Patents and Patent Applications from Yale University


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US20090286754 Method of Treating Cancer and Other Conditions or Disease States Using L-Cytosine Nucleoside Analogs  
The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R 1 is H, an acyl group, a C 1 -C 20 alkyl or ether group, a phosphate,...
US20090286748 ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
US20090286736 ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
7618776 Rolling circle replication reporter systems  
Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic...
US20090281030 Genes Associated with Macular Degeneration  
Identification of variant genes correlated with age related macular degeneration, such as variant LOC387715, variant SYNPR and variant PDGFC; methods of identifying or aiding in identifying...
US20090258424 Cellular Delivery of siRNA  
The invention provides a method for delivering a nucleic acid to a cell using a targeting molecule that is bound non-covalently to the nucleic acid. Compositions and kits are also provided.
US20090253580 Growth of Boron Nanostructures with Controlled Diameter  
A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such...
US20090246183 eNOS mutations useful for gene therapy and therapeutic screening  
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the...
US20090239831 Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis  
The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when...
US20090239789 METHODS OF TREATMENT WITH DRUG LOADED POLYMERIC MATERIALS  
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
US20090234126 Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide  
A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.
7589078 Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections  
The present invention relates to compounds according to the general formula: wherein B is or and the remaining variables are defined in the specification, and compositions comprising...
US20090221610 Compositions and Methods for Treating Cognitive Disorders  
The present invention relates to the use of inhibitors or blockers of I h (hyperpolarization-activated cationic current) channels in the treatment of cognitive disorders. In preferred aspects of...
US20090220586 PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES  
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha...
US20090220427 Drug Resistance and Methods of Reversing  
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to...
US20090215842 Method of Treating Schizophrenia Prodrome  
The present invention relates to a method of treating schizophrenia prodrome in human subjects using a NMDA glycine site agonist, a glycine transporter-1 inhibitor or mixtures thereof, optionally...
US20090215691 NOGO Receptor Antagonists  
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding...
US20090214496 BMX/ETK TYROSINE KINASE GENE THERAPY MATERIALS AND METHODS  
The present invention relates to materials and methods for the treatment of arterial diseases having impaired arteriogenesis and angiogenesis. More particularly, the invention provides materials...
US20090202533 TREATMENT AND PROPHYLAXIS OF TH2 MEDIATED DISORDERS  
The present invention provides a method for the treatment or prophylaxis of T-helper type 2 (Th2)-mediated disorders using antagonists of IL-11.
7560029 Osmotic desalination process  
An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to...
7553821 Methods for selectively modulating survivin apoptosis pathways  
The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the...
7553674 Methods of identifying compounds useful for modulating intraflagellar transport  
The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of...
US20090162347 METHODS, COMPOSITIONS, AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
7550154 Methods of treatment with drug loaded polymeric materials  
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
US20090155266 Methods and Compositions Relating to Vascular Endothelial Growth Factor and TH2 Mediated Inflammatory Diseases  
The present invention includes compositions and methods for the treatment of a Th2 mediated inflammatory disease, relating to inhibiting a VEGF. The invention further includes methods to identify...
US20090153139 Methods and Apparatus for Compensating Field Inhomogeneities in Magnetic Resonance Studies  
One aspect of the present disclosure relates to a method or determining location(s) at which at least one magnetic article is to be positioned during a magnetic resonance imaging procedure of at...
7546650 Adjustable surgical table  
A surgical table includes a horizontal patient support with a base extending therefrom and supporting the patient support at a desired height. The surgical table also includes an adjustment...
US20090149410 Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
US20090148539 Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
7541182 In vitro test to detect risk of preeclampsia  
The present invention provides methods for identifying patients at risk of developing preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients...
7538089 Anti-inflammatory compounds and uses thereof  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
7534858 Anti-inflammatory compounds and uses thereof  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
7534455 Herbal composition PHY906 and its use in chemotherapy  
This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of...
7534449 Targeted and high density drug loaded polymeric materials  
Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to...
7534448 Methods of treatment with drug loaded polymeric materials  
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
US20090125063 Dynamic Spine Stabilizer  
A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured...
7531892 Superconducting boron nanostructures  
A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such...
7531550 Pseudobase benzo[c]phenanthridines with improved efficacy, stability, and safety  
Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R 1 , R 2 , R 3 , and R 4 are defined herein. Certain...
7531518 Method for fostering bone formation and preservation  
A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood...
US20090117595 PRIMARY CENTRAL NERVOUS SYSTEM TUMOR SPECIFIC BEHAB ISOFORMS  
The present invention comprises compositions and methods related to a glycosylation-variant BEHAB protein, poly-sialyated full-length BEHAB, and methods of use thereof.
US20090111753 Nogo-A Polypeptide Fragments, Variant Nogo Receptor-1 Polypeptides, and Uses Thereof  
Nogo, MAG, and OMgp are myelin-derived proteins that bind to a neuronal Nogo-66 Receptor (NgR) to limit axonal regeneration after CNS injury. Nogo-A protein may play the most prominent role in...
US20090099097 Enzyme inhibition  
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
US20090099028 Protein binding miniature proteins and uses thereof  
In certain aspects, the present invention provides miniature proteins resulted from a protein scaffold such as an avian pancreatic polypeptide that can be modified by substitution of at least one...
7504486 Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes  
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
US20090069241 Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments  
The invention provides PEDF peptides which retain the biological activity of full-length PEDF. Fusion proteins comprising a PEDF peptide are also provided. The invention further provides a...
US20090054325 Compositions and methods for suppressing axonal growth inhibition  
The invention provides compositions and methods for interfering with Nogo-receptor mediated signaling and mediating axonal growth. The invention also provides methods for treating central nervous...
7494976 Caveolin peptides and their use as therapeutics  
The present invention relates generally to compositions and methods useful for treating various conditions and afflictions, such as inflammation and cancer. More specifically, the present invention...
7494786 Mutant proteinase with reduced self-cleavage activity and method of purification  
The present invention provides a mutant 27 kDa NIa proteinase having reduce self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant the same substrate...
7485279 Growth of nanostructures with controlled diameter  
Transition metal-substituted MCM-41 framework structures with a high degree of structural order and a narrow pore diameter distribution were reproducibly synthesized by a hydrothermal method using...
7482483 Growth factor-binding compounds and methods of use  
Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods...