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Patents and Patent Applications from University of South Florida


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8802647 Materials and methods for prevention and treatment of RNA viral diseases  
The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient....
8802643 Method for the treatment of malignancies  
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently...
8802638 Flavonoid treatment of glycogen synthase kinase-based disease  
The flavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes pr...
US20140221658 INHIBITION OF CELL PROLIFERATION  
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly...
US20140221473 Compositions, Methods of Use, and Methods of Treatment  
Embodiments of the present disclosure provide compositions including ketamine analogues, salts, and disalts, pharmaceutical compositions including ketamine analogues, salts, or disalts, methods of...
8796235 Methods for attenuating dengue virus infection  
The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression...
8795498 Microbial cell and particle selection system and method of use  
The invention comprises two key components: dielectrophoresis (DEP) and reversible binding surfaces. DEP has become an important tool for trapping dielectric particles. Moreover, DEP can manipulate...
8793849 Method of manufacturing high frequency thickness shear mode gas and organic vapor sensors  
A method of fabricating a thickness shear mode (TSM) gas and organic vapor sensor having a visco-elastic polymer coating and a fundamental frequency greater than 20 MHz. The method begins by...
US20140213802 (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome  
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
US20140213604 PROTEIN KINASE C AS A TARGET FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS  
The subject invention concerns a method of inhibiting respiratory syncytial virus (RSV) infection in a patient by decreasing the endogenous protein kinase C (PKC) activity within the patient....
US20140209564 Method for the Fabrication of Electrolyte Cavities Using Surface Micromachining  
The present invention is directed to the fabrication of thin aluminum anode batteries using a highly reproducible process that enables high volume manufacturing of the galvanic cells. A method of...
US20140205570 RECOMBINANT ADENO-ASSOCIATED VIRUS-MEDIATED EXPRESSION OF FRACTALKINE FOR TREATMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE DISEASES  
The subject invention pertains to the use of fractalkine (FKN, CX3CL1) and its receptor CX3CR1 for treatment of neuroinflammation and/or neurodegeneration. In one embodiment, the present invention...
8788015 Method of rapidly visualizing essential neural pathways  
A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and...
8785176 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8784832 Synthetic antigen based on the ligand domain of the Plasmodium vivax duffy binding protein  
The disclosure provides compositions that are useful for eliciting a strain-transcending immune response in an animal or human directed against the blood-stage of the malarial parasite Plasmodium...
8784802 Ischemic tissue cell therapy  
The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present...
8783242 Charcoal grill having re-chargeable charcoal feed for continuous operation  
A charcoal grill includes a base for holding charcoal, support legs, and a lid mounted to the base. A metal band, having an opening formed therein, encircles the base. A box is secured to the metal...
US20140197355 METHOD OF ENCAPSULATING A PHASE CHANGE MATERIAL WITH A METAL OXIDE  
Storage systems based on latent heat storage have high-energy storage density, which reduces the footprint of the system and the cost. However, phase change materials (PCMs), such as NaNO3, NaCl,...
8778986 Treatment of glycogen synthase kinase-based disease  
The bioflavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes pr...
8778894 Luteolin and diosmin/diosmetin as novel STAT3 inhibitors for treating autism  
The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form,...
8778680 Stable differentiation of NT2 cells  
A method of differentiating adult stem cells, such as those derived from a teratocarcinoma cell line, the Ntera2/D1 clone (NT2). The developed cells exhibit a stable neurotransmitter phenotype...
US20140194834 Auto-Regulation System for Intraocular Pressure  
A device and system for controlling pressure via fluid exchange in the body is presented. The device and system may be used to control intraocular eye pressure. The system is comprised of four main...
US20140194719 Long-Term Implantable Silicon Carbide Neural Interface Device Using the Electrical Field Effect  
Field effect devices, such as capacitors and field effect transistors, are used to interact with neurons. Cubic silicon carbide is biocompatible with the neuronal environment and has the chemical...
US20140194495 CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION  
The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts...
US20140190898 Cactus Mucilage and Ferric Ions for the Removal of Arsenate (As(V)) from Water  
Potable drinking water is plagued with widespread arsenic contamination, particularly in developing communities. Ferric ions were introduced to interact with arsenate based on the strong affinity...
8770664 Reclining chair with two positions of repose  
A reclining chair having two stable positions of repose: an upright position and a reclined position. The chair having two peripheral supports and multiple intermediate supports disposed between...
US20140186316 METHODS AND COMPOSITIONS FOR TREATMENT OF TRAUMATIC BRAIN INJURY AND FOR MODULATION OF MIGRATION OF NEUROGENIC CELLS  
Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain....
8765119 Treating amyotrophic lateral sclerosis (ALS)with isolated aldehyde dehydrogenase-positive umbilical cord blood cells  
A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase...
US20140179979 THERAPEUTIC AGENT APPLICATORS AND METHODS OF USING THE SAME  
The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic...
D707613 Wiper blade ornament  
D707612 Wiper blade ornament  
D707611 Wiper blade ornament  
8759662 Bulk dimensional nanocomposites for thermoelectric applications  
Thermoelectric elements may be used for heat sensors, heat pumps, and thermoelectric generators. A quantum-dot or nano-scale grain size polycrystalline material the effects of size-quantization are...
8759479 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8759317 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as sma...
US20140171921 URETHRAL CATHETER ASSEMBLY WITH A GUIDE WIRE  
A urethral catheter assembly utilizing a removable guide wire for navigating the catheter through a patient's urethral lumen during the insertion procedure. The guide wire being very flexible and...
US20140170225 IMMUNOTHERAPY FOR TREATMENT OF AMYLOID-RELATED DISORDERS USING ENCAPSULATED BETA-AMYLOID PEPTIDES  
The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.
D707173 Wiper blade ornament  
US20140162989 MULTIPLE-COMPONENT SOLID PHASES CONTAINING AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT  
The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to binary phase...
US20140162891 METHODS AND MATERIALS FOR DETECTION, DIAGNOSIS AND MANAGEMENT OF OVARIAN CANCER  
The subject invention concerns methods using a panel of proteins to detect, diagnose, and monitor therapy during treatment of ovarian cancer in a female patient. The proteins were identified using...
8751162 System for pattern recognition in real-time location-based services applications  
A prediction method that estimates the real-time position of a mobile device based on previously observed data is provided. The present invention can be used in real-time navigation, including...
8751015 Graphene electrodes on a planar cubic silicon carbide (3C-SiC) long term implantable neuronal prosthetic device  
Graphene, can be used to make an implantable neuronal prosthetic which can be indefinitely implanted in vivo. Graphene electrodes are placed on a 3C—SiC shank and electrical insulation is p...
8748172 Cell modeling of heme deficiency using ferrochelatase mutations  
Provided herein, is a means for development of ferrochelatase variants with improved tolerance towards N-methyl protoporphyrin. Also disclosed are cell assay systems utilizing the variants, as the...
8738125 Devices and methods for delivering molecules to the heart with electric fields  
A device and related methodologies to deliver molecules to the cells that comprise any tissues. The invention includes a catheter-based electrode and methods for its use for the delivery of...
8737908 Interactive book and spatial accountability method  
The current invention promotes accountability in reading, in terms of spatial, causal, temporal, protagonist, and intentionality elements of a story. A book with interactive maps was developed to...
8736835 Dual-gas microcavity Raman sensor and method of use  
In accordance with the present invention, a dual-gas Raman sensor is provided that is based on an enhanced spontaneous dual emission as a result of cavity quantum electrodynamic effects. The...
8735090 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8735073 Cannabinoid 2 (CB2) receptor gene promoter and unique RNA transcripts in B cells and methods of use  
Cannabinoid receptor 2 (CB2) is expressed in B lymphocytes and is involved in immune regulation. Mouse splenic B cells express three CB2 transcripts utilizing two different first exons. Human...
8734521 Asymmetric disc distracting cage  
An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement...
US20140142057 EFFECTIVE TREATMENT OF OVARIAN CANCER USING TRICIRIBINE AND RELATED COMPOUNDS  
The inventors have determined, contrary to the prior art aid experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to...