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9896732 Method of diagnosing cancer comprising detection of the methylation signature in the hTERT promoter  
A method of diagnosing cancer in a mammal is provided. The method includes the steps of determining in a nucleic acid-containing sample from the mammal the degree of DNA methylation of a target...
9896730 Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment  
The present invention provides diagnostic methods for assessing the EMT status of tumor cells, and for predicting the effectiveness of treatment of a cancer patient with an EGFR or IGF-1R kinase...
9896445 Heterocyclic inhibitors of ERK1 and ERK2 and their use in the treatment of cancer  
The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful for...
9896420 N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation  
The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear...
9895441 Methods of treating cancer using PD-L1 axis binding antagonists and VEGF antagonists  
The present invention describes combination treatment comprising a PD-1 axis binding antagonist, chemotherapy and optionally a VEGF antagonist and methods for use thereof, including methods of...
9895438 Treatment of cancer with naltrexone  
The present invention provides novel therapeutic applications of low dose naltrexone (LDN). Said applications have been determined in light of the discovery by the present inventors that...
9895430 Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer  
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and...
9895415 Immunotherapy against several tumors including gastrointestinal and gastric cancer  
A method of treating a patient who has gastric cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the...
9895414 Inhibition of cancer growth and metastasis  
The present invention relates to methods for treating or preventing cancer and metastasis. More particularly, the present invention relates to methods for treating or preventing cancer by...
9895390 Methods and assays for combination treatment of cancer  
The technology described herein is directed to the treatment of cancer, e.g. methods and assays relating to selecting and administering a chemotherapy with or without an EZH2 inhibitor.
9895365 Combination therapy for cancer treatment  
Combination therapies for treating cancer comprising administration of a topoisomerase-1 inhibitor and a PARP inhibitor are provided. The topoisomerase-1 inhibitor can be delivered as a liposomal...
9895363 Methods for modulating function of proliferating cell nuclear antigen (PCNA) and treating cancer with PCNA-targeting compounds  
Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include...
9895351 Indomethacin analogs for the treatment of castrate-resistant prostate cancer  
Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin...
9895338 Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it  
A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing...
9895324 Halogenated diarylacetylenes and methods of treating cancer  
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LS174T colon...
9895312 Nanoliposomal c-MYC-siRNA inhibits in vivo tumor growth of cisplatin-resistant ovarian cancer  
The present invention discloses c-MYC-siRNA formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-MYC with small interfering RNA (siRNA)...
9892510 Method and apparatus for automatic cancer diagnosis using percentage scoring  
Certain aspects of an apparatus and method for automatic ER/PR scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying a positive stained nucleus in a...
9892229 Diagnosis and risk stratification of bladder cancer  
The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of: (A) assessing the subject's likelihood of having bladder cancer by: i....
9891224 Biomarkers for aggressive prostate cancer  
The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing aggressive prostate cancer. In one embodiment, a...
9891223 Method of assaying leukocyte elastase inhibitor for the in vitro diagnosis of colorectal cancer  
The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Leukocyte Elastase Inhibitor tumor marker in a biological sample taken...
9891222 Methods and compositions for identification and quantification of ENOX2 transcript variants as indications of cancer presence in blood serum and other body fluids based on gold or silver nanoparticle formation  
The present invention includes a semi-quantitative method for the detection of ENOX2 transcript variants from one or more anti-ENOX2 antibody-binding spots on a blot comprising the steps of:...
9890429 Compositions, kits, and methods for the identification, assessment, prevention, and therapy of cancer  
The present invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating cancer (e.g., hematological malignancies in humans). A variety of biomarker...
9890215 Vista modulators for diagnosis and treatment of cancer  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
9890196 Ezrin assay method for the in vitro diagnosis of colorectal cancer  
A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer...
9890187 Prototype systems of theranostic biomarkers for in vivo molecular management of cancer  
The present invention relates to a theranostic system comprising a beacon and a compound selected from the group consisting of a quinazoline-based tyrosine kinase inhibitor and a natural product....
9890127 Compounds and compositions for the treatment of cancer  
Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.
9890106 Anti-cancer lead molecule  
Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative ‘A’ (Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer...
9889212 Preparation method for magnetic composite for treating and diagnosing cancer  
A preparation method for a magnetic composite for treating and diagnosing cancer. The method may include a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated...
9889201 Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents  
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of...
9889193 Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-deltaC virus) in cancer therapy  
The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been...
9889180 Method of treating cancer  
The present invention relates to a pharmaceutical composition comprising a histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) inhibitor and an enhancer of interferon-gamma...
9889169 Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor  
Described is a pharmaceutical composition comprising (a) a parvovirus and (b) an Bcl-2 inhibitor and the use of said composition for treatment of cancer, e.g., a solid tumor. Preferred inhibitors...
9889159 Peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
9889155 Enhancer of anti-tumor effect of anti-cancer agent  
An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue....
9889141 Combined inhibition of the vitamin D receptor and poly(ADP) ribose polymerase (PARP) in the treatment of cancer  
Methods for treating tumors comprise contacting tumor cells expressing the vitamin D receptor with a vitamin D receptor ligand that inhibits homologous recombination in the tumor cells, and...
9889138 Method for treating cancer  
The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered...
9889120 Combination drug therapies for cancer and methods of making and using them  
In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices for treating, preventing or ameliorating a tumor or a cancer, and...
9889105 In vivo method for treating, inhibiting, and/or prophylaxis of cancer, such as pancreatic cancer  
An in vivo method of inhibiting tumor growth, specifically pancreatic cancer, includes administering to a subject in need thereof an effective amount of a compound, composition, and/or a...
9889101 Therapeutic treatment of cancer and dysplasia of the cervix or vagina using estrogen antagonists  
A method for treatment of cervical or vaginal cancer and their associated dysplasia, including the steps of identifying a human cervical or vaginal cancer and/or dysplasia patient, administering...
9889092 Low density lipoprotein nanocarriers for targeted delivery of omega-3 polyunsaturated fatty acids to cancer  
An LDL nanocarrier is an effective and appropriate transporter for DHA in biological systems. The LDL-DHA nanoparticle was shown to be preferentially cytotoxic to malignant liver cells. These...
9889082 Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH  
This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a...
9885720 Methods for detecting and treating cancer  
The invention generally features compositions and methods for the diagnosis, treatment, and monitoring of neoplasia in a subject, as well as methods of treatment selection.
9885719 Composition comprising lysophosphatidylcholine and homocysteic acid for ovarian cancer diagnosis and method using the same  
Provided are methods of treating a subject for of ovarian cancer, the method including using lysophosphatidylcholine (16:0) and homocysteic acid, which are low-mass ions present in biological...
9885718 Specific biomarker set for non-invasive diagnosis of liver cancer  
Cells within liver tumour mass comprise a unique set of proteins/tumour antigens when compared to the normal liver tissues epithelial cells juxtaposed to the tumour. The presence of tumour...
9885704 Reagents and methods for cancer treatment and prevention  
The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or...
9885044 Polynucleotides and methods for inhibiting cancer cells  
The present invention provides methods of inhibiting or reducing the growth of cancer cells in a subject, by administering a therapeutic effective amount of Puf-A inhibitor, whereby the symptoms...
9885031 Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells  
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of...
9884874 Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer  
Provided is a novel compound having bromodomain and extra terminal domain (BET) protein inhibiting activities, and a pharmaceutical composition comprising the same which can be useful for...
9884098 Multivalent breast cancer vaccine  
Compositions and methods for immunization against human breast cancer are disclosed. In one embodiment the multivalent antigenic composition is provided comprising immunogenic polypeptides...
9884054 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer  
Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.