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10058523 Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis  
Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that...
10055842 Entropy-based radiogenomic descriptions on magnetic resonance imaging (MRI) for molecular characterization of breast cancer  
Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One...
10055542 Software interface tool for breast cancer screening  
What is disclosed is a software interface tool for breast cancer screening that is designed for medical professionals to view and analyze suspicious regions for hot spots and hence facilitate a...
10054596 Platelet biomarkers in cancer diagnosis  
The present embodiments relate generally to the field of cancer diagnostics. More specifically the embodiments relate to platelet derived biomarkers used for diagnosis of cancer or cancer...
10054590 Use of nucleolin as a biomarker for lymphangiogenesis in a cancer prognosis and therapy  
The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor...
10053737 Methods and compositions for treating cancer by identifying one or more ERK mutations  
The invention is directed to methods, reagents, and kits for the detection of MAPK/ERK pathway mutations in a patient diagnosed for cancer. In one embodiment, the invention comprises a sensitive...
10053696 MiRNA-489 in treatment of breast cancer  
Breast cancer treatment methods and materials incorporating microRNA-489 are described. The methods and materials have been developed from identification of a double-negative feedback loop between...
10053692 Methods relating to circulating tumor cell clusters and the treatment of cancer  
Described herein are methods and assays relating to the presence and/or level of circulating tumor cells (CTCs). These CTC-Cs represent a highly metastatic subpopulation of CTCs. In some...
10053512 Antibodies against claudin 18.2 useful in cancer diagnosis  
The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether...
10053494 Chemically activated nanocapsid functionalized for cancer targeting  
Modified capsid proteins containing at least a portion of hepatitis E virus (HEV) open reading frame 2 (ORF2) having one or more cysteine residues in a surface variable loop or the C-terminus of...
10052393 Multifunctional nanomaterials for the treatment of cancer  
The invention relates to a multifunctional nanomaterial comprising a nanorod comprising 1) a noble metal, wherein the nanorod exhibits surface plasmon resonance absorption in the near-infrared...
10052371 Compositions and methods for treatment of cancer using bacteria  
Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for...
10052370 HER2/Neu cancer vaccine  
Protein conjugate comprising a protein antigen for generating an immune response against the HER2/neu protein and an immunogenic carrier covalently bonded to said protein antigen, wherein said...
10052314 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer  
Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
10052304 Compositions and methods for cancer therapy  
The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances...
10052085 Diagnostic assembly and method including cold bars for detecting a presence of cancer  
A diagnostic assembly (30, 320) and method for detecting a presence of cancer in a breast of a patient. The diagnostic assembly (20, 320) comprises a frame (22, 322), at least one cold bar (26,...
10049770 Prediction of recurrence of non-small cell lung cancer  
Methods, apparatus, and other embodiments associated with predicting non-small cell lung cancer (NSCLC) patient response to adjuvant chemotherapy therapy using radiomic features extracted from...
10048266 Diagnostic biomarkers and therapeutic targets for pancreatic cancer  
We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected...
10048264 Lung cancer biomarker  
The present invention relates to a lung cancer biomarker for diagnosing early stage lung cancers or predicting prognosis of lung cancers, which comprises a GM2AP protein. The present invention...
10047403 Diagnostic methods for determining prognosis of non-small cell lung cancer  
The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after...
10047402 RASAL1 is a major tumor suppressor gene in thyroid cancer  
The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for treating thyroid cancer. In certain embodiments, the...
10047401 Expression protein-coding and noncoding genes as prognostic classifiers in early stage lung cancer  
The invention provides novel biomarkers (four genes BRCA1, HIF1A, DLC1, and XPO1 alone or in combination of miR-21) for early stage lung cancer.
10047399 ABCA1 downregulation in prostate cancer  
A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of...
10047398 Method for the diagnosis, prognosis and treatment of breast cancer metastasis  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in breast cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
10047397 Breast cancer associated circulating nucleic acid biomarkers  
The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
10047164 Methods and compositions for the treatment of pancreatic cancer  
A composition comprising a TLR2 antagonistic antibody or antigen binding fragment thereof for use in the treatment or prophylaxis of pancreatic cancer is provided. The antibody or antigen binding...
10047151 Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor  
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
10047131 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10047116 Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in fields of medicine including cancer treatment and food related compounds  
The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not...
10047115 Cyclic dinucleotides useful for the treatment of inter alia cancer  
A compound of formula (I) or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The...
10046172 Controller and flexible coils for administering therapy, such as for cancer therapy  
Disclosed herein are systems and methods for providing a portable magnetic field therapy system for treatment of diseases and adverse health conditions, such as cancer.
10046067 Decorin gene delivery system and cancer treatment  
The present invention relates to a novel gene delivery system and recombinant adenovirus comprising the decorin-encoding sequence to enhance transduction efficiency of transgenes, a pharmaceutical...
10046002 Method for treating cancer using chemokine antagonists  
What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically...
10045962 Uses of duloxetine HCL medicament in preparing pharmaceutical treatment of cancer  
Provided in the present invention are uses of duloxetine hydrochloride in preparing a pharmaceutical composition for treatment of cancer.
10045731 Device and apparatus to facilitate cervix cancer screening  
An apparatus for detecting cervical cancer comprising, a mechanical structure configured to expose cervical region comprising, a first duck-billed blade forming a hollow cylinder at one end and a...
10045698 Apparatus and method for detecting a presence of cancer  
A diagnostic apparatus (20) for detecting a presence of breast cancer in a patient disposed in a testing position. The diagnostic apparatus (20) includes a housing (44) and a camera assembly (58)...
10042983 Apparatus for cancer diagnosis  
The present invention provides an apparatus for screening cancer, which reads low-mass ion mass spectrum for diagnosing cancer based on biostatistical analysis with respect to low-mass ions...
10042977 Method utilizing repeat PSA screening for diagnosis of virulent prostate cancer  
A method for detecting aggressive prostate cancer is described, for instance for use in determination of the need for biopsy based. Disclosed methods recognize the difference in PSA rate of change...
10041948 Materials and methods for determining cancer risk  
This document relates to materials and methods involved in assessing inflammatory bowel disease patients at risk for developing cancer. For example, materials and methods for monitoring colorectal...
10041938 Measuring a level of a 5-hydroxymethylcytosine in a sample from a subject having a cancer or suspected of having cancer  
Provided herein are methods and kits for measuring a level of a 5-hydroxymethylcytosine in a nucleotide sequence from a subject, wherein the subject is a subject having a cancer or suspected of...
10041933 Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy  
The present invention relates to modulators of the interaction of astrin and raptor, and their uses in the treatment of mTOR related diseases, such as cancer.
10041129 Immune gene signatures in cancer  
This invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects with cancer, such as colorectal cancer, based on tumor expression levels of...
10041126 Monocyte biomarkers for cancer detection  
The disclosure relates to the field of biomarkers to diagnose a disease, more particularly to the field of biomarkers to diagnose cancer, and most particularly to colorectal cancer. Specifically,...
10041124 Methylation biomarkers for ovarian cancer  
Different combinations of methylation status based biomarkers can be used to test for ovarian cancer with high sensitivity and high specificity.
10041123 Recurrent gene fusions in prostate cancer  
Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer...
10040853 Methods and compositions involving NKG2D inhibitors and cancer  
Embodiments methods and compositions involving inhibitors of the immunoreceptor Natural Killer Group 2, Member D, (NKG2D) for inhibiting tumor progression and treating cancer.
10040846 Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer  
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane...
10040789 1,3,4-thiadiazole compounds and their use in treating cancer  
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6...
10040788 1,3,4-thiadiazole compounds and their use in treating cancer  
The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R1 and R2 have any of the meanings defined herein. The specification also relates...
10039846 Compositions targeting bradykinin receptor B1 for medical imaging of cancer and other disorders  
Bradykinin B1 receptor (B1R) targeting peptides and compounds are radiolabelled with radioisotopes that are suitable for imaging and/or radiotherapy. The radiolabelled peptides and compounds have...