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7595149 |
Methods for cancer detection
A method is provided for detecting an analyte indicative of a cancer or a metastatic disease condition, which utilizes the ability of the analyte to induce permeability in a barrier. The method...
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7595048 |
Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of the immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them,...
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7595046 |
Treatment of cancer using anti-Apo-2 antibodies
Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also...
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7592441 |
Liver cancer-related nucleic acids
Described herein are novel polynucleotides associated with liver cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that...
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7592367 |
Compounds from Garcinia hanburyi, their use in treating cancer and method of separating epimers thereof
Three pairs of C-2 epimeric xanthones isolated from Garcinia hanburyi and method for efficiently separating the xanthone compounds into individual epimers, each of which possesses varying...
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7592320 |
Cancer gene therapy based on translational control of a suicide gene
A novel gene therapy for cancer has been discovered, which unlike most prior approaches, does not require specific knowledge of the cancer cells, but instead targets a general characteristic that...
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7592149 |
Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer
A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7592145 |
Pin 1 as a marker for prostate cancer
This invention provides methods for diagnosing prostate cancer, methods for measuring the aggressiveness of prostate cancer, and methods for identifying prostate cancer likely to metastasize. The...
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7592137 |
Genetic testing kits and a method of bladder cancer
A deletion in the end region of the long arm of a Chromosome 9 is efficiently detected. A genetic testing kit of bladder cancer according to the present invention includes a primer allowing for...
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7589239 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to novel compounds according to formula (I) wherein R 1 , R 2 , and X are as defined herein. The invention also discloses methods of preparation, pharmaceutical...
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7589173 |
Methods for diagnosing cancer and decreasing metastasis by cancer cells
The invention provides a protein that is a tumor marker protein. This protein can be used to prepare antibodies that bind to the tumor marker protein. These antibodies can be used to reduce, or...
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7589119 |
Methods for treating or preventing metastatic cancer using benzopyranone compounds
This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or...
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7589069 |
Replication-competent anti-cancer vectors
Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to...
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7589062 |
Two synthetic peptides for treatment and prevention of cancers
Two synthetic peptides, Atroporin (AT) and Kaotree (KT), each consisting of ten amino acids and their use for the treatment and/or prevention of various types of cancers is disclosed. The amino...
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7588904 |
Perinucleolar compartment as a cancer marker
The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention...
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7588895 |
Biomarkers for oral tongue cancer metastasis and extracapsular spread (ECS)
The present invention provides for the first time molecular diagnostic and prognostic markers for tongue cancer metastasis and extracapsular spread that are independent of histopathological...
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7588894 |
Use of ID4 for diagnosis and treatment of cancer
Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and...
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7585945 |
Use of recombinant heat shock protein complexed to kidney cancer antigen
A heat shock protein in combination with carbonic anhydrase IX and a method for improving immune response to carbonic anhydrase IX in a mammal by complexing it with a heat shock protein prior to...
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7585893 |
Anti-cancer composition comprising DMXAA or related compound
The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein...
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7585864 |
Farnesyl protein transferase inhibitors and their use to treat cancer
Disclosed are compounds of the formula:
wherein R 8 represents a cyclic and acyclic moiety to which is bound an imidazolylalkyl group; R 9 represents a carbamate, urea, amide or sulfonamide...
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7585634 |
Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same
Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a...
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7585506 |
Compositions and methods for the therapy and diagnosis of lung cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic...
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7585505 |
Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in...
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7582736 |
Prostate cancer specific internalizing human antibodies
This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The...
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7582668 |
Imidazoyl-benzamide anti-cancer agents
Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
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7582623 |
Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and...
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7582614 |
Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection
The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive...
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7582448 |
84P2A9: a prostate and testis specific protein highly expressed in prostate cancer
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple...
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7582287 |
Method for treating cervical cancer
Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or...
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7579503 |
BIS (thio-hydrazide amide) salts for treatment of cancers
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):
Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R 1...
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7579452 |
Cancer vaccine based on brother of regulator of imprinted sites molecule
Polynucleotides encoding a nonfunctional mutant form of the Brother of Regulator of Imprinted Sites (BORIS) molecule, nonfunctional mutated BORIS protein, polypeptide or peptide and modified...
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7579434 |
Peptide having ability to activate cancer-related gene
To provide a cancer diagnostic reagent for determining malignancy of a cancer patient or a cancer cell and a tendency of canceration of a healthy subject, the reagent including a peptide having an...
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7579433 |
Methods and compositions for treatment of arthritis and cancer
The present invention provides a new 18-residue homodimerized peptide, designated PIP [59-67] dimer (SEQ ID NO: 1), which is a mutant of the optimized anti-inflammatory peptide P-NT.II, the patent...
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7579349 |
4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer
A compound of Formula (I); wherein the substituents are as defined in the text for use in modulating insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
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7579330 |
Methods of treating various cancers using melanoma differentiation associated protein-7
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
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7579314 |
Use of RGD-enriched gelatine-like proteins for inhibition of cancer metastasis
The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD...
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7579160 |
Methods for the detection of cervical cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic...
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7579158 |
Cellular retinoic acid binding protein II as a marker for breast cancer
The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method...
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7579152 |
SENP1 as a marker of cancer development and target for cancer therapy
The present invention relates to compositions and methods for the use of SENP1 as a marker for cancer diagnosis, specifically prostate cancer. Still further, it relates to the use of inhibitors of...
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7579147 |
Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least...
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7575928 |
Genes for diagnosing colorectal cancer
This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of...
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7575926 |
Method of identification of compounds effective against suppressed cancer cells
A method for identifying compounds capable of targeting suppressed cancer cells, the method including the steps of comparing the response to a test compound of cancer cells grown on a suppressing...
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7575749 |
Serpentine transmembrane antigens expressed in human cancers and uses thereof
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
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7572923 |
Indirubin derivatives having anticancer property against human cancer cell line
The present invention relates to an indirubin derivative having anticancer property by inhibiting cell proliferation as to human cancer cell line. More particularly, this invention provides the...
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7572887 |
Gene expressed in prostate cancer, methods and use thereof
A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also...
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7572814 |
3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds
Certain 3,5-dibenzoyl-4-phenyl-piperidine compounds and salts thereof are provided herein. The compounds and salts may be useful in causing mitotic arrest and cell death. Also provided herein are...
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7572448 |
Combined cancer treatment methods using selected antibodies to aminophospholipids
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7570063 |
Space-time microwave imaging for cancer detection
Microwave imaging via space-time beamforming is carried out by transmitting microwave signals from multiple antenna locations into an individual to be examined and receiving the backscattered...
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7569711 |
Enone cancer therapeutics
Described herein are new enone derivatives and conjugates. Additionally, methods for synthesizing these new enones are also disclosed. These compounds can be employed in cancer therapy.
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