Patents and Patent Applications from University of Virginia


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US20180107931 Complex Situation Analysis System Using a Plurality of Brokers that Control Access to Information Sources  
Systems, methods, and computer-readable media for generating a data set are provided. One method includes generating a data set based on input data using a plurality of brokers. The method further...
US20180105779 Optical Density System and Related Method thereof  
An apparatus and related method for determining the optical density and/or change in optical density of a reaction mixture in an agitated vessel or container. The apparatus may include at least...
US20180105562 IMMUNE MODULATOR FOR IMMUNOTHERAPY AND VACCINE FORMULATION  
A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170...
9947994 Time-variant antenna module for wireless communication devices  
A plug-and-play antenna may be used with many different types of wireless communication devices. An antenna may be coupled to an impedance tuning component and a waveform generator. A calibration...
9945851 OmpA in vaccine compositions and as diagnostic targets  
Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born...
9944618 Inhibiting neurotransmitter reuptake  
This document relates to compounds as well as methods and materials involved in modulating neurotransmitter reuptake. For example, compounds, methods for synthesizing compounds, and methods for...
9944597 Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof  
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic...
9943684 Nanosecond pulsed electric fields cause melanomas to self-destruct  
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the...
9943347 Medial column (MECO) fixation device, method, and system  
An orthopedic implant device and system support the fusion of bones in the medial column of the human foot. An exemplary implant uses an improved lag screw and supplemental components, including a...
9942262 Cyber-physical system defense  
System and techniques for cyber-physical system defense are described herein. Sensor disagreements between a plurality of sensors over time can be sampled. Cluster analysis on the sampled sensor...
9941838 Low voltage crystal oscillator (XTAL) driver with feedback controlled duty cycling for ultra low power  
A low voltage crystal oscillator (XTAL) driver with feedback controlled duty cycling for ultra low power biases an amplifier for an XTAL in the sub-threshold operating regime. A feedback control...
9937234 Compositions and methods for using and identifying antimicrobial agents  
As disclosed herein methods are provided to identify compounds with antimicrobial activity, and methods for treating subjects by administering the compounds. In particular, the invention provides...
US20180097538 ULTRA LOW POWER SENSING PLATFORM WITH MULTIMODAL RADIOS  
An apparatus comprises a system on a chip (SoC). In some embodiments, the SoC includes a power supply circuit, a power management circuit operatively coupled to the power supply circuit, a first...
US20180094137 COMPOSITIONS AND METHODS FOR THE DELIVERY OF DRUGS TO THE OCULAR SURFACE BY CONTACT LENSES  
Disclosed herein are novel methods and compositions for targeting ocular diseases. One aspect relates to a contact lens comprising an elastin-like peptide (ELP) component and optionally a...
9932288 Chemical compound for inhibition of SHP2 function and for use as an anti-cancer agent  
This invention provides a compound that is 4,4′-(4′-Carboxy)-4-nonyloxy-[1,1′-biphenyl]-3,5-diyl)dibuta noic acid (CNBDA), derivative compounds of CNBDA, and pharmaceutical compositions thereof....
9931784 3D printing part removal and interface for a 3D printing vending machine  
The present invention concerns a system and method for fabricating a three-dimensional object. A build platform is provided that defines a build area and includes a print bed within the build...
9931125 Device for control of difficult to compress hemorrhage  
Bleeding from blood vessels located in difficult-to-compress regions of the body (especially the abdomen, pelvic or groin region) is controlled by the use of a portable, small-footprint belt-like...
9931086 Apparatus and method for breast immobilization  
This application discusses, among other things, curved plates for immobilizing a breast of a subject for medical imaging. In an example, an immobilization assembly Can include a curved compression...
9929332 Flexible thermoelectric devices, methods of preparation thereof, and methods of recovering waste heat therewith  
The present disclosure relates to flexible thermoelectric devices. In some embodiments, such devices can comprise a flexible substrate with a first conductive component and a second, different...
9926589 Identification and quantification of multiple nucleic acid targets in complex mixtures  
A complex mixture is analyzed for multiple nucleic acid sequences (e.g., DNA or RNA sequences) simultaneously by target specific multiplex amplification followed by single molecule detection of...
9926290 Inhibitors of INV(16) leukemia  
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (AML). The inv(16) fusion results in...
9924923 Ultrasound imaging of specular-reflecting target  
Ultrasound apparatus or techniques can include obtaining reflected ultrasound echo information, which can be used to construct a two-dimensional or three-dimensional representation of an at least...
9924913 ViRPET—combination of virtual reality and PET brain imaging  
Various methods, systems and apparatus are provided for brain imaging during virtual reality stimulation. In one example, among others, a system for virtual ambulatory environment brain imaging...
9923560 Method and apparatus for current/power balancing  
Aspects of the disclosure provide a system having a power circuit. The power circuit includes a first switch circuit having at least a first transistor and a second switch circuit having at least...
9922238 Apparatuses, systems, and methods for confirming identity  
A system, apparatus, and method for confirming the identity of a person for access using an image of that person. The system includes a camera, a data storage device, a subject identification...
9921170 Apparatus and techniques for Fourier transform millimeter-wave spectroscopy  
Examples herein include apparatus and techniques that can be used to perform rotational spectroscopy on gas-phase samples. Such techniques can include using a spectrometer providing frequency...
9921037 Hybrid periodic cellular material structures, systems, and methods for blast and ballistic protection  
Structures based upon periodic cellular materials that provide a potential for defeating combinations of both air blast loading and ballistic attack either sequentially or simultaneously, or...
9920530 Heat-managing composite structures  
Light-weight, heat-managing structures feature open-cell lattice, honeycomb, and/or corrugated (prismatic) arrangements in their substructures, combined with heat pipe/heat plate arrangements for...
US20180076915 Method for Jointly Adapting an OFDM Waveform and the Demodulator for Interference Mitigation and Harsh Channels  
The present invention provides a method and system for a processing multicarrier signal to create a spectral correlation across multiple antennas. The system includes at least one transmitter...
US20180076723 VARIABLE DC LINK CONVERTER AND TRANSFORMER FOR WIDE OUTPUT VOLTAGE RANGE APPLICATIONS  
A variable direct current (DC) link power converter is described. In one example, the power converter includes a first converter stage configured to convert power from a power source to power at...
US20180070886 METHOD, SYSTEM, AND COMPUTER READABLE MEDIUM FOR GENERATING PULSE OXIMETRY PREDICTIVE SCORES (POPS) FOR PREDICTING ADVERSE OUTCOMES IN PRETERM INFANTS  
A method and system for generating pulse oximetry predictive scores for predicting adverse outcomes in preterm infants.
9916416 System and method for genotyping using informed error profiles  
A system and method for genotyping tandem repeats in sequencing data. The invention uses Bayesian model selection guided by an empirically-derived error model that incorporates properties of...
9914362 Energy storage for power factor correction in battery charger for electric-powered vehicles  
Switches of a switching circuit used to control operation of an electric motor such as in an electrically powered vehicle connect respective windings of the electric motor as a single phase...
US20180066052 COMPOSITIONS AND METHODS FOR REGULATING SAS1R  
The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm...
US20180065116 CATALYSTS AND METHODS FOR FORMING ALKENYL AND ALKYL SUBSTITUTED ARENES  
Embodiments of the present disclosure provide for Rh(I) catalysts, methods of making alkenyl substituted arenes (e.g., allyl arene, vinyl arene, and the like), methods of making alkyl substituted...
US20180064931 DEVICES AND METHODS FOR REPAIRING DAMAGE TO A NERVE  
An example device for repairing a nerve is described herein. The device can include a flexible carrier layer made of a biologic material, and a metallic support member including a plurality of...
9910118 Systems and methods for cartesian dynamic imaging  
Systems and methods for Cartesian dynamic imaging are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data for an area of...
9909222 Methods and apparatuses for production of carbon, carbide electrodes, and carbon compositions  
Method comprising providing at least one solid carbide chemical compound and reducing a metal cation with use of the solid carbide chemical compound. A method comprising producing elemental carbon...
9908849 Imidamide sphingosine kinase inhibitors  
Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
9908313 Process for bonding lignocellulosic substrates without an added adhesive and products thereof  
Processes for bonding lignocellulosic substrates without an added adhesive are described. The processes of the invention may include exposing the surfaces of the lignocellulosic substrate to a...
US20180055452 Method, System and Computer Readable Medium for Predictive Hypoglycemia Detection for Mild to Moderate Exercise  
A system, method and non-transient computer readable medium for predicting hypoglycemic risk in patients with diabetes following moderate exercise. A system may include a digital processor; and an...
US20180055351 Self-Illuminated Handheld Lens for Retinal Examination and Photography and Related Method thereof  
System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and...
9906431 Rapid localization platform for location based applications in self-organized networking systems  
Time-critical Location Based Service (LBS) applications in mobile ad hoc networks (MANETs) require fast localization. An On-Demand Fast Localization (ODFL) start from multi-coordinate systems, and...
US20180054140 INTERFACE CONVERTER COMMON MODE VOLTAGE CONTROL  
Aspects of interface converter common mode (CM) voltage control are described. In one embodiment, a bi-directional alternating current (AC) to direct current (DC) interface converter system...
US20180052051 SEGMENTED CHIRPED-PULSE FOURIER TRANSFORM SPECTROSCOPY  
An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a...
US20180050039 INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY  
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a...
9897605 Porcine torque teno virus vaccines and diagnosis  
The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and...
9896549 Hydrophobic and oleophobic coatings  
Provided according to some embodiments of the invention are hydrophobic and/or oleophobic silica-based coatings. In some embodiments of the invention, coatings may include a silica matrix having...
9895158 Method and apparatus for accelerated disintegration of blood clot  
Systems and methods for treating a blood clot include a catheter to be inserted into a patient. The catheter is used to deliver low stability microbubbles toward the blood clot in the patient. A...
US20180043585 DELIVERY OF PARTICLES USING HYGROSCOPIC EXCIPIENTS  
A method of delivering a therapeutic agent comprises providing an aerosol generator that produces an aerosol of particles or droplets containing a therapeutic agent and an excipient for delivery...