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10045698 Apparatus and method for detecting a presence of cancer  
A diagnostic apparatus (20) for detecting a presence of breast cancer in a patient disposed in a testing position. The diagnostic apparatus (20) includes a housing (44) and a camera assembly (58)...
10042983 Apparatus for cancer diagnosis  
The present invention provides an apparatus for screening cancer, which reads low-mass ion mass spectrum for diagnosing cancer based on biostatistical analysis with respect to low-mass ions...
10042977 Method utilizing repeat PSA screening for diagnosis of virulent prostate cancer  
A method for detecting aggressive prostate cancer is described, for instance for use in determination of the need for biopsy based. Disclosed methods recognize the difference in PSA rate of change...
10041948 Materials and methods for determining cancer risk  
This document relates to materials and methods involved in assessing inflammatory bowel disease patients at risk for developing cancer. For example, materials and methods for monitoring colorectal...
10041938 Measuring a level of a 5-hydroxymethylcytosine in a sample from a subject having a cancer or suspected of having cancer  
Provided herein are methods and kits for measuring a level of a 5-hydroxymethylcytosine in a nucleotide sequence from a subject, wherein the subject is a subject having a cancer or suspected of...
10041933 Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy  
The present invention relates to modulators of the interaction of astrin and raptor, and their uses in the treatment of mTOR related diseases, such as cancer.
10041129 Immune gene signatures in cancer  
This invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects with cancer, such as colorectal cancer, based on tumor expression levels of...
10041126 Monocyte biomarkers for cancer detection  
The disclosure relates to the field of biomarkers to diagnose a disease, more particularly to the field of biomarkers to diagnose cancer, and most particularly to colorectal cancer. Specifically,...
10041124 Methylation biomarkers for ovarian cancer  
Different combinations of methylation status based biomarkers can be used to test for ovarian cancer with high sensitivity and high specificity.
10041123 Recurrent gene fusions in prostate cancer  
Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer...
10040853 Methods and compositions involving NKG2D inhibitors and cancer  
Embodiments methods and compositions involving inhibitors of the immunoreceptor Natural Killer Group 2, Member D, (NKG2D) for inhibiting tumor progression and treating cancer.
10040846 Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer  
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane...
10040789 1,3,4-thiadiazole compounds and their use in treating cancer  
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6...
10040788 1,3,4-thiadiazole compounds and their use in treating cancer  
The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R1 and R2 have any of the meanings defined herein. The specification also relates...
10039846 Compositions targeting bradykinin receptor B1 for medical imaging of cancer and other disorders  
Bradykinin B1 receptor (B1R) targeting peptides and compounds are radiolabelled with radioisotopes that are suitable for imaging and/or radiotherapy. The radiolabelled peptides and compounds have...
10039796 Mutant herpes simplex virus-2 for cancer therapy  
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic...
10039771 Method for cancer cell reprogramming  
In one embodiment, the invention provides a method of inhibiting cAMP efflux and increasing intracellular cAMP in a subject who suffers from, or who is at risk of developing, a cancer by...
10039764 Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression  
Disclosed are methods for treating cancer and precancerous conditions with PDE10A specific inhibitors and diagnosis of neoplastic diseases based on elevated levels of PDE10A.
10039752 Methazolamide for the treatment of cancer  
The present invention relates to methods of using methazolamide to treat pancreatic cancer. Pancreatic cancer can be treated by administering to a patient in need thereof an effective amount of...
10039731 Treatment of cancer with specific RXR agonists  
A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating threshold and at or above the RXR...
10039725 Method for treating non-melanoma skin cancer by inducing UDP-glucuronosyltransferase activity using pterostilbene  
A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the...
10039716 Liposomal cisplatin compositions for cancer therapy  
The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of...
10036752 Agents and methods for determining colorectal cancer status  
The invention provides a method of determining the colorectal cancer status of subject, comprising applying to a colon and/or rectal surface an agent which is able to distinguish between a) mature...
10035009 Systems and methods for treating pancreatic cancer  
A method of treating pancreatic cancer includes: inserting a device into a stomach or a duodenum; securing at least a portion of the device in position relative to the stomach or the duodenum; and...
10034939 Synergistic combination of immunologic inhibitors for the treatment of cancer  
In some embodiments, the methods involve the use of a combination of at least two of the following: an inhibitor of indoleamine-2,3-dioxygenase (IDO), an inhibitor of the PD-L1/PD-1 pathway, an...
10034926 Use of toll-like receptor agonist for treating cancer  
The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present...
10034903 Bacterium-based microrobot capable of targeting cancer tissue  
To provide a bacterium-based microrobot which can be specifically targeted to cancer in vivo, the present invention provides a drug delivery system for cancer tissue, comprising a bacterium, and a...
10034901 Cancer immunotherapy  
Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.
10034895 Local application of D-lactic acid dimer is selectively cytotoxic when applied to cancer cells  
At equimolar concentrations, D-lactic acid dimer is more cytotoxic than L-lactic acid when directly applied to human HeLa cells in culture. The cytotoxicity of D-lactic acid dimer is an...
10034860 Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer  
Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
10030271 Gene expression profile associated with prostate cancer  
Using an RT-PCR platform, detection of gene transcripts highly expressed in prostate tissue and expressed in peripheral blood mononuclear cells (PBMC) from patients with mCRPC can provide a more...
10030269 Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism  
The present invention relates to the discovery that the modulation of particular microRNAs can be employed to inhibit a mesenchymal transition that, in certain instances, correlates with...
10030227 Canine autologous immunotherapy using dendritic cell induced cancer killing immunocytes  
Described are compositions of matter, protocols, and treatment means for induction of immune mediated killing in dogs suffering from cancer. The invention provides means of extracting peripheral...
10030074 Methods of inducing or enhancing an immune response in a subject having cancer by administering GITR antibodies  
The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by...
10030044 Nucleotides for the treatment of liver cancer  
Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments,...
10030039 Anti-cancer agent and cancer cell killing method  
[Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a complex produced by making a metal-salen...
10030036 Method and dyes for detecting and destroying cancer cells  
This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer...
10029991 Modulators of development of adipocyte and cancer cells  
One aspect of the disclosure relates to derivatives of aryl and heterocyclic ureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea, curcumin, and...
10029956 Therapies for cancer using isotopically substituted lysine  
Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.
10029124 Multiple beamline position isocenterless positively charged particle cancer therapy apparatus and method of use thereof  
The invention comprises a method and apparatus for treating a tumor with protons using multiple beamline positions not having an isocenter, including the steps of: (1) delivering the protons from...
10029003 Methods and materials for treating cancer  
This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well...
10028997 Systems and methods for attracting and trapping brain cancer cells  
Described herein are systems and methods for attracting and trapping cancer cells at a specific site where focal radiation and/or surgical resection and/or chemotherapeutics can eliminate them.
10028989 Composition comprising Retinol, a precursor or a reaction product of it and a plant extract from at least one Chamomilla plant for the treatment of cancer  
The invention relates to a (i) Vitamin A, a reaction product, a metabolite or a precursor of it and (ii) a plant extract of chamomile or an active component thereof, preferably for use in the...
10028958 Methods of treating cancer with a combination of selected MEK1/2 and AXL inhibitors  
Methods, compounds and kits relating to treating cancer, reducing kinase inhibitor or resistance, and reducing or preventing diminished ectodomain shedding are described.
10028911 Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent  
Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form...
10024860 Cancer-related extracellular matrix signatures and related methods and products  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
10024859 Markers for detection of gastric cancer  
Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric...
10024857 Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis  
Biomarkers of pancreatic cancer are described, as well as methods using these compounds for detecting pancreatic cancer. The methods can be used to diagnose a patient's health state, or change in...
10023916 Markers of tumor cell response to anti-cancer therapy  
Compositions and methods for determining circulating biomolecules before, during, and/or after treatment of a patient with an anti-cancer or anti-tumor drug (or putative drug) are described....
10023915 Method for screening for a cancer treatment agent using the interaction between PAUF and a binding partner thereof  
The present invention relates to a method for screening for a cancer treatment agent by contacting a test material with pancreatic adenocarcinoma upregulated factor (PAUF) and GLRX3, SNAPIN, or...