Patents and Patent Applications from Vanderbilt University


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US20180106386 SPOOL AND BODY ARCHITECTURES FOR THREE-POSITION DIRECTIONAL CONTROL VALVES  
A directional-control valve is typically comprised of a valve spool that slides linearly within a valve body. The valve body typically includes five internal ports, which are covered or exposed as...
US20180104010 BIOMECHANICAL MODEL ASSISTED IMAGE GUIDED SURGERY SYSTEM AND METHOD  
A method for image guided surgery includes obtaining intraoperative locations including intraoperative fiducial locations for a non-rigid structure and intraoperative rigid structure locations for...
9943494 Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage  
Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor...
US20180092359 BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING  
In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host...
US20180086776 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4  
Disclosed herein are substituted 8-aminothieno[3,2-e][1,2,4]triazolo[4,3-b]pyridazine-7-carbo xamide compounds, which may be useful as positive allosteric modulators of the muscarinic...
US20180086767 WDR5 INHIBITORS AND MODULATORS  
Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for...
US20180085475 Composition and Method for Detecting Hypoxia  
A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing...
9926345 Compositions and methods for treating or preventing Clostridium infection  
Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that...
US20180080570 ORGAN ON CHIP INTEGRATION AND APPLICATIONS OF THE SAME  
A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged...
US20180079802 ANTIBODY-MEDIATED NEUTRALIZATION OF CHIKUNGUNYA VIRUS  
The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
US20180078607 ALPHAA-CRYSTALLIN MIMETIC PEPTIDES AND USES THEREOF  
This invention relates to αA-crystallin protein modulating compounds (e.g., phosphomimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the...
9920775 Distributed piston elastomeric accumulator  
The present invention is a distributed piston elastomeric accumulator which stores energy when its elastomeric member stretches from its original length in response to the flow of a pressurized...
US20180072674 NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2  
Described are negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions...
US20180064749 CONJUGATION OF LIPOPHILIC ALBUMIN-BINDING MOIETY TO RNA FOR IMPROVED CARRIER-FREE IN VIVO PHARMACOKINETICS AND GENE SILENCING  
Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a...
US20180057491 ISOQUINOLINE AMIDE AND ISOQUINOLINE AMIDE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180057490 BENZOMORPHOLINE AND BENZOMORPHOLINE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180055913 RECOMBINANT COLLAGEN IV SURROGATES AND USES THEREOF  
The disclosure describes compositions that mimic certain structural and functional characteristics of collagen IV. Additionally provided are methods for the recombinant production of said...
9905870 Nanofiber electrode and method of forming same  
In one aspect, a method of forming an electrode for an electrochemical device is disclosed. In one embodiment, the method includes the steps of mixing at least a first amount of a catalyst and a...
9901412 Dexterous surgical manipulator and method of use  
A surgical manipulator includes an internal working end having an internal joint, and an external control interface linked to the internal working end for controlling the internal working end. The...
US20180053298 METHODS AND SYSTEMS FOR THREE-DIMENSIONAL REAL-TIME INTRAOPERATIVE SURGICAL MARGIN EVALUATION OF TUMOR TISSUES  
A method of evaluating a surgical margin of tumor tissues of a living subject includes acquiring images of a specimen of the tumor tissues; calculating a three-dimensional (3D) morphological...
US20180050083 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER DISORDERS ASSOCIATED WITH METABOLIC SYNDROME  
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis,...
9895351 Indomethacin analogs for the treatment of castrate-resistant prostate cancer  
Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin...
9889504 Porous nanomaterials having three-dimensional patterning  
Provided are methods for imprinting a porous material, the methods including applying a first stamp to a porous material having an average pore size of less than about 100 μm, the first stamp...
US20180036311 TREATMENT FOR HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES (HNPP)  
A method of treating demyelinating diseases involves administering a PAK1 inhibitor that is PF-3758309 to a subject in need of such treatment.
9883850 Assessment of right ventricular function using contrast echocardiography  
Systems and methods are provided for determining a right ventricular transit time for a patient. An echodense contrast is injected into a patient. A first representative region, representing the...
US20180030105 Therapeutic Compositions and Methods for Disorders Associated with Neuronal Degeneration  
Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including...
US20180028501 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4  
Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and imidazo[1,2-a]thieno[3,2-e]pyridin-3-amine compounds, which may be...
US20180028440 Milrinone Composition and Method for Administering Same  
Embodiments of the present invention include inhalable composition, comprising milrinone or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier, an excipient, a...
US20180022746 INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180022745 ISOQUINILINE AND NAPTHALENE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the...
US20180022744 BENZOTHIAZOLE AND BENZISOTHIAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180022712 NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3  
Described are negative allosteric modulators of metabotropic glutamate receptor 3 (mGlu3), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions...
US20180021312 BENZOISOXAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180020935 INTRAVENOUS ACCESS DEVICE DETECTING INTRAVENOUS INFILTRATION AND IN-VEIN PLACEMENT  
Aspects of the invention relates to systems and methods for monitoring an intravenous (IV) line functionality of an IV device. In one embodiment, the system includes an IV catheter to be inserted...
9876246 Nanofiber membrane-electrode-assembly and method of fabricating same  
In one aspect of the present invention, a method of fabricating a fuel cell membrane-electrode-assembly (MEA) having an anode electrode, a cathode electrode, and a membrane disposed between the...
9874285 Organ on chip integration and applications of the same  
A platform for cultivation, maintenance, and/or analysis of one or more bio-objects includes one or more integrated bio-object microfluidics modules. Each integrated bio-object microfluidics...
9870678 Dynamic alarm system for reducing alarm fatigue  
A dynamic alarm system that can assess the background noise in a clinical environment with sub-minute time sampling and change the alarm output to a desired signal-to-noise ratio (SNR) below...
9869675 Low resource processor using surface tension valves for extracting, concentrating, and detecting whole cells  
Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and...
9868746 Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4  
In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric...
9868647 System and methods for removing impurities from phosphogypsum and manufacturing gypsum binders and products  
Methods and systems that remove impurities from phosphogypsum (PG), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, PG is reacted with a...
9867879 Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO)  
A method for treating a microbial infection involves administering an effective amount of a compound of the formula: wherein R1 is H, alkyl, aryl, heteroaryl, R2 is H, halogen, alkyl, aryl,...
US20180005391 SYSTEM AND METHOD FOR CORRECTING DATA FOR DEFORMATIONS DURING IMAGE-GUIDED PROCEDURES  
Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure are provided. The system and method includes obtaining a...
US20180005381 IMAGE SEGMENTATION VIA MULTI-ATLAS FUSION WITH CONTEXT LEARNING  
Systems and methods are provided for segmenting tissue within a computed tomography (CT) scan of a region of interest into one of a plurality of tissue classes. A plurality of atlases are...
9856348 Multifunctional degradable nanoparticles with control over size and functionalities  
In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one...
US20170373434 MULTI-PLATFORM MODULAR DEVICE  
A multi-platform modular device including a plurality of platforms or modules. Each module implements a different function and can be connected to another module via a plurality of magnetic...
US20170369505 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4  
Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine,...
US20170364630 IDENTIFICATION OF CELLULAR ANTIMICROBIAL DRUG TABLETS THROUGH INTERACTOME ANALYSIS  
A method of identifying a promising cellular antiviral or bacterial toxin drug target is described including: 1) providing a plurality of potential antiviral or bacterial toxin drug targets; 2)...
9844542 Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mGluR5  
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the...
US20170349571 POSITIVE ALLOSTERIC MODULATORS OF HUMAN MELANOCORTIN-4 RECEPTOR  
Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.
US20170348398 COMPOSITIONS AND METHODS FOR DECREASING BLOOD GLUCAGON LEVELS  
Disclosed are improved compositions and methods for decreasing blood glucagon levels. As disclosed herein, L-glutamine is a selective stimulator of α-cell proliferation generated when glucagon...