Patents and Patent Applications from Yale University


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US20100024423 Osmotic Heat Engine  
A method of converting thermal energy into mechanical work that uses a semi-permeable membrane to convert osmotic pressure into electrical power. A closed cycle pressure-retarded osmosis (PRO)...
US20100016739 Method of Assessing Blood Volume Using Photoelectric Plethysmography  
A method and system for assessing blood volume within a subject includes generating a cardiovascular waveform representing physiological characteristics of a subject and determining blood volume of...
US20100016262 Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis  
The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when...
7648965 Method for fostering bone formation and preservation  
A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood...
7648700 Method for fostering bone formation and preservation  
A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood...
US20100009397 SUBSTRATE-MIMETIC AKT INHIBITOR  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue...
US20090325790 SIZE-CONTROLLABLE TRANSITION METAL CLUSTERS IN MCM-41 FOR IMPROVING CHEMICAL CATALYSIS  
A metal-substituted mesoporous oxide framework, such as Co-MCM-41, are disclosed which includes more than one ion species with different reduction kinetics. The reducibility correlates strongly...
US20090318684 ROCK INHIBITORS AND USES THEREOF  
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that...
US20090318491 Cytisine and Acetylcholine Analogs and Methods of Treating Mood Disorders  
The present invention relates to compounds which are derivatives of cytisine or acetylcholine which exhibit activity as agonists, partial agonists or antagonists of nicotinic acetylcholine...
US20090318367 Use of SH2 STAT3/STAT1 Peptidomimetics as Anticancer Drugs  
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics...
US20090317457 ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN B-4  
The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-β4 polypeptide or a functional...
7632805 Growth factor binding molecules  
Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid...
US20090305971 Nogo-B Receptor  
Nogo-B receptors bind to Nogo-B and mediate its biological function. We have discovered that Nogo-B receptor is a component of endothelial cells, and is highly expressed in intact blood vessels....
US20090305259 Early Diagnosis of Congenital Abnormalities in the Offspring of Diabetic Mothers  
The present invention relates to the identification of a series of biomarkers, the detection of which is prognostic for women at risk of becoming hyperglycemic during pregnancy and/or fetuses at...
US20090297523 Erm family binding agents and their use in diagnosis and treatment of proliferative conditions  
The methods and compositions of the invention provide new diagnostic markers for cancers (e.g., ovarian cancer, PPC, etc.) and other proliferative diseases or conditions such as psoriasis and...
US20090297431 Multi-Stage Column Distillation (MSCD) Method for Osmotic Solute Recovery  
A method and apparatus for separating draw solution solutes and product solvent from a draw solution using a plurality of distillation columns. In one embodiment, the draw solution is used in a...
7625567 Induction of immune responses to isoaspartyl-modified antigens  
The present invention is directed to a method of enhancing the immune response of a patient relative to the normal immune response, by administering isoaspartyl-modified proteins, peptides, or...
7625557 Method for inducing selectively suppressed immune response to transplanted tissue or cells  
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring...
7621276 Intrauterine fallopian tube occlusion device  
An occlusion device for actively occluding orifices of fallopian tubes includes a resilient body having an elongated member with a first end and a second end. The elongated member further includes...
US20090286754 Method of Treating Cancer and Other Conditions or Disease States Using L-Cytosine Nucleoside Analogs  
The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R 1 is H, an acyl group, a C 1 -C 20 alkyl or ether group, a phosphate,...
US20090286748 ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
US20090286736 ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
7618776 Rolling circle replication reporter systems  
Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic...
US20090281030 Genes Associated with Macular Degeneration  
Identification of variant genes correlated with age related macular degeneration, such as variant LOC387715, variant SYNPR and variant PDGFC; methods of identifying or aiding in identifying...
US20090258424 Cellular Delivery of siRNA  
The invention provides a method for delivering a nucleic acid to a cell using a targeting molecule that is bound non-covalently to the nucleic acid. Compositions and kits are also provided.
US20090253580 Growth of Boron Nanostructures with Controlled Diameter  
A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such...
US20090246183 eNOS mutations useful for gene therapy and therapeutic screening  
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the...
US20090239831 Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis  
The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when...
US20090239789 METHODS OF TREATMENT WITH DRUG LOADED POLYMERIC MATERIALS  
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
US20090234126 Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide  
A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.
7589078 Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections  
The present invention relates to compounds according to the general formula: wherein B is or and the remaining variables are defined in the specification, and compositions comprising...
US20090221610 Compositions and Methods for Treating Cognitive Disorders  
The present invention relates to the use of inhibitors or blockers of I h (hyperpolarization-activated cationic current) channels in the treatment of cognitive disorders. In preferred aspects of...
US20090220586 PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES  
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha...
US20090220427 Drug Resistance and Methods of Reversing  
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to...
US20090215842 Method of Treating Schizophrenia Prodrome  
The present invention relates to a method of treating schizophrenia prodrome in human subjects using a NMDA glycine site agonist, a glycine transporter-1 inhibitor or mixtures thereof, optionally...
US20090215691 NOGO Receptor Antagonists  
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding...
US20090214496 BMX/ETK TYROSINE KINASE GENE THERAPY MATERIALS AND METHODS  
The present invention relates to materials and methods for the treatment of arterial diseases having impaired arteriogenesis and angiogenesis. More particularly, the invention provides materials...
US20090202533 TREATMENT AND PROPHYLAXIS OF TH2 MEDIATED DISORDERS  
The present invention provides a method for the treatment or prophylaxis of T-helper type 2 (Th2)-mediated disorders using antagonists of IL-11.
7560029 Osmotic desalination process  
An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to...
7553821 Methods for selectively modulating survivin apoptosis pathways  
The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the...
7553674 Methods of identifying compounds useful for modulating intraflagellar transport  
The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of...
US20090162347 METHODS, COMPOSITIONS, AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
7550154 Methods of treatment with drug loaded polymeric materials  
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
US20090155266 Methods and Compositions Relating to Vascular Endothelial Growth Factor and TH2 Mediated Inflammatory Diseases  
The present invention includes compositions and methods for the treatment of a Th2 mediated inflammatory disease, relating to inhibiting a VEGF. The invention further includes methods to identify...
US20090153139 Methods and Apparatus for Compensating Field Inhomogeneities in Magnetic Resonance Studies  
One aspect of the present disclosure relates to a method or determining location(s) at which at least one magnetic article is to be positioned during a magnetic resonance imaging procedure of at...
7546650 Adjustable surgical table  
A surgical table includes a horizontal patient support with a base extending therefrom and supporting the patient support at a desired height. The surgical table also includes an adjustment...
US20090149410 Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
US20090148539 Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
7541182 In vitro test to detect risk of preeclampsia  
The present invention provides methods for identifying patients at risk of developing preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients...
7538089 Anti-inflammatory compounds and uses thereof  
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...