Patents and Patent Applications from University of South Florida


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US20180051055 TOLL-LIKE RECEPTOR 2 LIGANDS AND METHODS OF MAKING AND USING THEREOF  
Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers,...
9896668 Substrate-mimetic AKT inhibitor  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3...
US20180045681 SYSTEM AND METHOD OF MEASURING CELL VIABILITY AND GROWTH  
A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as...
US20180042968 HUMAN CORD BLOOD AS A SOURCE OF NEURAL TISSUE REPAIR OF THE BRAIN AND SPINAL CORD  
The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the...
9893529 Coupling dynamics for power systems with iterative discrete decision making architectures  
Various examples are provided that are related to coupling dynamics for, e.g., power systems with iterative discrete decision making architectures. In one example, a method includes determining an...
9889221 Enhancement of photocatalytic effect with surface roughness in photocatalytic reactors  
Photocatalysis is a promising technique for remediation of indoor air pollution. The present invention focuses on the enhancement of the effectiveness of the photocatalytic process by the...
US20180037768 CUTIN-LIKE MATERIALS WITH ADVANCED FUNCTIONALITIES AND METHODS OF MANUFACTURE  
Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for...
US20180037529 Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases  
The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated...
US20180036529 SYSTEM AND METHOD FOR ELECTROPORATION CONTROLLED BY ELECTRICAL IMPEDANCE MEASUREMENTS  
The present invention provides a system and method for measuring the impedance of one more target cells before and after an electroporation protocol has been applied to the cells. The result of...
US20180036286 BIS-CYCLIC GUANIDINE COMPOUND COMPOSITIONS, METHODS OF USE AND TREATMENT THEREOF  
The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition...
US20180028488 TREATING AND/OR PREVENTING INSULIN-RESISTANCE RELATED WEIGHT GAIN  
Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).
US20180028145 ELECTRONIC CATHETER STETHOSCOPE  
An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in...
9879166 Encapsulation of thermal energy storage media  
In one embodiment, a method for fabricating a ceramic phase change material capsule includes forming a hollow ceramic capsule body having a filling hole, filling the ceramic capsule body with one...
9877739 Power morcellation in a protected environment  
A power morcellation system, apparatus, and methodology. Structurally, the device includes a sturdy, pliable (e.g., able to be inserted and retracted through a 10-15 mm morcellator port),...
9877668 Orientation invariant gait matching  
Aspects of gait matching are described herein. In one embodiment, a method of gait matching includes identifying a gait cycle timing in a data sequence captured by an inertial sensor, splitting...
US20180021456 SELF-ASSEMBLED TARGETED INCLUSION COMPLEXES FOR DRUG DELIVERY  
Inclusion complexes are provided containing a targeted carrier non-covalently associated with an active agent. The targeted carrier includes an inclusion host that binds the active agent or a...
9872849 Diterpenoid membranolide compounds having anti-leishmania activity and uses thereof  
In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania...
US20180016482 Encapsulation of Thermal Energy Storage Media  
In one embodiment, a method for depositing metal on a polymer surface, the method includes coating the polymer surface with a binding metal to render the polymer surface solvophillic and/or...
US20180016303 BK CHANNEL-MODULATING PEPTIDES AND THEIR USE  
The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca2+ activated K+ (BK) channel activity in cells; for treating...
US20180016171 SYSTEMS AND METHODS FOR TREATING DILUTE WASTEWATER  
In one embodiment, a dilute wastewater treatment system includes a separation subsystem configured to receive dilute wastewater and separate it into a product stream containing a low concentration...
US20180014866 BONE FUSION SYSTEM  
A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a...
9869038 Polypeptide electrospun nanofibrils of defined composition  
Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the...
9867915 Percutaneous endoscopic gastronomy tube for optimized gastric sumping  
An improved percutaneous endoscopic gastrostomy (PEG) tube that allows continuous suctioning/sumping without occlusion of the tube by the gastric wall. The PEG tube includes a hollow drainage...
US20180012748 SYSTEMS AND METHODS FOR BUBBLE BASED ION SOURCES  
The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, an ion channel, an electrode, and/or...
US20180008564 Method of Treating Colorectal Cancers Using a PKC Inhibitor  
The subject invention pertains to methods of treating colorectal cancer by administering an atypical PKC inhibitor. The inhibitors of aPKC useful in the methods of the instant invention include...
9863687 Self-heating apparatus and method of customizing a time-temperature profile thereof  
Self-heating apparatus and methodology for customizing a time-temperature profile thereof. The layered apparatus includes at least a layer of phase change material and a layer of air- or...
9861380 Minimally invasive laparoscopic tissue removal device  
A minimally invasive laparoscopic tissue removal device, namely a morcellator. The device includes, from proximal end to distal end, a handle, handle guard, elongate sheath, and mouth, finally...
US20180002706 METHODS AND COMPOSITIONS FOR CLONING INTO LARGE VECTORS  
Provided herein are methods of cloning into vectors.
US20180002413 INFLAMMATORY DISEASE DIAGNOSIS AND METHODS OF TREATMENT USING LIPOPOLYSACCHARIDE-RESPONSIVE BEIGE-LIKE ANCHOR  
Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine cascade is highly redundant and multiple...
US20180001298 METAL OXIDE-BASED BIOCOMPATIBLE HYBRID SORBENT FOR THE EXTRACTION AND ENRICHMENT OF CATECHOLAMINE NEUROTRANSMITTERS AND RELATED COMPOUNDS, AND METHOD OF SYNTHESIS  
The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO2 polypropylene oxide based sol-gel. The...
US20180000761 Methods for Making Catechin Derivatives  
Disclosed herein are methods for making a catechin derivative, or a salt thereof. The methods can include: contacting an alcohol protected aromatic aldehyde and a triphenyl phosphonium ylide to...
9859018 Physically unclonable function based on domain wall memory and method of use  
A system and method for providing a physically unclonable function (PFU) is described. In operation, the method includes applying a domain wall shift pulse challenge to a plurality of nanowires of...
US20170368142 METHODS OF TREATING COGNITIVE IMPAIRMENT  
The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one...
9848822 Prosthesis and orthosis slip detection sensor and method of use  
A device and method for measuring prosthetic or orthotic slip is presented. An optical sensor device is attached to the prosthesis or orthosis and measures the amount of relative motion between...
US20170362182 MULTIPLE-COMPONENT SOLID PHASES CONTAINING AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT  
The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component...
9846762 Gene signature for the prediction of radiation therapy response  
Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a...
9844519 Method of treating TDP-43 proteinopathies using hexachlorophene  
A method of treating TDP-43 proteinopathies such as Alzheimer's disease, amyotrophic lateral sclerosis, and fronto-temporal lobar dementia is presented herein. It was found that administering...
9840521 Organic anion lithium ionic cocrystal compounds and compositions  
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical...
9839718 Intracorporal ultra high purity calcium sulfate cast mixed with antimicrobials for the treatment of penile implant infections  
The present invention includes a method for treating penile implant infections that uses a synthetic high-purity calcium sulfate mixed with antimicrobials, which is capable of providing prolonged...
9839709 Compositions and methods for reducing or preventing medical device-related infections  
Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition...
US20170348336 METHOD OF TREATING MELANOMA USING AN INHIBITOR OF AN ATYPICAL PROTEIN KINASE C  
The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-ΞΆ and/or...
9836685 RFID tags for on- and off-metal applications  
In one embodiment, a radio-frequency identification (RFID) tag including a substrate having a top surface, bottom surface, opposed end surfaces, and opposed lateral surfaces, a passive RFID...
9831429 Method of manufacture for a partially-sprayed layer organic solar photovoltaic cell  
The fabrication and characterization of large scale inverted organic solar array fabricated using all-spray process is disclosed. Solar illumination has been demonstrated to improve transparent...
9828593 Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells  
Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain....
9827285 Compositions and methods of improving cognitive performance  
Provided herein are compositions, formulations, kits, and methods for improving or modifying cognitive performance in an individual having normal-age related cognitive decline. The composition can...
9826541 System and method for user-specific quality of service scheduling in wireless systems  
The present invention provides a novel rate adaptation algorithm and QoS-aware MAC scheduling system and method that either maximizes user satisfaction or maximizes spectrum utilization while...
9823188 Systems and methods for detecting the presence of a contaminant  
In some embodiments, a system for detecting the presence of a contaminant on a surface includes an infrared light source configured to shine infrared light on the surface, an infrared light...
9822359 Method of treating neurological disorders using long non-coding RNAs  
A method of treating traumatic brain injury (TBI) and other neurological disorders is presented herein. Both conditioned media (CM) containing long non-coding RNAs such as NEAT1 (nuclear enriched...
9820788 Bone fusion system  
A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a...
US20170328900 METHODS AND MATERIALS FOR CAPTURE ANTIBODY TARGETED FLUORESCENT IN-SITU HYBRIDIZATION (CAT-FISH)  
The subject invention concerns materials and methods for detecting a target cell in a population. Methods of the invention comprise internally labeling cells via fluorescence in situ hybridization...