodies for the treatment and diagnosis of cancer  
The present invention relates to the use of antibodies against S100A7 protein for the prevention and/or treatment of cancer or a disease associated to an undesired angiogenesis or a disease...
9914752 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
9913846 Combination of a PI3 kinase inhibitor with pacitaxel for use in the treatment or prevention of a cancer of the head and neck  
A pharmaceutical combination comprising (a) a phosphatidylinositol-3-kinase (PI3K) inhibitor compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof and (b)...
9913838 Methods of treating cancer using compositions comprising perillyl alcohol derivative  
A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH. The brain...
9913816 Method for applying metformin and sodium butyrate in K-ras mutation cancer treatment  
A method for using metformin and sodium butyrate in combination to treat a cancer patient with K-ras mutation is disclosed. When administering the pharmaceutical composition to a cancer patient,...
9913811 Hydroxynaphthoquinone compounds for treatment of non-small cell lung cancer  
A compound suitable for treating EGFR-dependent non-small cell lung cancer exceptionally inhibits activity of the EGFR kinase, in particular in EGFR-dependent non-small cell lung cancer with...
9913809 Anti-cancer activity of (E)-1-(3′,4′-dimethoxyphenyl) butadiene  
The present invention provides a method of using (E)-1-(3′, 4′-dimethoxyphenyl) butadiene to induce anti-tumorigenic effects in pancreatic carcinoma, ovarian carcinoma, prostate carcinoma, colon...
9909190 Method for assisting detection of pancreatic cancer  
Disclosed is the provision of a method for assisting the detection of pancreatic cancer, the method assisting the detection of pancreatic cancer with high accuracy. In the method for assisting the...
9909186 Personalized biomarkers for cancer  
The invention provides methods and reagents for identifying personalized tumor biomarkers for a patient that has a solid tumor and methods of using such biomarkers to monitor patient responses to...
9909185 Diagnosis and prognosis of breast cancer patients  
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
9909128 Splice modulating oligonucleotides that inhibit cancer  
A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit...
9908922 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
9908920 Peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
9907849 Combination of a PD-1 antagonist and a listeria-based vaccine for treating prostate cancer  
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Listeria based strain that expresses prostate-tissue specific antigen...
9907842 Cytotoxic T lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer  
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as lung carcinoma. The invention discloses peptides,...
9907800 Kinase inhibitors and method of treating cancer  
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase...
9907798 Methods of treating head and neck cancer  
Methods of treating a head and neck cancer are disclosed.
9907768 Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy  
Disclosed herein are methods for treating cancer comprising administering at least one immune checkpoint inhibitor and at least one Retinoic Acid Receptor or Retinoid X Receptor active agent.
9903878 Biomarker for human prostate cancer  
A method of diagnosing the presence of cancer in a subject without the need for a biopsy is provided. The method comprises obtaining a bio-sample from the subject and then extracting lipids from...
9903872 Identification of protein associated with hepatocellular carcinoma, gliobastoma and lung cancer  
The present invention provides methods and compositions for screening, diagnosis and prognosis of HCC, glioblastoma and lung cancer, for monitoring the effectiveness of HCC, glioblastoma and lung...
9903870 Methods and compositions for the diagnosis of ovarian cancer  
A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular...
9903867 Methods for predicting and improving the survival of colorectal cancer patients  
The present invention provides assays and methods for predicting the survival of a subject having colorectal cancer (CRC), thereby determining whether the subject will have a good prognosis or...
9903000 Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein  
A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the...
9902998 Non-invasive diagnostic method for diagnosing bladder cancer  
Non-invasive diagnostic methods for diagnosing bladder cancer are based on determining the expression level of one or more markers. The one of the markers comprises the IGF2 gene in a sample from...
9902778 Cancer therapy using CLDN6 target-directed antibodies in vivo  
The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6....
9901583 Method of treating non-small cell lung cancer and/or small cell lung cancer using thienotriazolodiazepine compounds  
A method of treating non-small cell lung cancer and/or small cell lung cancer in a mammal comprises the step of administering to a patient a pharmaceutical acceptable amount of a compound being a...
9901578 Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer  
The present invention relates to compositions comprising a combination of 10-propargyl-10-deazaaminopterin and an EGFR Kinase inhibitor, including erlotinib, for treatment of non-small cell lung...
9901570 Breast cancer cell growth-inhibiting enzyme inhibitors, method for the production thereof, and use thereof  
Novel enzyme inhibitors for treatment of breast cancer combine the inhibition of enzymes that combat aggressive breast cell growth both synergistically and additively. Pyrido-annulated indoles...
9901542 Methods of treatment of cancer by continuous infusion of coenzyme Q10  
The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination...
9901081 Transgenic mouse for determining the role of senescent cells in cancer  
This invention provides a transgenic mouse with a p16INK4a promoter sequence that controls expression of a protein such that it is expressed preferentially in senescent cells. The protein either...
9898817 Software tool for breast cancer screening  
What is disclosed is a software tool which enables medical practitioners to manually or automatically analyze a thermal image of an area of breast tissue for the presence of tumorous tissue. In...
9897608 Detection of ovarian cancer using antibody arrays  
Disclosed are antibody arrays for the detection of cancer in a human or animal subject, comprising a solid support having disposed thereon in a predetermined spatial configuration, a panel of...
9897607 Methods, kits, and systems for treatment of metastatic papillary thyroid cancer  
Provided herein are methods for identifying a subject with an increased likelihood of developing or having metastatic papillary thyroid cancer (PTC), or a subject with an increased likelihood of...
9896732 Method of diagnosing cancer comprising detection of the methylation signature in the hTERT promoter  
A method of diagnosing cancer in a mammal is provided. The method includes the steps of determining in a nucleic acid-containing sample from the mammal the degree of DNA methylation of a target...
9896730 Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment  
The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase...
9896445 Heterocyclic inhibitors of ERK1 and ERK2 and their use in the treatment of cancer  
The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful for...
9896420 N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation  
The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear...
9895441 Methods of treating cancer using PD-L1 axis binding antagonists and VEGF antagonists  
The present invention describes combination treatment comprising a PD-1 axis binding antagonist, chemotherapy and optionally a VEGF antagonist and methods for use thereof, including methods of...
9895438 Treatment of cancer with naltrexone  
The present invention provides novel therapeutic applications of low dose naltrexone (LDN). Said applications have been determined in light of the discovery by the present inventors that...
9895430 Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer  
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and...