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Patents and Patent Applications from University of South Florida


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9011446 Osteotome system  
A plurality of osteotomes that are linked together via a recess and a matching projection such that the osteotomes remain linked when used to manipulate bone.
US20150105328 PEPTOID-PEPTIDE HYBRIDS AND THEIR USE  
The invention concerns peptoid-peptide hybrids that may act as protein interaction inhibitors (PPIIs). Another aspect of the invention concerns a method for treating a disorder (e.g., an oncologic...
9007140 Digitally controlled wide range pulse width modulator  
The present invention provides a digitally controlled, current starved, pulse width modulator (PWM). In the PWM of the present invention, the amount of current from the voltage source to the ring...
9005890 Alloy nanoparticles for metal-enhanced luminescence  
Metal enhanced luminescence using alloy nanoparticles offers additional degrees of freedom for tuning their optical properties by altering atomic composition and atomic arrangement when compared...
8999326 Oncotherapeutic application of inhibitors of high-affinity glucose transporters  
The subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject...
8999283 Systems and methods for converting carbon dioxide into chemical feedstock  
In one embodiment, carbon dioxide is converted into a chemical feedstock by providing a mixture of plasmonic material and oxygen-conducting material, exposing the mixture to sunlight so that solar...
US20150094744 VASCULAR ANASTOMOSIS STENT  
Provided herein are devices, methods, and kits for a stent based anastomosis.
US20150093768 DETECTION OF PROSTATE AND BLADDER CANCER  
The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage prostate cancer and bladder cancer, in a subject by detecting Bcl-2 in...
8993760 Rock inhibitors and uses thereof  
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that...
US20150087044 POLYHEDRAL CAGE-CONTAINING MESOPOROUS METAL-ORGANIC FRAMEWORKS AS PLATFORM FOR BIOCATALYSIS, METHODS OF MAKING THESE FRAMEWORKS, AND METHODS OF USING THESE FRAMEWORKS  
Embodiments of the present disclosure provide compositions including polyhedral mesoporous metal-organic framework including a biomolecule (e.g., enzyme), methods of making these compositions,...
8987474 Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs  
Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and...
US20150080409 COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT  
Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of...
8980677 Transparent contacts organic solar panel by spray  
A method of fabricating organic solar panels with transparent contacts. The method uses a layer-by-layer spray technique to create the anode layer. The method includes placing the substrate on a...
US20150072029 MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES  
The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated...
US20150071918 PEPTIDES FOR THE TREATMENT OF CANCER  
The invention relates to novel cyclic compounds (cyclic peptides), linkers useful as beta-turn promoters in cyclic peptides, and methods for treatment of malignant cells in vitro or in vivo using...
8975372 Collagen scaffolds, medical implants with same and methods of use  
The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific...
US20150065995 INTRALUMINAL OCCLUDING CATHETER  
An intraluminal occluding catheter and method for preventing the loss of gas insufflation from a physiological lumen during a medical procedure is presented. The intraluminal occluding catheter is...
US20150064116 MULTILAYERED MAGNETIC MICELLE COMPOSITIONS AND METHODS FOR THEIR USE  
Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second...
8962243 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8960259 Variable screening  
In one embodiment, a variable screen includes a generally flat sheet having a front surface, a back surface, and a plurality of elongated slits that extend through the sheet from the front surface...
US20150051466 IMPLANTABLE BIOCOMPATIBLE SiC SENSORS  
In one embodiment, an implantable biosensor includes a sense antenna comprising a silicon carbide substrate and a radiating electrode formed on the substrate.
US20150051294 Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases  
The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated...
US20150051291 N,N'-DI-1 NAPHTHYLGUANIDINE HCL (NAGH) AND N,N'-DI-P-NITROPHENYLGUANIDINE HCL (NAD) TREATMENT FOR STROKE AT DELAYED TIMEPOINTS  
A composition and method of treating stroke by administration of a novel sigma agonist is presented. Twenty-four hours after MCAO, systemic administration of several novel sigma agonists...
8956340 Urethral catheter assembly with a guide wire  
A urethral catheter assembly utilizing a removable guide wire for navigating the catheter through a patient's urethral lumen during the insertion procedure. The guide wire being very flexible and...
US20150044240 P53 VACCINES FOR THE TREATMENT OF CANCERS  
The present invention relates to immunotherapy methods for treating hyperproliferative disease in humans, particularly to hyperproliferative disease that is refractory to therapy. More...
US20150035615 VERTICAL MICROCOAXIAL INTERCONNECTS  
In one embodiment, a vertical microcoaxial interconnect includes a dielectric substrate having a top side and a bottom side, an inner conductor extending through the substrate from its top side to...
US20150030609 DIAGNOSIS AND TREATMENT OF TRAUMATIC BRAIN INJURY  
The subject invention identifies CC chemokine ligand 20 (CCL20) as a novel biomarker for diagnosis of traumatic brain injury and/or neurodegeneration in the brain. The subject invention also...
US20150030585 COMPOSITIONS INCLUDING TRICIRIBINE AND ONE OR MORE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
8940945 Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases  
The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated...
8940159 Reduction and control of pH and soluble CO2 for optimal nitrification for domestic, industrial and municipal wastewater  
The invention includes a method for the optimization of the soluble CO2 concentration in the aeration basin of an activated sludge system, which significantly improves the specific growth rate of...
US20150024967 THREE-DIMENSIONAL FIBROUS SCAFFOLDS FOR CELL CULTURE  
Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a...
US20150018276 METHOD OF TREATMENT OF CANCER USING GUANOSINE 3', 5' CYCLIC MONOPHOSPHATE (CYCLIC GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as...
US20150017259 INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER  
Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically...
8927518 Method for the treatment of malignancies  
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently...
8927243 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
US20150004698 SUBSTRATE-MIMETIC AKT INHIBITOR  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3...
US20150004592 SAMPLE STORAGE FOR MOLECULAR AND IMMUNOLOGICAL DETECTION  
A method for the direct molecular analysis of nucleic acid or antibodies from a natural or synthetic solid matrix for storing, preserving, and transporting nucleic acid or antibodies samples and...
8924536 Distributed and decentralized location aware architecture  
Provided is a distributed and decentralized location-aware system. The system includes a number of peers, each in communication with other peers and adapted to communicate PING, PONG, and ALERT...
8923773 Minimally invasive networked surgical system and method  
A system for performing non-invasive networked medical procedures including a number of in vivo medical devices, a communication path between at least two of the devices, an ex vivo control unit...
8922452 Periodic spiral antennas  
In one embodiment, a periodic spiral antenna includes first and second arms that form interleaved spirals parallel to an x-y plane, wherein the arms have a height dimension that extends along a z...
8922272 System and method for voltage regulator-gating  
A system and method for adaptive activity management of on-chip voltage regulators based upon the workload information is provided to force each on-chip regulator to operate in its most...
8921312 Combination of insulin and ascorbate to enhance wound healing  
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without...
8920700 Telescopic nanotube device for hot nanolithography  
A device for maintaining a constant tip-surface distance for producing nanolithography patterns on a surface using a telescopic nanotube for hot nanolithography. An outer nanotube is attached to...
8920426 Apparatus for osteotomy and graft preparation  
Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side...
US20140378516 COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT  
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition...
8916698 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8916343 DNA biochip and methods of use  
The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized...
US20140371208 METHODS OF TREATING DISEASE-INDUCED ATAXIA AND NON-ATAXIC IMBALANCE  
Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.
US20140370510 MODULATION OF PEPTIDOME USING HISTONE DEACETYLASE INHIBITOR  
Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the...
US20140369983 ISCHEMIC TISSUE CELL THERAPY  
The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the...