Patents and Patent Applications from University of South Florida


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US20170044690 Polypeptide Electrospun Nanofibrils of Defined Composition  
Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the...
US20170044225 AMYLOID Precursor Protein (APP) Based β-Secretase Inhibitor Peptides, and Methods of Use  
The present invention provides fusion peptides, compositions, methods and kits for treating, reducing the risk of, lessening the severity of, preventing, or delaying the onset of amyloid-related...
US20170042927 EFFECTIVE TREATMENT OF OVARIAN CANCER USING TRICIRIBINE AND RELATED COMPOUNDS  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only...
9566011 Systems and methods for diagnosing cardiovascular conditions  
In one embodiment, a cardiovascular condition is diagnosed by recording a vectorcardiogram for a subject under evaluation, comparing the vectorcardiogram with vectorcardiograms of other subjects,...
US20170039892 SYNTHETIC VAGINAL CUFF MODEL AND METHOD OF SIMULATING VAGINAL CUFF CLOSURE  
A vaginal cuff surgical model and methods of manufacture and use thereof. The model includes a body (resembling a vaginal cuff) and appendages (resembling uterosacral ligaments) extending from the...
9556236 Compositions and methods for treating respiratory syncytial virus infection  
Briefly described, embodiments of the present disclosure relate to isolated polypeptides useful for treatment of respiratory syncytial virus, and to methods and compositions for treating...
9556131 Compositions, methods of use, and methods of treatment  
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition...
9555394 Method of making ionic liquid mediated sol-gel sorbents  
Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises...
9555392 Electrospun cactus mucilage nanofibers  
Novel electrospun nanofibers and nanofibrous membranes, methods of manufacturing the same, and methods of using the same are provided. The nanofibers include a cactus mucilage, such as mucilage...
US20170022540 BIOINK FOR THREE-DIMENSIONAL BIOMATERIAL PRINTING  
A method of creating “bioink” has been proposed, which increases the shelf-life and transportability of biological materials for use in bioprinting applications. The current invention also...
US20170020826 STABILIZATION OF ALCOHOL INTOXICATION-INDUCED CARDIOVASCULAR INSTABILITY  
The present invention concerns use of an agent that increases sphingosine-1-phosphate (S1P) receptor activity, such as S1P, or an S1P receptor agonist, for treatment of alcohol-intoxicated...
9550992 Compositions and methods for modulating myeloid derived suppressor cells  
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223...
US20170019284 JOINT PHYSICAL LAYER SECURITY AND PAPR MITIGATION IN OFDM SYTEMS  
Systems and methods for securing orthogonal frequency division multiplexing (OFDM) transmission of data are discussed herein. Transceivers can sense the signal strength of frequencies on an OFDM...
US20170018308 MTJ-BASED CONTENT ADDRESSABLE MEMORY  
Embodiments of the subject invention provide a three transistor, two domain-wall-based magnetic tunnel junction CAM cell (3T-2DW-MTJ CAM). A four transistor, two magnetic tunnel junction ternary...
9547940 Systems and methods for providing augmented reality in minimally invasive surgery  
In one embodiment, a method for providing augmented reality in minimally invasive surgery includes capturing pre-operative image data of internal organs of a patient, capturing intra-operative...
9547899 Mobile hemolysis detection in whole blood samples  
A system for hemolysis detection, where the system generally includes—individually or in combination—a containment apparatus for holding the blood sample and a software application for analyzing...
9543013 Magnetic tunnel junction ternary content addressable memory  
A Magnetic Tunnel Junction (MJT) Ternary Content Addressable Memory (TCAM) employing six transistors and exhibiting reduced standby leakage and improved area-efficiency. In the proposed TCAM, data...
9541112 Invisible picture hanging dot  
The present invention is an art hanging system that uses a drywall anchor combined with monofilament to create a nearly invisible ceiling hangar. The monofilament is fed through the low profile...
US20170004868 Robust Slope Detection Technique for STTRAM and MRAM Sensing  
Slope detection systems and methods are provided that monitor magnetic tunnel junction (MTJ) resistance switching. A low-overhead, sample-and-hold circuit can be used. Slope detection techniques...
US20170002317 CONVERSION OF NON-NEURONAL CELLS INTO NEURONS  
The subject invention concerns materials and methods for conversion of non-neuronal cells into neurons. The subject invention also concerns methods for screening drugs and other compounds for...
US20170000785 INHIBITORS OF THE FKBP51 PROTEIN FROM A HIGH-THROUGHPUT DRUG SCREEN AND METHODS OF USE  
The subject invention concerns materials and methods for treating depression, stress disorders, such as PTSD, anxiety disorders, and/or a neurodegenerative disease or condition in a person or...
US20170000754 KETONE SUPPLEMENTS FOR TREATMENT OF ANGELMAN SYNDROME  
The invention concerns a method of treating Angelman Syndrome (AS) in a subject, comprising inducing ketosis in the subject by administering a therapeutically effective amount of a ketone ester,...
US20170000630 Universal Multi-Branch Endograft  
The present invention provides endovascular stent graft conversion devices, systems and related methods that are particularly useful in aortic aneurysm repair, such as, but not limited to,...
US20170000612 OSTEOCONDUCTIVE AND OSTEOINDUCTIVE IMPLANT FOR AUGMENTATION, STABILIZATION, OR DEFECT RECONSTRUCTION  
Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the...
9533051 Menthol-based nanoparticles for drug delivery  
The subject invention pertains to formulations comprising poly(menthyl acrylate) nanoparticles comprising at least one active ingredient contained in a plurality of hydrophobic carriers and...
US20160375038 HORMONE TREATMENT FOR AGE-RELATED HEARING LOSS-PRESBYCUSIS  
Permanent hearing loss or deafness affects about 15% of people worldwide, about 40 million in the US alone. There are currently no FDA-approved drugs on the market in the US, or anywhere in the...
9531384 Adiabatic dynamic differential logic for differential power analysis resistant secure integrated circuits  
An adiabatic dynamic differential logic circuit is provided for mitigating a differential power analysis (DPA) attack on a secure integrated chip including a plurality of transistors configured to...
9531077 Flexible antenna and method of manufacture  
A flexible microwave antenna having a “fish-scale” ground plane is provided. The approach represents a significant advance in the combined thickness and flexibility that can be achieved,...
9528921 Materials and methods for capillary microextraction in combination with high-performance liquid chromatography comprising a sol-gel germania triblock polymer  
Germania-based sol-gel organic-inorganic hybrid coatings were prepared for on-line coupling of capillary microextraction with high-performance liquid chromatography. A germania-based sol-gel...
9526885 Microneedles with sharpened tips and corresponding method of fabrication  
Microneedles with sharpened tips are fabricated without any reduction to the shaft diameter below the tip. By sharpening the tip and not the entire length of the microneedle, their mechanical...
US20160369247 SUBSTRATE-MIMETIC AKT INHIBITOR  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3...
9522114 Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin  
Specific drug delivery to tumor cells without affecting normal cells is a major challenge in cancer treatment. The present invention incorporates embedding nonionic surfactant vesicles (niosomes)...
9520110 String vibration frequency altering shape  
The present invention is a novel variable tension string instrument that relies on a kinetic shape to actively alter the tension of a fixed length taut string. A mathematical model was derived...
9520072 Systems and methods for projecting images onto an object  
In one embodiment, a method for projecting images on a subject includes determining a pose and position of the subject, adjusting a three-dimensional model of an anatomical structure of the...
9518079 Effective treatment of tumors and cancer with triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination of (i) administering triciribine...
9517598 Method for making self-assembling, collagen-based material for corneal replacement  
A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into...
US20160354227 CUSTOM REDUCTION SPLINT FOR EDENTULOUS PATIENTS  
A custom oral splint that is operatively secured to the maxilla and mandible of a subject/patient to assist in reduction and provide maintenance of reduction of maxillary and mandibular fractures...
9515209 Bare quantum dots superlattice photonic devices  
Manipulation of the passivation ligands of colloidal quantum dots and use in QD electronics. A multi-step electrostatic process is described which creates bare QDs, followed by the formation of QD...
9514658 Synthetic skin and tissue model  
A synthetic tissue model using one or more semi-flexible polymers or resin with at least one embedded mesh material is provided herein. The model provides suitable simulation of animal tissue...
9513286 Differentially expressed genes in large granular lymphocyte leukemia  
The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL....
9512160 Antibacterial S-heterosubstituted disulfides  
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant...
9511348 Functionalized porous organic polymers for olefin/paraffin separations  
Compositions containing a porous organic polymer and a monovalent metal cation are provided for separation/purification of olefins and paraffins. The compositions can be stable and recyclable. The...
9511084 Compositions including triciribine and methods of use thereof  
This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates...
US20160351341 Microstructured Crystalline Device In Confined Space, A Dye-Sensitized Solar Cell, and Method of Preparation Thereof  
A method of forming an ordered nanorods array in a confined space is used to form a high surface area device where an ensemble of parallel trenches has micrometer dimensions for the width and...
9505623 One-step synthesis of graphene quantum dots  
Methods of making graphene quantums dots are provided. The methods can produce graphene quantum dots with a monodisperse size distribution. The graphene quantum dots are produced, via one-pot...
9504986 Metal-organic materials (MOMS) for polarizable gas adsorption and methods of using MOMS  
Embodiments of the present disclosure provide for multi-component metal-organic materials (MOMs) systems that exhibit permanent porosity and using MOMs to separate components in a gas mixture,...
9504440 Electronic catheter stethoscope  
An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in...
US20160340566 METHOD OF MODULATED EXOTHERMIC CHEMICAL SYSTEMS THROUGH PHASE CHANGE MATERIALS  
The chemical reactions modulation of temperature and dissipate heat through using phase change materials (PCM). Hydration of a mixture composed of encapsulated and/or non-encapsulated oxides such...
US20160339055 LITHIUM CO-CRYSTALS FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
The invention concerns methods and compositions for treating a neuropsychiatric disorder, wherein the method comprises administering an effective amount of a co-crystal of lithium to a subject in...
US20160338969 BIOCOMPATIBLE POLYACRYLATE COMPOSITIONS AND METHODS OF USE  
A biocompatible polymer material is described that exhibits mechanical and physical properties that are fundamental to many medical devices and treatment of many medical diseases and disorders....