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8710091 Imidazolidine-2,4-dione derivatives, and use thereof as a cancer drug  
The present application relates to novel imidazolidine-2,4-dione derivatives of the general formula (I), where R1, R2, R3, R4, X, and Y are variables. Said materials have an antiproliferative...
8710068 Method of treating cancer using a survivin inhibitor  
Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a...
8710035 Methods and compositions related to glucocorticoid receptor antagonists and breast cancer  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other...
8710020 Clusterin antisense therapy for treatment of cancer  
A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefits in the treatment of cancer comprising administering from 40 to 640 mg...
8709981 Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development  
The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are...
8709732 Biomarkers of gastric cancer and use thereof  
A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression of...
8709731 DKK1 oncogene as therapeutic target for cancer and a diagnosing marker  
Described herein are antibodies and antibody fragments capable of treating or preventing cancers associated with the over-expression and/or up-regulation of DKK1. Also disclosed are methods of...
8709719 ZNF217 a new prognostic and predictive biomarker of recurrent invasive and metastatic phenotypes in breast cancer  
The present invention relates to methods for determining the prognosis of a cancer. The methods involve determining the level of expression of the ZNF217 gene in a cancer cell sample or in a tumor...
8709718 Method of treating lung cancer  
A method of predicting a lung cancer patient's response to FGFR inhibitors is disclosed herein, particularly in patients with squamous cell lung cancer.
8709474 Liposomes with improved drug retention for treatment of cancer  
The present invention relates to the use of copper ions to achieve enhanced retention of a therapeutic agent within a liposome. The invention may be employed to more effectively deliver a...
8709432 Methods for increasing efficacy of FOLR1 cancer therapy  
Methods to improve the success of cancer therapies that target the human folate receptor 1 are provided. Kits comprising reagent useful in the methods are further provided.
8709430 Cancer treatment kits comprising therapeutic antibody conjugates that bind to aminophospholipids  
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor...
8709418 Pharmaceutical composition for treating CAPRIN-1 expressing cancer  
According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen...
8709417 Combination immunotherapy for the treatment of cancer  
Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.
8709405 Cancer vaccines containing epitopes of oncofetal antigen  
Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions...
8709404 Immunotherapy in cancer treatment  
The present invention relates to a novel method of cancer immuno-therapy and to a kit for use in this method. Specifically, the present invention relates to a novel method of collecting lymphocytes...
8706258 Method and apparatus for treating cancer  
A method and apparatus for treating masses, such as prostate or breast cancer, or any other soft tissue cancerous or benign mass, employs a unique, three-dimensional software-controlled electronic...
8703961 Thiazole derivatives for the treatment of diseases such as cancer  
Compounds of the formula Ia and Ib, in which R1, R1′, R2, R3, R5, R6 and R7 have the meanings indicated in claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.
8703930 Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associated genes  
The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation....
8703808 Use of derivatives of indoles for the treatment of cancer  
The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.
8703756 Synthetic procedure and cancer treatment with cisplatin derivatives  
A method of reducing the in vivo viability of cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells has steps...
8703736 Therapeutic target for pancreatic cancer cells  
This invention provides a therapeutic target for pancreatic cancer. The invention further provides methods of screening of new therapeutic agents using the target. The invention also provides a...
8703715 Methods for inhibiting growth of prolactin-responsive cancer cells with cyclosporine a or other cyclophilin inhibitors  
Methods are provided for inhibiting growth of prolactin-responsive cancer cells and treating prolactin-responsive malignancies via administration of an agent such as cyclosporine A which directly...
8703713 Combination therapy for pancreatic cancer using an antigenic peptide and chemotherapeutic agent  
Described herein is a combination therapy suited to the treatment of pancreatic cancer and the like. Also described is a method of potentiating the therapeutic effect of chemotherapeutic agents...
8703712 Targeting cancer stem cells with DR5 agonists  
Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more...
8703425 Biomarker for gastric cancer  
The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the BCL6B gene, which in some cases is due to...
8703211 Agent and method for treating cancer comprising strontium, amino acid(s) and mineral agent(s)  
The invention relates to the treatment and prophylaxis of cancer. In particular, the invention relates to a pharmaceutical agent comprising strontium, amino acid(s) and mineral element(s), and its...
8703120 Use of oncolytic herpes viruses for killing cancer stem cells  
The invention, in some aspects, relates to the selective killing of cancer stem cells by oncolytic Herpes virus mediated oncolysis. In some aspects, the invention relates to methods for treating a...
8697855 Anti-CD151 antibodies and their use in the treatment of cancer  
The present invention relates to new antibodies capable of binding specifically to the human CD151 protein, especially monoclonal antibodies of murine origin, which are chimeric and humanized, and...
8697668 Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG215 and/or UBP43  
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer...
8697666 Anti-cancer oligodeoxynucleotides  
It is disclosed herein that suppressive OD Ns are of use for preventing or delaying the formation of a tumor, reducing the risk of developing a tumor, treating a tumor, preventing conversion of a...
8697373 Reagents and methods for use in cancer diagnosis, classification and therapy  
Methods and reagents for classifying HER2+ breast tumors and for identifying new HER2+ breast tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen...
8697368 Diagnostic marker for lung cancer comprising HPαR as active ingredient  
Disclosed is a diagnostic marker for lung cancer comprising HpαR as an active ingredient. Because blood, which is relatively easy to sample, is employed as a specimen, the diagnostic kit and ...
8697366 Anti-cancer drug screening method using RORα  
The present invention relates to a method for screening an anticancer agent using RORα, the method comprising the steps of: culturing cells; bringing a potential substance into contact with the ...
8697360 Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition  
It has been discovered that certain polymorphic markers on chromosome 6 and chromosome 11 are indicative of a susceptibility to prostate cancer and colon cancer. The invention describes diagnostic...
8697358 Non-invasive method for diagnosis of prostate cancer  
The present invention relates on a non-invasive method for diagnosing prostate cancer and/or assessing the risk of a subject acquiring prostate cancer comprising the analysis of the expression of...
8697350 Biomarker combinations for colorectal cancer  
The present invention relates to methods and kits for the detection of predetermined biomarkers for early diagnosis and management of cancer, and in particular, colorectal cancer.
8697181 Multifunctional Fe3O4 cored magnetic-quantum dot fluorescent nanocomposites for RF nano-hyperthermia of cancer cells  
A magnetic oxide-quantum dot nanocomposite and methods of synthesizing it. In one embodiment, the magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a...
8697079 IgE antibodies for the treatment of cancer  
The present invention provides monoclonal IgE antibodies comprising Fc epsilon (ε) constant regions and variable regions comprising at least one antigen binding region specific for binding a ...
8697075 Cancer specific antibody and cell surface proteins  
The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the invention...
8697072 Targeting ABCB5 for cancer therapy  
The invention related to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules...
8691870 Use of isothiocyanates for treating cancer  
Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead...
8691851 Lanthanide metal complexes useful in treating cancer  
The present invention relates to a compound of formula (I). Provided is also a method of killing a cell that comprises administering the compound of formula (I). Provided is also a method of...
8691819 Alpha helix mimetic compositions for treating cancer and other CBP/catenin-mediated diseases and conditions  
Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating...
8691801 Use of manzamine compounds in anti-cancer therapeutic regimens  
Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to...
8691799 Materials and methods for treatment of cancer and identification of anti-cancer compounds  
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular...
8691232 Extending time to disease progression or survival in cancer patients  
The present application describes extending time to disease progression or survival in a cancer patient, where the patient's cancer displays HER activation, by treating the patient with a HER...
8691229 Method of PLSCR inhibition for cancer therapy  
The present invention relates to a method of using inhibitors of phospholipid scramblases (PLSCRs) for the prophylactic or therapeutic treatment of cancers. The PLSCR-inhibitors of the invention...
8691212 Therapeutic/prophylactic agent for prostate cancer  
Provided are a novel therapeutic agent and therapeutic method for prostatic cancers. More specifically, a prostatic cancer therapeutic/prophylactic agent having a viral envelope vector,...
8691189 Method of colorectal cancer detection by using radiolabeled anti-GRP78 peptide  
The present disclosure describes techniques used for colorectal cancer detection. Position and distribution of colorectal cancer tumor are detected through nuclear imaging. Alternatively, stage of...