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8183379 |
Antitumor agents
The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides...
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US20120121589 |
MODIFIED EGFR ECTODOMAIN
A protein that attenuates EGFR and/or EGFR family members comprises a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a...
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8178659 |
Targets for the identification of antibiotics that are not susceptible to antibiotic resistance
To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required...
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US20120108815 |
BIFUNCTIONAL/POLYFUNCTIONAL DOPAMINE D2/D3 AGONIST AS NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an...
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US20120107828 |
METHOD FOR IDENTIFYING A SUBPOPULATION OF MAMMALIAN CELLS WITH DISTINCTIVE RIBOSOME TRANSLATION PROFILES
The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates...
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8168398 |
Asbestos exposure, pleural mesothelioma, and osteopontin levels
The present invention provides diagnostic methods based on levels of osteopontin.
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US20120096631 |
OMNI-DIRECTIONAL ANGULAR ACCERATION REDUCTION FOR PROTECTIVE HEADGEAR
Protective headgear includes an outer shell rotatable relative to an inner shell via a thin layer of elastically and/or plastically yielding material disposed between and secured to the inner and...
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8163946 |
Methods and catalysts for making biodiesel from the transesterification and esterification of unrefined oils
A method of forming a biodiesel product and a heterogeneous catalyst system used to form said product that has a high tolerance for the presence of water and free fatty acids (FFA) in the oil...
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US20120095117 |
GALECTIN-3 nsSNP MARKER FOR CANCER
A diagnostic biomarker including a mechanism for determining a patient's propensity to develop cancer. A diagnostic kit for determining a patient's propensity to develop cancer. A method of...
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US20120093718 |
LIPOSOMAL NANOPARTICLES AND OTHER FORMULATIONS OF FENRETINIDE FOR USE IN THERAPY AND DRUG DELIVERY
Formulations of neutral retinoids, in particular fenretinide (HPR) in the form of lipid nanoparticles, solid dipersions and emulsions are disclosed. These compositions are used to treat diseases...
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US20120085903 |
MASS SPECTOMETRY USING LASERSPRAY IONIZATION
Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis...
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8148577 |
Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors...
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8148564 |
Compounds for forming metal nitrides
Nitride forming precursors are heated to form a metal nitride on a substrate. In some variations, the precursors are contacted with the substrate which has previously been heated to a sufficient...
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US20120058270 |
THERMALLY STABLE VOLATILE FILM PRECURSORS
A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an...
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8122761 |
Biosensor based on polymer cantilevers
A microcantilever sensor includes a supporting substrate, a cantilever spring element at least partially disposed over the support substrate, a probe layer disposed over the first side of the...
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US20120046182 |
NEOEPITOPE DETECTION OF DISEASE USING PROTEIN ARRAYS
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of...
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US20120028893 |
Adenovirus 36 E4 ORF 1 Gene and Protein and Their Uses
Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis....
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8093287 |
Inhibitors of matrix metalloproteinases
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and...
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US20120004428 |
Tri-Substituted 2-Benzhydryl-5-Benzylamino-Tetrahydro-Pyran-4-OL and 6-Benzhydryl-4-Benzylamino-Tetrahydro-Pyran-3-OL Analogues, and Novel 3,6-Disubstituted Pyran Derivatives
Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants.
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US20120003155 |
DENDRIMER BASED NANODEVICES FOR THERAPEUTIC AND IMAGING PURPOSES
A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of...
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8070836 |
Combined homogeneous and heterogeneous catalytic transesterification process for biodiesel production
In one aspect, a process for producing a biofuel comprises reacting a feed material that comprises a glyceride with an alcohol in the presence of a catalytic composition such that at least some of...
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8068994 |
Method for analyzing biological networks
Significance of biological pathway in disease state is predicted by (a) providing expression level data for a plurality of biomolecules differentially expressed in a disease state, compared with...
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US20110236484 |
Genus-Wide Chlamydial Peptide Vaccine Antigens
Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to...
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US20110224312 |
ENGINEERING POROUS PARTICLES OF WATER SOLUBLE THERAPEUTICS FOR PRESSURIZED METERED-DOSE INHALER FORMULATIONS
The subject matter disclosed herein relates to methods for engineering porous particles of water soluble therapeutics with enhanced physical stability and aerosol characteristics in...
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US20110224275 |
INHIBITORS OF MATRIX METALLOPROTEINASES
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and...
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US20110223216 |
Nanoparticles and Porous Particles and Methods of Making the Same
The subject matter disclosed herein relates to compositions and methods for engineering porous particles for aerosol formulations for pulmonary drug delivery. Certain embodiments disclosed herein...
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RE42700 |
Induction of apoptosis in cancer cells
The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
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8019398 |
Slide mechanism and slide-type portable terminal device using the same
An exemplary slide mechanism includes a main plate a slide plate, and two arched resilient members. The arched resilient members are disposed on the main plate. The slide plate is slidably laid...
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8017791 |
Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel, 3,6-disubstituted pyran derivatives
Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants.
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US20110212472 |
Asbestos Exposure, Pleural Mesothelioma and Osteopontin Levels
The present invention provides diagnostic and disease progression or recurrence prediction methods based on osteopontin levels in a biological sample.
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8008436 |
Adenovirus 36 E4 orf 1 gene and protein and their uses
Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis....
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7994602 |
Titanium dioxide thin film systems
A thin-film metal-oxide compound includes a titanium dioxide layer having a thickness of about 100 to 1000 nanometers. The titanium dioxide layer has a single-phase anatase structure. The titanium...
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7994123 |
Hybrid proteins with ErbB4 extracellular domain and neuregulin heparin-binding domain for targeting
Polypeptides of the neuregulin (NRG) heparin binding domain (N-HBD) and nucleic acids coding therefor are disclosed. In particular, fusion polypeptides are produced that comprise, as a targeting...
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US20110191874 |
COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING CELL DEATH BY A TRANSLATION REGULATED GENE EXPRESSION SYSTEM
The technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably...
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US20110152210 |
POLYPHENOL COMPOUNDS FOR INHIBITING PROTEASOME AND USES THEREOF
Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for...
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7964536 |
Neoepitope detection of disease using protein arrays
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of...
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US20110114233 |
DEVELOPMENT OF A HIGH STRENGTH HIGH TOUGHNESS BAINITIC STEEL
A bainitic steel with simultaneous high yield strength and high fracture toughness includes at least 5 volume percent austenite as well as iron, carbon, and silicon. The silicon is present in an...
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7928127 |
Inhibitors of matrix metallaproteinases
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and...
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7915433 |
Tri-substituted 2-benzhydryl 5-benzlamino-tetrahydro-pyran-4-OL and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-OL analogues, and novel 3,6 disubstituted pyran derivatives
Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants.
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7901896 |
Asbestos exposure, pleural mesothelioma, and osteopontin levels
The present invention provides diagnostic methods based on the levels of osteopontin.
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7901656 |
Metal oxide-containing nanoparticles
The present invention provides a copper oxide-containing composition that includes copper oxide nanoparticles and one or more heteroatom donor ligands bonded to the surface of the nanoparticles,...
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7888330 |
Phosphoramidate derivatives of FAU
The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly....
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US20110034422 |
DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS
Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular...
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US20110021748 |
Non-Natural Peptides as Models for the Development of Antibiotics
Described herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka...
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US20110020849 |
BIOMARKERS FOR DIAGNOSTIC AND THERAPEUTIC METHODS
Erythrocyte ATP-release modulators and composition and methods for their use as biomarkers of glucose processing or vascular disorders, as well as methods for screening to identify to modulators;...
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US20110020471 |
ERYTHROCYTE ATP-RELEASE MODULATORS
Erythrocyte ATP-release modulators and composition and methods for their use to potentiate serum glucose clearance and vasodilation; methods for prophylactic or palliative therapy of glucose...
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US20110020457 |
POLYMER-SURFACTANT NANOPARTICLES FOR SUSTAINED RELEASE OF COMPOUNDS
A polymer-surfactant nanoparticle formulation, using the anionic surfactant aerosol OT (AOT) and polysaccharide polymer alginate, is used for sustained release of water-soluble drugs. The...
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US20110003897 |
METHODS OF ENGINEERING POLAR DRUG PARTICLES WITH SURFACE-TRAPPED HYDROFLUOROALKANE-PHILES
Disclosed herein are polar drug particles with surface-trapped hydrofluoroalkane-philes and methods of making the same.
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US20110002930 |
Activated T Cells
Provided are compositions comprising activated T cells and activated T cells armed with bispecific antibodies directed at cancer antigens which are poor responders to alloantigen, and methods of...
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7863004 |
Neoepitope detection of disease using protein arrays
There is provided a diagnostic tool for use in diagnosing diseases, the tool having a detector for detecting the presence of an array of markers indicative of disease. Also provided is a...
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