Sign up


Match Document Document Title
8445638 Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells  
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a...
8445537 Compounds that inhibit human DNA ligases and methods of treating cancer  
Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA...
8445507 Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases  
A hydantoin compound useful for the prevention or treatment of hyperproliferative diseases or disorders.
8445492 Method for inhibiting growth of cancer cells and cell telomere and diseases of cell proliferation by using heteroannelated anthraquinone derivative compounds  
A heteroannelated anthraquinone derivative compound is provided. The heteroannelated anthraquinone derivative compound is represented by a formula (I): wherein R1 is a substituent being one...
8445442 CCL18 and CCL3 methods and compositions for detecting and treating cancer  
The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating...
8445268 Her-2/neu DNA vaccine having anti-cancer activity  
The present invention relates to human Her-2/neu expressing plasmid constructs having anti-cancer activity and a DNA vaccine comprising same for preventing and/or treating cancer. The Her-2/neu DNA...
8445211 I-Plastin assay method for the in vitro diagnosis of colorectal cancer  
A method for the in vitro diagnosis of colorectal cancer by determining the presence of the I-Plastin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer....
8445202 Method of detecting colon cancer marker  
It is intended to provide a non-invasive and convenient method of detecting a tumor marker for diagnosing colon cancer which is superior in sensitivity and specificity to the existing fecal occult...
8444988 Cancer treatment method  
A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the...
8444983 Composition of anti-ENDO180 antibodies and methods of use for the treatment of cancer and fibrotic diseases  
The present invention provides antibodies or antigen-binding fragments thereof that specifically bind the ENDO180 polypeptide and are internalized thereby, to conjugates comprising the molecules,...
8444974 Use of antibodies for the vaccination against cancer  
Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
8444965 Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines  
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified...
8442629 Iontophoresis preparation for treating breast cancer and/or mastitis  
Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis. An iontophoretic preparation for treatment of breast cancer and/or mastitis...
8440798 Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies  
The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the invention are a pharmaceutical...
8440714 Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents  
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of...
8440410 Reagents and methods for use in cancer diagnosis, classification and therapy  
Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for...
8440409 Protein C inhibitor as a biomarker for prostate cancer  
The present invention provides a protein-based biomarker, Protein C Inhibitor (PCI) that is useful in qualifying prostate cancer status in a patient. In particular, the biomarker of this invention...
8440407 Gene expression profiles to predict relapse of prostate cancer  
The present disclosure provides a method for cancer relapse prediction that provides higher resolution grading than Gleason score alone. In particular, the method provides for prediction of...
8440402 Gene detection assay for improving the likelihood of an effective response to a HER2 antibody cancer therapy  
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing HER2, as determined by a gene amplification assay, with a HER2...
8440396 Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer  
This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or...
8440184 Compositions of engineered human arginases and methods for treating cancer  
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate...
8440180 Anti-cancer composition comprising aquatic microbial extract  
There is provided an anti-cancer composition comprising an aquatic microbial extract, and there is more particularly provided an anti-cancer composition comprising a Bacillus sp. strain extract.
8436327 Multi-field charged particle cancer therapy method and apparatus  
The invention relates to treatment of solid cancers. More particularly, the invention relates to a combined rotation/raster method, referred to as multi-field charged particle cancer therapy. The...
8436145 Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases related to Beclin-1  
The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing...
8435993 Methods of inhibiting metastasis from cancer  
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or...
8435959 Effective treatment of tumors and cancer with triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination of (i) administering triciribine only...
8435748 Method for monitoring, diagnosing, and screening cancer through measuring the concentration of des-R prothrombin activation peptide fragment F2 (des-R F2) in a serum  
The present invention relates to a method for diagnosis and screening of cancer by measuring the expression of des-R prothrombin activation peptide fragment F2 (des-R F2) in serum, more precisely,...
8435746 Aldehyde dehydrogenase 1 (ALDH1) as a cancer stem cell marker  
The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides a novel stem cell cancer marker, ALDH1,...
8435734 Cancer marker and use thereof  
This invention provides a method for cancer diagnosis comprising measuring an endogenous antisense RNA whose relative expression to a sense RNA changes cancer-specifically in RNA-containing samples...
8435575 Use of gingerols for cancer patients suffering from nausea and emesis induced by chemotherapy  
This invention is for an improved method for making enhanced ginger capsules and for using these capsules for treating nausea and emesis in cancer patients.
8435534 Cancer immunotherapy  
A method for stimulating a immune response against IL-13Rα2 in a subject having or at risk for developing a disease having cells expressing IL-13Rα2 includes the steps of formulating the a...
8435531 Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response  
The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation...
8435529 Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy  
Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than...
8435516 Cancer treatment  
The present invention relates to methods of treating cancer, such as melanoma, by administering a CTLA4 antagonist to a subject with a serum C-Reactive Protein (CRP) concentration that is less than...
8435507 Prostate-specific antigen-derived MHC class II restricted peptides and their use in vaccines to treat or prevent prostate cancer  
The present invention relates to immunogenic peptides derived from human prostate cancer antigen (PSA-derived peptides) and their use as vaccines to treat or prevent prostate cancer. The invention...
8435489 Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma  
The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present...
8431708 Fluorescent carbazole compounds for cancer diagnosis  
A compound of formula (I): in which R1-R8, A, B, X, Y, m, and n are as defined herein. Also disclosed is a method for detecting a cancer cell using a compound of formula I.
8431695 Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases  
This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them,...
8431587 Method for the treatment of cancer  
The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and...
8431550 Topical anti-cancer compositions and methods of use thereof  
Described are skin-care compositions containing non denatured soy products and optionally other anti-cancer or anti-aging agents. The compositions can be applied topically to reduce the risk of...
8431546 Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy  
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods...
8431536 Target for breast cancer therapy and/or diagnosis  
The present invention relates to breast cancer and methods for identifying therapeutics and diagnosis. In general, methods for identifying therapeutic agents directed to calcium flow arc disclosed....
8431530 Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also...
8431165 Medicament for treatment of cancer and other diseases  
A medicament for the treatment of cancer and other diseases, including cardiovascular diseases, by increasing cellular oxygenation is described wherein a composition of organically grown,...
8426571 Nucleic acids and corresponding proteins entitled 202P5A5 useful in treatment and detection of cancer  
A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
8426561 Antibodies against a cancer-associated epitope of variant NFKBIB and uses thereof  
The present application provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of a cancer specific antibody directed to an epitope of...
8426422 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
8426398 Conjugates of noscapine and folic acid and their use in treating cancer  
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs),...
8426394 Progesterone antagonists such as CDB-4124 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer, etc  
The present invention relates to methods of administering compositions comprising a progesterone receptor antagonist for use in treating estrogen-dependent conditions. The invention is also...
8426390 Triazene compounds for the treatment of cancer  
The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer...