Patents and Patent Applications from Wayne State University


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10076574 Methods, systems and compositions relating to cell conversion via protein-induced in-vivo cell reprogramming  
Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the...
10071261 Light therapy treatment  
A light therapy method, comprising identifying a pathological condition in a patient, selecting at least one light wavelength based on the identified pathological condition, and applying one or a...
10066278 Development of nanostructure austempered ductile iron with dual phase microstructure  
A method for forming an austempered iron composition with a nanoscale microstructure includes a step of heating an iron-carbon-silicon alloy with silicon to a first temperature that is lower than...
US20180243363 NEUROKININ 1 RECEPTOR AGONIST MEDIATED PROTECTION OF THE EYE  
Neurokinin 1 receptor (NK1R) agonist mediated protection of the eye is described. The protection can reduce dry eye and ocular infections, particularly in individuals with reduced NK1R activity.
US20180243341 Methods and Compositions for Cells Expressing a Chimeric Intracellular Signaling Molecule  
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and...
US20180236135 METHODS AND COMPOSITIONS RELATING TO BIOCOMPATIBLE IMPLANTS  
Biocompatible hydrogel compositions according to aspects of the present invention are provided wherein the biocompatible hydrogel composition is or includes a physical hydrogel, a chemical...
10054067 Using ion current signal for engine performance and emissions measuring techniques and method for doing the same  
A system and method is provided for the use of the ion current signal characteristics for onboard cycle-by-cycle, cylinder-by-cylinder measurement. The system may also control the engine operating...
10052406 Method of making water soluble injectable calcium polyphosphate gels  
The present invention describes an injectable calcium polyphosphate (CPP) gel with dense structure, which can be applied as injectable bone void filler in medical field, such as orthopedic and...
US20180233742 ELECTROCATALYSIS OF LITHIUM POLYSULFIDES: CURRENT COLLECTORS AS ELECTRODES IN LI/S BATTERY CONFIGURATION  
This disclosure describes a new method and device that lead to improved performance (in the areas of energy density, power density, and cycle life) of any sulfur or selenide based including their...
US20180230592 6-MEMBERED CYCLIC DIENES AS STRONGLY REDUCING PRECURSORS FOR THE GROWTH OF ELEMENT FILMS BY VAPOR PHASE DEPOSITION  
A method for reducing an atom to a reduced oxidation state includes a step of providing a vapor of a first compound having an atom in an oxidized state. A vapor of a reducing agent is provided....
US20180222869 ANTICANCER DRUGS INCLUDING THE CHEMICAL STRUCTURES OF AN ANDROGEN RECEPTOR LIGAND AND A HISTONE DEACETYLASE INHIBITOR  
A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity...
US20180221400 COMPOSITIONS AND METHODS RELATING TO GALECTIN DETECTION  
Compositions and methods for detection and assessment of galectins are provided by the present invention, including a labeled compositions, pharmaceutical composition including a labeled...
10040822 Neuroprotective composition and method of use  
A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines (SEQ ID NO: 1), and further comprising 1 or more terminal cysteines. The composition...
US20180214513 Restoration of Visual Responses by In Vivo Delivery of Rhodopsin Nucleic Acids  
Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in...
US20180214119 ULTRASOUND AND PHOTOACOUSTIC SYSTEMS AND METHODS FOR FETAL BRAIN ASSESSMENT DURING DELIVERY  
Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a...
US20180176933 MULTISCALE APPROACH TO PREDICTABLE WIRELESS NETWORKING  
A distributed sensing and control network includes a plurality of sensing/control nodes, each of the sensing/control nodes includes a sensor, a local controller, a local memory and a wireless...
US20180172503 A CASCADED GAPPED CANTILEVER FOR LOW-FREQUENCY VIBRATION SENSING  
This disclosure describes a sensor for detecting vibrations, particularly low-frequency vibrations. The sensor is of a cascaded gapped cantilever construction and may include a single sensing beam...
10000498 Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same  
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These...
9982344 Thermally stable volatile precursors  
A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is...
US20180132458 TRANSGENIC ANIMAL MODELS FOR CYSTIC FIBROSIS  
This disclosure relates to transgenic rabbit models of cystic fibrosis, and methods of using these rabbits and their derivatives.
9968689 AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells  
Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells...
US20180128776 ELECTROCHEMICAL DEPOSITION OF NANOWIRES ON NANOPARTICLES, LITHOGRAPHICAL PATTERNS AND ELECTRONIC DEVICES AND THEIR USE AS CHEMICAL SENSORS  
Materials and methods for generating nanowires are described. Krogmann salt potassium tetracyanoplatinate sesquihydrate (K(def)TCP) nanowires are synthesized as interconnects on metal lithographic...
US20180127725 PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY AND USES THEREOF  
A method of generating protein-induced pluripotent stem cells by delivering bacterial!y expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction...
9963433 Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor  
A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity...
US20180110726 COMPOSITIONS AND METHODS TO PROMOTE WOUND HEALING  
The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1B) receptor antagonist (IL-1Ra), such as anakinra.
9951741 Predictive correction in internal combustion engines  
A method and system for reducing cycle to cycle variation of an engine is provided. The system may determine fuel injection characteristics and predict a gas burning rate or flame speed based on...
9951521 Self-confining ceramic articles using advanced material reinforcements and method of manufacture  
A self-confining structural article includes a ceramic matrix with a reinforcement member disposed within the ceramic matrix. The reinforcement member is continuous, and has a mesh with holes not...
US20180106810 DETECTORS OF SERUM BIOMARKERS FOR PREDICTING OVARIAN CANCER RECURRENCE  
Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at...
9945812 Simultaneous ion sensing and gas sampling in combustion engine cylinders and other combustion systems  
A system and method is provided for simultaneous ion current sensing and gas analysis. The system acquires an ion current signal and analyzes the composition of a corresponding gas sample.
US20180078199 DETECTION OF SLEEP DISORDERED BREATHING USING CARDIAC AUTONOMIC RESPONSES  
A memory stores R-R interval (RRI) data collected from a patient over a time interval and oxygen saturation (SaO2) data collected from the patient over the time interval. A processor is programmed...
US20180074180 ULTRAFAST TARGET DETECTION BASED ON MICROWAVE METAMATERIALS  
A system (100) for locating an object (114) includes a signal source (102) that generates a wideband signal (104) that includes a continuously variable frequency from a first frequency to a second...
US20180068577 AUGMENTED REALITY SYSTEM AND METHOD FOR EXPOSURE THERAPY AND MOTOR SKILLS TRAINING  
An exemplary system may include an augmented reality device with a user interface, a processor and memory having a program communicatively connected to the processor. A transceiver may be...
US20180064640 Method of Enhancing Delivery of Therapeutic Compounds to the Eye  
The invention provides methods for enhancing the delivery of therapeutic compounds to the eye of a subject by administering plasmin or derivatives thereof and the therapeutic compounds to the eye.
9911974 Composite anode for lithium ion batteries  
A composite anode for a lithium-ion battery is manufactured from silicon nanoparticles having diameters mostly under 10 nm; providing an oxide layer on the silicon nanoparticles; dispersing the...
US20180057448 Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8 selectivity  
A compound having formula I for histone deacetylase inhibition is provided: or a pharmaceutically acceptable salt or hydrate thereof wherein R is alkyl, C6-18 aryl, C5-18 heteroaryl, C8-22...
US20180055910 METHOD OF PREVENTION AND INHIBITION OF PRETERM LABOR  
Methods for preventing and/or inhibiting preterm labor in a pregnant subject, such as a human subject, are disclosed according to the invention including administering a therapeutically effective...
US20180037865 METHODS AND COMPOSITIONS RELATING TO TREATMENT OF NERVOUS SYSTEM INJURIES  
Compositions are provided according to aspects of the present invention which include: a plurality of longitudinally extending fibers, each of the fibers having a longitudinal axis, wherein the...
US20180031565 DETECTORS OF SERUM BIOMARKERS FOR PREDICTING OVARIAN CANCER RECURRENCE  
Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at...
US20180028608 COMPOSITIONS AND METHODS TO DIAGNOSE DIABETES AND/OR TO TREAT NEGATIVE EFFECTS OF DIABETES  
The present disclosure describes a genome-wide transcriptional analysis of differentially expressed genes in diabetic, non-diabetic, normal and wounded tissue. The analysis allowed development of...
US20180021315 METHODS OF TREATING HEARING DISORDERS  
The present disclosure provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in...
US20180015198 METHOD OF MAKING INJECTABLE CEMENTS  
A discovery of the conversion of amorphous calcium polyphosphate (ACPP) or/and other polyphosphate salts with various type of calcium phosphate to new calcium phosphate product (i.e. dicalcium...
US20180012745 MASS SPECTROMETRY USING LASERSPRAY IONIZATION  
Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis...
US20170363612 COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISORDERS  
Methods and compositions for drug discovery, analysis and treatment of a proliferative disorder characterized by abnormal cells in a mammalian subject are provided according to aspects of the...
US20170356043 ACTIVITY-DEPENDENT GENE PAIRS AS THERAPEUTIC TARGETS AND METHODS AND DEVICES TO IDENTIFY THE SAME  
Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same are provided. The methods and devices allow transcriptome-wide analysis of regulatory long...
US20170348414 NOVEL SYNTHETIC ANTICANCER, ANTIFUNGAL, AND ANTIBACTERIAL VACCINES  
Described herein are compounds for use in vaccine compositions which contain natural or synthetic carbohydrate antigens. Such vaccines may be highly immunologically active due to the conjugation...
US20170334889 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE  
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is...
9824872 Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry  
A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure...
9822446 Thermally stable volatile precursors  
A method of forming a thin film on a substrate which includes a step of contacting a surface with a precursor compound having a transition metal and one or more alkyl-1,3-diazabutadiene ligands is...
9816076 Protein-induced pluripotent cell technology and uses thereof  
A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction...
US20170319669 METHOD OF ENHANCING VIRAL-MEDIATED GENE DELIVERY  
The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.