Patents and Patent Applications from Vanderbilt University


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US20180202998 Method for Identifying Subjects with Increased Risk of ST-Segment Elevation Myocardial Infarction (STEMI) and Identifying Subjects Likely to Respond to Particular Treatments  
A method for identifying an increased risk of developing ST-Segment Elevation Myocardial Infarction (STEMI) in a subject involves obtaining a platelet-containing plasma sample from the subject;...
10023832 Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same  
The invention relates to a system of fluidic valves and pumps and associated fluidic channels integratable into a bio-object microfluidics module. The module includes input and output buses;...
US20180193001 PHANTOM DESIGN FOR TESTING OF DOPPLER ULTRASOUND FUNCTION  
A Doppler phantom includes a first reservoir, a second reservoir, a fluid line coupling the first and second reservoirs, a pressure line coupling the first and second reservoirs, and a tissue...
US20180192651 THERMAL VOLATILIZATION OF ORCO AGONISTS  
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting)...
10016399 Compositions and methods of treating cardiac fibrosis with ifetroban  
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective...
10016290 Walking controller for powered ankle prostheses  
Described herein are systems and methods for a powered ankle/foot prosthesis and controller that utilizes piecewise emulated passive impedances to provide for walking at various cadences and on...
US20180180614 ANTIBODY-MEDIATED NEUTRALIZATION OF EBOLA VIRUSES  
The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus...
US20180179205 SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1  
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric...
10005728 Substituted indole Mcl-1 inhibitors  
The present application, among other things, provides compounds that are capable of inhibiting the activity of anti-apoptotic Bcl-2 family proteins, for example, myeloid cell leukemia-1 (Mcl-1)...
US20180174976 TRANSIENT ELECTRONICS USING THERMORESPONSIVE MATERIALS  
A composite element and methods of fabrication thereof are provided. The composite element can include a binder material and one or more electrical traces supported by the binder material, where a...
US20180171408 Characterizing Gastro-Intestinal Disease  
A method for characterizing a gastro-intestinal disease in a subject involves comparing ratios of expression levels of genes in a biological sample from a subject to references, wherein the...
US20180171393 MONITORING AND ANALYSIS OF NUCLEIC ACID HYBRIDIZATION STATE AND AMPLIFICATION USING L-DNA  
Systems, methods, and compositions for monitoring and analyzing nucleic acid hybridization state using L-DNA probes are described. The methods include adding L-DNA probes that can be fluorescently...
US20180170766 SYSTEM AND METHODS FOR REMOVING IMPURITIES FROM PHOSPHOGYPSUM AND MANUFACTURING GYPSUM BINDERS AND PRODUCTS  
Methods and systems that remove impurities from phosphogypsum (PG), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, PG is reacted with a...
9995808 MRI using RF gradients for spatial encoding  
Systems and methods for performing MRI include using a RF gradient field for spatial encoding. In particular implementations, |B+i|-selective pulses designed using the Shinnar-Le Roux algorithm...
9986914 Method of fabricating a probe  
An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with...
9980945 Benzoisoxazole-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180142061 Multifunctional Degradable Nanoparticles with Control over Size and Functionalities  
In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one...
US20180140369 DEXTEROUS SURGICAL MANIPULATOR AND METHOD OF USE  
A surgical manipulator includes an internal working end having an internal joint, and an external control interface linked to the internal working end for controlling the internal working end. The...
US20180138519 NANOFIBER ELECTRODE AND METHOD OF FORMING SAME  
A method of forming an electrode for an electrochemical device includes mixing at least a first amount of a catalyst and a second amount of an ionomer or an uncharged polymer to form a liquid...
US20180134843 AQUEOUS POLYGLYCIDOL SYNTHESIS WITH ULTRA-LOW BRANCHING  
Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is...
US20180126046 Development and Vascular Applications of Shape Memory External Stents  
The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some...
US20180125983 Linear Polyester and Semi-Linear Glycidol Polymer Systems: Formulation and Synthesis of Novel Monomers and Macromolecular Structures  
Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the...
US20180125964 CHIMERIC DENGUE VIRUS E GLYCOPROTEINS COMPRISING MUTANT DOMAIN I AND DOMAIN II HINGE REGIONS  
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid...
9964741 Telecentric lens assembly providing a collimated light space  
Systems and methods for imaging a target are provided. A system includes a detector and a substantially bitelecentric lens assembly positioned between the detector and the target. A first optical...
9964125 Directional control valve with double-solenoid configurations  
A double-solenoid directional control valve comprising a valve body and a valve spool within the valve body, where the valve spool is configured to move within the valve body between a first...
9963466 Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (PAR-4) antagonists  
Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating...
9962426 Reelin rescues cognitive function  
Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is...
US20180120302 FREE SOLUTION MEASUREMENT OF MOLECULAR INTERACTIONS BY BACKSCATTERING INTERFEROMETRY  
Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry. In one aspect, the invention relates to method and...
US20180118746 SUBSTITUTED IMIDAZOPYRIDINE AND TRIAZOLOPYRIDINE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR M1  
In one aspect, the invention relates to substituted imidazopyridine and triazolopyridine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of...
9956042 Systems and methods for robot-assisted transurethral exploration and intervention  
Systems and methods are described for using a robotic system to perform procedures within a cavity using a virtual fixture. The robotic system includes a rigid central stem including an access...
9950096 Particle/polyurethane composites and methods thereof  
The present invention encompasses the finding that certain treatments (e.g., surface modifications) to particulate materials can provide surprising and unexpected benefits and/or features to...
9949965 Tricyclic indole Mcl-1 inhibitors and uses thereof  
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for...
US20180106386 SPOOL AND BODY ARCHITECTURES FOR THREE-POSITION DIRECTIONAL CONTROL VALVES  
A directional-control valve is typically comprised of a valve spool that slides linearly within a valve body. The valve body typically includes five internal ports, which are covered or exposed as...
US20180104010 BIOMECHANICAL MODEL ASSISTED IMAGE GUIDED SURGERY SYSTEM AND METHOD  
A method for image guided surgery includes obtaining intraoperative locations including intraoperative fiducial locations for a non-rigid structure and intraoperative rigid structure locations for...
9943494 Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage  
Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor...
US20180092359 BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING  
In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host...
US20180086776 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4  
Disclosed herein are substituted 8-aminothieno[3,2-e][1,2,4]triazolo[4,3-b]pyridazine-7-carbo xamide compounds, which may be useful as positive allosteric modulators of the muscarinic...
US20180086767 WDR5 INHIBITORS AND MODULATORS  
Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for...
US20180085475 Composition and Method for Detecting Hypoxia  
A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing...
9926345 Compositions and methods for treating or preventing Clostridium infection  
Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that...
US20180080570 ORGAN ON CHIP INTEGRATION AND APPLICATIONS OF THE SAME  
A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged...
US20180079802 ANTIBODY-MEDIATED NEUTRALIZATION OF CHIKUNGUNYA VIRUS  
The present disclosure is directed to antibodies binding to and neutralizing Chikungunya virus (CHIKV) and methods for use thereof.
US20180078607 ALPHAA-CRYSTALLIN MIMETIC PEPTIDES AND USES THEREOF  
This invention relates to αA-crystallin protein modulating compounds (e.g., phosphomimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the...
9920775 Distributed piston elastomeric accumulator  
The present invention is a distributed piston elastomeric accumulator which stores energy when its elastomeric member stretches from its original length in response to the flow of a pressurized...
US20180072674 NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2  
Described are negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions...
US20180064749 CONJUGATION OF LIPOPHILIC ALBUMIN-BINDING MOIETY TO RNA FOR IMPROVED CARRIER-FREE IN VIVO PHARMACOKINETICS AND GENE SILENCING  
Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a...
US20180057491 ISOQUINOLINE AMIDE AND ISOQUINOLINE AMIDE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180057490 BENZOMORPHOLINE AND BENZOMORPHOLINE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20180055913 RECOMBINANT COLLAGEN IV SURROGATES AND USES THEREOF  
The disclosure describes compositions that mimic certain structural and functional characteristics of collagen IV. Additionally provided are methods for the recombinant production of said...
9905870 Nanofiber electrode and method of forming same  
In one aspect, a method of forming an electrode for an electrochemical device is disclosed. In one embodiment, the method includes the steps of mixing at least a first amount of a catalyst and a...