Patents and Patent Applications from Washington University St Louis


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US20180051301 INDUCTION OF PACEMAKER-LIKE CELLS FROM CARDIOMYOCYTES  
Disclosed are compositions and methods relating to the cardiac conduction system. Compositions, methods for converting cardiac tissue to an induced-sinoatrial node, and methods for treating sinus...
US20180049977 HYDROGEL MICROPARTICLE SCAFFOLD WITH GRADIENTS OF DEGRADABILITY AND METHODS THEREOF  
Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of...
US20180043278 BILAYERED STRUCTURES FOR SOLAR STEAM GENERATION  
The present disclosure is directed to steam generation through the efficient harvesting of solar energy. In particular, the present disclosure is directed to bilayered structures that are...
US20180042541 Fast, Continuous Psychometric Estimation System Utilizing Machine Learning and Associated Method of Use  
A method and system for of computerized psychometric testing of sensory information that includes selecting stimulus parameters for a first stimulus to be applied with a stimulus inducer, applying...
US20180037641 ANTIBODIES TO TAU  
This invention relates to antibodies to tau and methods of use thereof.
9885051 Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety  
The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
US20180031483 BIOPLASMONIC DETECTION OF BIOMARKERS IN BODY FLUIDS USING PEPTIDE RECOGNITION ELEMENTS  
Plasmonic nanotransducers and methods for label-free detection of biomarkers are disclosed. The plasmonic nanotransducers include nanostructure cores and peptide aptamers. The plasmonic...
US20180021462 HOMING AGENTS  
The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest,...
US20180017647 METHODS FOR SIMULTANEOUS MULTI-ANGULAR RELAXOMETRY AND RF MAPPING OF TISSUE USING MAGNETIC RESONANCE IMAGING  
Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to...
US20180016328 ANTI-TAU CONSTRUCTS  
The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and...
US20180014971 THERMALLY CONDUCTIVE GRAFT  
The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological...
US20180014837 DISCECTOMY INSTRUMENT  
A discectomy instrument for use with a cutting tool including a flexible shaft and an implement extending from the shaft generally includes a guard including a shaft and a foot extending...
US20180014720 SELF-CLEANING ENDOSCOPE  
A self-cleaning endoscope and methods of using the same are described. The self-cleaning endoscope includes a housing having a distal end and a proximal end opposite the distal end, a lens...
9868947 Compositions and methods for the construction of a random allelic series  
The present disclosure provides a method of making a systematic single point mutation in a target nucleic acid and a method of generating a mutational library comprising target nucleic acids with...
US20180010102 TOOLKIT FOR THE PRODUCTION OF POST-TRANSLATIONALLY MODIFIED PROTEINS  
The present disclosure provides a system to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein comprising a catalytic domain of an enzyme...
US20180002747 DETECTION OF RARE SEQUENCE VARIANTS, METHODS AND COMPOSITIONS THEREFOR  
The present disclosure encompasses methods of error corrected sequencing (ECS) that enable detection of very rare mutations well below the error rate of convention next generation sequencing...
US20180000918 VACCINE COMPOSITIONS FOR USE AGAINST ENTEROTOXIGENIC ESCHERICHIA COLI  
The present disclosure provides vaccine compositions for use against enterotoxigenic Escherichia coli (ETEC) comprising EtpA and EatA. EtpA and EatA are prevalent amount diverse ETEC isolates and...
US20170371104 TUNABLE ADD-DROP FILTER WITH AN ACTIVE RESONATOR  
An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one...
US20170369864 INHIBITION AND DIAGNOSTICS OF EMERGING TETRACYCLINE RESISTANCE ENZYMES  
The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a...
US20170368104 INDUCTION OF TOLERANCE IN LUNG ALLOGRAFT TRANSPLANTATION  
The present disclosure relates to methods of inducing tolerance to lung allograft transplantation. These methods comprise increasing suppressor CD8+ T cells and/or suppressing deleterious CD8+ and...
US20170367586 PHOTOACOUSTIC COMPUTED TOMOGRAPHY WITH AN ACOUSTIC REFLECTOR  
Systems and methods for improving limited-view photoacoustic tomography using an acoustic reflector are described. In particular, an acoustic reflector and ultrasonic transducer array are...
US20170367323 BLOOD SUBSTITUTE COMPOSITION AND METHOD OF USE  
The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.
9849201 Homing agents  
The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest,...
US20170363284 RADIANT BOILER FOR PRESSURIZED OXY-COMBUSTION AND METHOD OF RADIANT TRAPPING TO CONTROL HEAT FLUX IN HIGH TEMPERATURE PARTICLE-LADEN FLOWS AT ELEVATED PRESSURE  
A boiler has a shell surrounding a vertical centerline. The shell defines an inner surface having an inner diameter and an inner length extending between an upper upstream end and a lower...
US20170360554 COMPOSTIONS AND METHODS FOR TISSUE REPAIR  
Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or...
9844662 System for stimulating bone growth, tissue healing and/or pain control, and method of use  
A system for use in stimulating bone growth, tissue healing, and/or pain control is described. The system includes a screw, a battery, a controller, and means for connecting the battery such that...
US20170355728 NEUROACTIVE 13, 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS  
The present disclosure is generally directed to neuroactive 13, 17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic,...
US20170355675 SULFUR-CONTAINING COMPOUNDS TARGETING VESICULAR ACETYLCHOLINE TRANSPORTER  
The present invention generally relates to various compounds that are useful as vesicular acetylcholine transporter (VAChT) ligands. The invention further relates to methods of using these...
9839682 Compositions and methods for the treatment and prevention of Ebp pilus-related diseases  
The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
US20170348442 COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS  
Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases,...
9834596 Antibodies to tau  
This invention relates to antibodies to tau and methods of use thereof.
US20170342436 TRANSGENIC PLANTS EXHIBITING ENHANCED PHYTOCHELATIN-BASED HEAVY METAL TOLERANCE AND METHODS OF USE THEREOF  
Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
US20170334944 NEUROACTIVE 19-ALKOXY-17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
US20170334865 DDR2 INHIBITORS AND METHODS OF USING  
Compounds that inhibit activation of Discoidin Domain Receptor 2 (DDR2) and methods of using the compounds to inhibit DDR2 activation, inhibit migration of cells expressing DDR2, and treat...
US20170332983 SYSTEMS AND METHODS FOR POINT-OF-CARE POSITRON EMISSION TOMOGRAPHY  
A positron emission tomography (PET) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of...
9822362 Compositions and methods for treating lung disease and injury  
Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury,...
9814895 Method and device for three-stage atrial cardioversion therapy  
Methods and apparatus for a three-stage atrial cardioversion therapy that treats atrial arrhythmias within pain tolerance thresholds of a patient. An implantable therapy generator adapted to...
US20170324088 METHOD FOR THE USE OF SLURRIES IN SPRAY PYROLYSIS FOR THE PRODUCTION OF NON-HOLLOW, POROUS PARTICLES  
A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solid-phase particles in a liquid that...
US20170319323 BIOMEDICAL PATCHES WITH ALIGNED FIBERS  
A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an...
9809857 Methods and signatures for oropharyngeal cancer prognosis  
Methods for determining the prognosis of a subject with oropharyngeal squamous cell carcinoma are described, as well as miRNAs and panels of prognostic miRNAs that are used in the methods.
9809856 Method for predicting risk of metastasis  
The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the level of expression of one or more...
9808500 Antithrombotic nanoparticle  
The present invention encompasses an antithrombotic nanoparticle and use thereof.
US20170307639 TAU KINETIC MEASUREMENTS  
The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
US20170307590 INHIBITORS OF MALARIAL AND HUMAN GLUCOSE TRANSPORTERS AND METHODS FOR IDENTIFYING THE INHIBITORS  
Inhibitors of glucose transporter Plasmodium falciparum hexose transporter (PfHT) are provided herein. Further, a cell-based, high-throughput assay that directly measures the ability of a compound...
US20170304397 TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS  
Provided herein are methods of treating diseases associated with vascular calcification and/or cardiovascular disease in a subject by using the level of a biomarker, in particular, snail homolog 1...
US20170304084 METHODS AND SYSTEMS FOR CONTROLLING BODY PARTS AND DEVICES USING IPSILATERAL MOTOR CORTEX AND MOTOR RELATED CORTEX  
A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal...
US20170298142 ANTIBODIES TO TIP-1 AND GRP78  
The present invention is directed towards isolated antibodies that bind to GRP78.
9766402 Tunable add-drop filter with an active resonator  
An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one...
9765110 Neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
9764043 Antithrombotic nanoparticle  
The present invention encompasses an antithrombotic nanoparticle.