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10201521 Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem and cancer stem cells including glioblastoma multiforme and medulloblastoma  
The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that...
10197563 3-D in vitro model for breast cancer dormancy  
Disclosed is a three-dimensional (3-D) in vitro model for studying and subsequently treating cancer dormancy. The model is specifically useful in studying breast cancer and may be used for drug...
10196698 DNA methylation markers for metastatic prostate cancer  
The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment,...
10196697 Prostate cancer classification  
A method is provided for characterizing and/or prognosing prostate cancer in a subject comprising determining the expression level of at least one of CREM, ERRFI1, SRSF5, PDK4, HJURP, PDRG1,...
10196696 RNA-biomarkers for diagnosis of prostate cancer  
The invention relates to the identification and selection of differentially expressed transcripts (biomarker) in tumour cells. Specific determination of the level of these biomarkers can be used...
10196695 RNA-biomarkers for diagnosis of prostate cancer  
The invention relates to the identification and selection of differentially expressed transcripts (biomarker) in tumour cells. Specific determination of the level of these biomarkers can be used...
10196694 Method for analyzing PSA, and a method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing PSA  
A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved...
10196693 Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer  
Methods for treating triple negative breast cancer with an androgen receptor inhibitor are provided, as well as methods for screening for the likelihood of the effectiveness of such treatment.
10196691 Colon cancer gene expression signatures and methods of use  
A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful...
10196687 Molecular diagnosis and typing of lung cancer variants  
Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample at...
10196447 Anti-vascular endothelial growth factor receptor 2 (VEGFR2) antibody and methods of use thereof for detecting VEGFR2 and for inhibiting tumor growth, tumor angiogenesis and/or inducing cancer cell cytotoxicity  
An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor...
10196442 Methods of inhibiting growth of a colon cancer tumor in a subject by administering monoclonal antibodies to G protein-coupled receptor 49 (GPR49)  
Described herein are antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines...
10196382 bis-Pyridazine compounds and their use in treating cancer  
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, where R1 can be hydro, methoxy, difluoromethoxy or trifluoromethoxy; R2 can be hydro, methoxy, trifluoromethoxy or...
10195466 Method for treating skin cancer using radiation therapy  
The described invention provides methods for irradiating skin cancer cells, such as melanoma cells, at a high radiation rate (e.g., of 2,400 mu/min) and a modest total dose (e.g., of 0.5 Gy) to...
10195459 Device for photodynamical therapy of cancer  
A method and device for photodynamic therapy for treating cancer. The method includes: providing a photodynamic therapeutic device for treating cancer. The provided device includes a plurality of...
10195297 Iron garnet nanoparticles for cancer radiotherapy and chemotherapy  
Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron...
10195285 AGTR1 aptamer-anticancer drug complex for cancer cell chemotherapy  
This invention relates to a complex for cancer cell chemotherapy and, more particularly, to an AGTR1 aptamer-anticancer drug complex for chemotherapy of cancer cells, which includes a nucleic acid...
10195259 Compositions and methods for treatment of cancer using bacteria  
Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for...
10195258 Tape preparation of WT1 peptide cancer vaccine for transdermal administration  
The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support,an adhesive layer comprising an adhesive disposed on one side of the support,...
10195238 Composition for inhibiting renal cancer cell growth and enhancing kidney function  
The present invention provides a composition for inhibiting renal cancer cell growth and enhancing kidney function. This composition is constituted of water-soluble base material,...
10195219 Cancer therapy  
The present invention is directed to compositions and methods for the treatment of cancers, particularly cancers of epithelial origin. Therapy with a plurality of nutraceutical,...
10195188 Method of treating pancreatic cancer  
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients...
10195182 ITE for cancer intervention and eradication  
A method of cancer intervention or eradication by administering an effective amount of an endogenous ligand for the aryl hydrocarbon (Ah) receptor (AhR) named ITE or one of its analogs (the active...
10195175 Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors  
The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, such as microtubule inhibitors and/or PARP inhibitors. Where ADCs are...
10195164 Use of disulfiram for inflammatory breast cancer therapy  
Methods, compositions of matter, and kits for treatment of breast cancer, and in particular for inflammatory breast cancer, in a patient are disclosed. The methods can include administering a...
10194833 Method and apparatus for non-invasive detection of conditions such as lung cancer  
A method of determining whether a subject is likely to have a condition includes measuring concentration levels of a plurality of target biomarkers in a sample obtained from the subject; comparing...
10194825 Methods and apparatuses for the localization and treatment of disease such as cancer  
Embodiments of the present invention provide methods of detecting disease, methods of treating disease using targeted hyperthermia, methods of treating disease using targeted chemical agents,...
10192099 Systems and methods for automated screening and prognosis of cancer from whole-slide biopsy images  
Systems and methods for detection, grading, scoring and tele-screening of cancerous lesions are described. A complete scheme for automated quantitative analysis and assessment of human and animal...
10192027 Systems and methods for RNA analysis in functional confirmation of cancer mutations  
Contemplated systems and methods integrate genomic/exomic data with transcriptomic data by correlating a cancer associated mutation in the genome/exome with the transcription level of the affected...
10191059 In vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method  
The present invention relates to the prognosis of the outcome of a cancer in a patient, which prognosis is based on the quantification of one or several biological markers that are indicative of...
10191058 Diagnosis of cancer by detecting auto-antibodies against vascular endothelial growth factor receptor (VEGFR)  
The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor receptor (VEGFR) in...
10191057 Methods of diagnosing, classifying and treating endometrial cancer and precancer  
Diagnostic and therapeutic applications for endometrial cancer are described. The diagnostic and therapeutic applications are based on certain activation mutations in the FGFR2 gene and its...
10191056 Diagnostic evaluation of antibody responses to commonly recognized prostate cancer-associated antigens  
The present invention relates to a plurality of antigens that together form a panel of immunoreactive molecules suitable for identifying candidates for prostate cancer examination. Methods for...
10190173 Recurrent gene fusions in prostate cancer  
Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and...
10190170 Maker for diagnosing HER2 inhibitor resistant cancer, diagnostic kit comprising same, and method for diagnosing HER2 inhibitor resistant cancer  
The present invention relates to a composition for detecting a marker for diagnosing an HER2 inhibitor-resistant cancer, a diagnostic kit including same, and a method for detecting the marker....
10190160 Methods for predicting anti-cancer response  
The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.
10189908 Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants  
Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different...
10189903 Bispecific chimeric antigen receptors and methods of use thereof to treat cancer  
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane...
10189886 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10189875 Anti-cancer peptide and use thereof  
Provided are a peptide consisting of the amino acid sequence of SEQ ID NO:1 or a pharmaceutically acceptable salt thereof, and the use thereof. Cancer can be effectively prevented or treated by...
10189834 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer  
The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Q, R1, R2, R3, R4 and R5 have any of the meanings defined herein. The...
10189782 Derivatives of indole for the treatment of cancer, viral infections and lung diseases  
The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral...
10188877 Fiducial marker/cancer imaging and treatment apparatus and method of use thereof  
The invention comprises a fiducial marker—fiducial detector based treatment room position determination/positioning system apparatus and method of use thereof. A set of fiducial markers and...
10188747 Methods and compositions for the treatment of cancer  
The technology described herein is directed to agonists of, e.g. Esr2, Dlx5, and/or Egr3, for the inhibition of cancer cells (e.g. squamous carcinoma cancer cells) and the treatment of cancer.
10188743 Cytisine-linked isoflavonoid antineoplastic agents for the treatment of cancer  
Cytisine-linked isoflavonoids, or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof, are useful for the treatment of conditions in which cells have a...
10188731 Methods for killing cancer cells and cellular imaging using magneto-electric nano-particles and external magnetic field  
This invention provides methods for achieving high-specificity killing of targeted cells using Magneto-Electric Nano-Particles (MENPs). Embodiments comprise injecting into a patients body...
10188728 Compositions and methods for treatment of cancer  
Provided are compositions, methods and kits for treating cancer comprising targeted liposomes comprising a chemotherapy agent and a sensitizer for the chemotherapy agent, and non-targeted...
10188713 Methods and materials for treating cancer  
This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well...
10188712 Tumor antigens for determining cancer therapy  
The present invention relates to the treatment of cancer, in particular breast cancer, particularly triple-negative breast cancer. More particularly, the invention concerns methods and means for...
10188704 Enhanced melanoma cancer prevention by novel melanotropins  
A gamma-melanocyte stimulating hormone (γ-MSH) derivative having improved stability, selectivity and bioavailabilty. The γ-MSH derivative is selective for the melanocortin-1 receptor (MC1 R) and...