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5039797 |
2'-O-(4-benzoyl)benzoyl nucleoside cyclic monophosphate
The invention is a 2'-O-(4-benzoyl)benzoyl nucleoside 3', 5'-cyclic monophosphate of formula (I) ##STR1## wherein R' is guanine or adenine. Also disclosed are topical pharmaceutical compositions...
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5012815 |
Dynamic spectral phonocardiograph
A system of generating a spectral phonocardiogram which summarizes time-dependent changes in the heart sounds throughout the heart cycle. The system is based on the projection of spectral surfaces...
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4981138 |
Endoscopic fiberoptic fluorescence spectrometer
A method of detecting pre-malignant lesions in the gastrointestinal tract comprises positioning an opitcal fiber in a patient's gastrointestinal tract and transmitting ultraviolet laser light...
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4978655 |
Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
This invention relates to the use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with a retrovirus.
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4970237 |
Use of clomiphene to increase bone mass in premenopausal women
This invention relates to the use of clomiphene in preventing osteoporosis in humans and treating human patients experiencing osteoporosis.
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4962114 |
1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity
Compounds of the formula: ##STR1## wherein R1 is a lower alkyl of 1-6 carbon atoms, benzyl, phenyl or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms,...
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4948590 |
Avidin or streptavidin conjugated liposomes
A liposome conjugated with a streptavidin compound, wherein carboxyl residues of the streptavidin are coupled to phospholipid amino groups of the liposome. The resultant streptavidin-conjugated...
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4935361 |
Cloning and expression of T4 DNA polymerase
The DNA sequence encoding T4 DNA polymerase (gene 43 of T4 phase) has been successfully cloned, thereby providing a convenient source of this enzyme. The method involves the production of a gene 43...
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4932044 |
Tissue analyzer
A system is disclosed for counting particles/cells within a counting box of precisely known volume that is completely inside a transparent section or sample. The box has a chosen height with...
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4929751 |
Vinyl tricarbonyl compounds and methods of making the same
A vinyl tricarbonyl compound of the formula ##STR1## or its monohydrate of the formula ##STR2## wherein R1 is a hydrogen, halogen, unsubstituted or substituted C1 to C30 alkyl, unsubstituted or...
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4920484 |
Multiprocessor/memory interconnection network wherein messages sent through the network to the same memory are combined
A method and apparatus is described for enabling efficient, bilateral communications in a network connecting a plurality of target address modules and a plurality of source address generators. The...
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4894547 |
Optical method and apparatus for detecting and measuring aging, photoaging, dermal disease and pigmentation in skin
A method and apparatus for inducing fluorescence in human skin, in vivo, and for evaluating certain skin characteristics from the spectral intensity of induced fluorescence. The energy of a...
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4892887 |
N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
Compounds of the formula ##STR1## where R is methyl or 2-chloroethyl, and R1 and R2 are each an aromatic hydrocarbon, ring substituted aromatic hydrocarbon moiety, or an alkyl moiety. The compounds...
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4888274 |
RecA nucleoprotein filament and methods
A stable, single-stranded nucleoprotein filament adapted to complex specifically and stably with a target duplex DNA having a selected base sequence. The filament is composed of a single-stranded...
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4880983 |
High pressure xenon ionization detector
A method is provided for detecting ionization comprising allowing particles that cause ionization to contact high pressure xenon maintained at or near its critical point and measuring the amount of...
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4874488 |
Photochemical dimerization and functionalization of alkanes, ethers, primary and secondary alcohols, phosphine oxides and silanes
The space-time yield and/or the selectivity of the photochemical dimerization of alkanes, ethers, primary and secondary alcohols, phosphine oxides and primary, secondary and tertiary silanes with...
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4868880 |
Method and device for compensating for partial hearing loss
A method and device for compensating for partial hearing loss by converting a time domain signal corresponding to a sound into a series of digital component values in the frequency domain,...
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4868286 |
Translation inhibiting peptide
A peptide that causes a suppression in protein synthesis by halting the translation of mRNA into protein, the peptide having a Stokes radius of less than 16 Angstroms, a molecular weight,...
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4855931 |
Stochastic method for finding molecular conformations
This is a stochastic method for determining the likely conformations of a molecule by starting with an initial molecular structure along with given atomic coordinate positions and defined bonds...
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4849563 |
Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity
Compounds of the formula: ##STR1## wherein R1 s an alkyl of 1-6 carbon atoms, benzyl, phenyl, or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino,...
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4847300 |
Use of alpha-2I selective adrenergic receptor agonists in memory enhancement
Disclosed is a method of treating memory disorders and cognitive decline, e.g., age-related cognitive decline, in a primate by administering thereto a therapeutically effective amount of an alpha-2...
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4835255 |
T-cell membrane protein
A 16.7 kilodalton membrane protein which is produced in mature, but no early-stage, T cells has been discovered. The protein has four distinct amphipathic domains, each having an amino acid...
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4820736 |
Use of clomiphene to predict fertility in a human female
The invention relates to the use of clomiphene and its citrate salt in predicting fertility in a human female.
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4818770 |
Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis
DL-alpha-Difluoromethylornithine (DFMO), an inhibitor of the polyamine biosynthetic enzyme ornithine decarboxylase (ODCase; EC 4.1.1.17), strongly retards the growth of several species of...
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4806531 |
2,3-bis(aziridinyl)-1,4-naphthoquinone sulfonate derivatives having antineoplastic activity
The compounds of the formula: ##STR1## wherein R is selected from the group consisting of: (a) a substituent having the formula: ##STR2## wherein R1, R2 and R3 are each independently selected from...
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4785806 |
Laser ablation process and apparatus
A process and apparatus for ablating atherosclerotic or tumorous tissues is disclosed. Optical fibers direct low power light energy at a section of tissue to be ablated to cause the section to...
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4785014 |
Use of clonidine in memory enhancement
Disclosed is a method of treating cognitive decline in a normal aged primate by administering thereto a therapeutically effective amount of 2-[(2,6-dichlorophenyl)-amino]-2-imidazoline or a...
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4780420 |
Progesterone receptor ligands
Radiodinated and non-radiodinated 16α-iodo- and 17α-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays.
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4738928 |
Method for cloning genes
A method is provided for isolating and identifying a recombinant clone having a DNA segment therein coding for at least one desired heterologous polypeptide, at least a short amino acid sequence of...
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4725342 |
Photochemical dimerization and functionalization of alkanes, ethers, primary alcohols and silanes
The space-time yield and/or the selectivity of the photochemical dimerization of alkanes, ethers, primary alcohols and tertiary silanes with Hg and U.V. light is enhanced by refluxing the substrate...
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4722999 |
Cyclophilin
Homogeneous cyclophilin, a soluble binding protein, having a specific binding activity of above 50 ug cyclosporin A per mg protein and a molecular weight of about 17,600 daltons, reversibly binds...
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4711955 |
Modified nucleotides and methods of preparing and using same
Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C1' -position of the sugar moiety, provided that when B is...
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4710566 |
Purification of the messenger RNA cap-binding protein
The synthesis of a new affinity medium, the p-aminophenyl-γ-ester of 7-methylguanosine-5'-triphosphate coupled to Sepharose, for use in affinity chromatography is claimed. An improved method in ...
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4710492 |
3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients...
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4710465 |
Junction-fragment DNA probes and probe clusters
A junction-fragment DNA probe, a DNA probe cluster, and methods of preparing and using the probe and cluster to study gene localization and organization. The probe includes first and second gene...
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4695449 |
Composition and method for treatment of melanomas
A composition and method for the treatment of melanomas in human beings wherein the composition comprises at least one O-phosphorylated derivative of 3-(3,4-dihydroxy)phenylalanine.
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4687732 |
Visualization polymers and their application to diagnostic medicine
A method for detecting a minute quantity of an inorganic or organic target molecule by combining it with a composition of a detecting agent for the target molecule which carries, by direct or...
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4684747 |
N,N'-bis(sulfonyl)hydrazines having antineoplastic activity
Compounds of the formula ##STR1## where R is methyl or 2-chloroethyl, and R1 and R2 are each an aromatic hydrocarbon, ring substituted aromatic hydrocarbon moiety, or an alkyl moiety. The compounds...
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4678995 |
Apparatus and method for determining the presence of substances in a sample by NMR and producing an NMR image thereof
An apparatus and method of unambiguously determining the presence of specific substances in a sample by NMR and then obtaining a high resolution NMR image of these substances. The sample is placed...
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4671959 |
Method of causing the reduction of physiological and/or subjective reactivity to stress in humans being subjected to stress conditions
Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an...
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4670463 |
Method of causing the reduction of physiological and/or subjective reactivity to stress in humans being subjected to stress conditions
Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an...
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4670264 |
Method of causing the reduction of physiological and/or subjective reactivity to stress in humans being subjected to stress conditions
Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an...
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4666903 |
Novel use of benzodiazepine antagonist
Benzodiazepine antagonists are used to regenerate the sensitivity response to and prevent tolerance of benzodiazepine which otherwise develops during chronic benzodiazepine exposure. The...
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4639532 |
Process for preparing synthetic periplanone-B
Disclosed is an improved process for synthesizing periplanone-B, the sex attractant and sex excitant pheromone of the American cockroach, Periplaneta americana.
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4618484 |
Composition and method for treatment of melanomas
A composition and method for the treatment of melanomas in human beings wherein the composition comprises at least one O-phosphorylated derivative of 3-(3,4-dihydroxy)phenylalanine.
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4612477 |
Triggering device for a vacuum arc in a plasma centrifuge
The present invention is directed to an apparatus for producing a vacuum arc in a plasma centrifuge. The apparatus comprises a cathode of a material from which the vacuum arc is formed and a...
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4601828 |
Transfer of macromolecules from a chromatographic substrate to an immobilizing matrix
The method of transfer of macromolecules such as nucleic acid and proteins from a chromatographic substrate to an immobilizing matrix uses as the immobilizing matrix, a charge modified microporous...
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4542293 |
Process and apparatus for changing the energy of charged particles contained in a gaseous medium
A method of changing the energy of charged particles contained in a gas comprises allowing the gas to flow into a region of reduced pressure through a tube like member so that viscous forces...
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4541910 |
Method for electroblotting macromolecules from a chromatographic gel
An improved method of electroblotting macromolecules from a chromatographic gel is claimed. The method comprises a design for wire electrode arrays that are capable of generating either highly...
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4531056 |
Method and apparatus for the mass spectrometric analysis of solutions
An electrospray ion source for a mass spectrometer capable of generating ions from samples dissolved in a solution comprises a capillary tube through which the said solution is pumped into a first...
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