Patents and Patent Applications from University of Tennessee


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9834525 Inhibitors of paxillin function and related compositions and methods  
This disclosure relates to small molecule inhibitors of paxillin and paxillin binding, and related compositions and methods of treatment.
9834507 Selective androgen receptor degrader (SARD) ligands and methods of use thereof  
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate...
US20170342014 SURFACE TREATED CARBON CATALYSTS PRODUCED FROM WASTE TIRES FOR FATTY ACIDS TO BIOFUEL CONVERSION  
A method of making solid acid catalysts includes the step of sulfonating waste tire pieces in a first sulfonation step. The sulfonated waste tire pieces are pyrolyzed to produce carbon composite...
US20170327906 METHODS FOR PREDICTING AND REDUCING RISK OF COPPER DEFICIENCY IN A RUMINANT SUBJECT OR A RUMINANT HERD  
A method for treating copper deficiency in a ruminant subject or a ruminant herd is dexcribed. In some embodiments, the method involves providing a sample from the subject or at least one subject...
US20170326530 SURFACE-FUNCTIONALIZED POLYOLEFIN FIBERS AND THEIR USE IN METHODS FOR EXTRACTING METAL IONS FROM LIQUID SOLUTIONS  
A fiber useful in the absorption of metal ions from aqueous solutions, the fiber comprising a polyolefin backbone having a diameter of at least 1 micron and having covalently appended on its...
US20170326098 CIS-GNETIN H AND TRANS-GNETIN H AS THERAPEUTIC AGENTS  
The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic...
9815776 Selective androgen receptor degrader (SARD) ligands and methods of use thereof  
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate...
9814698 Selective androgen receptor degrader (SARD) ligands and methods of use thereof  
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions...
US20170319854 NEUROSTIMULATION IN A NEURAL FULCRUM ZONE FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
US20170319444 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING TOOTH EROSION  
Methods and compositions are provided for reducing, treating or preventing dental erosion in a patient in need of such treatment, the methods and compositions comprising administering a...
9808626 Responsive neurostimulation for the treatment of chronic cardiac dysfunction  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
US20170312005 SYSTEM AND METHOD FOR HIGH FREQUENCY LEAKAGE REDUCTION THROUGH SELECTIVE HARMONIC ELIMINATION IN ELECTROSURGICAL GENERATORS  
An electrosurgical generator includes: a power supply configured to output a DC waveform; an inverter coupled to the power supply, the inverter including a plurality of switching elements; and a...
9798751 Method and apparatus for constructing a neuroscience-inspired artificial neural network  
A method and apparatus for constructing a neuroscience-inspired dynamic architecture (NIDA) for an artificial neural network is disclosed. The method comprises constructing, in one embodiment, an...
9796648 Glycerol dehydration methods and products thereof  
Methods and systems for suppressing coking in dehydration reactions catalyzed by solid acids. Dehydration reactions catalyzed by one or more solid acid catalysts can be performed in the presence...
US20170296997 COMPOSITIONS, SYSTEMS AND METHODS FOR PRODUCING NANOALLOYS AND/OR NANOCOMPOSITES USING TANDEM LASER ABLATION SYNTHESIS IN SOLUTION-GALVANIC REPLACEMENT REACTION  
Compositions, systems, and methods for producing nanoalloys and/or nanocomposites using tandem laser ablation synthesis in solution-galvanic replacement reaction (LASiS-GRR) are disclosed. The...
US20170296824 FINE RESOLUTION IDENTIFICATION OF A NEURAL FULCRUM FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
9789316 Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
US20170291139 CARBONATION OF METAL SILICATES FOR LONG-TERM CO2 SEQUESTRATION  
In a preferred embodiment, the invention relates to a process of sequestering carbon dioxide. The process comprises the steps of: (a) reacting a metal silicate with a caustic alkali-metal...
US20170290846 IN SITU GELLING FORM FOR LONG-ACTING DRUG DELIVERY  
The present invention relates to an injectable polymer matrix drug delivery system comprising a biodegradable polymer, a solvent or a combination of solvents, and an active pharmaceutical ingredient.
US20170281807 TARGETING IMMUNOTHERAPY FOR AMYLOIDOSIS  
Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to...
9774246 Three-phase current source rectifier for power supplies  
A three-phase current source rectifier (CSR) with three AC inputs may include a controller, a free-wheeling diode with a cathode connected to a positive line and an anode connected to a negative...
9773876 Semiconductor composition containing iron, dysprosium, and terbium  
An amorphous semiconductor composition includes 1 to 70 atomic percent iron, 15 to 65 atomic percent dysprosium, 15 to 35 atomic percent terbium, balance X, wherein X is at least one of an...
US20170268032 Assay for High-Throughput Identification of Therapeutic Compounds  
A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers...
US20170267722 INHIBITORY PEPTIDES OF VIRAL INFECTION  
Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed...
9768333 Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles  
The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to...
9753959 Method and apparatus for constructing a neuroscience-inspired artificial neural network with visualization of neural pathways  
A method and apparatus for constructing one of a neuroscience-inspired artificial neural network and a neural network array comprises one of a neuroscience-inspired dynamic architecture, a dynamic...
US20170247834 COMPREHENSIVE PROCESS FOR SELECTIVELY SEPARATING LIGNOCELLULOSIC BIOMASS INTO PURIFIED COMPONENTS WITH HIGH YIELD  
A comprehensive process for treating lignocellulosic biomass in order to separate the biomass into its component parts, the process comprising: a) contacting the lignocellulosic biomass with a...
9744108 Methods and compositions for preventing and treating tooth erosion  
Methods and compositions are provided for reducing, treating or preventing dental erosion in a patient in need of such treatment, the methods and compositions comprising administering a...
US20170240506 SELECTIVE ANDROGEN RECEPTOR MODULATOR AND METHODS OF USE THEREOF  
This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia, a muscle wasting disease and/or...
9730908 SARMs and method of use thereof  
This invention is directed to substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease...
9730898 Reversible, on-demand generation of aqueous two-phase microdroplets  
The present invention provides methods of on-demand, reversible generation of aqueous two-phase microdroplets core-shell microbeads, microparticle preparations comprising the core-shell...
US20170226086 COMPOUNDS FOR TREATMENT OF CANCER  
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma,...
US20170219719 RADIATION DETECTOR FOR IMAGING APPLICATIONS WITH STABILIZED LIGHT OUTPUT  
A radiation detection system may include a detector. The detector may include a scintillator to convert ionizing radiation, which originates externally to the detector, into visible light, a...
US20170218265 INTRINSIC AND ACTIVATED A4BX6 SCINTILLATORS  
Mixed halide scintillation materials of a first general formula A4B(1-y)MyX′6(1-z)X″6z and a second general formula A(4-y)BMyX′6(1-z)X″6z are disclosed. In the general formulas, A is an alkali...
9718693 Carbonation of metal silicates for long-term CO2 sequestration  
In a preferred embodiment, the invention relates to a process of sequestering carbon dioxide. The process comprises the steps of: (a) reacting a metal silicate with a caustic alkali-metal...
US20170209202 SYSTEM AND METHOD FOR HARMONIC CONTROL OF DUAL-OUTPUT GENERATORS  
A dual-output generator is configured to output two or more waveforms at different frequencies. In particular, the dual-output generator is configured to provide low-frequency output, which may be...
US20170208730 FLEX ROLLER-CRIMPER FOR IMPROVED MANAGEMENT AND TERMINATION OF COVER CROPS AND OTHER PLANT MATERIAL  
Herein is described an agricultural device that can include a frame; and a plurality of roller-crimping devices supported by the frame arranged in at least one row oriented in a direction that is...
9713719 Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction  
Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy...
9708434 Multigraft copolymers as superelastomers  
Thermoplastic elastomer compositions are described comprising multigraft copolymers. The multigraft copolymers can comprise a rubbery polymeric backbone and a plurality of glassy polymeric side...
US20170200457 TAMPERING DETECTION AND LOCATION IDENTIFICATION OF DIGITAL AUDIO RECORDINGS  
Systems and methods for detecting a tampering and identifying a location of a digital recording are provided. A frequency sequence and a phase angle sequence may be extracted from the digital...
9700246 Method and device for detection of bioavailable drug concentration in a fluid sample  
The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a...
US20170191029 METHODS FOR IMPROVEMENT OF SEMEN QUALITY  
A method for improving quality of a mammalian semen sample includes providing an insoluble carrier carrying at least one ligand that binds to an indicator of impaired sperm membrane integrity...
US20170190969 TERNARY METAL HALIDE SCINTILLATORS  
Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A...
9696304 Methods for detecting a biomarker by alternating current electrokinetics  
Methods are described for detecting pathogens, infectious diseases, and physiological conditions by quantifying change of impedance over time of when a biological sample is applied onto a...
9695356 Ternary metal halide scintillators  
Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A...
US20170186518 IRON NITRIDE MAGNETIC MATERIAL INCLUDING COATED NANOPARTICLES  
The disclosure describes techniques for forming nanoparticles including Fe16N2 phase. In some examples, the nanoparticles may be formed by first forming nanoparticles including iron, nitrogen, and...
US20170183440 MULTIGRAFT COPOLYMER SUPERELASTOMERS BY EMULSION POLYMERIZATION  
Multigraft copolymers having various structures, e.g., comb and centipede structures, can be prepared from emulsion copolymerization of monomers and macromonomers. The emulsion copolymerization...
9687220 Device for securing an object to a subject and wound closure  
Disclosed are devices, methods, and systems for securing an object to a subject, such as bandages and dressings over wounds, keeping wounds apposed, maintaining pressure on wounds, and stretching...
9683017 Inhibitory peptides of viral infection  
Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed...
US20170166526 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF  
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions...