Patents and Patent Applications from University of Washington


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US20180171056 DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS  
Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at...
US20180169365 Intubating Neonatal Laryngeal Mask Airway  
An intubating neonatal laryngeal mask airway includes an elongated body having a palate side and a lingual side. A cuff is coupled to an elongated body opposite a distal end of the elongated body....
10000797 Methods and systems for performing digital measurements  
Methods, devices and systems for performing digital measurements are provided.
10000745 Therapeutic nuclease compositions and methods  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
10000741 Compositions and methods for enhanced gene expression in cone cells  
The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
US20180164329 PROSTATE CANCER-ASSOCIATED SECRETED PROTEINS  
Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate...
US20180161188 ENERGY STORAGE DEVICE FOR AN EXOSKELETON  
Disclosed herein is a leg exoskeleton configured to aid motion (e.g., walking) of a user in need thereof. In particular, the exoskeleton includes a belt configured to attach the exoskeleton to the...
9997778 Polycrystalline vanadium oxide nanosheets  
Improved V2O5 materials are disclosed herein in the form of 2D leaf-like nanosheets. Methods of forming the V2O5 nanosheets and batteries (e.g., lithium-ion) incorporating the V2O5 nanosheets are...
9997344 Methods and devices for generating double emulsions  
The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes...
9994812 Systems and method for engineering muscle tissue  
The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally...
9988679 MSP nanopores and related methods  
Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins,...
US20180148488 NOVEL MICRO-DYSTROPHINS AND RELATED METHODS OF USE  
Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette. Methods of treating a subject having, or at risk...
US20180142293 METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING  
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of...
US20180142226 COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE  
Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO: 1, are provided, wherein (a) the polypeptide...
9979240 Multiband harvesting systems and methods including switching networks  
Examples described herein include systems and methods for multiband harvesting. An example system may include a single wideband antenna followed by several narrowband rectifier chains. Each...
9974767 Statins in the treatment of muscular dystrophies and myopathies  
The invention provides methods and compositions for treating neuromuscular diseases including, but not limited to muscular dystrophies. It is demonstrated herein that statin drugs are therapeutic...
US20180137234 Computational Design of Self-Assembling Cyclic Protein Homo-oligomers  
Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.
US20180133520 METHODS FOR CHARACTERIZING NONLINEAR FIELDS OF A HIGH-INTENSITY FOCUSED ULTRASOUND SOURCE AND ASSOCIATED SYSTEMS AND DEVICES  
The present technology is directed to methods for characterizing nonlinear ultrasound fields and associated systems and devices. In several embodiments, for example, a method of calculating output...
9973367 Apparatuses, systems, and methods for communicating using MIMO and spread spectrum coding in backscatter of ambient signals  
Apparatuses, systems, ambient RF backscatter transceivers, and methods for communicating using MIMO and spread spectrum coding of backscattered ambient RF signals are described. An example system...
9972962 Tuning multi-input complex dynamic systems using sparse representations of performance and extremum-seeking control  
Systems and methods for tuning multi-input complex dynamic systems in order to automatically obtain optimal performance are provided. Training is performed by measuring performance of the complex...
9971414 Devices, systems, and methods for detecting gestures using wireless communication signals  
Examples of systems, devices, and methods are described herein that can provide for gesture recognition. Wireless communication signals are received from sources in an environment (e.g. cellular...
US20180125847 METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSION MODULATION  
Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by...
9964680 Photoluminescent semiconductor nanocrystal-based luminescent solar concentrators  
The present disclosure describes luminescent solar concentrators that include photoluminescent nanoparticles. The photoluminescent nanoparticles include a semiconductor nanocrystal that sensitizes...
9963439 Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase  
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions...
9962230 Instrument organization systems and associated methods  
Organization systems for surgical instruments and associated methods and systems are disclosed herein. In one embodiment, a surgical instrument organization system can be configured for use in a...
US20180119202 Proximity-enhanced nucleic acid-amplified protein detection  
The present technology is related to methods and compositions for detecting, and optionally quantifying, one or more analytes of a sample using nucleic acids. In some embodiments, the methods...
US20180117536 CERAMIC PROTON-CONDUCTING MEMBRANES  
Disclosed herein are ceramic selective membranes and methods of forming the ceramic selective membranes by forming a selective silica ceramic on a porous membrane substrate. Representative ceramic...
US20180117535 CERAMIC PROTON-CONDUCTING MEMBRANES  
Disclosed herein are ceramic selective membranes and methods of forming the ceramic selective membranes by forming a selective silica ceramic on a porous membrane substrate. Representative ceramic...
US20180117125 VECTORS AND METHODS FOR REGENERATIVE THERAPY  
An expression vector capable of disrupting the silencing of cell cycle genes in adult cells, such as adult cardiac myocytes and other quiescent cells in terminally differentiated tissues,...
US20180116744 FERROMAGNETIC SHAPED MEMORY ALLOY NANO-ACTUATOR AND METHOD OF USE  
Nano-actuators having a helical member formed with a ferromagnetic shape memory alloy (FSMA) are disclosed that are elastically deformable between a compressed state and an expanded state by the...
9957501 Nuclease-mediated regulation of gene expression  
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
9956214 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum  
The present disclosure is generally directed to compositions and methods for treating apicomplexan protozoan related disease, such as toxoplasmosis and cryptosporidiosis.
US20180112268 METHODS AND REAGENTS FOR PREDICTING PREDISPOSITION TO REFRACTIVE ERROR  
Methods and reagents for determining a subject's predisposition for refractive error based on the presence of opsin gene exon 3 splicing defects are provided. In one aspect, the invention provides...
9955133 Myopia-safe video displays  
In a first aspect, the present invention provides methods for creating video signals including (a) receiving an input video signal including an input red component, an input green component, and...
9949849 Medial-lateral stabilizing prosthetic ankle/foot for angled and rough ground gait  
A device is provided including a first linkage system and a second linkage system. Each linkage system may include an upper support, a lower support, and a cross bar linkage including a first...
US20180104325 Methods and Compositions for Activation of Innate Immune Responses Through RIG-I Like Receptor Signaling  
Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid...
US20180103834 ADAPTIVE CONTROL OF A FIBER SCANNER WITH PIEZOELECTRIC SENSING  
Improved systems, methods, and devices relating to optical fiber scanners are provided. In one aspect, a scanning apparatus includes an optical fiber and a piezoelectric actuator coupled to the...
9945853 Extracellular mitochondrial components for detecting inflammatory reactions and conditions  
The present disclosure highlights the relationship between extracellular mitochondrial components, optionally in combination with the secreted phospholipase A2-IIA and/or an auto-antibody, and in...
US20180100183 ISOTACHOPHORESIS ENHANCED ISOTHERMAL NUCLEIC ACID AMPLIFICATION  
The present disclosure relates generally to the integration of isotachophoresis (ITP) and isothermal nucleic acid amplification methods such as recombinase polymerase amplification (RPA). One...
US20180098955 METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION  
A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a...
9939299 Sensing events affecting liquid flow in a liquid distribution system  
By monitoring pressure transients in a liquid within a liquid distribution system using only a single sensor, events such as the opening and closing of valves at specific fixtures are readily...
9937475 Dynamic seal to enable movement of a film or fiber through a pressurized space while maintaining a desired pressure  
The present disclosure describes devices capable of continually and controllably passing a polymer film or fiber through a pressurized vessel, while maintaining a desired pressure inside the...
US20180097396 SYSTEMS AND METHODS FOR DIRECT ESTIMATION OF BATTERY PARAMETERS USING ONLY CHARGE/DISCHARGE CURVES  
Electrochemical models for the lithium-ion battery are useful in predicting and controlling its performance. The values of the parameters in these models are vital to their accuracy. However, not...
9933680 Heat-resistant electrolyte materials and electrochromic devices including them  
The present disclosure relates to relates to heat-resistant gel electrolyte materials and their uses, for example, in electrochromic devices such as electrochromic windows. In certain embodiments,...
US20180090777 CERAMIC PROTON-CONDUCTING MEMBRANES  
Disclosed herein are ceramic selective membranes and methods of forming the ceramic selective membranes by forming a selective silica ceramic on a porous membrane substrate. Representative ceramic...
US20180088308 INVERTED LIGHT-SHEET MICROSCOPE  
Devices and techniques for a light sheet microscope device are generally described. In some examples, the light sheet microscope may comprise a motorized movable stage comprising an optically...
US20180086713 CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)  
The present invention provides therapeutic strategies for treatment of severe debilitating diseases associated with IFN-I due to cGAS activation. In one aspect, the invention provides compounds of...
9925249 Compositions and methods for treating celiac sprue disease  
The invention provides compositions and methods for treating celiac sprue.
US20180080863 OPTICAL PAINTING AND FLUORESCENCE-ACTIVATED SORTING OF ADHERENT CELLS  
The present disclosure provides a method of optically marking and sorting adherent cells. In some aspects, the method comprises: providing a plurality of adherent cells attached to a substrate,...
9919088 Implantable heart pump controller  
The present invention provides devices, systems, and methods for control of ventricular assist devices. The invention includes an implantable controller that is operatively programmed to direct...