Patents and Patent Applications from Yale University


Match Document Document Title
9790605 Iridium complexes for electrocatalysis  
Solution-phase (e.g., homogeneous) or surface-immobilized (e.g., heterogeneous) electrode-driven oxidation catalysts based on iridium coordination compounds which self-assemble upon chemical or...
9789236 Implantable heart pump controller  
The present invention provides devices, systems, and methods for control of and communication with ventricular assist devices. In certain embodiments, the invention includes an implantable...
9788985 Friction-based orthotic impedence modulation device  
The present invention relates to an impedance modulation device for an orthotic application. The device includes a high-stiffness loading spring, a low-stiffness return spring, a shaft having an...
US20170291961 MULTIVALENT FRAGMENTS OF ANTIBODY 3E10 AND METHODS OF USE THEREOF  
Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain...
9786275 System and method for anomaly detection and extraction  
The present invention relates to a system for suppressing transient interference from a signal. The system includes a modeling system, wherein the modeling system constructs a model of transient...
9782522 Compositions and methods for treating and preventing neointimal stenosis  
Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGFβ inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a...
US20170283830 COMPOSITIONS FOR ENHANCING TARGETED GENE EDITING AND METHODS OF USE THEREOF  
Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing...
US20170281588 Compositions and Methods for Treating Epithelial Cancer  
The present invention provides the eutomeric isomer of the compound of formula (I), or a salt or solvate thereof, which can be used to treat epithelial cancer in a subject. In certain embodiments,...
US20170274054 Compositions and Methods for Modulating Coagulation  
The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.
US20170274041 Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury  
Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides,...
US20170274001 Compositions and Methods for Increasing Red Blood Cells  
The invention relates generally to a composition and method for increasing the frequency, amount, or presence of red blood cells in peripheral blood. In one embodiment, the invention comprises the...
US20170273772 Assemblies And Methodologies For The Repair Of Hernias  
An assembly for the repair of a hernia. The assembly includes an elongated shaft having a first end; a first holding member at least mostly positionable in the elongated shaft and a second holding...
US20170273285 Humanized M-CSF Mice  
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a...
US20170266325 COMPOSITIONS FOR NANOCONFINEMENT INDUCED CONTRAST ENHANCEMENT AND METHODS OF MAKING AND USING THEREOF  
Multivalent CT or MR contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of CT or MR...
US20170266119 HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF  
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is...
9769399 Techniques for processing imaging data having sensor-dependent noise  
Techniques for processing imaging data contaminated by sensor-dependent noise. An imaging method is described. In the imaging method, imaging data corresponding to an imaged region and acquired by...
9764418 Joining of metallic glasses in air  
A method of joining a bulk metallic glass to a second similar or dissimilar material in an air environment. The method includes the steps of: a) removing an oxide layer on at least a portion of a...
9764109 Method of correlating brain activity  
The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner...
9758838 Compositions and methods for identifying secretory antibody-bound microbes  
The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and...
9758522 Hydrophobically tagged small molecules as inducers of protein degradation  
Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a...
US20170252414 Compositions and Methods for Treating Pathological Calcification and Ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
9750693 Liposome structures and methods of use thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the...
US20170251191 SYSTEMS, METHODS, AND COMPUTER-READABLE MEDIA FOR ULTRA-HIGH RESOLUTION 3D IMAGING OF WHOLE CELLS  
One aspect of the invention provides a method for drift correction to correct a 3D point collection dataset to compensate for drift over time. The method includes: (a) separating the 3D dataset...
US20170248611 METHOD AND PANEL FOR DETERMINING ACUTE KIDNEY INJURY  
A method for determining the risk of acute kidney injury (AKI) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of IL-6 or hFABP concentration,...
9745334 Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use  
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through...
9744219 Compositions and methods for treating pathological calcification and ossification  
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or...
9744191 Antimicrobial compositions and methods  
Disclosed are compositions and methods for antimicrobial use. The compositions contain a small antimicrobial agent and a permeabilizing agent. The antimicrobial compositions can be antifungal or...
US20170242000 Calibration of Nanostructure Sensors  
The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has...
US20170240908 COMPOSITIONS AND METHODS FOR BIOCONTAINMENT OF MICROORGANISMS  
Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic...
US20170240648 ANTI-ERBB ANTIBODIES AND METHODS OF USE THEREOF  
Provided herein are compositions, methods and uses involving antibodies that bind to ErbB, a receptor tyrosine kinase, and modulate the activity of ErbB. Also provided are uses and methods for...
9739771 Physiologic sample preparation for nanosensors  
The present invention provides a microfluidic purification chip for capturing a biomarker from a physiological solution. The present invention also provides a method of capturing and releasing a...
9738517 Mold for forming complex 3D MEMS components  
A mold structure having high-precision multi-dimensional components which includes a first oxide layer superimposed on a top of a first semiconductor substrate; a second oxide layer superimposed...
9737593 Carbon nanotube compositions and methods of use thereof  
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or...
US20170237234 A METHOD FOR GAN VERTICAL MICROCAVITY SURFACE EMITTING LASER (VCSEL)  
Structures and methods for forming highly uniform and high-porosity gallium-nitride layers with sub-100-nm pore sizes are described. Electrochemical etching of heavily-doped gallium nitride at low...
US20170233749 SITE-SPECIFIC INCORPORATION OF PHOSPHOSERINE INTO PROTEINS IN ESCHERICHIA COLI  
Nucleic acids encoding mutant elongation factor proteins (EF-Sep), phosphoseryl-tRNA synthetase (SepRS), and phosphoseryl-tRNA (tRNASep) and methods of use in site specific incorporation of...
US20170232027 NOVEL COMPOSITIONS AND METHODS USEFUL FOR TREATING OR PREVENTING LIVER DISEASES OR DISORDERS, AND PROMOTING WEIGHT LOSS  
The invention includes a method of preventing or treating a toxic liver disease or disorder, such as but not limited to non-alcoholic steatohepatitis (NASH), liver injury associated with or caused...
9732324 Anti-viral method  
The invention provides a method of reducing viral infectivity in a sample comprising contacting the sample with a earner matrix wherein lipids are attached to the carrier matrix, and wherein at...
9732138 Loss of function mutations in KCNJ10 cause SeSAME, a human syndrome with sensory, neurological, and renal deficits  
The invention includes a method of identifying a human subject at-risk of developing SeSAME syndrome. The invention also includes a method of diagnosing a human subject afflicted with SeSAME...
US20170226586 Methods for Identifying Subjects with a Genetic Risk for Developing IgA Nephropathy  
Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating...
US20170226228 Compositions and Methods to Regulate Renalase in the Treatment of Diseases and Disorders  
The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions...
US20170224617 METHODS OF TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES AND DISORDERS  
Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained...
9726592 Label-free cellular manipulation and sorting via biocompatible ferrofluids  
A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described, The device includes a microfluidic channel having a sample inlet, at least one outlet and a length...
US20170218036 INNATE IMMUNE SYSTEM MODIFICATION FOR ANTICANCER THERAPY  
The present invention relates to the discovery of a role of the nuclear receptor retinoid-related orphan receptor gamma (RORgamma) in tumor suppression. The introduction and expression of RORgamma...
US20170216416 Pigment Epithelium-Derived Factor (PEDF) and Peptide Derivatives Thereof for Use in Osteoblast Differentiation and Bone Growth  
The present invention provides compositions and methods for differentiating a stem cell into an osteoblast or osteoblast progenitor cell. In certain embodiments, the invention may be used for...
US20170216244 METHODS FOR TREATING DIABETIC NEPHROPATHY  
The present invention provides methods for treating or preventing diabetic nephropathy and its related pathologies by inhibiting podocyte Semaphorin3a (Sema3a). The invention also provides a...
9718757 System and method for separating lipid based products from biomass  
Methods and systems for the production and isolation of fatty acid methyl esters (FAMEs) from a lipid source are described. The method includes extracting a lipid from a lipid source and...
US20170209570 Carbon Nanotube Compositions and Methods of Use Thereof  
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or...
US20170209489 FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION WITH ENHANCED ACTIVITY  
The present invention relates to the discovery that a hydrated salt form of zinc exhibits enhanced activity in reducing the acidity of gastric juice in a subject in need when compared to typical...
US20170209079 NANOPATTERNED BIOSENSOR ELECTRODE FOR ENHANCED SENSOR SIGNAL AND SENSITIVITY  
An electrode structure, which can be used as a biosensor, is provided that has non-random topography located on one surface of an electrode base substrate. The non-random topography of the...
9711352 Large-area, laterally-grown epitaxial semiconductor layers  
Structures and methods for confined lateral-guided growth of a large-area semiconductor layer on an insulating layer are described. The semiconductor layer may be formed by heteroepitaxial growth...