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9164097 Formulations targeting IGFBP7 for diagnosis and therapy of cancer  
The invention relates to antibodies or fragments thereof specific for insulin-like growth factor binding protein-7 (IGFBP7). A method of raising anti-IGFBP7 single domain antibodies is also...
9164084 Methods for determining aggressiveness of a cancer and treatment thereof  
The invention generally relates to methods for determining aggressiveness of a cancer and treatment thereof. Certain aspects of the invention provide methods that involve conducting an assay on a...
9163261 Adeno-associated virus 2/8—micro RNA-101 therapy for liver cancer  
Adeno-associated virus 2/8-microRNA-101(AAV2/8-miR-101) therapy for liver cancer is provided. In particular, the invention provides a recombinant AAV 2/8 vector, comprising mutated capsid, for the...
9163236 Pharmaceutical composition comprising NANOG SHRNA, and method of using NANOG SHRNA to treat cancer  
The present description relates to an inhibitory RNA molecule, comprising an oligonucleotide that selectively knocks down expression of either Nanog or a Nanog pseudogene, a vector capable of...
9163085 Anti-OX40 antibodies and methods of treating cancer  
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40...
9163048 Multi-functional nucleic acid-based anti-cancer drug capable of targeting and therapy, method for preparing same and anti-cancer composition comprising same  
The present invention relates to a multi-functional nucleic acid-based anti-cancer drug in which the anti-cancer drug is physically bound to a linear nucleic acid having a thiol group at 5′...
9162994 1,2,4-thiazoloidin-3-one derivatives and their use in the treatment of cancer  
According to the invention there is provided a compound of formula (I) wherein: A represents C(═N—W-D) or S; B represents S or C(—NH—W-D); when: A represents C(═N—W-D) and B represents S then the...
9161974 Methods and compositions using listeria for adjuvant treatment of cancer  
Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of...
9161944 Method for preventing cancer metastasis  
The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention...
9157976 CEST MRI methods for imaging glutaminolysis in cancer  
CEST imaging technique and MR scanning are used as an MRI method for measuring glutaminase mediated tumors. The method takes advantage of the fact that glutamine does not exhibit a significant...
9157862 Optical spectroscopic device for the identification of cervical cancer  
A medical examination device used for the detection of pre-cancerous and cancerous tissue has an illumination source, a visualization unit, a contacting optical probe, a detector and a process...
9157840 Multiple separation device and method of separating blood cancer cell  
The present inventive concept provides a multiple separation device and a method of separating a blood cancer cell using the same. In the device and the method, a blood sample is put in a fine...
9157126 Salivary protein biomarkers for human oral cancer  
The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a...
9157124 Systems and methods for diagnosing a predisposition to develop colon cancer  
Systems and methods for diagnosing or characterizing a predisposition to colon cancer are provided. Cell nuclei may be evaluated for the presence or quantity of gamma-H2AX foci. Nucleic acids may...
9157123 Genetic amplification of IQGAP1 in cancer  
We examined IQGAP1 copy gain and its relationship with clinicopathologic outcomes of thyroid cancer and investigated its role in cell invasion and molecules involved in the process. We found...
9157122 Method of diagnosing cancer and reagents therefor  
The present invention provides methods for diagnosis and monitoring the efficacy of treatment of a cancer. More particularly, the methods of the invention comprise detecting an enhanced degree of...
9156898 Treatment of cancer and compositions  
The invention discloses a method of identifying a gene associated with stage III primary cancer or lymph node metastasis. The genes so identified include CAV1, CST3, LIMK1, MMP2, MMP15, VEGF,...
9156878 Treatment of prostate cancer  
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen...
9156856 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9156853 AKT inhibitor compounds for treatment of cancer  
The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to...
9155911 Ion source method and apparatus used in conjunction with a charged particle cancer therapy system  
As part of a charged particle cancer therapy system, a negative ion source is used to generate and accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of...
9155872 Drug delivery device for ovarian cancer  
A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular...
9155774 Scaffold-kinase interaction blockades and uses thereof in treating cancer  
Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for...
9155761 Method for the treatment of cancer  
The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of,...
9155723 Anti-CXCR4 as a sensitizer to cancer therapeutics  
Inhibition of CXCR4 can inhibit tumor growth and metastasis during certain therapeutic windows. Disclosed are novel methods for treating and preventing cancer in a subject related to...
9151760 Isolation and use of melanoma cancer stem cells  
A set of markers for melanoma cancer stem cells are provided. The cells can be prospectively isolated or identified from primary tumor samples, and possess the unique properties of cancer stem...
9150925 SNP panels for predicting prostate cancer-specific mortality  
Provided are SNP panels and methods that employ SNP panels for predicting prostate cancer-specific mortality in a human patient. Exemplary SNP panels presented herein comprise one or more of the...
9150859 Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features  
MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell...
9150857 Targeting microRNAs for the treatment of liver cancer  
Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide...
9150531 Tricyclic lactones for treatment of cancer  
The present invention discloses novel compounds useful for the inhibition of IL-6/STAT signaling and/or PI3K/NF-κB signaling in the treatment of associated diseases or conditions, e.g. cancer. A...
9150495 Polyamine transporter selective compounds as anti cancer agents  
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel...
9149526 Suppression of cancer growth and metastasis using nordihydroguaiaretic acid derivatives with metabolic modulators  
Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two...
9149523 Compositions and methods for treating cancer and neurodegenerative diseases  
The present invention relates to compositions and methods for regulating ROC-mediated death-associated protein kinase (DAPk) activity. The compositions and methods of the present invention are...
9149516 Polyvalent conjugate vaccine for cancer  
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated...
9149485 Methods and compositions related to glucocorticoid receptor antagonists and breast cancer  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other...
9149449 Compositions and methods for the treatment of cancer  
The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor having the structure according to...
9146239 Method of judging risk of cancer recurrence and computer program  
There is provided a method of judging a risk of cancer recurrence based on the activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and...
9146238 Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants  
The invention features diagnostic and therapeutic methods and compositions featuring androgen receptor variant proteins and nucleic acid molecules whose expression is increased in androgen related...
9145559 Methods of treating cancer  
A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an agent which induces a...
9145554 Cancer therapy method  
This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer...
9145446 Conjugate comprising P21 protein for the treatment of cancer  
The P21 protein is used as a medicament in the treatment of cancer. A conjugate comprises a first region comprising the P21 protein, or a homologue or functional fragment thereof; and a second...
9145393 Arylpyridinone ITK inhibitors for treating inflammation and cancer  
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein Ar, R2, R4, R5,...
9144563 Treatment of triple receptor negative breast cancer  
The present invention relates to the use of a liposomal preparation for the manufacture of a pharmaceutical composition and the use of such a composition for the treatment of “triple receptor...
9140704 Serum markers associated with early and other stages of breast cancer  
Methods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided....
9139881 Method for assessing breast cancer susceptibility  
The present invention aims to provide a method for determining breast cancer susceptibility, in which a DNA copy number polymorphism associated with breast cancer susceptibility is identified and...
9139829 SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment  
Disclosed are methods of attenuating activity of the gene promoter of CIP2A. siRNAs are used to target against Ets1 and Elk1 transcriptional factors, thereby blocking the binding of Ets1 and Elk1...
9139658 Medicament for treatment cancer  
A medicament for treating cancer for use in combination therapy with an anti-HER2 antibody, which comprises amrubicin or a pharmaceutically acceptable salt thereof as an active ingredient.
9139647 Diagnosis and treatment of cancer using anti-TM4SF20 antibody  
The present invention relates to an antibody binding to a TM4SF20 protein and the diagnosis and treatment of cancer using the antibody. Specifically, the present invention provides an anti-TM4SF20...
9139563 Kinase inhibitors and method of treating cancer  
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase...
9138476 Nanoparticle-assisted ultrasound for cancer therapy  
Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be...