Patents and Patent Applications from Washington University St Louis


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US20180164307 MICRO-RESONATOR AND FIBER TAPER SENSOR SYSTEM  
A micro-resonator and fiber taper based sensing system, which uses mode splitting or frequency shift methods and polarization measurements for particle sensing.
9987371 Compositions and methods for polynucleotide transfection  
A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
US20180148757 METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION  
The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
US20180147042 BIOMEDICAL PATCHES WITH ALIGNED FIBERS  
A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an...
9982299 Markers for brain damage  
Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.
9980660 Systems and methods for on-site and real-time electrocardiographic imaging (ECGI)  
A non-transitory computer readable medium stores instructions that, when executed by at least one processor, cause the at least one processor to perform a method that includes computing a transfer...
9974870 Compositions and methods for treatment and imaging using nanoparticles  
The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect...
US20180132728 DRY COUPLING APPARATUS FOR PHOTOACOUSTIC COMPUTED TOMOGRAPHY SYSTEMS  
An apparatus for holding an imaging subject, such as a whole animal, within a photoacoustic computed tomography system with dry acoustic coupling is disclosed. The apparatus includes a dry...
US20180131861 CAMERA CALIBRATION WITH LENTICULAR ARRAYS  
The present disclosure is directed to an approach to solve camera calibration from a single picture of a simply structured light field created by viewing a carefully designed lenticular sheet. The...
US20180120336 METHODS OF DIAGNOSING AND TREATING CANCER COMPRISING ME1  
The present disclosure provides a method of determining treatment for cancer comprising identifying the absence of malic enzyme 1 (ME1) and treating with an inducer of ferroptosis.
US20180119106 3D-PRINTED SCAFFOLD DEVICE FOR CELL TRANSPLANTATION  
Disclosed herein is a 3D-printed, biocompatible macroporous device that houses stem cell derived β-cell (SC-β cell) clusters within a degradable fibrin gel. Cluster sizes are used that avoid...
US20180116521 SYSTEMS AND METHODS FOR MEASURING CARDIAC STRAIN  
A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in...
9957289 Compounds and methods for treating bacterial infections  
The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili...
US20180114577 SELF-POWERED TIMERS AND METHODS OF USE  
A timer module including a timer and a compensation circuit coupled to the timer is provided. The timer measures time over a first monitoring period. The timer includes a floating-gate and an...
US20180109325 OPTO-MECHANICAL SYSTEM AND METHOD HAVING CHAOS INDUCED STOCHASTIC RESONANCE AND OPTO-MECHANICALLY MEDIATED CHAOS TRANSFER  
An a system and method for chaos transfer between multiple detuned signals in a resonator mediated by chaotic mechanical oscillation induced stochastic resonance where at least one signal is...
US20180105793 DEVICE WITH MULTIPLE MICROENVIRONMENTS AND METHODS THEREOF  
Among the various aspects of the present disclosure is the provision of a device with multiple microenvironments and methods of use and manufacture thereof. An aspect of the present disclosure...
9939153 Method and apparatus for capturing carbon dioxide during combustion of carbon containing fuel  
A boiler system having a series of boilers. Each boiler includes a shell having an upstream end, a downstream end, and a hollow interior. The boilers also have an oxidizer inlet entering the...
US20180097478 PHASE-SELECTIVE ENTRAINMENT OF NONLINEAR OSCILLATOR ENSEMBLES  
A system for entraining an oscillator ensemble is disclosed that includes a plurality of oscillators in an entrained phase pattern. The system includes an entrainment device operatively coupled to...
US20180094259 METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs  
The present invention relates to compositions and methods for detecting motor neuron-specific miRNAs in a population of cells or subject. More particularly, the invention relates to detecting...
US20180087957 SYSTEMS AND METHODS FOR EMBEDDED SENSORS WITH VARIANCE-BASED LOGIC  
A variance-based substrate computing system is disclosed. The variance-based computing system includes a sensor configured to be embedded in a structure, the sensor further configured to generate...
US20180086727 NEUROACTIVE SUBSTITUTED CYCLOPENT[a]ANTHRACENES AS MODULATORS FOR GABA TYPE-A RECEPTORS  
The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20180080926 PEPTIDE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE  
Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating...
9914761 Oligomers for TNF superfamily inhibition  
Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to...
US20180066936 SYSTEM AND METHOD FOR QUANTIFYING DEFORMATION, DISRUPTION, AND DEVELOPMENT IN A SAMPLE  
A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes...
US20180066015 INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES  
The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present...
US20180064932 SYSTEM FOR STIMULATING BONE GROWTH, TISSUE HEALING AND/OR PAIN CONTROL, AND METHOD OF USE  
A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode...
US20180064712 METHODS OF REDUCING IMMUNE CELL ACTIVATION AND USES THEREOF  
The present invention encompasses methods of reducing inflammatory immune cell activation and inflammation via inhibiting mitochondrial fission.
9910048 Method for detection of aggregates in biological samples  
The present invention provides a method for detecting protein aggregates in a biological sample, and uses thereof.
9909170 Method for multiplexed nucleic acid patch polymerase chain reaction  
The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
9908929 Collagen matrix with locally controlled intrafibrillar and extrafibrillar mineral content and methods of producing  
A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen...
US20180055923 COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF Ebp PILUS-RELATED DISEASES  
The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
US20180055408 QUANTITATIVE DIFFERENTIATION OF INFLAMMATION FROM SOLID TUMORS, HEART AND NERVE INJURY  
D-Histo, a non-invasive diagnostic method, renovated from diffusion basis spectrum imaging (DBSI) is provided for quantitatively detecting and distinguishing inflammation from solid tumors, heart...
US20180051301 INDUCTION OF PACEMAKER-LIKE CELLS FROM CARDIOMYOCYTES  
Disclosed are compositions and methods relating to the cardiac conduction system. Compositions, methods for converting cardiac tissue to an induced-sinoatrial node, and methods for treating sinus...
US20180049977 HYDROGEL MICROPARTICLE SCAFFOLD WITH GRADIENTS OF DEGRADABILITY AND METHODS THEREOF  
Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of...
US20180043278 BILAYERED STRUCTURES FOR SOLAR STEAM GENERATION  
The present disclosure is directed to steam generation through the efficient harvesting of solar energy. In particular, the present disclosure is directed to bilayered structures that are...
US20180042541 Fast, Continuous Psychometric Estimation System Utilizing Machine Learning and Associated Method of Use  
A method and system for of computerized psychometric testing of sensory information that includes selecting stimulus parameters for a first stimulus to be applied with a stimulus inducer, applying...
US20180037641 ANTIBODIES TO TAU  
This invention relates to antibodies to tau and methods of use thereof.
9885051 Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety  
The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
US20180031483 BIOPLASMONIC DETECTION OF BIOMARKERS IN BODY FLUIDS USING PEPTIDE RECOGNITION ELEMENTS  
Plasmonic nanotransducers and methods for label-free detection of biomarkers are disclosed. The plasmonic nanotransducers include nanostructure cores and peptide aptamers. The plasmonic...
US20180021462 HOMING AGENTS  
The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest,...
US20180017647 METHODS FOR SIMULTANEOUS MULTI-ANGULAR RELAXOMETRY AND RF MAPPING OF TISSUE USING MAGNETIC RESONANCE IMAGING  
Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to...
US20180016328 ANTI-TAU CONSTRUCTS  
The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and...
US20180014971 THERMALLY CONDUCTIVE GRAFT  
The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological...
US20180014837 DISCECTOMY INSTRUMENT  
A discectomy instrument for use with a cutting tool including a flexible shaft and an implement extending from the shaft generally includes a guard including a shaft and a foot extending...
US20180014720 SELF-CLEANING ENDOSCOPE  
A self-cleaning endoscope and methods of using the same are described. The self-cleaning endoscope includes a housing having a distal end and a proximal end opposite the distal end, a lens...
9868947 Compositions and methods for the construction of a random allelic series  
The present disclosure provides a method of making a systematic single point mutation in a target nucleic acid and a method of generating a mutational library comprising target nucleic acids with...
US20180010102 TOOLKIT FOR THE PRODUCTION OF POST-TRANSLATIONALLY MODIFIED PROTEINS  
The present disclosure provides a system to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein comprising a catalytic domain of an enzyme...
US20180002747 DETECTION OF RARE SEQUENCE VARIANTS, METHODS AND COMPOSITIONS THEREFOR  
The present disclosure encompasses methods of error corrected sequencing (ECS) that enable detection of very rare mutations well below the error rate of convention next generation sequencing...
US20180000918 VACCINE COMPOSITIONS FOR USE AGAINST ENTEROTOXIGENIC ESCHERICHIA COLI  
The present disclosure provides vaccine compositions for use against enterotoxigenic Escherichia coli (ETEC) comprising EtpA and EatA. EtpA and EatA are prevalent amount diverse ETEC isolates and...
US20170371104 TUNABLE ADD-DROP FILTER WITH AN ACTIVE RESONATOR  
An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one...