Patents and Patent Applications from Yale University


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US20180040935 JOSEPHSON JUNCTION-BASED CIRCULATORS AND RELATED SYSTEMS AND METHODS  
According to some aspects, a circuit is provided comprising a plurality of Josephson junctions arranged in series in a loop, at least one magnetic element producing magnetic flux through the loop,...
9884026 Modular particles for immunotherapy  
Nanoparticulate compositions are disclosed. The nanoparticulate compositions typically include at least one, preferably two or more, active agent(s), one of which is an immunomodulatory compound,...
US20180032895 TECHNIQUES FOR UNIVERSAL QUANTUM CONTROL OF QUANTUM COHERENT STATES AND RELATED SYSTEMS AND METHODS  
Some aspects are directed to a method of operating an apparatus, the apparatus comprising a first quantum system having a plurality of coherent quantum states, the first quantum system being...
US20180030517 Compositions and methods for identifying secretory antibody-bound microbes  
The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and...
US20180030018 MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE  
Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively...
US20180020647 Genetically Modified Non-Human Animals And Methods Of Use Thereof  
The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
9867870 Compositions and methods for treating hemophilia  
The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.
US20180008705 USE OF MIF AND MIF PATHWAY AGONISTS  
The present invention relates to novel methods and compositions for increasing AMPK activity and glucose uptake comprising administering a macrophage migration inhibitory factor (MIF) pathway...
US20180008679 COMPOSITIONS AND METHODS OF INCREASING LONGEVITY OR TREATING CELLULAR STRESS  
The present invention includes methods and compositions for increasing longevity of a cell and increasing cellular resistance to stress. In certain embodiments, the invention includes a method to...
US20180008629 Compositions and Methods for Treating NLRP3 Inflammasome-Related Diseases and Disorders  
The present invention provides compositions and methods for treating or preventing an NLRP3 immunosome-related disorder. In one embodiment, the method includes administering a therapeutically...
US20180000911 Mosquito Saliva Protein Malaria Vaccine  
The invention provides compositions and methods for preventing and treating infection by Plasmodium sporozoites.
US20180000465 INTEGRATED PAINLESS BONE MARROW BIOPSY DEVICE  
An apparatus and method for performing painless bone marrow biopsy that requires only a single procedural pass to the biopsy bone site is disclosed. The biopsy device combines dermatotomy,...
9855370 Compositions and methods for promoting patency of vascular grafts  
Methods for increasing the patency of biodegradable, synthetic vascular grafts are provided. The methods include administering one or more cytokines and/or chemokines that promote outward tissue...
9849025 Brain cooling system  
A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable,...
US20170360959 FORMULATIONS FOR TARGETED RELEASE OF AGENTS UNDER LOW PH CONDITIONS AND METHODS OF USE THEREOF  
Poly(amine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The...
US20170360775 GLUTAMATE AGENTS IN THE TREATMENT OF MENTAL DISORDERS  
Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate...
US20170360724 METHODS OF PREVENTING NEURODEGENERATION OF ASSOCIATION CORTEX IN A MAMMAL  
The present invention provides methods of preventing and/or reducing risk of neurodegeneration of association cortex, and/or inhibiting or reversing formation of phosphorylated tau or COXIV in the...
9846162 Immune biomarkers and assays predictive of clinical response to immunotherapy for cancer  
The present invention relates to predictors of a cancer patient's responsiveness to immunotherapy for cancer.
9844585 Convection enhanced delivery apparatus, method, and application  
An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual...
US20170356920 METHODS AND KITS FOR DETECTING MISFOLDED PROTEINS  
Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
US20170355755 COMPOSITIONS AND METHODS FOR MODULATING SALM5 AND HVEM  
The invention provides compositions and methods for regulating immune responses. In one embodiment, compositions of the invention include one or more SALM5-HVEM antagonists that are able to induce...
US20170354719 Compositions and Methods for Treating Pathological Calcification and Ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
9839208 Human SIRPĪ± transgenic mice and their methods of use  
The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRPĪ± that are engrafted with a human hematopoietic system. In various...
US20170342088 NOVEL ULK1 INHIBITORS AND METHODS USING SAME  
In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically...
US20170340789 CAVO-ARTERIAL PUMP  
The present invention provides an intravascular right ventricular assist device, i.e., the cavo-arterial pump (CAP). Two prototypes of the CAP were developed, including a direct drive CAP and a...
US20170340714 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same  
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the...
US20170340713 Compositions for Treating Pathological Calcification Conditions, and Methods Using Same  
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the...
9828639 Identification of gene associated with reading disability and uses therefor  
The present invention relates to identification of a human gene, DCDC2 (MIM: 605755), associated with susceptibility for developing reading disability (RD), which is useful in identifying or...
US20170336399 NOVEL METHODS AND DEVICES FOR HIGH-THROUGHPUT QUANTIFICATION, DETECTION AND TEMPORAL PROFILING OF CELLULAR SECRETIONS, AND COMPOSITIONS IDENTIFIED USING SAME  
The present invention relates to the unexpected discovery of methods and devices that can be used for high-throughput precise quantification, detection and/or temporal profiling of cellular...
US20170334981 CELL-PENETRATING ANTI-DNA ANTIBODIES AND USES THEREOF INHIBIT DNA REPAIR  
Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging...
US20170333533 Compositions and Methods for Treating Pathological Calcification and Ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
US20170333474 DRUG THERAPY TO INHIBIT CHEMOTHERAPY-INDUCED ADVERSE EFFECTS AND RELATED PHARMACEUTICAL COMPOSITIONS, DIAGNOSTICS, SCRREENING TECHNIQUES AND KITS  
The invention provides a method of treatment comprising reducing therapy-induced adverse effects (TIAE), including chemotherapy-induced adverse effects (CIAE), such as chemotherapy-induced...
9822364 Compositions and methods for controlled delivery of inhibitory ribonucleic acids  
Polymeric nanoparticles encapsulating inhibitory ribonucleic acids (RNAs) and methods of their manufacture and use are provided. Advantageous properties of the nanoparticles include: 1) high...
9822021 Forward osmosis separation processes  
Separation processes using forward osmosis are disclosed generally involving the extraction of a solvent from a first solution to concentrate a solute therein by using a second concentrated...
9820476 Genetically modified non-human animals and methods of use thereof  
The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
US20170326214 CD4 T cells provide antibody access to immunoprivileged tissue  
The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which...
US20170325977 Endovascular Graft Defining Internal Lumens  
An endovascular graft is provided that includes a stent structure adapted to move between a collapsed and a deployed configuration. An endovascular graft material is mounted with respect to the...
9818848 Three-dimensional ferroelectric FET-based structures  
Exemplary embodiments of the present disclosure are directed to three-dimensional (3D) Ferroelectric-gated FET (FeFET) structures that can be used to implement circuitry include memory cells,...
9814781 Environmentally sensitive compositions and methods of use thereof  
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
9808504 Immunogenic epitopes as targets for universal cancer vaccines  
The present invention provides a peptide having an amino acid sequence as set forth in SEQ ID NOs: 1 through 95 and any combination thereof. The peptide or combination of peptides possess OCT4...
US20170311803 METHODS, COMPUTER-READABLE MEDIA, AND SYSTEMS FOR MEASURING BRAIN ACTIVITY  
One aspect of the invention provides a method including: obtaining neural activity data for a first subject and a second subject during verbal interaction between the first subject and the second...
9801948 Antimicrobial compositions and methods of use thereof  
Antimicrobial compositions including a cell penetrating peptide (CPP) having the amino acid sequence Tyr-Ala-Arg-Val-Arg-Arg-Arg-Gly-Pro-Arg-Gly-Tyr-Ala-Arg-Val- Arg-Arg-Arg-Gly-Pro-Arg-Arg (SEQ...
US20170307614 Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same  
The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane...
US20170305948 NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME  
The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable...
US20170298114 Loss of Function mutations in KCNJ10 cause SeSAME, a human syndrome with sensory, neurological, and renal deficits  
The invention includes a method of identifying a human subject at-risk of developing SeSAME syndrome. The invention also includes a method of diagnosing a human subject afflicted with SeSAME...
9790605 Iridium complexes for electrocatalysis  
Solution-phase (e.g., homogeneous) or surface-immobilized (e.g., heterogeneous) electrode-driven oxidation catalysts based on iridium coordination compounds which self-assemble upon chemical or...
9789236 Implantable heart pump controller  
The present invention provides devices, systems, and methods for control of and communication with ventricular assist devices. In certain embodiments, the invention includes an implantable...
9788985 Friction-based orthotic impedence modulation device  
The present invention relates to an impedance modulation device for an orthotic application. The device includes a high-stiffness loading spring, a low-stiffness return spring, a shaft having an...
US20170291961 MULTIVALENT FRAGMENTS OF ANTIBODY 3E10 AND METHODS OF USE THEREOF  
Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain...
9786275 System and method for anomaly detection and extraction  
The present invention relates to a system for suppressing transient interference from a signal. The system includes a modeling system, wherein the modeling system constructs a model of transient...