Patents and Patent Applications from Washington University St Louis


Match Document Document Title
US20170348442 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS  
Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases,...
9834596 Antibodies to tau  
This invention relates to antibodies to tau and methods of use thereof.
US20170342436 TRANSGENIC PLANTS EXHIBITING ENHANCED PHYTOCHELATIN-BASED HEAVY METAL TOLERANCE AND METHODS OF USE THEREOF  
Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
US20170334944 NEUROACTIVE 19-ALKOXY-17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
US20170334865 DDR2 INHIBITORS AND METHODS OF USING  
Compounds that inhibit activation of Discoidin Domain Receptor 2 (DDR2) and methods of using the compounds to inhibit DDR2 activation, inhibit migration of cells expressing DDR2, and treat...
US20170332983 SYSTEMS AND METHODS FOR POINT-OF-CARE POSITRON EMISSION TOMOGRAPHY  
A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of...
9822362 Compositions and methods for treating lung disease and injury  
Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury,...
9814895 Method and device for three-stage atrial cardioversion therapy  
Methods and apparatus for a three-stage atrial cardioversion therapy that treats atrial arrhythmias within pain tolerance thresholds of a patient. An implantable therapy generator adapted to...
US20170324088 METHOD FOR THE USE OF SLURRIES IN SPRAY PYROLYSIS FOR THE PRODUCTION OF NON-HOLLOW, POROUS PARTICLES  
A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solid-phase particles in a liquid that...
US20170319323 BIOMEDICAL PATCHES WITH ALIGNED FIBERS  
A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an...
9809857 Methods and signatures for oropharyngeal cancer prognosis  
Methods for determining the prognosis of a subject with oropharyngeal squamous cell carcinoma are described, as well as miRNAs and panels of prognostic miRNAs that are used in the methods.
9809856 Method for predicting risk of metastasis  
The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the level of expression of one or more...
9808500 Antithrombotic nanoparticle  
The present invention encompasses an antithrombotic nanoparticle and use thereof.
US20170307639 TAU KINETIC MEASUREMENTS  
The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
US20170307590 INHIBITORS OF MALARIAL AND HUMAN GLUCOSE TRANSPORTERS AND METHODS FOR IDENTIFYING THE INHIBITORS  
Inhibitors of glucose transporter Plasmodium falciparum hexose transporter (PfHT) are provided herein. Further, a cell-based, high-throughput assay that directly measures the ability of a compound...
US20170304397 TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS  
Provided herein are methods of treating diseases associated with vascular calcification and/or cardiovascular disease in a subject by using the level of a biomarker, in particular, snail homolog 1...
US20170304084 METHODS AND SYSTEMS FOR CONTROLLING BODY PARTS AND DEVICES USING IPSILATERAL MOTOR CORTEX AND MOTOR RELATED CORTEX  
A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal...
US20170298142 ANTIBODIES TO TIP-1 AND GRP78  
The present invention is directed towards isolated antibodies that bind to GRP78.
9766402 Tunable add-drop filter with an active resonator  
An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one...
9765110 Neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
9764043 Antithrombotic nanoparticle  
The present invention encompasses an antithrombotic nanoparticle.
9750241 Blood substitute composition and method of use  
The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.
US20170249441 DEVELOPING PREDICTIVE DOSE-VOUME RELATIONSHIPS FOR A RADIOTHERAPY TREATMENT  
Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients,...
US20170247401 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS  
The present invention encompasses compounds and methods for treating urinary tract infections.
US20170246299 COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS  
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal...
D795550 Shoe insert  
9748567 Method for the use of slurries in spray pyrolysis for the production of non-hollow, porous particles  
A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solidphase particles in a liquid that...
9744379 Studying dosimetric impact of motion to generate adaptive patient-specific margins in EBRT planning  
A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a...
9738725 Antibodies to TIP-1  
The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
US20170237398 PHASE-SELECTIVE ENTRAINMENT OF NONLINEAR OSCILLATOR ENSEMBLES  
A system for entraining an oscillator ensemble is disclosed that includes a plurality of oscillators in an entrained phase pattern. The system includes an entrainment device operatively coupled to...
US20170233356 NEUROACTIVE SUBSTITUTED CYCLOPENT[a]ANTHRACENES AS MODULATORS FOR GABA TYPE-A RECEPTORS  
The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170232146 3D TISSUE-ENGINEERED BONE MARROW FOR PERSONALIZED THERAPY AND DRUG DEVELOPMENT  
A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived...
US20170232092 METHODS AND COMPOSITIONS FOR T CELL GENERATION AND USES THEREOF  
Among the various aspects of the present disclosure is the provision of a method of treating an inflammatory bowel disease. Another aspect provides the provision of a screening method for...
US20170232006 NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170231501 SUPER-PIXEL DETECTION FOR WEARABLE DIFFUSE OPTICAL TOMOGRAPHY  
A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a...
9733125 Resonator enhanced raman spectroscopy  
Embodiments of the invention provide Raman spectroscopy methods and devices that exploit high quality factor (Q) resonators to enhance Raman signal by several orders of magnitude over the signal...
9730816 Methods and systems for controlling body parts and devices using ipsilateral motor cortex and motor related cortex  
A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal...
US20170218465 COMPOSITIONS AND METHODS FOR DETECTING VIRUSES IN A SAMPLE  
The present disclosure provides a composition comprising a panel of probes for detecting one or more viruses in a sample. The panel of probes may be used to detect viruses in a biological sample...
US20170211155 METHOD FOR PREDICTING RISK OF METASTASIS  
The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the level of expression of one or more...
US20170209606 HYDROGELS FOR LOCALIZED RADIOTHERAPY  
Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be...
US20170209603 COMPOSITIONS TARGETING RADIATION-INDUCED MOLECULES AND METHODS OF USE THEREOF  
The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
US20170203113 Method for Low-Voltage Termination of Cardiac Arrhythmias by Effectively Unpinning Anatomical Reentries  
A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a...
US20170202475 DEPRESSION BRAIN COMPUTER INTERFACE FOR THE QUANTITATIVE ASSESSMENT OF MOOD STATE AND FOR BIOFEEDBACK FOR MOOD ALTERATION  
A brain computer interface (BCI) system includes an electroencephalogram (EEG) headset and a computing device communicatively coupled to the EEG headset. The computing device includes a memory, a...
US20170199971 ACCEPTANCE, COMMISSIONING, AND ONGOING BENCHMARKING OF A LINEAR ACCELERATOR (LINAC) USING AN ELECTRONIC PORTAL IMAGING DEVICE (EPID)  
The present invention is a method or system for acceptance testing and commissioning of a LINAC and treatment planning system (TPS). For a LINAC commissioning, the present invention collects...
US20170197912 SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE  
The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic...
US20170190732 NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170189566 ALPHA-SYNUCLEIN LIGANDS  
The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled...
US20170188571 SYSTEMS AND METHODS FOR NORMOTHERMIC EXTRACORPOREAL ORGAN PERFUSION  
A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in...
US20170183385 METHODS AND COMPOSITIONS FOR RED-SHIFTED CHROMOPHORE SUBSTITUTION FOR OPTOGENETIC APPLICATIONS  
The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme.
US20170181424 BLOOD SUBSTITUTE COMPOSITION AND METHOD OF USE  
The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.