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8211643 |
Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy
The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way...
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8211635 |
P53 modulator and cancer target
Methods of screening for modulators of TRIM24 (also known as TIF1-ALPHA) expression and/or biological activity are described. In particular, methods of screening of screening for modulators of...
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8211634 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding...
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8211630 |
Diagnostic agent and therapeutic agent for pancreatic cancer
The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for...
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8211425 |
Method for treating disseminated cancer
The present invention discloses an immunotherapeutic method for treating a patient suffering from a disseminated cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+...
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8211402 |
CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer
A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus,...
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8208142 |
Lung cancer detection by optical analysis of body fluids
The method for lung cancer detection by optical analysis of body fluids relates to analyzing samples of blood, urine and sputum by fluorescence spectroscopy in order to detect the presence of...
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8207325 |
MicroRNA biomarkers for human breast and lung cancer
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
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8207314 |
Tumor antigens for prevention and/or treatment of cancer
The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. In particular, the invention relates to...
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8207300 |
CTSP cancer-testis antigens
The invention relates to CTSP polypeptides and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments...
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8207295 |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
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8207206 |
(S,R)-3-phenyl-4,5 dihydro-5-isoxazole acetic acid-nitric oxide and use thereof as anti-cancer and antiviral agent
The present invention relates to an isoxazole derivative, the compound of formula (I) herein after referred to as GIT27-NO, which is the NO-donating structurally modified form of...
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8207166 |
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
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8207152 |
Methods for treating or preventing cancer by preventing, inhibiting, or arresting cell cycling
There is provided use of a cyclic compound or a pharmaceutically active salt thereof in the manufacture of a medicament to prevent and/or inhibit and/or arrest cell cycling, wherein the cyclic...
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8207143 |
Methods of treating cancer and other conditions or disease states using LFMAU and LDT
The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease...
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8207130 |
Combination cancer immunotherapy with co-stimulatory molecules
Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective...
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8207128 |
Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof
Described is a polypeptide inhibiting the transmigration of leukocytes or the growth and/or metastasis of cancer cells, a fusion protein thereof, a polynucleotide encoding the polypeptide, a vector...
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8207122 |
Anti-cancer bioactive peptides isolated from crude venom of Xinjiang Lycosa singoriensis
An anti-cancer bioactive peptide having an amino acid sequence as shown in SEQ ID NO.1, or a functional analogue thereof prepared by substitution, insertion, or deletion of one or more amino acids...
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8206934 |
Methods for diagnosing ovarian cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention...
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8206919 |
Gene expression markers for breast cancer prognosis
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
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8206910 |
Targets for use in diagnosis, prognosis and therapy of breast cancer
The invention is directed to methods of diagnosing breast cancer, susceptibility to breast cancer, nodal metastasis of a breast cancer and screening for breast cancer in an individual in need...
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8206899 |
Prostate cancer-related compositions, methods and kits based on DNA microarray proteomics platforms
The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including,...
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8206713 |
Method of treating cancer using antibodies to a non-ligand binding region of NOTCH2
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
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8206702 |
Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with cancer
The present invention discloses an improved method for expansion and activation of tumor-reactive lymphocytes, in particular CD4+ helper and/or CD8+ T-lymphocytes, which may be used for treating...
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8202968 |
Predicting lung cancer survival using gene expression
The present invention provides a plurality of biomarkers for predicting survival of a subject with a lung cancer. More specifically, the present invention relates to methods of predicting survival...
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8202881 |
JAK2 inhibitors and their use for the treatment of myeloproliferative diseases and cancer
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK2, thereby making them useful as...
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8202866 |
Ortho-aminoanilides for the treatment of cancer
The present invention is directed to a compound of formula I, and processes for the manufacture of said compounds as well as medicaments containing said compound. The compounds according to this...
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8202849 |
Methods and compositions for the inhibition of Stat5 in prostate cancer cells
The present invention relates to compositions and methods for the treatment of prostate cancer. In certain embodiments, the invention relates to compositions and methods for the inhibition of...
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8202692 |
Expression profile of thyroid cancer
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression...
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8202690 |
Cancer marker and therapeutic agent for cancer
A novel cancer marker is provided. A method for detecting cancer using a level of BMCC1 gene expression as an indication is provided, in which the cancer is selected from the group consisting of...
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8198607 |
Tandem accelerator method and apparatus used in conjunction with a charged particle cancer therapy system
The invention comprises a tandem accelerator method and apparatus, which is part of an ion beam injection system used in conjunction with multi-axis charged particle radiation therapy of cancerous...
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8198413 |
Anti-CD151 antibodies and their use in the treatment of cancer
The present invention relates to new antibodies capable of binding specifically to the human CD151 protein, especially monoclonal antibodies of murine origin, which are chimeric and humanised, and...
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8198411 |
Anti-mullerian inhibiting substance type II receptor (MISIIR) immunoconjugates to detect and treat cancer
Compositions and methods for detecting and treating cancers expressing Mullerian inhibiting substance Type II receptor (MISIIR) are provided.
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8198328 |
Treatment of cancer using benzoic acid derivatives
The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are...
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8198292 |
Vinpocetine and eburnamonine derivatives for promoting bone growth, treating renal damage and cancer, and devices thereof
The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The...
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8198264 |
Method for treating head and neck cancer
The present invention is directed to a method for the treatment of advanced head and neck cancer, the method including administering, in combination, S-1 and cisplatin and concurrently performing...
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8198254 |
Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer
Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating...
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8198236 |
Methods and compositions for the treatment of cancer
Oligopeptides which can be used to treat cancer are disclosed. Further disclosed are methods of treating cancer, including breast cancer, skin cancer, prostate cancer and multiple myeloma (MM)....
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8198038 |
Plasma biomarker tool for the diagnosis of liver cancer comprising liver carboxylesterase 1 and liver cancer screening method
The present invention relates to a plasma biomarker for diagnosing hepatocellular carcinoma (HCC), in particular to the discovery of a protein in plasma using 2-D fluorescence differential gel...
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8198025 |
Method for diagnosing esophageal cancer
This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal...
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8198024 |
Gene expression markers for colorectal cancer prognosis
A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression...
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8194952 |
Image processing system and methods for aligning skin features for early skin cancer detection systems
Embodiments of an image processing system and methods for aligning features suitable for use in early skin-cancer detection systems are described herein. Corresponding skin features between a...
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8193333 |
Cancer therapy using Bcl-Xl-specific siNA
The invention relates to a double-stranded short interfering nucleic acid (siNA) molecule specific to the Bcl-XL transcript, comprising a sense and an antisense region, wherein the sense region...
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8193332 |
Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associated genes
The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation....
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8193328 |
Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents
This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was...
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8193309 |
Compositions and methods for preventing or treating cancer
The present invention relates to a MUC1 cytoplasmic tail peptide or portion thereof. These peptides are useful for inducing an immune response to MUC1-expressing tumor cells and thus for preventing...
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8193238 |
Inhibition of microtubule protrusion in cancer cells
The present invention generally concerns microtubule protrusions in cancer cells, including detached cancer cells, and inhibition of the protrusions. In particular aspects, the inhibition of the...
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8192935 |
Methods for assessing cisplatin resistance, disease progression, and treatment efficacy in ovarian cancer as related to MetAP2 expression
The invention provides methods for predicting whether an ovarian cancer patient's tumor will be resistant to chemotherapy. The invention also provides methods for monitoring the effectiveness of...
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8192931 |
Method to detect prostate cancer in a sample
The present invention relates to prostate cancer. More specifically, the present invention relates to a method to detect prostate cancer in a patient sample by detecting the RNA encoded by the gene...
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8192928 |
Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least...
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