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9393268 Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same  
Isolated pluralities of T cells which recognize at least one epitope of an intestinal cancer antigen or CNS cancer antigen and pharmaceutical compositions comprising the same are disclosed....
9393234 Pharmaceutical compositions and methods for treating cancer and biomarkers for drug screening  
A pharmaceutical composition comprising sorafenib and GW5074. Said combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction pathway in either in vitro or in...
9392960 Focused prostate cancer treatment system and method  
Systems and methods for locating lesions in a prostate or other organ during a first intervention session, and for using that lesion location information during a second intervention session are...
9389235 Methods of using biomarkers for predicting the outcome of an immunotherapy against cancer  
The present invention relates to methods for predicting the effect of an immunotherapy against cancer in a patient based on new biomarkers. The present invention furthermore relates to a prognosis...
9389220 In vitro assay systems and methods for identifying anti-cancer agents  
The present disclosure relates generally to drug discovery and development and, more particularly, to in vitro assay systems and methods for selecting lead anti-cancer agents for subsequent...
9388471 Methylation of the GATA4 gene in urine samples as a marker for bladder cancer detection  
A method of detecting a predisposition to, or the incidence of, bladder cancer in a sample comprises detecting an epigenetic change in at least one gene selected from FOXE1 and GATA4. Detection of...
9388470 Serum or plasma microRNA as biomarkers for non-small cell lung cancer  
The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of...
9388404 Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer  
A method for the in vitro diagnosis of colorectal cancer that comprises determining the presence of the protein disulfide isomerase tumor marker in a biological sample taken from a patient...
9388248 Anti-CXCR4 antibodies and their use for the treatment of cancer  
The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the...
9388247 Antibodies against cancer target block tumor growth, angiogenesis and metastatis  
The present invention provides antibodies that target the first-third domains of N-cadherein and the fourth domain of N-cadherin, for diagnosis and therapy of cancers related to N-cadherein....
9388216 Methods of treating reproductive cancer  
The present invention relates to agents, compositions and methods for use in medicine. In particular, the invention relates to agents related to GnRH peptides.
9388155 Coumarin derivatives for cancer therapy  
The disclosure provides methods and compositions for treating and preventing cancer using 6-substituted coumarin derivatives. The coumarin derivatives of the disclosure have substituents at the...
9387257 Lung cancer specific peptides for targeted drug delivery and molecular imaging  
A conjugate is disclosed. The conjugate comprises (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least...
9387230 Methods to treat cancer using cyclosporine and cyclosporine derivatives  
Methods to treat certain types of cancer with cyclophilin inhibitors.
9387221 SDF-1 binding nucleic acids and the use thereof in cancer treatment  
The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid molecule is for use in a method for the...
9387202 Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities  
Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Pharmaceutical compositions and methods of treatment employing the...
9387192 Combination of rocaglamide and apoptosis inducing substances for the treatment of cancer  
The present invention relates to a combined preparation comprising at least one rocaglamide derivative and at least one apoptosis inducing agent, preferably from the group of substances comprising...
9382590 Methods and compositions for prostate cancer metastasis  
Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.
9382589 Individualized cancer therapy  
In certain preferred embodiments, the invention provides methods for treating cancer, which comprise (a) obtaining a specimen of cancer tissue from a patient; (b) obtaining a specimen of normal...
9382588 Markers for identifying breast cancer treatment modalities  
The present invention includes methods for identifying patients who will be resistant to endocrine therapy during breast cancer treatment and determining patient outcome. The methods are based on...
9382587 Diagnosis of breast cancer based on expression level of thioredoxin-1  
The present disclosure relates to a diagnostic marker for breast cancer, having thioredoxin-1 as an active ingredient, and to a diagnostic kit for breast cancer using the same. The thioredoxin-1...
9382525 Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents  
The present invention provides a site-specific pegylated arginase conjugate and method for producing thereof. The site-specific pegylated arginase is homogeneous in molecular weight and shows...
9382376 Use of polymer D-lactic acid (PDLA) or equivalents thereof to inhibit growth of cancer cells and diagnose cancers  
The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or...
9382331 Alpha-enolase specific antibodies and methods of uses in cancer therapy  
The present invention discloses an anti-human alpha-enolase (ENO1) antibody, which can bind the peptides, comprising amino-acid sequence 296FD Q D D W G A W Q K F TA309 (SEQ ID: #9) and/or 326K R...
9382228 N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities  
Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR...
9382202 Precursor for labeling therapeutic agent for liver cancer and method for manufacturing the same  
A precursor for labeling therapeutic agents for liver cancer and a method for manufacturing the same are revealed. The chemical structure of the precursor has a ligand linked to complex compounds...
9381246 Cancer therapy  
The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic...
9381244 VISTA modulators for diagnosis and treatment of cancer  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
9381184 Compounds and compositions for targeting cancer stem cells  
The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds,...
9380959 MRI-guided nanoparticle cancer therapy apparatus and methodology  
An apparatus and method direct nanoparticles in a body part under imaging guidance using at least one electromagnet configured and operable to create a magnetic field gradient used to direct the...
9377474 Prodefensin-A6 assay method for the in vitro diagnosis of colorectal cancer  
The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumor marker in a biological sample taken from a patient...
9377463 Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith  
The invention relates to a method for the determination of a cancer diagnostic/therapeutic biomarker assay and drug-targets including the following steps: (a) identification of potential candidate...
9376720 Method to assess prognosis and to predict therapeutic success in cancer by determining hormone receptor expression levels  
The present invention is related to a method of classifying a sample of a patient who suffers from or being at risk of developing cancer, said method comprising the steps of determining in said...
9376497 Compositions and methods for diagnosing and treating cancer  
An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of...
9376492 Treatment of cancer  
The present invention relates to agents for use in treating cancer. The agent to be used is an antagonist of Dsg2, wherein the antagonist modulates the function of the amino acid sequence:...
9376475 Gene overexpressed in cancer  
Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding...
9376473 Use of Toll-Like Receptor agonist for treating cancer  
The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present...
9376425 Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer  
The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as...
9376406 uPAR-uPA interaction inhibitors and methods for treating cancer  
The invention described herein pertains to compounds, compositions and formulations comprising the compounds, and methods for use of the compounds, compositions and/or formulations in the...
9375496 Halogenated compounds for cancer imaging and treatment and methods for their use  
Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein...
9375475 Combination immunotherapy for the treatment of cancer  
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the treatment of tumors.
9375474 Compounds useful for inhibiting metastasis from cancer and methods using same  
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or...
9375448 Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties  
The invention relates to the use of encapsulates of cancer cells, in agarose coated, agarose containing beads, for isolating chemotherapeutic resistant cells which have at least one stem cell...
9375447 Modified hyaluronan and uses thereof in cancer treatment  
Uses of depolymerized hyaluronan (e.g., prepared by sonicating high molecular weight hyaluronan such as naturally-occurring hyaluronan) or anti-Hyal-2 antibody in cancer treatment. Also described...
9375443 Method for treating advanced non-small cell lung cancer (NSCLC) by administering a combination of a TOR kinase inhibitor and azacitidine or erlotinib  
Provided herein are methods for treating or preventing advanced non-small cell lung cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of...
9375425 Combination of a C-Met antagonist and an aminoheteroaryl compound for the treatment of cancer  
The invention also relates to a composition comprising an antibody antagonist to c-Met and an aminoheteroaryl compound, particularly as a medicament. The present invention also comprises a...
9372136 Agent for improving cancer cell adhesiveness  
A polymer comprising a constitutional unit represented by the following formula (1) is useful because when the polymer is applied to a surface of a cancer cell enrichment filter, adhesiveness of...
9371569 Detection and prognosis of cervical cancer  
The present invention relates to methods and kits for identifying, diagnosing, prognosing, and monitoring cervical cancer. These methods include determining the methylation status or the...
9371380 Antitumor agent and therapeutic effect prediction method for patients with KRAS-mutated colorectal cancer  
This invention provides a method for predicting a therapeutic effect of chemotherapy that uses an antitumor agent comprising α,α,α-trifluorothymidine and...
9371362 Prostate specific antigen agents and methods of using same for prostate cancer imaging  
The invention provides a family of agents that target the prostate specific antigen, which can be used as imaging agents or therapeutic agents. The agents can be used to image prostate cancer as...