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9439898 Methods for novel drug discovery, treatment and selective targeting for gefitinib-resistant non-small-cell lung cancer harboring T790M mutation  
The present invention relates to methods for novel drug discovery, treatment and selective targeting for Gefitinib-resistant non-small-cell lung cancer (NSCLC) harboring an additional mutation, in...
9439887 Anti-cancer compositions and methods  
Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject...
9439882 Compounds and compositions for the treatment of cancer  
New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their...
9439878 Use of lumefantrine and related compounds in the treatment of cancer  
The present application discloses the use of the anti-malarial drug lumefantrine and related compounds in the treatment of cancer.
9435812 Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration  
The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be...
9434995 Breast cancer biomarker signatures for invasiveness and prognosis  
MicroRNA profiles transition from normal breast to ductal carcinoma in situ and transition to invasive ductal carcinoma (IDC) and methods of use thereof are described. Methods of diagnosis and...
9434994 Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by non-small cell lung cancer patients  
Disclosed are methods to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer.
9434775 Gene overexpressed in cancer  
Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding...
9434677 Natural and synthetic compounds for treating cancer and other diseases  
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder,...
9433686 Methods for treating castration resistant prostate cancer and metastasis by reducing B-cell number and/or function  
The invention provides methods for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal. In one embodiment the method comprises...
9433675 Combination therapy involving antibodies against claudin 18.2 for treatment of cancer  
The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric...
9433668 Prostate cancer vaccine  
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer....
9433667 Cancer vaccines and vaccination methods  
Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
9433654 Compositions containing broccoli seeds for treatment or preventing prostate cancer  
The invention relates to a composition for treating or preventing prostate cancer or the recurrence thereof; including a non-aqueous extract of non-germinated broccoli seeds of the Brassica...
9433648 Treating renal cancer with a whole, leech saliva extract  
Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing...
9433635 Effective treatment of ovarian cancer using triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only...
9433607 Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-carbohydrazide derivatives as an active ingredient  
The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydr azono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said...
9433604 Method for inhibiting growth of cancer cells  
A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Akt1,...
9429582 Tyrosine-phosphorylated WBP2, a novel cancer target and biomarker  
WW-binding protein 2 (WBP2) has been demonstrated in different studies to be a tyrosine kinase substrate, to activate ERĪ±/PR transcription and to play a role in breast cancer. However, the role of...
9429576 Compositions and methods for identifying and targeting cancer cells of alimentary canal origin  
Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
9429574 Cancer therapies and methods  
The present invention provides an inhibitor of the ubiquitin-proteasome system for use in treating cancer in a patient, wherein the patient is assessed to establish that the cancer is associated...
9428819 Method for synthesizing noble metal nanoparticles using dead cancer cells  
A method for preparing noble metal nanoparticles from dead cancer cells includes reacting an aqueous metal ion solution with an aqueous solution including dead cultured cancer cells to obtain a...
9428581 Pharmaceutical composition for treatment and/or prevention of gallbladder cancer  
Provided is an antibody effective for treatment and/or prevention of gallbladder cancer. A pharmaceutical composition for treatment and/or prevention of gallbladder cancer contains as an active...
9428540 Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents  
The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer...
9428510 Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing Trk  
The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of...
9428503 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating Cancer  
The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Q, R1, R2, R3, R4 and R5 have any of the meanings defined herein. The...
9428500 Alpha-carbolines for the treatment of cancer  
The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof, as well as to key intermediates towards...
9428447 Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer  
The present disclosure relates to novel compounds having vitamin D receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of...
9427480 Duocarmycin ADCs for use in treatment of endometrial cancer  
The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors expressing HER2, wherein the human solid tumor expressing...
9427477 Cancer treatments  
This document provides methods and materials related to treating cancer (e.g., skin cancer). For example, methods and materials relating to the use of a composition containing albumin-containing...
9427466 Nanoparticle-assisted ultrasound for breast cancer therapy  
Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be...
9427458 Methods for inhibiting cancer cell proliferation  
The present invention concerns methods of treating cancer and methods of inhibiting cancer cell proliferation, particularly methods of treating breast cancer, wherein the methods comprise...
9427435 Narcotic emulsion formulations for treatment of cancer pain  
Methods and compositions of treating a subject for cancer pain are provided. In the subject methods, a subject is treated for cancer pain by administering to the subject an effective amount of a...
9427429 Cancer diagnosis and imaging  
The present invention provides a method for imaging a disease or condition in a mammal which includes the steps of; administering a therapeutically effective amount of a cell cycle inhibitor to...
9423401 Compositions and methods for detecting cancer  
The invention provides sialylated glycans and antibodies that specifically bind to them. The invention's compositions and methods for using them are useful for early detection and diagnosis of cancer.
9422598 Method and kit for the prognosis of colorectal cancer  
A method and kit for the prognosis of colorectal cancer where the method includes the steps of: a) obtaining a peripheral blood sample and extracting total RNA from the sample, b) contacting the...
9422592 System and method of detecting RNAS altered by cancer in peripheral blood  
Analyzing peripheral blood RNA populations presents an effective, accurate, minimally invasive method of determining a patient's cancer status. Using circulating free RNA of the genes disclosed...
9422559 Production and utilization of a novel anti-cancer drug in therapy  
This invention generally relates to a design and method for developing novel anti-tumor and/or anti-cancer drugs, vaccines and therapies, using microRNA and/or its shRNA...
9422331 2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer  
Disclosed are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R1, R2, R3, R4 and R5 are described herein, and methods of using said compounds in the treatment...
9422303 Formulations of water-insoluble chemical compounds and methods of using a formulation of compound FL118 for cancer therapy  
Provided are compositions, methods of making the compositions, and methods of using the compositions. The compositions can be provided as pharmaceutical preparations for use in disease treatment,...
9422241 Demethylpenclomedine analogs and their use as anti-cancer agents  
This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders. In one...
9422234 Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer  
The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane antigen (PSMA), which is expressed by...
9421282 Method of preparing iodine seed for treating eye disease or cancer, and iodine seed prepared thereby  
The present invention provides a technique for adsorbing I-125 on a support for treating cancer and a method of preparing an I-125 seed using the same. Since a method of preparing iodine according...
9421264 Method of treating cancer using selective estrogen receptor modulators  
Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are...
9421220 Anti-cancer composition comprising alginate  
Biologically acceptable composition for the prophylaxis and/or treatment of colorectal cancer. The composition contains an iron chelator, and the composition is adapted for the selective targeting...
9421203 Sensitization of cancer cells to DNA damage by inhibiting kinases essential for DNA damage checkpoint control  
The invention provides methods for overriding cell cycle arrest in a tumor cell, which comprise inducing DNA damage in the cell, and contacting the cell with an amount of bosutinib or a bosutinib...
9421193 Benzothiazole derivatives and a use thereof for the treatment of cancer  
Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical...
9417244 Cadherins as cancer biomarkers  
Methods of isolating, enriching, capturing, identifying, or detecting the presence of, cancerous cells in a sample, e.g., a blood sample from a subject, by detecting the presence of one or more...
9417242 Method and system for detecting and differentiating cancer and sepsis in mammals using biomarkers  
The invention provides a method and system for developing and using diagnoses of cancer and sepsis in canine subjects using thymidine kinase (TK), c-reactive protein (CRP), and C-type natriuretic...
9417241 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine (TCPP) and kit for use with detecting cancer  
Presented is a kit containing TCPP for use in prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being...