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US20120120226 |
TRANSMISSION ELECTRON MICROSCOPY FOR IMAGING LIVE CELLS
In one aspect, the present invention relates to a microfluidic chamber. In one embodiment, the microfluidic chamber has a first sub-chamber and at least one second sub-chamber. The first...
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8168804 |
Large stoke shift NIR dyes
A compound of the following formula: wherein R1 is SO3H; R2 is chosen from carboxylic acid group and SO3H; and R3 is chosen from Cl, carboxylic acid group, amino, amino-carboxylic acid group, amido...
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8168656 |
Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet...
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8168084 |
Polar nematic compounds
Polar nematic compounds, one example of which has the following structure: is a caged boron structure, where the sphere of the caged boron structure is C and each non-sphere vertex of the caged...
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8158344 |
Methods and compositions for correlating genetic markers with multiple sclerosis
The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence...
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US20120089017 |
LIGANDS TO RADIATION-INDUCED MOLECULES
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to...
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US20120088835 |
METHODS AND COMPOSITIONS FOR TREATMENT FOR CORONARY AND ARTERIAL ANEURYSMAL SUBARACHNOID HEMORRHAGE
Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to...
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US20120088791 |
AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME
In one aspect, the invention relates to compounds having a general structure: Formula (I) which are useful as allosteric agonists of the M1 muscarinic receptor, synthetic methods for making the...
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US20120085449 |
High Energy Density Elastic Accumulator and Method of Use Thereof
The invention is an accumulator which stores energy by deforming from its original shape in response to the flow of a pressurized fluid. The stored energy is returned when the fluid flow is...
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8153368 |
Four-jointed box (FJX1) in cancer diagnosis and treatment
The present invention relates to a new tumor suppressor, designated FJX1. Also described are diagnostic, prognostic and therapeutic uses of the FJX1 protein and the FJX1 gene, alone or in...
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8152809 |
Flat cut bit for cranial perforator
Described herein is a cranial surgery drill bit having a safety self stopping mechanism for use on bone material to prevent or repair skin erosion and infection which may result from the placement...
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8148170 |
Immunosensors: scFv-linker design for surface immobilization
An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged...
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8143302 |
Methods and compositions for diagnostic and therapeutic targeting of COX-2
The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the...
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8134707 |
On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes
A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26)...
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US20120058109 |
REELIN RESCUES COGNITIVE FUNCTION
Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is...
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8129356 |
Bmx mediated signal transduction in irradiated vascular endothelium
Provided are methods for modulating the proliferation of cells and tissues. In some embodiments, the methods include administering to a subject an effective amount of a modulator of a biological...
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8129179 |
Bioreactors with an array of chambers and a common feed line
A bioreactor (200) for cultivating living cells in a liquid medium. In one embodiment, the bioreactor (200) has a substrate (230) having a first surface and an opposite second surface, defining a...
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8120777 |
Temperature-stable interferometer
This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of ...
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US20120041685 |
SYSTEM AND METHOD FOR ESTIMATING RADIATION DOSE AND DISTRIBUTION USING MEDIUM-DEPENDENT-CORRECTION BASED ALGORITHMS (MDC)
Systems and methods for accurately calculating radiation doses in biological tissues exposed to a radiation source are provided. In the systems and methods first, a radiation dose is computed to...
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8116549 |
Method and apparatus for standardizing ultrasonography training using image to physical space registration of tomographic volumes from tracked ultrasound
A clinical and training apparatus that collects and processes physical space data while performing an image-guided procedure on an anatomical area of interest includes a calibration probe, a...
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8109630 |
Illuminated low-vision spectacles
Lighted reading glasses for individuals with low vision. In one embodiment, the reading glasses include a frame for supporting lenses having an oculus dexter side and an oculus sinister side, at...
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US20120029340 |
SYSTEM AND METHOD FOR DETERMINING MECHANICAL PROPERTIES OF BONE STRUCTURES
Systems and methods for characterizing bone structures are provided for characterizing bone structures. In the system and method, one or more 1H NMR or MRI signals associated with a bone structure...
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US20120022683 |
LATERAL POSITION DETECTION AND CONTROL FOR FRICTION STIR SYSTEMS
An apparatus and computer program are disclosed for processing at least one workpiece using a rotary tool with rotating member for contacting and processing the workpiece. The methods include...
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US20120021979 |
GLP-1 receptor modulation of addiction, neuropsychiatric disorders and erectile dysfunction
The present invention involves the use of GLP-1 and its analogs or GLP-1 receptor agonists to modulate dopamine transporter signaling. The implications of this ability include the use of MT-1 and...
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US20120021189 |
Pre-coated surfaces for analysis
Sample preparation can be a tedious and time consuming task. For example, MALDI imaging of tissue samples can require the tedious process of hand or robotically spotting solutions containing...
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8101157 |
Ligands to radiation-induced molecules
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to...
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US20120016256 |
APPARATUS AND METHOD FOR DETECTING AND MEASURING CONDITION OF ESOPHAGEAL MUCOSA AND INDICATIONS OF GASTROESOPHAGEAL REFLUX DISEASE
A mucosal impedance measuring system that is capable of direct and accurate impedance measurements of esophageal mucosa includes example multi-channel intraluminal impedance catheters with...
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US20120015428 |
METERING ROTARY NANOPUMP, METHOD OF FABRICATING SAME, AND APPLICATIONS OF SAME
In one aspect of the present invention, a pump includes a cam having a cam shaft, wherein the cam shaft has an axis, an exterior surface and M fins spaced-apart formed on the exterior surface along...
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US20120015376 |
Free Solution Measurement Of Molecular Interactions By Backscattering Interferometry
Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry (BSI). Molecular interaction can be detected between...
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US20120010601 |
ORTHOPEDIC CEMENT AND USE OF SAME IN RADIATION THERAPY
A method of treating diseased tissue in a patient, the diseased tissue being proximate a hardened previously implanted bone cement including relatively high atomic number elements in a patient. The...
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US20120010483 |
INTRA-OPERATIVE USE OF FLUORESCENCE SPECTROSCOPY AND APPLICATIONS OF SAME
In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating...
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US20120004736 |
SYSTEMS AND METHOD FOR VOLITIONAL CONTROL OF JOINTED MECHANICAL DEVICES BASED ON SURFACE ELECTROMYOGRAPHY
Systems and methods for controlling a weight bearing member having at least one powered joint are provided. A system includes a velocity reference module for receiving myoelectric control signals...
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US20120003729 |
CAPILLARY PERFUSED BIOREACTORS WITH MULTIPLE CHAMBERS
A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second...
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8088587 |
Genetic variants increase the risk of age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as...
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8088352 |
Graphitic-carbon-nanofiber/polymer brushes as gas sensors
A composition of matter including at least one graphitic-carbon-nanofiber/polymer brush. A method of making the graphitic-carbon-nanofiber/polymer brush includes covalently bonding a polymer to a...
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US20110319913 |
APPARATUS AND METHODS FOR PERCUTANEOUS COCHLEAR IMPLANTATION
A method and apparatus of percutaneous cochlear implantation (PCI). In one embodiment, the method includes the steps of (a) implanting a plurality of anchor members in a skull of a patient...
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8073216 |
System and methods for automatic segmentation of one or more critical structures of the ear
A system and method for automatic segmentation of a structure of interest of an ear are disclosed, where the structure of interest includes the facial nerve and chorda tympani. In one embodiment,...
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US20110295353 |
PATENT BODY LUMEN STENT
A stent implantable in a patent body lumen. The stent comprises a contiguous wire body having a plurality of sequential reversal coils that, when deployed in the patent lumen, are each configured...
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US20110295271 |
APPARATUS FOR SUPPORTING AN ADJUSTABLE SURGICAL PLATFORM
In one aspect, an apparatus for supporting an adjustable surgical platform is disclosed. In one embodiment, the apparatus includes a supporting platform portion with a body portion that defines...
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US20110295125 |
Apparatus and method for radio frequency ablation of a liver tumor in liver tissues
A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a...
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US20110294202 |
BIOREACTORS WITH MULTIPLE CHAMBERS
A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface,...
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8066644 |
System, method and device for positioning a target located within soft tissue in a path of an instrument
A system, method and device for positioning a target located within soft tissue in a path of an instrument inserted into the soft tissue includes: a manipulation system including a plurality of...
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8065014 |
Method for promoting selective reinnervation of denervated tissue
A method for promoting reinnervation via stimulation of a denervated target tissue, whereby reinnervation of the target tissue by native neurons is enhanced, and whereby reinnervation of the target...
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8060272 |
System and method for image mapping and visual attention
A method is described for mapping dense sensory data to a Sensory Ego Sphere (SES). Methods are also described for finding and ranking areas of interest in the images that form a complete visual...
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8052034 |
Lateral position detection and control for friction stir systems
Friction stir methods are disclosed for processing at least one workpiece using a rotary tool with rotating member for contacting and processing the workpiece. The methods include oscillating the...
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US20110270148 |
PERCUTANEOUS COLLATERAL BYPASS
A bypass provided by a bypass conduit disposed in a vessel which is collateral to an occluded vessel. The bypass conduit comprises a helical wire body having a plurality of connectors connecting...
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8050766 |
Respiratory triggered, bilateral laryngeal stimulator to restore normal ventilation in vocal fold paralysis
A laryngeal stimulation system including a sensor for detecting an occurrence of a respiratory signal in a subject and a laryngeal stimulator adapted for coupling to a laryngeal muscle and operable...
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8048940 |
Reactive graphitic carbon nanofiber reinforced polymeric composites showing enhanced flexural strength
Composites comprising at least one graphite-carbon nanofiber (GCNF) and a polymer phase covalently linked to a surface thereof.
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8034806 |
Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
In one aspect, the invention relates to bicyclic MGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds,...
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US20110246403 |
Method and System for Automated Supervised Data Analysis
The invention relates to a method for automatically analyzing data and constructing data classification models based on the data. In an embodiment of the method, the method includes selecting a...
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