Patents and Patent Applications from WARF University of Wisconsin Madison


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US20180202939 Visible Detection of Microorganisms  
Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25...
US20180201972 ENHANCED THROUGHPUT MINERAL COATINGS FOR OPTIMIZATION OF STEM CELL BEHAVIOR  
Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular...
US20180201961 PRODUCTION OF POLYHYDROXYALKANOATES WITH A DEFINED COMPOSITION FROM AN UNRELATED CARBON SOURCE  
Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a PHA polymerase gene, a thioesterase...
US20180201593 ELECTRONICALLY ACTIVATED STRAINED ALKYNES  
Compounds of Formula I: wherein:R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or...
US20180201524 BISMUTH-BASED CHLORIDE-STORAGE ELECTRODES  
Bismuth-based, chloride-storage electrodes and rechargeable electrochemical cells incorporating the chloride-storage electrodes are provided. Also provided are methods for making the electrodes...
US20180200251 METHODS FOR TREATING COGNITIVE DEFICITS ASSOCIATED WITH FRAGILE X SYNDROME  
Provided herein are methods of treating a cognitive deficit, including cognitive deficits associated with a Fmr1 genetic defect. More particularly, provided herein are methods in which an...
10024870 Therapeutic and diagnostic methods and compositions for neurodegenerative diseases  
Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes...
10022450 Regulation of specific spinal neurons regulating pain transmission via chimeric toxins  
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the...
10020717 Dual stator, flux switching permanent magnet machine  
An electric machine includes a rotor, a first stator, and a second stator. The rotor includes a rotor core and a first and a second plurality of poles mounted to extend radially from the rotor...
10017771 Construction of a quadruple enterotoxin-deficient mutant of bacillus thuringiensis  
Some HBL and NHE enterotoxins are known to cause food-borne diseases in humans. Enterotoxin-deficient mutants of member strains of the Bacillus cereus group that do not produce HBL, HBLa1, HBLa2,...
10017569 Interleukin-10 peptides and antibodies thereof for inhibiting adverse effects of protozoan infection  
The present disclosure is directed to interleukin-10 (IL-10) peptides and isolated antibodies that specifically bind to the IL-10 peptides. The IL-10 peptides and the isolated antibodies may be...
US20180187227 RNA-MEDIATED GENE ASSEMBLY FROM DNA OLIGONUCLEOTIDES  
The present invention is directed to methods and materials for RNA-mediated gene assembly from oligonucleotide sequences. In some embodiments, the oligonucleotides used for gene assembly are...
US20180185408 ANTIFUNGAL NYLON-3 POLYMERS AND COMBINATION THERAPY USING THEM TO TREAT FUNGAL INFECTIONS  
A method and corresponding pharmaceutical composition for inhibiting the growth of fungi. The method uses an antifungal composition containing as the active ingredient one or more nylon-3...
US20180185278 COMPOSITIONS CONTAINING PREEN OIL AND METHODS OF USE THEREOF  
Described herein are methods of use of purified preen oil, food and feed compositions containing purified preen oil, food and feed additives containing purified preen oil, and pharmaceutical...
10013780 Systems and methods for artifact removal for computed tomography imaging  
An imaging system includes a computed tomography (CT) acquisition unit and at least one processor. The CT acquisition unit includes an X-ray source and a CT detector configured to collect CT...
10013048 Reconfigurable event driven hardware using reservoir computing for monitoring an electronic sensor and waking a processor  
The present inventors have recognized that proper utilization of reconfigurable event driven hardware may achieve optimum power conservation in energy constrained environments including a low...
10011540 Heterogeneous catalysts for the oxidative dehydrogenation of alkanes or oxidative coupling of methane  
Improved methods of oxidative dehydrogenation (ODH) of short chain alkanes or ethylbenzene to the corresponding olefins, and improved methods of oxidative coupling of methane (OCM) to ethylene...
10010581 Syndecan peptides and polypeptides and uses thereof  
The invention provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit α4β6 interaction with HER2, thereby preventing tumor cell growth and tissue invasion....
US20180182911 HYBRID TANDEM SOLAR CELLS WITH IMPROVED TUNNEL JUNCTION STRUCTURES  
Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and...
US20180177856 IMMUNOGENIC COMPOSITIONS AGAINST TUBERCULOSIS  
Methods of preparing mutants of Mycobacterium tuberculosis with one or more disrupted genes are presented, where the disrupted genes include ctpV, rv0990c, rv0971c, and/or rv0348. Compositions...
10007961 Treatment planning system for radiopharmaceuticals  
A treatment schedule for radiopharmaceuticals is developed by collecting a volumetric history of tissue uptake in identified volumes of interest using emitted-radiation scans and relating this...
10006057 Recombinant yeast having enhanced gamma valerolactone tolerance and methods of use  
The present invention relates to materials and methods for the production of ethanol. More particularly, the present invention provides genetically modified strains of Saccharomyces cerevisiae...
US20180176739 Navigation System Tracking High-Efficiency Indoor Lighting Fixtures  
A system for identifying the location of a mobile device uses signatures of standard room lighting derived from the frequency spectrum of light fluctuations associated with driver circuitry of...
US20180175396 PEROVSKITE COMPOUNDS FOR STABLE, HIGH ACTIVITY SOLID OXIDE FUEL CELL CATHODES AND OTHER APPLICATIONS  
Solid oxide fuel cells (SOFCs) are provided. A SOFC may comprise a cathode, an anode, and a solid oxide electrolyte between the anode and the cathode, wherein the cathode comprises a perovskite...
US20180172977 Optical Phase Shifter  
A optical phase shifter is provided for adjusting an optical phase of light propagating therethrough along an optical axis. The optical phase shifter includes first and second transparent slides...
US20180172598 Packaging and Methods For Detecting Exposure of a Perishable Good to an Elevated Temperature  
Nanoreactors comprising a metal precursor in a carrier are provided. In some embodiments, upon exposure to heat, the metal precursor forms nanoparticles that can be detected, e.g., by detecting a...
US20180170889 Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors  
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One...
US20180170755 Mixed Oxygen and Organic Compound Treatment for Functionalizing Oxygen Onto the Surface of Boron Nitride  
Improved methods of synthesizing oxygen-functionalized boron nitride (O—BN) are disclosed. In the disclosed methods, boron nitride (BN) in any form is contacted with a gaseous composition or...
US20180169224 TLR AGONISTS FOR REDUCING ACTIVATION-INDUCED PD-1 EXPRESSION ON T CELLS AND METHODS OF USE  
The present invention is directed toward methods of increasing the immune response to an antigen using TLR1/2 agonist and/or TLR7 agonist in combination with a T cell activating treatment, for...
US20180169185 SYNDECAN PEPTIDES AND POLYPEPTIDES AS INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR2) AND VERY LATE ANTIGEN-4 (VLA-4)  
The disclosure provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit VLA-4 interaction with VEGFR2, thereby preventing tumor cell growth and tissue invasion.
10003228 Interior permanent magnet machine with axially varying permanent magnet size  
A rotor includes pole portions, a first permanent magnet, a second permanent magnet, and a third permanent magnet. Each pole portion includes a center, a back, and a front rotor core portion. A...
10002445 System and method for resolving artifacts in four-dimensional angiographic data  
A system and method are provided for medical imaging that includes acquiring, during a common imaging acquisition process, rotational, x-ray volume image data and x-ray tomosynthesis image data...
US20180162901 Method For Facilitating Extraction Of A Fraction From A Biological Sample  
A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The method...
9994819 Xeno-free generation of tissue-specific progenitor cells  
The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
9993534 Method of treating fungal infection  
A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a...
9993206 System for characterizing brain condition  
A sensitive measure of brain condition simultaneously evaluates multiple measurements of water diffusion in brain tissue combined so as to correct for covariance between the different data types...
US20180159391 SALIENT POLE, WOUND FIELD, SYNCHRONOUS MACHINE WITH ENHANCED SALIENCY  
A rotor for a salient pole, wound field, synchronous machine includes a rotor core, a plurality of pole bodies, and a field winding. Each pole body of the plurality of pole bodies includes a pole...
US20180155732 CONSTRUCTS AND METHODS FOR GENOME EDITING AND GENETIC ENGINEERING OF FUNGI AND PROTISTS  
Provided herein are constructs for genome editing or genetic engineering its fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a...
US20180155706 Method And Device For Disaggregation Via Heterogeneous Particles  
A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a...
US20180153928 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME  
Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal...
US20180153924 COMPOSITIONS AND METHODS FOR AQUACULTURE  
Methods and compositions for increasing the growth rate of a prey fish are described. A method includes contacting the prey fish with a water-soluble growth promoting factor in an amount effective...
US20180153849 MULTI-DRUG COMBINATIONS THAT ACT AS POTENT RADIOSENSITIZERS  
Provided is a method of treatment including administering to lung, brain or esophageal cancer cells an effective amount of radiation in conjunction with a micelle composition that includes an...
9989613 System and method for externally calibrated parallel imaging in the presence of an inhomogeneous magnetic field  
A system and method for accelerated magnetic resonance imaging (MRI) includes controlling an RF system of an MRI system to acquire coil calibration data from a subject including a material causing...
9988665 Methods for determining protein binding specificity using peptide libraries  
A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase...
9988633 Compositions and methods to promote erythropoiesis  
Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of Exosc10, such as inhibitory nucleic...
9988434 Optimal interstrand bridge for collagen mimics  
Novel collagen-mimetic peptides are disclosed comprising the formula (Xaa-Yaa-Gly)n, where the amino acid at one of the Xaa positions is substituted with a homocysteine residue. Also disclosed are...
US20180147272 Vaccine Candidates Against Johne's Disease  
A composition and method for immunizing a mammal infected with Mycobacterium are disclosed. The genes gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2_2, aceAB, mbtH2, lpqP, map0834c, cspB, lipN, or...
US20180147171 TRANS10:CIS12 ISOMER OF CONJUGATED LINOLEIC ACID AS A THERAPEUTIC AND PREVENTATIVE AGENT FOR HYPERTENSION SPECIFIC TO PREGNANCY  
Described herein are compositions and methods for the use of t10:c12 conjugated linoleic acid to reduce hypertension in pregnant women. Advantageously, by reducing blood pressure, the compositions...
9981312 Three-dimension printer with mechanically scanned cathode-comb  
A 3-D printer scalable to large sizes employs a combination of mechanical and electrical scanning of a linear array of electron beams that operate to melt material of a powder bed. A housing...
US20180142215 Artificial Transcription Factors and Uses Thereof  
The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell...