Patents and Patent Applications from Virginia Commonwealth University


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9777123 Sulfated beta-O4 low molecular weight lignins  
Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.
9773594 Non-rare earth magnetic nanoparticles  
Continuous flow synthetic methods are used to make single phase magnetic metal alloy nanoparticles that do not contain rare earth metals. Soft and hard magnets made from the magnetic nanoparticles...
9771400 Photoactive silk protein and fabrication of silk protein structures using photolithography  
A natural protein, specifically silk fibroin or sericin, is chemically modified such that it can be rendered photoactive, but which otherwise has similar structure and attributes as silk fibroin...
US20170269080 OMPA IN VACCINE COMPOSITIONS AND AS DIAGNOSTIC TARGETS  
Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born...
US20170269048 PORTABLE ALCOHOL TESTER  
A portable electronic alcohol-testing device is provided that uses vaporization and sensitive pressure guages to approximate the alcohol content of a solution. The device may be used, for example,...
D797944 Hands free breastfeeding aid  
9768355 Production of graphene and nanoparticle catalysts supported on graphene using laser radiation  
Methods and apparatuses to produce graphene and nanoparticle catalysts supported on graphene without the use of reducing agents, and with the concomitant production of heat, are provided. The...
9765017 Allosteric hemoglobin modifiers with nitric oxide releasing moiety  
Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the...
9763894 Inflammation therapy  
A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid...
US20170260146 A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION  
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units...
9758459 Allosteric modulators of factor XIa as anticoagulant agents  
Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated...
US20170253648 Compositions and Methods for Prophylaxis and/or Therapy of Disorders that Correlate with DENND1A Variant 2  
Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...
US20170252422 STAGE SPECIFIC DIAGNOSTIC ANTIGENS, ASSAY AND VACCINE FOR LYME DISEASE  
Stage-specific Borrelia antigens for diagnosing, treating and/or preventing Lyme disease are provided. The antigens include chimeric Borrelia antigen constructs and mutant recombinant proteins...
US20170252355 OXYGENATED CHOLESTEROL SULFATES FOR THERAPY OF DISORDERS CAUSED BY AT LEAST ONE OF ATTENUATED LEPTIN ACTIVITY AND A LIPID STORAGE DISORDER  
Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin activity and by lipid storage...
9750823 Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics  
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1...
US20170250444 HALOGEN-FREE ELECTROLYTES  
Compounds (salts) for use as electrolytes, e.g. in batteries such as Li ion, Na ion and Mg ion batteries are provided. The negative ions (anions) of the compounds are complex molecules which do...
9738605 Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders  
Hybrid compounds of curcumin and melatonin as neuroprotectants are provided. The hybrid compounds are useful for the treatment and/or prevention of Alzheimer's disease (AD), as well as other...
US20170224693 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
US20170218160 METHOD FOR ONE-STEP SYNTHESIS, CROSS-LINKING AND DRYING OF AEROGELS  
A method of synthesizing aerogels and cross-linked aerogels in a single step and in a single pot without requiring any solvent exchange is described. Porous matrices are synthesized through a...
US20170209555 Compositions and Methods for Modulating Cardiac Conditions  
Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or...
US20170202941 OMPA AND ASP14 IN VACCINE COMPOSITIONS AND AS DIAGNOSTIC TARGETS  
Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections...
9701985 mda-9/syntenin promoter to image and treat metastatic cancer cells  
Recombinant vectors in which expression of one or more elements (e.g. gene required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by an mda-9/syntenin...
9687037 Magnetic football helmet to reduce concussion injuries  
Helmets which harness magnetic forces to reduce the force of impact collisions to helmets during contact sports, thus reducing the likelihood that athletes sustain a physical injury such as a...
US20170165342 AIPA, OMPA, AND ASP14 IN VACCINE COMPOSITIONS AND DIAGNOSTIC TARGETS FOR ANAPLASMA PHAGOCYTOPHILUM INFECTION  
Anaplasma phagocytophilum surface protein AipA and/or fragments thereof which comprise an invasin domain are used in compositions suitable to elicit an immune response to treat or prevent...
9676844 Pharmaceutical compositions comprising DENND1A variant 2 and methods of use thereof  
Pharmaceutical compositions and methods for the treatment of DENND1 A. V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...
9669198 System and method for intracranial implantation of therapeutic or diagnostic agents  
A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion...
US20170151198 ORGAN PROTECTION SOLUTIONS AND METHOD OF USE  
An organ protectant solution which is intravenously administered includes at least one oncotic agent and optionally a high concentration of cell-impermeant molecules. Together, they promote...
US20170136038 Sulfated-Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Tissue Regeneration  
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol...
9649316 Induction of tumor hypoxia for cancer therapy  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
US20170114106 Lyme Disease Vaccine  
Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease,...
9616033 Selective metabolic approach to increasing oral bioavailability of phenylephrine and other phenolic bioactivities  
Presystemic metabolism in intestine of bioactives such as phenylephrine is avoided by administering a subject (human or animal) the bioactive (e.g., phenylephrine) in combination with one or more...
US20170087363 WIRELESS IMPLANTABLE TASTE SYSTEM  
The system includes various embodiments of components, including (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The...
9598384 3-(2-amino-ethyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-alkylidene-1,3-dihydro-indol-2-one derivatives as selective sphingosine kinase 2 inhibitors  
3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-th iazolidine-2,4-dione and 1-(2-amino-ethyl)-3-alkylidene-1,3-dihydro-indol-2-one and derivatives thereof are provided for use as...
US20170061136 APPLICATION PERMISSION RECOMMENDATION AND CONTROL  
In one example implementation, a method includes receiving, at a computing device, a request to grant a set of requested permissions to an application installed on the computing device, and...
US20170058319 NANOSENSOR FOR ASSESSING THROMBIN INHIBITORS  
Constructs and monitoring systems to assess the level of molecules that bind to thrombin (e.g. thrombin regulators and inhibitors) are provided. The constructs are nanosensors comprising i) a...
US20170049848 Target for Firmicutes and Related Bacteria: The PRP Protease  
L27 in Staphylococcus aureus and other Firmicutes is encoded with an N-terminal extension that is not present in most Gram-negative organisms and is absent from mature ribosomes. We have...
US20170049109 ANTIMICROBIAL POLYMERIC COMPOSITIONS  
A compound having the formula: wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect...
9572909 Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture  
Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and...
9562079 Vaccines and methods to treat lyme disease in dogs  
The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of...
US20170029399 2-SUBSTITUTED-5-HYDROXY-4H-CHROMEN-4-ONES AS NOVEL LIGANDS FOR THE SEROTONIN RECEPTOR 2B (5-HT2B)  
A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively...
9556239 Polyvalent chimeric OSPC vaccinogen and diagnostic antigen  
A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5...
US20170014429 USES OF OXYGENATED CHOLESTEROL SULFATES (OCS)  
Methods of preventing and/or treating ischemia, organ dysfunction and/or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ...
9534021 Lyme disease vaccine  
Antigenic polypeptides comprising linear immunodominant epitopes of Borrelia outer surface protein A (OspA) or Borrelia outer surface protein C (OspC) are useful as vaccines against Lyme disease,...
US20160375270 3D Tracking of an HDR Source Using a Flat Panel Detector  
A method and apparatus are used to compare an intended treatment plan using a radiation source with a delivered plan. This done by arranging markers at known three-dimensional (3D) positions in a...
9527823 Hydroxybupropion analogues for treating drug dependence  
The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may...
US20160368181 DELIVERY OF PARTICLES USING HYGROSCOPIC EXCIPIENTS  
An assembly and methods for providing a contoured biological tissue are described. The assembly comprises a first plate and a second plate. The first plate is configured to receive a biological...
D774700 Radiation protective headwear  
9522179 Compositions and methods for modulating cardiac conditions  
Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or...
US20160366044 RAPID LOCALIZATION PLATFORM FOR LOCATION BASED APPLICATIONS IN SELF-ORGANIZED NETWORKING SYSTEMS  
Time-critical Location Based Service (LBS) applications in mobile ad hoc networks (MANETs) require fast localization. An On-Demand Fast Localization (ODFL) start from multi-coordinate systems, and...
9517342 Olfactory implant system  
The system includes five components: (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The olfactory implant system...