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9663484 Isoflavonoid compounds and methods for the treatment of cancer  
Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in...
9662405 Method of treating cancer by administering chimeric antigen receptor comprising anti-GCC antibody  
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the...
9662327 Phenyl and pyridinyl substituted piperidines and piperazines as inhibitors of IDH1 mutants and their use in treating cancer  
Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
9662303 Composition and method for treating cancer  
The present invention provides a compound for treating cancer including an isolated form of dibenzyl trisulfide (DTS) provided in an effective amount to act as an agent against human diseases,...
9662049 Methods and systems for monitoring patients undergoing treatment for cancer  
Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide...
9662019 Orbital angular momentum and fluorescence-based microendoscope spectroscopy for cancer diagnosis  
An apparatus for performing an endoscopic procedure for detecting cancerous tissue includes a detection probe for detecting the cancerous tissue. The detection probe includes a first fiber for...
9661737 Non-scaling fixed field alternating gradient permanent magnet cancer therapy accelerator  
A non-scaling fixed field alternating gradient accelerator includes a racetrack shape including a first straight section connected to a first arc section, the first arc section connected to a...
9657351 MRNA-based gene expression for personalizing patient cancer therapy with an MDM2 antagonist  
Use of at least an MDM2 gene panel, preferably a four gene MDM2 gene panel, as a biomarker for predicting the response to a MDM2 antagonist.
9657349 PME-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and gene silencing of PME-1 to inhibit epithelial to mesenchymal transition  
Disclosed are methods of attenuating activity of the PME-1 gene. siRNAs or shRNAs are used to target against PME-1, thereby reducing the PME-1 mRNA. It is disclosed that the siRNAs or shRNAs...
9657069 Anti-cancer compositions containing WNT decoy receptor  
The present invention relates to a composition for preventing or treating cancer comprising Wnt decoy receptor. The composition of the present invention or the expression product thereof inhibits...
9657068 Telomerase polypeptide vaccine for treating cancer  
A polypeptide comprising the sequence of SEQ. ID NO. 2, 3, 4, 7 or 8. The polypeptide may have the sequence of an immunogenic fragment thereof comprising at least eight amino acids, wherein the...
9657035 Method of treating cancer and gold(III) complexes as anti-cancer agents  
A method for treating cancer and gold(III) complexes with diaminocyclohexane ligand as anticancer agents. Also described are a pharmaceutical composition incorporating the gold(III) complexes and...
9656014 Method and device for treating cancer  
A method and device treats cancer where blood from a cancer patient passes through an array of passageways within an interior of a chamber. The passageways include wells having porous membrane...
9655980 Theranostic platform for targeted cancer therapy and drug delivery monitoring  
A compound that includes a quaterrylene dye moiety as core, and a dendrimeric shell. For example, the compound may comprise at least four dendronized polyamides covalently attached to a...
9655979 RNA trans-splicing molecule (RTM) for use in the treatment of cancer  
The present invention pertains to a novel pre-mRNA trans-splicing molecule (RTM) comprising a binding region which is complementary to a pre mRNA of a tumor associated gene, and a coding domain...
9655915 Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer  
Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in...
9655913 Anti-esophageal cancer compound and method of use thereof  
The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root of Lasia...
9655899 Compositions and methods for treating cancer  
The instant invention relates to methods for the treatment of WEE1 kinase associated cancer by administering a WEE1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable...
9655872 Treatment of cancer with specific RXR agonists  
A method of treating cancer is disclosed comprising administering to a patient in need of such treatment a RXR agonist at a level below the RAR activating threshold and at or above the RXR...
9655847 Therapeutic liposome and method of treating a subject having cancer  
A therapeutic liposome including a bilayer comprising at least one poly-unsaturated fatty acid (omega-3 fatty acid, omega-6 fatty acid, and omega-9 fatty acid), a beta-glucan, a cholesterol, and a...
9654745 Rapid multi-spectral imaging methods and apparatus and applications for cancer detection and localization  
Methods and apparatus for video rate or near video rate quantitative imaging of tissue physiological and morphological properties from visible/NIR light spectral images obtain rapid multi-spectral...
9653272 Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies  
A method and system for predicting in advance of treatment whether a cancer patient is likely, or not likely, to obtain benefit from administration of a yeast-based immune response generating...
9652844 Method and apparatus for automatic cancer diagnosis scoring of tissue samples  
Certain aspects of an apparatus and method for automatic ER/PR scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying a positive stained nucleus in a...
9651555 Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (ALK) as a marker  
Disclosed herein are methods for identifying a subject as having NSCLC that is predicted or is likely to respond to treatment with an ALK inhibitor, for example crizotinib. The methods include...
9651554 Molecular diagnostic methods for predicting brain metastasis of breast cancer  
Disclosed are molecular diagnostic compositions and methods for predicting brain metastasis of breast cancer, as well as methods for drug repositioning to identify existing and new therapeutics...
9650677 Use of gene expression profiling to predict survival in cancer patient  
Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to...
9650638 Aptamer for periostin and anti-cancer composition including same  
This disclosure relates to DNA aptamer specifically binding to periostin, which is cancer-related protein, a composition for inhibiting cancer and/or cancer metastasis and/or a composition for...
9650429 Soluble CD80 as a therapeutic to reverse immune suppression in cancer patients  
The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune...
9650428 Methods and compositions for treating cancer  
Described are compositions and methods relating to immune cells which express both a chimeric antigen receptor which binds to the IL13 receptor α-2 (IL13Rα2) and a O6-methylguanine DNA...
9649510 Multi-axis charged particle cancer therapy method and apparatus  
The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position,...
9649378 Cancer methods  
A method of treating a patient having a cancer in which HER2, HER4, FGFR1, EPHA2 and/or FGFR3 is upregulated and/or in which HER2, HER4, FGFR1, EPHA2 and/or FGFR3 mediated-signaling is...
9649316 Induction of tumor hypoxia for cancer therapy  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
9649313 Use of ITK inhibitors for the treatment of cancer  
This invention relates generally to the use of ITK (IL-2 inducible T-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that ITK...
9649312 Compositions and methods of treatment of cancer  
This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact (e.g., bind to) with MUC1 growth factor receptor or its...
9649305 PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic  
A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-pr op-2-en-1-one, is provided herein. (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-pr op-2-en-1-one is an...
9649300 Inhibition of WNT, TGF beta and Hippo signaling pathways to treat cancer, organ fibrosis and metabolic disorders  
Compounds, or pharmaceutically acceptable salts or esters thereof, having a structure of: wherein each of R1-R5 is individually selected from H, halogen, optionally substituted alkyl, optionally...
9649298 Cytotoxic substance for use in combination with radiotherapy in cancer treatment  
The present invention provides a substance comprising a preparation of at least one chemotherapeutic or cytotoxic substance for the use in treatment of a disease of a mammalian patient, especially...
9649292 Method for treating prostate cancer and/or gastrointestinal cancer  
Gold(III) complexes having mixed ligands as anticancer agents. The gold(III) complexes are coordinated to bidentate ligands having diamino functional groups: a diaminocyclohexane ligand and an...
9645154 Method for detecting cancer cell  
A method for detecting a cancer cell, including: contacting in vitro a peripheral blood-containing sample including test cells and a labeling substance; allowing the test cells to incorporate the...
9645152 Methods for predicting the survival time of a patient suffering from a solid cancer  
The present invention provides methods and kits for the prognosis of survival time of a patient suffering from a cancerous tumor. The method involves quantitating the density of Th17 cells at the...
9645151 Targeting phosphofructokinase and its glycosylation form for cancer  
The present invention relates to methods of treating cancer, suppressing or inhibiting tumorigenesis, tumor growth or cancer progression, and suppressing or inhibiting cancer cells from altering...
9644241 Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease  
Provided are methods and compositions for identifying a miRNA profile for a particular condition, such as pancreatic disease, and using the profile in assessing the condition of a patient.
9644029 Cancer diagnosis and treatment of cancer using anti-ROBO1 antibody  
A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody...
9643966 Compounds for the treatment of cancer and inflammatory diseases  
The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various conditions. The present invention also...
9643964 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-C]pyridine derivatives as NIK inhibitors for the treatment of cancer  
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14)...
9643923 Derivatives of indole for the treatment of cancer, viral infections and lung diseases  
The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral...
9642921 Cancer combination therapy and recombinant vectors  
This disclosure relates to a combination therapy of chemotherapeutics and/or radiosensitizing agents with a replication competent viral vectors for treating cell proliferative disorders and...
9642918 Combination of inotuzumab ozogamicin and torisel for the treatment of cancer  
The present invention relates to a therapeutic method for the treatment of cancer that comprises the use of a combination of inotuzumab ozogamicin (CMC-544) and temsirolimus. The enhanced...
9642859 Use of capsazepine and analogs thereof to treat cancer  
Disclosed are methods and compositions for treating cancer, particularly for reducing cancerous cell growth, for example, in solid tumors. Disclosed methods and compositions include capsazepine...
9642856 Treatment for pancreatic cancer  
The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt...