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8592173 Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity  
Methods for cancer diagnosis, making decisions on appropriate cancer treatment, awareness of a predisposition to cancer and potential cancer prevention, and monitoring of cancer therapy by...
8592168 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
8592152 Gene detection assay for improving the likelihood of an effective response to an EGFR antagonist cancer therapy  
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene amplification assay, with an EGFR...
8592147 High-content screening for drugs against cancer and age-related diseases  
The invention relates to methods for high-throughput screening for compounds that modulate cell growth or promoter activity. The invention provides the use of cell lines with properly regulated...
8592145 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Cancer marker, method for evaluation of cancer by using the cancer marker, and evaluation reagent
 
The present invention provides a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject, and an evaluation method using...
8591921 Induction of tumor hypoxia for cancer therapy  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
8591892 FTY720 increases CD74 expression and sensitizes cancer cells to anti-CD74 antibody-mediated cell death  
Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in...
8591887 EPHA2 as a therapeutic target for cancer  
The present invention is directed to compounds and methods for the treatment of metastatic disease. The compounds of this invention have specificity for EphA2, an epithelial cell tyrosine kinase...
8591863 Compositions against cancer antigen LIV-1 and uses thereof  
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
8586754 BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed...
8586749 Compounds that suppress cancer cells and exhibit antitumor activity  
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs,...
8586557 Therapy of p53 mutant colon adenocarcinoma, breast cancer and lung cancer  
The present invention provides a method for treating a hyperproliferative disorder characterized by expression of a mutant form of p53 in a subject, the method comprising administering to the...
8586553 Therapies for cancer using RLIP76  
The present invention is a composition identified as a region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1, reduces transport...
8586544 Cell-permeable endostatin recombinant protein, a polynucleotide encoding the same, and an anti-cancer preparation containing the same as an active component  
The present invention relates to a cell-permeable endostatin recombinant protein in which a macromolecule transduction domain (MTD) is fused to an angiogenesis inhibitor (angiogenesis inhibitor)...
8586543 IL-8 biomarker for monitoring cancer treatment with certain ERK inhibitors  
The present application includes methods for using IL-8 as a biomarker for, e.g., tumor size, for example, during course of treatment with an anti-cancer agent such as an ERK inhibitor.
8586380 Monitoring treatment of head and neck cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples  
Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or...
8586379 Monitoring treatment of colorectal cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples  
Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or...
8586313 DNA methylation markers based on epigenetic stem cell signatures in cancer  
In particular aspects, stem-cell polycomb group (PcG) targets are more likely to have cancer-specific promoter DNA methylation than non-targets, indicating a stem-cell origin of cancer, where...
8586050 Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy  
Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than...
8586043 Methods for treating breast cancer with inhibitors of neurotensin activation of NTSR1  
The present invention relates to methods for the treatment, the prognostic assessment and the detection of breast cancer.
8583588 Method for judging risk of cancer recurrence, computer program, and computer system  
A method for judging a risk of cancer recurrence comprising: acquiring an activity value and expression level of a first cyclin dependent kinase (CDK) of a cell contained in tissues extracted from...
8583380 Methods for stratifying and annotating cancer drug treatment options  
Personalized medicine involves the use of a patient's molecular markers to guide treatment regimens for the patient. The scientific literature provides multiple examples of correlations between...
8583216 Skin type assessment and nevi screening for skin cancer with a noninvasive, portable reflectance spectrophotometer  
The invention relates to a method for objectively measuring skin phototype by reflectance spectrophotometry. The improved method correlates well with clinician-based assessments and is...
8581215 Charged particle cancer therapy patient positioning method and apparatus  
The invention comprises a patient positioning method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The patient positioning...
8580975 Synthesis of macrocyclic cancer chemotherapy agents and methods of use  
Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in...
8580847 Antrocin containing pharmaceutical compositions for inhibiting cancer cells  
This subject invention is directed to a method for inhibition of cancer cells, comprising administrating an effective amount of a compound of formula I (Sesquiterpene lactones, antrocin) or...
8580814 Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer  
Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure...
8580798 Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders  
Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein...
8580794 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
8580792 Inhibitor compounds and cancer treatment methods  
A synergistically effective combination of an anti-cancer agent and a therapeutic compound, such as an mTOR-Rictor complex inhibitor, a Serine 473 phosphorylation inhibitor, an AKT2 inhibitor, or a...
8580764 Combinational compositions and methods for treatment of cancer  
The present invention provides methods of treating a cell proliferative disorder, such as lung cancer and breast cancer, by administering to a subject in need thereof a therapeutically effective...
8580758 Method of inhibiting cancer cell proliferation, proliferation inhibitor and screening method  
The present invention provides a method of inhibiting cancer cell proliferation by suppressing a function of ZNF143, a cancer cell proliferation inhibitor containing as an active ingredient a...
8580753 Modulation of telomere length in telomerase positive cells and cancer therapy  
Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention...
8580509 Recurrent gene fusions in prostate cancer  
Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and...
8580501 Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment  
The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or...
8580500 Methods for diagnosing lung cancer using microRNAs  
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
8580498 Predictive value of nuclear excision repair genes for cancer survival  
Patients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene...
8580491 Cancer diagnosis marker using the aberrant glycosylation of a protein  
The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein. More precisely, the present invention relates to a cancer...
RE44596 Method for the detection of cancer  
The present invention relates to a method for the diagnosis and/or the follow up of the evolution of cancer, which includes the analysis and quantification of over expressed and amplified genes in...
8575308 Method for cancer immunotherapy  
A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group or...
8575191 Methods for treatment of non-small cell lung cancer  
The present invention provides methods of treating non-small cell lung cancer by administering to a subject in need thereof a therapeutically effective amount of a...
8575170 Flurbiprofen analogs and methods of use in treating cancer  
Flurbiprofen analog compounds having an amino acid derivatized at the flurbiprofen alkanoic acid carboxyl group and terminating at an ester or amide group are effective in inhibiting cancer cells...
8575164 Combination cancer therapy  
Methods and compositions for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially (a) a therapeutically effective amount of an...
8575141 Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer  
The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for...
8575124 Compositions and methods for treating cancer  
This invention generally relates to compositions and methods for targeted delivery of chemotherapeutic agents to cancerous and pre-cancerous cells, thereby treating a cancer in a subject.
8575121 Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer  
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the...
8574854 Anti-mucin antibodies for early detection and treatment of pancreatic cancer  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The antibodies show...
8574829 Methods of treating cancer with phenformin  
Methods of using phenformin to treat certain types of cancers are described.
8569382 Isolated compounds from Phaleria macrocarpa as anti-cancer agents  
The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said...
8569348 Compounds, compositions, and methods for preventing metastasis of cancer cells  
Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.