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US20090286754 |
Method of Treating Cancer and Other Conditions or Disease States Using L-Cytosine Nucleoside Analogs
The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R 1 is H, an acyl group, a C 1 -C 20 alkyl or ether group, a phosphate,...
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US20090286748 |
ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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US20090286736 |
ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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7618776 |
Rolling circle replication reporter systems
Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic...
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US20090281030 |
Genes Associated with Macular Degeneration
Identification of variant genes correlated with age related macular degeneration, such as variant LOC387715, variant SYNPR and variant PDGFC; methods of identifying or aiding in identifying...
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US20090258424 |
Cellular Delivery of siRNA
The invention provides a method for delivering a nucleic acid to a cell using a targeting molecule that is bound non-covalently to the nucleic acid. Compositions and kits are also provided.
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US20090253580 |
Growth of Boron Nanostructures with Controlled Diameter
A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such...
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US20090246183 |
eNOS mutations useful for gene therapy and therapeutic screening
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the...
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US20090239831 |
Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis
The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when...
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US20090239789 |
METHODS OF TREATMENT WITH DRUG LOADED POLYMERIC MATERIALS
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
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US20090234126 |
Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide
A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.
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7589078 |
Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections
The present invention relates to compounds according to the general formula:
wherein B is
or
and the remaining variables are defined in the specification, and compositions comprising...
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US20090221610 |
Compositions and Methods for Treating Cognitive Disorders
The present invention relates to the use of inhibitors or blockers of I h (hyperpolarization-activated cationic current) channels in the treatment of cognitive disorders. In preferred aspects of...
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US20090220586 |
PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha...
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US20090220427 |
Drug Resistance and Methods of Reversing
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to...
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US20090215842 |
Method of Treating Schizophrenia Prodrome
The present invention relates to a method of treating schizophrenia prodrome in human subjects using a NMDA glycine site agonist, a glycine transporter-1 inhibitor or mixtures thereof, optionally...
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US20090215691 |
NOGO Receptor Antagonists
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding...
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US20090214496 |
BMX/ETK TYROSINE KINASE GENE THERAPY MATERIALS AND METHODS
The present invention relates to materials and methods for the treatment of arterial diseases having impaired arteriogenesis and angiogenesis. More particularly, the invention provides materials...
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US20090202533 |
TREATMENT AND PROPHYLAXIS OF TH2 MEDIATED DISORDERS
The present invention provides a method for the treatment or prophylaxis of T-helper type 2 (Th2)-mediated disorders using antagonists of IL-11.
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7560029 |
Osmotic desalination process
An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to...
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7553821 |
Methods for selectively modulating survivin apoptosis pathways
The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the...
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7553674 |
Methods of identifying compounds useful for modulating intraflagellar transport
The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of...
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US20090162347 |
METHODS, COMPOSITIONS, AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
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7550154 |
Methods of treatment with drug loaded polymeric materials
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
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US20090155266 |
Methods and Compositions Relating to Vascular Endothelial Growth Factor and TH2 Mediated Inflammatory Diseases
The present invention includes compositions and methods for the treatment of a Th2 mediated inflammatory disease, relating to inhibiting a VEGF. The invention further includes methods to identify...
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US20090153139 |
Methods and Apparatus for Compensating Field Inhomogeneities in Magnetic Resonance Studies
One aspect of the present disclosure relates to a method or determining location(s) at which at least one magnetic article is to be positioned during a magnetic resonance imaging procedure of at...
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7546650 |
Adjustable surgical table
A surgical table includes a horizontal patient support with a base extending therefrom and supporting the patient support at a desired height. The surgical table also includes an adjustment...
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US20090149410 |
Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
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US20090148539 |
Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
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7541182 |
In vitro test to detect risk of preeclampsia
The present invention provides methods for identifying patients at risk of developing preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients...
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7538089 |
Anti-inflammatory compounds and uses thereof
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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7534858 |
Anti-inflammatory compounds and uses thereof
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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7534455 |
Herbal composition PHY906 and its use in chemotherapy
This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of...
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7534449 |
Targeted and high density drug loaded polymeric materials
Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to...
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7534448 |
Methods of treatment with drug loaded polymeric materials
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
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US20090125063 |
Dynamic Spine Stabilizer
A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured...
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7531892 |
Superconducting boron nanostructures
A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such...
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7531550 |
Pseudobase benzo[c]phenanthridines with improved efficacy, stability, and safety
Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I
are provided herein. The variables R, R 1 , R 2 , R 3 , and R 4 are defined herein. Certain...
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7531518 |
Method for fostering bone formation and preservation
A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood...
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US20090117595 |
PRIMARY CENTRAL NERVOUS SYSTEM TUMOR SPECIFIC BEHAB ISOFORMS
The present invention comprises compositions and methods related to a glycosylation-variant BEHAB protein, poly-sialyated full-length BEHAB, and methods of use thereof.
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US20090111753 |
Nogo-A Polypeptide Fragments, Variant Nogo Receptor-1 Polypeptides, and Uses Thereof
Nogo, MAG, and OMgp are myelin-derived proteins that bind to a neuronal Nogo-66 Receptor (NgR) to limit axonal regeneration after CNS injury. Nogo-A protein may play the most prominent role in...
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US20090099097 |
Enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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US20090099028 |
Protein binding miniature proteins and uses thereof
In certain aspects, the present invention provides miniature proteins resulted from a protein scaffold such as an avian pancreatic polypeptide that can be modified by substitution of at least one...
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7504486 |
Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
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US20090069241 |
Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments
The invention provides PEDF peptides which retain the biological activity of full-length PEDF. Fusion proteins comprising a PEDF peptide are also provided. The invention further provides a...
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US20090054325 |
Compositions and methods for suppressing axonal growth inhibition
The invention provides compositions and methods for interfering with Nogo-receptor mediated signaling and mediating axonal growth. The invention also provides methods for treating central nervous...
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7494976 |
Caveolin peptides and their use as therapeutics
The present invention relates generally to compositions and methods useful for treating various conditions and afflictions, such as inflammation and cancer. More specifically, the present invention...
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7494786 |
Mutant proteinase with reduced self-cleavage activity and method of purification
The present invention provides a mutant 27 kDa NIa proteinase having reduce self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant the same substrate...
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7485279 |
Growth of nanostructures with controlled diameter
Transition metal-substituted MCM-41 framework structures with a high degree of structural order and a narrow pore diameter distribution were reproducibly synthesized by a hydrothermal method using...
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7482483 |
Growth factor-binding compounds and methods of use
Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods...
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