Patents and Patent Applications from Washington University St Louis


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9766402 Tunable add-drop filter with an active resonator  
An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one...
9765110 Neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
9764043 Antithrombotic nanoparticle  
The present invention encompasses an antithrombotic nanoparticle.
9750241 Blood substitute composition and method of use  
The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.
US20170249441 DEVELOPING PREDICTIVE DOSE-VOUME RELATIONSHIPS FOR A RADIOTHERAPY TREATMENT  
Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients,...
US20170247401 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS  
The present invention encompasses compounds and methods for treating urinary tract infections.
US20170246299 COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS  
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal...
D795550 Shoe insert  
9748567 Method for the use of slurries in spray pyrolysis for the production of non-hollow, porous particles  
A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solidphase particles in a liquid that...
9744379 Studying dosimetric impact of motion to generate adaptive patient-specific margins in EBRT planning  
A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a...
9738725 Antibodies to TIP-1  
The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
US20170237398 PHASE-SELECTIVE ENTRAINMENT OF NONLINEAR OSCILLATOR ENSEMBLES  
A system for entraining an oscillator ensemble is disclosed that includes a plurality of oscillators in an entrained phase pattern. The system includes an entrainment device operatively coupled to...
US20170233356 NEUROACTIVE SUBSTITUTED CYCLOPENT[a]ANTHRACENES AS MODULATORS FOR GABA TYPE-A RECEPTORS  
The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170232146 3D TISSUE-ENGINEERED BONE MARROW FOR PERSONALIZED THERAPY AND DRUG DEVELOPMENT  
A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived...
US20170232092 METHODS AND COMPOSITIONS FOR T CELL GENERATION AND USES THEREOF  
Among the various aspects of the present disclosure is the provision of a method of treating an inflammatory bowel disease. Another aspect provides the provision of a screening method for...
US20170232006 NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170231501 SUPER-PIXEL DETECTION FOR WEARABLE DIFFUSE OPTICAL TOMOGRAPHY  
A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a...
9733125 Resonator enhanced raman spectroscopy  
Embodiments of the invention provide Raman spectroscopy methods and devices that exploit high quality factor (Q) resonators to enhance Raman signal by several orders of magnitude over the signal...
9730816 Methods and systems for controlling body parts and devices using ipsilateral motor cortex and motor related cortex  
A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal...
US20170218465 COMPOSITIONS AND METHODS FOR DETECTING VIRUSES IN A SAMPLE  
The present disclosure provides a composition comprising a panel of probes for detecting one or more viruses in a sample. The panel of probes may be used to detect viruses in a biological sample...
US20170211155 METHOD FOR PREDICTING RISK OF METASTASIS  
The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the level of expression of one or more...
US20170209606 HYDROGELS FOR LOCALIZED RADIOTHERAPY  
Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be...
US20170209603 COMPOSITIONS TARGETING RADIATION-INDUCED MOLECULES AND METHODS OF USE THEREOF  
The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
US20170203113 Method for Low-Voltage Termination of Cardiac Arrhythmias by Effectively Unpinning Anatomical Reentries  
A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a...
US20170202475 DEPRESSION BRAIN COMPUTER INTERFACE FOR THE QUANTITATIVE ASSESSMENT OF MOOD STATE AND FOR BIOFEEDBACK FOR MOOD ALTERATION  
A brain computer interface (BCI) system includes an electroencephalogram (EEG) headset and a computing device communicatively coupled to the EEG headset. The computing device includes a memory, a...
US20170199971 ACCEPTANCE, COMMISSIONING, AND ONGOING BENCHMARKING OF A LINEAR ACCELERATOR (LINAC) USING AN ELECTRONIC PORTAL IMAGING DEVICE (EPID)  
The present invention is a method or system for acceptance testing and commissioning of a LINAC and treatment planning system (TPS). For a LINAC commissioning, the present invention collects...
US20170197912 SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE  
The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic...
US20170190732 NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170189566 ALPHA-SYNUCLEIN LIGANDS  
The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled...
US20170188571 SYSTEMS AND METHODS FOR NORMOTHERMIC EXTRACORPOREAL ORGAN PERFUSION  
A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in...
US20170183385 METHODS AND COMPOSITIONS FOR RED-SHIFTED CHROMOPHORE SUBSTITUTION FOR OPTOGENETIC APPLICATIONS  
The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme.
US20170181424 BLOOD SUBSTITUTE COMPOSITION AND METHOD OF USE  
The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.
US20170176563 METHODS FOR SIMULTANEOUS MULTI-ANGULAR RELAXOMETRY AND RF MAPPING OF TISSUE USING MAGNETIC RESONANCE IMAGING  
Methods of obtaining quantitative MRI images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to...
9683268 Viruses associated with immunodeficiency and enteropathy and methods using same  
The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The...
9679110 Developing predictive dose-volume relationships for a radiotherapy treatment  
Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients,...
9676812 Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same  
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
9675732 3D tissue-engineered bone marrow for personalized therapy and drug development  
A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived...
US20170163971 MULTIPLE-VIEW COMPRESSED-SENSING ULTRAFAST PHOTOGRAPHY (MV-CUP)  
A system and method for compressed-sensing ultrafast photography for two-dimensional dynamic imaging is disclosed. The system and method may capture non-repetitive time-evolving events at up to...
US20170152284 NEUROACTIVE 19-ALKOXY-17(20)-Z-VINYLCYANO-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
US20170152282 NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME  
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an...
US20170146628 DIAGNOSIS OF CENTRAL NERVOUS SYSTEM WHITE MATTER PATHOLOGY USING DIFFUSION MRI  
A method of performing diffusion basis spectrum imaging (DBSI) within a tissue of a patient using diffusion magnetic resonance data acquired from a portion of the tissue is disclosed. The...
US20170146557 METHODS OF DETERMINING AMYLOID BETA TURNOVER IN BLOOD  
The present invention encompasses a method for determining Aβ turnover in blood.
9655952 Blood substitute composition and method of use  
The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.
9655527 Quantification of optical absorption coefficients using acoustic spectra in photoacoustic tomography  
Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the...
US20170136030 TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY  
Compounds are disclosed that inhibit the methylerythritol cytidyltransferase (IspD) enzyme in the non-mevalonate pathway (MEP pathway), which is present in many organisms including the P....
US20170135656 INSERT DEVICE FOR ENHANCING PET AND MRI IMAGES  
Insert devices that include a RF surface coil and gamma-ray photon detector array for enhancing PET and MRI images produced from integrated PET-MRI scanners are disclosed. Integrated PET-MRI...
US20170124255 Method and Apparatus for Performing Similarity Searching  
A system and method for performing similarity searching is disclosed wherein programmable logic devices such as field programmable gate arrays (FPGAs) can be used to implement Bloom filters for...
US20170119467 THERMOABLATION PROBE  
A thermoablation probe for performing an interstitial thermal therapy (ITT) procedure on a brain lesion generally includes a rigid sheath and a flexible treatment device telescopically slidable...
9636379 Compositions and methods for treating pruritus  
The present invention encompasses methods and compositions for alleviating pruritus. The compositions may comprise an analgesic agent.
9631239 Method of classifying a breast cancer instrinsic subtype  
Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm...