Patents and Patent Applications from Wake Forest University


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9828637 Methods of predicting predisposition to or risk of kidney disease  
Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject, e.g.,...
US20170333177 BIOREACTOR SYSTEM AND METHOD OF ENHANCING FUNCTIONALITY OF MUSCLE CULTURED IN VITRO  
A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically...
US20170322206 INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS  
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with...
9801723 Prosthetic penile implants with tethered rear tip extenders and related methods  
Rear tip extenders having a tether attached to a collar for penile implants that can be mounted onto a respective cylinder forward of a fluid line (that communicates with a scrotal pump) to...
9801713 Production of tissue engineered heart valves  
The invention is directed to methods for preparing artificial heart valves by preconditioning a matrix seeded with endothelial cells and smooth muscle cells differentiated from isolated progenitor...
US20170307598 TISSUE-MIMICKING HYDROGEL COMPOSITIONS FOR BIOFABRICATION  
An extrudable hydrogel composition useful for making a three-dimensional organ construct includes a cross-linkable prepolymer, a post-deposition crosslinking group, optionally, an initiator that...
US20170304433 VACCINE COMPOSITIONS AND METHODS OF USE TO TREAT NEONATAL SUBJECTS  
The presently disclosed subject matter relates to the fields of pharmacology and medicine, and provides vaccine compositions and methods of use, particularly influenza compositions and methods of...
US20170291017 SUBDURAL DRAINAGE CATHETER WITH SELF CONTAINED MECHANISM FOR RESTORATION OF FLOW FOLLOWING CATHETER OBSTRUCTION  
A subdural drainage device includes a subdural drainage housing defining a drainage passageway. The drainage passageway has a A subdural drainage device includes a subdural drainage housing...
US20170290950 SYNTHESIS AND USE OF POLY(GLYCEROL-SEBACATE) FILMS IN FIBROBLAST GROWTH REGULATION  
Wound repair materials and methods of using the same to inhibit excess fibrosis are disclosed.
US20170281673 USE OF NITRITE SALTS FOR THE TREATMENT OF CARDIOVASCULAR CONDITIONS  
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial,...
9775866 Co-encapsulation of live cells with oxygen-generating particles  
Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and...
9771404 Multi-level specific targeting of cancer cells  
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more...
9765103 Cleavable conjugates of functionalized platinum-acridine and platinum-benzacridine agents and methods thereof  
The present invention relates to using a versatile synthetic approach to generate a new class of ester, amido, or carbamate prodrugs of highly potent, but systemically too toxic, platinum-acridine...
9764516 Integrated organ and tissue printing methods, system and apparatus  
A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b)...
9763986 Encapsulated cells for hormone replacement therapy  
A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the...
9757225 Bioreactor system and method of enhancing functionality of muscle cultured in vitro  
A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically...
9746466 Integrated compound discovery systems and methods  
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with...
US20170239332 Regeneration of Inner Ear Cells  
The invention provides compositions and methods for treating or preventing hearing loss in a subject. The method comprises administering to the subject in need thereof, at least Myc or an agent...
9737455 Apparatus and method for wound treatment employing periodic sub-atmospheric pressure  
A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound...
9732389 Methods and compositions for correlating genetic markers with prostate cancer risk  
The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and...
US20170227430 Compositions and Methods for Clearing a Biological Sample  
The disclosure provides improved materials and methods for optically clearing biological tissue that is subsequently used for deep tissue imaging analysis. Also provided is a description of a...
9728725 Light emmiting device comprising conjugated terpolymer/teroligomer capable of white light emittion  
In some embodiments, conjugated polymers and oligomers are described herein, which can demonstrate white light or substantially white light emission, thereby reducing or precluding reliance on...
9726683 Methods for predicting risk of coronary stenosis  
A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one...
US20170210772 Cleavable Conjugates of Functionalized Platinum-Acridine and Platinum-Benzacridine Agents and Methods Thereof  
The present invention relates to using a versatile synthetic approach to generate a new class of ester, amido, or carbamate prodrugs of highly potent, but systemically too toxic, platinum-acridine...
9713501 Orbicular tissue expander  
Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized...
US20170203004 AMNIOTIC MEMBRANE POWDER AND ITS USE IN WOUND HEALING AND TISSUE ENGINEERING CONSTRUCTS  
The present invention includes compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane powder. The compositions of...
US20170202982 Hyaluronic Acid-Based Nanoparticles as Biosensors for Imaging-Guided Surgery and Drug Delivery Vehicles and Methods Associated Therewith  
The present invention relates to intraoperative fluorescent imaging (IFI) used both pre-clinically using in-vivo models, as well as clinically to map sentinel lymph nodes in breast cancer, skin...
9707256 Methods of making endothelial scaffolds  
Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells...
9700581 Urine stem cells for skeletal muscle generation and uses thereof  
Provided herein are methods of treating a subject in need of treatment for a urological condition including administering urine stem cells to said subject in a treatment effective amount; and, in...
9700578 Use of nitrite salts for the treatment of cardiovascular conditions  
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial,...
9694055 Renal tissue regeneration  
The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic...
US20170175206 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH RISK OF AGGRESSIVE PROSTATE CANCER  
The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of...
9679672 Low band gap conjugated polymeric compositions and applications thereof  
In one aspect, electrically conductive conjugated polymeric compositions are described herein demonstrating compatibility with aqueous solvents and/or phases. The ability to provide aqueous...
9675646 Tubular bioengineered smooth muscle structures  
Methods of generating tubular, bioengineered, smooth muscle structures are disclosed as well as bioengineered tissue for tubular organ repair or replacement. The methods can include the steps of...
9675637 Use of nitrite salts for the treatment of cardiovascular conditions  
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial,...
9675358 Conduit for peripheral nerve replacement  
A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits...
9671301 Small-scale pressure sensors  
The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest...
9669175 Devices with mouthpieces that allow for rapid change out of endotracheal (ET) tubes and related methods  
Tracheal assembly devices include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a cutting blade in communication with an outwardly...
US20170152568 METHODS AND COMPOSITIONS FOR DETERMINING INDICATION FOR PROSTATE BIOPSY  
The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a...
US20170152565 METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
US20170151435 Methods and Devices for Improving Cognitive Function  
The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a...
US20170151240 F10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy  
Chemotherapy remains of limited use for the treatment of prostate cancer with only one drug, docetaxel, demonstrating a modest survival advantage for treatment of late-stage disease. Data from the...
9663824 Compositions and methods for epigenetic regulation of long chain polyunsaturated fatty acid production  
Compositions and methods for identifying and treating patients having altered capacity for LC-PUFA production are disclosed.
US20170143967 CHOLINERGIC DEEP BRAIN STIMULATOR  
A cholinergic deep brain stimulator is provided that can be used to increase brain acetylcholine levels. This increase in acetylcholine levels improves cognition and may be used to remediate...
US20170128497 CO-ENCAPSULATION OF LIVE CELLS WITH OXYGEN-GENERATING PARTICLES  
Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and...
US20170112905 SYSTEMIC GENE REPLACEMENT THERAPY FOR TREATMENT OF X-LINKED MYOTUBULAR MYOPATHY (XLMTM)  
The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function,...
US20170107483 METHOD OF PRODUCING IN VITRO TESTICULAR CONSTRUCTS AND USES THEREOF  
A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct,...
US20170106050 METHODS OF TREATING INCONTINENCE AND OTHER SPHINCTER DEFICIENCY DISORDERS  
A method of treating a sphincter deficiency disorder (e.g., incontinence; gastrointestinal disorders) is carried out by administering stromal cell-derived factor 1 (SDF-1) to a sphincter or...
US20170096636 METHODS AND COMPOUNDS FOR PHOTOTHERAPY WITH CHALCOGENORHODAMINE PHOTOSENSITIZERS  
A method of selectively depleting pathogenic T lymphocytes from a blood cell composition is carried out by (a) combining the cell composition ex vivo with an active compound in an effective...
US20170095630 Oxygen Port Nasal Cannula  
A device for use in delivering oxygen to a human patient while measuring carbon dioxide exhaled from that patient, comprises: (a) a base member having an oxygen delivery inlet port and a carbon...