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8497348 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
8497296 N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells  
The invention is directed to a compound of Formula (I), wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R1 is selected from the group...
8497257 Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis  
The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a)...
8497084 15-PGDH in colon cancer  
The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the...
8492413 Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer  
New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium...
8492361 Methods for treating non-small cell lung cancer using 5-azacytidine  
The present disclosure provides methods for treating subjects having non-small cell lung cancer, wherein the methods comprise administering to the subject a cytidine analog, such as 5-azacytidine....
8492133 MIR-21 promoter driven targeted cancer therapy  
The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which...
8492104 Methods and kits to detect and monitor ovarian cancer and preeclampsia  
The present invention provides methods and kits related to a prognostic, and, in certain embodiments, diagnostic indicator for ovarian cancer which comprises measuring the level of MUC16 bound to...
8492100 Autoantibodies for protein antigens as markers for cancer of gingivo-buccal complex  
The present invention relates to identification of a set of proteins, which elicit an autoantibody response in patients with cancer of gingivo-buccal complex. Systematic comparisons of serum...
8492096 TGFBR1 expression modifies risk for colorectal cancer  
The present invention provides methods for assessing a genetic susceptibility to cancer in a subject which includes measuring allele specific expression or presence of at-risk haplotypes of TGFBR1,...
8491938 Potent inhibitory effect of zinc in combination with sulforaphane on cancer cell growth  
This invention relates to compositions comprising zinc and sulforaphane which can be used in the treatment or prevention of cancer. The invention also relates to methods of treating or preventing...
8491896 Anti-pancreatic cancer antibodies  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies...
8491895 Methods of treating cancer with human monoclonal antibodies to CTLA-4  
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid...
8487278 X-ray method and apparatus used in conjunction with a charged particle cancer therapy system  
The invention comprises an X-ray method and apparatus used in conjunction with charged particle radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the...
8487003 Treatment of cancer by administration of perfluorooctanoic acid  
The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid...
8486966 9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer  
The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative...
8486965 Pyrrolo[2,3-b]pyridine derivative and use thereof for treatment of cancer  
The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the...
8486955 Anti-cancer cyclopenta [g] quinazoline compounds  
Cyclopenta[g]quinazolines of the formula (I):—wherein: A is a group OR or NR0R1 wherein R0 and R1 are each independently hydrogen C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl, C2-4 hydroxyalkyl, C2-4 h...
8486951 Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities  
Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas,...
8486939 Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy  
Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or...
8486903 TAZ/WWTR1 for diagnosis and treatment of cancer  
We provide an anti-TAZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to...
8486656 Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine  
Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the...
8486648 Methods of detecting ovarian cancer  
The present invention provides methods of detecting ovarian cancer using biomarkers.
8486641 Compositions and methods for diagnosing and treating prostate cancer  
A method of diagnosing and determining a predisposition to prostate cancer is provided. The method comprising determining levels of MCP-1 antibodies and PSA in a sample of a subject and comparing...
8486413 Immunological compositions as cancer therapeutics  
The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In...
8486391 Cancer treatment kits using antibodies to aminophospholipids  
Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor...
8486382 Method for treating cervical cancer  
Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or...
8486127 High temperature thermal therapy of breast cancer  
A method is described for preventing breast cancer recurrence after surgical removal of a breast cancer mass. Specifically, the method is thermal treatment of breast tissue surrounding a cavity...
8481760 Inhibition and treatment of prostate cancer metastasis  
The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods...
8481740 Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture  
This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and...
8481572 Pharmaceutical compositions and methods for the treatment of cancer  
Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a...
8481533 Kinase inhibitors and method of treating cancer  
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase...
8481529 Combination cancer chemotherapy  
Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective...
8481525 Kinase inhibitors and method of treating cancer with same  
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase...
8481503 Combination cancer therapy with an AKT inhibitor and other anticancer agents  
The invention relates to combination anticancer therapy with certain Akt inhibitor and other anticancer agents such as anticancer antimetabolites, anticancer antibiotics, plant-derived anticancer...
8481497 Therapeutic agent for cancer, and method for treatment of cancer  
[PROBLEMS] To provide a technique which enables an effective antibody therapy for cancer which targets for FGFR1 without the need of using any effective antibody having high specificity and a...
8481481 Peptides and their use as carriers into cancer cells  
The use of a peptide is described as a carrier for the transport of molecules or radioisotopes into cancer cells; also described are modifications of said peptide and their use.
8481279 Methods of treating lung cancer using inhibitors anaplastic lymphoma kinase  
In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of...
8481275 Method of detecting pancreatic cancer  
To provide a method of accurately detecting pathological haptoglobin using a lectin having strong affinity and high specificity for fucose. The method of the present invention for detecting...
8481271 Vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method  
The present invention relates to the prognosis of the outcome of a cancer in a patient, which prognosis is based on the quantification of one or several biological markers that are indicative of...
8481256 In vitro method for identifying compounds for cancer therapy  
The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder...
8481038 Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins  
The present invention provides methods of treating a patient having a cancer comprising administering to the patient a soluble Fibroblast Growth Factor Receptor 1 (FGFR1) fusion protein such as an...
8481001 Combination therapies comprising quinoxaline inhibitors of P13K-alpha for use in the treatment of cancer  
The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination...
8480407 Tissue-mimicking phantom for prostate cancer brachytherapy  
A phantom for prostate cancer brachytherapy has a prostate tissue phantom shaped like a real prostate gland, a perineal tissue phantom surrounding the prostate tissue phantom, a skin tissue phantom...
8477903 Validating a compensator for use in a radiation therapy machine to treat a cancer patient  
A method of validating a compensator for use in a radiation therapy machine to treat a cancer patient involves determining a radiation treatment plan based on a compensator description file that...
8476582 Device for measuring radiation intensity of small sealed radioactive source for cancer therapy  
A radiation intensity measuring apparatus is provided for an encapsulated sealed radioactive source for brachytherapy, which is capable of measuring radiation intensity of sources with a cartridge...
8476303 N-aminopyrrolylmethyltetrahydropyridines as anti-cancer agents  
The compounds herein disclosed are N-aminopyrrolylmethyltetrahydropyridine analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These...
8476285 Purine-core inhibitors of HSP90 and their use in treating cancer  
The invention relates to compounds of Formulae I-III: and therapeutic uses thereof, wherein A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; B...
8476237 Compositions and methods for treating cancer by inhibiting the secretion of microparticles  
Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and...
8476074 Specific gene polymorphisms in breast cancer diagnosis, prevention and treatment  
A method for detecting a predisposition to breast cancer in a subject is provided. The method includes detecting in a biological sample from the subject one or more polymorphisms in the sequence of...