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8545812 Transport agents for crossing the blood-brain barrier and into brain cancer cells and methods of use thereof  
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished...
8541544 Molecular marker for cancer stem cell  
A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of...
8541467 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ  
The present invention refers to the use of the compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of h...
8541433 Combination comprising macitentan and paclitaxel for treating multi-drug resistant ovarian cancer  
The invention relates to the combination of an endothelin receptor antagonist of formula (I) with paclitaxel, and in particular to this combination for therapeutic use, simultaneously, separately...
8541390 Treatment of cancer by inhibition of IGFBPs and clusterin  
Agents that reduce the amount of IGFBP-2 and/or IGFBP-5 and that are known to be useful in the treatment of cancer result in increased expression of the protein clusterin. Since clusterin can...
8541382 Cardiac glycoside analogs in combination with emodin for cancer therapy  
A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a...
8541186 Cancer detection methods and techniques  
A method is provided for detecting and/or measuring the occurrence of an enzyme in the form of CYP1B1 in a patient for the detection of cancer in said patient. The method includes the steps of...
8541169 Prostate cancer-specific alternations in ERG gene expression and detection and treatment methods based on those alterations  
The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The...
8540998 Methods for treating cancer using ephrin type-A receptor 10 antibodies conjugated to cytotoxic agents  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer,...
8540989 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
8540968 Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof  
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting...
8540964 Polyvalent conjugate vaccine for cancer  
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated...
8535929 Parvovirus having a CPG-enriched genome useful for cancer therapy  
A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of...
8535678 Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders  
Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the...
8535677 Antibody drug conjugate treatment of colorectal cancer  
The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer...
8535674 Treating breast cancer and inhibiting cancer-associated bone loss with anti-IL-20 antibody  
Use of an anti-IL-20 antibody, either alone or in combination with an anti-RANKL antibody, for treating breast cancer and inhibiting cancer-associated bone loss.
8535670 Method of treating colorectal cancer tumor  
The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are...
8530659 Pharmaceutical composition containing cyclometalated N-heterocyclic carbene complexes for cancer treatment  
The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene...
8530650 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer  
The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological...
8530496 Compositions and methods for treating cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
8530437 Methods for treating cancer using herpes simplex virus expressing antisense to the squamous cell carcinoma related oncogene  
An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus...
8530428 Treating cancer with granulocyte-macrophage colony stimulating factor  
Methods for treating cancer (e.g., metastatic cancer to the lung or chronic lymphocytic leukemia) in patients are described that include administrating an aerosolized granulocyte macrophage colony...
8530421 Isolated polypeptides used for treatment of inflammatory diseases and inhibiting cancer metastasis  
The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX(or XG), which are a...
8530404 Compounds and methods for treatment of cancer  
The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor...
8530179 Electrochemical methods of detecting cancer with 4-aminophenyl phosphate  
A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell which is suspicious of a cancerous or undifferentiated phenotype with 4-aminophenyl phosphate (p-APP)...
8530151 Localization of human cytomegalovirus nucleic acids and proteins in human cancer cells  
The present disclosure shows human cytomegalovirus (HCMV) is strongly associated with a variety of cancers in humans. In addition, the present disclosure shows a specific strain of HCMV, HDu, is...
8529900 Methods for the treatment, the prognostic assessment and the staging of non-small cell lung cancer  
The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer.
8526698 Method and apparatus for ductal tube tracking imaging for breast cancer detection and diagnosis, and product  
A method apparatus and computer product for imaging a human breast to map the breast ductal tree is disclosed. First, a breast is diffusion tensor imaged with high spatial resolution. Then the...
8524872 Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer  
A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
8524784 Polymer micelles containing anthracylines for the treatment of cancer  
The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using...
8524783 Polymer micelles containing anthracylines for the treatment of cancer  
The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using...
8524762 Thioxanthone-based autophagy inhibitor therapies to treat cancer  
The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these...
8524669 MUC-1 cytoplasmic domain peptides as inhibitors of cancer  
The invention provides for peptides from the Mucin 1 (MUC1) cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth,...
8524454 Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency  
The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention...
8524238 Cancer targets and uses thereof  
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for...
8519365 Charged particle cancer therapy imaging method and apparatus  
The invention relates to a method and apparatus for treatment of a solid tumor. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. In...
8519121 Dextran for treating lung cancer  
Dextran for preparing medicine for anti-lung cancer, has repeated structure unit and molecular weight of 1.5-2.5 million Daltons. The dextran is extracted from land slug.
8519116 Method for predicting a clinical response of a patient suffering from or at risk of developing cancer towards a given mode of treatment  
The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing cancer, preferably colorectal cancer, towards a given mode of...
8518990 Cancer treatment  
A method for treating, preventing or ameliorating a hyperliferative disease and/or disorder in a mammal, comprises administering a therapeutically effective amount of one or more compounds selected...
8518965 Compositions and methods for treating cancer  
The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial...
8518889 Method of treating cancer with antibodies against long-form leukotriene B4 receptor BLT2  
The present invention relates to the use of inhibitors of leukotriene B4 receptor BLT2 for treating human cancers. More particularly, the present invention relates to a pharmaceutical composition...
8518888 Method of treatment of gastrointestinal-type cancer with antagonistic antibodies to IL-11R  
The present invention relates generally to the field of cancer therapy. More particularly, the present invention provides a method for the treatment of gastrointestinal-type cancers and therapeutic...
8518887 Method of treating cancer with DLL4 antagonist and chemotherapeutic agent  
The invention provides methods for treating various types of cancer/tumor by administering the combination of Dll4 antagonists, in particular, Dll4 antibodies and fragments thereof that...
8518870 Compositions and methods for cancer treatment using targeted carbon nanotubes  
The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to,...
8518654 Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect  
A novel biomarker for use in lung cancer diagnosis is provided.
8518652 Truncated proteins as cancer markers  
Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are...
8518651 Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker  
It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology,...
8518650 Biomarkers for prostate cancer and methods using the same  
Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation,...
8518647 Method of diagnosing poor survival prognosis colon cancer using miR-16b  
The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon...
8513484 Fish cancer model  
The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also...