Patents and Patent Applications from Wayne State University


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US20170348414 NOVEL SYNTHETIC ANTICANCER, ANTIFUNGAL, AND ANTIBACTERIAL VACCINES  
Described herein are compounds for use in vaccine compositions which contain natural or synthetic carbohydrate antigens. Such vaccines may be highly immunologically active due to the conjugation...
US20170334889 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE  
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is...
9824872 Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry  
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure...
9822446 Thermally stable volatile precursors  
A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is...
9816076 Protein-induced pluripotent cell technology and uses thereof  
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction...
US20170319669 METHOD OF ENHANCING VIRAL-MEDIATED GENE DELIVERY  
The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.
9797906 Detectors of serum biomarkers for predicting ovarian cancer recurrence  
Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at...
US20170298453 SYSTEMS AND METHODS TO DETECT STEM CELL STRESS AND USES THEREOF  
Systems and methods (S/M) to detect stress in stem cells are described. The S/M, including modified stem cells, assays and high throughput screens, can be used to identify compounds or other...
US20170296615 METHOD AND COMPOSITION FOR A PROTEIN TRANSDUCTION TECHNOLOGY AND ITS APPLICATIONS  
A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection...
9790435 Green diesel production from hydrothermal catalytic decarboxylation on a supported Pd—Co catalyst  
Materials and methods for converting brown grease to useful diesel fuel are described. One material is a palladium catalyst on a silicon/carbon support. A method comprises flowing fresh hydrogen...
US20170285107 BATTERY STATE OF CHARGE ESTIMATOR  
A battery monitoring device includes a first coil positioned within a cell of a battery, a second coil positioned to be magnetically coupled to the first coil through active material that is...
9778105 Static interferometer with step-style reflective element  
An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a...
9776177 Bimetal catalysts  
A catalyst comprises a carbide or nitride of a metal and a promoter element. The metal is selected from the group consisting of Mo, W, Co, Fe, Rh or Mn, and the promoter element is selected from...
US20170273924 VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT  
Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. The valproate compositions can be formulated as topical antifungals.
US20170260190 SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE  
This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts,...
9758866 Synthesis and characterization of first row transition metal complexes containing α-imino alkoxides as precursors for deposition of metal films  
A compound that is useful for forming a metal by reaction with a reducing agent is described by formula (I): wherein M is a metal selected from Groups 2 through 12 of the Periodic Table; andR1,...
US20170252376 NUCLEIC ACID CONSTRUCTS INCLUDING A TXNIP PROMOTER FOR THE TREATMENT OF DISEASE  
Nucleic acids for the treatment of diseases are described. The nucleic acids include a thioredoxin-interacting protein (TXNIP) promoter and a gene that encodes a therapeutic protein or an...
US20170248599 METHODS AND COMPOSITIONS RELATING TO ASSAYS OF FETAL EXTRAVILLOUS TROPHOBLAST CELLS  
Methods of isolating and assaying fetal extravillous trophoblast cells, including assays of RNA of the fetal extravillous trophoblast cells according to aspects of the disclosure include obtaining...
US20170246238 NEUROKININ 1 RECEPTOR AGONIST MEDIATED PROTECTION OF THE EYE  
Neurokinin 1 receptor (NK1R) agonist mediated protection of the eye is described. The protection can reduce dry eye and ocular infections, particularly in individuals with reduced NK1R activity.
US20170242021 SYSTEMS AND METHODS TO IDENTIFY AND TREAT SUBJECTS AT RISK FOR OBSTETRICAL COMPLICATIONS  
Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are...
9732067 Compounds and methods for activating the apoptotic arm of the unfolded protein response  
N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is...
9730981 Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids  
Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in...
9730888 Method of enhancing delivery of therapeutic compounds to the eye  
The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.
US20170217903 ANTICANCER DRUGS INCLUDING THE CHEMICAL STRUCTURES OF AN ANDROGEN RECEPTOR LIGAND AND A HISTONE DEACETYLASE INHIBITOR  
A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity...
US20170216445 CXCR4 INHIBITING CARRIERS FOR NUCLEIC ACID DELIVERY  
The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be...
US20170216434 COMPOSITIONS AND METHODS FOR TREATMENT OF SICKLE CELL DISEASE  
This invention relates to methods of treating sickle cell disease with VLA-4 antagonists and methods for evaluating the responsiveness of patients having sickle cell disease to treatment with...
US20170216200 DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS  
Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular...
US20170214246 BALANCED CONTROL STRATEGIES FOR INTERCONNECTED HETEROGENEOUS BATTERY SYSTEMS IN SMART GRID APPLICATIONS  
A battery network includes a plurality of heterogeneous batteries coupled to at least one energy source and one energy load, a plurality of switches coupled to the heterogeneous batteries, and the...
US20170213714 SYSTEMS AND METHODS FOR HIGH THROUGHPUT SOLVENT ASSISTED IONIZATION INLET FOR MASS SPECTROMETRY  
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure...
9714464 Precursors for atomic layer deposition  
Atomic layer deposition (ALD) and chemical vapor deposition (CVD) precursors that are useful for forming metal-containing films are provided. These compounds include triazapentadienyl, α-imino...
9706646 Origami enabled manufacturing systems and methods  
An origami enabled manufacturing system. The system uses origami design principles to create functional materials, structures, devices and/or systems having an adjustable size and/or shape. An...
9696315 Method and composition for a protein transduction technology and its applications  
A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection...
US20170183649 METHOD FOR IDENTIFYING A SUBPOPULATION OF MAMMALIAN CELLS WITH DISTINCTIVE RIBOSOME TRANSLATION PROFILES  
The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates...
9677110 Methods for the identification of antibiotics that are not susceptible to antibiotic resistance in pseudomonas aeruginosa  
The “instant evolution” system was initially developed in E. coli, primarily because of the ease with which this organism can be genetically manipulated. Because many of the functionally important...
US20170148621 SYSTEM AND METHOD FOR IONIZATION OF MOLECULES FOR MASS SPECTROMETRY AND ION MOBILITY SPECTROMETRY  
An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second...
9655982 Formation and uses of europium complexes  
The present invention provides a method of forming an oxidatively-stable aqueous Eu(II) complex by synthesizing ligands that coordinate to large, soft, electron rich metals like Eu(II). The...
9655968 Baclofen solution for low-volume therapeutic delivery  
A high concentration baclofen solution is provided suitable for therapeutic use in a medical setting. A high concentration solution of baclofen in multivalent physiological ion solution such as...
9650384 Substituted pyrimidine compounds and methods of use and manufacture  
This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts,...
9649381 Transporter protein-coupled nanodevices for targeted drug delivery  
A tripartite nanodevice comprising a targeting portion, a carrier portion, and at least one molecule to be delivered is provided. In particular, a gold nanoparticle linked to a targeting protein...
US20170121410 COMPOSITIONS AND METHODS TO TREAT SOLID TUMORS  
Compositions and methods that utilize anti-CD11b antibodies, anti-CD18 antibodies, anti-myeloperoxidase (MPO) antibodies, anti-integrin αV antibodies, anti-integrin β1 antibodies, Abciximab,...
US20170114066 Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same  
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These...
US20170112909 HER2 ANTIGENIC POLYPEPTIDE COMPOSITIONS, AND METHODS FOR THEIR USE IN TREATMENT AND PREVENTION OF CARCINOMAS  
Antigenic polypeptides of the growth factor receptor HER2, for breaking the tolerance of a host against self HER2. The antigenic polypeptides include HER2 polypeptides with single amino acid...
9630183 Electrowetting on dielectric using graphene  
An electrowetting device and a method of electrowetting may be provided. An electrode may be provided. The electrode has a graphene layer having a first side and a second side that opposes the...
US20170109563 PALM VEIN-BASED LOW-COST MOBILE IDENTIFICATION SYSTEM FOR A WIDE AGE RANGE  
A system includes an infrared camera, an infrared light source, and a processor. The processor is programmed to receive, from the infrared camera, an image of a hand illuminated using the infrared...
US20170107253 NEUROPROTECTIVE COMPOSITION AND METHOD OF USE  
A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines, and further comprising 1 or more terminal cysteines. The composition is administered...
US20170106007 COMPOSITIONS AND METHODS RELATING TO TREATMENT OF INFECTION  
Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the...
9610460 Light therapy treatment  
An exemplary method includes selecting at least one light source configured to generate light at a particular wavelength and applying the light to tissue following an ischemic event. Applying the...
9598441 Therapeutic compounds and methods  
The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of...
9593138 Nitrile-containing enzyme inhibitors and ruthenium complexes thereof  
The invention provides nitrile-containing protease inhibitors caged to ruthenium compounds. The nitrile-caged ruthenium compounds provide inactivated inhibitors that can be delivered to surface or...
US20170067009 CELL CULTURE DEVICES FOR BIOMIMETIC AND PATHOMIMETIC CELL CULTURES  
Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port...