Match Document Document Title
9370560 Vaccine for the prevention of breast cancer relapse  
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining...
9370554 Method for treating breast cancer with prolactin receptor agonists  
Disclosed herein are compositions and methods useful for the treatment of cancer, such as breast cancer. In some embodiments, the methods and compositions include human prolactin, or human...
9370551 Compositions and methods of treating head and neck cancer  
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features...
9370526 Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer  
A combination hormone and melatonin therapy is provided to reduce the risk of developing, or to reduce the severity of, breast cancer by administering at least one estrogen hormone and optionally...
9370521 Targeting GLI proteins in human cancer by small molecules  
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and...
9370489 Combinational liposome compositions for cancer therapy  
The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome...
9365903 Compositions comprising polynucleotides for detecting lung cancer  
Methods of detecting lung cancer, such as non-small cell lung cancer, including squamous cell carcinoma and adenocarcinoma, are provided. Methods of detecting changes in the levels of one or more...
9365900 Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene  
The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and...
9365641 Compositions and methods for targeting stromal cells for the treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in...
9365640 Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor  
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
9365599 N3S1 chelator-folate derivatives, preparation method thereof and composition for diagnosis or treatment of cancer containing the same as an active ingredient  
Novel N3S1 chelator-folate derivatives, a preparation method thereof, and a composition for diagnosis and treatment of tumor including the same as an active ingredient are provided. The novel N3S1...
9364566 Aqueous formulation for selective targeting and delivering gene to cancer cells  
The present invention relates to a cationic lipid based aqueous formulation comprising cationic lipid, dexamethasone and a neutral co-lipid, wherein the said formulation is useful for selective...
9364500 Compositions for treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances  
A method for treating cancer is described using combination therapies comprising the use of hyperbaric oxygen with histone deacetylase inhibitors, with and without glycolytic therapies. The...
9364480 Pharmaceutical composition for preventing or treating cancer, containing enoblock as active ingredient  
The present invention relates to ENOblock, which is a non-substrate analog having an enolase inhibitory activity, and a pharmaceutical composition for preventing or treating cancer or...
9364477 Mutant ROS expression in human cancer  
The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein...
9364473 Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan  
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the...
9364469 Identification of a new AMPK activator for treatment of lung cancer  
The present invention discloses a method of treating gefitinib-resistant non-small-cell lung cancer, comprising administering an effective amount of D561-0775. A pharmaceutical composition...
9362094 Biomarkers for determining breast cancer bone metastasis  
The invention provides biomarkers and biomarker profiles that discriminate between a subject with breast cancer that has metastasized to the bone and a subject with breast cancer that has not...
9360487 Multiplex MRM assay for evaluation of cancer  
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (ER), progesterone receptor (PR), and/or antigen Ki67 (Ki67)...
9360481 Predictive biomarker for cancer treatment with ADCC-enhanced antibodies  
The present invention is directed to methods for identifying which patients diagnosed with cancer will most benefit from treatment with an anti-cancer therapy comprising an ADCC-enhanced antibody.
9359648 Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein  
A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the...
9359646 Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene  
The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and...
9359606 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Anti-clusterin monotherapy for cancer treatment
 
The present invention provides a method of treating cancer in a subject afflicted with cancer comprising administering to the subject an anti-clusterin oligonucleotide as a monotherapy to treat...
9359605 Method of treating cancer by inhibition of DNA repair proteins  
Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense oligonucleotides can be used...
9359436 Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies  
The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the invention are a pharmaceutical...
9359423 Protein involved in detection of cancer metastasis and a treatment thereof  
Using phosphoproteomics, we profiled the phosphorylation levels of hundreds of proteins concurrently across an isogenic model of breast cancer metastasis. Among them is TRPV4, a calcium channel...
9359299 Small molecules for treating breast cancer  
Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.
9359279 Treatment of cancer, inflammatory disease, and autoimmune disease  
A method of treating cancer, inflammatory disease, and autoimmune disease by administering to a subject in need thereof an effective amount of one or more 1,5-dipenylpenta-1,4-dien-3-one...
9358308 Compositions of a peptide targeting system for treating cancer  
This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to...
9358289 Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies  
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the...
9358288 Antibody combinations and use of same for treating cancer  
A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and...
9358247 Methods and compositions for promoting activity of anti-cancer therapies  
The present invention relates to a method of inhibiting growth of a cancerous cell. The method includes the step of exposing the cancerous cell to an anti-cancer therapy and an effective amount of...
9358232 Methods for treating cancer using TOR kinase inhibitor combination therapy  
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of...
9355445 Breast cancer pathological image diagnosis support system, breast cancer pathological image diagnosis support method, and recording medium recording breast cancer pathological image diagnosis support program  
A breast cancer pathological image diagnosis support system for supporting a diagnosis of breast cancer based on a pathological image is provided. The breast cancer pathological image diagnosis...
9354232 PODXL in bladder cancer  
There is provided a method for determining whether a mammalian subject having a bladder cancer belongs to a first or a second group, wherein the prognosis of subjects of the second group is worse...
9354224 Methods and compositions for the diagnosis of cancer susceptibilities and defective DNA repair mechanisms and treatment thereof  
Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been...
9353416 Gene relating to estimation of postoperative prognosis for breast cancer  
It is intended to provide a system of predicting the postoperative prognosis in a patient with breast cancer from the viewpoint of gene expression based on the data obtained by genome-wide and...
9353150 Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment  
The present application provides, among other things, a compound of Formula I-a and/or I-b, or a pharmaceutically acceptable salt thereof, wherein the variables are defined in the specification....
9353140 BQC-G, a tumor-selective anti-cancer prodrug  
The invention relates to the synthesis of a second-generation camptothecin glucuronide prodrug (BQC-G) of a potent anticancer camptothecin derivative 5,6-dihydro-4H-benzo[de]quinoline-camptothecin...
9353132 Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer  
The present disclosure relates to boron-based 4-hydroxytamoxifen and endoxifen prodrugs and the synthesis of the same. Further, the present disclosure teaches the utilization of the boron-based...
9353121 Anti-cancer compounds targeting Ral GTPases and methods of using the same  
The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral...
9353119 Composition for preventing and treating non-small cell lung cancer, containing pyrazino-triazine derivatives  
Disclosed is a composition comprising a pyrazino-triazine derivative, an isomer thereof or a pharmaceutically acceptable salt thereof. It is very effective for preventing and treating NSCLC.
9352039 Method of reducing the number of EMT and MET type breast cancer stem cells  
Compositions, kits, and methods for therapeutic screening, diagnostics, and cancer treatment based on the identification or use of the different states of cancer stem cells, including cancer stem...
9352028 Composition for treating lung cancer, particularly of non-small lung cancers (NSCLC)  
The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of...
9351997 Method of treating cancer  
The invention provides a method for treating cancer using a coadministration strategy that combines local codelivery of a therapeutic agent and an intracellular penetration enhancing agent, and...
9351981 Use of PKC-iota inhibitors for the treatment of breast cancer  
The subject invention pertains to uses of PKC-iota inhibitors for treatment of breast cancer. In one embodiment, the subject invention provides novel uses of 1H-imidazole-4-carboxamide,...
9351977 Methods of reducing mammographic breast density and/or breast cancer risk  
The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a premenopausal or perimenopausal...
9351974 Substituted pteridinones for the treatment of cancer  
Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including...
9351964 Methods for treating cancer and non-neoplastic conditions  
Compounds, such as compounds of Formula (I), that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are...
9347945 Methods and marker combinations for screening for predisposition to lung cancer  
The present invention relates to rapid, sensitive methods for determining whether a subject is at risk of developing lung cancer or has lung cancer based on certain combinations or biomarkers or...