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9486471 Combination therapy for the treatment of cancer  
Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic...
9486467 Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin  
The present invention includes methods for treating or preventing a cancer in a mammal comprising administering to the mammal a therapeutically effective amount of a macrolide antibiotic such as...
9486466 Veliparib in combination with carboplatin for the treatment of triple negative breast cancer  
The invention relates to a method for the treatment of triple negative breast cancer in a subject, comprising administering to the subject an effective amount of...
9486449 Cancer therapy  
The subject invention provides for cancer therapy.
9486444 Anti-cancer compound  
Anti-cancer compounds include N-arylmethylidene piperidones having structural formula I: where R is a hydrogen, halogen, methyl, methoxy, or nitro group, or a pharmaceutically acceptable salt thereof.
9486434 Method for delivery and use of isothiocyanates for prophylaxis and/or therapy of bladder cancer  
Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a...
9481885 Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis  
The present invention provides materials and methods related to the discovery that tumor secreted miR-21 and miR-29a can function by binding as ligands to receptors of the Tolllike receptor...
9481728 Compositions and methods for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
9481693 Mixed ligand gold(III) complexes as anti-cancer agents  
Gold(III) complexes with mixed ligands as anticancer agents. The gold(III) cations are coordinated to bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and a...
9480754 Phospholipid ether analogs as cancer-targeting drug vehicles  
The present invention is directed to therapeutic compounds capable of targeting cancer cells and cancer stem cells. The present invention is further directed to compositions comprising these...
9480745 Targeted treatment of anerobic cancer  
The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in...
9480725 Fermented wheat germ proteins (FWGP) for the treatment of cancer  
The present invention provides compositions comprising the component of fermented wheat germ extract (“FWGE”) active in reducing, inhibiting or preventing the proliferation of cancer cells and/or...
9480664 Compositions and methods for treating cancer  
Compositions containing one or more COX inhibitors in combination with one or more antagonists of 20-HETE (20-hydroxyeicosatetraeonic acid), and optionally a pharmaceutically acceptable excipient...
9480653 Protocells and their use for targeted delivery of multicomponent cargos to cancer cells  
Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to...
9476883 Cellular recognition conjugates and methods of use for the histological analysis of cancer tissue using MALDI-MS imaging  
Disclosed are conjugates that can bind to one or more site on cancer cell surface, for example, surface proteins, compound specific receptors and carbohydrates that comprise the surface of...
9476882 Methods and compositions for diagnosing and treating cancer  
The invention provides assays, methods, systems, compositions, and kits for diagnosing and treating cancer.
9476871 System and method for automated determination of the relative effectiveness of anti-cancer drug candidates  
A computer system is provided for determining the relative effectiveness of anti-cancer drugs. The interface has selectable options, including an option to manage drug testing parameters, and...
9476100 Methods for diagnosing bladder cancer  
Methods and kits for identification of bladder cancer in a subject based on alterations in DNA methylation at selected genomic loci are provided.
9476098 Multigene prognostic assay for lung cancer  
The present invention provides methods for providing a prognosis for lung cancer using a panel of eleven molecular markers that includes BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3,...
9475871 Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins  
The present invention provides methods of treating a patient having a cancer comprising administering to the patient a soluble Fibroblast Growth Factor Receptor 1 (FGFR1) fusion protein such as an...
9475867 Monoclonal antibodies for treatment of cancer  
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast...
9474783 HIP/PAP protein and derivatives thereof for use in treating cancer  
This invention concerns a HIP/PAP protein or derivative thereof, for its use in treating or managing cancer and preferentially solid tumors.
9474777 Plant extract and the process for treating hepatic fibrosis and liver cancer  
An extract of Graptopetalum paraguayense prepared by a method that includes: extracting a Graptopetalum paraguayense (GP) starting material with an alcoholic solvent to produce an alcoholic...
9474757 Methods for treating cancer using TOR kinase inhibitor combination therapy  
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of a 5-Substituted Quinazolinone...
9474490 Methods and systems of evaluating a risk of a gastrointestinal cancer  
A method of evaluating gastrointestinal cancer risk. The method comprises generating a set of features comprising a plurality of current blood test results from a blood collected from a target...
9470697 Methods for detecting risk of fatal prostate cancer using serum calcium  
A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an...
9470690 Human cancer-related gene, its encoded products and applications  
The invention discloses a human cancer-related gene, LAPTM4B, its encoded products and their applications thereof. This human cancer-related gene provided by this invention comprises one of the...
9470689 N-cadherin: target for cancer diagnosis and therapy  
The present invention provides methods of diagnosis, providing a prognosis and a therapeutic target for the treatment of cancers that express N-cadherin, including prostrate and bladder cancers.
9470688 Identification of cancer protein biomarkers using proteomic techniques  
The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to...
9469878 Methods of treating cancer comprising targeting NQO1  
Disclosed herein are methods for determining whether an individual with cancer is suitable for a treatment with an NQO1 bioactivatable drug, predicting responsiveness of an individual with cancer...
9469877 Materials and methods for diagnosis, prognosis, monitoring of recurrence, and assessment of therapeutic/prophylactic treatment of pancreatobiliary cancer  
A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of...
9469876 Circulating biomarkers for metastatic prostate cancer  
Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating...
9469852 Methods and compositions using miR-3151 in the diagnosis and treatment of cancer  
Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided.
9469846 Compositions and methods for treating cancer  
A composition for inhibiting cancer cell proliferation includes exogenous constitutively active Chk1 or an agent that promotes phosphorylation of endogenous Chk1 of the cancer cell.
9469841 Prodrug activation in cancer cells using molecular switches  
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a...
9469656 HDAC inhibitors as anti-cancer agents  
Largazole analogs, methods of making the same, and methods of using the same, are described.
9468690 Decorin gene delivery system and cancer treatment  
A novel gene delivery system and recombinant adenovirus includes a decorin-encoding sequence to enhance transduction efficiency of transgenes. A pharmaceutical anti-tumor composition includes the...
9468687 Immuno gene therapy for treatment of cancer and hyperproliferative diseases  
Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative...
9468646 Increased dosage of efavirenz for the treatment of cancer  
The invention is based on the finding that an increased daily dose of Efavirenz should be used for the treatment of cancer compared to the daily dose used in the treatment of AIDS. The invention...
9468632 Methods and compositions for targeting cancer stem cells  
The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic...
9468603 Nanoparticulate compositions for targeted delivery of acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation  
In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol...
9464328 Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease  
Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such...
9464326 Total and phosphorylated IL-1 receptor-associated kinase-1 and IL-1 receptor-associated kinase-4 as a biomarker for cancer progression and chemotherapy resistance  
Toll-like receptors (TLR) are expressed by a variety of cancers, including melanoma and T-ALL. TLR signaling plays an important role in T cell malignancies and melanoma. The effects of stimulating...
9464325 Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer  
The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof....
9464293 RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells  
In some embodiments, aptamers that specifically bind pancreatic cancer cells are provided. Such aptamers may include an RNA molecule that specifically binds a pancreatic cancer cell surface...
9464291 Methods and compositions for the treatment of cancer  
Some embodiments of the present invention relate to agents and compositions for treating cancer. More embodiments include agents and compositions for modulating the activity of the Hedgehog pathway.
9464140 Compositions and methods for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
9464093 Substituted imidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines and oxazolo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines for treating brain cancer  
This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers. For example, such compounds include a compound of Formula I or a...
9463242 Methods for treating prostate cancer  
Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.
9463219 Method for treating brain cancer using a novel tumor suppressor gene and secreted factor  
The present invention is directed to methods of using HSS1 (Hematopoietic Signal peptide-containing Secreted 1), HSM1 (Hematopoietic Signal peptide-containing Membrane domain-containing 1), or a...