Patents and Patent Applications from University of Washington


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US20120128227 DEVICE FOR GENERATING ALTERNATIVE OF NORMAL BRAIN DATABASE  
CPU 12 reads out the bloodstream associated values of target voxel of subject's standardized brain bloodstream images (step S34). CPU 12 sorts the bloodstream associated values in descending order...
US20120125156 METHODS FOR PRODUCTION OF SILVER NANOSTRUCTURES  
Methods for producing silver nanostructures with improved dimensional control, yield, purity, monodispersity, and scale of synthesis.
8182809 Methods for treating cancer by inhibiting MIC shedding  
Described herein are compositions and methods for treating cancer, comprising administering to an individual having cancer an agent to prevent MIC shedding (initiated at the alpha-3 ectodomain of...
US20120118052 METHOD AND SYSTEM FOR BACKGROUND SUPPRESSION IN MAGNETO-MOTIVE PHOTOACOUSTIC IMAGING OF MAGNETIC CONTRAST AGENTS  
Method and system for background suppression in magneto-motive photoacoustic imaging of labeled target objects.
8178091 Compositions and methods for the treatment of respiratory disorders  
Methods and compositions are provided for the treatment of acute lung injury and pulmonary fibrosis by administering inhibitors of IGF-1R signaling activity.
US20120112170 CROSS-CONJUGATED POLYMERS FOR ORGANIC ELECTRONIC DEVICES AND RELATED METHODS  
Cross-conjugated donor-acceptor polymers, methods for their preparation, devices that include polymers, and methods for the preparation and use of the devices.
8174700 Portable and cartridge-based surface plasmon resonance sensing systems  
This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can...
8173413 Separation and concentration of biological cells and biological particles using a one-dimensional channel  
This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel...
8173045 Diels-Alder crosslinkable dendritic nonlinear optic chromophores and polymer composites  
Diels-Alder crosslinkable dendritic nonlinear optical chromophore compounds, films and crosslinked polymer composites formed from the chromophore compounds, methods for making and using the...
8168114 Methods for blow molding solid-state cellular thermoplastic articles  
A process for producing cellular thermoplastic articles. The process comprises the steps of treating a solid parison made from a thermoplastic material with a saturating gas at an elevated pressure...
US20120100594 ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS  
The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other...
US20120097551 COPPER-BASED WATER OXIDATION CATALYSTS  
Methods for electrolysis of water to oxygen gas are provided. The method utilizes dimeric copper cations in water at a basic pH. The cations are provided in the water by adding a complex in solid...
8165189 Dirty paper precoding with known interference structure at receiver  
A dirty paper precoding (“DPC”) method for broadcasting a signal is disclosed that takes advantage of knowledge of the structure of interference in order to avoid the quantization noise that res...
8163865 Biocompatible amino acid anhydride polymers  
Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use.
US20120094285 Ratiometric Pre-rRNA Analysis  
Disclosed are compositions and methods for detecting the presence of viable cells in a sample. Included are compositions and methods for increasing the sensitivity of a nucleic acid amplification...
US20120093790 HLA HOMOZYGOUS CELLS AND METHODS OF USE THEREOF  
The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods...
8158556 Activated carbon cryogels and related methods  
Carbon cryogels, methods for making the carbon cryogels, methods for storing a gas using the carbon cryogels, and devices for storing and delivering a gas using the carbon cryogels.
US20120087857 GADOLINIUM EXPRESSED LIPID NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING  
Lipid nanoparticles expressing metal ions and methods for using the compositions for magnetic resonance imaging.
8154787 Electrochromic materials  
Green electrochromic (EC) materials based on thiophene, and a green EC material based on pyrazine are disclosed. A first thiophene derivative (2,3-Di-thiophen-2-yl-thieno[3,4-b]pyrazine), which was...
8153843 Antibacterial agents  
Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds;...
8153366 Methods and compositions for predicting drug responses  
The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized...
8147858 Alginate-based nanofibers and related scaffolds  
Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning.
US20120079630 SUB-MICROSECOND-RESOLUTION PROBE MICROSCOPY  
Methods and apparatus are provided herein for time-resolved analysis of the effect of a perturbation (e.g., a light or voltage pulse) on a sample. By operating in the time domain, the provided...
US20120079628 COMPOSITIONS AND METHODS FOR MODULATION OF PLANT CELL DIVISION  
The present invention provides compositions and methods for modulating cell division in plants. In particular, the present invention provides polynucleotides that encode REVOLUTA. In addition,...
8142369 Measurement and use of in-socket residual limb volume change data for prosthetic fitting  
Changes in the volume of residual limbs on which prosthetic sockets are worn can be measured based on bioimpedance measurements along one or more segments of the limb. A current at an appropriate...
8142168 Vibration-driven droplet transport devices having textured surfaces  
Methods and devices for moving a droplet on an elongated track on a textured surface using vibration. The elongated track on the textured surface includes a plurality of transverse arcuate...
US20120070890 TARGETED GENE MODIFICATION BY PARVOVIRAL VECTORS  
This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the...
US20120067390 METHOD AND SYSTEM FOR GENERATING ELECTRICAL ENERGY FROM WATER  
Method and system for generating electrical energy from a volume of water.
8140043 Simplified high frequency tuner and tuning method  
A disdosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator...
8137615 Automated workstation for disinfecting objects and methods of use thereof  
An automated workstation or apparatus for disinfecting an object in a controlled environment is provided. A method for disinfecting an object in a controlled environment is provided.
8133679 Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast  
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and...
US20120059697 ADVERTISING DURING ACCELERATED MEDIA PLAYBACK  
A system and a method are disclosed for displaying an image during an operation of an accelerated media playback (e.g., fast-forward or reverse) such that the image appears concurrently with a cue...
US20120059021 COMPOSITIONS AND METHODS FOR TREATING CANCER AND METHODS FOR PREDICTING A RESPONSE TO SUCH TREATMENTS  
The present disclosure relates to the regulation and function of the Wnt/β-catenin signaling pathway and the ERK signaling pathway. The disclosure provides methods of treatment for melanoma by ...
US20120055792 MSP NANOPORES AND RELATED METHODS  
Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins,...
8131336 Automated in vivo plaque composition evaluation  
A method for the automated segmentation of in vivo image data is disclosed. A region of carotid artery in a number of patients was imaged using MRI. Histological data for each imaged region was...
US20120052519 METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY  
Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.
US20120050738 VIRTUAL CORE FLOW CYTOMETRY  
A sheathless flow cytometry system is disclosed wherein a fluid containing particles of interest, for example cells, flows through a sensing region, and is illuminated in the sensing region with...
8126578 Clipped-waveform repair in acoustic signals using generalized linear prediction  
A method and system for optimally repairing a clipped audio signal. Clipping occurs when a waveform exceeds a dynamic range of a recording device. Portions of an audio signal exceeding the dynamic...
8126527 Method and system for determining the contribution of hemoglobin and myoglobin to in vivo optical spectra  
This document discusses, among other things, quantification of hemoglobin content, and therefore blood volume, of muscle. An analysis of the optical spectra can determine the ratio of hemoglobin...
US20120046242 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant ...
8119773 Compositions and methods for facilitating heme-iron export from cells  
The invention provides a high affinity heme-binding agent, which can be provided in the form of a pharmaceutical composition that includes, optionally, a pharmaceutically acceptable carrier. The...
US20120041073 STABILIZED MUTANT OPSIN PROTEINS  
Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.
US20120040916 MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by the Wnt/β-catenin pathway by selecting a subject with a condition mediated by the Wnt/β-catenin p...
US20120038881 FREE-STANDING TWO-SIDED DEVICE FABRICATION  
Solar cells attached to a contact lens are provided, as well as methods for making the solar cells and contact lenses. The solar cells have electrodes on only one side of the device, which...
8116705 Simplified high frequency tuner and tuning method  
A disclosed method tunes a signal from a channelized spectrum having a predetermined channel spacing. A signal of interest having a predetermined maximum bandwidth is mixed with a local oscillator...
8114187 Synthesis of platinum nanostructures  
A method for synthesizing noble metal nanostructures is disclosed. The method involves reacting under heat a noble metal precursor, a polyol reducing agent, and a stabilizing polymer. Morphological...
US20120028793 DUAL-OXIDE SINTER RESISTANT CATALYST  
A catalyst material for use at elevated temperatures is provided. The material can include a plurality of fibers and a plurality of particles supported on the fibers. In addition, a porous layer...
US20120027790 IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF  
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
US20120027789 ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME  
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic...
8105831 Parvoviral production of HLA homozygous cells  
The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods...