Patents and Patent Applications from Yale University


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US20180163210 COMPOSITIONS AND METHODS FOR CONTROLLING VASCULATURE  
The invention relates to compositions and methods for reducing excessive vascular development and treat related disorders. In one aspect, the invention provides methods for treating, reducing or...
US20180162813 MIF MODULATORS  
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low...
9994905 Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome  
Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described...
US20180155332 SMALL MOLECULE BASED ANTIBODY-RECRUITING COMPOUNDS FOR CANCER TREATMENT  
The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including...
US20180153978 TUMORS EXPRESSING IgG1 Fc INDUCE ROBUST CD8 T CELL RESPONSES  
A lymphoma cell line was engineered to express surface IgG1 Fc. These tumor cells were taken up rapidly by DCs, leading to enhanced cross-presentation of tumor-derived antigen to CD8 T cells....
9988684 Predicting gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs)  
Described are embodiments related to gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) biomarkers and agents, systems, and kits for detecting the same, and associated GEP-NEN diagnostic,...
9987381 Radioligands for imaging the LPA-1 receptor  
The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.
9987353 Virus like vesicles (VLVS) based vaccines to prevent or treat chronic hepatitis B virus (HBV) infection  
The present invention relates to the discovery of compositions and methods for therapeutic immunization for treatment of chronic hepatitis B. Methods of the invention include a method generating...
9986734 Human and large-mammal lung bioreactor  
The present invention provides a bioreactor for large-mammal lung tissue. The bioreactor is capable of hydraulic driven negative-pressure and positive-pressure perfusion and ventilation. Perfusion...
9986724 Genetically modified non-human animals and methods of use thereof  
Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a...
US20180152003 A METHOD AND DEVICE CONCERNING III-NITRIDE EDGE EMITTING LASER DIODE OF HIGH CONFINEMENT FACTOR WITH LATTICE MATCHED CLADDING LAYER  
Edge-emitting laser diodes having high confinement factors and lattice-matched, porous cladding layers are described. The laser diodes may be formed from layers of III-nitride material. A cladding...
9982026 Compositions and methods for assessing and treating adrenal diseases and disorders  
The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions and methods for the assessment,...
9982009 Methods for treating polycystic kidney disease and polycystic liver disease  
The present invention provides compounds of Formula (I) or (II), which are thought to be able to inhibit mTOR (mammalian target of rapamycin) signaling pathway, induce UPR (unfolded protein...
9981066 Anti-thrombogenic grafts  
The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an...
9978845 Method of obtaining planar semipolar gallium nitride surfaces  
Methods and structures for forming flat, continuous, planar, epitaxial layers of semipolar III-nitride materials on patterned sapphire substrates are described. Semipolar GaN may be grown from...
9978589 Nitrogen-polar semipolar and gallium-polar semipolar GaN layers and devices on sapphire substrates  
Methods and structures for forming epitaxial layers of semipolar III-nitride materials on patterned sapphire substrates are described. Semi-nitrogen-polar GaN may be grown from inclined c-plane...
US20180138987 WIRELESS JOSEPHSON PARAMETRIC CONVERTER  
A wireless Josephson-junction-based parametric converter is described. The converter may be formed on a substrate with antennas that pump are configured to wirelessly receive pump, signal and...
US20180128729 Label-Free Cellular Manipulation and Sorting Via Biocompatible Ferrofluids  
A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one output, and a length...
US20180126014 COMPOSITIONS FOR ENHANCING DELIVERY OF AGENTS ACROSS THE BLOOD BRAIN BARRIER AND METHODS OF USE THEREOF  
Compositions and methods for improved delivery of active agents to the brain are provided. The compositions typically include a nanocarrier, such as a polymeric nanoparticle, liposome, or...
US20180119449 CHANNEL GASKET AND PLUG FOR ELECTROMECHANICAL LOCK  
An electronic lock housing for the inside surface of a door with an opening therethrough has an interior portion for receiving electronic components for a door lock, a back portion with channels,...
US20180119224 IDENTIFICATION OF GENE ASSOCIATED WITH READING DISABILITY AND USES THEREFOR  
The present invention relates to identification of a human gene, DCDC2 (MIM: 605755), associated with susceptibility for developing reading disability (RD), which is useful in identifying or...
US20180119099 COMPOSITIONS AND METHODS FOR DIMINISHING AN IMMUNE RESPONSE  
The invention is based upon the discovery that T regulatory type 1 (Tr1) cells express particular cell surface markers that allow for their selection, enrichment, isolation, purification and...
US20180117183 FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH-TRIGGERED POLYPEPTIDE  
The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying,...
9951349 Compositions and methods for transient expression of recombinant RNA  
Compositions for transient but prolonged exogenous mRNA expression through the use of the transcription system of negative strand RNA viruses, and methods of use thereof are disclosed. In some...
US20180108228 ACCESS CONTROL SYSTEM AND METHOD  
An access control system cooperates with a security system. The access control system may be used to control aspects of the security system and the security system may be used to control aspects...
US20180105854 COMPOSITIONS AND METHODS FOR MAKING SELENOCYSTEINE CONTAINING POLYPEPTIDES  
Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally...
9948254 Wireless Josephson bifurcation amplifier  
A wireless Josephson-junction-based amplifier is described that provides improved tunability and increased control over both a quality factor Q and participation ratio p of the amplifier. The...
US20180101642 52-GENE SIGNATURE IN PERIPHERAL BLOOD IDENTIFIES A GENOMIC PROFILE ASSOCIATED WITH INCREASED RISK OF MORTALITY AND POOR DISEASE OUTCOMES IN IDIOPATHIC PULMONARY FIBROSIS  
The clinical course of idiopathic pulmonary fibrosis (IPF) is difficult to predict. Described herein is a peripheral blood 52-gene expression signature useful to improve outcome prediction in IPF.
9938503 Differentiation of human iPS cells to human alveolar type II via definitive endoderm  
The present invention relates to compositions and methods for generating populations of tissue precursor cells from pluripotent cells, and preferably induction of stem cells into definitive...
9938324 FRET-based reagents and methods for identifying anti-HIV compounds  
A modified HIV gp120 protein labeled with a fluorophore has been used herein in single-molecule imaging techniques to demonstrate the conformation states of HIV-1 Env. The introduction of small...
9938264 Proteolysis targeting chimera compounds and methods of preparing and using same  
The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase...
9937466 Ultraviolet and hydrogen peroxide or ozone or ozone and hydrogen peroxide treatment to simultaneously control nitrosamine, nitramine, amine and aldehyde emissions from amine-based carbon capture  
Apparatuses for controlling emissions of carbon capture facilities and associated methods are disclosed that generally involve a chamber defining at least one washwater packing. The exemplary...
US20180093990 HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION  
Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a...
D814265 Door lock escutcheon  
US20180085496 FERROMAGNETIC PARTICLES BOUND TO POLYMERIC IMPLANTS  
It has been discovered that iron-platinum magnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to, polymeric materials, especially hydrogels, and...
US20180085459 IRON PLATINUM PARTICLES FOR ADHERENCE OF BIOLOGICS ON MEDICAL IMPLANTS  
It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized....
US20180080086 FISH PANEL FOR CTCL  
Described herein are probes useful to detect gene copy number alterations of genes characteristic/indicative of cutaneous T cell lymphoma (CTCL), such as CTCL with blood involvement, including...
9922256 Subject sensing in an environment  
A multimodal sensor network is designed to extract a plurality of fundamental properties associated with subject sensing. In one aspect, such network can combine cameras distributed in an...
9921216 Nanoelectronic-enzyme linked immunosorbent assay system and method  
The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway...
9920113 Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices  
Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species...
9919088 Implantable heart pump controller  
The present invention provides devices, systems, and methods for control of ventricular assist devices. The invention includes an implantable controller that is operatively programmed to direct...
9914709 Compositions and methods of treating HIV-1 infections using same  
The present invention includes novel compositions useful for preventing or treating an HIV-1 infection in a subject in need thereof. The present invention further includes a novel method of...
9913881 Compositions and methods for treating pathological calcification and ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
9913819 Methods of treating or preventing fibrotic lung diseases  
The invention includes a method of preventing or treating a fibrotic lung disease in a subject, comprising administering to the subject a thyroid hormone by inhalation and/or aerosolization. The...
US20180069288 TECHNIQUES FOR COUPLING PLANAR QUBITS TO NON-PLANAR RESONATORS AND RELATED SYSTEMS AND METHODS  
According to some aspects, a quantum mechanical system is provided, comprising a resonator having a plurality of superconducting surfaces and configured to support at least one electromagnetic...
US20180066253 METHODS AND COMPOSITIONS FOR MODIFYING ENDOTHELIAL CELLS  
The present invention includes methods and compositions for modifying endothelial cells for improved vascular self-assembly. In some embodiments, the invention includes a modified endothelial cell...
US20180064902 METHOD OF CORRELATING BRAIN ACTIVITY  
The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner...
US20180064786 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same  
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the...
US20180064648 Liposome Structures And Methods of Use Thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the...
9908915 Cell-penetrating compositions and methods using same  
An isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell, is described. The transport peptide can be incorporated into a transport construct in which...