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9110063 Assay methods for the determination of FKBPL expression level in the context of breast cancer  
Disclosed are methods that employ FKBPL as a marker for a subject's sensitivity to endocrine therapies in the treatment of cancers, and as a predictive marker of cancer progression and disease...
9109034 Precision medicine by targeting PD-L1 variants for treatment of cancer  
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
9108980 Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy  
Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or...
9108941 Griseofulvin analogues for the treatment of cancer by inhibition of centrosomal clustering  
The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the...
9108923 Compounds, compositions, and methods for cancer therapy  
Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed....
9108919 Compounds useful for treating cancer  
A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where: R...
9107962 Anthracycline-antibody conjugates for cancer therapy  
The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline...
9107961 Anti-DLL3 antibody drug conjugates for treating cancer  
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
9107947 Anti-cancer compositions and methods  
Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject...
9107944 Immunologically modified carbon nanotubes for cancer treatment  
A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic...
9107934 MicroRNA as a cancer progression predictor and its use for treating cancer  
The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness...
9107926 Mutant selectivity and combinations of a phosphoinositide 3-kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer  
Methods and compositions are provided for treating hyperproliferative disorders in patients with a PI3K inhibitor, GDC-0032 as a single agent or in combination with chemotherapeutic agents.
9107895 Methods and compositions for imaging cancer cells  
Disclosed are compositions comprising nanoparticles and uses thereof. Such nanoparticles include gold nanoparticles conjugated to glucose or a glucose derivative, which are useful as contrast...
9107887 Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer  
A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition,...
9107878 Methods of treating cancer  
The present invention relates to compositions and methods for treating an animal with a tumor or other metabolic disorder. In particular, the presently disclosed subject matter relates to methods...
9107863 Reagents and methods for cancer treatment and prevention  
The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or...
9107824 Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally  
One aspect of the invention relates to methods of treating cancer in a patient comprising administering intraperitoneally to a patient in need thereof a cancer treating effective amount of a...
9103833 Use of the GTPase Rab27B to diagnose and treat poor prognosis estrogen-receptor-positive breast cancer  
The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit...
9102984 Systems and methods for individualized functional genomic profiling related to cancer cell growth  
The present invention provides systems and methods for identification of genes related to cancer cell growth. In particular, the present invention provides functional genomic profiling of primary...
9102761 Compositions for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
9102760 Compositions for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
9102706 Newly identified colon cancer marker and diagnostic kit using the same  
Provided are a newly identified colon cancer marker and a diagnostic kit using the same. More particularly, the present invention relates to an identified colon cancer specific marker, a...
9102661 Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs  
Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of...
9101631 Combination therapy based on SRC and aurora kinase inhibition for the treatment of cancer  
Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
9101630 Use of PDGF-R inhibitors for the treatment of lymph node metastasis of gastric cancer  
The present invention relates to the use of PDGF-R inhibitors for the treatment of lymph node metastasis of gastric cancers and to a method of treating mammals including humans suffering from...
9101603 Targeting of CYP1B1 in the treatment of head and neck cancer and lung cancer  
Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the...
9101585 Immunotherapy against several tumors including gastrointestinal and gastric cancer  
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present...
9101584 Methods for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
9101579 Inhibition of drug resistant cancer cells  
Provided herein are methods of treating cancer in a cancer patient by overcoming resistance of a cancer cell to a drug, or methods of overcoming resistance of a cancer cell to a drug, comprising...
9101567 Suppression of cancer growth and metastasis using nordihydroguaiaretic acid derivatives with 7-hydroxystaurosporine  
Disclosed is a composition comprising a derivative of NDGA and 7-hydroxystaurosporine. The composition can be in a unit dose form or kit. Also disclosed are methods for achieving cytotoxicity,...
9101558 Use of anti-cancer cell composition for treatment of head and neck cancer, which is intended to be administered to nutrient artery of tumor  
To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor...
9101262 Multi-modality breast cancer test system  
A method of detecting the position of potential cancer in a breast of a patient using a contour recorder (108) and a plurality of diagnostic tests (60, 62, 64) and a computer (46) having a...
9097715 Bladder cancer diagnosis and/or prognosis method  
A high sensitive and specific non-invasive bladder cancer diagnosis and/or prognosis method based on the detection and quantification of the gene expression of a combination of bladder tumor...
9096907 Prostate cancer prognostic compositions and kits  
Described herein are method, compositions and kits for prognosis of prostate cancer. The methods include determining the ratio of PCA3 and of a prostate-specific marker expression in a urine...
9096905 Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans  
The present invention provides a method of detecting DNA methylation of a plurality of genes consisting of CDKN2A, BCL2 and NID2 in a urine sample from a human. Methods and compositions are...
9096904 Method for determining lymph node metastasis in cancer or risk thereof and rapid determination kit for the same  
The objective of the present invention is to provide a method and a means of rapidly and reliably detecting lymph node metastasis in cancer or the risk of lymph node metastasis. Specifically, the...
9096901 Methods and materials related to hair pigmentation and cancer  
This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and...
9096833 Methods of treating pre-malignant ductal cancer with autophagy inhibitors  
Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug...
9096505 Anti-cancer compositions and methods  
Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the...
9095705 Scanning systems for particle cancer therapy  
A particle beam to treat malignant tissue is delivered to a patient by a gantry. The gantry includes a plurality of small magnets sequentially arranged along a beam tube to transfer the particle...
9095628 Pro-drug form (P2PDOX) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer  
Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable...
9095602 Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides  
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC)...
9095601 Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer  
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting...
9095592 Bruton's tyrosine kinase as anti-cancer drug target  
Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over half...
9095549 Diagnosis and prognosis of colorectal cancer  
The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration...
9095538 Cancer vaccines and vaccination methods  
Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
9095537 Therapy of cancer based on targeting adaptive, innate and/or regulatory component of the immune response  
The invention relates to a kit of parts, suitable for use in a therapy of cancer, wherein said kit comprises: (i) a recombinant protein comprising one or several polypeptides bearing one or...
9095270 Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof  
The present invention provides methods and apparatuses for detecting, measuring, or locating cells or substances present in even very low concentrations in vivo in subjects, using targeted...
9095040 Charged particle beam acceleration and extraction method and apparatus used in conjunction with a charged particle cancer therapy system  
The invention comprises a charged particle beam acceleration and optional extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors....
9091690 Methods of renal cancer detection  
Disclosed are methods for detecting, diagnosing or monitoring a renal cancer in a subject. The methods include detecting quantity of one or more polypeptides or fragments thereof comprised by body...