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Patents and Patent Applications from University of South Florida


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8715365 Injectable hip hemiarthroplasty  
The invention discloses a surgical technique and apparatus for minimally invasive replacement of a fractured femoral head in hip arthroscopy. The fractured femoral head is first removed from the...
8710248 (−)-epigallocatechin gallate derivatives for inhibiting proteasome  
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
8709635 Aluminum galvanic cell  
The present invention provides a galvanic cell having an aluminum anode and a cathode compartment design suitable for carrying out the aqueous electrochemical reaction between solid aluminum metal...
8703963 Derivative N-thiolated 2-oxazolidinone antibiotics  
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by...
US20140107333 POLYHEDRAL CAGE-CONTAINING METALLOPORPHYRIN FRAMEWORKS, METHODS OF MAKING, AND METHODS OF USING  
Embodiments of the present disclosure provide compositions including metal-organic polyhedrons, metalloporphyrin framework structures, methods of making these, methods of using these, and the like.
US20140103247 Magneto-Dielectric Polymer Nanocomposites and Method of Making  
In accordance with the present invention, novel superparamagnetic magneto-dielectric polymer nanocomposites are synthesized using a novel process. The tunability of the dielectric/magnetic...
8697437 Magnetic metabolite and diagnostic transfer disks  
A magnetic, selectively permeable metabolite transfer disk for the cell-free transfer of metabolites and other molecules produced by microbial colonies is described. The metabolite transfer disk is...
8697095 Inhibition of replication of oncogenic herpesviruses  
A method of treating gamma oncogenic herpesviruses, in vivo, through use of Delta-9 Tetrahydrocannabinol (THC). THC inhibits KSHV and EBV reactivation as well as inhibiting lytic replication of MHV...
US20140099286 CELL THERAPY FOR CHRONIC STROKE  
A method of treating stroke in a patient who has undergone a stroke comprising administering at least 2 million suitable neuronal cells in at least one brain area involved in the stroke. The method...
8691799 Materials and methods for treatment of cancer and identification of anti-cancer compounds  
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular...
8691779 Compositions including triciribine and taxanes and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer,...
8691571 Extending tissue preservation  
A method of sustaining cells is provided. The method can include providing a non-perfluorocarbon cell storage medium, providing a pre-oxygenated liquid perfluorocarbon in contact with the storage...
US20140094467 METHOD AND COMPOSITION FOR MODULATING CANONICAL WNT PATHWAY USING FOLATE AND INOSITOL  
The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure...
US20140093944 POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
US20140093933 MICROBIAL CELL AND PARTICLE SELECTION SYSTEM AND METHOD OF USE  
The invention comprises two key components: dielectrophoresis (DEP) and reversible binding surfaces. DEP has become an important tool for trapping dielectric particles. Moreover, DEP can manipulate...
8685240 High efficiency sol-gel gas chromatography column  
A capillary column (10) includes a tube structure having inner walls (14) and a sol-gel substrate (16) coated on a portion of inner walls (14) to form a stationary phase coating (18) on inner walls...
US20140087467 FERROMAGNETIC CELL AND TISSUE CULTURE MICROCARRIERS  
A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also provided...
US20140087447 Cell Modeling of Heme Deficiency using Ferrochelatase Mutations  
Provided herein, is a means for development of ferrochelatase variants with improved tolerance towards N-methyl protoporphyrin. Also disclosed are cell assay systems utilizing the variants, as the...
US20140087440 MAGNETIC THREE-DIMENSIONAL CELL CULTURE APPARATUS AND METHOD  
A culture apparatus and method for growing cells and tissue in a three-dimensional configuration harnesses magnetic, paramagnetic, ferromagnetic and diamagnetic forces. The cells or tissue are...
US20140082932 Method for the Fabrication of Electrolyte Cavities Using Bulk Micro-Machining  
The present invention is directed to the fabrication of thin aluminum anode batteries using a highly reproducible process that enables high volume manufacturing of the galvanic cells. A method of...
8682623 Electric power distribution interruption risk assessment calculator  
A method for predicting electrical power distribution interruptions based on common, immediate weather conditions. Daily, hourly, and bi-hourly weather data are used to predict the number of...
US20140080885 METHODS OF TREATING TRAUMATIC BRAIN INJURY  
Embodiments of the present disclosure provide methods of treating a traumatic brain injury with an agent. In particular, embodiments of the present disclosure provide for methods of treating a...
US20140080762 HYD1 PEPTIDES FOR RELAPSED CANCER  
The subject invention pertains to compositions and methods for treatment of malignancies and inhibiting the growth of cancer cells, such as multiple myeloma and other hematologic malignancies,...
8673910 Proteasome inhibitors for selectively inducing apoptosis in cancer cells  
The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical...
8673868 Compositions including triciribine and one or more platinum compounds and methods of use thereof  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
8673867 Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof  
This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions...
US20140074135 SMALL DIAMETER LAPAROSCOPIC TOOL HAVING RELEASABLE TIP  
A laparoscopy tool includes a sheath and a control wire slideably disposed within a lumen of the sheath. The sheath has a diameter of less than 1.6 mm and is introduced through an abdominal...
US20140073704 COLLAGEN SCAFFOLDS, MEDICAL IMPLANTS WITH SAME AND METHODS OF USE  
The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific...
US20140073693 USE OF KETONE ESTERS FOR PREVENTION OF CNS OXYGEN TOXICITY  
The present invention demonstrates the therapeutic use of ketone esters for seizure disorders, Alzheimer's disease and malignant brain cancer, which are associated with metabolic dysregulation. The...
US20140072654 CANCER WITH METABOLIC THERAPY AND HYPERBARIC OXYGEN  
The present invention demonstrates the therapeutic use of ketone esters for seizure disorders, Alzheimer's disease malignant brain cancer, and other cancers, which are associated with metabolic...
US20140071446 Dual-Gas Microcavity Raman Sensor and Method of Use  
In accordance with the present invention, a dual-gas Raman sensor is provided that is based on an enhanced spontaneous dual emission as a result of cavity quantum electrodynamic effects. The...
US20140069296 ANTI-FOULING BIO-HYDROGEL COMPOSITION  
The invention comprises a biological hydrogel that is chemically stabilized with non-covalent or covalent cross-links. The biological hydrogel is used to coat surfaces of materials for submersion...
8669376 Cytotoxin compounds and methods of isolation  
The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts...
8668905 P53 vaccines for the treatment of cancers  
The present invention relates to immunotherapy methods for treating hyperproliferative disease in humans, particularly to hyperproliferative disease that is refractory to therapy. More...
US20140067023 OPTICAL NEURON STIMULATION PROSTHETIC USING SILICON CARBIDE  
The microfabricated prosthetic device uses local, direct, and wavelength-specific optical stimulation to achieve an action potential from a single or small group of neurons within the central...
US20140065208 PROSTATE CARCINOGENESIS PREDICTOR  
A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or...
US20140065133 JAK/STAT INHIBITORS AND MAPK/ERK INHIBITORS FOR RSV INFECTION  
The present invention concerns a method for treating or reducing the likelihood of developing a respiratory syncytial virus (RSV) infection in a subject by administering an effective amount of an...
8666139 Method and apparatus for pulmonary ventilation imaging using local volume changes  
The invention provides a novel method of high-resolution quantifiable pulmonary regional ventilation imaging using a package of computer programs, including deformable image registration and local...
8662245 Frequency response treatment of wood paneling  
Disclosed is a method for modifying the frequency response of a wood panel within an acoustical structure such as a studio or concert hall. The modification is imparted by exciting the wood...
US20140057249 JAK/STAT INHIBITORS AND MAPK/ERK INHIBITORS FOR RSV INFECTION  
The present invention concerns a method for treating or reducing the likelihood of developing a respiratory syncytial virus (RSV) infection in a subject by administering an effective amount of an...
US20140057048 METHOD OF MAKING IONIC LIQUID MEDIATED SOL-GEL SORBENTS  
Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises...
US20140056931 GENETIC ADJUVANTS FOR IMMUNOTHERAPY  
The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of...
8660801 Gene signature for the prediction of radiation therapy response  
Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a...
8655598 Predictive radiosensitivity network model  
This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an...
US20140045888 COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY  
Compounds of formula I: or formula II: or a pharmaceutically acceptable salt of formula I or formula II, wherein:R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl;R2 is methyl...
US20140044690 High-Energy Compounds for Use in Alzheimer's and Other Neurodegenerative Diseases  
A method of treating or preventing a neurodegenerative disease includes administering an effective amount of a compound to a subject in need thereof. The compound includes a high-energy compound,...
US20140042038 MICROFLUIDIC ELECTROCHEMICAL GENOTYPING SYSTEM  
The present invention provides an electrochemical devices and methods for detecting, measuring or monitoring gene expression by detecting hybridization of nucleic acids to arrays. A support wafer...
US20140040402 SYSTEM AND METHOD FOR PREVENTING UNWANTED ELECTRONIC COMMUNICATIONS  
An email system, configured by creating a user controlled email domain for each user, rather than a dedicated email address. The user is then allowed to create unlimited email addresses within the...
US20140039381 MULTICHANNEL TROCAR  
A multi-channel trocar developed for use in minimal-access surgery/single incision laparoscopic surgery. The trocar permits surgical access of two or more articulating laparoscopic instruments or...
US20140038913 LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM  
The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form,...