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6642034 |
Multiple displacement amplification
Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The method is based on stand displacement replication of the nucleic acid sequences of interest by...
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6638908 |
Crystals of the large ribosomal subunit
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
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6632609 |
Unimolecular segment amplification and sequencing
Disclosed are compositions and a method for amplification of and multiplex detection of molecules of interest involving rolling circle replication. The method is useful for simultaneously detecting...
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6631329 |
Use of the crystal structure of Staphylococcus aureus isoleucyl-tRNA synthetase in antibiotic design
The present invention provides the atomic coordinates derived from high resolution x-ray diffraction of the cocrystal complex comprising mupirocin with its target enzyme, isoleucyl-tRNA synthetase...
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6630613 |
Transgenic animals and lats genes
The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats...
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6630306 |
Bioreactive allosteric polynucleotides
Polynucleotides having allosteric properties that modify a function or configuration of the polynucleotide with a chemical effector and/or physical signal are employed primarily as biosensors...
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US20030182684 |
Tobacco rattle virus vectors and related compositions and methods
The application provides, in part, vectors based on novel tobacco rattle virus replicons, as well as methods for using such vectors and transgenic plants.
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US20030175287 |
Innate immune system-directed vaccines
The present invention provides novel vaccines, methods for the production of such vaccines and methods of using such vaccines. The novel vaccines of the present invention combine both of the...
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6620926 |
Purification of oligomers
Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled...
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6620805 |
Delivery of nucleic acids by porphyrins
Efficient methods and compositions are provided for the targeted delivery of effective concentrations of compounds, including nucleic acid molecules and oligonucleotides such as EGSs, ribozymes and...
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US20030166240 |
DNA & protein binding miniature proteins
The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha...
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6610511 |
Drosophila odorant receptors
The present invention provides nucleic acids and amino acids for novel olfactory receptors as well as methods for identifying olfactory receptors. More specifically, the present invention provides...
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6610478 |
Phenotypic conversion of cells mediated by external guide sequences
Disclosed are a method and compositions for delivering nucleic acids to bacterial cells. The method does not require manipulation of the bacteria and is therefore particularly suited to delivery of...
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US20030157539 |
IRAK-M is a negative regulator of toll-like receptor signaling
Isolated nucleic acid encoding the amino acid sequence of murine IRAK-M; expression vectors comprising nucleic acid encoding IRAK-M and host cells comprising them are disclosed. IRAK-M is induced...
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6609189 |
Cycle segmented prefix circuits
The poor scalability of existing superscalar processors has been of great concern to the computer engineering community. In particular, the critical-path delays of many components in existing...
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6608386 |
Sub-nanoscale electronic devices and processes
A new class of electronic systems, wherein microelectronic semiconductor integrated circuit devices are integrated on a common substrate with molecular electronic devices.
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6607932 |
High modulation frequency light emitting device exhibiting spatial relocation of minority carriers to a non-radiative recombination region
A light emitting device providing a first part that includes a source of excess minority carriers including excess electron-hole pairs; a second part, coupled to the first part, that includes a...
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6605447 |
Methods and means of detecting nitric oxide synthase
Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide...
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US20030148359 |
Saxitoxin detection and assay method
Tagged saxiphilin and tagged fragments thereof that bind saxitoxin and saxitoxin derivatives, methods of producing tagged saxiphilin and tagged fragments and methods of detecting and measuring...
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6579716 |
Better emergence characteristics and improved seedling growth under low-light environments
This invention relates to seedlings which demonstrate better emergence characteristics when grown in darkness and improved seedling growth when grown under low-light levels. More specifically, the...
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6576448 |
Methods for selectively isolating DNA using rolling circle amplification
DNA containing nucleotide base mispairs can be isolated using a modified rolling circle amplification procedure. Specific Y-shaped adapters permit the selective circularization of these fragments...
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6573067 |
Nucleic acid encoding sodium channels in dorsal root ganglia
A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na+ current through the...
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6569648 |
Method for selection of insertion mutations
The present invention provides a highly-efficient method for the selection and identification of insertional mutants. In the technique, a non-selective amplification is used to isolate a plurality...
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6566030 |
Methods and compositions for imaging acids in chemically amplified photoresists using pH-dependent fluorophores
A method of imaging acids in chemically amplified photoresists involves exposing to radiation a chemically amplified photoresist comprising a pH-dependent fluorophore. Upon exposure to radiation,...
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6562989 |
Catalyst for aromatic C—O, C—N, and C—C bond formation
The present invention is directed to a transition metal catalyst, comprising a Group 8 metal and a ligand having the structure wherein R, R′ and R″ are organic groups having 1-15 carbon atoms, n=1...
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6559285 |
Nucleotide and protein sequences of lats genes and methods based thereon
The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats...
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6558954 |
Phenotypic conversion of cells mediated by external guide sequences
Disclosed are a method and compositions for delivering nucleic acids to bacterial cells. The method does not require manipulation of the bacteria and is therefore particularly suited to delivery of...
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6551775 |
Method to diagnose and treat pathological conditions resulting from deficient ion transport such as pseudohypoaldosteronism type-1
The present invention is based, in part, on the identification of the roles of the human ATP-sensitive K+ channel, ENaC in causing pathological condition associated with abnormal ion transport,...
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6548259 |
Multiparametric fluorescence in situ hybridization
The invention relates to a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said...
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6541478 |
Smoking cessation treatments using naltrexone and related compounds
Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
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6509162 |
Methods for selectively modulating survivin apoptosis pathways
The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the...
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6506563 |
Multiparametric fluorescence in situ hybridization
The invention relates to a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said...
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6506562 |
Allele frequency differences method for phenotype cloning
A general method is described for screening cDNAs, genes or genome segments to directly isolate and characterize sequences associated with particular phenotypes. In the case of the human genome, a...
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6503888 |
AAV-mediated delivery of DNA to cells of the nervous system
The invention relates to a method of delivering exogenous DNA to a target cell of the mammalian central nervous system using an adeno-associated virus (AAV)-derived vector. Also included in the...
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6492131 |
Class I-type lysyl-TRNA synthetase
A protein with canonical lysyl-tRNA synthetase activity was purified from Methanococcus maripaludis, cloned, and sequenced. The predicted amino acid sequence of the enzyme indicated a novel class I...
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6485935 |
Structure of the ankyrin binding domain of a α-Na, K-ATPase
The present invention provides a polypeptide of 26 amino acid residues that comprises the minimal ankyrin binding (MAB) domain. The MAB domain is responsible for the interactions between a...
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6482603 |
Method of detecting drug-receptor and protein-protein interactions
The present invention relates to methods for detecting interactions between two proteins as well as detecting the modulation of those interactions. The present invention is based upon the discovery...
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6476012 |
Estradiol-16α-carboxylic acid esters as locally active estrogens
The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16α-carboxylic ...
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6475482 |
Genetically modified tumor-targeted bacteria with reduce virulence
The invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention further relates to the...
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6466894 |
Device, method, and medium for predicting a probability of an occurrence of a data
In a Bayes mixture probability density calculator for calculating Bayes mixture probability density which reduces a logarithmic loss A modified Bayes mixture probability density is calculated by...
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6451937 |
Selective, catalytic, thermal functionalization of primary C-H hydrocarbon bonds
A process for the catalytic coupling of aliphatic or alkyl branched alicyclic hydrocarbons with a functionalizing reagent under thermal conditions to selectively functionalize the hydrocarbon at...
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6448582 |
High modulation frequency light emitting device exhibiting spatial relocation of minority carriers to a non-radiative recombination region
A light emitting device is constructed so as to provide a first part that includes a source of excess minority carriers including excess electron-hole pairs; a second part, coupled to the first...
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6447784 |
Genetically modified tumor-targeted bacteria with reduced virulence
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also...
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6444469 |
Methods for altering the rate of plant development and plants obtained therefrom
The present invention is based on the unexpected observation that DNA methylation, particularly at cytosine residues, regulates the rate of development of a plant. Based on this observation, the...
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6436948 |
Method for the treatment of psoriasis and genital warts
The present invention relates to the use of prodrug forms of (−)-(2S,4S)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)cytosine to treat psoriasis, genital warts and other hyperproliferative keratinocyte d...
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6436650 |
Activated forms of notch and methods based thereon
The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch...
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6429018 |
Prenatal screening for Down's syndrome using hyperglycosylated gonadotropin
A prenatal screening method for Down's syndrome involves assaying for hyperglycosylated gonadotropin in biological test samples such as urine, plasma or serum obtained from pregnant women....
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6420377 |
Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I: TI—L—TII (I)wherein:TI is a top...
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6410225 |
Purification of oligomers
Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled...
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6403319 |
Analysis of sequence tags with hairpin primers
Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method involves amplifying nucleic acid fragments of interest...
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