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Patents and Patent Applications from University of South Florida


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8962243 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8960259 Variable screening  
In one embodiment, a variable screen includes a generally flat sheet having a front surface, a back surface, and a plurality of elongated slits that extend through the sheet from the front surface...
US20150051466 IMPLANTABLE BIOCOMPATIBLE SiC SENSORS  
In one embodiment, an implantable biosensor includes a sense antenna comprising a silicon carbide substrate and a radiating electrode formed on the substrate.
US20150051294 Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases  
The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated...
US20150051291 N,N'-DI-1 NAPHTHYLGUANIDINE HCL (NAGH) AND N,N'-DI-P-NITROPHENYLGUANIDINE HCL (NAD) TREATMENT FOR STROKE AT DELAYED TIMEPOINTS  
A composition and method of treating stroke by administration of a novel sigma agonist is presented. Twenty-four hours after MCAO, systemic administration of several novel sigma agonists...
8956340 Urethral catheter assembly with a guide wire  
A urethral catheter assembly utilizing a removable guide wire for navigating the catheter through a patient's urethral lumen during the insertion procedure. The guide wire being very flexible and...
US20150044240 P53 VACCINES FOR THE TREATMENT OF CANCERS  
The present invention relates to immunotherapy methods for treating hyperproliferative disease in humans, particularly to hyperproliferative disease that is refractory to therapy. More...
US20150035615 VERTICAL MICROCOAXIAL INTERCONNECTS  
In one embodiment, a vertical microcoaxial interconnect includes a dielectric substrate having a top side and a bottom side, an inner conductor extending through the substrate from its top side to...
US20150030609 DIAGNOSIS AND TREATMENT OF TRAUMATIC BRAIN INJURY  
The subject invention identifies CC chemokine ligand 20 (CCL20) as a novel biomarker for diagnosis of traumatic brain injury and/or neurodegeneration in the brain. The subject invention also...
US20150030585 COMPOSITIONS INCLUDING TRICIRIBINE AND ONE OR MORE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
8940945 Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases  
The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated...
8940159 Reduction and control of pH and soluble CO2 for optimal nitrification for domestic, industrial and municipal wastewater  
The invention includes a method for the optimization of the soluble CO2 concentration in the aeration basin of an activated sludge system, which significantly improves the specific growth rate of...
US20150024967 THREE-DIMENSIONAL FIBROUS SCAFFOLDS FOR CELL CULTURE  
Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a...
US20150018276 METHOD OF TREATMENT OF CANCER USING GUANOSINE 3', 5' CYCLIC MONOPHOSPHATE (CYCLIC GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as...
US20150017259 INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER  
Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically...
8927518 Method for the treatment of malignancies  
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently...
8927243 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
US20150004698 SUBSTRATE-MIMETIC AKT INHIBITOR  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3...
US20150004592 SAMPLE STORAGE FOR MOLECULAR AND IMMUNOLOGICAL DETECTION  
A method for the direct molecular analysis of nucleic acid or antibodies from a natural or synthetic solid matrix for storing, preserving, and transporting nucleic acid or antibodies samples and...
8924536 Distributed and decentralized location aware architecture  
Provided is a distributed and decentralized location-aware system. The system includes a number of peers, each in communication with other peers and adapted to communicate PING, PONG, and ALERT...
8923773 Minimally invasive networked surgical system and method  
A system for performing non-invasive networked medical procedures including a number of in vivo medical devices, a communication path between at least two of the devices, an ex vivo control unit...
8922452 Periodic spiral antennas  
In one embodiment, a periodic spiral antenna includes first and second arms that form interleaved spirals parallel to an x-y plane, wherein the arms have a height dimension that extends along a z...
8922272 System and method for voltage regulator-gating  
A system and method for adaptive activity management of on-chip voltage regulators based upon the workload information is provided to force each on-chip regulator to operate in its most...
8921312 Combination of insulin and ascorbate to enhance wound healing  
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without...
8920700 Telescopic nanotube device for hot nanolithography  
A device for maintaining a constant tip-surface distance for producing nanolithography patterns on a surface using a telescopic nanotube for hot nanolithography. An outer nanotube is attached to...
8920426 Apparatus for osteotomy and graft preparation  
Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side...
US20140378516 COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT  
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition...
8916698 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8916343 DNA biochip and methods of use  
The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized...
US20140371208 METHODS OF TREATING DISEASE-INDUCED ATAXIA AND NON-ATAXIC IMBALANCE  
Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.
US20140370510 MODULATION OF PEPTIDOME USING HISTONE DEACETYLASE INHIBITOR  
Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the...
US20140369983 ISCHEMIC TISSUE CELL THERAPY  
The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the...
US20140367258 SYSTEM AND METHOD FOR ELECTROWETTING ACTUATION UTILIZING DIODES  
An electrowetting system and method for the movement of a droplet across the surface of a substrate, utilizing an applied voltage. The actuation of the droplet is achieved by introducing a diode...
8914102 Method and device for anesthesiology measurement and control  
Cell or tissue permeability to electrical signals can be used to determine the depth of anesthesia of a patient. A method and device is presented to measure, record and control the effects of...
8912006 Microfluidic device for generating neural cells to simulate post-stroke conditions  
This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and...
D719071 Omnidirectional mobility device  
8908796 Orthogonal frequency division multiplexing (OFDM) transmitter and receiver windowing for adjacent channel interference (ACI) suppression and rejection  
An optimum time domain windowing scheme for orthogonal frequency-division multiplexing (OFDM)-based waveforms in the sense of spectral concentration is proposed. Instead of evenly suppressing the...
8908089 Implantable imaging device  
An imaging device for in vivo medical applications that enables minimally invasive surgical procedures. The imaging device includes an elongated frame having a base, a module housing, and an...
8906918 Compositions, methods of use, and methods of treatment  
Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of...
8906869 Effective treatment of ovarian cancer using triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only...
8906414 Methods and compositions for improving bioavailability of epigallocatechin gallate (EGCG)  
Compositions and methods of increasing the bioavailability of catechins are presented. Compositions for increasing the bioavailability of catechins include compositions where the catechin is added...
8906052 Method and device for the treatment of hypertrophic cardiomyopathy  
A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device...
US20140356955 FERROMAGNETIC CELL AND TISSUE CULTURE MICROCARRIERS  
A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also...
8901086 Compositions including triciribine and methods of use thereof  
This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates...
US20140350105 COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS  
Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of...
US20140350052 Methods and Compositions for Reducing Serum Levels of Immunoglobulin E (IGE)  
The present disclosure provides methods and pharmaceutical compositions for reducing the serum level of immunoglobulin IgE in an animal or human subject. It has been found that reducing or...
8895248 Method for detecting Salmonella species by assaying outer membrane Porin F (ompF)  
The invention relates to a method of detecting the presence of Salmonella in a sample using novel oligonucleotide sequences. Also presented is a kit for putting the method into practice and novel...
US20140343120 METHODS AND COMPOSITIONS FOR REDUCING ACTIVITY OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR AND FOR TREATMENT OF DISEASES  
Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of...
8891430 Edge windowing of OFDM based systems  
Various methods and systems are provided for edge windowing of orthogonal frequency division multiplexing (OFDM) systems. In one example, among others, a method includes obtaining an edge...
US20140336945 GENE SIGNATURE FOR THE PREDICTION OF RADIATION THERAPY RESPONSE  
Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a...