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8632777 Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen as diagnostic and therapeutic tools for prostate cancer  
Isolated monoclonal antibodies or an antigen binding portion thereof which bind to prostate specific membrane antigen in its native form occurring on the surface of tumor cells characterized in...
8629186 Polymer micelles containing anthracyclines for the treatment of cancer  
The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using...
8629174 Unifying mechanism and methods to prevent cancer and neurodegenerative diseases  
The present invention relates to methods for preventing the development of cancer or neurodegenerative diseases by administering N-Acetylcysteine (NAC), melatonin, or a combination thereof. The...
8629135 Pharmaceutical compositions comprising RET inhibitors and methods for the treatment of cancer  
A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. The compounds' ability to inhibit RET kinase is quantified, i.e., their...
8628959 Methods for cancer treatment using stem cells  
Various embodiments of the invention provide methods of treating cancer. Many embodiments provide methods of treating cancer using stem cells. In one embodiment the method comprises removing cancer...
8628920 Method for early diagnosis of liver cancer and prediction of metastasis  
Disclosed is a method for early diagnosis of liver cancer. The method comprises the steps of: (A) providing a sample obtained from a subject; (B) assessing the expression level of four subtypes of...
8628774 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
8628750 Cancer imaging and treatment  
Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a...
8627822 Semi-vertical positioning method and apparatus used in conjunction with a charged particle cancer therapy system  
The invention comprises a semi-vertical patient positioning, alignment, and/or control method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous...
RE44704 Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents  
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for...
8625739 Charged particle cancer therapy x-ray method and apparatus  
The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in...
8624027 Combination therapy for treating cancer and diagnostic assays for use therein  
The present disclosure relates to a combination of therapeutic agents for use in treating a patient a subject suffering from cancer. In addition, the present disclosure also relates to diagnostic...
8623837 Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases  
Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative...
8623667 Method for diagnosing cancer using lectin  
The present invention relates to a method for diagnosing cancer using information on aberrant glycosylation of glycoproteins, which is related with cancer progression. More particularly, the...
8623617 Detecting PAX2 for the diagnosis of breast cancer  
A method for monitoring breast conditions in a subject is disclosed. The method comprises determining a Paired Box 2 gene-to-beta defensin-1 gene (PAX2-to-DEFB1) expression ratio (the “Donald P...
8623611 Glycoprotein cancer biomarker  
The invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics.
8623604 Methods for predicting responsiveness of a cancer cell to an anti-IGFR1 antibody by analysis of mutations in PIK3CA  
The present disclosure relates generally to methods and materials for determining the responsiveness of a subject with a disease or disorder to an inhibitor of a receptor tyrosine kinase including,...
8623601 Methods of diagnosing cancer  
Provided are methods of predicting or assessing the level of severity of cancer or cancer progression in a patient comprising measuring levels of SET expression in a biological sample from a...
8623359 Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer  
The invention also relates to a composition comprising an antibody antagonist to c-Met and an aminoheteroaryl compound, particularly as a medicament. The present invention also comprises a...
8623328 Use of DKK-1 protein in the cancer diagnosis  
Use of DKK-1 protein or the nucleic acid sequence in preparation of cancer diagnostic agents or kits, method to detect liver cancer with the monoclonal antibody thereof, the kit comprising...
8618273 Partial fragment of REIC/Dkk-3 gene and cancer therapeutic agent comprising the same  
This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a...
8618096 Prodrug compositions and methods for using the same in treating cancer and malaria  
Methods and compositions for treating disease caused by increased iron levels are disclosed Fluoregenic compounds and methods of using the same are also described.
8618083 Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer  
A combination hormone and melatonin therapy is provided to reduce the risk of developing, or to reduce the severity of, breast cancer by administering at least one estrogen hormone and optionally...
8618071 Oligonucleotides for suppressing cancer cell invasion and migration  
Provided herein is a method for detection of migratory and invasive cancer cells based on a number of marker nucleic acids differentially expressed in migratory/invasive cancer cells relative to...
8618058 Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity  
The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity....
8617844 Use of cytokine receptors as biomarkers and therapeutic targets in human cancer  
Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.
8617836 Method for predicting the response of locally advanced rectal cancer to chemoradiotherapy  
The present invention relates to a method for determining or predicting the response of a patient diagnosed with locally advanced rectal cancer to chemoradiotherapy. The present invention also aims...
8617831 Methods for diagnosing and monitoring the progression of cancer by measuring soluble c-Met ectodomain  
Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.
8617818 Compositions and methods for diagnosis and prognosis of cancer and progression, and for screening anti-cancer agents  
MicroRNA (miRNA) profiling of cells showed unique miRNA signatures for each of three Akt isoforms. Among differentially regulated miRNA species, the miR-200 family was downregulated in...
8617547 Methods and compositions for diagnosing prostate cancer  
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to...
8617520 Cancer therapy  
The present invention relates to a method of preventing, treating or inhibiting the development of tumors or metastases in a subject and to an immunomodulator for use in such therapy, in...
8617514 Tumor-targeted nanodelivery systems to improve early MRI detection of cancer  
The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted...
8614554 Magnetic field control method and apparatus used in conjunction with a charged particle cancer therapy system  
The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors....
8614429 Multi-axis/multi-field charged particle cancer therapy method and apparatus  
The invention relates to method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. The...
8614339 Dimeric derivatives of artemisinin and application in anti-cancer therapy  
The present invention relates to dimeric derivatives of 10-trifluoromethylated artemisinin of formula (I) below: Formula (I) and the pharmaceutically acceptable salts thereof, and also to the...
8614304 Immunogenic peptides and methods of use for treating and preventing cancer  
Disclosed are immunogenic peptides, related fusion proteins, nucleic acids encoding the peptides or fusion proteins, conjugates, expression vectors, host cells, and antibodies. Also, disclosed are...
8614301 Methods of treating cancer using anti CD24 antibodies  
Anti-CD24 antibodies and adjuvant combinations thereof with chemotherapeutic agents or toxins, which can be used to inhibit growth of CD24-expressing cancer cells and prevent and treat cancer are...
8614290 Cancer imaging and treatment  
A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide...
8614192 Method for treating ocular cancer  
It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53...
8614095 Methods for identifying, purifying and enriching immature or stem cancer-initiating cells from tumors and use thereof  
Methods for the preparation of cell compositions based on fluorescence following excitation at wavelength of or about 488 nm and isolated cell compositions obtained therefrom wherein isolated cells...
8614093 Pharmaceutical composition for treating or preventing cancer by inducing dendritic cell-like differentiation from monocytes to improve anticancer immune activity  
According to the present invention, a composition for inducing or activating dendritic cell-like cells so as to treat or prevent cancer by immunotherapy is provided. Specifically, the following is...
8614063 Methods for screening for compounds for treating cancer  
The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate...
8614058 Molecular prognostic signature for predicting breast cancer metastasis, and uses thereof  
The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention...
8614055 Prognosis and treatment of breast cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
8613962 Prophylactic or alleviating agent for peripheral nerve disorder induced by anti-cancer agent  
There is provided a medicinal agent that is effective and highly safe for the prevention or alleviation of a peripheral nerve disorder that develops as a side effect occurring after the...
8613916 Immunotherapy for pancreatic cancer  
The present invention provides an immunotherapeutic agent and immunotherapy allowing the extension of the survival time of patients with pancreatic cancer. The immunotherapy of the present...
8613907 Compositions that inhibit proliferation of cancer cells  
Disclosed are compositions and methods for reducing the proliferation of cancer cells through targeted interactions with integrins.
8609843 Photoactive metal nitrosyls for blood pressure regulation and cancer therapy  
Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and...
8609813 Prodrug anti-cancer therapy  
Compositions and methods for inhibiting the growth of cancer cells are provided. The cancer cells, the growth of which is inhibited, have constitutively active Abl tyrosine kinase activity due to a...
8609724 Method of treating cancer using dichloroacetate  
The invention relates to the use of dichloroacetate and chemical equivalents thereof for the treatment of cancer by inducing apoptosis or reversing apoptosis-resistance in a cell Preferably, the...