Patents and Patent Applications from Wake Forest University


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10076318 Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage  
A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
US20180256647 Innervation Of Engineered Structures  
Methods of generating an innervated muscle structures are disclosed as well as bioengineered structures for tissue repair or regeneration. The methods can include the steps of obtaining...
10071076 Methods of treating cancer and other disorders  
Active compounds useful for inhibiting fatty acid synthase in a subject in need thereof are described. The active compounds are, in general, a 5-mercapto-1H-Indazole-4,7-dione or an analog...
US20180248144 FREQUENCY DEPENDENT LIGHT EMITTING DEVICES  
Electroluminescent devices are described herein having structure and design permitting color of emitted light to vary as a function of applied alternating current voltage frequency. Such...
US20180244745 EPHA3 AND MULTI-VALENT TARGETING OF TUMORS  
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule...
US20180243368 MOLECULAR SIGNATURE OF CANCER  
The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
10058452 One-card presbyopia systems and related methods  
Methods and systems for correcting presbyopia using a surgical excimer laser include activating the laser once and transmitting a pre-defined three dimensional ablation profile to treat presbyopia...
US20180236131 BIOSCAFFOLDS FOR FORMATION OF MOTOR ENDPLATES AND OTHER SPECIALIZED TISSUE STRUCTURES  
Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or...
10052350 Fabrication of gelatin hydrogel sheet for the transplantation of corneal endothelium  
The invention provides a corneal endothelial composition comprising a transparent hydrogel scaffold and a single layer of cultured corneal endothelial cells on the surface of the scaffold. The...
10047057 Functionalized tyrosine kinase inhibitors modified with precious metal electrophiles and methods associated therewith  
Newly synthesized thiourea-modified 3-chloro-4-fluoroanilino-quinazoline derivatives have been studied as terminal carrier ligands in linear gold(I) complexes. The molecules mimic the tyrosine...
US20180225821 VASCULAR TERRITORY SEGMENTATION USING MUTUAL CLUSTERING INFORMATION FROM IMAGE SPACE AND LABEL SPACE  
Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an...
US20180214614 VASCULAR CAST-BASED SCAFFOLDS AND METHODS OF MAKING THE SAME  
The present application relates to biomimetic three-dimensional (3D) scaffolds, constructs and methods of making the same. The three-dimensional scaffold can include a sacrificial internal cast...
US20180214604 MUSCLE TISSUE REGENERATION USING MUSCLE FIBER FRAGMENTS  
The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers...
US20180208994 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH PROSTATE CANCER RISK  
The present invention provides a method of identifying a subject as having an increased risk of developing prostate cancer, comprising detecting in the subject the presence of various...
US20180202993 BIOENERGETIC PROFILING OF CIRCULATING BLOOD CELLS AND SYSTEMS, DEVICES, AND METHODS RELATING THERETO  
The invention relates generally to systems and methods of bioenergetic profiling, uses thereof, and systems and devices relating thereto. In particular, methods of the invention are useful in...
10023599 Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith  
The present invention relates to the compounds of formula I, pharmaceutically acceptable salts, and solvates thereof: wherein the various substituents are as defined herein. The compounds,...
10017768 Method of treatment of chlamydial infections with selected EGFR inhibitors  
The present invention provides compositions and methods of use in the treatment/prevention of chlamydial infection and/or diseases and disorders associated with chlamydial infection in a subject.
10016464 Amniotic membrane hydrogel and methods of making  
The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain...
US20180190945 FREQUENCY DEPENDENT LIGHT EMITTING DEVICES  
An electroluminescent device described herein, in one aspect, comprises a first electrode and second electrode and a light emitting layer positioned between the first and second electrodes. A...
US20180187265 METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH PROSTATE CANCER RISK  
The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and...
US20180175312 THIN-FILM PN JUNCTIONS AND APPLICATIONS THEREOF  
In one aspect, composite materials including a thin-film layer of lateral p-n junctions are described herein, which can be employed in circuits or various components of electrical devices....
9993630 Subdural drainage catheters with self contained mechanism for restoration of flow following catheter obstruction  
A subdural drainage system includes: (a) a subdural drainage device having an opening formed therethrough, said subdural drainage device having an upper portion, a body portion, and a lower...
9993505 Innervation of engineered structures  
Methods of generating an innervated muscle structures are disclosed as well as bioengineered structures for tissue repair or regeneration. The methods can include the steps of obtaining...
US20180159036 METHOD OF MAKING AN ORGANIC THIN FILM TRANSISTOR  
In one aspect, organic thin film transistors are described herein. In some embodiments, an organic thin film transistor comprises a source terminal, a drain terminal and a gate terminal; a...
US20180155684 Neural Progenitor Cell Differentiation  
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or...
US20180155437 ANTIBODIES AGAINST HUMAN AND CANINE IL-13RA2  
Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and...
US20180153616 METHODS OF TREATING CANCEROUS TISSUE  
In one aspect, methods of treating cancerous tissue are described herein. In some embodiments, a method of treating cancerous tissue comprises inducing necrotic cell death in cancer stem cells in...
US20180140678 Directed Stem Cell Recruitment  
The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic...
US20180140666 FLAGELLIN FUSION PROTEINS AND CONJUGATES COMPRISING PNEUMOCOCCUS ANTIGENS AND METHODS OF USING THE SAME  
The present invention is based, in part, on flagellin adjuvant used to enhance immune responses directed against Streptococcus pneumoniae, in particular, to enhance immune responses to polypeptide...
9975942 EPHA3 And multi-valent targeting of tumors  
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule...
9974830 Molecular signature of cancer  
The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
US20180133422 DEVICES THAT ALLOW FOR RAPID CHANGE OUT OF ENDOTRACHEAL (ET) TUBES AND RELATED METHODS  
Tracheal tube devices include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a handle holding a cutting member. The mouthpiece can...
US20180133331 Site-Specific DNA-Doxorubicin Conjugates Display Enhanced Cytotoxicity to Breast Cancer Cells  
Doxorubicin (Dox) is widely used for breast cancer treatment but causes serious side-effects including cardiotoxicity that may adversely impact patient lifespan even if treatment is successful....
9968706 Nerve regeneration employing keratin biomaterials  
A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
9968705 Bioscaffolds for formation of motor endplates and other specialized tissue structures  
Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or...
9968550 Topical wound treatment method and composition  
A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and...
US20180126013 RADIOTHERAPEUTIC AND COMPANION IMAGING AGENTS TO TARGET MC1R  
The subject matter disclosed herein relates generally to cancer therapy and to anti-cancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents...
9962466 Muscle tissue regeneration using muscle fiber fragments  
The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers...
9962160 Surgical staplers with tissue protection and related methods  
Surgical staplers include: (a) a stapler head having opposed first and second elongate jaws with opposing proximal and distal end portions; (b) a staple cartridge held in at least one of the first...
US20180117087 STEM CELLS FROM URINE AND METHODS FOR USING THE SAME  
Provided herein are stem cells and methods for producing a culture of stem cells from urine. The stem cells may be differentiated into an osteogenic, chondrogenic, adipogenic, endothelial,...
US20180105880 METHODS OF PREDICTING PREDISPOSITION TO OR RISK OF KIDNEY DISEASE  
Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject. The...
9938502 Tissue-specific extracellular matrix with or without tissue protein components for cell culture  
The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a...
US20180093016 Tissue-Engineered Bowel Constructs  
Methods are disclosed for forming tissue engineered, tubular bowel constructs from intestinal circular smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells...
9931434 Injectable silk fibroin particles and uses thereof  
The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such...
9905810 Frequency dependent light emitting devices  
An electroluminescent device described herein, in one aspect, comprises a first electrode and second electrode and a light emitting layer positioned between the first and second electrodes. A...
9896656 Neural progenitor cell differentiation  
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or...
9895426 Systemic gene replacement therapy for treatment of X-linked myotubular myopathy (XLMTM)  
The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function,...
US20180038875 METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES  
Described herein are methods of identifying a mammal having a neurological disease or disorder, such as AD or MCI, or at risk for developing a neurological disease or disorder, such as AD or MCI....
9882128 Method of making an organic thin film transistor  
In one aspect, organic thin film transistors are described herein. In some embodiments, an organic thin film transistor comprises a source terminal, a drain terminal and a gate terminal; a...
9879278 Non-viral episomal suicide construct  
The invention includes compositions and methods for the selective expression of a target gene in a subset of cells. In certain embodiments, the present invention includes a construct comprising a...