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10071130 Methods and compositions related to Hsp90 inhibitors and breast cancer  
Embodiments of the invention are directed to methods of treating cancer cells, particularly breast cancer cells, such as chemo-resistant cells, with an Hsp90 inhibitor and an anticancer agent or...
10071076 Methods of treating cancer and other disorders  
Active compounds useful for inhibiting fatty acid synthase in a subject in need thereof are described. The active compounds are, in general, a 5-mercapto-1H-Indazole-4,7-dione or an analog...
10071066 Method of treating cancer using selective estrogen receptor modulators  
Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are...
10071056 Cancer cell targeting using nanoparticles  
The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of...
10071051 WT1 peptide cancer vaccine composition for transdermal administration  
The present invention provides a cancer vaccine composition for transdermal administration for cellular immunity induction, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a...
10070831 Integrated cancer therapy—imaging apparatus and method of use thereof  
The invention comprises a positively charged particle based cancer therapy system integrated with at least one off-axis imaging system, where elements of the off-axis imaging system and the cancer...
10066268 Methods of diagnosing or treating prostate cancer using the ERG gene, alone or in combination with other over or under expressed genes in prostate cancer  
The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof....
10066026 Chimeric small molecules for the recruitment of antibodies to cancer cells  
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The...
10066020 Methods of detecting cancer  
A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating CD14+ cells from a blood sample of the subject and determining...
10064929 Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10064923 Therapeutic cancer vaccines derived from a novel dendritic cell line  
The invention is in the field of medical sciences. It provides means and methods for the treatment of cancer. More in particular, it provides cells and cell lines that can be developed into fully...
10064913 Immunotherapy against several tumors including gastrointestinal and gastric cancer  
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present...
10064911 Peptides for treating cancer  
The present invention relates to peptides for inhibiting angiogenesis. The present invention also relates to methods of inhibiting angiogenesis and methods of treating disorders associated with...
10064885 Metabolic gene, enzyme, and flux targets for cancer therapy  
A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1,...
10064883 Lipiodol-based anti-tumour emulsion for treating cancer  
The present invention relates to a pharmaceutical composition including Lipiodol and a molecule with anti-tumor activity and secondarily a hydroxyethyl starch. The present invention also relates...
10064874 Methods of reducing mammographic breast density and/or breast cancer risk  
The present disclosure is directed to generally methods and/or compositions for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a pre-menopausal,...
10064834 Carbidopa for the treatment of cancer  
The present invention includes a method of inhibiting or reducing mTOR signaling or inhibition of indoleamine dioxygenase-1 (IDO1) in a subject with a proliferative disease, which comprises...
10064823 Nanoparticulate compositions for targeted delivery of acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation  
In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol...
10060926 Method for diagnosing and treating ovarian cancer  
Provided are a composition, a kit, and a method of predicting prognosis of ovarian cancer or a risk of recurrence of ovarian cancer. Provided are a composition for treating ovarian cancer or...
10059998 Microrna signature as an indicator of the risk of early recurrence in patients with breast cancer  
The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumors using the expression signature of...
10059740 Integrin interaction inhibitors for the treatment of cancer  
Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically...
10059721 Substituted thieno[3,2-b]pyrazines for inhibiting cancer cell proliferation and inducing cancer cell apoptosis  
The present invention relates to a novel 4-(aryl)-N-(2-alkoxythieno[3,2-b]pyrazin-3-yl)-piperazin-1-c arboxamide derivative compound useful in the prevention or treatment of cancer; a preparation...
10059702 Inhibitors of LC3/ATG3 interaction and their use in the treatment of cancer  
The present inventors discovered that the molecule pyridinylthiazolamine (PTA) specifically prevents the protein-protein interaction of hLC3 with hAtg3 in vitro and in cell based assays. The...
10058688 Medicament, method, and drug delivery device for treatment of ovarian cancer  
Drug delivery devices, medicaments, and methods are provided for the intraperitoneal treatment of ovarian cancer. An implantable device for drug delivery includes an elongated, flexible device...
10058610 Methods for treating cancer by administering humanized pan-HER antibody compositions  
The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one...
10058591 Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer  
The present invention relates to a combination of a parvovirus and a cytokine, preferably IFNy, for use in treating pancreatic cancer, in particular a terminal stage of this disease.
10058587 Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity  
The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity....
10058527 Composition containing monoacetyldiacylglycerol compound as active ingredient for inhibiting blood cancer or metastasis  
The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The...
10058523 Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis  
Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that...
10055842 Entropy-based radiogenomic descriptions on magnetic resonance imaging (MRI) for molecular characterization of breast cancer  
Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One...
10055542 Software interface tool for breast cancer screening  
What is disclosed is a software interface tool for breast cancer screening that is designed for medical professionals to view and analyze suspicious regions for hot spots and hence facilitate a...
10054596 Platelet biomarkers in cancer diagnosis  
The present embodiments relate generally to the field of cancer diagnostics. More specifically the embodiments relate to platelet derived biomarkers used for diagnosis of cancer or cancer...
10054590 Use of nucleolin as a biomarker for lymphangiogenesis in a cancer prognosis and therapy  
The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor...
10053737 Methods and compositions for treating cancer by identifying one or more ERK mutations  
The invention is directed to methods, reagents, and kits for the detection of MAPK/ERK pathway mutations in a patient diagnosed for cancer. In one embodiment, the invention comprises a sensitive...
10053696 MiRNA-489 in treatment of breast cancer  
Breast cancer treatment methods and materials incorporating microRNA-489 are described. The methods and materials have been developed from identification of a double-negative feedback loop between...
10053692 Methods relating to circulating tumor cell clusters and the treatment of cancer  
Described herein are methods and assays relating to the presence and/or level of circulating tumor cells (CTCs). These CTC-Cs represent a highly metastatic subpopulation of CTCs. In some...
10053512 Antibodies against claudin 18.2 useful in cancer diagnosis  
The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether...
10053494 Chemically activated nanocapsid functionalized for cancer targeting  
Modified capsid proteins containing at least a portion of hepatitis E virus (HEV) open reading frame 2 (ORF2) having one or more cysteine residues in a surface variable loop or the C-terminus of...
10052393 Multifunctional nanomaterials for the treatment of cancer  
The invention relates to a multifunctional nanomaterial comprising a nanorod comprising 1) a noble metal, wherein the nanorod exhibits surface plasmon resonance absorption in the near-infrared...
10052371 Compositions and methods for treatment of cancer using bacteria  
Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for...
10052370 HER2/Neu cancer vaccine  
Protein conjugate comprising a protein antigen for generating an immune response against the HER2/neu protein and an immunogenic carrier covalently bonded to said protein antigen, wherein said...
10052314 Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer  
Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
10052304 Compositions and methods for cancer therapy  
The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances...
10052085 Diagnostic assembly and method including cold bars for detecting a presence of cancer  
A diagnostic assembly (30, 320) and method for detecting a presence of cancer in a breast of a patient. The diagnostic assembly (20, 320) comprises a frame (22, 322), at least one cold bar (26,...
10049770 Prediction of recurrence of non-small cell lung cancer  
Methods, apparatus, and other embodiments associated with predicting non-small cell lung cancer (NSCLC) patient response to adjuvant chemotherapy therapy using radiomic features extracted from...
10048266 Diagnostic biomarkers and therapeutic targets for pancreatic cancer  
We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected...
10048264 Lung cancer biomarker  
The present invention relates to a lung cancer biomarker for diagnosing early stage lung cancers or predicting prognosis of lung cancers, which comprises a GM2AP protein. The present invention...
10047403 Diagnostic methods for determining prognosis of non-small cell lung cancer  
The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after...
10047402 RASAL1 is a major tumor suppressor gene in thyroid cancer  
The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for treating thyroid cancer. In certain embodiments, the...
10047401 Expression protein-coding and noncoding genes as prognostic classifiers in early stage lung cancer  
The invention provides novel biomarkers (four genes BRCA1, HIF1A, DLC1, and XPO1 alone or in combination of miR-21) for early stage lung cancer.