Patents and Patent Applications from Vanderbilt University


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US20170299676 UNIFORM RADIO FREQUENCY MAGNETIC FIELDS IN THE BODY FOR HIGH FIELD MRI  
Methods for operating a magnetic resonance apparatus and systems therefrom are provided. A method includes generating, via a coil former surrounding a subject or object of interest and disposed in...
US20170296849 ADSORBENT MATERIALS AND METHODS OF MAKING AND USE THEREOF  
Disclosed are adsorbent materials that comprise a porous material having a continuous silica phase coated with a carbon layer, and a water-insoluble precipitate comprising a metal cation and an...
9790245 Water soluble catalysts for NMR/MRI enhancement  
Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts....
9783510 Small molecule mediated transcriptional induction of E-cadherin  
In one aspect, the invention relates to N-acetamidoalkyl-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional...
9782152 Method and system for real-time compression correction for tracked ultrasound and applications of same  
A method for real-time correction of tissue compression for tracked ultrasound includes acquiring an ultrasound image of tissues of interest with an ultrasound probe having a probe surface, where...
US20170283387 METABOLISM PROBES FOR THERAPY AND DIAGNOSIS  
Novel 2-substituted glutamylanides useful as modulators of ASCT2 inhibitors. Compounds of the present invention can be used to treat patients suffering from diseases caused or influenced by...
US20170281453 MOVEMENT ASSISTANCE DEVICE  
A apparatus includes an a exoskeleton system with a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton system, a hip...
9775557 Quantifying breast tissue changes with spectrally selective MRI and MRS  
Systems and methods for magnetic resonance analysis and imaging are provided. IN particular, pulse sequences for DWI, APT, and MRS analysis and imaging are provided which rely on an RF excitation...
US20170265950 DEXTEROUS WRISTS  
A rotatable wrist connecting a gripper tool to the distal end of a positioning shaft. The rotatable wrist includes a wrist hub that is non-rotatably connected to the distal end of the shaft. A...
9767573 System and method for correcting data for deformations during image-guided surgical procedures  
Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure are provided. The system and method includes obtaining a...
US20170258771 Compositions and Methods of Treating Cardiac Fibrosis with Ifetroban  
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective...
9757463 Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures  
Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the...
9757038 Optical coherence tomography probe  
A miniature intraoperative probe (30) capable of forward-imaging with optical coherence tomography. The probe includes a housing (130), an actuator (150) supported by the housing, and a single...
US20170253617 Substituted 5-Membered Heterocyclic Analogs as Protease Activated Receptor 4 (PAR-4) Antagonists  
Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating...
9750620 Systems and control methodologies for improving stability in powered lower limb devices  
Systems and methods are provided for controlling a lower limb device having at least one powered joint. The method includes detecting a stumble event based on one or more sensor signals associated...
US20170250431 POLYMER SOLUTION, FIBER MAT, AND NANOFIBER MEMBRANE-ELECTRODE-ASSEMBLY THEREWITH, AND METHOD OF FABRICATING SAME  
In one aspect of the present invention, a fiber mat is provided. The fiber mat includes at least one type of fibers, which includes one or more polymers. The fiber mat may be a single fiber mat...
US20170247366 SUBSTITUTED 4-ALKOXYPICOLINAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME  
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the...
US20170246149 COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS  
Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting...
US20170245889 MOVEMENT DAMPENING SYSTEM FOR A SURGICAL TOOL  
A movement dampening system for a surgical tool. The system includes a height-adjustable base positionable adjacent to a surgical site on a patient. An elastic damper is disposed adjacent to the...
US20170245741 HYDRO-JET ENDOSCOPIC CAPSULE AND METHODS FOR GASTRIC CANCER SCREENING IN LOW RESOURCE SETTINGS  
Systems and methods are provided for controlling lateral movement of a medical capsule system. A capsule housing is configured to be inserted into an anatomical structure of a patient. The...
9747490 Cell size imaging  
In the various embodiments, cell size imaging is performed using a method that relies upon the acquisition of gradient echo and spin echo data during contrast agent (CA) passage through tissue and...
9745419 Aqueous polyglycidol synthesis with ultra-low branching  
Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is...
9745377 Immunological compositions as cancer therapeutics  
The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto....
9744171 Positive allosteric modulators for melanocortin receptors  
Positive allosteric modulators of melanocortin receptors, especially allosteric potentiators of the receptors MC3R and MC4R are described herein. Also provided are pharmaceutical compositions...
US20170238841 ORAL END TIDAL CARBON DIOXIDE PROBE FOR DIAGNOSING PULMONARY ARTERIAL HYPERTENSION  
This disclosure concerns improved capabilities for evaluating pulmonary arterial hypertension (PAH). A system and method of evaluating PAH in a subject may include measuring end tidal partial...
9738725 Antibodies to TIP-1  
The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
9738636 Fused heterocyclic compounds as selective BMP inhibitors  
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be...
9737364 Local magnetic actuation of surgical devices  
A method of actuating a surgical device is described. A surgical tool is inserted into a body cavity of a patient through a natural orifice. A distal end of an actuation tool is inserted through a...
9732132 Therapeutic compositions and methods for disorders associated with neuronal degeneration  
Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including...
9730815 Control system for a grasping device  
A method for operating a grasping device and grasping devices therefrom are provided. The grasping device is configured to use a plurality of parallel, bi-directional state flow maps each defining...
US20170226583 IDENTIFICATION OF CATTLE AT RISK OF HIGH ALTITUDE PULMONARY HYPERTENSION  
Provided herein are methods and compositions for determining the susceptibility of cattle to High Altitude Pulmonary Hypertension. Also provide are kits and reagents for performing such methods.
9725687 Integrated human organ-on-chip microphysiological systems  
The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
US20170220850 SYSTEM FOR INTERPRETATION OF IMAGE PATTERNS IN TERMS OF ANATOMICAL OR CURATED PATTERNS  
Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it...
US20170219721 GAMMA RAY SPECTROSCOPE FOR DETERMINING A COMPOSITION OF AN ASTEROID OR THE REGOLITH OF THE ASTEROID  
Disclosed and described herein are embodiments and methods of use of a gamma ray spectroscope. In one aspect the gamma ray spectroscope comprises a scintillator for receiving radiation and a...
US20170208809 Compositions for Inhibition of Insect Sensing  
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting)...
US20170205377 APPARATUS AND METHODS FOR PROBING A MATERIAL AS A FUNCTION OF DEPTH USING DEPTH-DEPENDENT SECOND HARMONIC GENERATION  
A method for non-invasively probing at least one physics property of a solid material. In one embodiment, the method has the steps of splitting a photon beam into a first photon beam and a second...
US20170204195 ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF  
Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an...
9708278 Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1  
In one aspect, the invention relates to N-substituted 3,4-dihydro-benzo[£][1,4]oxazine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric...
9707550 Heterogeneous catalysts for NMR/MRI enhancement via signal amplification by reversible exchange (SABRE)  
Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing...
US20170190717 Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase  
Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.
9693998 Compositions and methods of treating cardiac fibrosis with ifetroban  
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective...
9693926 Movement assistance device  
A apparatus includes an a exoskeleton system with a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton system, a hip...
US20170182659 SYSTEMS AND METHODS FOR SAFE COMPLIANT INSERTION AND HYBRID FORCE/MOTION TELEMANIPULATION OF CONTINUUM ROBOTS  
Methods and systems are described for controlling movement and an applied force at the tip of the continuum robot that includes a plurality of independently controlled segments along its length....
9687303 Dexterous wrists for surgical intervention  
A rotatable wrist connecting a gripper tool to the distal end of a continuum robot shaft. The rotatable wrist includes a wrist hub that is non-rotatably connected to the distal end of the shaft. A...
9687190 Intra-operative use of fluorescence spectroscopy and applications of same  
In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of...
9687176 Oral end tidal carbon dioxide probe for diagnosing pulmonary arterial hypertension  
This disclosure concerns improved capabilities for evaluating pulmonary arterial hypertension (PAH). A system and method of evaluating PAH in a subject may include measuring end tidal partial...
US20170177967 METHODS FOR AUTOMATIC SEGMENTATION OF INNER EAR ANATOMY IN POST-IMPLANTATION CT AND APPLICATIONS OF SAME  
A method for automatic segmentation of intra-cochlear anatomy in post-implantation CT image of bilateral cochlear implant recipients includes coarsely segmenting a labyrinth with a labyrinth...
US20170174689 SUBSTITUTED INDOLE MCL-1 INHIBITORS  
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for...
US20170172595 SURGICAL GRASPER  
A surgical grasper includes a first handle arm, a second handle arm pivotally coupled to the first handle arm, a tool body pivotally coupled to both the first handle arm and the second handle arm,...
9682120 Compositions and methods for the treatment of disorders involving epithelial cell apoptosis  
The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g.,...