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10646465 Small molecules against cancer  
Compounds capable of, or usable in, killing cancer cells, and/or modulating a biological activity of a chemokine, and/or inhibiting a kinase, and/or treating diseases and disorders associated with...
10646464 Methods for treating cancer  
Methods for treating advanced thymoma and thymic carcinoma in a subject comprising administering and kits comprising at least one paclitaxel compound and at least one compound of formula (I)...
10646460 Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound  
The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical...
10641774 Method for diagnosing cancer by detecting C-terminal segment of moesin in blood  
A method for assessing cancer comprising obtaining a biological sample of the subject, detecting a level of a C-terminal segment of moesin in the biological sample, wherein the level of the...
10640831 Biomarkers for head and neck cancer and methods of their use  
Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell...
10640830 Drug selection for non-small cell lung cancer therapy  
The present invention provides methods for selecting a suitable anticancer drug for the treatment of patient with non-small cell lung cancer (NSCLC). The present invention also provides methods...
10640567 Anti-CD40 antibodies and methods of treating cancer having CD40+ tumor cells  
The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell...
10640535 Identification of MHC class I phospho-peptide antigens from breast cancer utilizing SHLA technology and complementary enrichment strategies  
The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and...
10640524 Prototype systems of theranostic biomarkers for in vivo molecular management of cancer  
The present invention relates to a theranostic system comprising a beacon and a compound selected from the group consisting of a quinazoline-based tyrosine kinase inhibitor and a natural product....
10640493 Phthalazine derivatives as inhibitors of PARP1, PARP2, and/or tubulin useful for the treatment of cancer  
This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these...
10639363 Cancer immunotherapy using virus particles  
A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
10639348 Peptides with anti-cancer activity  
The peptides of the invention are of formula (I) or (IV). The peptides of the invention are useful in the treatment of cancer.
10639338 Traditional Chinese medicine composition for treating prostate cancer, preparation method and application thereof  
The present invention relates to a traditional Chinese medicine composition for treating prostate cancer and its preparation method and application. The composition is prepared from Ganoderma...
10639337 Method for treating cancer with a Coxsackievirus B3 (CVB3) variant  
The present invention relates to a method for treating cancer in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a Coxsackie B3 group...
10639332 Peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10639331 Peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10639329 Method to treat cancer with engineered T-cells  
Novel adoptive immunotherapy compositions comprising co-cultured lentiviral vector-transduced autologous antigen presentation cells and T cells are provided herein as well as are methods of use of...
10639313 Compound for inhibition of delta-5-desaturase (D5D) and treatment of cancer and inflammation  
Tricyclic compounds, including tricyclic iminodibenzylic and tricyclic iminostilbene compounds, are identified as therapeutic agents for inhibition of delta-5-desaturase (D5D) and for treating or...
10636513 Using cancer or pre-cancer subject sequencing data and a database of therapy biomarker distributions to determine normalized biomarker scores and generate a graphical user interface  
Techniques for generating therapy biomarker scores and visualizing same. The techniques include determining, using a patient's sequence data and distributions of biomarker values across one or...
10633710 Methods for characterizing cancer  
A method of identifying gene expression associated with recurrence free survival in a subject with cancer, comprising: a) assaying a sample from a subject diagnosed with cancer for the presence of...
10633708 Biliary tract cancer detection kit or device, and detection method  
The present invention provides a kit or device for the detection of biliary tract cancer, and a method for detecting biliary tract cancer. The present invention relates to a kit or device for the...
10633707 Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway  
Described are mismatch repair (MMR-)deficient tumors. Markers are presented herein having a high sensitivity to detect whether a tumor is mismatch repair deficient or not. The markers are...
10633663 Therapeutic strategies for ovarian cancer: AMHR2-RNA aptamer  
Various aspects of the invention relate to aptamers that specifically bind Müllerian inhibitory substance II receptor (MISIIR).
10633452 Anti-cancer antibodies with reduced complement fixation  
The invention provides modified antibodies directed against GD2 that have diminished complement fixation relative to antibody-dependent, cell-mediated cytotoxicity, which is maintained. The...
10633448 IGF-1R antibody-drug-conjugate and its use for the treatment of cancer  
The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of...
10633440 Multi-chain polypeptide-containing tri-specific binding molecules that specifically bind to multiple cancer antigens  
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated...
10633374 Small molecule based antibody-recruiting compounds for cancer treatment  
The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including...
10633367 Fluorine- and/or deuterium-containing compounds for treating non-small cell lung cancer and related diseases  
Novel fluoride and/or deuterium-containing chemical, compounds useful for treating cancer or a related disease or disorder thereof, and pharmaceutical compositions and methods of preparation and...
10632179 Methods and compositions for treating cancer  
A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of an agent that specifically binds to or complexes with a proteolytically cleaved...
10632160 Probiotic composition for preventing, improving or alleviating pancreatic cancer and application thereof  
The present invention relates to a probiotic composition for preventing, improving or alleviating pancreatic cancer and a method for preventing, improving or alleviating the pancreatic cancer and...
10632151 Cancer immunotherapy  
Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.
10632140 Methods relating to lung cancer  
The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by...
10632110 Pharmaceutical composition for preventing or treating cancer and method using thereof  
Provided are a pharmaceutical composition for preventing or treating cancer and a method of preventing or treating cancer using the same. Cancer may be effectively prevented or treated using the...
10632106 Methods of cancer treatment with 2-(1′H-Indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester  
Provided herein are methods of cancer treatment by administering an effective amount of an endogenous ligand for the aryl hydrocarbon (Ah) receptor (AhR) named ITE or one of its structural analogs...
10632081 Intralymphatic delivery of hyaluronan nanoparticle for cancer metastasis  
Disclosed is an intralymphatic delivery method for treating lymphatic cancer using hyaluronan nanoparticles. These nanoparticles include a hyaluronic acid derivative and a platinum compound. The...
10627413 Method of cancer diagnosis, progression and response to therapy using a primary xenograft mouse model for cancer serum biomarker discovery  
A method of determining disease diagnosis, progression and response to therapy through the use of xenograft animal models for determining cancer biomarkers is presented. In use, a tumor from a...
10627402 Peptides for targeting gastric cancer, and medical use tehreof  
Provided is a peptide for targeting gastric cancer, a composition for diagnosing radioresponsiveness-dependent gastric cancer using the peptide, and a drug delivery use of the peptide, wherein a...
10626464 Methods of detecting prostate cancer  
The invention described herein provides biological markers for the diagnosis, prognosis, and monitoring of prostate cancer.
10626462 Methods and nucleic acids for determining the prognosis of a cancer subject  
The invention provides methods, nucleic acids and kits for determining the prognosis of a subject having cancer. The invention discloses genomic sequences the methylation patterns of which have...
10626397 Therapeutic compositions for breast cancer containing protein kinase D1 inhibitor  
A method of inhibiting the growth of cancer stem cells, including administering an effective amount of a protein kinase D1 expression or activity inhibitor as an active ingredient to a subject...
10626377 Use of an oncolytic virus for the treatment of cancer  
The present invention provides a method of treating cancer, which comprises administering a therapeutically effective amount of an oncolytic virus, an inhibitor of the indoleamine 2,3-dioxygenase...
10626184 Monoclonal antibodies, compositions and methods for detecting mucin-like protein (MLP) as a biomarker for ovarian and pancreatic cancer  
In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such...
10626183 IFN-γ-inducible regulatory T cell convertible anti-cancer (IRTCA) antibody and uses thereof  
Provided are IFN-γ-Inducible Regulatory T Cell Convertible Anti-Cancer (IRTCA) antibodies and antigen-binding fragment thereof that bind to an activation-inducible TNFR (AITR) polypeptide. Various...
10626174 Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors  
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use...
10626162 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10625097 Semi-automated cancer therapy treatment apparatus and method of use thereof  
The invention comprises a method for treating a tumor of a patient with positively charged particles in a treatment room, comprising the steps of: (1) controlling a cancer therapy treatment system...
10624968 Compounds for treating cancer  
The present invention provides compounds, compositions thereof, and methods of using the same.
10624951 SRPX for treatment of cancer  
Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
10624881 Methods for inducing apoptosis in cancer cells  
Provided are methods for inducing apoptosis of cells using quinolinol compounds. Combinations of quinolinol compounds can be used in the methods. Combinations of one or more quinolinol compound...
10620228 Lung cancer detection kit or device, and detection method  
It is intended to provide a kit or a device for the detection of lung cancer and a method for detecting lung cancer. The present invention provides a kit or a device for the detection of lung...