Patents and Patent Applications from University of Toledo


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9828615 Methods for high yield production of furans from biomass sugars at mild operating conditions  
Facile methods for high-yield furfural and HMF production from biomass sugars are described. The methods generally involve converting the biomass sugars in high yield to their ketose isomers,...
9821008 Inhibitors of ERCC1-XPF and methods of using the same  
Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to...
9814778 Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles  
Underwater adhesive materials, methods of making the same, and methods of using the same are described.
9809781 Thermal fractionation of biomass of non-lignocellulosic origin for multiple high-quality biofuels  
Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described. The products of said methods are also described.
9808299 Bioactive fusion device  
In a first broad aspect, there is provided herein a bioactive device and system for fusion between two bones, two parts of a bony joint, or a bony defect, such as of the spine. The fusion device...
US20170313972 High Yield Algal Biomass Production Without Concentrated CO2 Supply Under Open Pond Conditions  
Methods and systems for efficient culturing of algae in open ponds are described.
US20170311599 Target for Anthelmintic Development, and Anthelmintics Utilizing the Same  
Compounds, compositions, methods, materials, and transgenic animals for antihelmintic purposes are described.
9788541 Antibacterial surfactant/microgel formulations, methods of making and methods of using the same  
Formulations having, as active agents, at least one quaternized polymeric microgel and at least one surfactant, methods of making, and methods of using are described.
US20170292154 Methods For Determining Biological States By Assessing Amounts Of Target Nucleic Acids In A Sample  
Described herein are compositions for evaluating nucleic acids, standardized mixture for assessing amounts of at least one target nucleic acid in a sample, and kits comprising the same.
9782748 Synthesis of polymeric ionic liquids using a photochemical polymerization process  
Photo-initiated polymeric ionic liquids, methods of making and methods of using the same are disclosed. A preferred embodiment for making a photo-initiated polymeric ionic liquid (P-PIL) coated...
9782746 Polymeric ionic liquids, methods of making and methods of use thereof  
Polymeric ionic liquids, methods of making and methods of using the same are disclosed.
US20170283385 Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same  
Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing...
9765094 Ultrastable silver nanoparticles  
Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
US20170258369 LARYNGEAL MECHANOSENSOR STIMULATOR  
This invention is a device that provides feedback controlled pressure output that delivers a highly controlled and accurate air stimulus into the larynx for diagnostic use. The device is designed...
9750954 Concurrent delivery of interstitial thermobrachytherapy (hyperthermia and brachytherapy) in the treatment of cancer  
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
9743961 Bioactive fusion device  
A fusion device includes a screw having a head and a shaft. A hollow bone dowel is disposed about the shaft of the screw. The bone dowel is formed from a bone-like, biocompatible, or allograft...
US20170216623 Concurrent Delivery of Interstitial Thermobrachytherapy (Hyperthermia and Brachytherapy) in the Treatment Of Cancer  
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
9718052 Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby  
Bi-functional cobalt-containing catalysts useful for making stereospecific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure β-lactones...
US20170204051 Cross Metathesis Approach to C11-C13 Fatty-Chain Amino Esters From Oleic Acid Derivatives  
A concise method of producing nylon 11, 12, or 13 precursors from oleic acid or an ester of oleic acid is described. The method involves cross-metathesis reactions as the key C—C bond formation...
US20170196702 Apparatus and Method for Injecting Bone Graft Substitute and Other Materials  
A metering delivery apparatus for injecting bone graft cement includes a body portion, a material containment vessel, an actuator, and a control unit. The body portion includes a drive housing...
9695137 Analogs of peroxisome proliferator activated receptor (PPAR) agonists, and methods of using the same  
Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.
US20170173068 Wound Healing Agent Made From Low Acyl Gellan Gum, Methods of Making and Methods of Using the Same  
Described herein are materials and methods useful for the treatment of neurodegenerative disorders and bone disorders, as well as healing wounds, in a subject. Materials described herein include...
9683261 Standardized mixtures for assessing amounts of target nucleic acids in a sample, and kits therefore  
Described herein are compositions for evaluating nucleic acids, standardized mixture for assessing amounts of at least one target nucleic acid in a sample, and kits comprising the same.
9682246 System for concurrent delivery of thermobrachytherapy in the treatment of cancers  
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.
9675717 Electromagnetic polymer composite material for anti-fouling effect  
The antifouling coating is a composite material consisting of fluorinated electroactive bipolymers and magnetic particles. This composite material is coated on a solid surface to make a smooth...
US20170158640 Ring Closing Metathesis Approach To Produce Precursors Of Nylon 11, 12, And 13 From Oleic Acid  
Provided herein is a method of producing C11, C12, and C13 nylon precursors from oleic acid or esters of oleic acid, the method involving amide formation, ring-closing metathesis, and...
9668678 Integrated magneto-optic modulator/compensator system, methods of making, and methods of using the same  
Described herein is an integrated Faraday modulator and Faraday compensator (IFMC) system. Further described are methods of making an IFMC system, methods of customizing an IFMC system for a...
9663561 Methods of treatment of cancer using SRC-modulating peptides  
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for...
US20170128228 Minimally Invasive Collapsible Cage  
An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally...
US20170114097 Compositions and Methods of Treatment of Cancers  
Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
US20170101613 System for Simultaneous Isomerization and Fermentation of Sugars  
Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single...
US20170099838 Antibacterial Surfactant/Microgel Formulations, Methods of Making and Methods of Using the Same  
Formulations having, as active agents, at least one quaternized polymeric microgel and at least one nonionic surfactant, methods of making, and methods of using are described.
US20170088811 Microalgae Harvesting Using Stimuli-Sensitive Hydrogels  
A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
US20170072103 Biodegradable Magnesium Alloys and Composites  
Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.
US20170072037 Xenoantigen-Displaying Anti-Cancer Vaccines and Method of Making  
Compositions, methods of making, and methods of using, xenoantigen-displaying anti-cancer vaccines are described.
US20170035730 PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS  
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an...
9562266 Amine-terminated aptamer functionalized surface plasmon resonanace sensors, methods of making and methods of using same  
Sensors for target entities having functionalized thereon, at least one amine-terminated aptamer specific to the target entity, and methods of making and using the same are described.
9562210 Methods for production of fatty acid alkanolamides (FAAAs) from microalgae biomass  
Provided herein are methods for fatty acid alkanolamide (FAAA) synthesis and isolation from lipid-containing algal biomass, and the products of such methods.
9561115 Expandable inter-vertebral cage and method of installing same  
An inter-vertebral cage for use in repairing a damaged inter-vertebral disc includes a plurality of cage sections and a hinge element that connects adjacent ones of the cage sections together for...
9560849 Antibacterial surfactant/microgel formulations, methods of making and methods of using the same  
In a first broad aspect, described herein is an antimicrobial formulation comprised of: at least one nonionic surfactant capable of providing colloidal stability to the formulation, and at least...
US20170021343 Catalysts and Related Processes For Producing Optically Pure Beta-Lactones From Aldehydes and Compositions Produced Thereby  
Bi-functional cobalt-containing catalysts useful for making stereospecific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure β-lactones...
9549928 Muscarinic agonists as enhancers of cognitive flexibility  
Methods and compositions for treating a mental condition in a subject in need thereof, includes administering to a subject in need thereof an effective amount of a CDD-102A compound...
US20170014169 METHODS, DEVICES, AND MANUFACTURE OF THE DEVICES FOR MUSCULOSKELETAL RECONSTRUCTIVE SURGERY  
A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in...
9546196 Compositions and methods of treatment of cancers  
Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
US20170009265 Enhancement of Lignocellulose Saccharification Via A Low Temperature Ionic Liquid Pre-Treatment Scheme  
A method for pretreating lignocellulosic biomass having a lignin component, a hemicellulose component, and a cellulose component, for conversion to sugar is disclosed. Also disclosed is the...
9528161 Materials and methods for quality-controlled two-color RT-QPCR diagnostic testing of formalin fixed embedded and/or fresh-frozen samples  
Described herein are materials, methods, and kits enabling accurate and reproducible two-color reverse-transcription real-time quantitative PCR (RT-qPCR) for quality-controlled molecular...
9528104 System for simultaneous isomerization and fermentation of sugars  
Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single...
9527952 Amorphous polyester from bio-based bis-furan assembly  
Polymers, including Polyesters and Polycarbonates comprising residue of bis-furan diol, which is produced from renewable furfural feedstock and methods of making and using of those polyesters and...
9522068 Minimally invasive collapsible cage  
An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally...
US20160361255 Peptide Nanotubes for Slow Release of Drugs at Peripheral Nerve Injury  
Described herein are materials and methods useful for the treatment of neurodegenerative disorders in a subject. Materials described herein include polysaccharide digestive products resulting from...