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8350036 Bisnaphthalimidopropyl derivative compounds with anti-parasite and anti-cancer activity  
The present invention relates to chemical compounds with anti-cancer and anti-parasite activity. The invention relates, above all, to novel bisnaphthalimidopropyl derivatives with specific...
8349853 Compositions and methods of treatment of cancer  
This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact (e.g., bind to) with MUC1 growth factor receptor or its...
8349847 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents  
The invention relates to substituted pyrazolo[3,4-d]pyrimidine derivatives of the Formula-(I), or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as...
8349834 Dioxolane derivates for the treatment of cancer  
This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said...
8349832 Compounds and compositions for treating cancer  
The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of...
8349822 Treatment of cancer with bio and chemotherapy  
This invention relates to compositions and methods utilizing a chemotherapeutic drug and 6-bromoindirubin3′-oxime (BIO) for the treatment of cancer, including glioblastoma multiforme. The present i...
8349579 Galectin-3 cleavage as a marker for matrix metalloproteinase activity in cancer  
Provided are differential antibodies recognizing the cleaved and non-cleaved forms of matrix metalloproteinases (MMPs), and methods of using the antibodies as surrogate diagnostic markers for the...
8349568 Method of diagnosing poor survival prognosis colon cancer using let-7g  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8349555 Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures  
The emerging concept of cancer stem cells suggests that activation in transformed cells of “stemness” genetic pathways (e.g., normal stem cells' self-renewal pathways) may contribute to the sur...
8349360 Liposomes with improved drug retention for treatment of cancer  
The present invention relates to the use of copper ions to achieve enhanced retention of a therapeutic agent within a liposome. The invention may be employed to more effectively deliver a...
8344113 Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer  
The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell...
8344020 Use of fusarochromanone and its derivatives in the diagnosis and treatment of cancer and other diseases  
A method of photodynamic therapy to treat diseased cells in an animal is generally provided. According to the method,...
8343967 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
8343943 Cancer sensitizer comprising glucosamine, glucosamine derivatives or salts thereof  
Disclosed herein is a cancer sensitizer comprising glucosamine, a glucosamine derivative, or a salt thereof. When administered to patients with cancer, the cancer sensitizer functions to sensitize...
8343940 Method for enhancing chemical sensitivity or radiosensitivity of cancer cells by inhibiting expression of TSPYL5  
Disclosed herein is a method for enhancing sensitivity of cancer cells to compounds or radiation by inhibiting the expression of testis-specific protein, Y-encoded like 5 (TSPYL5). More...
8343919 Cancer treatment using natriuretic peptides  
The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the...
8343738 Assay for screening for potential cervical cancer  
The invention relates to an assay for determining a health state of a subject using a combination of detecting the presence of a virus and detecting the presence of a genomic target or marker...
8343725 Method of diagnosing poor survival prognosis colon cancer using miR-10a  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8343719 Microrna as biomarker in cancer  
The present invention relates to the discovery of certain microRNAs that correlate with certain information regarding cancer. The microRNAs of the invention are selected from the group consisting...
8343461 Molecular signature of cancer  
The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
RE43899 Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents  
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for...
8340745 Methods for characterizing cancer and pre-cancer tissues  
A quantitative method for determining tissue characteristics includes the steps of generating data for a dynamic optical curve over a period of time based on an optical property of a tissue, or...
8338594 Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase  
This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making...
8338481 Alkoxyalkyl S-prenylthiosalicylates for treatment of cancer  
Disclosed are alkoxyalkyl S-prenylthiosalicylates and pharmaceutical compositions containing the same and a pharmaceutically acceptable carrier. Methods for treating a human afflicted with cancer,...
8338473 Derivatives of psammaplin A, a method for their synthesis and their uses for the prevention or treatment of cancer  
Derivatives of psammaplin A responding to formula (I), a method for their synthesis and their use for the preparation of a medicament for preventing and for treating a tumor or a cancer. Formula (I).
8338466 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
8338383 Use of immunomodulators for the treatment of cancer  
A method for treating a cancer, by determining a patient to have an ECOG (Eastern Cooperative Oncology Group) score of 0 or 1 and selecting that patient for treatment, and administering to the...
8338109 Predicting cancer outcome  
This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine...
8338106 Method of diagnosing poor survival prognosis colon cancer using miR-29a  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8338105 Method of diagnosing poor survival prognosis colon cancer using miR-203  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8338104 Method of diagnosing poor survival prognosis colon cancer using miR-103-2  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8338103 Method of diagnosing poor survival prognosis colon cancer using miR-106a  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8338102 Method of diagnosing poor survival prognosis colon cancer using miR-181b  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8337851 Methods of monitoring the efficacy of anti-CD40 antibodies in treating a subject for a CD40-expressing cancer  
Methods for identifying subjects having a cancer or pre-malignant condition that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods...
8337843 Treatment of metastatic breast cancer  
The present invention relates to the use of an anti-EpCAM antibody for the manufacture of a medicament for the treatment of metastatic breast cancer. The present invention further relates to a...
8337838 Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders  
Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as...
8334398 Compounds and methods for the treatment of cancer  
The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin,...
8334311 Indoline anti-cancer agents  
Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
8329881 Metastatic colorectal cancer vaccine  
The invention relates to prophylactic and therapeutic vaccines for protecting individuals against metastatic colorectal cancer and for treating individuals who are suffering from metastatic...
8329879 H3LMN compound used as radioactive agent for treatment of liver cancer and manufacturing method thereof  
H3LMN series compounds used as radioactive agents for treatment of liver cancer and a manufacturing method thereof are revealed. 2-thioethylamine hydrochloride is reacted with triphenylmethanol for...
8329756 Drug for treatment of colon cancer  
The invention provides a method for treating or ameliorating colon cancer in a mammal comprising administering to the mammal a therapeutically effective amount of one or more compounds selected...
8329666 Compositions and methods for treating cancer  
Provided herein are methods of treating cancer comprising administering decitabine in combination with compounds that inhibit the deamination enzyme responsible for the inactivation of decitabine.
8329665 Compositions and methods for treating cancer  
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
8329657 Fn14/TRAIL fusion proteins and method of treating cancer  
Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as...
8329408 Methods for prognosis and monitoring cancer therapy  
The present invention also relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment....
8329164 Methods and compositions concerning poxviruses and cancer  
The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more...
8324282 Alkylating agent combinations in the treatment of cancer  
This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic...
8324280 Treatment of prostate cancer with DDC inhibitor  
Prostate cancer comes in various forms and has proven difficult to treat. Provided herein are various methods and compositions for treating all forms of prostate cancers with dopa decarboxylase...
8324194 Combination therapy for the treatment of cancer  
The present invention provides methods of treating cancer comprising treating a patient in need thereof with hormone therapy and administering to the patient a therapeutically effective amount of...
8324188 Combinations of ET-18-O-CH3and anti-cancer agents for the treatment of cancer  
A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic...