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8986672 Use of mutant Herpes Simplex Virus-2 for cancer therapy  
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic...
8981075 PSA binding aptamer and method for diagnosis of prostate cancer  
The present invention provides an aptamer that binds to prostate-specific antigen (PSA), the aptamer including: a preceding region having a random polynucleotide sequence consisting of from 1 to...
8980934 Kinase inhibitors and method of treating cancer with same  
The present teachings provide a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use...
8980933 Combretastatin analogs for use in the treatment of cancer  
The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the...
8980932 Cancer targeting using carbonic anhydrase isoform IX inhibitors  
The present invention concerns novel carbonic anhydrase IX inhibitors comprising a nitroimidazole moiety and their use in therapy of hypoxic conditions, in particular cancer treatment, especially...
8980638 Use of IMP3 as a prognostic marker for cancer  
Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a...
8980637 Breast cancer biomarkers and identification methods using NMR and gas chromatography-mass spectrometry  
A method for the parallel identification of one or more metabolite species within a biological sample is provided. The method comprises producing a first spectrum by subjecting the sample to a...
8980573 Method for providing diagnosis of cancer using seprase as a marker  
The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different...
8980571 Method of identifying a candidate compound which may inhibit α9-nAchR overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells  
The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or α9-nAChR overexpression and proliferation of...
8980570 Composition for cancer prognosis prediction comprising anti-TMAP/CKAP2 antibodies  
The present invention relates to an antibody which specifically binds to TMAP (tumor associated microtubule associated protein)/CKAP2 (cytoskeleton associated protein 2) or a fragment thereof, and...
8980557 Marker for determination of sensitivity to triplet combination anti-cancer agent  
To provide a marker for determining sensitivity of a patient to an anti-cancer agent, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and...
8980554 Genetic make-up modifies cancer outcome  
A frequent SNP A259G (K87E) genotype switch in the MMP8 gene in has been found to modify the clinical behavior of cancers. The modification varies based on the patient's genotype for the SNP, and...
8980269 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8980268 Methods for treating cancer by administering an anti-Ang-2 antibody  
The present invention provides antibodies that bind to angiopoietin-2 (Ang-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human...
8980246 Oncolytic vaccinia virus cancer therapy  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations....
8977346 Mechanism of quantitative dual-spectrum IR imaging system for breast cancer  
A mechanism of quantitative dual-spectrum IR imaging (QDS-IR) system for examining the breast cancer is reported. The major mechanism of the system is a pair of long-wave Infra-red (LIR) and...
8977019 Methods for microcalcification detection of breast cancer on digital tomosynthesis mammograms  
A computer-aided detection system to detect clustered microcalcifications in digital breast tomosynthesis (DBT) is disclosed. The system performs detection in 2D images and a reconstructed 3D...
8975379 Identification of cancer protein biomarkers using proteomic techniques  
The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to...
8975377 Cancer treatment using humanized antibodies that bind to EphB4  
In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes.
8975274 Compositions and methods for treating cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
8975248 Combinations of therapeutic agents for treating cancer  
A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treated with a camptothecin...
8975086 Method for treating or preventing bladder cancer using the DEPDC1 polypeptide  
The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The...
8975071 Compositions for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
8975030 Method for cancer detection  
The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence, status or metastasis of cancer by detecting plasma Hsp90α having...
8975029 Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation  
The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject,...
8974802 Medicament for the treatment of cancer of the pancreas  
The invention relates to a suspension of red corpuscles encapsulating asparaginase as a medicament for treating pancreatic cancer. It in particular concerns a therapeutic composition or medicament...
8974784 Anti-pancreatic cancer antibodies  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies...
8974777 Adenovirus with mutations in the endoplasmic reticulum retention domain of the E3-19K protein and their use in cancer treatment  
The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant...
8969527 Recurrent gene fusions in prostate cancer  
Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and...
8969396 Method for treating a B-raf associated cancer with an Hsp90 inhibitor  
The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated...
8969372 Aryl imidazoles and their use as anti-cancer agents  
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone...
8969304 Compositions and methods for the prevention of cancer in high risk patients  
This relates to the prevention of cancer initiation. More specifically, the invention provides compositions and methods useful for altering the genetic signature in breast tissue, said alteration...
8969040 Pharmaceutical agent comprising anti-BMP9 antibody as active ingredient for treatment of anemia such as renal anemia and cancer anemia  
The present invention provides an anti-BMP9 (Bone morphogenetic protein-9) monoclonal antibody or an antibody fragment thereof binding to human BMP9, a hybridoma producing the antibody or the...
8969001 Materials and methods for predicting recurrence of non-small cell lung cancer  
Disclosed herein is a DNA methylation-based test for determining the recurrence or non-recurrence of a lung cancer such as NSCLC after treatment. The assays involve the detection of methylation of...
8969000 Prognostic gene expression signature for non small cell lung cancer patients  
The invention relates to a method of typing non-small cell lung cancer by determining RNA levels for a set of genes. The typing can be used for determining a metastasizing potential of the cancer...
8968745 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8968173 Methods to arrest cancer cell growth and proliferation using electromagnetic energy delivered via electromagnetic coil systems  
A non-invasive method of using electromagnetic field energies to reduce or arrest the growth rate and proliferation of cancer cells, and induce apoptosis in cancer cells, and reduce or arrest the...
8965527 Method and apparatus for treating cancer  
A method and apparatus for treating masses, such as prostate or breast cancer, or any other soft tissue cancerous or benign mass, employs a unique, three-dimensional software-controlled electronic...
8963112 Charged particle cancer therapy patient positioning method and apparatus  
The invention comprises a patient positioning and/or repositioning system, such as a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in...
8962679 Daidzein analogs as treatment for cancer  
Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer...
8962670 Anti-cancer agents  
Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and...
8962655 Composition for treatment of undifferentiated gastric cancer  
Disclosed are: a therapeutic agent, a kit and a treatment method for undifferentiated gastric cancer; and a pharmaceutical composition, a kit and a treatment method which are more effective on a...
8962593 GLA monotherapy for use in cancer treatment  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
8962591 Compositions and methods for treating cancer  
This invention generally relates to compositions and methods for targeted delivery of chemotherapeutic agents to cancerous and pre-cancerous cells, thereby treating a cancer in a subject.
8962590 Prostate cancer vaccine  
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer....
8962268 Method for determining survival prognosis of patients suffering from non-small cell lung cancer (NSCLC)  
The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods...
8962267 Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy  
The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also...
8962236 Epigenetic biomarker ADAMTS9 for diagnosis and prognosis of gastric cancer  
The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the ADAMTS9 gene, which in some cases is due...
8962011 Process and intra-cervical device for the local release of drugs in the local-regional treatment of cervical cancer  
An intrauterine device and more specifically an intracervical device (ICD) for the local release of drugs in the loco-regional treatment of tumours of the uterine cervix comprises an elongated...
8961982 Modulation of developmental immune programming and protection against cardiovascular disease, diabetes, infectious diseases, and cancer  
Maternal adaptive immunity conveys temporary humoral immune protection to neonates. The disclosure demonstrates the influence of the in utero environment on adult atherosclerosis and provides...