Patents and Patent Applications from University of Toledo


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10077422 Microalgae harvesting using stimuli-sensitive hydrogels  
A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
US20180256177 Minimally Invasive Thrombectomy  
A minimally invasive blood clot capturing invention made of nitinol The nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The...
US20180250252 POTENT PHTHALATE INHIBITORS OF ASPARTATE N-ACETYLTRANSFERASE AND SELECTIVE ASPARTATE PATHWAY INHIBITORS  
Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or both, are described, as well as...
10064972 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Injectable, biodegradable bone cements and methods of making and using same
 
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed. A bone cement composition includes a powder comprising a basic source of calcium,...
10064798 Method for modulating pigmentation by targeting BET bromodomain proteins  
Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein...
10052403 Injectable, biodegradable bone cements and methods of making and using same  
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
10052402 Injectable, biodegradable bone cements and methods of making and using same  
Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
10043922 Back contact layer for photovoltaic cells  
A photovoltaic cell structure is disclosed that includes a back contact layer that includes single wall carbon nanotube elements. The single wall carbon nanotube (SWNT) back contact is in...
US20180219166 Inexpensive, Earth-Abundant, Tunable Hole Transport Material For CdTe Solar Cells  
Hole transport layers, electron transport layers, layer stacks, and optoelectronic devices involving perovskite materials and materials used as precursors, and methods of making the same, are...
US20180216163 METHODS FOR STANDARDIZED SEQUENCING OF NUCLEIC ACIDS AND USES THEREOF  
Methods for controlling for non-systematic error in an amplification-based next generation sequencing (NGS) library preparation are described, which method includes using an internal amplification...
10016394 PPARG modulators for treatment of osteoporosis  
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an...
10010078 Antibacterial surfactant/microgel formulations, methods of making and methods of using the same  
Formulations having, as active agents, at least one quaternized polymeric microgel and at least one nonionic surfactant, methods of making, and methods of using are described.
US20180127793 Methods for High Yield Production of Furans from Biomass Sugars at Mild Operating Conditions  
Facile methods for high-yield furfural and HMF production from biomass sugars are described. The methods generally involve converting the biomass sugars in high yield to their ketose isomers,...
9956008 Stabilized spinal fixation device  
A spinal fixation device includes a device body configured for implantation in a human body and a clamp that is formed from shape memory material and attached to the device body.
9944973 Methods for standardized sequencing of nucleic acids and uses thereof  
Methods for standardized sequencing of nucleic acids and uses thereof are described. The identification of genetic information is becoming a key piece of information for the diagnosis and...
US20180055942 Ionically Crosslinked Polyelectrolytes as Underwater Adhesives and Controlled Release Vehicles  
Underwater adhesive materials, methods of making the same, and methods of using the same are described.
9901460 Minimally invasive collapsible cage  
An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally...
US20180051214 High-Yield Production of Fuels and Petro- and Oleo-Chemical Precursors from Vegetable Oils and Other Liquid Feedstocks in a Continuous-Flow Pyrolysis Reactor With or Without Catalysts  
Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.
US20180028558 THERAPEUTIC POLYSACCHARIDE MIDI-GAGR AND RELATED MATERIALS AND METHODS  
Described herein are materials and methods useful for the treatment of neurodegenerative disorders as well as bone disorders in a subject. Materials described herein include polysaccharide...
US20180012002 ANALOGS OF PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) AGONISTS AND METHODS OF USING THE SAME  
Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing...
US20180009772 Highly Selective Anti-Cancer Agents Targeting Non-Small Cell Lung Cancer and Other Forms of Cancer  
Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal...
9862692 Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer  
Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal...
9856445 System for simultaneous isomerization and fermentation of sugars  
Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single...
9845294 Ring closing metathesis approach to produce precursors of nylon 11, 12, and 13 from oleic acid  
Provided herein is a method of producing C11, C12, and C13 nylon precursors from oleic acid or esters of oleic acid, the method involving amide formation, ring-closing metathesis, and...
9828615 Methods for high yield production of furans from biomass sugars at mild operating conditions  
Facile methods for high-yield furfural and HMF production from biomass sugars are described. The methods generally involve converting the biomass sugars in high yield to their ketose isomers,...
9821008 Inhibitors of ERCC1-XPF and methods of using the same  
Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to...
9814778 Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles  
Underwater adhesive materials, methods of making the same, and methods of using the same are described.
9809781 Thermal fractionation of biomass of non-lignocellulosic origin for multiple high-quality biofuels  
Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described. The products of said methods are also described.
9808299 Bioactive fusion device  
In a first broad aspect, there is provided herein a bioactive device and system for fusion between two bones, two parts of a bony joint, or a bony defect, such as of the spine. The fusion device...
US20170313972 High Yield Algal Biomass Production Without Concentrated CO2 Supply Under Open Pond Conditions  
Methods and systems for efficient culturing of algae in open ponds are described.
US20170311599 Target for Anthelmintic Development, and Anthelmintics Utilizing the Same  
Compounds, compositions, methods, materials, and transgenic animals for antihelmintic purposes are described.
9788541 Antibacterial surfactant/microgel formulations, methods of making and methods of using the same  
Formulations having, as active agents, at least one quaternized polymeric microgel and at least one surfactant, methods of making, and methods of using are described.
US20170292154 Methods For Determining Biological States By Assessing Amounts Of Target Nucleic Acids In A Sample  
Described herein are compositions for evaluating nucleic acids, standardized mixture for assessing amounts of at least one target nucleic acid in a sample, and kits comprising the same.
9782748 Synthesis of polymeric ionic liquids using a photochemical polymerization process  
Photo-initiated polymeric ionic liquids, methods of making and methods of using the same are disclosed. A preferred embodiment for making a photo-initiated polymeric ionic liquid (P-PIL) coated...
9782746 Polymeric ionic liquids, methods of making and methods of use thereof  
Polymeric ionic liquids, methods of making and methods of using the same are disclosed.
US20170283385 Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same  
Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing...
9765094 Ultrastable silver nanoparticles  
Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
US20170258369 LARYNGEAL MECHANOSENSOR STIMULATOR  
This invention is a device that provides feedback controlled pressure output that delivers a highly controlled and accurate air stimulus into the larynx for diagnostic use. The device is designed...
9750954 Concurrent delivery of interstitial thermobrachytherapy (hyperthermia and brachytherapy) in the treatment of cancer  
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
9743961 Bioactive fusion device  
A fusion device includes a screw having a head and a shaft. A hollow bone dowel is disposed about the shaft of the screw. The bone dowel is formed from a bone-like, biocompatible, or allograft...
US20170216623 Concurrent Delivery of Interstitial Thermobrachytherapy (Hyperthermia and Brachytherapy) in the Treatment Of Cancer  
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
9718052 Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby  
Bi-functional cobalt-containing catalysts useful for making stereospecific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure β-lactones...
US20170204051 Cross Metathesis Approach to C11-C13 Fatty-Chain Amino Esters From Oleic Acid Derivatives  
A concise method of producing nylon 11, 12, or 13 precursors from oleic acid or an ester of oleic acid is described. The method involves cross-metathesis reactions as the key C—C bond formation...
US20170196702 Apparatus and Method for Injecting Bone Graft Substitute and Other Materials  
A metering delivery apparatus for injecting bone graft cement includes a body portion, a material containment vessel, an actuator, and a control unit. The body portion includes a drive housing...
9695137 Analogs of peroxisome proliferator activated receptor (PPAR) agonists, and methods of using the same  
Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.
US20170173068 Wound Healing Agent Made From Low Acyl Gellan Gum, Methods of Making and Methods of Using the Same  
Described herein are materials and methods useful for the treatment of neurodegenerative disorders and bone disorders, as well as healing wounds, in a subject. Materials described herein include...
9683261 Standardized mixtures for assessing amounts of target nucleic acids in a sample, and kits therefore  
Described herein are compositions for evaluating nucleic acids, standardized mixture for assessing amounts of at least one target nucleic acid in a sample, and kits comprising the same.
9682246 System for concurrent delivery of thermobrachytherapy in the treatment of cancers  
A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.
9675717 Electromagnetic polymer composite material for anti-fouling effect  
The antifouling coating is a composite material consisting of fluorinated electroactive bipolymers and magnetic particles. This composite material is coated on a solid surface to make a smooth...
US20170158640 Ring Closing Metathesis Approach To Produce Precursors Of Nylon 11, 12, And 13 From Oleic Acid  
Provided herein is a method of producing C11, C12, and C13 nylon precursors from oleic acid or esters of oleic acid, the method involving amide formation, ring-closing metathesis, and...