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7820683 |
4-(1H-indazol-5-yl-amino)-quinazoline compounds as erbB receptor tyrosine kinase inhibitors for the treatment of cancer
A quinazoline derivative of the Formula I: wherein the substituents are as defined in the text for use in the production of an anti-proliferative effect which effect is produced alone or in part by...
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7820665 |
Imidazopyridazine inhibitors of PI3 kinase for cancer treatment
The present invention relates to imidazopyridazine compounds of Formula I, such as representative structure A, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase;...
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7820635 |
RNAi probes targeting cancer-related proteins
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder...
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7820447 |
Compositions and methods for cancer
The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially lymphoma carcinomas. In addition, the present invention describes the use of novel...
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7820401 |
Collagen VI and cancer
Methods of determining whether a cancer is progressing by measuring surface-bound collagen VIα3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring ...
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7820386 |
Cancer screening method
A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation state of the CpG sequence in at least one target gene within the genomic...
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7820382 |
Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation
A method for the early diagnosis of breast, lung, pancreatic and colon growths and cancers as well as conditions associated with donor and recipient organ transplants, both before and after...
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7820200 |
Pharmaceutical composition for the sustained release of hydralazine and use thereof as a support for cancer treatment
The invention relates to a substained release form of hydralazine for use in cancer therapy. The substained release form of hydralazine can be used to obtain a constant concentration of the active...
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7820155 |
Methods of treating cancer comprising administering an interleukin-6 antibody variable region
The present invention provides an isolated IL-6 antagonist including an antibody variable region that prevents IL-6 from binding to gp130. The present invention also provides compositions and...
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7816403 |
Method of inhibiting ATF/CREB and cancer cell growth and pharmaceutical compositions for same
There is provided a method for inhibiting ATF/CREB and cancer cell growth using disulfiram, administered in combination with heavy metals. It was found that disulfiram disrupts transcription factor...
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7816323 |
Methods of using corticotropin-releasing factor for the use of the treatment of cancer
Provided herein is a method for treating cancer in a human by administering a high dose of corticotropin-releasing factor (CRF).
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7816131 |
Cancer specific promoters
The present invention regards cancer-specific control sequences that direct expression of a polynucleotide encoding a therapeutic gene product for treatment of the cancer. Specifically, the...
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7816088 |
Identification, isolation and elimination of cancer stem cells
Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery...
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7816087 |
Gene expressed in prostate cancer and methods of use
A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are...
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7816082 |
Methods of identifying pancreatic cancer cells
Methods that identify cells as pancreatic cancer cells based on assessing the expression of combinations of target molecules expressed preferentially on pancreatic cancer cells are disclosed....
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7816077 |
Method of detecting colon cancer marker
It is intended to provide a non-invasive and convenient method of detecting a tumor marker for diagnosing colon cancer which is superior in sensitivity and specificity to the existing fecal occult...
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7816076 |
Therapeutic targets in cancer
The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide...
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7815902 |
Methods and compositions for cancer therapy using a novel adenovirus
The invention comprises a novel virus that can kill mammalian cancer cells efficiently. The virus produces a novel protein that converts two non-toxic prodrugs into potent chemotherapeutic agents....
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7812143 |
Biomarkers for cancer treatment
The present invention provides identification of a thirty-five gene set that predicts the anticancer activity of inhibitors of the RAF/MEK/MAPK pathway, methods of qualifying cancer status in a...
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7812128 |
Gene overexpressed in cancer
Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding...
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7812058 |
Methods and compounds useful to induce apoptosis in cancer cells
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
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7812002 |
Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer
The invention provides novel double stranded oligoribonucleotides that inhibit the Nrf2 gene. The invention also provides a pharmaceutical composition comprising one or more such...
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7811982 |
Compounds and methods for treating cancer
The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also...
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7811778 |
Methods of screening for gastrointestinal cancer
Methods for diagnosing an upper gastrointestinal (GI) cancer in a subject by determining an amount of one or more biomarkers in a biological sample from the subject are provided. Methods for...
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7811774 |
Reagents and methods for use in cancer diagnosis, classification and therapy
Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for...
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7811772 |
Apolipoprotein A-II isoform as a biomarker for prostate cancer
The present invention provides a protein-based biomarker, ApoA-II isoform, that is useful in determining prostate cancer status in a patient. In particular, the biomarker of this invention is...
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7811752 |
Plasma or serum marker and process for detection of cancer
This disclosures provides, in one aspect, a method for detecting non-clinically diagnosed cancer in a patient. In one embodiment, the method includes extracting blood serum or plasma from the...
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7811575 |
Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer
A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
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7811564 |
Prostate cancer diagnosis and treatment
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof. The present invention also...
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7807710 |
Macrocycles for the treatment of cancer
The invention relates to the novel macrocycles of general formula (I) and to their use in the treatment of tumor diseases.
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7807647 |
Methods and compositions for cancer therapy
The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition...
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7807630 |
Targeting of Notch3 receptor function for cancer therapy
The present invention involves the use of peptides from Notch3, and antibodies that recognize epitopes represented by those peptides, as anti-cancer agents. Methods of combination therapy using...
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7807393 |
Biomarkers for prostate cancer
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the prostate. In particular, the present invention provides compositions and...
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7807379 |
Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker
The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples...
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7807373 |
Prostate specific gene, PCGEM1, and methods of using PCEGM1 to detect, treat, and prevent prostate cancer
A nucleic acid sequence that exhibits prostate-specific expression and over-expression in tumor cells is disclosed. The sequence and fragments thereof are useful for detecting, diagnosing,...
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7807186 |
Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified...
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7807183 |
Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished...
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7807146 |
Methods for treating cancer with a recombinant MVA expressing HER-2
The invention relates to compositions, kits, and methods for cancer therapy using recombinant MVA viruses encoding a tumor-associated antigen, such as HER-2, particularly in combination with...
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7807136 |
Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
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7805183 |
Stromal collagen in the diagnosis and characterization of breast cancer
The present invention provides methods and systems for evaluating biological materials for the diagnosis of disease, such as gland abnormalities, and the cancerous and precancerous conditions....
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7803917 |
Breast cancer resistance protein (BCRP) and antibodies thereto
The present invention provides a breast cancer resistance polynucleotide and protein of Macaca mulata (rhesus monkey) and uses thereof. The present invention also provides anti-BCRP antibodies and...
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7803916 |
Gene expressed in prostate cancer
A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety...
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7803831 |
3-(2-hydroxy-phenyl)-1H-pyrazole-4-carboxylic acid amide derivatives as HSP90 inhibitors for the treatment of cancer
Compounds of formula (IA) or (IB) or salts, N-oxides, hydrates or solvates thereof are Inhibitors of HSP90, and useful in the treatment of, for example, cancer: formula (IA), formula (IB) wherein...
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7803552 |
Biomarkers for predicting prostate cancer progression
The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose...
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7799811 |
Agent for prevention and treatment of cancer comprising oxadiazole urea compound obstructing activity of stat
Disclosed herein is an agent for preventing and treating cancer which includes an oxadiazole urea compound represented by Chemical Formula 1, below, as an effective ingredient. The oxadiazole urea...
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7799518 |
Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating...
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7799327 |
Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment
This invention describes a method whereby human autoimmune antibodies are used as carrier compounds to deliver imaging agents and pharmaceutical drugs to the tumor in the human patient. These...
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7795448 |
Imidazoyl-benzamide anti-cancer agents
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
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7795409 |
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof
The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this...
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7795407 |
Metastatic breast and colon cancer regulated genes
Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs....
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