Patents and Patent Applications from Virginia Commonwealth University


Match Document Document Title
10010692 Systems, devices, and methods for changing therapeutic aerosol size and improving efficiency of ventilation and aerosol drug delivery  
A mixer-heater device provides controllable reduction in aerosol droplet size. Additionally, an intermittent delivery mode for administering an aerosol to a patient may take into account patient...
10000453 Chelation directed C—H activation reactions catalyzed by solid-supported palladium(II) catalysts  
Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions...
9994865 PEG-Prom mediated surface expression of avidin/streptavidin  
The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication,...
9974758 Sphingosine kinase type 1 inhibitors and uses thereof  
Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These...
US20180135130 NOVEL METHYLATION SITE REGULATING EXPRESSION OF MDA-9/SYNTENIN  
Methods of prognosing the outcome of cancer and/or cancer treatment are provided. The methods involve quantitating the level of methylation at a site that regulates expression of the...
US20180127457 NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3BETA-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVERS DISEASES AND ATHEROSCLEROSIS  
5-cholesten, 3β,25-diol, disulfate (25HCDS) has been found to be an authentic PPARγ agonist and LXR antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including...
9957567 Methods relating to DENND1A Variant 2 and polycystic ovary syndrome  
Provided are compositions and methods for use in polycystic ovary syndrome diagnosis (PCOS). The method involves a sample from a subject for a DENND1A Variant 2 mRNA or DENND1 A Variant 2 protein...
9951114 Recombinant cancer therapeutic cytokine  
Recombinant therapeutic cytokines (“therakines”) for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 (“M4”) not normally found in nature...
9951020 Methods of making 2-halonicotinonitriles  
A method of making a 2-halonicotinonitrile comprises reacting an alkylidene nitrile with a C1-compound in an organic solvent and a dehydrating agent. The dehydrating agent substantially retards...
US20180105562 IMMUNE MODULATOR FOR IMMUNOTHERAPY AND VACCINE FORMULATION  
A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170...
9945851 OmpA in vaccine compositions and as diagnostic targets  
Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born...
9944597 Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof  
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic...
9943347 Medial column (MECO) fixation device, method, and system  
An orthopedic implant device and system support the fusion of bones in the medial column of the human foot. An exemplary implant uses an improved lag screw and supplemental components, including a...
9931125 Device for control of difficult to compress hemorrhage  
Bleeding from blood vessels located in difficult-to-compress regions of the body (especially the abdomen, pelvic or groin region) is controlled by the use of a portable, small-footprint belt-like...
9926589 Identification and quantification of multiple nucleic acid targets in complex mixtures  
A complex mixture is analyzed for multiple nucleic acid sequences (e.g., DNA or RNA sequences) simultaneously by target specific multiplex amplification followed by single molecule detection of...
US20180064931 DEVICES AND METHODS FOR REPAIRING DAMAGE TO A NERVE  
An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of...
9906431 Rapid localization platform for location based applications in self-organized networking systems  
Time-critical Location Based Service (LBS) applications in mobile ad hoc networks (MANETs) require fast localization. An On-Demand Fast Localization (ODFL) start from multi-coordinate systems, and...
US20180050039 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
US20180043585 DELIVERY OF PARTICLES USING HYGROSCOPIC EXCIPIENTS  
A method of delivering a therapeutic agent comprises providing an aerosol generator that produces an aerosol of particles or droplets containing a therapeutic agent and an excipient for delivery...
9884836 2-substituted-5-hydroxy-4H-chromen-4-ones as novel ligands for the serotonin receptor 2B (5-HT2B)  
A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively...
9850221 Sulfated and unsulfated flavonoid oligomers as cancer therapeutics  
Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and...
US20170362181 CHELATION DIRECTED C-H ACTIVATION REACTIONS CATALYZED BY SOLID-SUPPORTED PALLADIUM(II) CATALYSTS  
Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions...
US20170360562 Three-Dimensional Pre-Vascularized Scaffold for Bone Regeneration  
The present invention provides scaffolds comprising dual structural organization for bone and regeneration. Methods for fabricating and using the scaffold are also disclosed.
9822154 Immune modulator for immunotherapy and vaccine formulation  
A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170...
9821084 Hemostasis of wound having high pressure blood flow using kaolin and bentonite  
Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when...
US20170326086 USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES  
Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas...
US20170313828 IN SITU-FORMING OF DENDRIMER HYDROGELS USING MICHAEL-ADDITION REACTION  
A method of forming a dendrimer hydrogel, the method comprising providing one or more amine end-functioned polyamidoamine (PAMAM) as a first reactant; providing one or more small molecule,...
9777123 Sulfated beta-O4 low molecular weight lignins  
Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.
9773594 Non-rare earth magnetic nanoparticles  
Continuous flow synthetic methods are used to make single phase magnetic metal alloy nanoparticles that do not contain rare earth metals. Soft and hard magnets made from the magnetic nanoparticles...
9771400 Photoactive silk protein and fabrication of silk protein structures using photolithography  
A natural protein, specifically silk fibroin or sericin, is chemically modified such that it can be rendered photoactive, but which otherwise has similar structure and attributes as silk fibroin...
US20170269080 OMPA IN VACCINE COMPOSITIONS AND AS DIAGNOSTIC TARGETS  
Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born...
US20170269048 PORTABLE ALCOHOL TESTER  
A portable electronic alcohol-testing device is provided that uses vaporization and sensitive pressure guages to approximate the alcohol content of a solution. The device may be used, for example,...
D797944 Hands free breastfeeding aid  
9768355 Production of graphene and nanoparticle catalysts supported on graphene using laser radiation  
Methods and apparatuses to produce graphene and nanoparticle catalysts supported on graphene without the use of reducing agents, and with the concomitant production of heat, are provided. The...
9765017 Allosteric hemoglobin modifiers with nitric oxide releasing moiety  
Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the...
9763894 Inflammation therapy  
A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid...
US20170260146 A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION  
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units...
9758459 Allosteric modulators of factor XIa as anticoagulant agents  
Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated...
US20170253648 Compositions and Methods for Prophylaxis and/or Therapy of Disorders that Correlate with DENND1A Variant 2  
Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...
US20170252422 STAGE SPECIFIC DIAGNOSTIC ANTIGENS, ASSAY AND VACCINE FOR LYME DISEASE  
Stage-specific Borrelia antigens for diagnosing, treating and/or preventing Lyme disease are provided. The antigens include chimeric Borrelia antigen constructs and mutant recombinant proteins...
US20170252355 OXYGENATED CHOLESTEROL SULFATES FOR THERAPY OF DISORDERS CAUSED BY AT LEAST ONE OF ATTENUATED LEPTIN ACTIVITY AND A LIPID STORAGE DISORDER  
Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin activity and by lipid storage...
9750823 Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics  
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1...
US20170250444 HALOGEN-FREE ELECTROLYTES  
Compounds (salts) for use as electrolytes, e.g. in batteries such as Li ion, Na ion and Mg ion batteries are provided. The negative ions (anions) of the compounds are complex molecules which do...
9738605 Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders  
Hybrid compounds of curcumin and melatonin as neuroprotectants are provided. The hybrid compounds are useful for the treatment and/or prevention of Alzheimer's disease (AD), as well as other...
US20170224693 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
US20170218160 METHOD FOR ONE-STEP SYNTHESIS, CROSS-LINKING AND DRYING OF AEROGELS  
A method of synthesizing aerogels and cross-linked aerogels in a single step and in a single pot without requiring any solvent exchange is described. Porous matrices are synthesized through a...
US20170209555 Compositions and Methods for Modulating Cardiac Conditions  
Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or...
US20170202941 OMPA AND ASP14 IN VACCINE COMPOSITIONS AND AS DIAGNOSTIC TARGETS  
Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections...
9701985 mda-9/syntenin promoter to image and treat metastatic cancer cells  
Recombinant vectors in which expression of one or more elements (e.g. gene required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by an mda-9/syntenin...
9687037 Magnetic football helmet to reduce concussion injuries  
Helmets which harness magnetic forces to reduce the force of impact collisions to helmets during contact sports, thus reducing the likelihood that athletes sustain a physical injury such as a...