Patents and Patent Applications from Yale University


Match Document Document Title
9839208 Human SIRPα transgenic mice and their methods of use  
The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRPα that are engrafted with a human hematopoietic system. In various...
US20170342088 NOVEL ULK1 INHIBITORS AND METHODS USING SAME  
In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically...
US20170340789 CAVO-ARTERIAL PUMP  
The present invention provides an intravascular right ventricular assist device, i.e., the cavo-arterial pump (CAP). Two prototypes of the CAP were developed, including a direct drive CAP and a...
US20170340714 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same  
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the...
US20170340713 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same  
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the...
9828639 Identification of gene associated with reading disability and uses therefor  
The present invention relates to identification of a human gene, DCDC2 (MIM: 605755), associated with susceptibility for developing reading disability (RD), which is useful in identifying or...
US20170336399 NOVEL METHODS AND DEVICES FOR HIGH-THROUGHPUT QUANTIFICATION, DETECTION AND TEMPORAL PROFILING OF CELLULAR SECRETIONS, AND COMPOSITIONS IDENTIFIED USING SAME  
The present invention relates to the unexpected discovery of methods and devices that can be used for high-throughput precise quantification, detection and/or temporal profiling of cellular...
US20170334981 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF INHIBIT DNA REPAIR  
Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging...
US20170333533 Compositions and Methods for Treating Pathological Calcification and Ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
US20170333474 DRUG THERAPY TO INHIBIT CHEMOTHERAPY-INDUCED ADVERSE EFFECTS AND RELATED PHARMACEUTICAL COMPOSITIONS, DIAGNOSTICS, SCRREENING TECHNIQUES AND KITS  
The invention provides a method of treatment comprising reducing therapy-induced adverse effects (TIAE), including chemotherapy-induced adverse effects (CIAE), such as chemotherapy-induced...
9822364 Compositions and methods for controlled delivery of inhibitory ribonucleic acids  
Polymeric nanoparticles encapsulating inhibitory ribonucleic acids (RNAs) and methods of their manufacture and use are provided. Advantageous properties of the nanoparticles include: 1) high...
9822021 Forward osmosis separation processes  
Separation processes using forward osmosis are disclosed generally involving the extraction of a solvent from a first solution to concentrate a solute therein by using a second concentrated...
9820476 Genetically modified non-human animals and methods of use thereof  
The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
US20170326214 CD4 T cells provide antibody access to immunoprivileged tissue  
The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which...
US20170325977 Endovascular Graft Defining Internal Lumens  
An endovascular graft is provided that includes a stent structure adapted to move between a collapsed and a deployed configuration. An endovascular graft material is mounted with respect to the...
9818848 Three-dimensional ferroelectric FET-based structures  
Exemplary embodiments of the present disclosure are directed to three-dimensional (3D) Ferroelectric-gated FET (FeFET) structures that can be used to implement circuitry include memory cells,...
9814781 Environmentally sensitive compositions and methods of use thereof  
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
9808504 Immunogenic epitopes as targets for universal cancer vaccines  
The present invention provides a peptide having an amino acid sequence as set forth in SEQ ID NOs: 1 through 95 and any combination thereof. The peptide or combination of peptides possess OCT4...
US20170311803 METHODS, COMPUTER-READABLE MEDIA, AND SYSTEMS FOR MEASURING BRAIN ACTIVITY  
One aspect of the invention provides a method including: obtaining neural activity data for a first subject and a second subject during verbal interaction between the first subject and the second...
9801948 Antimicrobial compositions and methods of use thereof  
Antimicrobial compositions including a cell penetrating peptide (CPP) having the amino acid sequence Tyr-Ala-Arg-Val-Arg-Arg-Arg-Gly-Pro-Arg-Gly-Tyr-Ala-Arg-Val- Arg-Arg-Arg-Gly-Pro-Arg-Arg (SEQ...
US20170307614 Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same  
The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane...
US20170305948 NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME  
The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable...
US20170298114 Loss of Function mutations in KCNJ10 cause SeSAME, a human syndrome with sensory, neurological, and renal deficits  
The invention includes a method of identifying a human subject at-risk of developing SeSAME syndrome. The invention also includes a method of diagnosing a human subject afflicted with SeSAME...
9790605 Iridium complexes for electrocatalysis  
Solution-phase (e.g., homogeneous) or surface-immobilized (e.g., heterogeneous) electrode-driven oxidation catalysts based on iridium coordination compounds which self-assemble upon chemical or...
9789236 Implantable heart pump controller  
The present invention provides devices, systems, and methods for control of and communication with ventricular assist devices. In certain embodiments, the invention includes an implantable...
9788985 Friction-based orthotic impedence modulation device  
The present invention relates to an impedance modulation device for an orthotic application. The device includes a high-stiffness loading spring, a low-stiffness return spring, a shaft having an...
US20170291961 MULTIVALENT FRAGMENTS OF ANTIBODY 3E10 AND METHODS OF USE THEREOF  
Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain...
9786275 System and method for anomaly detection and extraction  
The present invention relates to a system for suppressing transient interference from a signal. The system includes a modeling system, wherein the modeling system constructs a model of transient...
9782522 Compositions and methods for treating and preventing neointimal stenosis  
Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGFβ inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a...
US20170283830 COMPOSITIONS FOR ENHANCING TARGETED GENE EDITING AND METHODS OF USE THEREOF  
Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing...
US20170281588 Compositions and Methods for Treating Epithelial Cancer  
The present invention provides the eutomeric isomer of the compound of formula (I), or a salt or solvate thereof, which can be used to treat epithelial cancer in a subject. In certain embodiments,...
US20170274054 Compositions and Methods for Modulating Coagulation  
The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.
US20170274041 Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury  
Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides,...
US20170274001 Compositions and Methods for Increasing Red Blood Cells  
The invention relates generally to a composition and method for increasing the frequency, amount, or presence of red blood cells in peripheral blood. In one embodiment, the invention comprises the...
US20170273772 Assemblies And Methodologies For The Repair Of Hernias  
An assembly for the repair of a hernia. The assembly includes an elongated shaft having a first end; a first holding member at least mostly positionable in the elongated shaft and a second holding...
US20170273285 Humanized M-CSF Mice  
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a...
US20170266325 COMPOSITIONS FOR NANOCONFINEMENT INDUCED CONTRAST ENHANCEMENT AND METHODS OF MAKING AND USING THEREOF  
Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR...
US20170266119 HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF  
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is...
9769399 Techniques for processing imaging data having sensor-dependent noise  
Techniques for processing imaging data contaminated by sensor-dependent noise. An imaging method is described. In the imaging method, imaging data corresponding to an imaged region and acquired by...
9764418 Joining of metallic glasses in air  
A method of joining a bulk metallic glass to a second similar or dissimilar material in an air environment. The method includes the steps of: a) removing an oxide layer on at least a portion of a...
9764109 Method of correlating brain activity  
The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner...
9758838 Compositions and methods for identifying secretory antibody-bound microbes  
The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and...
9758522 Hydrophobically tagged small molecules as inducers of protein degradation  
Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a...
US20170252414 Compositions and Methods for Treating Pathological Calcification and Ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
9750693 Liposome structures and methods of use thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the...
US20170251191 SYSTEMS, METHODS, AND COMPUTER-READABLE MEDIA FOR ULTRA-HIGH RESOLUTION 3D IMAGING OF WHOLE CELLS  
One aspect of the invention provides a method for drift correction to correct a 3D point collection dataset to compensate for drift over time. The method includes: (a) separating the 3D dataset...
US20170248611 METHOD AND PANEL FOR DETERMINING ACUTE KIDNEY INJURY  
A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration,...
9745334 Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use  
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through...
9744219 Compositions and methods for treating pathological calcification and ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
9744191 Antimicrobial compositions and methods  
Disclosed are compositions and methods for antimicrobial use. The compositions contain a small antimicrobial agent and a permeabilizing agent. The antimicrobial compositions can be antifungal or...