Patents and Patent Applications from Wake Forest University


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US20180175312 THIN-FILM PN JUNCTIONS AND APPLICATIONS THEREOF  
In one aspect, composite materials including a thin-film layer of lateral p-n junctions are described herein, which can be employed in circuits or various components of electrical devices....
9993630 Subdural drainage catheters with self contained mechanism for restoration of flow following catheter obstruction  
A subdural drainage system includes: (a) a subdural drainage device having an opening formed therethrough, said subdural drainage device having an upper portion, a body portion, and a lower...
9993505 Innervation of engineered structures  
Methods of generating an innervated muscle structures are disclosed as well as bioengineered structures for tissue repair or regeneration. The methods can include the steps of obtaining...
US20180159036 METHOD OF MAKING AN ORGANIC THIN FILM TRANSISTOR  
In one aspect, organic thin film transistors are described herein. In some embodiments, an organic thin film transistor comprises a source terminal, a drain terminal and a gate terminal; a...
US20180155684 Neural Progenitor Cell Differentiation  
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or...
US20180155437 ANTIBODIES AGAINST HUMAN AND CANINE IL-13RA2  
Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and...
US20180153616 METHODS OF TREATING CANCEROUS TISSUE  
In one aspect, methods of treating cancerous tissue are described herein. In some embodiments, a method of treating cancerous tissue comprises inducing necrotic cell death in cancer stem cells in...
US20180140678 Directed Stem Cell Recruitment  
The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic...
US20180140666 FLAGELLIN FUSION PROTEINS AND CONJUGATES COMPRISING PNEUMOCOCCUS ANTIGENS AND METHODS OF USING THE SAME  
The present invention is based, in part, on flagellin adjuvant used to enhance immune responses directed against Streptococcus pneumoniae, in particular, to enhance immune responses to polypeptide...
9975942 EPHA3 And multi-valent targeting of tumors  
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule...
9974830 Molecular signature of cancer  
The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
US20180133422 DEVICES THAT ALLOW FOR RAPID CHANGE OUT OF ENDOTRACHEAL (ET) TUBES AND RELATED METHODS  
Tracheal tube devices include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a handle holding a cutting member. The mouthpiece can...
9968706 Nerve regeneration employing keratin biomaterials  
A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
9968705 Bioscaffolds for formation of motor endplates and other specialized tissue structures  
Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or...
9968550 Topical wound treatment method and composition  
A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and...
US20180126013 RADIOTHERAPEUTIC AND COMPANION IMAGING AGENTS TO TARGET MC1R  
The subject matter disclosed herein relates generally to cancer therapy and to anti-cancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents...
9962466 Muscle tissue regeneration using muscle fiber fragments  
The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers...
9962160 Surgical staplers with tissue protection and related methods  
Surgical staplers include: (a) a stapler head having opposed first and second elongate jaws with opposing proximal and distal end portions; (b) a staple cartridge held in at least one of the first...
US20180117087 STEM CELLS FROM URINE AND METHODS FOR USING THE SAME  
Provided herein are stem cells and methods for producing a culture of stem cells from urine. The stem cells may be differentiated into an osteogenic, chondrogenic, adipogenic, endothelial,...
US20180105880 METHODS OF PREDICTING PREDISPOSITION TO OR RISK OF KIDNEY DISEASE  
Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject. The...
9938502 Tissue-specific extracellular matrix with or without tissue protein components for cell culture  
The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a...
US20180093016 Tissue-Engineered Bowel Constructs  
Methods are disclosed for forming tissue engineered, tubular bowel constructs from intestinal circular smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells...
9931434 Injectable silk fibroin particles and uses thereof  
The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such...
9905810 Frequency dependent light emitting devices  
An electroluminescent device described herein, in one aspect, comprises a first electrode and second electrode and a light emitting layer positioned between the first and second electrodes. A...
9896656 Neural progenitor cell differentiation  
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or...
9895426 Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM)  
The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function,...
US20180038875 METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES  
Described herein are methods of identifying a mammal having a neurological disease or disorder, such as AD or MCI, or at risk for developing a neurological disease or disorder, such as AD or MCI....
9882128 Method of making an organic thin film transistor  
In one aspect, organic thin film transistors are described herein. In some embodiments, an organic thin film transistor comprises a source terminal, a drain terminal and a gate terminal; a...
9879278 Non-viral episomal suicide construct  
The invention includes compositions and methods for the selective expression of a target gene in a subset of cells. In certain embodiments, the present invention includes a construct comprising a...
9878013 IL-13 receptor binding peptides  
A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at...
9868788 Antibodies against human and canine IL-13RA2  
Provided herein is an antibody (e.g., an isolated antibody) that specifically binds an epitope (e.g., linear epitope) within amino acids spanning the extracellular portion of human IL-13RA2. In...
9865051 Vascular territory segmentation using mutual clustering information from image space and label space  
Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an...
9862924 Neural progenitor cell differentiation  
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or...
9861764 Needle guides suitable for penile injections and related kits  
Embodiments of the invention provide needle guides that facilitate direct penile injection of drug therapies.
US20180002394 MULTI-LEVEL SPECIFIC TARGETING OF CANCER CELLS  
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more...
US20180002275 HYPDH INHIBITORS AND METHODS OF USE FOR THE TREATMENT OF KIDNEY STONES  
Provided herein are compounds of Formula (I), Formula (II), and Formula (III), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation...
US20180000743 Modified Alginate Hydrogels for Therapeutic Agents, their Preparation and Methods Thereof  
A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an...
US20170368743 INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS  
A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b)...
US20170368242 DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE  
The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of...
US20170360789 FAS Inhibitors and Methods Associated Therewith  
The present invention relates to compounds, compositions and methods comprising nanoparticles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that...
US20170354763 MULTI-LAYER SKIN SUBSTITUTE PRODUCTS AND METHODS OF MAKING AND USING THE SAME  
Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy,...
US20170354691 CO-ENCAPSULATION OF LIVE CELLS WITH OXYGEN-GENERATING PARTICLES  
Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and...
9839677 Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM)  
The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function,...
9828637 Methods of predicting predisposition to or risk of kidney disease  
Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject, e.g.,...
US20170333177 BIOREACTOR SYSTEM AND METHOD OF ENHANCING FUNCTIONALITY OF MUSCLE CULTURED IN VITRO  
A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically...
US20170322206 INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS  
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with...
9801723 Prosthetic penile implants with tethered rear tip extenders and related methods  
Rear tip extenders having a tether attached to a collar for penile implants that can be mounted onto a respective cylinder forward of a fluid line (that communicates with a scrotal pump) to...
9801713 Production of tissue engineered heart valves  
The invention is directed to methods for preparing artificial heart valves by preconditioning a matrix seeded with endothelial cells and smooth muscle cells differentiated from isolated progenitor...
US20170307598 TISSUE-MIMICKING HYDROGEL COMPOSITIONS FOR BIOFABRICATION  
An extrudable hydrogel composition useful for making a three-dimensional organ construct includes a cross-linkable prepolymer, a post-deposition crosslinking group, optionally, an initiator that...
US20170304433 VACCINE COMPOSITIONS AND METHODS OF USE TO TREAT NEONATAL SUBJECTS  
The presently disclosed subject matter relates to the fields of pharmacology and medicine, and provides vaccine compositions and methods of use, particularly influenza compositions and methods of...