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9572822 Treatment of cervical cancer with gold(I) complexes  
Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium...
9572808 Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer  
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
9572799 Pyrazolopyridine derivatives for use in the treatment of bladder cancer  
The invention relates to the use of compounds corresponding to formula (I), or a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.
9569586 Algorithm for modification of somatic cancer evolution  
Most clinically distinguishable malignant tumors are characterized by specific mutations, specific patterns of chromosomal rearrangements and a predominant mechanism of genetic instability. It has...
9568483 Molecular subtyping, prognosis and treatment of prostate cancer  
Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN...
9568476 Diagnosis and treatment of breast cancer  
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to...
9567642 Methods and products related to targeted cancer therapy  
The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of...
9567641 Combination therapy for the treatment of cancer using an anti-C-met antibody  
A target substance used for combination treatment with an anti-c-Met antibody, a pharmaceutical composition for combination administration for preventing and/or treating cancer including an...
9567640 Utility of B-RAF DNA mutation in diagnosis and treatment of cancer  
The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting...
9567586 EpCAM aptamer for detection of cancer stem cells  
The present disclosure relates to an RNA aptamer and uses thereof, in particular, an aptamer which specifically bind to EpCAM and which demonstrates superior tumor penetrating ability.
9567402 Internalizing human monoclonal antibodies targeting prostate and other cancer cells  
In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer...
9567369 Method of treating metastatic cancer  
A method of treating metastatic cancer, comprising the steps of (a) treating a metastatic cancer patient with an isolated therapeutic Cystatin C peptide, and (b) observing a reduction in tumor...
9567326 Pyrimidine compounds for the treatment of cancer  
Described are compounds of Formula I or Formula II: wherein: ring A is a 5- or 6-membered heteroaryl group; dashed lines are optional double bonds; X is N or O; Y is a carbon atom or an S or N...
9567306 Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer  
Compounds and compositions are provided which inhibit MIF. Methods of treatment of melanoma and colon cancers are also provided.
9566348 Methods and compositions for the treatment of cancer and infectious disease using alpha(2) macroglobulin-antigenic molecule complexes  
The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes and compositions...
9566323 Vaccine for cervical cancer  
The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human papillomavirus (HPV) type 16, a L1...
9566309 Compositions for treatment of cancer-related fatigue  
Disclosed are compositions containing extracts of (a) Panax ginseng C. A. Mayer, (b) Zingiber officinale, (c) Echinacea angustifolia and (d) Silybum marianum or the phospholipid complex of silybin...
9566282 Methods for identifying and validating selective anti-cancer stem cell agents  
Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a...
9566280 Combination therapies and methods of use thereof for treating cancer  
Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are...
9565852 Methods and reagents for maintaining the viability of cancer cells in surgically removed tissue  
A composition and method for generating reagents and the composition of these reagents for the stabilization and preservation of viability of cancer tissue which has been surgically excised and...
9562906 Methods for detection of gastric cancer  
The invention is directed to non-invasive methods of detecting gastric cancer in an individual in need thereof comprising determining an expression level of inter-alpha-trypsin inhibitor heavy...
9562905 Method for detection of, or the risk of, bladder cancer  
Methods for the detection of, or the risk of, bladder cancer in a patient, comprising assaying for the presence of a combination of at least two biomarkers selected from CEA, VEGF, IL-8, NGAL,...
9562891 Method for screening patient-specific anti-cancer agent using limiting dilution assay  
A screening method is described for selecting patient-specific anti-cancer agents reflecting individual genetic properties, in a precise and rapid manner, using an extremely small amount of cancer...
9562237 Reduction of TGF beta signaling in myeloid cells in the treatment of cancer  
Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing TGFβ signaling, for example, by reducing TGFβ receptor II expression in myeloid cells....
9562219 Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer  
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and...
9562051 Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer  
The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds,...
9562047 Pyrazolopyrimidine compounds for the treatment of cancer  
Compounds of Formula I are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof.
9562035 Benzamide derivative useful as FASN inhibitors for the treatment of cancer  
The present invention is directed to benzamide derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related...
9561290 Functionalized thieno-indole derivatives for the treatment of cancer  
The invention relates to new functionalized thieno-indole derivatives of formula (I) or (II) which have cytotoxic activity and are useful in treating diseases such as cancer and cellular...
9561274 Treatment and prevention of cancer with HMGB1 antagonists  
Embodiments provided herewith relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant...
9561238 Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy  
The present invention relates to a method of treating or preventing estrogen-suppressed tumors in a mammal, said method comprising the administration of a therapeutically effective amount of an...
9561237 Bis-(triethylphosphine)platinum(II) complexes with thiones as anti cancer agents  
Platinum(II) complexes having mixed ligands as anticancer agents. The central platinum atom is coordinated by two phosphine ligands and two heterocyclic thione ligands. Each heterocyclic thione...
9561215 BAX-activating cancer therapeutics  
The pro-apoptotic Bcl-2 protein Bax initiates apoptosis in almost all apoptotic paradigms. Agents facilitating disruptive Bax insertion into mitochondrial membranes have potential as cancer...
9557332 Glucose-sensitive nanoparticle for cancer diagnosis and therapy  
Disclosed are glucose-sensitive nanoparticles which includes a phenylboronic acid derivative and a biocompatible polymer, and is prepared as an amphiphilic conjugate having chemical binding...
9556491 Utility of B-RAF DNA mutation in diagnosis and treatment of cancer  
The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting...
9556437 FAT1 gene in cancer and inflammation  
The present invention demonstrates for the first time that FAT1 plays an important role in modulating PDCD4 expression, which in turn regulates AP-1 dependent transcription, controls processes...
9556271 Anti-CEACAM1 recombinant antibodies for cancer therapy  
Provided herein are recombinant monoclonal antibodies and antigen-binding portions thereof useful in inhibiting CEACAM1 in tumor cells, and methods of their use in anti-tumor proliferation and...
9556264 Humanized anti-epiregulin antibody, and cancer therapeutic agent comprising said antibody as active ingredient  
The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed...
9556256 Inhibition of cancer metastasis  
P-Selectin on platelets and endothelium binds cell surface chondroitin sulfate (CS) proteoglycans, which are abundantly and stably expressed on the surface many cancer cells. Binding of the cancer...
9556249 Neuregulin antagonists and use thereof in treating cancer  
The invention provides neuregulin antagonists and methods of using the neuregulin antagonists in delaying the time to tumor recurrence or preventing resistance of cancer cells to treatment with a...
9556113 Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment  
The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for...
9555110 Anti-alpha-V integrin antibody for the treatment of prostate cancer  
The invention is directed to the treatment of prostate cancer by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to...
9555058 Antigen presenting cancer vaccine  
The disclosure provides reagents, methods, and kits, for treating melanoma. The reagent encompasses interferon-gamma (IFN-gamma) responsive melanoma cells, where the cells are autophagic and...
9555049 Arene ruthenium (II) derivatives containing iminophosphorane ligands and their use in cancer therapy  
A method for providing a therapeutic benefit for a subject having a cancer is provided. A compound with an arene ruthenium (II) compound with an iminophosphorane ligand is administered to the subject.
9555042 Treatment for pancreatic cancer  
The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt...
9555034 Compositions and methods for treating skin cancer associated diseases  
The invention provides compositions and methods for treating skin cancer associated diseases. Specifically, the invention relates to topically administering a signaling pathway inhibitor or a...
9555011 Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics  
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic...
9552457 Reprogramming effector protein interactions to correct epigenetic defects in cancer  
Methods of “reprogramming” epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset...
9551713 Use of a panel of urinary cytokines to predict response to BCG therapy for bladder cancer  
Methods for predicting cancer recurrence following a BCG immunotherapy are provided. In some aspects, cytokine levels from a patient are measured before and after a BCG therapy and the changes in...
9551712 Volatile organic compounds as diagnostic markers for various types of cancer  
The present invention provides sets of VOCs for breath analysis. Methods of use thereof in diagnosing, monitoring or prognosing breast cancer, head and neck cancer, prostate cancer or colon cancer...