Patents and Patent Applications from University of Tennessee


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US20180195186 Tunable Thin Liquid/Gas Diffusion Layers for Electrolyzers  
A liquid/gas diffusion layer (LGDL) 112 for use in a proton exchange membrane electrolyzer cell 100 includes a planar body 120 having first and second surfaces 128, 130 that are separated by a...
US20180194954 POROUS THERMALLY INSULATING COMPOSITIONS CONTAINING HOLLOW SPHERICAL NANOPARTICLES  
A method of thermally insulating a surface, the method comprising applying a coating of a thermally insulating composition onto said surface, wherein said thermally insulating composition...
10019470 Method and apparatus for constructing, using and reusing components and structures of an artifical neural network  
A method and apparatus for constructing a neuroscience-inspired artificial neural network (NIDA) or a dynamic adaptive neural network array (DANNA) or combinations of substructures thereof...
10017471 Selective androgen receptor degrader (SARD) ligands and methods of use thereof  
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions...
10017391 Direct polymer templating synthesis of mesoporous carbon  
The invention is directed to a method for fabricating a mesoporous carbon composite material. The method comprises providing a precursor composition and subjecting the precursor material to a...
US20180189460 LPA2 RECEPTOR-SPECIFIC BENZOIC ACID DERIVATIVES  
Disclosed is a five-feature pharmacophore model of LPA2 receptor specific agonists. Compounds may be identified as agonists of the LPA2 receptor using the five-feature pharmacophore model.
10010521 SARMs and method of use thereof  
This invention is directed to substituted acylanilide compounds and uses thereof in improving or preserving lung function and cardiac function in a subject suffering from Duchenne muscular dystrophy.
10010516 Method for regulating retinal endothelial cell viability  
Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be...
9999773 Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters  
Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially...
US20180155620 TERNARY METAL HALIDE SCINTILLATORS  
Metal halide scintillators are described. More particularly, the scintillators include Tl and/or In-based ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A is an...
9983162 Method and device for detection of bioavailable drug concentration  
The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible...
9981915 Compounds for treatment of cancer  
The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.
US20180136684 POWER SYSTEM DISTURBANCE LOCATION DETERMINATION BASED ON RATE OF CHANGE OF FREQUENCY  
A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; determining,...
US20180136267 MAGNETIC FIELD BASED WIRELESS GMD/EMP-E3 IMPACT MONITORING DEVICE  
A system and methods for monitoring an impact of geomagnetic disturbances (GMDs) or an E3 component of electromagnetic pulses (EMP-E3), involving a transducer generating a transduced signal in...
US20180126170 NEUROSTIMULATION AND RECORDING OF PHYSIOLOGICAL RESPONSE FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
US20180118901 METHOD OF PRODUCING CARBON FIBERS AND CARBON FIBER COMPOSITES FROM PLANT DERIVED LIGNIN AND ITS BLENDS  
Carbon fiber composites containing lignin carbon fibers are described. The lignin carbon fibers can be derived from organosolv lignin obtained from single source lignocellulosic feedstocks or...
US20180118693 COMPOUNDS FOR TREATMENT OF CANCER  
The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.
US20180118663 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF  
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate...
US20180117333 RESPONSIVE NEUROSTIMULATION FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
US20180116994 SARMS AND METHOD OF USE THEREOF  
This invention is directed to substituted acylanilide compounds and uses thereof in treating muscular dystrophies such as Duchenne muscular dystrophy and Becker muscular dystrophy and in improving...
9951398 Methods for gas-phase thermochromatographic separations of fission and activation products  
Methods are provided for characterizing samples containing chemical elements such as rare earth elements, actinides, and heavy transition metals by treating the samples to form volatile complexes...
9950169 Dynamic stimulation adjustment for identification of a neural fulcrum  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically...
US20180105745 TERNARY METAL HALIDE SCINTILLATORS  
Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A...
US20180102166 MEMORY CELL COMPRISING COUPLED JOSEPHSON JUNCTIONS  
Methods and apparatus are disclosed for operating a memory cell formed from the plurality of coupled Josephson junctions. The memory cell is configured such that applying an electrical signal to...
US20180097405 DUAL-FREQUENCY MODE TRANSMITTER FOR WIRELESS POWER TRANSFER  
A transmitter for wireless power transfer is provided. The transmitter includes an input port, a first transmission port, a second transmission port, an inverter, and a controller. An input of the...
US20180093971 COMPOUNDS FOR TREATMENT OF CANCER  
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a...
US20180092817 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING TOOTH EROSION  
An oral composition is provided comprising crosslinked polyvinylpyrrolidone (PVP) and xylitol. The xylitol and the crosslinked PVP are in a ratio of about 5:1, and the oral composition is in the...
US20180080103 ADDITIVE MANUFACTURING METHODS USING ALUMINUM-RARE EARTH ALLOYS AND PRODUCTS MADE USING SUCH METHODS  
Described herein are additive manufacturing methods and products made using such methods. The alloy compositions described herein are specifically selected for the additive manufacturing methods...
US20180080102 SURFACE-HARDENED ALUMINUM-RARE EARTH ALLOYS AND METHODS OF MAKING THE SAME  
Embodiments of surface-hardened aluminum-rare earth alloys and methods of making the alloys are disclosed. In some embodiments, the alloy comprises aluminum and 4 wt % to 60 wt % of a rare earth...
US20180071242 SUBSTITUTED ACYLANILIDES AND METHODS OF USE THEREOF  
This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or...
US20180042919 PARP Inhibitors for the Treatment of Major Depressive Disorder and Related Conditions  
Pharmaceutical formulations comprising an inhibitor of poly(ADP)-ribose) polymerase-1 (PARP1) and their use for the treatment of major depressive disorder and conditions that share at least one of...
9889110 Selective androgen receptor modulator for treating hormone-related conditions  
This invention provides use of a SARM compound or a composition comprising the same in treating and preventing muscle wasting in patients with non-small cell lung cancer (NSCLC); treating...
9884804 Surface treated carbon catalysts produced from waste tires for fatty acids to biofuel conversion  
A method of making solid acid catalysts includes the step of sulfonating waste tire pieces in a first sulfonation step. The sulfonated waste tire pieces are pyrolyzed to produce carbon composite...
9884038 Selective androgen receptor modulator and methods of use thereof  
This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia, a muscle wasting disease and/or...
9873094 Cross-linked polymeric membranes for carbon dioxide separation  
A membrane useful in gas separation, the membrane comprising a cross-linked polysiloxane structure having a cross-link density of about 0.1×10−5 mol/cm3 to about 6×10−5 mol/cm3, where, in...
US20180019483 REDOX FLOW BATTERY WITH INCREASED-SURFACE-AREA ELECTRODE AND ASYMMETRIC ELECTROLYTE CONCENTRATION  
A flow battery having stable electrochemical performance is provided. The flow battery includes a separator disposed between a positive electrode and a negative electrode, a first flow plate to...
US20180018358 METHOD AND APPARATUS FOR CONSTRUCTING A NEUROSCIENCE-INSPIRED ARTIFICIAL NEURAL NETWORK WITH VISUALIZATION OF NEURAL PATHWAYS  
A method and apparatus for constructing one of a neuroscience-inspired artificial neural network and a neural network array comprises one of a neuroscience-inspired dynamic architecture, a dynamic...
US20170370880 METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION IN A FLUID SAMPLE  
The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a...
US20170369900 SCN PLANTS AND METHODS FOR MAKING THE SAME  
The invention relates to genes which may be utilized for resistance to soybean cyst nematode. More specifically the present disclosure relates to identification of gene(s) that can confer upon a...
US20170368003 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF  
This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their...
US20170362719 BIOELECTROCHEMICAL BIOREFINING FOR THE CONVERSION OF HYDROGENOUS MATTER TO HYDROGEN GAS AND OTHER USEFUL PRODUCTS  
A method for the substantially complete conversion of hydrogenous matter to higher value product, the method comprising: (i) subjecting the hydrogenous matter to a substantially complete...
US20170360927 DIAGNOSING AND TREATING IGA NEPHROPATHY  
Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient...
US20170360875 METHODS FOR TREATING IMMUNE-MEDIATED VIRAL INFECTIONS  
Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated...
US20170360722 2-DODECYL-6-METHOXYCYCLOHEXA-2,5-DIENE-1,4-DIONE AS A CANCER THERAPEUTIC  
2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), as well as variants, derivatives, analogs, modifications, and conjugates thereof, are identified as therapeutic agents for treating or...
9844528 SARMs and method of use thereof  
This invention is directed to substituted acylanilide compounds and uses thereof in treating muscular dystrophies such as Duchenne muscular dystrophy and Becker muscular dystrophy and in improving...
9834525 Inhibitors of paxillin function and related compositions and methods  
This disclosure relates to small molecule inhibitors of paxillin and paxillin binding, and related compositions and methods of treatment.
9834507 Selective androgen receptor degrader (SARD) ligands and methods of use thereof  
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate...
US20170342014 SURFACE TREATED CARBON CATALYSTS PRODUCED FROM WASTE TIRES FOR FATTY ACIDS TO BIOFUEL CONVERSION  
A method of making solid acid catalysts includes the step of sulfonating waste tire pieces in a first sulfonation step. The sulfonated waste tire pieces are pyrolyzed to produce carbon composite...
US20170327906 METHODS FOR PREDICTING AND REDUCING RISK OF COPPER DEFICIENCY IN A RUMINANT SUBJECT OR A RUMINANT HERD  
A method for treating copper deficiency in a ruminant subject or a ruminant herd is dexcribed. In some embodiments, the method involves providing a sample from the subject or at least one subject...
US20170326530 SURFACE-FUNCTIONALIZED POLYOLEFIN FIBERS AND THEIR USE IN METHODS FOR EXTRACTING METAL IONS FROM LIQUID SOLUTIONS  
A fiber useful in the absorption of metal ions from aqueous solutions, the fiber comprising a polyolefin backbone having a diameter of at least 1 micron and having covalently appended on its...