Match Document Document Title
9827325 Drug delivery of temozolomide for systemic based treatment of cancer  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
9827309 Treating cancer with a combination of a PD-1 antagonist and dinaciclib  
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and the CDK inhibitor dincaciclib, and the use of the combination therapies...
9827288 Method for treating a refractory or relapsed lung cancer  
The present invention relates to a method for treating a refractory or relapsed lung cancer. Particularly, the invention provides a method and a formulation of using an immunomodulatory protein...
9827261 Etoposide and prodrugs thereof for use in targeting cancer stem cells  
The present invention pertains to the use of podophyllotox in derivatives, such as CAP7.1, in methods for inhibition of and/or prevention of the growth and/or survival of cancer stem cells. The...
9827224 Methods and compositions for ameliorating pancreatic cancer  
Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the...
9822417 Methods and biomarkers for analysis of colorectal cancer  
The present invention relates to methods and biomarkers (e.g., gene expression biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool...
9822416 miRNA in the diagnosis of ovarian cancer  
The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g....
9822363 Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer  
The present disclosure relates generally to cancer and particularly to breast cancer including estrogen sensitive, estrogen resistant and triple negative breast cancer (TNBC), and to methods of...
9822202 Polymer/copper combination for targeted cancer therapy  
Polymer/copper combination that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol...
9822174 Anti-VEGF antibody, and pharmaceutical composition for preventing, diagnosing or treating cancer or angiogenesis-related diseases, containing same  
A novel anti-vascular endothelial growth factor (VEGF) antibody having a strong binding affinity for VEGF and capable of inhibiting in vivo tumor growth and a composition for the treatment of...
9822170 Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer  
Epidermal growth factor receptor (EGFR) expression and phosphorylation is increased in cancer cells treated with anti-clusterin antibodies. Such treatment is also accompanied with the reappearance...
9822139 Pharmaceutical composition containing cyclometalated N-heterocyclic carbene complexes for cancer treatment  
The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene...
9822111 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer  
The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Q, R1, R2, R3, R4 and R5 have any of the meanings defined herein. The...
9822064 Methods of producing cancer treating compounds  
Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
9821173 Anti-cancer agents and methods of use  
An anti-cancer agent includes Au(I) purinyl, indolyl, or azaindolyl analogues encapsulated in sterically hindered phosphine ligands.
9821061 Enhanced plasmonic nanoparticles for cancer therapy and diagnostics  
One or more techniques and/or products are disclosed using a process for preparing metallic nanoparticles. Resulting nanoparticles may comprise a gold-silver-gold core-shell-shell nanoparticles....
9820992 Method of treating non-small-cell lung cancer using pharmaceutical formulation containing thienotriazolodiazepine compounds  
A method of treating non-small cell lung cancer in a mammal by administering to a patient a pharmaceutically acceptable amount of a compound being a thienotriazolodiazepine compound of the Formula...
9820963 Composition containing lignan compound as active ingredient for preventing or treating cancer  
The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for...
9820949 Methods of treatment of pancreatic cancer  
The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer (e.g., gemcitabine-based therapy) by...
9816996 Antibody for detecting epithelial ovarian cancer marker and method for diagnosing epithelial ovarian cancer  
The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the...
9816995 Biomarker for ovarian cancer CTAP3-related proteins  
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a...
9816139 Mean DNA copy number of chromosomal regions is of prognostic significance in cancer  
Methods for predicting a disease free time interval (DFI) for a cancer patient under consideration for initial or further chemotherapy treatment are disclosed. The methods include obtaining a...
9816083 Genetically engineered bacterium for treatment of breast cancer, method for constructing the bacterium, and applications thereof  
The current invention discloses a genetically engineered bacterium used for the treatment of breast cancer. The said bacterium is attenuated Salmonella typhimurium VNP20009 with cloned...
9815906 Method of inhibiting or treating cancer metastasis  
The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence, status or metastasis of cancer by detecting plasma Hsp90α having...
9815901 Treatment of cancer using a CD123 chimeric antigen receptor  
The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors...
9815845 Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics  
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a...
9814767 Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide  
This document provides methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for...
9814759 Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment  
The present invention provides a pharmaceutical composition containing recombinant hemoglobin protein or tetramer or dimer or subunit for tissue oxygenation and treating cancer. The recombinant...
9814707 Cancer stem cell proliferation inhibitor and intracellular active oxygen accumulation inducer  
The present invention is directed to provide cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species. To this end, provided are cancer stem...
9814703 Methods for treating cancer by activation of BMP signaling  
Methods for treating cancer by activation of the Bmp pathway are disclosed. In particular, the invention relates to methods of treating cancer using agents that activate BMP signaling, e.g., FK506...
9814694 Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders  
Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective...
9814449 Motorized optical imaging of prostate cancer  
A system, method, and storage device storing computer executable instructions for use in tissue analysis and therapy. A motorized optical probe for illuminating tissue generates light fluorescence...
9814448 Three-dimensional optical imaging and therapy of prostate cancer  
A system, method, and storage device storing computer executable instructions for use in tissue analysis and therapy. An optical probe array has at least two or more optical probes for...
9810691 Biomarker for detecting cancer  
Methods for detecting colorectal cancer in a subject by detection of a galactose-containing 40 kDa molecule in a serum sample from the subject. Methods for quantifying the amount of a...
9809859 Biomarkers for subtypes of cervical cancer  
The present invention relates to biomarkers for chemoradioresistant subtypes of cervical cancer. In particular the present invention relates to a method for predicting a predisposition to a...
9809858 O-glycan pathway ovarian cancer signature  
Biomarkers, methods, assays, and kits are provided for determining the prognosis of and treating a patient with ovarian cancer. Also disclosed are biomarkers, methods, assays, and kits for...
9809857 Methods and signatures for oropharyngeal cancer prognosis  
Methods for determining the prognosis of a subject with oropharyngeal squamous cell carcinoma are described, as well as miRNAs and panels of prognostic miRNAs that are used in the methods.
9809815 Methods and compositions for diagnosis and treatment of cancer  
The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which...
9809810 Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells  
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of...
9809651 Method of treating cancer with an EGFR targeted immunomodulatory fusion protein  
The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins,...
9809631 Targeting of podoplanin with lectin for use in the prevention and treatment of cancer  
Lectin compositions and methods for reducing tumor cell growth and preventing or treating cancer are provided.
9809616 Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer  
The compounds are of the class of N4-hydroxycytidine nucleosides, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives...
9809615 Anti-cancer compounds from invasive salvinias and methods of treating cancer  
Compositions and methods related to anti-cancer terpenoid compounds isolated from plants in the Salviniaceae family, pharmaceutical compositions comprising the same, and methods of treating cancer.
9809562 NAT10 modulators for treating or preventing laminopathies, aging and cancer  
The invention relates to compounds in the treatment or prevention of disorders associated with Lamin A and/or Lamin C depletion or LMNA mutations, such as laminopathy, premature ageing disorders,...
9809549 Malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer  
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fl uorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate...
9808543 Iron garnet nanoparticles for cancer radiotherapy and chemotherapy  
Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron...
9808526 Pharmaceutical kit and methods for cancer treatment via intracavity delivery and for preparing metal nanoparticle-antibody fragment conjugate  
The present invention provides a pharmaceutical kit, methods for cancer treatment and for preparing a metal nanoparticle-antibody fragment conjugate, which can reduce the recurrence rate of cancer...
9808524 Combination of local and systemic immunomodulative therapies for melanoma and liver cancer  
A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition,...
9808516 Immunogenic fusion proteins for the treatment of cancer  
Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of...
9808513 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as...