Sign up


Match Document Document Title
8809352 Sulfonamides as inhibitors of Bcl-2 family proteins for the treatments of cancer  
The present invention includes novel compound and methods of treating a disease or disorder by antagonizing Bcl-2 family proteins, particularly compounds of formula (I): or pharmaceutically...
8809299 Combination therapy for the treatment of cancer  
Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent...
8809296 Apoptosis inducer for cancer cell  
The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer...
8809295 Composition containing inhibitors of the expression or activity of SH3RF2 for preventing or treating cancer  
The present invention relates to a composition comprising an inhibitor of the expression or activity of SH3 domain containing ring finger 2 (SH3RF2) for preventing or treating cancers. More...
8809291 Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma  
A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other...
8809289 Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer  
A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 21, and (b) an...
8809020 Method enabling the use of extracellular ribonucleic acid (RNA) extracted from plasma or serum to detect, monitor or evaluate cancer or premalignant conditions  
This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in blood plasma or serum fraction for the detection, monitoring, or...
8808997 Lung cancer markers, and uses thereof  
Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual...
8802895 Amide derivatives of benzene-sulfonanilide, pharmaceutical composition thereof and method for cancer treatment using the same  
The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The...
8802837 Nucleic acids molecule encoding the polypeptide for treating virus-induced cancer  
The present invention relates to nucleic acid molecules encoding the polypeptides that are capable of killing tumor cells. The molecules comprise a targeting agent covalently attached to a...
8802689 Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases  
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
8802649 Methods and compositions for inhibiting the proliferation of cancer cells  
A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an...
8802619 Cancer vaccine  
We disclose a vaccine comprising a pappalysin and vaccine compositions comprising a pappalysin.
8802397 Method of producing the polypeptide for treating virus-induced cancer  
The present invention relates to methods of producing the polypeptides that are capable of killing cells. The polypeptides comprise a targeting agent covalently attached to a channel-forming...
8802240 Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells  
Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also...
8802161 Herbal composition and method of use for the treatment of cancer  
The invention describes a nutraceutical composition and method for preventing/treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth...
8802113 Extracellular matrix cancer vaccine adjuvant  
Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an...
8802103 Compositions and methods for diagnosing and treating cancer  
Monoclonal antibodies that specifically bind to an extracellular domain of human Jagged 1 and inhibit growth of a tumor comprising cancer stem cells are described. Also described is a method of...
8796414 Identification and use of novopeptides for the treatment of cancer  
Disclosed are compositions relating to novopeptides identified by the presence of frameshift mutations in tumor genes previously not identified as being oncogenic. The disclosed peptides can be...
8796298 Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chIoro-4-(4-chIoro- 1 -methyl- 1 H-pyrazol-5-yl)-2-10 thiophenecarboxamide useful in the treatment of cancer  
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method...
8796220 Vaccine for the prevention of the recurrence HER2/neu expressing cancer  
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining protective...
8795976 Gene and polypeptide relating to breast cancer  
The present application provides novel human gene B7330N whose expression is markedly elevated in breast cancers. The gene and polypeptide encoded by the gene can be used, for example, in the...
8795738 Use of arsenic for cancer therapy protection  
A method of inhibiting damage to non-cancerous cells in a human subject during chemotherapeutic treatment or radiation treatment of cancer cells in the human subject includes administering to the...
8795672 Compositions and methods for cancer immunotherapy  
Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that...
8795662 Anti-mucin antibodies for early detection and treatment of pancreatic cancer  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The antibodies show...
8791435 Multi-field charged particle cancer therapy method and apparatus  
The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field charged particle cancer therapy method and apparatus coordinated with...
8791113 2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer  
The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by...
8791097 Anti-tumor activity of CCI-779 in papillary renal cell cancer  
This invention provides the method or use of CCI-779 in the treatment of papillary renal cell carcinoma.
8791094 Treatment of prostate cancer  
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen...
8790878 Diagnosis and treatment of breast cancer  
The present invention relates to compositions and methods for determining a treatment course of action. In particular, the present invention relates to compositions and methods for the prediction...
8790719 Phytocannabinoids in the treatment of cancer  
This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated...
8788017 Method and equipment for image-guided stereotactic radiosurgery of breast cancer  
A method of treating a cancerous region in a breast of a patient comprising (i) imaging the breast in a three-dimensional coordinate system, (ii) stereotactically determining the location of the...
8785614 Aberrantly methylated genes in pancreatic cancer  
The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that...
8785501 Anti-cancer tamoxifen-melatonin hybrid ligand  
A particularly constructed tamoxifen-melatonin hybrid ligand gives new and unexpectedly improved results in the prevention and treatment of cancer, particularly breast cancer. The hybrid ligand...
8785412 Method for inducing cancer cell apoptosis or inhibiting the cancer cell migration  
The present invention is related to a method for inducing the cancer cell apoptosis or inhibiting the cancer cell migration by inhibiting the expression of ribose-5-phosphate isomerase A.
8785409 Compounds having anti-adhesive effects on cancer cells  
Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3′→P5′ thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least...
8785405 Compounds for treating cancer and other diseases  
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder,...
8785392 Method for inhibiting cancer metastasis by administration of the extracellular domain DLK1 or a DLK1-FC fusion protein  
A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E...
8785373 Agents capable of downregulating an MSF-A-dependent HIF-1alpha and use thereof in cancer treatment  
Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of preventing the formation of or...
8785371 Drug delivery of temozolomide for systemic based treatment of cancer  
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a...
8785186 Hybrid cells for treating cancer patients  
The present invention relates to cancer treatment compositions and methods for treating a specific cancer patient population. In particular, the application describes methods of treating a patient...
8785131 Prognostic test for early stage non small cell lung cancer (NSCLC)  
The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical...
8785129 Method and probe set for detecting cancer  
Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset...
8784899 Compositions and methods for cancer treatment  
The present invention relates to compositions comprising a vitamin E analog and an arsenic compound for treating hyperproliferative cells disorders such as cancer. The composition of the invention...
8784811 Method of treating cancer using antibodies to a non-ligand binding region of NOTCH1  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8784796 Vaccine immunotherapy for treating hepatocellular cancer in immune suppressed patients  
A method for overcoming mild to moderate immune suppression includes the steps of inducing production of naive T-cells and restoring T-cell immunity. A method of vaccine immunotherapy includes the...
8784795 Methods for determining personalized treatment compositions for prostate cancer and breast cancer  
The present disclosure provides methods for selecting a treatment composition, or therapy, for the treatment of a cancer, such as prostate or breast cancer, in a patient wherein the treatment...
8784776 Use of FSH receptor ligands for diagnosis and therapy of cancer  
The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed...
8784772 Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model  
The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the regimen...
8778945 Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs  
Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of...