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9255297 CHK2 polymorphism as a cancer marker  
The invention relates to the use of gene modifications in the human gene CHK2 (CHEK2), which encodes the checkpoint kinase 2, for predicting the risk and progression of cancer diseases, for...
9255155 Antibodies specific for urokinase-type plasminogen activator and methods of treating cancer  
The present disclosure relates to antibodies specific for urokinase-type plasminogen activator (uPA). According to certain embodiments, the anti-uPA antibody specifically binds to the active form...
9255139 Tissue inhibitor of metalloproteinases (TIMP) linked to glycosylphosphatidylinositol (GPI)-anchors for treatment of cancer and skin lesions  
The present invention relates to fusion constructs of glycosylphosphatidylinositol (GPI)-anchored tissue inhibitors of metalloproteinases (TIMPs) and their use for the treatment of cancer and in...
9255116 Multimeric dual-modality breast cancer diagnostic agents  
The present invention describes dual-modality probes. In particular, the present invention discloses hydroxyapatite specific multimeric bisphosphonate dual-modality MRI and optical probes.
9254309 Use of multivalent synthetic ligands of surface nucleolin for treating cancer or inflammation  
A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising...
9254308 Kits and methods for the treatment of cancer using gliadin peptides  
Kits and methods for treating cancer comprising administration of a gliadin peptide to a patient are disclosed herein. A kit according to the invention comprises a pharmaceutical composition...
9254299 Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer  
Cancer can be treated by administration of TH-302 in combination with a Chk1 inhibitor.
9254293 Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH  
This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a...
9254120 Method for predicting breast cancer patient response to combination therapy  
A mass-spectral method is disclosed for determining whether breast cancer patient is likely to benefit from a combination treatment in the form of administration of a targeted anti-cancer drug in...
9250243 Drug selection for lung cancer therapy using antibody-based arrays  
The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of...
9249469 Complex sets of miRNAs as non-invasive biomarkers for colon cancer  
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. Further, the present invention relates...
9249468 Methods and materials related to ovarian cancer  
Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients.
9249467 Bladder cancer detection composition, kit and associated methods  
Compositions, kits, and methods for the diagnosis, prognosis, and monitoring of bladder cancer in a subject are provided by detecting in a urine sample a combination of biomarkers. In one...
9249466 Methods and compositions for treating cancer  
We describe a method of determining whether a cancer cell is likely to be resistant to treatment by an mTOR inhibitor. The method may comprise detecting PPP2R2B (GenBank Accession Number:...
9249409 Method for detection of cancer  
A method for detecting a cancer(s) based on an expression of prescribed polypeptides is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine...
9249223 Humanized anti CXCR4 antibodies for the treatment of cancer  
The present invention relates to a novel isolated humanized antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational...
9249128 Anti-cancer serine hydrolase inhibitory carbamates  
Serine hydrolases are implicated in malconditions such as cancer, central nervous system disorders, cardiovascular disorders, obesity, and metabolic disorders. Many serine hydrolases expressed in...
9248200 Method of delivering an anti-cancer agent to a cell  
There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated...
9248163 Insulin-like growth factor binding protein 7 for treatment of cancer  
Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an IGFBP7 agent...
9248156 Use of extracts or materials extracted from Piper cubeba L. as an effective component in a drug for the treatment of cancer diseases  
The present invention is directed to the use of extracts or of extract compounds from Piper cubeba L. as active components in a medicament for the treatment of cancer. The invention also relates...
9248124 Use of inhibitors of IκB kinase for the treatment of cancer  
The present invention provides inhibitors of IκB kinase of general formula (I). or a stereoisomer or physiologically tolerable salt thereof, for use in the inhibition of the growth of a multiple...
9248114 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ  
The present invention refers to the use of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological...
9248110 Compositions and methods of treating and preventing lung cancer and lymphangioleiomyomatosis  
Compositions and methods for treating and preventing cancer, particularly lung cancer, lymphangioleiomyomatosis and asthma are provided.
9244075 Compositions and methods for detecting, diagnosing, and treating cancer  
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the...
9244058 Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors  
The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for...
9243296 Compositions and methods for prognosis and treatment of prostate cancer  
Described herein are compositions and methods for prognosis and treatment of prostate cancer patients. Specifically the invention relates to microRNA molecules associated with the prognosis of...
9243048 Decreasing cancer cell proliferation with WNT remaining active  
The genes the expression of which is reduced or disappeared in immortal cells including cancer cells are isolated, their DNA sequences are determined, the genes are expressed to produce cell...
9242041 Method and apparatus for cancer treatment  
An apparatus for treating solid tumors having at least one hollow needle having at least one perforation, at least one ground electrode, a pump for delivering a chemotherapeutic agent through the...
9242012 Methods for killing PSMA-expressing, taxane-resistant cancer cells  
Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted...
9241998 Methods and compositions for treatment of cancer using oncolytic RSV activity  
The present invention relates generally to methods and compositions employing the oncolytic activity of respiratory syncytial virus (RSV) to treat cancer and other neoplastic disorders.
9241949 Compositions and methods for treating cancer  
A method of one or more of, inhibiting motility, migration, dispersal, and metastasis of a cell that expresses an RPTP, which is proteolytically cleaved to form intracellular fragments in the cell...
9241920 Inhibition of c-Myc ubiquitination to prevent cancer initiation and progression  
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of Fbw7 E3 ligase inhibitors to...
9238682 Anti-cancer therapeutic strategy to overcome cancer resistance and to enable tailoring treatment to patients  
A gene construct comprising a programmed-cell-death executioner gene having a nuclear localization signal, a deleted signal peptide, an inhibitor-resistant binding site, a promoter, and an...
9238677 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders  
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
9238659 Method of using binuclear gold (I) compounds for cancer treatment  
Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as...
9238645 ITE for cancer intervention and eradication  
A method of cancer intervention or eradication by administering an effective amount of an endogenous ligand for the aryl hydrocarbon (Ah) receptor (AhR) named ITE or one of its analogs (the active...
9238084 Anti-mucin antibodies for early detection and treatment of pancreatic cancer  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The antibodies show...
9238069 Method of sensitizing cancer cells to the cytotoxic effects of death receptor ligands in cancer treatment  
Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor...
9238064 Allogeneic cancer cell-based immunotherapy  
Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g.,...
9238040 Chemoprevention of colorectal cancer by mesalamine/sulfasalazine  
A method for preventing colorectal cancer in a patient possessing human tropomyocin isoform TC22 is disclosed. The method comprises: (a) detecting a serum protein concentration of TC22 in a...
9238022 Xanthanodien for the treatment of cancer  
The present invention relates to a method for the treatment or prophylaxis of a disease associated with hyperproliferative cellular division, comprising administering to a subject in need thereof...
9234893 Marker comprising anti-CK8/18 complex autoantibody and its use for diagnosing cancer  
The present invention relates to a cytokeratin 8/18 complex-specific autoantibody or a fragment comprising an antigen-binding site (paratope) thereof, the use thereof in the diagnosis of breast...
9234245 Prognostic signature for colorectal cancer recurrence  
An assay system is useful for predicting recurrence and/or non-recurrence of colorectal cancer in a patient. The assay system is adapted to analyze a patient sample for quantitative expression of...
9234185 Chimeric adenoviruses for use in cancer treatment  
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
9234183 Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of its capsid  
Described is a parvovirus, in particular a H-IPV, that can be genetically retargeted through modification of its capsid, which is useful in cancer therapy.
9234002 Small peptide specific for lung cancer and application thereof  
A peptide including 8 animo acids having a sequence of cNGEGQQc, where c represents d-cysteine (Cys), N represents L-Asparagine (Asn), G represents L-Glycine (Gly), E represents L-Glutamic acid...
9233144 Tyrosine kinase receptor TYRO3 as a therapeutic target in the treatment of cancer  
The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.
9233139 Method of treating cancer with a composition containing a C12ORF59 protein  
As explained hereinbefore, the C12orf59 gene of the present invention suppresses cancer cell invasion and inhibits cancer cell survivability, and the over-expression of C12orf59 protein or a...
9233132 Lung cancer therapy using an engineered respiratory syncytial virus  
The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat lung cancer by killing cancer cells with in vitro and in vivo...
9233125 Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer  
The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which provides T cells with the ability and specificity to recognize and kill target...