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8558000 4-pyridinone compounds and their use for cancer  
Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or...
8557983 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
8557964 Anti CXCR4 antibodies and their use for the treatment of cancer  
The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the...
8557787 Diagnostic, prognostic and therapeutic uses of long non-coding RNAs for cancer and regenerative medicine  
Long non-coding RNAs (lncRNAs) and methods of using them diagnostically and therapeutically for treatment of cancer, stem cell therapy, or regenerative medicine are disclosed. In particular, the...
8557779 Cancer vaccine composition  
A cancer vaccine composition for human leukocyte antigen (HLA)-A*0206-positive persons, comprising a protein product of the tumor suppressor gene WT1 or a partial peptide thereof.
8557777 Methods for treating cancer using prostate specific antigen and tumor endothelial marker peptides  
The present invention is directed to prostate specific antigen (PSA) and tumor endothelial marker 8 (TEM8) peptide compositions and methods for treating cancer with the compositions.
8557528 Detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition in body fluids of cancer patients  
The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods. According to the present invention said method...
8557525 Composite metastasis score with weighted coefficients for predicting breast cancer metastasis, and uses thereof  
The present invention relates to a composite metastasis score (“cMS”) based on expression of a 14-gene molecular signature (referred to as a metastasis score, or “MS”) in combination with progest...
8557520 Methods for diagnosing prostate cancer using MicroRNAs  
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
8557516 AKT tyrosine 176 phosphorylation cancer biomarker  
AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. The present study uncovered that growth...
8557515 Compositions and methods for cancer diagnosis and therapy  
The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate...
8557257 Mycobacterial immunotherapy for cancer treatment  
Methods of Mycobacterial immunotherapy for the treatment of cancer are described. In certain cases, these methods concern administration of attenuated Mycobacteria by intradermal injection into non...
8557245 Methods for treating bone cancer by administering a nerve growth factor antagonist antibody  
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth...
8554518 Discrete principal component analysis (DPCA) for pattern recognition and diagnostics of tissue pathologies such as cancer  
A method for recognizing figures in an image frame provided by an optical device is disclosed. The method includes selecting a set of calibration images having characteristic figures; selecting a...
8552048 Phosphoramidate alkylator prodrugs for the treatment of cancer  
Compositions containing, and, methods administering, TH302, are useful in treatment of cancer and other hyper-proliferative diseases.
8552016 Anti-cancer cyclopenta(g)quinazoline compounds  
Cyclopenta[g]quinazolines of the formula (I): wherein: A is a group OR or NR0R1 wherein R0 and R1 are each independently hydrogen C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4...
8551971 Composition for treatment of pancreatic cancer  
Disclosed is a composition for treating pancreatic cancer. The composition comprises a pharmaceutically effective amount of an antisense nucleic acid or siRNA that inhibits expression of at least...
8551943 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8551735 Method of diagnosing gastric cancer by using human neutrophil peptide 1-3  
Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present...
8551539 Herbal medicinal composition and extract thereof for inhibiting growth of cancer cells  
The present invention relates to herbal medicinal compositions and extracts thereof for inhibiting growth of cancer cells. One of the examples described in the present invention comprises...
8551488 Binding molecules for treatment and detection of cancer  
Provided are new tumor-associated antigens, binding molecules that specifically bind to the antigens, nucleic acid molecules encoding the binding molecules, compositions comprising the binding...
8551486 Monoclonal antibodies to human thymidine kinase to treat cancer  
A method of treatment of cancer, viral infections, and the like administers anti-TK1 antibody, constituted as the complete antibody or a fragment thereof. The antibody binds to the surface of cells...
8551481 Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody  
Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation...
8551425 Method for cancer detection, diagnosis and prognosis  
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC),...
8546551 Method to detect prostate cancer in a sample  
The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate...
8546433 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer  
This invention is directed to methods of preventing, treating or managing cancer, preferably metastatic cancer, in a patient. The methods comprise administering an effective amount of an Axl...
8546426 N-aminotetrahydroisoquinolines as anti-cancer agents  
The compounds herein disclosed are tetrahydroisoquinoline analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of...
8546399 Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
8546390 6-(pyrrolopyridinyl) pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and AIDS  
Compounds of the formula (I), in which R1, R2, R3 and R4 have the meanings indicated in claim (1), are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumors.
8546320 Hsp9O-targeted anti-cancer chimeric peptide  
Disclosed is a substance which is not accumulated stably in cells, does not cause the dysfunction of normal cells, and so on, and therefore can be used as an anti-cancer agent or in a DDS without...
8546078 Materials and method for assaying for methylation of CpG islands associated with genes in the evaluation of cancer  
Provided are methods, reagents, and kits for evaluating cancer, such as prostate cancer, in a subject. Disclosed methods of evaluating cancer include methods of diagnosing cancer, methods of...
8545840 Methods for treating cancer using an immunotoxin  
The present invention relates to methods for preventing or treating head and neck squamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the...
8545838 Compositions and methods for cancer immunotherapy  
Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that...
8545835 Human prostate cell lines in cancer treatment  
The invention provides methods and compositions for the treatment of primary, metastatic, and residual cancer in mammals, and more particularly, the use of materials such as whole cells and...
8545812 Transport agents for crossing the blood-brain barrier and into brain cancer cells and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished...
8541544 Molecular marker for cancer stem cell  
A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of...
8541467 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ  
The present invention refers to the use of the compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of h...
8541433 Combination comprising macitentan and paclitaxel for treating multi-drug resistant ovarian cancer  
The invention relates to the combination of an endothelin receptor antagonist of formula (I) with paclitaxel, and in particular to this combination for therapeutic use, simultaneously, separately...
8541390 Treatment of cancer by inhibition of IGFBPs and clusterin  
Agents that reduce the amount of IGFBP-2 and/or IGFBP-5 and that are known to be useful in the treatment of cancer result in increased expression of the protein clusterin. Since clusterin can...
8541382 Cardiac glycoside analogs in combination with emodin for cancer therapy  
A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a...
8541186 Cancer detection methods and techniques  
A method is provided for detecting and/or measuring the occurrence of an enzyme in the form of CYP1B1 in a patient for the detection of cancer in said patient. The method includes the steps of...
8541169 Prostate cancer-specific alternations in ERG gene expression and detection and treatment methods based on those alterations  
The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The...
8540998 Methods for treating cancer using ephrin type-A receptor 10 antibodies conjugated to cytotoxic agents  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,...
8540989 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
8540968 Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof  
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting...
8540964 Polyvalent conjugate vaccine for cancer  
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated...
8535929 Parvovirus having a CPG-enriched genome useful for cancer therapy  
A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of...
8535678 Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders  
Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the...
8535677 Antibody drug conjugate treatment of colorectal cancer  
The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer...
8535674 Treating breast cancer and inhibiting cancer-associated bone loss with anti-IL-20 antibody  
Use of an anti-IL-20 antibody, either alone or in combination with an anti-RANKL antibody, for treating breast cancer and inhibiting cancer-associated bone loss.