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8513294 Substituted imidazole derivatives and methods of use thereof for treating cancer  
Disclosed are compounds of the general formula (I): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods...
8513292 Compositions and methods for the treatment of cancer  
The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising...
8513276 Imidazo[1,2-a]pyridine compounds for use in treating cancer  
The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of...
8513266 Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K alpha  
The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination...
8513222 Methods of treating fibrosis, cancer and vascular injuries  
This invention relates to use of inhibitors of the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4) in treating, preventing, or reducing f...
8513212 Bruton's tyrosine kinase as anti-cancer drug target  
Receptor protein tyrosine kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions....
8513210 Prostate cancer vaccine  
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer. Also...
8512951 Methods for diagnosing stomach cancer using MicroRNAs  
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
8512944 PRMT1 for target genes of cancer therapy and diagnosis  
Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma,...
8512716 Diagnostic, predictive and prognostic testing for cancer  
The present invention relates to a method for determining a prognosis of progression of a cancer in a subject, a method for determining a treatment protocol for a subject having cancer or a method...
8512713 Myxoma virus mutants for cancer treatment  
Myxoma viruses that are deficient in the activity of a Myxoma virus protein selected from the group consisting of M11L, M063, M 136, M-T4 and M-T7 are useful for treating cancer.
8512702 Prostate cancer diagnosis and treatment  
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof. The present invention also...
8512701 Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration  
Methods for prevention or inhibition of the growth or metastasis of cancer cells in a subject are disclosed. One method comprises the step of administering to the subject a therapeutically...
8509570 Method and apparatus for computer-aided diagnosis of cancer and product  
Method and apparatus performing dynamic contrast-enhanced-magnetic resonance imaging on tissue to obtain a plurality of datasets of images. Principal component analysis is performed on each dataset...
8507555 Non-toxic anti-cancer drug combining ascorbate, magnesium and a naphthoquinone  
Compositions comprising combinations of magnesium ascorbate (magnesium Vitamin C of “MgVC2”) and Vitamin K3 or (VK3) or a quinone and semiquinone analogue of VK3, are used in methods for kil...
8507531 Water-soluble zinc ionophores, zinc chelators, and/or zinc complexes and use for treating cancer  
Disclosed herein are novel zinc ionophores, zinc chelators and/or zinc complexes with enhanced aqueous solubility. Methods of treating cancer using at least one zinc ionophore and/or zinc chelator...
8507523 Therapeutic tetrahydroisoquinoline-based compositions for cancer therapy  
Disclosed are therapeutic tetrahydroisoquinoline compositions for the treatment of cancer, these compositions having selectivity for cancer cells while demonstrating few, if any, deleterious side...
8507495 Sensitizer, kit and use for cancer therapy  
A cancer therapy sensitizer is disclosed. The cancer therapy sensitizer includes rapamycin and substituted quinoline. The present invention discloses a cancer therapy sensitization kit containing...
8507459 Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer  
The present invention relates to the novel use of an adenosine aspartate product for the formulation of a drug intended to prevent the development of preneoplastic lesions and to reverse some types...
8507445 Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer  
The present invention concerns compositions comprising and methods of identification and use of targeting peptides selective for cancer tissue, particularly prostate or ovarian cancer tissue. The...
8507245 Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents  
Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral...
8507202 Methods for diagnosing pancreatic cancer using MicroRNAs  
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
8507195 MiRNAs dysregulated in triple-negative breast cancer  
The invention provides methods of diagnosing and treating cancer in a subject. The inventors have identified a series of dysregulated miRNAs that are indicative of triple-negative breast cancer. In...
8506954 Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy  
In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments,...
8502015 Method of inducing cancer  
A method induces cancer, such as ovarian cancer, in primates for testing of therapeutic treatments and preclinical research and development. A nanoparticle delivers plasmid DNA encoding oncogenes...
8501953 PKM2 modulators for use in the treatment of cancer  
Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the...
8501912 Filipil compositions and methods for treating cancer  
A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A method of inhibiting angiogenesis in...
8501906 Compounds and methods for treating cancer  
The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also...
8501792 Treating cancer with desthiazolyl ritonavir  
Treatment of cancer includes administering a compound of formula I, for example des-ritonavir, to a subject. In particular, treatment of breast cancer is described.
8501752 Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2,3-d]pyrimidines  
The present invention provides methods for treating cancer and other pathological proliferating conditions by inhibiting mitosis using at least one pyrrolo[2,3-d]pyrimidine having the general...
8501483 Method of assessing cancer status in a breast cancer patient  
Described are methods for assessing recurrence status in a breast cancer patient that include assaying a biological sample from the patient for a level of a biomarker selected from such as S100β ...
8501472 Compositions and methods for treating and diagnosing pancreatic cancer  
The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides...
8501417 Immunological compositions as cancer biomarkers and/or therapeutics  
The present invention concerns antibodies that react immunologically with anti-tumor antigen antibodies and compositions and methods related thereto. In particular, the antibodies that react...
8501243 Targeting cancer therapy combination  
Methods for treating neoplasm, tumors and cancers, using one or more tumor treating drug carriers, haptens and anticancer drugs, alone or in combination with other antineoplastic agents or...
8501241 Treating cancer with a whole, leech saliva extract  
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing...
8501233 Compositions and methods for treating cancer  
The present invention relates to compositions and methods for treating cancer and, in particular, to composition and methods comprising nanostructures. In one embodiment, the present invention...
8501167 Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer  
Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in...
8498822 Genomic classification of colorectal cancer based on patterns of gene copy number alterations  
The invention is directed to methods and kits that allow for classification of colorectal cancer cells according to genomic profiles, and methods of diagnosing, predicting clinical outcomes, and...
8497398 Polyamine transporter selective compounds as anti-cancer agents  
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel...
8497352 Use of Wnt5-α peptide derivates for the treatment of melanoma and gastric cancer  
The present invention relates to a novel unbranched carbamate derivative, in particular N-butyloxycarbonyl derivative of certain Wnt5-α peptides and to their use in the treatment of melanoma or ...
8497351 Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer  
A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
8497349 Use of multivalent synthetic ligands of surface nucleolin for treating cancer or inflammation  
A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising...
8497348 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
8497296 N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells  
The invention is directed to a compound of Formula (I), wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R1 is selected from the group...
8497257 Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis  
The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a)...
8497084 15-PGDH in colon cancer  
The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the...
8492413 Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer  
New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium...
8492361 Methods for treating non-small cell lung cancer using 5-azacytidine  
The present disclosure provides methods for treating subjects having non-small cell lung cancer, wherein the methods comprise administering to the subject a cytidine analog, such as 5-azacytidine....
8492133 MIR-21 promoter driven targeted cancer therapy  
The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which...
8492104 Methods and kits to detect and monitor ovarian cancer and preeclampsia  
The present invention provides methods and kits related to a prognostic, and, in certain embodiments, diagnostic indicator for ovarian cancer which comprises measuring the level of MUC16 bound to...