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9493839 Non-invasive cancer diagnosis  
A non-invasive method for the diagnosis of adenocarcinoma or precursor lesions in a female subject and a kit for performing such diagnosis are provided. The method comprises the steps of (1)...
9493775 Inhibition of the glycine cleavage system for treatment of cancer  
In some aspects, methods of inhibiting survival or proliferation of a tumor cell are provided, the methods comprising inhibiting the glycine cleavage system (GCS) of the tumor cell. In some...
9493740 Immunotherapy of cancer using genetically engineered GD2-specific T cells  
The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is...
9493566 Antibodies to integrin AVB6 and use of same to treat cancer  
The invention provides antibodies that specifically bind to integrin αvβ6. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting αvβ6.
9493532 Compositions for cancer therapy using mutant light molecules with increased affinity to receptors  
Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse...
9493501 Methyltransferase inhibitors for treating cancer  
Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure and are useful in the treatment of cancer and similar diseases associated with inappropriate...
9493466 Treatment of cancer with TOR kinase inhibitors  
Provided herein are methods for treating or preventing a solid tumor, non-Hodgkin lymphoma or multiple myeloma in a patient, comprising administering an effective amount of a TOR kinase inhibitor...
9493431 Apoptosis-inducing agent for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9493419 Quinoline derivatives as anti-cancer agents  
Quinoline derivatives showing anticancer activities against cancer cell lines of hepatocellular carcinoma (Hep3B), lung carcinoma (A549), esophageal squamous cell carcinoma (HKESC-1, HKESC-4 and...
9492540 Methods for treating cancer using anti-PD-1 antibodies  
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the...
9492497 Peptides for the treatment of cancer  
The present invention relates to an isolated peptide for use in the treatment of cancer consisting of 12 to 50 amino acid residues comprising—at least two beta-strands, or—at least two...
9492478 Encoded bioelectronic method and system and calcium treatment for slaying cancer by rapid triggering of cellular apoptosis and karyorrhexis  
A bioelectronic medical method and system for rapidly destroying living cancer cells and the tumors they create including metastatic off-spring of such tumor(s) regardless of their location within...
9492472 Compositions and methods of treating cancer  
A method of inhibiting neoplastic, cancer, and/or tumorgenic cell proliferation, cell growth and motility in a subject includes administering to a cancer cell expressing Pro-PrP and FLNa a...
9492470 Use of HMGA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells  
Elevated high mobility group A (HMGA) protein expression in human cancer cells, and especially human pancreatic cancer cells, is correlated with resistance to the chemotherapy agent gemcitabine....
9492442 Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan  
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the...
9492418 Inhibitors of PFKFB3 for cancer therapy  
Compounds used to inhibit glycolytic pathway small molecule kinase 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB) are set forth; these inhibitors can be used in the treatment of...
9492417 Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer  
The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the...
9492414 Treatment and diagnosis of colon cancer  
The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
9492403 Method of treating overactive bladder, not due to cancer, by administering at least one jasmonate  
A formulation or composition contractility comprising jasmonate for modulating bladder and/or treating bladder dysfunction, particularly an overactive bladder in a mammal, particularly a human and...
9488655 Biomarkers for detection of early- and late-stage endometrial cancer  
Biomarker proteins that can be used in the diagnosis of early-stage endometrial cancer are described. Methods of screening for endometrial cancer, as well as methods of detecting and monitoring...
9488654 Methods for predicting response of triple-negative breast cancer to therapy  
The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative...
9488652 Detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition in body fluids of cancer patients  
The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods. According to the present invention said method...
9487781 Compositions and methods for treatment of ovarian cancer  
The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to...
9487777 RNAi probes targeting cancer-related proteins  
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder...
9487586 Methods for cancer management targeting Co-029  
The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer...
9487582 Methods for treating pancreatic cancer  
The present disclosure is directed to methods of treating pancreatic cancer in subject using cancer with antibodies that specifically bind to progastrin.
9487540 Compound for inhibiting the growth and proliferation of human liver cancer cells and method for synthesizing it  
The compound “2-((4-nitrophenyl)amino)-6,7,8,9-tetrahydro-3H-cyclohepta[4 ,5]thieno-[2,3-d]pyrimidin-4(5H)-one” and method of synthesizing it, wherein the compound is effective to inhibit the...
9486545 Method of screening for colon cancer using biomarkers  
The present invention relates to biomarkers for colon cancers, specifically adenomas and adenocarcinomas in the GI tract. The inventors have discovered that the expression and/or overexpression of...
9486536 Pro-drug form (P2PDOX) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer  
Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable...
9486512 In situ antigen-generating cancer vaccine  
The invention provides compositions and methods for utilizing scaffolds in cancer vaccines.
9486490 Composition for preventing or treating cancer containing extracts of artocarpus altilis fruits, leaves, or stems, or fractions thereof as active ingredients  
The present invention relates to a pharmaceutical composition for preventing and treating cancer which comprises the extracts of Artocarpus altilis fruits, leaves, or stems, or the fractions...
9486471 Combination therapy for the treatment of cancer  
Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic...
9486467 Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin  
The present invention includes methods for treating or preventing a cancer in a mammal comprising administering to the mammal a therapeutically effective amount of a macrolide antibiotic such as...
9486466 Veliparib in combination with carboplatin for the treatment of triple negative breast cancer  
The invention relates to a method for the treatment of triple negative breast cancer in a subject, comprising administering to the subject an effective amount of...
9486449 Cancer therapy  
The subject invention provides for cancer therapy.
9486444 Anti-cancer compound  
Anti-cancer compounds include N-arylmethylidene piperidones having structural formula I: where R is a hydrogen, halogen, methyl, methoxy, or nitro group, or a pharmaceutically acceptable salt thereof.
9486434 Method for delivery and use of isothiocyanates for prophylaxis and/or therapy of bladder cancer  
Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a...
9481885 Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis  
The present invention provides materials and methods related to the discovery that tumor secreted miR-21 and miR-29a can function by binding as ligands to receptors of the Tolllike receptor...
9481728 Compositions and methods for treatment of cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
9481693 Mixed ligand gold(III) complexes as anti-cancer agents  
Gold(III) complexes with mixed ligands as anticancer agents. The gold(III) cations are coordinated to bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and a...
9480754 Phospholipid ether analogs as cancer-targeting drug vehicles  
The present invention is directed to therapeutic compounds capable of targeting cancer cells and cancer stem cells. The present invention is further directed to compositions comprising these...
9480745 Targeted treatment of anerobic cancer  
The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in...
9480725 Fermented wheat germ proteins (FWGP) for the treatment of cancer  
The present invention provides compositions comprising the component of fermented wheat germ extract (“FWGE”) active in reducing, inhibiting or preventing the proliferation of cancer cells and/or...
9480664 Compositions and methods for treating cancer  
Compositions containing one or more COX inhibitors in combination with one or more antagonists of 20-HETE (20-hydroxyeicosatetraeonic acid), and optionally a pharmaceutically acceptable excipient...
9480653 Protocells and their use for targeted delivery of multicomponent cargos to cancer cells  
Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to...
9476883 Cellular recognition conjugates and methods of use for the histological analysis of cancer tissue using MALDI-MS imaging  
Disclosed are conjugates that can bind to one or more site on cancer cell surface, for example, surface proteins, compound specific receptors and carbohydrates that comprise the surface of...
9476882 Methods and compositions for diagnosing and treating cancer  
The invention provides assays, methods, systems, compositions, and kits for diagnosing and treating cancer.
9476871 System and method for automated determination of the relative effectiveness of anti-cancer drug candidates  
A computer system is provided for determining the relative effectiveness of anti-cancer drugs. The interface has selectable options, including an option to manage drug testing parameters, and...
9476100 Methods for diagnosing bladder cancer  
Methods and kits for identification of bladder cancer in a subject based on alterations in DNA methylation at selected genomic loci are provided.
9476098 Multigene prognostic assay for lung cancer  
The present invention provides methods for providing a prognosis for lung cancer using a panel of eleven molecular markers that includes BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3,...