Patents and Patent Applications from University of Washington


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US20170299494 PARTICLE POSITIONING DEVICE WITH PERIODIC DIELECTRIC STRUCTURE  
Devices and techniques for a particle positioning device are generally described. In some examples, a fluid may be introduced to a channel formed on a first surface of a substrate. In various...
US20170296633 Compositions and Methods for Treating Celiac Sprue Disease  
The invention provides compositions and methods for treating celiac sprue.
9790536 Methods for assaying alpha-L-iduronidase enzymatic activity  
Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.
9790479 Therapeutic nuclease compositions and methods  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20170294015 SYSTEMS AND METHODS FOR QUANTITATIVE ASSESSMENT OF MICROVASCULATURE USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY  
A five-index quantitative analysis of OCT angiograms is disclosed. One method of analyzing an anatomical region of interest of a subject includes acquiring vascular image data from the region of...
US20170292160 Methods for Diagnosing and Treating Eye-Length Related Disorders  
The invention provides to methods for diagnosing eye-length related disorders, including myopia. The invention also provides methods for treating and limiting eye-length related disorders,...
US20170290992 Systems and Methods for Inhibiting Heterotopic Ossification  
Systems and methods for mitigating the formation of heterotopic ossification lesions by delivering a neuromuscular inhibitor employ a delivery device to distribute injection of the neuromuscular...
US20170290986 Ampule Autoinjector Systems And Methods  
An autoinjector is described that includes an outer body, a first trigger, an output needle, and a first compartment. The first compartment is positioned within the outer body and includes (i) a...
US20170290644 Medical Implant With Discontinuous Osseointigrative Surface  
A medical implant includes a base portion configured for implantation into a bone of a patient. The base portion is formed from an electrically insulating and biocompatible base material with...
9786469 Thin-ice grid assembly for cryo-electron microscopy  
A grid assembly for cryo-electron microscopy may be fabricated using standard nanofabrication processes. The grid assembly may comprise two support members, each support member comprising a...
9784730 Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine  
Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods...
US20170283475 CANCER VACCINE COMPOSITIONS AND METHODS OF USE THEREOF  
The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include...
9778261 Porous membrane-binding peptides  
The present invention provides porous membrane-binding polypeptides, fusion proteins thereof, and methods for use of the polypeptides and fusion proteins in binding assays.
9775894 Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling  
Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid...
US20170276578 EXPANSION MICROSCOPY METHODS AND KITS  
Methods and kits useful in expansion microscopy are described. In particular, the present disclosure relates to methods and kits for expanding or enlarging fixed samples of interest for microscopy...
US20170275279 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE  
The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the inhibition of MetRS.
US20170274046 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISEASE  
Provided herein are methods, assays and compositions relating to the treatment of neurological diseases and disorders, particularly by modulating expression and/or activity of Bif-1.
US20170273699 ULTRASOUND BASED METHOD AND APPARATUS FOR STONE DETECTION AND TO FACILITATE CLEARANCE THEREOF  
Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the...
US20170273539 Phone Adapter for Flexible Laryngoscope and Rigid Endoscopes  
An adapter for endoscopy can operably connect camera features and light source features of a portable electronic device with a respective viewfinder and illumination element of a medical...
9773321 Visual representations of distance cartograms  
Technology for generating high perceptual-quality distance cartograms, which use geo-contextual anchors to avoid topological violations, is disclosed. A system can calculate the travel times...
9771395 Enhanced influenza hemagglutinin binders  
Designed polypeptides having the amino acid sequence of SEQ ID NQ: 1 are described that bind with high affinity and selectivity to the influenza hemagglutinin protein, and which can be used for...
9770710 Hydrogenation and disproportionation catalysis  
Improved catalytic methods are disclosed. The methods include both hydrogenation and disproportionation catalysis. While the reaction conditions for hydrogenation and disproportionation differ,...
US20170266350 FUNCTIONALIZED ZWITTERIONIC AND MIXED CHARGE POLYMERS, RELATED HYDROGELS, AND METHODS FOR THEIR USE  
Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge...
US20170266269 METHODS OF IDENTIFYING ANTIGENS FOR VACCINES  
The methods, processes, and systems described herein include identifying an epitope of a peptide that may elicit an immune response in a subject. Often the methods, systems and processes may...
9766255 Biosensors engineered from conditionally stable ligand-binding domains  
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond...
9765122 Theragnostic particles  
The present invention provides viral-based nanoparticles for therapeutic and diagnostic use, and methods for making and using the nanoparticles. Specifically, such nanoparticles comprise...
9765037 Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases  
Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the...
US20170260328 Methods for Solid Freeform Fabrication  
The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles of polymer materials using 3D printing. A syringe or an inkjet print head prints a...
9759544 Methods of reducing motion artifacts for optical coherence tomography angiography  
A method for reducing motion artifacts in optical coherence tomography (OCT) angiography images is disclosed. The method is applied to the intensity or complex OCT data prior to applying the...
US20170254887 SYSTEMS AND METHODS FOR MEASURING PRESSURE DISTRIBUTIONS OF ACOUSTIC BEAMS FROM ULTRASOUND SOURCES  
The present technology relates generally to receiving arrays to measure a characteristic of an acoustic beam and associated systems and methods. The receiving arrays can include elongated elements...
9754686 Plasma confinement system and methods for use  
A plasma confinement system is provided that includes a confinement chamber that includes one or more enclosures of respective helicity injectors. The one or more enclosures are coupled to ports...
9753542 Methods and systems for six-degree-of-freedom haptic interaction with streaming point data  
Methods, articles of manufacture, and devices related to generating six degree of freedom (DOF) haptic feedback are provided. A computing device can receive first depth data about an environment....
9752188 Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing  
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of...
9751923 Administration of DKK1 muteins to treat fibrosis  
The present disclosure provides molecules, compositions and methods for treating scarring in organs. The molecules, compositions and methods treat scarring by modulating the WNT, platelet-derived...
9750814 Polypeptides to inhibit epstein barr viral protein BHRF1 and B cell lymphoma family proteins  
The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and are thus useful for treating Epstein...
US20170250063 METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS  
The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes...
US20170249932 CONFINEMENT OR MOVEMENT OF AN OBJECT USING FOCUSED ULTRASOUND WAVES TO GENERATE ANULTRASOUND INTENSITY WELL  
A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a...
US20170248551 Inspection of Structures  
A method of detecting inconsistencies in a structure is presented. A pulsed laser beam is directed towards the structure. A plurality of types of ultrasonic signals is formed in the structure when...
US20170247687 ERROR DETECTION IN SEQUENCE TAG DIRECTED SUBASSEMBLIES OF SHORT SEQUENCING READS  
The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing,...
US20170247419 Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor  
The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.
US20170246805 Methods for Solid Freeform Fabrication  
The present invention provides high performance polymer (HPP) compositions, methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using molding or 3D...
US20170246311 PEPTIDES FOR BINDING ALTERNATIVELY ACTIVATED MACROPHAGES  
M2 macrophage-binding peptides and polymers and related methods of use are described.
US20170245874 BROADLY FOCUSED ULTRASONIC PROPULSION PROBES, SYSTEMS, AND METHODS  
Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an...
9746536 Interleaved black and bright blood imaging for interleaved dynamic contrast enhanced magnetic resonance imaging  
A magnetic resonance system (10), and corresponding method, image a subject using a conversion-free interleaved black and bright blood imaging (cfIBBI) sequence. A MR scanner (12) is controlled to...
9743909 Imaging bubbles in a medium  
A method for imaging a cavitation bubble includes producing a vibratory wave that induces a cavitation bubble in a medium, producing one or more detection waves directed toward the induced...
US20170240861 HUMAN PLURIPOTENT STEM CELL DERIVED ENDOCARDIAL ENDOTHELIUM  
Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of...
US20170240695 METATHESIS POLYMERIZATION METHODS  
The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to...
US20170239360 MICELLIC ASSEMBLIES  
Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
9742993 Extended depth of focus for high-resolution optical image scanning  
Methods and systems for acquiring and/or projecting images from and/or to a target area are provided. Such a method or system can includes an optical fiber assembly which may be driven to scan the...
9738780 Crosslinked mixed charge hydrogels  
Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making...