Patents and Patent Applications from Yale University


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US20180256586 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES  
The present disclosure relates to bifunctional compounds, which find utility as modulators of FLT3 (target protein). In particular, the present disclosure is directed to bifunctional compounds,...
US20180256480 TOPICAL FORMULATION OF HYPERBRANCHED POLYMER-COATED PARTICLES  
Core-shell particles have a hydrophobic core and a shell formed of o containing hyperbranched polymers (HP). The HP can be covalently bound to the one or more materials that form the core or...
10071164 Estrogen-related receptor alpha based protac compounds and associated methods of use  
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which...
10066026 Chimeric small molecules for the recruitment of antibodies to cancer cells  
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The...
10066025 Compositions and methods for detecting, treating and preventing diseases and disorders  
The invention described herein relates to the discovery that renalase, and fragments thereof, are useful for the treatment or prevention of cardiac and renal diseases or disorders. Thus, the...
10064917 Compositions for treating pathological calcification conditions, and methods using same  
The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the...
US20180247217 TECHNIQUES OF OSCILLATOR CONTROL FOR QUANTUM INFORMATION PROCESSING AND RELATED SYSTEMS AND METHODS  
According to some aspects, a method is provided of operating a circuit quantum electrodynamics system that includes a physical qubit dispersively coupled to a quantum mechanical oscillator, the...
US20180243482 ANTI-THROMBOGENIC GRAFTS  
The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an...
US20180243226 POLYMERIC BILE ACID NANOCOMPOSITIONS TARGETING THE PANCREAS AND COLON  
Pharmaceutical composition containing poly(bile) acid (PBA) polymers for oral delivery of agent(s) show enhanced uptake by the pancreas, liver, and colon. These nanoparticles show significant...
10059672 (−)-Huperzine A processes and related compositions and methods of treatment  
The invention provides (1) processes for making substantially-pure (−) huperzine A and substantially-pure (−) huperzine A derivatives; (2) compositions useful in making substantially-pure (−)...
10059650 Systems and methods for the depolymerization of a biopolymer  
Methods for the production and isolation of a monomer from a biopolymer are described. The method includes extracting a biopolymer from a biopolymer source and depolymerizing the biopolymer into a...
10058581 Use of PHY906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome  
The present invention includes a method of using PHY906 for treating a bowel disorder including inflammatory bowel disease and irritable bowel syndrome. Particularly, the present invention...
10058580 Herbal composition PHY906 and its use in chemotherapy  
This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life...
US20180237395 (--)-HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT  
The invention provides (1) processes for making substantially-pure (−) huperzine A and substantially-pure (−) huperzine A derivatives; (2) compositions useful in making substantially-pure (−)...
10052367 Compositions and methods for treating pathological calcification and ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
10052318 Glutamate agents in the treatment of mental disorders  
Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate...
US20180230204 Humanized anti-DKK2 antibody and uses thereof  
The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor, and hence suppresses tumor formation....
10048276 Methods and kits for detecting misfolded proteins  
Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
10047420 Multi step processing method for the fabrication of complex articles made of metallic glasses  
In one embodiment, the invention provides a process for thermoplastic forming of a metallic glass. For example, in one embodiment, the invention provides a process for thermoplastic forming of a...
US20180221500 Environmentally Sensitive Compositions and Methods of Use Thereof  
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
10040867 Cell penetrating anti-guanosine antibody based therapy for cancers with Ras mutations  
It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells...
US20180216188 GENOTYPE-GUIDED DOSING OF OPIOID RECEPTOR AGONISTS  
Provided herein, in some aspects, are methods of dosing opioid receptor agonists for treatment of opioid dependence and pain management.
US20180216077 DIFFERENTIATION OF HUMAN IPS CELLS TO HUMAN ALVEOLAR TYPE II VIA DEFINITIVE ENDODERM  
The present invention relates to compositions and methods for generating populations of tissue precursor cells from pluripotent cells, and preferably induction of stem cells into definitive...
US20180216057 SYSTEM AND METHOD FOR GENERATING BIOLOGICAL TISSUE  
The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized...
10034917 Nanoparticle-mediated delivery of cytokines for maintenance of the regulatory T cell phenotype  
Compositions for delivery of growth factors needed for stable Tregs and methods of use thereof are provided. In preferred embodiments, the compositions can induce, increase, or enhance a...
10030008 Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus  
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through...
US20180201649 NOVEL CELL-PENETRATING COMPOSITIONS AND METHODS USING SAME  
The invention includes an isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell. The invention also includes a transport construct in which a...
US20180200354 Dickkopf2 (Dkk2) Inhibition Suppresses Tumor Formation  
The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor angiogenesis, and hence suppresses tumor...
US20180200336 Vehicles For Controlled Delivery of Different Pharmaceutical Agents  
A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can...
US20180200196 Modular Particulars for Immunotherapy  
Nanoparticulate compositions are disclosed. The nanoparticulate compositions typically include at least one, preferably two or more, active agent(s), one of which is an immunomodulatory compound,...
10023893 Compositions and methods for making selenocysteine containing polypeptides  
Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally...
10022341 Methods of preventing neurodegeneration of association cortex in a mammal  
The present invention provides methods of preventing and/or reducing risk of neurodegeneration of association cortex, and/or inhibiting or reversing formation of phosphorylated tau or COXIV in the...
US20180198427 WIRELESS JOSEPHSON BIFURCATION AMPLIFIER  
A wireless Josephson-junction-based amplifier is described that provides improved tunability and increased control over both a quality factor Q and participation ratio p of the amplifier. The...
US20180195042 DEVICE AND METHOD FOR OBTAINING IMMUNO-STIMULATORY ANTIGEN-PRESENTING CELLS  
The present invention relates to methods for producing immuno-stimulatory antigen-presenting cells. The present invention further relates to the use of such cells for treating patients suffering...
US20180193529 COMPOSITIONS AND METHODS FOR PROMOTING PATENCY OF VASCULAR GRAFTS  
Methods for increasing the patency of biodegradable, synthetic vascular grafts are provided. The methods include administering one or more cytokines and/or chemokines that promote outward tissue...
US20180193470 EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE  
The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to...
10017782 Immune cells modified by transient transfection of RNA  
RNA prepared by in vitro transcription using a polymerase chain reaction (PCR)-generated template can be introduced into a cell to modulate cell activity. This method is useful in...
10017761 Methods for preparing cDNA from low quantities of cells  
Methods for preparing cDNA libraries from single and low quantities of cells are disclosed. The methods are based on the principles of multi-strand displacement amplification or semi-random primed...
10016412 TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)  
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The...
US20180186785 Proteolysis Targeting Chimera Compounds and Methods of Preparing and Using Same  
The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase...
10012648 Plasma cytochrome C as a biomarker for mitochondrial toxicity during antiretroviral therapy  
The present invention relates to the discovery that measurement of the level of cytochrome c (Cyt-C) in the plasma can be used as a diagnostic signature to predict antiretroviral therapy (ART)...
US20180179601 Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation  
The present invention provides systems and methods for performing forward genetic screens in cells and methods of treating disease through inhibiting targets identified in a forward genetic screen...
US20180179183 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES  
The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In...
US20180179176 BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR  
The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are...
US20180177901 EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING  
The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies...
US20180177688 TOPICAL FORMULATION OF HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES THEREOF  
Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core...
US20180169192 Compositions and Methods for Modulating Coagulation  
The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.
9999855 Microfluidic processing of target species in ferrofluids  
Disclosed are systems, devices, methods, and other implementations, including a device to detect at least one target species in a sample, with the device including a microfluidic channel...
US20180163210 COMPOSITIONS AND METHODS FOR CONTROLLING VASCULATURE  
The invention relates to compositions and methods for reducing excessive vascular development and treat related disorders. In one aspect, the invention provides methods for treating, reducing or...
US20180162813 MIF MODULATORS  
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low...