Patents and Patent Applications from Washington University St Louis


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10080687 Biomedical patches with spatially arranged fibers  
A structure for use in repairing a defect in a substrate is provided. The structure includes a first layer and a second layer coupled to the first layer using a first coupling process. The first...
US20180265905 CHEMOENZYMATIC SYNTHESIS OF PEPTIDE BETA-LACTONES AND BETA-HYDROXY ACIDS  
Methods of producing peptide beta-lactones and beta-hydroxy acids are disclosed that include contacting a beta-hydroxy-alpha-amino acid, an aryl carrier protein (ObiD), and ATP with a...
US20180258399 Method of Making Trabecular Bone  
Provided herein are methods of producing trabecular bone material, such as trabecular bone or trabecular bone matrix and cells useful in preparing the trabecular bone material.
10072924 System and method for quantifying deformation, disruption, and development in a sample  
A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes...
10071257 Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries  
A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a...
10070813 Photoacoustic and thermoacoustic tomography for breast imaging  
A system for imaging a biological sample including a tubular body having a side wall defining an interior shaped and sized for receiving the biological sample, an electromagnetic source positioned...
US20180252712 RECEPTOR FOR NOROVIRUS AND USES THEREOF  
The present disclosure provides compositions and cell comprising a norovirus receptor as well as methods of use thereof. Such uses include identification of anti-viral compounds, treatment of...
10066008 Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv  
The present invention provides isolated antibodies that bind to 14-3-3 epsilon that are useful in the recognition of tumor cells and tumor specific delivery of drugs and therapies.
10064842 KCNQ channels as therapeutic targets  
The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with...
US20180243576 METHOD AND DEVICE FOR THREE-STAGE ATRIAL CARDOIVERSION THERAPY  
Methods and apparatus for a three-stage atrial cardioversion therapy that treats atrial arrhythmias within pain tolerance thresholds of a patient. An implantable therapy generator adapted to...
US20180243546 BREAKAWAY CONNECTOR  
A breakaway connector generally includes a first valve having a first rotating-type fluid control member, and a second valve that is attachable to the first valve and has a second rotating-type...
10060925 Miox antibody and assay  
The invention relates to compositions and methods for detecting renal injury in a subject, such as proximal tubular injury associated with acute kidney injury.
10060924 Distinguishing flavivirus infection using a recombinant mutant envelope protein  
The present invention relates to mutant peptides of the E protein of the West Nile virus and other flaviviruses useful for discriminating flaviviral infections, as well as kits, methods and uses...
10053487 Neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same  
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for...
US20180230181 ISOFORM-SELECTIVE LYSINE DEACETYLASE INHIBITORS  
Isoform-selective lysine deacetylase inhibitors are described. Inhibitors of the lysine deacetylase enzyme are useful as antitumor drugs and for treating addiction, asthma, cardio-vascular...
US20180228868 COMPOSITIONS AND METHODS FOR MODULATION OF DIETARY AND MICROBIAL EXPOSURE  
Among the various aspects of the present disclosure is the provision of compositions and methods for modulation of dietary and microbial exposure. The present disclosure provides for compositions...
10047130 Methods and compositions for red-shifted chromophore substitution for optogenetic applications  
The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme.
US20180224552 COMPRESSED-SENSING ULTRAFAST PHOTOGRAPHY (CUP)  
A system and method for compressed-sensing ultrafast photography for two-dimensional dynamic imaging is disclosed. The system and method may capture non-repetitive time-evolving events at up to...
US20180214416 TREATMENT FOR WOLFRAM SYNDROME AND OTHER ENDOPLASMIC RETICULUM STRESS DISORDERS  
The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
10037395 Systems and methods for improving battery performance  
A computer-implemented method for modeling the amount of current discharged by a battery is provided. The method is implemented by a computing device communicatively coupled with a memory, and...
US20180210861 BATTERY MODELS, SYSTEMS, AND METHODS USING ROBUST FAIL-SAFE ITERATION FREE APPROACH FOR SOLVING DIFFERENTIAL ALGEBRAIC EQUATIONS  
Battery models using robust fail-safe iteration free approach for solving Differential Algebraic Equations, and associated systems and methods are disclosed. In one embodiment, a method includes...
US20180204358 FREE-BREATHING AND SELF-NAVIGATED MRI METHOD FOR DEFORMABLE MOTION DERIVATION  
Systems and methods for producing motion-corrected MR images that include an MRI scanner with a plurality of coils in which the plurality of coils is configured to detect a plurality of MR imaging...
US20180203084 DUAL FLIP ANGLE MULTI-ECHO ULTRA-SHORT ECHO TIME (DUFA-MUTE) MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS AND METHODS  
Systems and methods for producing pseudo-CT images using a dual flip angle multi-echo ultra-short echo time (DUFA-MUTE) MRI method are disclosed. The DUFA-MUTE MRI imaging method includes...
US20180200226 COMPOSITIONS AND METHODS OF USE OF ANTIBACTERIAL DRUG COMBINATIONS  
The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria.
US20180200018 SYSTEM AND METHOD FOR VIRTUAL REALITY DATA INTEGRATION AND VISUALIZATION FOR 3D IMAGING AND INSTRUMENT POSITION DATA  
Systems and methods for virtual reality or augmented reality (VR/AR) visualization of 3D medical images using a VR/AR visualization system are disclosed. The VR/AR visualization system includes a...
US20180194792 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS  
The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili...
US20180193455 ANTIBODIES TO TUMOR ASSOCIATED COMPLEX N-GLYCANS WITH TERMINAL GLCNACBETA RESIDUES AND METHODS OF USE THEREOF  
The present disclosure relates to antibodies specific tumor associated complex N-glycans with terminal GlcNAcβ residues and methods for detecting a tumor in a subject. The present disclosure also...
US20180192952 FULLY IMPLANTABLE SOFT MEDICAL DEVICES FOR INTERFACING WITH BIOLOGICAL TISSUE  
Provided are fully implantable soft medical devices and related methods. The devices comprise stretchable electronic devices between on an elastomeric substrate and an elastomeric super-state....
10017832 Compositions and methods for site specific recombination at asymmetric sites  
The present invention relates to enzymes, compositions and methods for catalyzing site specific recombination at asymmetric sites.
US20180187887 METHOD AND APPARATUS FOR CAPTURING CARBON DIOXIDE DURING COMBUSTION OF CARBON CONTAINING FUEL  
A boiler system having a series of boilers. Each boiler includes a shell having an upstream end, a downstream end, and a hollow interior. The boilers also have an oxidizer inlet entering the...
US20180177920 GLASS DERIVED NANOPARTICLES FOR NERVE TISSUE REPAIR  
A biocompatible, biodegradable composite material, and method of using nanoparticles formed within the composite material for nerve repair are disclosed. The nanoparticles may not be formed until...
US20180164307 MICRO-RESONATOR AND FIBER TAPER SENSOR SYSTEM  
A micro-resonator and fiber taper based sensing system, which uses mode splitting or frequency shift methods and polarization measurements for particle sensing.
9987371 Compositions and methods for polynucleotide transfection  
A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
US20180148757 METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION  
The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
US20180147042 BIOMEDICAL PATCHES WITH ALIGNED FIBERS  
A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an...
9982299 Markers for brain damage  
Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.
9980660 Systems and methods for on-site and real-time electrocardiographic imaging (ECGI)  
A non-transitory computer readable medium stores instructions that, when executed by at least one processor, cause the at least one processor to perform a method that includes computing a transfer...
9974870 Compositions and methods for treatment and imaging using nanoparticles  
The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect...
US20180132728 DRY COUPLING APPARATUS FOR PHOTOACOUSTIC COMPUTED TOMOGRAPHY SYSTEMS  
An apparatus for holding an imaging subject, such as a whole animal, within a photoacoustic computed tomography system with dry acoustic coupling is disclosed. The apparatus includes a dry...
US20180131861 CAMERA CALIBRATION WITH LENTICULAR ARRAYS  
The present disclosure is directed to an approach to solve camera calibration from a single picture of a simply structured light field created by viewing a carefully designed lenticular sheet. The...
US20180120336 METHODS OF DIAGNOSING AND TREATING CANCER COMPRISING ME1  
The present disclosure provides a method of determining treatment for cancer comprising identifying the absence of malic enzyme 1 (ME1) and treating with an inducer of ferroptosis.
US20180119106 3D-PRINTED SCAFFOLD DEVICE FOR CELL TRANSPLANTATION  
Disclosed herein is a 3D-printed, biocompatible macroporous device that houses stem cell derived β-cell (SC-β cell) clusters within a degradable fibrin gel. Cluster sizes are used that avoid...
US20180116521 SYSTEMS AND METHODS FOR MEASURING CARDIAC STRAIN  
A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in...
9957289 Compounds and methods for treating bacterial infections  
The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili...
US20180114577 SELF-POWERED TIMERS AND METHODS OF USE  
A timer module including a timer and a compensation circuit coupled to the timer is provided. The timer measures time over a first monitoring period. The timer includes a floating-gate and an...
US20180109325 OPTO-MECHANICAL SYSTEM AND METHOD HAVING CHAOS INDUCED STOCHASTIC RESONANCE AND OPTO-MECHANICALLY MEDIATED CHAOS TRANSFER  
An a system and method for chaos transfer between multiple detuned signals in a resonator mediated by chaotic mechanical oscillation induced stochastic resonance where at least one signal is...
US20180105793 DEVICE WITH MULTIPLE MICROENVIRONMENTS AND METHODS THEREOF  
Among the various aspects of the present disclosure is the provision of a device with multiple microenvironments and methods of use and manufacture thereof. An aspect of the present disclosure...
9939153 Method and apparatus for capturing carbon dioxide during combustion of carbon containing fuel  
A boiler system having a series of boilers. Each boiler includes a shell having an upstream end, a downstream end, and a hollow interior. The boilers also have an oxidizer inlet entering the...
US20180097478 PHASE-SELECTIVE ENTRAINMENT OF NONLINEAR OSCILLATOR ENSEMBLES  
A system for entraining an oscillator ensemble is disclosed that includes a plurality of oscillators in an entrained phase pattern. The system includes an entrainment device operatively coupled to...
US20180094259 METHODS TO DETECT MOTOR NEURON DISEASE COMPRISING MICRO-RNAs  
The present invention relates to compositions and methods for detecting motor neuron-specific miRNAs in a population of cells or subject. More particularly, the invention relates to detecting...