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8486939 Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy  
Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or...
8486903 TAZ/WWTR1 for diagnosis and treatment of cancer  
We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to...
8486656 Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine  
Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the...
8486648 Methods of detecting ovarian cancer  
The present invention provides methods of detecting ovarian cancer using biomarkers.
8486641 Compositions and methods for diagnosing and treating prostate cancer  
A method of diagnosing and determining a predisposition to prostate cancer is provided. The method comprising determining levels of MCP-1 antibodies and PSA in a sample of a subject and comparing...
8486413 Immunological compositions as cancer therapeutics  
The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In...
8486391 Cancer treatment kits using antibodies to aminophospholipids  
Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor...
8486382 Method for treating cervical cancer  
Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or...
8486127 High temperature thermal therapy of breast cancer  
A method is described for preventing breast cancer recurrence after surgical removal of a breast cancer mass. Specifically, the method is thermal treatment of breast tissue surrounding a cavity...
8481760 Inhibition and treatment of prostate cancer metastasis  
The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods...
8481740 Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture  
This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and...
8481572 Pharmaceutical compositions and methods for the treatment of cancer  
Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a...
8481533 Kinase inhibitors and method of treating cancer  
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase...
8481529 Combination cancer chemotherapy  
Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective...
8481525 Kinase inhibitors and method of treating cancer with same  
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase...
8481503 Combination cancer therapy with an AKT inhibitor and other anticancer agents  
The invention relates to combination anticancer therapy with certain Akt inhibitor and other anticancer agents such as anticancer antimetabolites, anticancer antibiotics, plant-derived anticancer...
8481497 Therapeutic agent for cancer, and method for treatment of cancer  
[PROBLEMS] To provide a technique which enables an effective antibody therapy for cancer which targets for FGFR1 without the need of using any effective antibody having high specificity and a...
8481481 Peptides and their use as carriers into cancer cells  
The use of a peptide is described as a carrier for the transport of molecules or radioisotopes into cancer cells; also described are modifications of said peptide and their use.
8481279 Methods of treating lung cancer using inhibitors anaplastic lymphoma kinase  
In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of...
8481275 Method of detecting pancreatic cancer  
To provide a method of accurately detecting pathological haptoglobin using a lectin having strong affinity and high specificity for fucose. The method of the present invention for detecting...
8481271 Vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method  
The present invention relates to the prognosis of the outcome of a cancer in a patient, which prognosis is based on the quantification of one or several biological markers that are indicative of...
8481256 In vitro method for identifying compounds for cancer therapy  
The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder...
8481038 Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins  
The present invention provides methods of treating a patient having a cancer comprising administering to the patient a soluble Fibroblast Growth Factor Receptor 1 (FGFR1) fusion protein such as an...
8481001 Combination therapies comprising quinoxaline inhibitors of P13K-alpha for use in the treatment of cancer  
The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination...
8480407 Tissue-mimicking phantom for prostate cancer brachytherapy  
A phantom for prostate cancer brachytherapy has a prostate tissue phantom shaped like a real prostate gland, a perineal tissue phantom surrounding the prostate tissue phantom, a skin tissue phantom...
8477903 Validating a compensator for use in a radiation therapy machine to treat a cancer patient  
A method of validating a compensator for use in a radiation therapy machine to treat a cancer patient involves determining a radiation treatment plan based on a compensator description file that...
8476582 Device for measuring radiation intensity of small sealed radioactive source for cancer therapy  
A radiation intensity measuring apparatus is provided for an encapsulated sealed radioactive source for brachytherapy, which is capable of measuring radiation intensity of sources with a cartridge...
8476303 N-aminopyrrolylmethyltetrahydropyridines as anti-cancer agents  
The compounds herein disclosed are N-aminopyrrolylmethyltetrahydropyridine analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These...
8476285 Purine-core inhibitors of HSP90 and their use in treating cancer  
The invention relates to compounds of Formulae I-III: and therapeutic uses thereof, wherein A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; B...
8476237 Compositions and methods for treating cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and...
8476074 Specific gene polymorphisms in breast cancer diagnosis, prevention and treatment  
A method for detecting a predisposition to breast cancer in a subject is provided. The method includes detecting in a biological sample from the subject one or more polymorphisms in the sequence of...
8476033 Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer  
Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel...
8476026 Biomarkers of ovarian cancer  
The invention is directed to assays for biomarkers associated with ovarian cancer that can be used diagnostically. It includes glass or plastic plates or slides on which the biomarkers have been...
8475814 Prevention and treatment of breast cancer with 4-hydroxy tamoxifen  
Pharmaceutical compositions of 4-hydroxy tamoxifen, particularly compositions suitable for percutaneous administration, are useful in methods for treating and preventing breast cancer. When...
8475785 Allogeneic cancer cell-based immunotherapy  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
8475377 Multi-modality breast cancer test system  
A multi-modality breast cancer test assembly (20) of the type for detecting the position of potential breast cancer by performing thermography and optical spectroscopy and ultrasound tests (64). A...
8472752 Method of detecting cancer in a single cell using mitochondrial correlation microscopy  
A method for distinguishing a normal cell from an abnormal cell, such as, for example a cancer cell or diseased cell, of the same tissue type using mitochondrial correlation microscopy.
8470989 CTSP cancer-testis antigens  
The invention relates to CTSP polypeptides and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments...
8470971 Cell permeable p53 recombinant protein, polynucleotide encoding the same, and anti-cancer composition containing the same as active ingredient  
Disclosed are a cell-permeable p53 recombinant protein in which a macromolecule transduction domain (MTD) is fused to the tumor suppressor p53, a polynucleotide encoding the same, a recombinant...
8470888 Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer  
Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a...
8470817 Compounds and methods for treatment of cancer  
Compounds for treating, preventing or managing cancer are disclosed. Also provided are methods for using the compounds in treatment of various cancers. Also provided are methods of treatment using...
8470815 Nitrofuran compounds for the treatment of cancer and angiogenesis  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
8470798 Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associated genes  
The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation....
8470796 Treatment of cancer by inhibition of IGFBPs and clusterin  
Agents that reduce the amount of IGFBP-2 and/or IGFBP-5 and that are known to be useful in the treatment of cancer result in increased expression of the protein clusterin. Since clusterin can...
8470785 Method for treating ocular cancer  
Compositions and methods for treating ocular cancer are provided. The composition is a subconjunctival formulation of nutlin-3 and its analogs. The composition provides for methods of treating...
8470534 Methods of predicting resistance or sensitivity to therapies for cancer  
The present application is directed to methods of predicting the resistance of a tumor to molecularly targeted therapy and methods of predicting sensitivity of a tumor to DNA damaging therapy. The...
8470326 Monoclonal antibody therapy for pancreas cancer  
The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively...
8470295 Methods of treatment of androgenic steroidal hormone dependent cancer with auger electron-emitting nucleoside analogs  
A method is provided for treatment of disorders involving hyperproliferative cells, such as malignancies, advanced stage solid tumors like glioblastoma multiforme, and non-malignant...
8466151 Compounds and method for treatment of cancer  
The invention relates to a compound of Formula (I) and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein X is...
8466147 Use of reversine and analogs for treatment of cancer  
Herein is provided methods and compositions for treating cancer. In one embodiment, a method is provided for treating a patient suffering from cancer, the method comprising administering to the...