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8765467 Multicellular compositions of pluripotent human embryonic stem cells and cancer cells  
Methods are provided for producing novel multicellular compositions comprising cancer cells together with pluripotent human stem cells, which are capable of proliferating and differentiating into...
8765463 Chimeric adenoviruses for use in cancer treatment  
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
8765462 IL-12 immunotherapy for cancer  
Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery...
8765388 VHZ for diagnosis and treatment of cancer  
We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or...
8765383 Methods of predicting cancer risk using gene expression in premalignant tissue  
The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal...
8765368 Cancer risk biomarker  
The present disclosure relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer. Also provided are methods...
8762069 Therapeutic implications of dickkopf affecting cancer stem cell fate  
A method of determining a therapeutic regimen for the treatment of cancer with Dickkopf (Dkk) protein in which a mathematical model of differential equations describing the major signaling...
8759546 Physical nano-complexes for preventing and treating cancer and method for manufacturing the same  
The present invention discloses a physical nano-complex for preventing and treating cancer and a method for manufacturing the same. The composition contains EGCG and nanogold, wherein the ratio of...
8759520 Compounds for treating cancer  
Compounds of general formula (I): wherein R1, R2, R3, R4, R5, R6, X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterized by abnormal cell growth...
8759367 Compounds and methods for the prevention and treatment of cancer  
The present invention relates to compounds for modulating sonic hedgehog signaling and preventing or treating cancer.
8759317 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as...
8759308 RNAi probes targeting cancer-related proteins  
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder...
8759289 Method for sensitizing cancer stem cells to cancer therapy  
Disclosed herein are compositions and methods useful for the treatment of cancer, such as breast cancer. In some embodiments, the methods and compositions include human prolactin, or human...
8759006 PSCA: prostate stem cell antigen and distinguishing androgen receptor negative prostate cancer from benign prostatic hyperplasia  
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high...
8758835 Composition useful for the prevention or reduction of the progression of prostate cancer  
It is described a composition comprising as active ingredients green tea extract and pomegranate extract for the prevention or reduction of the progression of prostate cancer.
8756711 Method for staging cancer progression by AFM  
The present invention relates to a method for classifying a tissue biopsy sample obtained from a tumor, comprising determining a plurality of stiffness values for said sample by measuring a...
8754230 4-pyridinone compounds and their use for cancer  
Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or...
8754094 Methods for heat shock protein dependent cancer treatment  
The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective...
8754086 Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer  
The disclosure describes compounds of formula I, wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and...
8754078 Compositions and methods for treatment of cancer  
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides methods of treating a cell...
8754046 MHC class II restricted T cell epitopes from the cancer anitgen, NY ESO-1  
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are...
8754035 Compositions and methods for visualizing and eliminating cancer stem cells  
The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with...
8753892 Phosphodiesterase 4D7 as prostate cancer marker  
The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for prostate cancer, and the use of PDE4D7 as a marker for diagnosing, detecting, monitoring or prognosticating...
8753630 Using EGFRvIII to identify and target cancer stem cells  
A set of markers for cancer stem cells are provided. The cells can be prospectively isolated or identified from primary tumor samples, and possess the unique properties of cancer stem cells in...
8753604 Methods and compositions for synaphically-targeted treatment for cancer  
Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to...
8748484 Organometallic anti-cancer complexes  
An anti-cancer ruthenium complex containing organometallic triruthenium with two maltol ligands is claimed.
8748470 Methods for treating ovarian cancer by inhibiting fatty acid binding proteins  
The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.
8748423 Compositions and methods for the prevention and treatment of cancer  
The invention relates to compositions and methods for the treatment and prevention of cancer and other cell proliferative disorders.
8748405 Methods and compositions for the treatment of cancer or other diseases  
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to...
8748389 Treating cancer  
The present invention provides a peptide comprising an amino acid sequence that is part of the amino acid sequence of CDK4 protein, or homologous to part of the amino acid sequence of CDK4...
8748118 Urinary biomarkers for cancer diagnosis  
The present invention is directed to the field of cancer diagnosis, specifically to the diagnosis of bladder cancer (BC) and prostate cancer (CaP). More specifically, the invention provides...
8748113 Methods for detecting and monitoring circulating cancer stem cells  
Provided herein are compositions, methods, and kits useful for detecting whether a subject has or is likely to develop a cancer and for monitoring, staging and examining a cancer patient. Also...
8748112 Methods of determining cancer cell responsiveness to a notch inhibitory agent  
The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also...
8747867 Cancer markers  
The invention relates to methods of diagnosis and prognosis of cancer, and in particular NSCLC, the methods comprising determining the expression level of one or more genes. In some embodiments...
8747837 Oncolytic vaccinia virus combination cancer therapy  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia...
8747833 B7-H1 and methods of diagnosis, prognosis, and treatment of cancer  
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere...
8742141 Inhibition and treatment of prostate cancer metastasis  
The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods...
8742083 Panel of micrornas that silence the MCL-1 gene and sensitize cancer cells to ABT-263  
MicroRNAs (miRNAs) that sensitize cancer cells to Bcl-2 family protein inhibitors are identified and described. Oligonucleotide panels, arrays and methods using the sensitizing miRNAs are also...
8741967 Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer  
The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes...
8741903 Organic compound for use in the treatment of hepatocellular cancer (HCC)  
The present invention relates to the method of treating hepatocellular cancer (HCC) with 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidaz ol-2-yl]-1H-quinolin-2-one or a...
8741889 Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor  
The present invention provides a method for treating a patient having cancer comprising administering to the patient a therapeutically effective amount of compound (1), or a pharmaceutically...
8741811 Detection of genetic or molecular aberrations associated with cancer  
Biological samples including cell-free DNA fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and/or amplifications in a tumor. Multiple loci are used for...
8741641 Methods for evaluating the stage of ovarian cancer or the survival rate of an ovarian cancer patient  
An object of the present invention is to provide a method for detecting cancer through identification of genes exhibiting characteristic behavior in the cases of cancer such as ovarian cancer, and...
8741637 Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties  
The invention relates to the use of encapsulates of cancer cells, in agarose coated, agarose containing beads, for isolating chemotherapeutic resistant cells which have at least one stem cell...
8741605 Gene expression markers for breast cancer prognosis  
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
8741594 Mitochondrial enoyl coenzyme A hydratase 1 as marker for diagnosing stomach cancer  
The present invention relates to mitochondrial protein that can be used as a marker for diagnosing stomach cancer. According to the present invention, the marker for diagnosing stomach cancer...
8741587 ARMET as a marker for cancer  
Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of...
8741582 Detection of a specific DEK isoform as a urine-based biomarker for bladder cancer  
The present invention is directed to a method of detecting a DEK protein isoform 2 in a human urine sample using ELISA. Methods and compositions for detection of DEK isoform 2 in human urine are...
8741581 Markers for cancer detection  
The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting...
8741574 Gene expression signature of genomic instability in breast cancer  
Methods of assessing genomic instability in breast cancer tissue by measuring the expression level of genes CDKN2A, SCYA18, STK15, NXF1, cDNA Dkfzp762M127, p28 KIAA0882, MYB, Human clone 23948,...