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10413538 Administration of karenitecin for the treatment of platinum and/or taxane chemotherapy-resistant or -refractory advanced ovarian cancer  
The present invention discloses and claims methods and compositions for the treatment of subjects having advanced ovarian cancer, including platinum and/or taxane chemotherapy resistant or...
10413531 Methods of treating bladder cancer  
The present invention provides methods and compositions for treating bladder cancer, including metastatic bladder cancer and non-muscle-invasive bladder cancer, by administering a composition...
10412939 Rodent model of prostate cancer  
This disclosure provides a rodent model of prostate cancer. The rodents disclosed herein comprise a transgene that provides prostate-specific expression of an oncogenic protein (e.g, an SV40 tumor...
10408839 Biomarker panel for diagnosing cancer  
An in vitro method for the diagnosis, prognosis, stratification and/or monitoring of colorectal cancer in a subject includes detecting the level of AREG, CEA, HGF-receptor, ErbB4-Her4, CD69, PSA,...
10407738 Markers for breast cancer  
Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and...
10407737 Methods and kits for identifying pre-cancerous colorectal polyps and colorectal cancer  
Methods and kits for identifying a subject having pre-cancerous advanced polyps or colorectal cancer based on the expression profile(s) of specific mRNA biomarkers. Methods and kits for...
10407736 Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration  
The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be...
10407731 Biomarker panels for predicting prostate cancer outcomes  
This document provides methods and materials related to assessing male mammals (e.g., humans) with prostate cancer. For example, methods and materials for predicting (1) which patients, at the...
10407446 Amino-triazolopyridine compounds and their use in treating cancer  
The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where R1 and R2 have any of the meanings defined herein. The specification also...
10406248 Molecular imaging of cancer cells in vivo  
Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as...
10406228 Process for making iron oxide nanoparticle preparations for cancer hyperthermia  
Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (HGCP), and methods of using the nanoparticles are disclosed.
10406216 In situ antigen-generating cancer vaccine  
The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
10406188 Method for inhibiting telomerase in cancer cell using luterion  
The present disclosure relates to a method for inhibiting telomerase in cancer cells by means of luterion and, more particularly, to a method for inhibiting telomerase activity in cancer tissues,...
10406185 Cancer therapy with a parvovirus combined with a BCL-2 inhibitor  
Described is a pharmaceutical composition comprising (a) a parvovirus and (b) an Bcl-2 inhibitor and the use of said composition for treatment of cancer, e.g., a solid tumor. Preferred inhibitors...
10406138 Pharmaceutical combinations for treating cancer  
The present invention is directed to a combination comprising a proteasome inhibitor and a compound of formula I or a pharmaceutically acceptable salt thereof: to a pharmaceutical composition and...
10406128 Treatment and diagnosis of colon cancer  
The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
10406125 Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2O2 level in cancer cells of a subject  
The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl...
10406124 Method of treatment of gynecological cancer with anti-RAGE antibodies  
A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation End (RAGE) products linked to an anti-cancer drug, for use in the treatment of gynaecological...
10401365 Inhibition of chemokine CCL7 or receptor CCR3 of same for the treatment and diagnosis of prostate cancer  
The invention concerns an inhibitor of the expression of chemokine CCL7 or an inhibitor of the expression of the receptor CCR3 or an inhibitor of CCL7/CCR3 interaction for the use of same to...
10401364 Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling  
The present invention provides methods for selecting a suitable anticancer drug therapy, and for identifying and predicting response, for the treatment of colorectal cancer. The present invention...
10401357 Treating cancer  
A method for treating cancer comprising applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of...
10400290 Mitochondrial DNA deletion between about residues 12317-16254 for use in the detection of cancer  
The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples,...
10400288 MicroRNA-based method for early detection of prostate cancer in urine samples  
The present application concerns a new in vitro method for assessing the risk that a subject suffers from prostate cancer. The method comprises measuring the expression level the level of at least...
10400045 Internalizing human monoclonal antibodies targeting prostate and other cancer cells  
In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer...
10400012 Methods for treating cancer  
Peptides having a human minute binding protein-2 (HDM-2) targeting sequence are capable of targeting the human minute binding protein-2. Peptides having an HDM-2 targeting sequence may be used to...
10400011 Peptides, combination of peptides, and cell based medicaments for use in immunotherapy against urinary bladder cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10400010 Structure-based peptide inhibitors of P53 aggregation as a new approach to cancer therapeutics  
This invention relates, e.g., to an inhibitory peptide or CPP inhibitor which specifically binds to p53 having an aberrant conformation (e.g., is aggregated or misfolded) and inhibits p53...
10400008 Modulators of the SRC-kinase activity for preventing or treating metastatic cancer  
The invention provides a molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer a subject. Preferably, the molecule comprises or consists...
10399990 Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer  
This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine...
10399989 Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer  
This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine...
10399962 Azolopyrimidine for the treatment of cancer-related disorders  
Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The...
10399933 Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer  
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods...
10399932 Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer  
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods...
10398792 Method for producing radiobacteria for therapy of cancer  
A method of producing radiobacteria is provided, especially radiolisteria-32P. Compositions and methods of use thereof are also provided.
10398791 Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer  
The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of...
10398778 Method for enhancing specific immunotherapies in cancer treatment  
Methods and compositions of the invention relate to the enhancement of specific immunotherapies in cancer treatment. In particular, aspects of the invention relate to novel approaches to boost...
10398696 Combinations for treatment of cancer  
The current disclosure relates to pharmaceutical combinations and compositions useful in the treatment of certain types of cancer. The disclosure also relates to method of treatment these certain...
10398685 Methods of treating pancreatic cancer  
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients...
10398678 Indomethacin analogs for the treatment of castrate-resistant prostate cancer  
Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin...
10398672 Methods and compositions for targeting cancer stem cells  
Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a mesenchymal to epithelial transition. Methods...
10398666 Method for treating cancer with low molecular weight components of aurin tricarboxylic acid complex  
A method of preventing and/or treating cancer in a subject is provided. The method includes administering to the subject a composition comprising an effective amount of an active agent selected...
10398661 Methods for classifying a cancer as susceptible to TMEPAI-directed therapies and treating such cancers  
The invention provides methods for classifying a cancer as susceptible to transmembrane prostate androgen induced (TMEPAI)-directed therapies, and methods for treating such cancers. The field of...
10398658 Oxprenolol compositions for treating cancer  
The present invention relates to compositions of S-enantiomer enriched oxprenolol and their use in treating cancer and treating or preventing, in cancer patients, cachexia, body weight loss, lean...
10393747 Diagnostic method for gastric cancer  
This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in...
10393746 Kit for immunological detection of TNF-alpha, sTNFR1 and IL-8 in prostate cancer  
The disclosure provides methods of using biomarkers to improve diagnosis of forms of prostate. The method includes testing a biological sample from an individual for a interleukin-8 (IL-8), Tumor...
10393745 Method for the diagnosis and prognosis of cancer  
The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises...
10393744 Peptides for targeting colorectal cancer, and medical use thereof  
Provided is a peptide for targeting colorectal cancer, a composition for diagnosing radioresponsiveness-dependent prognosis of colorectal cancer using the peptide, and a drug delivery use of the...
10392667 Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients  
The present invention features methods, devices, and kits for predicting the sensitivity of a patient to a compound or medical treatment, such as fulvestrant.
10392444 Tumor antigen specific antibodies and TLR3 stimulation to enhance the performance of checkpoint interference therapy of cancer  
The present disclosure relates to a method for inhibiting cancer tumor growth in a patient by administering to the patient a therapeutic monoclonal antibody specific for a tumor associated antigen...
10392443 Diagnostic and therapeutic tool for cancer  
Disclosed is a method for determining the likelihood of the presence or progression of a hepatocellular carcinoma in a subject, comprising determining the level of extracellular form of Agrin in...