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8906606 Method of predicting and reducing risk of metastasis of breast cancer to lung  
A signature for breast cancer tissue derived from a patient is established that is indicative of the virulence and risk of lung metastasis by determining the expression levels to define a sample...
8906422 Method for inhibiting cancer using arsenic trioxide  
The invention provides a method for treating cancers that are dependent on cyclin D1 for proliferation, survival, metastasis and differentiation, involving administering a composition containing...
8906376 Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease  
Drug-Linker-Ligand Conjugates are disclosed in which a Drug is linked to a Ligand via a peptide-based Linker unit. In one embodiment, the Ligand is an Antibody. Drug-Linker compounds and Drug...
8906342 Compositions against cancer antigen LIV-1 and uses thereof  
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
8901509 Multi-axis charged particle cancer therapy method and apparatus  
The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position,...
8901306 Methods and compositions useful in treating cancer and reducing Wnt mediated effects in a cell  
Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.
8901175 Use of opioids or opioid mimetics for the treatment of resistant cancer patients  
The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients.
8901171 Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent  
The present invention provides a medicament that suppresses (or mitigates) various neurological symptoms caused by a peripheral nerve disorder induced by an anti-cancer agent.
8901137 Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors  
The invention provides compounds of Formula I: that inhibit the PI3Ks and mTOR that are useful in the treatment of cancer in humans when used in combination with autophagy inhibitors.
8901096 Method for identifying compounds for cancer therapy  
The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder...
8901093 Custom vectors for treating and preventing pancreatic cancer  
The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant...
8901082 Immunity-inducing agent and method for detection of cancer  
An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing...
8901075 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
8900819 ADRB2 cancer markers  
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to...
8900813 CIP2A as a biomarker in detection of cervical cancer  
The present invention provides methods and compositions for detecting cervical cancer in a human. The present invention provides CIP2A as a biomarker detectable in a biological sample from cervix...
8900588 Methods for treating breast cancer  
The present disclosure is directed to methods of treating and preventing breast cancer or recurrence of breast cancer with compositions comprising anti-progastrin antibodies.
8896239 Charged particle beam injection method and apparatus used in conjunction with a charged particle cancer therapy system  
The invention comprises a charged particle beam injection method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam...
8895746 Compounds that suppress cancer cells and exhibit antitumor activity  
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs,...
8895719 Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein  
A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the...
8895611 Cytotoxic compounds for treating cancer  
The cytotoxic compounds are gold(III) complexes of the type [(diaminocyclohexane)AuCl2]Cl, derived from sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O. Specifically, the cytotoxic compounds...
8895605 Pyrrolidine-substituted flavones as radio-sensitizers for use in the treatment of cancer  
The present invention relates to a combination for the treatment of cancer wherein the combination exhibits a synergistic effect. The combination comprises radiation and at least one cyclin...
8895556 Compounds and method for treatment of cancer  
The invention relates to a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein the...
8895523 Use of antisense oligonucleotides against CPLA2 in the treatment of cancer  
Inhibitors of cPLA2α expression are used in the preparation of pharmaceutical compositions for the inhibition of cancer cell proliferation and for the treatment of cancer; the inhibitors are...
8895514 Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers  
The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper...
8895509 MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells  
The present invention provides a method of treating an ovarian cancer, the method comprising delivering one or more miR-200 family members to a mammalian subject in need thereof in an amount...
8895031 Reagents and methods for cancer treatment and prevention  
The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or...
8895013 Anthracycline-antibody conjugates for cancer therapy  
The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline...
8889737 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer  
The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or...
8889713 N-substituted tetrahydroisoquinoline benzamides/benzene sulfonamides as anti-cancer agents  
The compounds herein disclosed are N-substituted tetrahydroisoquinoline benzamide and benzene sulfonamide compounds that have modifications on the phenyl rings by introducing groups with various...
8889689 Bifunctional metnase/intnase inhibitors and related compositions and methods of treatment of cancer  
This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical bifunctional inhibitors of DNA...
8889675 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed...
8889642 Methods and compositions for RNAi-based cancer treatment  
The present invention generally concerns methods and compositions for treating mutated K-ras expressing cancers.
8889365 Methods and kit for detecting breast cancer  
The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary...
8889354 Methods for the identification, assessment, and treatment of patients with cancer therapy  
The present invention is directed to the identification of predictive markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a...
8889192 Magnetic nanomedicine for inhibiting/treating human prostate cancer  
The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a...
8889143 Ii-key/HER-2/neu hybrid cancer vaccine  
Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class...
8884006 Small-molecule inhibitors of Rac1 in metastatic breast cancer  
A novel inhibitor of Rac activity based on the structure of the established Rac/Rac-GEF inhibitor NSC23766 is discloses. The compound EHop-016, with an IC50 of 1.1 μM, is a 100-fold more efficient...
8883832 Compounds, compositions, and methods for preventing metastasis of cancer cells  
Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.
8883784 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed...
8883760 Cancer therapy using beta glucan and antibodies  
The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal...
8883757 Compositions and methods for treatment of ovarian cancer  
The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to...
8883737 Methods of treating cancer  
Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include...
8883736 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
8883718 Treating cancer  
Provided is a cyclic peptide which comprises: (i) a CDK4 peptide region; and(ii) a cell-penetrating region; wherein the CDK4 peptide region comprises the amino acid sequence P1R1x1y1R2P2V (SEQ ID...
8883497 Human myeloid derived suppressor cell cancer markers  
Provided herein are methods for determining the presence of cancer (malignant versus benign), monitoring the progression of cancer, monitoring cancer relapse, monitoring the response to cancer...
8883218 Anti-cancer nanoparticle compositions and methods of use  
The present invention encompasses a composition capable of delivering and expressing a nucleic acid encoding UDP-Glucuronosyltransferases, p53 or a combination thereof into a cell, and methods for...
8883159 Antibodies against CDCP1 for the treatment of cancer  
The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
8883149 Antibody combinations and use of same for treating cancer  
A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and...
8877803 Stat3 pathway inhibitors and cancer stem cell inhibitors  
The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods...
8877765 Highly soluble pyrimido-dione-quinoline compounds and their use in the treatment of cancer  
The present invention features pyrimido-dione-quinoline compounds having improved solubility, pharmaceutical compositions of substituted pyrimido-dione-quinoline compounds and methods of treating...