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9198891 Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase  
The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first...
9198597 Leading-edge cancer treatment  
Kits and methods for the treatment of certain types of cancers, specifically various primary brain cancers. In some embodiments, treatment is directed toward the known areas of cancer cell...
9198579 Method and device for the optical spectroscopic identification of cervical cancer  
A medical examination device used for the detection of pre-cancerous and cancerous tissue has an illumination source, a visualization unit, a contacting optical probe, a detector and a process...
9194872 Potentiation of nanopharyngeal cancer radiotherapy by inhibitors of leukemia inhibitory factor  
A method for evaluation of cancer diagnosis following cancer radiotherapy, comprising: providing a serum sample of a cancer patient prior to the cancer radiotherapy; and measuring a leukemia...
9194862 Compositions and methods for determining cancer stem cell self-renewal potential  
In alternative embodiments, the invention provides compositions and methods for determining the self-renewal potential of a cancer stem cell (CSC) through analysis of the cross-talk between cell...
9194005 Methods and biomarker for evaluating cancer metastasis, pharmaceutical composition for inhibiting cancer metastasis, and method for analyzing secretome  
The invention relates to methods and biomarker for evaluating cancer metastasis, pharmaceutical composition for inhibiting cancer metastasis, and method for analyzing secretome. By combining a...
9194003 MITF as a marker for predisposition to cancer  
The present invention relates to a mutant of MITF which is useful as a marker for predisposition to the development of cancer and to uses thereof in diagnosis and preventive treatments,...
9193970 Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer  
The present disclosure relates generally to cancer and particularly to breast cancer including estrogen sensitive, estrogen resistant and triple negative breast cancer (TNBC), and to methods of...
9193794 Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same  
The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a...
9193782 Use of the SPARC microenvironment signature in the treatment of cancer  
The invention provides multiparametric anti-SPARC antibody-based techniques for predicting the response to chemotherapy.
9193719 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities  
Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR...
9193687 Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents  
The present disclosure relates to new DNA-directed alkylating agents and water-soluble N-mustard agents with improved chemical stability and anti-tumor therapeutic efficacy.
9192667 Method of treating cancer by administering CSF-1R antibodies and a TLR9 agonist  
The present invention relates to the combination therapy of antibodies against human CSF-1R with a TLR9 agonist.
9192666 Method of treating cancer using anti-c-Met antibody and FGFR inhibitor combination therapy  
Provided is a method for prevention or treatment of a cancer, comprising co-administering (a) an FGFR inhibitor and (b) an anti-c-Met antibody or antigen-binding fragment thereof to a subject in...
9192656 Methods and compositions for the treatment of cancer  
The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent...
9192627 Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy  
In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments,...
9187787 Method of diagnosing and treating cancer  
A method of diagnosing and treating a glioma or a breast cancer is disclosed. The method of diagnosing comprises analyzing an amount or activity of heterogeneous nuclear ribonucleoprotein A2/B1...
9187786 Ovarian cancer methylome  
The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypermethylation of a gene or a regulatory...
9187733 Anti-cancer adenoviruses  
Anti-cancer adenoviruses, methods of use and methods of making the same are provided herein.
9187526 Peptide based inhibition of caPCNA interaction in cancer  
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (caPCNA, also known as csPCNA) or from nmPCNA-interacting proteins interfere with intracellular protein-protein...
9187485 Methods and compositions for the treatment of cancer and related hyperproliferative disorders  
The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general...
9187469 Morpholinylbenzotriazines for use in cancer therapy  
The invention relates to compounds of the formula (I) in which R1, L and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof,...
9187454 Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof  
The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of...
9186373 SiRNA against Cbl-b and optionally IL-2 and IL-12 for use in the treatment of cancer  
The invention relates to a method for the immune activation of NK cells by the reduction or inhibition of the Cbl-b function in said cells. This stimulates the congenital immune system and thus...
9186370 Methods and compositions for the treatment of cancer  
Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for modulating the activity of the Hedgehog pathway.
9186339 Use of transcriptome modifying agents and chemotherapy or radiotherapy against cancer  
The use of transcriptome-modifying agents is disclosed in order to prevent malignant cells from undergoing the necessary genetic changes in order to combat cell insult and survive chemotherapy or...
9182415 Use of IMP3 as a prognostic marker for cancer  
Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a...
9182403 Kits for and methods of differential staining of cervical cancer cells and/or tissues  
Provided are methods and kits for staining cervical cell sample by contacting the cervical cell sample with a Ficus elastics plant extract, staining the cervical cell sample with New Fuchsin, and...
9182387 Methods for cancer detection, diagnosis and prognosis  
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell...
9182383 Biomarkers for the diagnosis and treatment of pancreatic cancer  
Compositions and methods for use in methods and kits for the detection of an increased risk of pancreatic cancer are provided. Cyst fluid samples isolated from patients that are positive for at...
9181589 Molecular-based method of cancer diagnosis and prognosis  
A gene profiling signature for diagnosis and prognosis of cancer patients is disclosed herein. In one embodiment, the gene signature includes 32 or 79 cancer survival factor-associated genes....
9181588 Methods of treating breast cancer with taxane therapy  
The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane...
9181348 Pharmaceutical composition for treatment and/or prophylaxis of cancer  
An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional...
9181334 Pharmaceutical composition for treatment and/or prophylaxis of cancer  
This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer....
9181265 Substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines as anti-angiogenic and anti-cancer agents  
Novel phenazine derivatives of formula (I) are disclosed. In particular, substituted 2,3-dihydro-1H-benzo[a]pyrano[2,3-c]phenazines are disclosed. The compounds can be used as anti-angiogenic...
9181223 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities  
Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR...
9180214 Gonadotropin-releasing hormone receptor-targeting peptides and their use to treat and diagnose cancer  
The present invention is directed to novel non-invasive diagnostic tools/compounds to image and treat cancers, especially cancers which overexpress GnRH such as breast cancer, prostate cancer and...
9180188 Pharmaceutical composition for treatment and/or prophylaxis of cancer  
It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a...
9180187 Medicament for treating and/or preventing cancer  
This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on...
9180151 Oncolytic vaccinia virus combination cancer therapy  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia...
9180136 Identification and treatment of cancer subsets  
The present invention relates to methods of selectively treating a patient with skin squamous cell carcinoma are disclosed. Specifically, the methods comprise assessing whether or not the tumor...
9180107 Combination treatment of cancer with cetuximab and tetrac  
Provided herein are compositions and methods for treating cancer by increasing the inhibitory effect of cetuximab on HIF1α expression by administering cetuximab in combination with anti-angiogenic...
9180106 Sigma receptors ligands with anti-apoptotic and/or pro-apoptotic properties, over cellular mechanisms, exhibiting prototypical cytoprotective and also anti-cancer activity  
The present invention involves new and original sigma receptors ligands: (Mono- or dialkylaminoalkyl)-γ-butyrolactones, their analogues aminotetrahydroturanes, the (1-adamantyl)benzene...
9176236 Device for measuring radiation intensity of small sealed radiation source for cancer therapy  
The invention provides a radiation intensity measuring apparatus for each of small sealed radiation sources for cancer therapy that is capable of measuring multiple cartridges. The apparatus...
9175351 Means and methods for molecular classification of breast cancer  
The invention relates to a method of typing a sample from a breast cancer patient. More specifically, the invention relates to a method for classification of breast cancer according to the...
9175350 EML4-ALK translocations in lung cancer  
The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are...
9175090 Methods of using an antibody to inhibit WNT-mediated signaling in cancer  
The present invention is directed to monoclonal antibodies and fragments thereof directed to LRP5/6 that find use in the prevention and treatment of cardiac remodeling and cancer. Also disclosed...
9175088 Identification of tumor-associated markers for diagnosing or monitoring ovarian cancer  
The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which...
9175074 Pharmaceutical composition for treatment and/or prophylaxis of cancer  
An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional...
9175001 [1,3] dioxolo [4,5-g] [1,2,4] triazolo [1,5-a] quinoline derivatives as inhibitors of the late SV40 factor (LSF) for use in treating cancer  
The present invention relates generally to [1,3]dioxolo[4,5-g]quinoline-6(5H)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives and/or compositions for use in inhibiting,...