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US20120035184 |
METHODS FOR INDUCING TUMOR REGRESSION, INHIBITING TUMOR GROWTH, AND INDUCING APOPTOSIS IN BREAST TUMORS WITH GERANYLGERANYLTRANSFERASE I INHIBITORS
Methods of inducing tumor regression, inhibiting tumor growth, and inducing apoptosis with selective peptidomimetic inhibitors of geranylgeranyltransferase I (GGTase I), are provided. In one...
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8109816 |
Method and apparatus for measurement and analysis of a golf swing
A method for analyzing at least one golf swing parameter using a plurality of accelerometers located proximate the distal ends of a golf club, a signal processing and display system utilizing a...
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US20120021442 |
MARKERS FOR DETECTION OF COMPLICATIONS RESULTING FROM IN UTERO ENCOUNTERS
Described herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus, that...
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US20120009282 |
USE OF THE COMBINATION OF PHY906 AND A TYROSINE KINASE INHIBITOR AS A CANCER TREATMENT REGIMEN
This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life...
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8093299 |
Methods of treating bowel disorders
The present invention relates to methods for treating bowel disorders using calcimimetics.
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US20120004261 |
MIF MODULATORS
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low...
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8084471 |
Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha...
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8084258 |
Manipulation of tissue of organ type using the notch pathway
The present invention is directed to methods for altering the fate of a cell, tissue or organ type by altering Notch pathway function in the cell. The invention is further directed to methods for...
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8084228 |
Nogo-B receptor antagonists
Nogo-B receptors bind to Nogo-B and mediate its biological function. We have discovered that Nogo-B receptor is a component of endothelial cells, and is highly expressed in intact blood vessels....
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US20110313459 |
Dynamic Spine Stabilizer
A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured...
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US20110311538 |
INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF
The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V...
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8076451 |
Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide
A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a...
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8076347 |
Compounds and methods for the treatment of cancer
(−)-(2S,4S)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)cytosine (also referred to as (−)-OddC) or its derivative and its use to treat cancer in animals, including humans.
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US20110302583 |
SYSTEMS AND METHODS FOR PROCESSING DATA
A system, method, and computer program product for processing data are disclosed. The system includes a data processing framework configured to receive a data processing task for processing, a...
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US20110302226 |
DATA LOADING SYSTEMS AND METHODS
System, method, and computer program product for processing data are disclosed. The system is configured to perform transfer of data from a file system to a database system. Such transfer is...
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US20110302151 |
Query Execution Systems and Methods
System, method, and computer program product for processing data are disclosed. The method includes receiving a query for processing of data, wherein the data is stored in a table in a plurality of...
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US20110300152 |
COMPOSITIONS AND METHODS FOR MODULATING CELL-CELL FUSION VIA INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS
Compositions and methods are provided for modulating cell-cell fusion by using agents that modulate expression, activity, or function of intermediate-conductance calcium-activated potassium (SK4)...
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8071104 |
Neovascular-targeted immunoconjugates
Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The...
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US20110293750 |
ACTIVATED WNT-BETA-CATENIN SIGNALING IN MELANOMA
The present invention is directed to a method of determining the prospects for survival of a melanoma patient. This method involves providing a biological sample from a patient diagnosed with...
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US20110281358 |
System For Seeding Cells Onto Three Dimensional Scaffolds
Systems are provided for convenient and sterile isolation, collection, and seeding of cells onto a scaffold or tissue graft. The systems may be closed. Methods for use of the disclosed systems for...
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US20110280863 |
METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA
Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
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8058477 |
Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.
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8058314 |
Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
This invention provides the methodology and agents for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention of proteins....
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8036833 |
Systems and methods for automated analysis of cells and tissues
Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed.
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8035387 |
Methods and apparatus for compensating field inhomogeneities in magnetic resonance studies
One aspect of the present disclosure relates to a method or determining location(s) at which at least one magnetic article is to be positioned during a magnetic resonance imaging procedure of at...
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8034070 |
Varicose vein dissector and removal apparatus
A varicose vein dissector and removal apparatus includes a handle having a first end and a second end, a dissector extending from the first end of the handle and a hook extending from the second...
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8030456 |
Nogo receptor antagonists
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding...
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8026065 |
Assessment of oocyte competence
Methods are provided for evaluating an oocyte for fertilization and implantation. For example, methods are provided for determining whether an oocyte expresses, or does not express, one or more of...
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8017726 |
Anti-inflammatory compounds and uses thereof
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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8008262 |
β-peptides
β-peptide regions of polypeptides can serve as structural mimics of α-helices in wild type proteins. Because α-helices of one protein often bind to a target protein in a biological pathway, a po...
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US20110203994 |
Forward Osmosis Separation Processes
Separation processes using engineered osmosis are disclosed generally involving the extraction of solvent from a first solution to concentrate solute by using a second concentrated solution to draw...
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8002989 |
Osmotic desalination process
An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to...
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US20110201563 |
CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The...
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US20110196428 |
Method for stabilizing a spine
Spine stabilization devices, systems and methods are provided in which a single resilient member or spring is disposed on an elongate element that spans two attachment members attached to different...
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US20110196018 |
Nuclease resistant external guide sequences for treating inflammatory and viral related respiratory diseases
External Guide Sequence (EGS) are described that target proteins required for generation and modification of the immunoglobulin and T-cell repertoire that are useful for treatment or prevention of...
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7988951 |
Method for inducing selectively suppressed immune response to transplanted tissue or cells
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring...
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7988707 |
Dynamic spine stabilizer
A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured...
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7985583 |
Chlamydomonas intraflagellar transport 88 (IFT-88)
The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety, of...
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7985538 |
Drug resistance and methods of reversing
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to...
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US20110160119 |
ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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US20110144137 |
METHOD FOR PREVENTING OR ALLEVIATING THE NOXIOUS EFFECTS RESULTING FROM TOXICANT EXPOSURE
The present invention provides a method of using agents which can modulate TRPA1 function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to...
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US20110136743 |
Survivin, a protein that inhibits cellular apoptosis, and its modulation
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this...
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7951788 |
Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs
The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R1 is H, an acyl group, a C1-C20 alkyl or ether group, a phosphate,...
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US20110125003 |
Systems, Devices and Methods For Cartilage and Bone Grafting
Disclosed are systems, methods, devices and products to identify suitable donor sites for harvesting bone-cartilage grafts and to implant such bone-cartilage grafts. In some embodiments, a method...
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US20110117114 |
Neovascular-Targeted Immunoconjugates
Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The...
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US20110117094 |
Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury
Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo...
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7943130 |
Methods and compositions relating to CCR5 antagonist, IFN-γ and IL-13 induced inflammation
The present invention includes compositions and methods for the treatment of Th1 and/or Th2 medicated inflammatory diseases, relating to inhibiting CCR5. This is because the present invention...
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US20110104108 |
METHODS OF TREATING CANCER AND OTHER CONDITIONS OR DISEASE STATES USING LFMAU AND LDT
The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease...
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7935496 |
Diagnosis of preeclampsia
The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained...
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7932067 |
Detection, isolation and uses of renalase (monoamine oxidase C)
The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.
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