Patents and Patent Applications from University of Virginia


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US20120130698 System, Method and Computer Simulation Environment For In Silico Trials in Pre-Diabetes and Type 2 Diabetes  
An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose...
US20120128571 CARBONATION OF METAL SILICATES FOR LONG-TERM CO2 SEQUESTRATION  
In a preferred embodiment, the invention relates to a process of sequestering carbon dioxide. The process comprises the steps of: (a) reacting a metal silicate with a caustic alkali-metal hydroxide...
US20120123461 ACCESS TROCAR AND RELATED METHOD THEREOF  
System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method...
8179216 Capillary force actuator device and related method of applications  
An actuator capable of generates force by leveraging the changes in capillary pressure and surface tension that result from the application of an electrical potential. The device, which will be...
8178545 Dual small molecule inhibitors of cancer and angiogenesis  
The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule...
8178509 Method to treat sickle cell disease  
The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount of an A2A adenosine...
8176635 Manufacture of lattice truss structures from monolithic materials  
Methods and systems to manufacture lattice-based sandwich structures from monolithic material. Such methods and systems eliminate the bonding process which is conventionally used to join lattice...
US20120115149 SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM  
The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). T...
8173710 Bicyclic sphingosine 1-phosphate analogs  
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
8173007 High temperature electrochemical characterization of molten metal corrosion  
A system and method for the high temperature in-situ determination of corrosion characteristics of a molten metal on an alloy under study is provided which takes place within an insulated furnace....
8172998 Ionic solvents used in ionic polymer transducers, sensors and actuators  
Ionic liquids are incorporated into transducers, actuators or sensors which employ the ionic polymer membranes. The ionic liquids have superior electrochemical stability, low viscosity and low...
8172769 Method and apparatus for monitoring intra ocular and intra cranial pressure  
A method and apparatus for measuring acoustic energy applied to the head to detect increases in intracranial pressure. Acoustic eye patches are applied to a patient's eye or eyelid, and an...
US20120108463 COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DETERGENT STABILITY SCREEN  
The invention provides methods to assess protein stability and to obtain sizing information. In one aspect, the screen comprises a 94 detergent panel and a series of MWCO filtered microplates. A...
US20120101518 DePond clamp  
A first embodiment can be a clamp for gripping viscera comprising a pair of arms, each arm including a proximal handle and a distal tissue engaging member, pivot means interconnecting said arms,...
US20120094305 Methods For Treating And Diagnosing Fibrotic And Fibroproliferative Diseases  
The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease. In one embodiment the diagnostic method comprises determining the amount of circulating...
8158604 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof  
The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
US20120087553 MULTI-RESOLUTIONAL TEXTURE ANALYSIS FINGERPRINT LIVENESS SYSTEMS AND METHODS  
Various systems, methods, and programs embodied in computer-readable mediums are provided for fingerprint liveness detection. In one embodiment, a method for determining fingerprint liveness is...
8152895 Production of magnesium metal  
A process of producing magnesium metal includes providing magnesium carbonate, and reacting the magnesium carbonate to produce a magnesium-containing compound and carbon dioxide. The...
US20120079612 Dry eye animal model  
A first embodiment is a dry eyed animal model method by peri or post-menopausal estrogen-treated rats have decreased tear production wherein the menopausal rat may be produced by ovariectomy...
US20120078067 System Coordinator and Modular Architecture for Open-Loop and Closed-Loop Control of Diabetes  
A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to...
US20120065104 COMPOSITIONS AND METHODS FOR A MEMBRANE PROTEIN CRYSTALLIZATION SCREENING KIT  
The present invention comprises compositions and methods useful as a system for efficiently determining conditions that result in the formation of crystals of membrane proteins from solutions...
8135548 Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors  
A computer implemented method for receiving a plurality of analyte sensor related signals, determining a probability of signal attenuation associated with the received plurality of analyte sensor...
US20120059353 CGM-Based Prevention of Hypoglycemia Via Hypoglycemia Risk Assessment and Smooth Reduction of Insulin Delivery  
An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a...
US20120059003 INHIBITORS OF INV(16) LEUKEMIA  
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (AML). The inv(16) fusion results in ...
US20120056116 ELECTROSTATIC ACTUATION FOR MANAGEMENT OF FLOW IN MICRO-TOTAL ANALYSIS SYSTEMS (u-TAS) AND RELATED METHOD THEREOF  
In an example, an apparatus, such as a microfluidic assembly, can include or can include using a channel including a valve seat, a valve film configured to adjust position with respect to the valve...
US20120053460 Ultrasound Imaging Beam-Former Apparatus and Method  
In some illustrative embodiments, an incoming signal from a transducer in an ultrasound imaging beam-former apparatus is applied to an in-phase sample-and-hold and a quadrature sample-and-hold. The...
US20120052517 METHODS FOR TESTING AN IMMUNE RESPONSE USING CULTURES OF T CELLS, B CELLS AND DENDRITIC CELLS  
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic...
US20120050683 Self-Illuminated Handheld Lens for Retinal Examination and Photography and Related Method thereof  
System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and...
8124178 Method and apparatus application of metallic alloy coatings  
A directed vapor deposition (DVD) method and system for applying at least one bond coating on at least one substrate for thermal barrier coating systems. To overcome the limitations incurred by...
US20120045329 METHOD FOR CIRCULATION CONTROLLED VERTICAL AXIS AND TURBINES  
A method of controlling a vertical axis wind turbines using circulation control is presented. The comprising monitoring environmental conditions and the vertical axis wind turbine to determine a...
8119984 Method and apparatus for generation of reagent ions in a mass spectrometer  
A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a...
8114976 Cryptosporidium hominis genes and gene products for chemotherapeutic, immunoprophylactic and diagnostic applications  
Cryptosporidium hominis genes and gene products are provided. The genes and gene products are useful for chemotherapeutic, immunotherapeutic, immunoprophylactic and diagnostic applications.
8114608 Methods for treating and diagnosing fibrotic and fibroproliferative diseases  
The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease.
8114374 Carbonation of metal silicates for long-term CO2 sequestration  
In a preferred embodiment, the invention relates to a process of sequestering carbon dioxide. The process comprises the steps of: (a) reacting a metal silicate with a caustic alkali-metal hydroxide...
8111860 Recreational bone conduction audio device, system  
A waterproof recreational audio device and method that transmits sound via transcutaneous bone conduction provides high fidelity musical signals to a user. The device can be worn on the head of a...
8110043 Apparatus and method for applying coatings onto the interior surfaces of components and related structures produced therefrom  
A methodology and system for applying coatings onto the interior surfaces of components, includes a vapor creation device, a vacuum chamber having a moderate gas pressure and an inert gas jet...
US20120029397 TUMOR TREATMENT USING ULTRASOUND CAVITATION  
Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of...
US20120029356 Efficient architecture for 3D and planar ultrasonic imaging - synthetic axial acquisition and method thereof  
An improved device and method for collecting data used for ultrasonic imaging. The data is gathered over numerous transmit and echo receive cycles, or iterations and combined into a synthetic...
US20120029266 ANISOTROPIC REINFORCEMENT AND RELATED METHOD THEREOF  
Anisotropic reinforcements and synthetic materials are provided in which the fibers, mesh, weave, or otherwise interlaced or networked components thereof are oriented in one direction so as to...
US20120021439 SERIAL MULTIPLE ANTIGEN COLOCALIZATION IN PARAFFIN-EMBEDDED TISSUE  
The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single...
US20120014792 CIRCULATION CONTROLLED VERTICAL AXIS WIND TURBINE  
A circulation controlled vertical axis wind turbine is presented. The circulation controlled vertical axis wind turbine comprise one or more airfoils in communication with the turbine via a...
8098906 Regional fingerprint liveness detection systems and methods  
Various systems, methods, and programs embodied in computer-readable mediums are provided for fingerprint liveness detection. In one embodiment, a method for determining fingerprint liveness is...
US20120010187 BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS  
The invention provides FIG. 1 novel antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit antibacterial and antiparasitic action against a wide range of human pathogens....
US20120006335 Hip Continuous Passive Motion Device and Related Methods  
A system for providing continuous passive motion of a subject's leg through hip extension and flexion. The system may have an actuator, a leg support member, a retention surface, and a base. The...
8094907 System, method and computer program product for fast conjugate phase reconstruction based on polynomial approximation  
A fast conjugate phase reconstruction method for MRI is based on a polynomial expansion of the off-resonance phase accrual term. The expansion is truncated and can be a Taylor or Chebyshev expansion.
8093782 Specialized, high performance, ultrasound transducer substrates and related method thereof  
Backing substrates for reducing parasitic echoes produced within a ultrasonic transducer are provided comprising a polymeric material, for example, an epoxy having a glass transition temperature...
US20120004512 Method, System, and Computer Program Product For The Evaluation of Glycemic Control in Diabetes From Self-Monitoring Data  
A method, system, and computer program product related to the diagnosis of diabetes, and is directed to predicting the long-term risk of hyperglycemia, and the long-term and short-term risks of...
US20120003090 AIRFOIL FOR CIRCULATION CONTROLLED VERTICAL AXIS WIND TURBINES  
A airfoil blade for vertical axis wind turbines is presented. The airfoil blade comprises an internal cavity, an upper blowing slot disposed on the airfoil blade, and a lower blowing slot on the...
8090163 Multi-resolutional texture analysis fingerprint liveness systems and methods  
Various systems, methods, and programs embodied in computer-readable mediums are provided for fingerprint liveness detection. In one embodiment, a method for determining fingerprint liveness is...
US20110318650 Inorganic Solid Electrolyte Glass Phase Composite and a Battery Containing an Inorganic Solid Electrolyte Glass Phase Composite  
An inorganic solid electrolyte glass phase composite is provided comprising a substance of the general formula La2/3-xLi3xTiO3 wherein x ranges from about 0.04 to about 0.17, and a glass material....