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7541142 |
Pancreatic cancer genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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7541141 |
Method of using estrogen-related receptor alpha (ERRα) status to determine prognosis, treatment strategy and predisposition to breast cancer, and method of using ERRα as a therapeutic target for the treatment of breast cancer
The present invention provides that ERRα is a breast cancer biomarker of clinical course and treatment sensitivity and, itself, a target for breast cancer treatment. A high ERRα level in breast...
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7541035 |
Immunogenic peptides for the treatment of prostate and breast cancer
Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino...
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7537923 |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or...
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7537913 |
High throughput assay for cancer cell growth inhibition
A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media...
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7537905 |
Amplified and overexpressed gene in colorectal cancers
This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a...
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7534878 |
Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of...
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7534817 |
Kombic acid/sarganol bis-succinate and derivatives as potent apoptogens (antineoplastic agents) with high selectivity for cancer cells
This invention provides sarganol bis-succinate and alkyl and aryl derivatives thereof as potent apoptogens (antineoplastic agents) with high selectivity for cancer cells.
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7534772 |
Methods for enhancing antibody-induced cell lysis and treating cancer
The invention relates to methods and products for treating cancer. In particular the invention relates to combinations of nucleic acids and antibodies for the treatment and prevention of cancer....
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7534575 |
Method for detecting cancer using an antibody to Zcytor16
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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7534565 |
DLC-1 gene deleted in cancers
A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the...
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7534443 |
Preparations for immunotherapy for cancer having bacterial somatic constituent as the active ingredient
An oil-in-water emulsion that comprise a bacterial component as an active ingredient as well as essentially an oil, surfactant, and a stabilizer, and that can be used as an agent for immunotherapy,...
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7534417 |
103P2D6: tissue specific protein highly expressed in various cancers
A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence...
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7531695 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic...
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7531634 |
Bladder matrix protein peptides and methods of detection of bladder cancer
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell...
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7531578 |
Compounds and methods for treating breast cancer and other diseases
Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety...
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7531562 |
Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy
Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course...
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7531517 |
Inhibitors of cancer cell, T-cell and keratinocyte proliferation
The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof,
wherein
Y is —NR a R b , —NR c C═ONR a R b, —NR c C═SNR a...
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7531300 |
Method of diagnosing breast cancer
Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene...
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7528243 |
Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer
Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these...
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7528152 |
Hemiasterlin derivatives and uses thereof in the treatment of cancer
The present invention provides compounds having formula (I):
and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein...
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7528141 |
Use of cyclopenta[g]quinazoline derivatives for treating cancer
Method for aiding regression and palliation of a solid tumor in a patient in need of such treatment, comprising administering to the patient an effective amount of a cyclopenta[g]quinazoline of the...
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7528125 |
Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer
Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator...
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7527812 |
Herbal composition for treating cancer
An herbal composition that provides anti-cancer effects, especially for breast cancer.
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7527792 |
Pharmaceutical composition comprising an anti-cancer and at least a peptide
The invention concerns a pharmaceutical composition for treating and/or preventing cancer comprising at least an anti-cancer agent, characterised in that said anticancer agent is associated in the...
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7527786 |
Methods for inhibiting the growth of cancer cells expressing PSCA
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade...
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7526387 |
Expression profile algorithm and test for cancer prognosis
The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs...
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7525011 |
Transgenic cancer models in fish
The present invention provides transgenic fish whose genome has stably-integrated therein an oncogene operably linked to a promoter. Methods of making the transgenic fish and methods for their use...
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7524872 |
Method and composition for treating cancer using cellular organelle crystallizing agents
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
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7524634 |
MN/CA IX and cancer prognosis
Herein disclosed are methods that are prognostic for neoplastic/preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which...
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7524633 |
Method of detection of prostate cancer
The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate...
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7524498 |
Human immunomodulatory monoclonal antibodies for the treatment of cancer
The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
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7522825 |
Method and device for skin cancer screening
A method for providing a preliminary diagnosis of skin cancer, more specifically a screening risk assessment of pigmented lesions receiving digital photographs of skin abnormalities from a...
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7521205 |
Genes and polypeptides relating to prostate cancers
The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as...
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7521065 |
Compositions for the treatment and prevention of cancer
Compositions are provided for the topical treatment of cancer consisting of lotions, creams, sprays, suppositories or slow-release transdermal patches containing lipid-soluble, skin-penetrating...
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7517986 |
Tetrahydropyridothiophenes for use in the treatment of cancer
Compounds of the formula (I)
in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
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7517952 |
Compositions and methods for the therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7517650 |
Method of diagnosing breast cancer and compositions therefor
A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a...
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7514570 |
Derivatives of 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazole as antagonists of the gonadotropin releasing hormone (GnRH) for use in the treatment of sex hormone related conditions, such as prostatic of uterine cancer
The invention relates to a group of novel pyrazole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , M and R 5 are as defined in the specification, which are useful as gonadotrophin releasing...
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7514463 |
Lonidamine analogues and their use in male contraception and cancer treatment
Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.
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7514413 |
In-vivo energy depleting strategies for killing drug-resistant cancer cells
This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to,...
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7514231 |
Anti-aurora-A monoclonal antibody, method for obtaining same and uses thereof for diagnosing and treating cancers
The invention concerns a monoclonal antibody directed against mammalian aurora-A kinase, the method for obtaining same, as we ll as its uses in cancer diagnosis and prognosis, and in pharmaceutical...
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7514209 |
Diagnosis and prognosis of breast cancer patients
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
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7514207 |
Methods of screening for compounds that decrease phosphorylation of merlin and may be useful in cancer treatment
The present inventions features methods for treating or preventing cancer (e.g., cancer of the central nervous system) by administering a compound that inhibits PAK kinase activity and/or merlin...
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7514078 |
Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or...
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7514066 |
Targeted combination immunotherapy of cancer and infectious diseases
The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities,...
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7510868 |
Chimeric adenoviruses for use in cancer treatment
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
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7510855 |
84P2A9: a prostate and testis specific protein highly expressed in prostate cancer
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple...
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7510842 |
Biomarker for ovarian and endometrial cancer: hepcidin
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In...
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7510835 |
Methods for identifying risk of breast cancer and treatments thereof
Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying...
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