Patents and Patent Applications from Wake Forest University


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10481153 Integrated compound discovery systems and methods  
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with...
US20190345439 COMPOSITIONS, CELL CONSTRUCTS, AND METHODS OF MAKING AND USING THE SAME  
An extrudable hydrogel composition useful for making a three-dimensional organ construct is described herein. Methods of using the same and products so made are also described. Also described...
US20190345096 HYDROGEN-BONDING COMPOUNDS, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME  
Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid...
10473662 Diagnostic and prognostic markers for cancer  
Compositions and methods useful for diagnosis and prognosis of cancer are provided. More particularly, methods for detecting breast or prostate cancer protein or nucleic acid biomarkers consisting...
10449388 Systems and methods for specifying treatment criteria and treatment parameters for patient specific radiation therapy planning  
Disclosed herein are systems and methods for specifying treatment criteria and treatment planning parameters for patient specific radiation therapy planning. According to an aspect, a method...
10443105 Methods and compositions for correlating genetic markers with prostate cancer risk  
The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and...
10434213 Controlled delivery system  
Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of...
US20190290685 COMPOSITIONS AND ASSOCIATED METHODS OF MESOPOROUS NANOPARTICLES COMPRISING PLATINUM-ACRIDINE MOLECULES  
Large-pore mesoporous silica nanoparticles (MSN) were prepared and functionalized to serve as a robust and biocompatible delivery platform for platinum-acridine (PA) anticancer agents. The...
10420818 Methods of treating incontinence and other sphincter deficiency disorders  
A method of treating a sphincter deficiency disorder (e.g., incontinence; gastrointestinal disorders) is carried out by administering stromal cell-derived factor 1 (SDF-1) to a sphincter or...
US20190282510 METHOD OF ENCAPSULATING CELLS USING A MICROFLUIDIC ENCAPSULATION DEVICE  
The present disclosure describes a method of encapsulating cells in a crosslinked alginate microbead using a microfluidic encapsulation device.
US20190271042 IDENTIFICATION OF UNIQUE GENE EXPRESSION PROFILES IN CHILDREN WITH REGRESSIVE AUTISM SPECTRUM DISORDER (ASD) AND ILEOCOLITIS  
The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique gene...
10398847 Incremental syringe  
An incremental syringe useful for multiple injections of medications like botulinum toxin is provided. The syringe includes detents on the syringe plunger which provide a tactile feeling, a...
10398804 Progenitor cells from urine and methods for using the same  
Provided herein are urine progenitor cells and methods for producing a culture of urine progenitor cells from a urine sample. The cells may be selected based upon the use of a selective cell...
10398739 Encapsulated cells for hormone replacement therapy  
A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the...
US20190250126 NANOPORE ANALYSIS OF GLYCOSAMINOGLYCAN COMPOSITIONS  
In one aspect, methods of biomolecular analysis are described herein. Briefly, a method comprises providing a composition comprising glycosaminoglycans and contacting the composition with a...
10377985 Neural progenitor cell differentiation  
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or...
10377784 Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith  
The present invention relates to the compounds of formula (I), pharmaceutically acceptable salts, and solvates thereof, wherein the various substituents are as defined herein. The compounds,...
US20190241616 ANGIOTENSIN (1-7) ANALOGS AND METHODS RELATING THERETO  
Angiotensin (1-7) analogs are provided. Also provided are methods of making such analogs methods for using analogs as therapeutic compositions such as, for example, treatment cancer.
US20190233502 PNEUMOCOCCAL INHIBITORY FACTOR COMPOSITIONS AND METHODS OF USE THEREOF  
An isolated or recombinant aminopeptidase N (pepN) polypeptide having inflammatory cytokine production and cytolysis inhibiting activity is provided. A method of inhibiting inflammatory cytokine...
US20190209695 Pharmaceutical Compositions for High-Capacity Targeted Delivery  
Provided herein are aptamers and pharmaceutical compositions comprising the same. In some embodiments, the aptamer selectively binds a protein of interest such as an extracellular receptor protein...
US20190203038 COMPOSITION WITH POLYMER AND CERAMIC AND METHODS OF USE THEREOF  
Provided herein are improved compositions and methods of making and using the same, the composition comprising a polymer and a ceramic present at a ratio of from 3:1 to 1:3 of polymer:ceramic by...
US20190194625 BLOOD BRAIN BARRIER MODEL AND METHODS OF MAKING AND USING THE SAME  
Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and...
US20190194401 COMPOSITION WITH POLYMER AND CERAMIC AND METHODS OF USE THEREOF  
Provided herein are improved compositions and methods of making and using the same, the composition comprising a polymer and a ceramic present at a ratio of from 3:1 to 1:3 of polymer:ceramic by...
US20190193923 Solid Particulate Measuring Devices, Systems, And Methods  
Solid particulate measuring devices, systems, and methods for using the devices and systems are provided for easier and more accurate measurement of specific volumes. For example, a specific dose...
US20190192282 MEDICAL KITS AND METHODS FOR SMALL INCISION EYE SURGERY  
Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible...
D852375 Cell collection and centrifuge tube assembly  
US20190187129 CANCER MODELING PLATFORMS AND METHODS OF USING THE SAME  
Described herein are in vitro cell constructs (or “organoids”) useful as a tumor model, the constructs comprising live tumor cells from a subject. In some embodiments, provided are in vitro cell...
US20190183958 GRAPE EXTRACTS AND METHODS OF RELATING THERETO  
Provided are liquid and powder grape extracts having elevated phenolic content. The extracts can be made from grape seeds, grape skins, or a combination thereof. In some instances, extracts may be...
10309956 Process for assessing risk of substance administration  
A process for assessing risk that administration of a substance will suppress immune competence in a population of subjects is provided. Such a substance may be a substance related to, contained...
US20190153382 INK-JET PRINTING OF TISSUES  
A method of forming an array of viable cells is carried out by ink-jet printing a cellular composition containing said cells on a substrate. At least two different types of viable mammalian cells...
US20190153057 MULTI-LEVEL SPECIFIC TARGETING OF CANCER CELLS  
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more...
US20190143004 COATINGS AND BIOMEDICAL IMPLANTS FORMED FROM KERATIN BIOMATERIALS  
Methods are provided to produce optimal fractionations of charged keratins that have superior biomedical activity. Also provided are medical implants coated with these keratin preparations....
10283002 Apparatus, methods, and systems for target-based assessment and training for ultrasound-guided procedures  
Ultrasound-guided needle procedures require skills that are challenging to master, especially considering the need to manipulate 3-D structures while observing 2-D images (or even 3-D images). A...
10280463 Identification of unique gene expression profiles in children with regressive autism spectrum disorder (ASD) and ileocolitis  
The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique gene...
US20190127884 Vascular Constructs  
The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and...
10273299 Antibodies to tumor endothelial marker 8  
The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal...
10272088 FAS inhibitors and methods associated therewith  
The present invention relates to compounds, compositions and methods comprising nanoparticles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that...
US20190112660 IDENTIFICATION OF UNIQUE BLOOD-BASED GENE EXPRESSION PROFILES IN CHILDREN WITH REGRESSIVE AUTISM SPECTRUM DISORDER (ASD) AND ILEOCOLITIS  
The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique...
US20190111088 Amniotic Membrane Hydrogel and Methods of Making  
The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain...
10258461 Medical kits and methods for small incision eye surgery  
Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible...
US20190106673 BIOINK COMPOSITIONS AND METHODS OF PREPARING AND USING THE SAME  
Described herein are bioink compositions, which may have an elastic modulus similar to a natural tissue and/or tunable mechanical properties, along with methods of preparing and using the...
10256407 Organic thin film transistors  
In one aspect, organic thin film transistors are described herein. In some embodiments, an organic thin film transistor comprises a source terminal, a drain terminal and a gate terminal; a...
10251915 Co-encapsulation of live cells with oxygen-generating particles  
Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and...
US20190103539 THERMOELECTRIC PIEZOELECTRIC GENERATOR  
Electric generators are described herein integrating thermoelectric and piezoelectric components. In some embodiments, an electric generator comprises a thermoelectric film having a plurality of...
10233224 Nucleic acids encoding a fusion protein useful for multi-level specific targeting of cancer cells  
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more...
US20190070583 lON SEPARATION MEDIA AND APPLICATIONS THEREOF  
Ion separation media are described herein employing thermoelectric materials and architectures. In some embodiments, an ion separation medium comprises a layer of inorganic nanoparticles having a...
10219895 Nanofiber-based graft for heart valve replacement and methods of using the same  
Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
US20190060234 Liposomal Formulations of Platinum-Acridine Anticancer Agents and Methods Thereof  
This invention relates to use of a platinum-acridine liposomal formulation and uses thereof in treating cancer in a subject.
10213533 Medical tools with aspiration tips suitable for cataract surgeries and related methods  
Devices and methods for cataract surgery include a tip with reciprocating door to chop, fragment or reduce size of large nuclear lens fragments and/or cortex fragments in a capsule bag to...
US20190053922 NON-MIGRATING STENT DEVICES AND METHODS  
Non-migrating stent devices and methods for using the devices are provided for treatment of visceral anastomosis strictures or vascular ostium high grade stenosis. For example, placement of a...