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9044432 Compositions and methods for cancer detection and treatment  
Disclosed herein are compositions and methods for cancer detection and treatment. Compounds that inhibit PRMT5 are contemplated, as are pharmaceutical compositions comprising a therapeutically...
9040671 Methods for cancer management targeting Co-029  
The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer...
9040574 Method of treating androgen independent prostate cancer  
The present invention is directed to a method treating prostate cancer. The method comprises administering to a patient in need thereof at least one compound selected from...
9040505 Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis  
Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that...
9040501 Compositions and methods for treating cancer  
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
9040497 Treatment and diagnosis of colon cancer  
The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
9040286 Diagnosis and treatment of cancer  
Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an...
9040100 Methods for inhibiting prostate cancer by kinases and angiogenesis inhibitory mechanisms of ball moss extract  
A method of treating prostate cancer by administering a pharmaceutically-acceptable amount of a crude extract of the indigenous Jamaican plant Ball Moss (Tillandsia Recurvata) comprising one or...
9040081 Use of lipid containing particles comprising Quillaja saponins for the treatment of cancer  
The present invention relates to the use of lipid containing particles, such as liposomes, iscom and/or iscom matrix and posintros, comprising at least one lipid and at least one saponin for the...
9040047 Combinations of anti ErbB antibodies for the treatment of cancer  
An article-of-manufacture is provided. The article-of-manufacture comprises a packaging material identified for treating cancer, packaging: (i) an anti-EGFR antibody comprising the CDR sequences...
9040044 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
9035036 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments  
Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will...
9034875 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9034862 Compositions and methods for the treatment of cancer  
The present invention relates to compositions, kits, and methods for treatment of cancers. In some cases, the composition comprises a platinum compound comprising a phenanthridine ligand.
9034854 Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy  
The present invention relates to a method of treating or preventing estrogen-sensitive tumors in a mammal, said method comprising the administration of a therapeutically effective amount of an...
9034828 Syndecan peptides and polypeptides as inhibitors of cancer  
The invention provides for peptides from syndecan 4 and methods of use therefor. These peptides can inhibit α6β4 integrin interaction with EGFR, thereby preventing tumor cell growth and tissue...
9034827 Syndecan peptides and polypeptides as inhibitors of cancer  
The invention provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit α4β6 interaction with HER2, thereby preventing tumor cell growth and tissue invasion.
9034588 Monoclonal antibody therapy for pancreas cancer  
The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively...
9034587 Methods of diagnosing cancer  
A method of diagnosing cancer or a pre-malignant lesion is disclosed. The method comprises determining a level of CD24 expressed on peripheral blood cells of a subject in need thereof, wherein the...
9034344 Chimeric adenoviruses for use in cancer treatment  
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
9034319 Methods of treating cancer of the central nervous system  
A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an...
9034312 Extracellular matrix compositions for the treatment of cancer  
The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are...
9034310 Interferon-statin combination cancer therapy  
A method for pharmacological treatment of cancers and other diseases is presented which includes the novel combination of a statin (Hmg-CoA reductase inhibitor, such as lovastatin, simvastatin,...
9032964 Method and system for processing cancer cell electrical signals for medical therapy  
A scientific computer system with processor capable of recording, storing, and reprogramming the natural electrical signals of cancer cells as found in tumors of humans and animals. The...
9029408 Compounds for treatment of cancer  
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a...
9029404 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9029403 Treatment of ovarian cancer with benzylidenebenzohydrazides  
Methods for inhibiting the growth of ovarian cancer cells or other serosal cancer cells are disclosed. The method involves exposing the cells to a benzylidinebenzohydrazide of formula: wherein X...
9029340 Radiation sensitization agents for prostate cancer  
Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of...
9029330 Methods of treating cancer using interleukin-12p40 variants having improved stability  
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and...
9029135 Kanamycin antisense nucleic acid for the treatment of cancer  
The invention relates to a nucleic acid comprising a sequence complementary to a fragment of the sequence coding for the kanamycin resistance protein. This nucleic acid is useful as a DNA vaccine...
9029089 Methods for predicting survival in cancer patients  
A method for survival prediction in cancer patients is provided. In one embodiment, the survival prediction is determined by the presence or absence of KRAS gene region deletion and/or loss of...
9028836 Globo H and related anti-cancer vaccines with novel glycolipid adjuvants  
An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4...
9028831 Markers for selecting personalized therapies for the treatment of cancer  
The invention relates to the identification of aprataxin (APTX) expression levels as a marker for the response to topoisomerase I inhibitor-based therapies in patients with cancer and, more...
9023993 Anti-cancer agent comprising anti-HB-EGF antibody as active ingredient  
A monoclonal antibody having a neutralizing activity on HB-EGF is disclosed. The monoclonal antibody of the present invention is preferably an antibody that does not bind to the HB-EGF protein on...
9023805 Increasing cancer patient survival time by administration of dithio-containing compounds  
The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in the time of survival in cancer patients, wherein the cancer: (i) overexpresses...
9023803 Cancer therapy based on tumor associated antigens derived from cyclin D1  
The present invention relates to cyclin D1-derived peptides for use in the improved treatment of cancer in a patient, particularly in the form of a combination therapy using a vaccine. Other...
9023598 Methods for diagnosing pancreatic cancer using miR-103-1, miR-103-2, miR-24-2 and miR-107  
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
9023395 Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics  
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic...
9023362 Immunological compositions as cancer therapeutics  
The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto....
9023338 Cancer stem cell antigen vaccines and methods  
Method of stimulating an immune response (e.g., to treat cancer) include administering to a patient a composition including dendritic cells that present cancer stem cell antigens. Compositions...
9023091 Treating cancer using electromagnetic fields in combination with photodynamic therapy  
A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is...
9023090 Treating cancer using electromagnetic fields in combination with photodynamic therapy  
A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is...
9020221 Method and apparatus for automatic cancer diagnosis scoring of tissue samples  
Certain aspects of an apparatus and method for automatic ER/PR scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying a positive stained nucleus in a...
9018601 Multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration  
The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and...
9018259 Treatment of cancer using benzoic acid derivatives  
The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are...
9018251 Method for treating brain cancer or reducing temozolomide-resistance of brain cancer cells  
Provided is a method for treating brain cancer or reducing temozolomide-resistance of brain cancer cells in a subject, comprising administrating to the subject an effective amount of an active...
9018209 Compounds and methods for the treatment of viruses and cancer  
The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl; R1 is OR1, an optionally substituted C4-12 carbocyclic group which...
9018199 Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis  
The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is covalently bound to a bioactive compound,...
9018185 Method of diagnosing cancer using a nucleolin specific aptamer  
Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease,...
9017944 Methods for the prognosis of breast cancer  
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for...