Patents and Patent Applications from Vanderbilt University


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9870678 Dynamic alarm system for reducing alarm fatigue  
A dynamic alarm system that can assess the background noise in a clinical environment with sub-minute time sampling and change the alarm output to a desired signal-to-noise ratio (SNR) below...
9869675 Low resource processor using surface tension valves for extracting, concentrating, and detecting whole cells  
Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and...
9868746 Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4  
In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric...
9868647 System and methods for removing impurities from phosphogypsum and manufacturing gypsum binders and products  
Methods and systems that remove impurities from phosphogypsum (PG), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, PG is reacted with a...
9867879 Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO)  
A method for treating a microbial infection involves administering an effective amount of a compound of the formula: wherein R1 is H, alkyl, aryl, heteroaryl, R2 is H, halogen, alkyl, aryl,...
US20180005391 SYSTEM AND METHOD FOR CORRECTING DATA FOR DEFORMATIONS DURING IMAGE-GUIDED PROCEDURES  
Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure are provided. The system and method includes obtaining a...
US20180005381 IMAGE SEGMENTATION VIA MULTI-ATLAS FUSION WITH CONTEXT LEARNING  
Systems and methods are provided for segmenting tissue within a computed tomography (CT) scan of a region of interest into one of a plurality of tissue classes. A plurality of atlases are...
9856348 Multifunctional degradable nanoparticles with control over size and functionalities  
In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one...
US20170373434 MULTI-PLATFORM MODULAR DEVICE  
A multi-platform modular device including a plurality of platforms or modules. Each module implements a different function and can be connected to another module via a plurality of magnetic...
US20170369505 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4  
Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine,...
US20170364630 IDENTIFICATION OF CELLULAR ANTIMICROBIAL DRUG TABLETS THROUGH INTERACTOME ANALYSIS  
A method of identifying a promising cellular antiviral or bacterial toxin drug target is described including: 1) providing a plurality of potential antiviral or bacterial toxin drug targets; 2)...
9844542 Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mGluR5  
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the...
US20170349571 POSITIVE ALLOSTERIC MODULATORS OF HUMAN MELANOCORTIN-4 RECEPTOR  
Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.
US20170348398 COMPOSITIONS AND METHODS FOR DECREASING BLOOD GLUCAGON LEVELS  
Disclosed are improved compositions and methods for decreasing blood glucagon levels. As disclosed herein, L-glutamine is a selective stimulator of α-cell proliferation generated when glucagon...
US20170340614 Compositions and Methods of Treating Muscular Dystrophy with Thromboxane-A2 Receptor Antagonists  
The present invention is directed to methods of treating and/or ameliorating muscular dystrophy and/or treating cardiomyopathy in muscular dystrophy patients by administration of a therapeutically...
9826904 System and method for detecting tissue surface properties  
A system and method for detecting a tissue property. The system comprises a first unit positioned outside a patient body and a second unit positioned inside the patient's body. The first unit...
US20170333520 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS INVOLVING EPITHELIAL CELL APOPTOSIS  
The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g.,...
US20170333222 SYSTEMS AND METHOD FOR VOLITIONAL CONTROL OF JOINTED MECHANICAL DEVICE BASED ON SURFACE ELECTROMYOGRAPHY  
Systems and methods for controlling a weight bearing member having at least one powered joint are provided. A system includes a velocity reference module for receiving myoelectric control signals...
US20170332919 Device and Method for Hemorrhage Detection and Guided Resuscitation and Applications of Same  
Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure...
9824440 Methods and systems for three-dimensional real-time intraoperative surgical margin evaluation of tumor tissues  
In one aspect, the present invention relates to a system evaluating a surgical margin of tumor tissues of a living subject. In one embodiment, the system includes a light source configured to emit...
9821050 Chimeric dengue virus E glycoproteins comprising mutant domain I and domain II hinge regions  
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid...
US20170327906 METHODS FOR PREDICTING AND REDUCING RISK OF COPPER DEFICIENCY IN A RUMINANT SUBJECT OR A RUMINANT HERD  
A method for treating copper deficiency in a ruminant subject or a ruminant herd is dexcribed. In some embodiments, the method involves providing a sample from the subject or at least one subject...
US20170325787 PHANTOM DESIGN FOR TESTING OF DOPPLER ULTRASOUND FUNCTION  
A Doppler phantom includes a first reservoir, a second reservoir, a fluid line coupling the first and second reservoirs, a pressure line coupling the first and second reservoirs, and a tissue...
US20170319611 METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS  
Disclosed are methods of treating viral infections or disorders of uncontrolled proliferation comprising, in one aspect, administering compounds that are phospholipase D inhibitors and/or Akt...
9808501 Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome  
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis,...
US20170313701 Fused Heterocyclic Compounds as Selective BMP Inhibitors  
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be...
US20170312460 Administering the Noble Gas Argon during Cardiopulmonary Resuscitation  
Method of treating an individual following a period of ischemia are provided. The methods include administering inhaled agents postconditioning to the individual and optionally simultaneously...
US20170312255 IFETROBAN TREATMENT FOR SYSTEMIC SCLEROSIS  
The present invention is directed to methods of treating, preventing, and/or ameliorating systemic sclerosis, by administration of a therapeutically effective amount of ifetroban or a...
9803758 Spool and body architectures for three-position directional control valves  
A directional-control valve is typically comprised of a valve spool that slides linearly within a valve body. The valve body typically includes five internal ports, which are covered or exposed as...
9801946 Synthetic polyurethane composite  
Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such...
9795640 Controlling appetite, promoting weight loss, reducing body fat, and/or improving glucose tolerance  
A method for treating obesity, insulin sensitivity, and related conditions involves administering to the subject a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a...
US20170299676 UNIFORM RADIO FREQUENCY MAGNETIC FIELDS IN THE BODY FOR HIGH FIELD MRI  
Methods for operating a magnetic resonance apparatus and systems therefrom are provided. A method includes generating, via a coil former surrounding a subject or object of interest and disposed in...
US20170296849 ADSORBENT MATERIALS AND METHODS OF MAKING AND USE THEREOF  
Disclosed are adsorbent materials that comprise a porous material having a continuous silica phase coated with a carbon layer, and a water-insoluble precipitate comprising a metal cation and an...
9790245 Water soluble catalysts for NMR/MRI enhancement  
Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts....
9783510 Small molecule mediated transcriptional induction of E-cadherin  
In one aspect, the invention relates to N-acetamidoalkyl-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional...
9782152 Method and system for real-time compression correction for tracked ultrasound and applications of same  
A method for real-time correction of tissue compression for tracked ultrasound includes acquiring an ultrasound image of tissues of interest with an ultrasound probe having a probe surface, where...
US20170283387 METABOLISM PROBES FOR THERAPY AND DIAGNOSIS  
Novel 2-substituted glutamylanides useful as modulators of ASCT2 inhibitors. Compounds of the present invention can be used to treat patients suffering from diseases caused or influenced by...
US20170281453 MOVEMENT ASSISTANCE DEVICE  
A apparatus includes an a exoskeleton system with a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton system, a hip...
9775557 Quantifying breast tissue changes with spectrally selective MRI and MRS  
Systems and methods for magnetic resonance analysis and imaging are provided. IN particular, pulse sequences for DWI, APT, and MRS analysis and imaging are provided which rely on an RF excitation...
US20170265950 DEXTEROUS WRISTS  
A rotatable wrist connecting a gripper tool to the distal end of a positioning shaft. The rotatable wrist includes a wrist hub that is non-rotatably connected to the distal end of the shaft. A...
9767573 System and method for correcting data for deformations during image-guided surgical procedures  
Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure are provided. The system and method includes obtaining a...
US20170258771 Compositions and Methods of Treating Cardiac Fibrosis with Ifetroban  
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective...
9757463 Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures  
Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the...
9757038 Optical coherence tomography probe  
A miniature intraoperative probe (30) capable of forward-imaging with optical coherence tomography. The probe includes a housing (130), an actuator (150) supported by the housing, and a single...
US20170253617 Substituted 5-Membered Heterocyclic Analogs as Protease Activated Receptor 4 (PAR-4) Antagonists  
Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating...
9750620 Systems and control methodologies for improving stability in powered lower limb devices  
Systems and methods are provided for controlling a lower limb device having at least one powered joint. The method includes detecting a stumble event based on one or more sensor signals associated...
US20170250431 POLYMER SOLUTION, FIBER MAT, AND NANOFIBER MEMBRANE-ELECTRODE-ASSEMBLY THEREWITH, AND METHOD OF FABRICATING SAME  
In one aspect of the present invention, a fiber mat is provided. The fiber mat includes at least one type of fibers, which includes one or more polymers. The fiber mat may be a single fiber mat...
US20170247366 SUBSTITUTED 4-ALKOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME  
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the...
US20170246149 COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS  
Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting...
US20170245889 MOVEMENT DAMPENING SYSTEM FOR A SURGICAL TOOL  
A movement dampening system for a surgical tool. The system includes a height-adjustable base positionable adjacent to a surgical site on a patient. An elastic damper is disposed adjacent to the...