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10030269 Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism  
The present invention relates to the discovery that the modulation of particular microRNAs can be employed to inhibit a mesenchymal transition that, in certain instances, correlates with...
10030227 Canine autologous immunotherapy using dendritic cell induced cancer killing immunocytes  
Described are compositions of matter, protocols, and treatment means for induction of immune mediated killing in dogs suffering from cancer. The invention provides means of extracting peripheral...
10030074 Methods of inducing or enhancing an immune response in a subject having cancer by administering GITR antibodies  
The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by...
10030044 Nucleotides for the treatment of liver cancer  
Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments,...
10030039 Anti-cancer agent and cancer cell killing method  
[Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a complex produced by making a metal-salen...
10030036 Method and dyes for detecting and destroying cancer cells  
This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer...
10029991 Modulators of development of adipocyte and cancer cells  
One aspect of the disclosure relates to derivatives of aryl and heterocyclic ureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea, curcumin, and...
10029956 Therapies for cancer using isotopically substituted lysine  
Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.
10029124 Multiple beamline position isocenterless positively charged particle cancer therapy apparatus and method of use thereof  
The invention comprises a method and apparatus for treating a tumor with protons using multiple beamline positions not having an isocenter, including the steps of: (1) delivering the protons from...
10029003 Methods and materials for treating cancer  
This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well...
10028997 Systems and methods for attracting and trapping brain cancer cells  
Described herein are systems and methods for attracting and trapping cancer cells at a specific site where focal radiation and/or surgical resection and/or chemotherapeutics can eliminate them.
10028989 Composition comprising Retinol, a precursor or a reaction product of it and a plant extract from at least one Chamomilla plant for the treatment of cancer  
The invention relates to a (i) Vitamin A, a reaction product, a metabolite or a precursor of it and (ii) a plant extract of chamomile or an active component thereof, preferably for use in the...
10028958 Methods of treating cancer with a combination of selected MEK1/2 and AXL inhibitors  
Methods, compounds and kits relating to treating cancer, reducing kinase inhibitor or resistance, and reducing or preventing diminished ectodomain shedding are described.
10028911 Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent  
Disclosed is are formulations comprising a multivesicular liposome and MTX, the administration of which results in a Cmax of MTX between 5% and 50% of the Cmax of an immediate release dosage form...
10024860 Cancer-related extracellular matrix signatures and related methods and products  
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with...
10024859 Markers for detection of gastric cancer  
Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric...
10024857 Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis  
Biomarkers of pancreatic cancer are described, as well as methods using these compounds for detecting pancreatic cancer. The methods can be used to diagnose a patient's health state, or change in...
10023916 Markers of tumor cell response to anti-cancer therapy  
Compositions and methods for determining circulating biomolecules before, during, and/or after treatment of a patient with an anti-cancer or anti-tumor drug (or putative drug) are described....
10023915 Method for screening for a cancer treatment agent using the interaction between PAUF and a binding partner thereof  
The present invention relates to a method for screening for a cancer treatment agent by contacting a test material with pancreatic adenocarcinoma upregulated factor (PAUF) and GLRX3, SNAPIN, or...
10023871 Double-stranded polyC:poly(G/I) RNA for immunostimulation and cancer treatment  
The present invention relates to polyC:poly(G/I) dsRNAs for triggering innate immunity, in particular through toll-like receptor 3 (TLR-3) and, optionally, RIG-I or RIG-I-like receptors (RLRs), as...
10023858 System and method for selective ablation of cancer cells with cold atmospheric plasma  
A method for elevating a TRAIL-R1 expression in cancer cells to induce apoptosis. The method comprises the steps of receiving electrical energy having a specific voltage, frequency and power from...
10023841 Methods and compositions for treating breast cancer with dendritic cell vaccines  
Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy....
10023652 Method of targeting glycoproteins to treat cancer  
The present disclosure relates to a method of inhibiting tumor growth. More specifically, the present disclosure relates to the use of monoclonal antibodies for targeting truncated O-glycans on...
10023649 Method of treating cancer with a combination of an anti-CCR4 antibody and a 4-1BB agonist  
The present disclosure describes combination therapies comprising an antibody which specifically binds to human CCR4 and a selective 4-1BB agonist, and the use of the combination therapies for the...
10023637 Combination immunotherapy for the treatment of cancer  
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the treatment of tumors.
10023588 Compositions and methods for treating cancer  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
10022444 Combination therapy involving antibodies against Claudin 18.2 for treatment of cancer  
The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric...
10022441 Method for improving the efficacy of a survivin vaccine in the treatment of cancer  
The present invention provides methods for improving the efficacy of a vaccine in the treatment of cancer. The methods of the invention comprise the administration of at least two doses of an...
10022431 Methods and materials for treating cancer  
This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.
10022405 IL-12 immunotherapy for cancer  
Compositions and methods far delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery...
10022402 Allogenic mesendritic vector for ovarian cancer  
A method of preparing an allogenic dendritic stem cell vaccine for treating ovarian cancers is disclosed. The method comprises, (a) collecting blood sample from an allogenic donor in a sterile...
10022390 Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer  
Phosphoramidate derivates of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a...
10022364 Methods of treating cancer patients with farnesyltransferase inhibitors  
The present invention relates to the field of molecular biology and cancer biology. Specifically, the present invention relates to methods of treating a subject with a farnesyltransferase...
10022356 Compounds for treatment of cancer  
The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g. trametinib, RO5068760), in combination...
10022325 Compositions and methods for the treatment of cancer  
The present invention provides compositions and methods for the treatment of cancer are provided.
10018639 Kits for detecting breast or ovarian cancer in a body fluid sample and use thereof  
The present invention relates to a method for the accurate, rapid and sensitive detection of breast or ovarian cancers from body fluid samples of a mammalian subject and related assay, kits and...
10018630 Cancer stem cell isolation  
An objective of the present invention is to provide: a cancer stem cell isolated using a cell marker; a substantively homogeneous cancer stem cell population including said cancer stem cell; and a...
10017579 Anti-cancer antibodies with reduced complement fixation  
The invention provides modified antibodies directed against GD2 that have diminished complement fixation relative to antibody-dependent, cell-mediated cytotoxicity, which is maintained. The...
10017578 Methods of treating cancer in a patient by administering anti-folate-receptor-1 (FOLR1) antibodies  
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are...
10017576 Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies  
The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the invention are a pharmaceutical...
10017567 Treatment of cancer with anti-LAP monoclonal antibodies  
Described herein are compositions and methods relating to LAP-binding agents, including, for example, anti-LAP antibodies, and to their use in methods of treatment of cancer. LAP-binding agents...
10017564 Monoclonal antibodies against claudin-18 for treatment of cancer  
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric...
10017475 Anti-vasculature and anti-tubulin combretastatin analogs for treatment of cancer  
Combretastatins analog compounds and their pharmaceutically acceptable salts are presented, as well as pharmaceutical compositions comprising the combretastatin analog compounds and uses of the...
10016620 Tissue sampling and cancer treatment apparatus  
A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured...
10016619 Systems and methods for treating cancer using brachytherapy  
Systems and methods are provided for treating cervical and/or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion...
10016519 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer  
The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of...
10016484 Methods of treating lung cancer  
Methods of treating cancers comprising FGFR1 gene amplification are provided. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular...
10016480 Peptide-based methods for treating pancreatic cancer  
Methods for treating a subject for pancreatic cancer via administration of small anti-inflammatory peptides are disclosed. The peptides may be administered in conjunction with another therapeutic...
10016470 Oncolytic adenoviruses for cancer treatment  
The invention relates to an oncolytic adenovirus for the treatment of cancer, containing a human DNA sequence isolating a promoter conferring selective expression on an adenoviral gene. Said...
10016468 Method and compositions for treating cancer using probiotics  
The subject invention pertains to probiotic compositions and methods of treating hepatocellular carcinoma (HCC) using the probiotic compositions. The probiotic compositions can inhibit growth of...