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9051562 Polypeptides isolated from brevibacterium aurantiacum and their use for the treatment of cancer  
The present invention relates to methods and pharmaceutical compositions for treating cancer. More specifically, the invention relates to a polypeptide isolated from Brevibacterium aurantiacum...
9051385 Compositions employing alternative reading frame polypeptides for the treatment of cancer and infectious disease  
Provided are alternative reading frame (ARF) polypeptides as well as antigen presenting cell (APC) and dendritic cell (DC) based compositions that comprise ARF polypeptides. ARF polypeptides and...
9051377 Method for treating breast cancer using antibody binding to MMP-14  
Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
9051372 Anti-CD70 antibody and its use for the treatment of cancer and immune disorders  
Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as...
9051348 Ginsenoside with anti-cancer activity and the preparation method thereof  
The present invention relates to a novel compound derived from ginsenoside Rh2, the preparation methods and the use thereof in treating cancers.
9051271 Substituted pyridine derivatives useful in the treatment of cancer  
The present invention describes compounds of formula (I) Wherein: R1 is selected from C1-C6 alkyl, CF3, Phenyl & 2-thienylR2 is selected from C1-C6 alkyl, phenyl & CF3 R3 is selected from H, C1-C6...
9050340 Compositions of engineered human arginases and methods for treating cancer  
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate...
9046589 Dynamic MR imaging of patients with breast cancer—establishment and comparison of different analytical methods for tissue perfusion and capillary permeability  
The present invention encompasses methods, apparatus, and computer based systems for identifying benign and malignant tumors in tissues such as soft tissues and particularly breast tissue using...
9046522 Markers for endometrial cancer  
The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183,...
9046521 Cancer evaluation method using haptoglobin β chain defined by antibody RM2  
The object of the present invention is to identify a molecule that is specifically recognized by antibody RM2 in tissue or serum of a cancer patient, and provide a method for diagnosing cancer in...
9045802 Method and probe set for detecting cancer  
Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected...
9045756 Compositions and methods for treating cancer and other diseases  
Aptamers and improved aptamers are provided with enhanced efficacy for binding to target molecules in vivo or for treating cancer or other diseases. Such improvements in aptamers are provided that...
9045556 Therapeutic agent for cancer  
The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also...
9045545 Precision medicine by targeting PD-L1 variants for treatment of cancer  
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
9045475 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9045450 Method for chemical synthesis of antrocin and use thereof for suppressing non-small cell lung cancer  
The present invention provides a method for preparing antrocin of pharmaceutically acceptable salts thereof via a series of gold-catalyzed cyclization to construct the (6-6-5) tricyclic core...
9045420 Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed...
9044506 MIR-21 promoter driven targeted cancer therapy  
The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of...
9044474 Compositions and methods for increasing drug efficacy in cancer  
A method of (a) treating a lymphoproliferative disease in a subject in need thereof; (b) slowing the progression of lymphoproliferative disease in a subject who has been diagnosed with a...
9044467 Methods for assisting anti-cancer drugs  
A method for assisting an anti-cancer drug comprising administrating an effective amount of Antrodia camphorata fermentation solution to improve life quality of patient suffering from cancers...
9044464 No-releasing guanidine-coxib anti-cancer agents  
The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, R11, Z and L are as defined in the detailed description;...
9044461 Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency  
The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention...
9044432 Compositions and methods for cancer detection and treatment  
Disclosed herein are compositions and methods for cancer detection and treatment. Compounds that inhibit PRMT5 are contemplated, as are pharmaceutical compositions comprising a therapeutically...
9040671 Methods for cancer management targeting Co-029  
The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer...
9040574 Method of treating androgen independent prostate cancer  
The present invention is directed to a method treating prostate cancer. The method comprises administering to a patient in need thereof at least one compound selected from...
9040505 Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis  
Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that...
9040501 Compositions and methods for treating cancer  
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
9040497 Treatment and diagnosis of colon cancer  
The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.
9040286 Diagnosis and treatment of cancer  
Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an...
9040100 Methods for inhibiting prostate cancer by kinases and angiogenesis inhibitory mechanisms of ball moss extract  
A method of treating prostate cancer by administering a pharmaceutically-acceptable amount of a crude extract of the indigenous Jamaican plant Ball Moss (Tillandsia Recurvata) comprising one or...
9040081 Use of lipid containing particles comprising Quillaja saponins for the treatment of cancer  
The present invention relates to the use of lipid containing particles, such as liposomes, iscom and/or iscom matrix and posintros, comprising at least one lipid and at least one saponin for the...
9040047 Combinations of anti ErbB antibodies for the treatment of cancer  
An article-of-manufacture is provided. The article-of-manufacture comprises a packaging material identified for treating cancer, packaging: (i) an anti-EGFR antibody comprising the CDR sequences...
9040044 Compositions and methods for treating and diagnosing cancer  
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
9035036 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments  
Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will...
9034875 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9034862 Compositions and methods for the treatment of cancer  
The present invention relates to compositions, kits, and methods for treatment of cancers. In some cases, the composition comprises a platinum compound comprising a phenanthridine ligand.
9034854 Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy  
The present invention relates to a method of treating or preventing estrogen-sensitive tumors in a mammal, said method comprising the administration of a therapeutically effective amount of an...
9034828 Syndecan peptides and polypeptides as inhibitors of cancer  
The invention provides for peptides from syndecan 4 and methods of use therefor. These peptides can inhibit α6β4 integrin interaction with EGFR, thereby preventing tumor cell growth and tissue...
9034827 Syndecan peptides and polypeptides as inhibitors of cancer  
The invention provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit α4β6 interaction with HER2, thereby preventing tumor cell growth and tissue invasion.
9034588 Monoclonal antibody therapy for pancreas cancer  
The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively...
9034587 Methods of diagnosing cancer  
A method of diagnosing cancer or a pre-malignant lesion is disclosed. The method comprises determining a level of CD24 expressed on peripheral blood cells of a subject in need thereof, wherein the...
9034344 Chimeric adenoviruses for use in cancer treatment  
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
9034319 Methods of treating cancer of the central nervous system  
A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an...
9034312 Extracellular matrix compositions for the treatment of cancer  
The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are...
9034310 Interferon-statin combination cancer therapy  
A method for pharmacological treatment of cancers and other diseases is presented which includes the novel combination of a statin (Hmg-CoA reductase inhibitor, such as lovastatin, simvastatin,...
9032964 Method and system for processing cancer cell electrical signals for medical therapy  
A scientific computer system with processor capable of recording, storing, and reprogramming the natural electrical signals of cancer cells as found in tumors of humans and animals. The...
9029408 Compounds for treatment of cancer  
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a...
9029404 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
9029403 Treatment of ovarian cancer with benzylidenebenzohydrazides  
Methods for inhibiting the growth of ovarian cancer cells or other serosal cancer cells are disclosed. The method involves exposing the cells to a benzylidinebenzohydrazide of formula: wherein X...
9029340 Radiation sensitization agents for prostate cancer  
Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of...