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8728739 RBM3 in colorectal cancer prognostics  
The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of...
8728732 Global DNA hypomethylation and biomarkers for clinical indications in cancer  
The present invention provides methods of determination of a global DNA methylation index (GDMI) in a sample from a subject, using a variety of methods which can detect global, genome-wide, and...
8728546 Medicament for treatment of cancer, cardiovascular diseases and inflammation  
The invention provides a medicament for the treatment of cancer, cardiovascular diseases and/or inflammation. The medicament may be administered orally, parenterally or topically.
8728468 Treatments for cancer  
The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing melanoma tumor survival, expansion, and...
8725426 Gene expression profile algorithm and test for determining prognosis of prostate cancer  
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes, or their co-expressed genes, from a biological sample obtained from a...
8722964 Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes  
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In...
8722897 Metal complexes of thiourea and derivatives as metal delivering anti-cancer and anti-inflammatory agents  
The present invention relates to metal thiourea complexes comprising N-substituted thiourea ligands and sulfur-coordinated metal ions, and methods for using the metal thiourea complexes for...
8722367 Detecting PAX2 for the diagnosis of breast cancer  
A method for monitoring breast conditions in a subject is disclosed. The method comprises determining a Paired Box 2 gene-to-beta defensin-1 gene (PAX2-to-DEFB1) expression ratio (the “Donald...
8722340 JAB1 as a prognostic marker and a therapeutic target for human cancer  
Methods of diagnosing and prognosticating the development of human cancers, such as breast cancer, colon cancer, and pancreatic cancer, are provided. The diagnostic and prognostic methods include...
8722331 Method for selecting a treatment for non-small cell lung cancer using gene expression profiles  
The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased...
8722325 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
8722088 Pharmaceutical compositions and methods for the treatment of prostate cancer  
Compositions, kits, and methods are provided directed to the treatment of prostate cancer using a maintenance dose of degarelix or pharmaceutically acceptable salt thereof, an excipient, and a...
8722050 Method of treating virus-induced cancer  
The present invention relates to methods of treating virus-induced cancer with the polypeptides that are capable of killing cells. The polypeptide comprises a targeting agent covalently attached...
8718996 Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents  
A testing method for identification whether a cancer patient is a member of a group or class of cancer patients that are not likely to benefit from administration of a platinum-based chemotherapy...
8718231 X-ray tomography method and apparatus used in conjunction with a charged particle cancer therapy system  
The invention comprises an X-ray tomography method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. In various embodiments,...
8716355 Hydroxylated tolans and related compounds in the treatment of a cancer  
Compounds of the hydroxytolan family kill tumor cells, inhibit tumor growth and development, and are thus useful in method for treating a tumor or cancer in subjects in need thereof. These...
8716346 Alkylating agent combinations in the treatment of cancer  
This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic...
8716328 Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents  
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of...
8716299 XIAP-targeted prostate cancer therapy  
A treatment for prostate cancer using cyclin-dependent kinase inhibitors is provided. The effects of cyclin-dependent kinase inhibitors on the survival of prostate cancer cells was examined....
8716297 Chemical entities to be used for Wee1 inhibition for the treatment of cancer  
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, A, B, and n are defined in the description. The present invention relates also to...
8716285 N-hydroxy-benzamids for the treatment of cancer  
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The...
8716257 CMV gene products promote cancer stem cell growth  
The disclosure relates generally to compositions and methods useful for inhibiting the infection and propagation of viral particles, particularly members of the Herpesviridae family, and more...
8716234 Cytotoxins comprising modified bouganin toxin for the treatment of cancer  
The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The...
8716224 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
8716014 Adenovirus E1A fragments for use in anti-cancer therapies  
The present invention relates to an improved cancer therapy comprising co-administration with the E1A 1-80 transcription-repression domain activity. In addition, E1A 1-80 can act as a monotherapy...
8715945 Methods of cancer diagnosis and therapy targeted against a cancer stem line  
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
8715931 Method for analyzing cervical lymph node metastasis, and tumor marker for head and neck cancer  
Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for...
8715928 Molecular-based method of cancer diagnosis and prognosis  
A gene profiling signature for diagnosis and prognosis of cancer patients is disclosed herein. In one embodiment, the gene signature includes 32 or 79 cancer survival factor-associated genes....
8715748 Methods for inhibiting prostate cancer by kinases and angiogenesis inhibitory mechanisms of ball moss extract  
A method of treating prostate cancer by administering a pharmaceutically-acceptable amount of a crude extract of the indigenous Jamaican plant Ball Moss (Tillandsia Recurvata) comprising one or...
8715670 Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same  
The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the...
8715667 Methods of treating patients having TLR3-positive cancer  
The present invention relates to antibodies, antibody fragments, and derivatives thereof that specifically bind to TLR3 cell receptors present on the surface of cells. The invention also relates...
8715665 Methods for treating cancer resistant to ErbB therapeutics  
Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene...
8712142 Method and apparatus for analysis of histopathology images and its application to cancer diagnosis and grading  
The invention relates to histology analyses, and in particular, to the assessment of pathological tissues to aid in the diagnosis of disease characterized by specific pathologies, for example...
8710462 Charged particle cancer therapy beam path control method and apparatus  
The invention comprises a charged particle beam path coupling an injector, synchrotron accelerator, beam transport system, targeting system, and/or patient interface method and apparatus....
8710104 Catecholic butanes and use thereof for cancer therapy  
The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic...
8710099 Treatment of cancer using the sodium salt of a benzoic acid derivative  
The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.
8710091 Imidazolidine-2,4-dione derivatives, and use thereof as a cancer drug  
The present application relates to novel imidazolidine-2,4-dione derivatives of the general formula (I), where R1, R2, R3, R4, X, and Y are variables. Said materials have an antiproliferative...
8710068 Method of treating cancer using a survivin inhibitor  
Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a...
8710035 Methods and compositions related to glucocorticoid receptor antagonists and breast cancer  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other...
8710020 Clusterin antisense therapy for treatment of cancer  
A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefits in the treatment of cancer comprising administering from 40 to 640 mg...
8709981 Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development  
The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are...
8709732 Biomarkers of gastric cancer and use thereof  
A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression...
8709731 DKK1 oncogene as therapeutic target for cancer and a diagnosing marker  
Described herein are antibodies and antibody fragments capable of treating or preventing cancers associated with the over-expression and/or up-regulation of DKK1. Also disclosed are methods of...
8709719 ZNF217 a new prognostic and predictive biomarker of recurrent invasive and metastatic phenotypes in breast cancer  
The present invention relates to methods for determining the prognosis of a cancer. The methods involve determining the level of expression of the ZNF217 gene in a cancer cell sample or in a tumor...
8709718 Method of treating lung cancer  
A method of predicting a lung cancer patient's response to FGFR inhibitors is disclosed herein, particularly in patients with squamous cell lung cancer.
8709474 Liposomes with improved drug retention for treatment of cancer  
The present invention relates to the use of copper ions to achieve enhanced retention of a therapeutic agent within a liposome. The invention may be employed to more effectively deliver a...
8709432 Methods for increasing efficacy of FOLR1 cancer therapy  
Methods to improve the success of cancer therapies that target the human folate receptor 1 are provided. Kits comprising reagent useful in the methods are further provided.
8709430 Cancer treatment kits comprising therapeutic antibody conjugates that bind to aminophospholipids  
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
8709418 Pharmaceutical composition for treating CAPRIN-1 expressing cancer  
According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen...
8709417 Combination immunotherapy for the treatment of cancer  
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.