Patents and Patent Applications from University of Virginia


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US20170302270 METHOD AND APPARATUS FOR CURRENT/POWER BALANCING  
Aspects of the disclosure provide a system having a power circuit. The power circuit includes a first switch circuit having at least a first transistor and a second switch circuit having at least...
US20170300657 Computerized Event Simulation Using Synthetic Populations  
Systems, methods, and computer-readable media for simulating the course of an event are provided. A processing unit can receive attributes of a synthetic population and select a...
US20170298141 COMPOSITIONS AND METHODS FOR TREATING CANCER  
The present invention provides compositions for targeting SAS1B positive cancer cells using immunotoxin technology and discloses that kidney and pancreatic cancer cells are SAS1B positive, but not...
US20170298032 SPHINGOSINE KINASE INHIBITORS  
Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides compounds that are effective for inhibition of sphingosine kinase type 1,...
US20170296700 STEM CELL COMPOSITIONS, SYSTEMS AND USES THEREOF  
Described herein are stem cells and stem cell compositions that can be used to treat soft tissue injuries, including tendon and ligament injuries. Also described herein are cellular scaffolds that...
9792985 Resistive volatile/non-volatile floating electrode logic/memory cell  
A resistive floating electrode device (RFED) provides a logic cell or non-volatile storage or dynamic or static random access memory on an extremely compact matrix with individual cells scalable...
9790528 Production of lysergic acid by genetic modification of a fungus  
The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus)...
9789492 Cleaning and dewatering fine coal  
Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The...
US20170294833 Multiphase Coupled and Integrated Inductors with Printed Circuit Board (PCB) Windings for Power Factor Correction (PFC) Converters  
A power factor correction (PFC) power converter, particularly of a multiphase totem-pole or other topology presenting a switching bridge that can potentially provide bi-directional power transfer...
US20170293670 SEQUENTIAL PATTERN MINING WITH THE MICRON AUTOMATA PROCESSOR  
A hardware accelerated solution of the SPM (Sequential Pattern Mining) is proposed using Micron's Automata Processor (AP), a hardware implementation of non-deterministic finite automata (NFAs) The...
US20170291139 CARBONATION OF METAL SILICATES FOR LONG-TERM CO2 SEQUESTRATION  
In a preferred embodiment, the invention relates to a process of sequestering carbon dioxide. The process comprises the steps of: (a) reacting a metal silicate with a caustic alkali-metal...
US20170290995 SYSTEMS AND METHODS FOR AUTOMATICALLY ADJUSTING NEEDLE PENETRATION DEPTH FOR AUTO-INJECTOR DEVICES  
Disclosed are various embodiments of an auto-injector device that automatically and dynamically adjusts the depth that a needle will penetrate into a target area of the body. In one embodiment,...
9786832 Energy harvester  
An energy harvester for converting vibration energy into electrical energy and harvesting the electrical energy includes: a base; a clamping structure which is supported by the base and is spaced...
US20170288607 BALANCED UNILATERAL FREQUENCY QUADRUPLER  
An integrated frequency quadruplet consists of a pair of balanced frequency doublers that are driven in phase quadrature using a hybrid coupler. This approach results, effectively, in a...
US20170287693 MONOLITHIC COLLIMATOR AND ENERGY ANALYZER FOR ION SPECTROMETRY  
Disclosed are various examples related to ion or particle spectrometry utilizing a monolithic collimator and energy analyzer. In one example, a particle selection device includes a single...
US20170281130 METHOD AND APPARATUS FOR ACCELERATED DISINTEGRATION OF BLOOD CLOT  
Systems and methods for treating a blood clot include a catheter to be inserted into a patient. The catheter is used to deliver low stability microbubbles toward the blood clot in the patient. A...
US20170281042 SYSTEMS AND METHODS FOR MAGNETIC RESONANCE THERMOMETRY USING BALANCED STEADY STATE FREE PRECESSION  
Some aspects of the present disclosure relate to systems and methods for magnetic resonance thermometry. In one embodiment, a preliminary balanced steady state free precession (bSSFP) magnetic...
9778112 Segmented chirped-pulse Fourier transform spectroscopy  
An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a...
9777123 Sulfated beta-O4 low molecular weight lignins  
Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.
US20170279471 Transmitting Wideband Signals Through an Electrically Small Antenna Using Antenna Modulation  
The present invention provides methods and devices to radiate wideband signals. The devices may include a tunable high Q narrowband antenna having a plurality of ports including a feed port and a...
US20170273607 ACCURACY CONTINUOUS GLUCOSE MONITORING METHOD, SYSTEM, AND DEVICE  
A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time...
9773967 Processing method for grain-oriented lead-free piezoelectric Na0.5Bi0.5TiO3—BaTiO3 ceramics exhibiting giant performance  
Textured ceramic compositions having improved piezoelectric characteristics as compared with their random counterparts are provided. Methods of making the compositions and devices using them are...
9773594 Non-rare earth magnetic nanoparticles  
Continuous flow synthetic methods are used to make single phase magnetic metal alloy nanoparticles that do not contain rare earth metals. Soft and hard magnets made from the magnetic nanoparticles...
9771400 Photoactive silk protein and fabrication of silk protein structures using photolithography  
A natural protein, specifically silk fibroin or sericin, is chemically modified such that it can be rendered photoactive, but which otherwise has similar structure and attributes as silk fibroin...
9770349 Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation  
The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or...
US20170269080 OMPA IN VACCINE COMPOSITIONS AND AS DIAGNOSTIC TARGETS  
Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born...
US20170269048 PORTABLE ALCOHOL TESTER  
A portable electronic alcohol-testing device is provided that uses vaporization and sensitive pressure guages to approximate the alcohol content of a solution. The device may be used, for example,...
US20170268095 Physical vapor deposition on doublet airfoil substrates:controlling the coating thickness  
A method and system of depositing a coating on a substrate and/or simulating depositing a coating on a substrate.
US20170266438 SELECTIVE MODULATION OF INTRACELLULAR EFFECTS OF CELLS USING PULSED ELECTRIC FIELDS  
A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive...
D797944 Hands free breastfeeding aid  
9768355 Production of graphene and nanoparticle catalysts supported on graphene using laser radiation  
Methods and apparatuses to produce graphene and nanoparticle catalysts supported on graphene without the use of reducing agents, and with the concomitant production of heat, are provided. The...
9765017 Allosteric hemoglobin modifiers with nitric oxide releasing moiety  
Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the...
9764958 Process for pure carbon production, compositions, and methods thereof  
The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure...
9763894 Inflammation therapy  
A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid...
US20170260146 A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION  
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units...
US20170260128 Water Soluble Haloanilide Calcium-Release Calcium Channel Inhibitory Compounds and Methods to Control Bone Erosion and Inflammation Associated with Arthritides  
A compound that is selected from the group consisting of 3-(3,4-dichloroanilino)-3-oxopropanoic acid (hereinafter “DCOPA”); N-methyl-DCOPA; N,2-dimethyl-DCOPA; 2-methyl-DCOPA; isobutyl-DCOPA;...
US20170258424 ViRPET - COMBINATION OF VIRTUAL REALITY AND PET BRAIN IMAGING  
Various methods, systems and apparatus are provided for brain imaging during virtual reality stimulation. In one example, among others, a system for virtual ambulatory environment brain imaging...
9761154 Tracheostomy trainer device and related method thereof  
A training device and related method designed to provide a user or trainee with a realistic tactile sensation or feel for inserting a penetrating device, such as a tracheotomy tube, into the stoma...
9758459 Allosteric modulators of factor XIa as anticoagulant agents  
Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated...
US20170255252 SELECTIVE WAKEUP OF DIGITAL SENSING AND PROCESSING SYSTEMS USING RECONFIGURABLE ANALOG CIRCUITS  
According to some embodiments, a sensor network may be provided with re-programmable and/or reconfigurable analog circuitry configured to monitor data collected by the sensor network. The...
US20170253712 Gelation, Aerogel Formation and Reactions Thereof to Produce Non-Random Functionalization of Poly (Aryl Ether Ketones)  
The present invention provides a gel comprising a physical network formed of polymer chain crystallites interconnected by amorphous chain segments. Functionalization of the chain segments between...
US20170253648 Compositions and Methods for Prophylaxis and/or Therapy of Disorders that Correlate with DENND1A Variant 2  
Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for...
US20170252463 UNIT DOSAGE OF APADENOSON  
The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
US20170252422 STAGE SPECIFIC DIAGNOSTIC ANTIGENS, ASSAY AND VACCINE FOR LYME DISEASE  
Stage-specific Borrelia antigens for diagnosing, treating and/or preventing Lyme disease are provided. The antigens include chimeric Borrelia antigen constructs and mutant recombinant proteins...
US20170252355 OXYGENATED CHOLESTEROL SULFATES FOR THERAPY OF DISORDERS CAUSED BY AT LEAST ONE OF ATTENUATED LEPTIN ACTIVITY AND A LIPID STORAGE DISORDER  
Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin activity and by lipid storage...
9750823 Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics  
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1...
9750438 CGM-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction of insulin delivery  
An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto,...
US20170250444 HALOGEN-FREE ELECTROLYTES  
Compounds (salts) for use as electrolytes, e.g. in batteries such as Li ion, Na ion and Mg ion batteries are provided. The negative ions (anions) of the compounds are complex molecules which do...
US20170250083 QUASI-VERTICAL DIODE WITH INTEGRATED OHMIC CONTACT BASE AND RELATED METHOD THEREOF  
A quasi-vertical Schottky diode architecture includes a topside anode contact that connects to external circuitry through an airbridge finger, a thin mesa of semiconductor material with epilayers...
US20170246282 MULTIVALENT BRUCELLA VACCINE FOR PROTECTION AGAINST MYCOBACTERIAL INFECTIONS AND METHODS OF USING THE SAME  
Provided herein is a multivalent Brucella vaccine expressing at least one heterologous M. tuberculosis antigen. The vaccines described herein serve as an environmentally safe bivalent vaccine for...