Patents and Patent Applications from University of Virginia


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US20180016317 COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES AND DISORDERS  
The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or...
9870531 Analysis system using brokers that access information sources  
Systems, methods, and computer-readable media for generating a data set are provided. One method includes generating a data set based on input data using a plurality of brokers. The method further...
9867652 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds  
The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of...
9865713 Extremely large spin hall angle in topological insulator pn junction  
The interplay between chiral tunneling and spin-momentum locking of helical surface states leads to spin amplification and filtering in a 3D Topological Insulator (TI). Chiral tunneling across a...
9861324 Hybrid detector modules and dynamic thresholding for spectral CT  
A system and method that comprises an X-ray source configured to emit an X-ray beam; an object positioned to receive the X-ray beam; a detector configured to receive an attenuated beam of the...
US20180006644 PARALLEL DEVICES HAVING BALANCED SWITCHING CURRENT AND POWER  
A power circuit includes a power source for providing electrical power and two driving transistors being disposed in parallel and receiving electrical power from the power source. Each of the two...
US20180003151 MORPHING SEGMENTED WIND TURBINE AND RELATED METHOD  
A downwind morphing rotor that exhibits bending loads that will be reduced by aligning the rotor blades with the composite forces. This reduces the net loads on the blades which therefore allow...
9855327 Live attenuated chimeric porcine circovirus vaccine  
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a...
US20170371635 SYSTEM, METHOD AND COMPUTER READABLE MEDIUM FOR SPACE-EFFICIENT BINARY REWRITING  
According to some illustrative embodiments of the invention, a method is performed that includes using a representation of a computer software program, using identified addresses which correspond...
US20170369915 Production Of Lysergic Acid By Genetic Modification Of A Fungus  
The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus)...
US20170368143 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING INFECTION  
The present invention encompasses compositions and methods useful to treat or prevent Clostridium difficile antibiotic-associated colitis through administration of IL-25 and/or downstream...
9850221 Sulfated and unsulfated flavonoid oligomers as cancer therapeutics  
Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and...
US20170366086 METHODS AND APPARATUS FOR A SINGLE INDUCTOR MULTIPLE OUTPUT (SIMO) DC-DC CONVERTER CIRCUIT  
In some embodiments, an apparatus includes a single-inductor multiple-output (SIMO) direct current (DC-DC) converter circuit, with the SIMO DC-DC converter circuit having a set of output nodes....
US20170362491 SYSTEM AND RELATED METHOD TO SEAL FRACTURED SHALE  
A method of pumping a fluid and reactive solid into a mineral formation includes the fluid reacting with the mineral formation to produce a nucleation product. The method may be used in shale...
US20170362363 COMPOSITIONS AND METHODS FOR BONDING GLUES, ADHESIVES, AND COATINGS TO SURFACES  
The present application provides compositions and methods for allowing surfaces such as HDPE, LDPE, polyethylene, polypropylene, Teflon (polytetrafluoroethylene), SBS, SEBS, SIS elastomers, and...
US20170362181 CHELATION DIRECTED C-H ACTIVATION REACTIONS CATALYZED BY SOLID-SUPPORTED PALLADIUM(II) CATALYSTS  
Chelation directed C—H activation reactions that are catalyzed by Pd(11) on Multi-Walled Carbon Nanotubes (MWCNT), Single-Walled Carbon Nanotubes (SWCNT), or graphene are provided. The reactions...
US20170360562 Three-Dimensional Pre-Vascularized Scaffold for Bone Regeneration  
The present invention provides scaffolds comprising dual structural organization for bone and regeneration. Methods for fabricating and using the scaffold are also disclosed.
US20170360460 METHOD AND APPARATUS FOR ACCELERATED DISINTEGRATION OF BLOOD CLOT  
Systems and methods for treating a blood clot include a catheter to be inserted into a patient. The catheter is used to deliver low stability microbubbles toward the blood clot in the patient. A...
US20170360326 DEVICES, SYSTEMS, AND METHODS FOR REAL-TIME MONITORING OF ELECTROPHYSICAL EFFECTS DURING TISSUE TREATMENT  
Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy. Provided herein are embodiments of an...
9847710 Universal system structure for low power adapters  
A two-stage power converter architecture including an isolation transformer and rectification of the isolation transformer output by an LLC resonant circuit and methodology for operating the same...
9845465 Compositions and methods for treating peripheral arterial disease  
The present application discloses roles for miR-93 in treating hypoxia and ischemia. Endothelial cells (HUVEC) and myocytes (C2C12) expressed miR-93 and up-regulated miR-93 in response to hypoxia...
US20170356884 Systems and Methods for Multispectral Photoacoustic Microscopy  
A reflection-mode multispectral photoacoustic microscopy (PAM) system and related method is disclosed, based on an optical-acoustic objective in communication with an ultrasonic transducer. In...
US20170356773 SYSTEM AND METHOD OF NON-INTRUSIVE ANEMOMETRY  
A system and method of non-intrusive anemometry. The system comprises an acoustic transmitter disposed at a boundary of fluid flow and first and second acoustic receivers adapted to receive...
9840545 Fusion protein comprising interleukin-2 and interleukin-33  
The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or...
9839364 Ventricular activation (RR) entropy change as a predictor of sudden cardiac death in cardiac resynchronization therapy patients  
A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a...
9839200 Walkway device and method for quantitative analysis of gait and its modification in rodents  
A system and method for quantitatively assessing the changes in control of asymmetric locomotor behavior of an animal comprising analyzing the phase modulation in response to imposed asymmetric...
US20170348631 Amino Acids React with Carbon Dioxide (CO2) and Form Nanofibers and Nanoflowers  
A method for capturing CO2 comprising dissolving at least one pure amino acid (AA) in water without the use of a catalyst for establishing protonation of an amino group of the amino acid, adding...
US20170344438 MICROPROCESSOR FAULT DETECTION AND RESPONSE SYSTEM  
Aspects disclosed in the detailed description include a microprocessor fault detection and response system. The microprocessor fault detection and response system utilizes a hardware-based...
US20170343635 Reduced Field-of-View Perfusion Imaging With High Spatiotemporal Resolution  
Some aspects of the present disclosure relate a method for magnetic resonance imaging, which can include acquiring, by applying an imaging pulse sequence, magnetic resonance data associated with a...
US20170337348 METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR CGM-BASED PREVENTION OF HYPOGLYCEMIA VIA HYPOGLYCEMIA RISK ASSESSMENT AND SMOOTH REDUCTION INSULIN DELIVERY  
An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto,...
US20170334994 COMPOSITIONS AND METHODS FOR TREATING CLOSTRIDIUM DIFFICILE INFECTION  
Clostridium difficile is the most common hospital acquired pathogen in the United States, and infection is in many cases fatal. Toxins A and B are its major virulence factors, but increasingly a...
US20170333541 TARGET PEPTIDES FOR IMMUNOTHERAPY AND DIAGNOSTICS  
A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an...
9825653 Cognitive reconfigurable RF technology  
The present invention provides a radio architecture that contains a main radio path and a sensing path. The parameters of the main radio path are controlled by a cognitive engine. The main radio...
9822154 Immune modulator for immunotherapy and vaccine formulation  
A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170...
9821084 Hemostasis of wound having high pressure blood flow using kaolin and bentonite  
Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when...
US20170328972 DETECTING SIGNAL CHANGES IN HEATED BONE WITH A 3D SPIRAL ULTRA-SHORT ECHO TIME SEQUENCE  
In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the...
US20170326166 COMPOSITIONS AND METHODS FOR TREATING PITUITARY TUMORS  
The present application discloses that pituitary tumor cells are sensitive to low concentrations of glucose and that methods of treating such tumors include methods to induce infarction that are...
US20170326086 USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES  
Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas...
US20170322227 COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE  
The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a...
US20170322226 COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE  
The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a...
US20170321422 DURABLE, FIRE RESISTANT, ENERGY ABSORBING AND COST-EFFECTIVE STRENGTHENING SYSTEMS FOR STRUCTURAL JOINTS AND MEMBERS  
The disclosed technology is a system and a method for strengthening one or more joints of a structure having a plurality of structural members forming a vacuous area at each joint. The method...
US20170320742 PROCESS FOR PURE CARBON PRODUCTION, COMPOSITIONS, AND METHODS THEREOF  
The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure...
US20170320741 PROCESS FOR PURE CARBON PRODUCTION  
The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for...
US20170319843 APPARATUS FOR GENERATING ELECTRICAL PULSES AND METHODS OF USING THE SAME  
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an...
9812978 Circuit and method for driving synchronous rectifiers for high-frequency flyback converters  
A voltage waveform similar to a waveform of a magnetizing current of an isolation transformer and immune to high frequency oscillatory resonant behavior is developed across a capacitor of a series...
9812965 Low input voltage boost converter with peak inductor current control and offset compensated zero detection  
The low input voltage boost converter with peak inductor current control and offset compensated zero detection provide a boost converter scheme to harvest energy from sources with small output...
9811924 Interferometric techniques for magnetic resonance imaging  
A method and system for providing a fast image reconstruction of magnetic resonance spectroscopic imaging (MRSI) data based on applying, at least in part, interferometric techniques using a single...
US20170316324 Computerized Event-Forecasting System and User Interface  
Systems, methods, and computer-readable media for simulating the course of an event or for collecting data for the simulation are provided. A processing unit can receive attributes of synthetic...
US20170313828 IN SITU-FORMING OF DENDRIMER HYDROGELS USING MICHAEL-ADDITION REACTION  
A method of forming a dendrimer hydrogel, the method comprising providing one or more amine end-functioned polyamidoamine (PAMAM) as a first reactant; providing one or more small molecule,...
US20170313825 POLYCARBONATE-POLYOLEFIN BLOCK COPOLYMERS AND METHODS OF MAKING THEM  
A polycarbonate-polyolefin block copolymer and a process to form a polycarbonate-polyolefin block copolymer by combining mono- or di-hydroxyaryl with vinyl/vinylidene terminated polyolefin to form...