Patents and Patent Applications from University of South Florida


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9872849 Diterpenoid membranolide compounds having anti-leishmania activity and uses thereof  
In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania...
US20180016482 Encapsulation of Thermal Energy Storage Media  
In one embodiment, a method for depositing metal on a polymer surface, the method includes coating the polymer surface with a binding metal to render the polymer surface solvophillic and/or...
US20180016303 BK CHANNEL-MODULATING PEPTIDES AND THEIR USE  
The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca2+ activated K+ (BK) channel activity in cells; for treating...
US20180016171 SYSTEMS AND METHODS FOR TREATING DILUTE WASTEWATER  
In one embodiment, a dilute wastewater treatment system includes a separation subsystem configured to receive dilute wastewater and separate it into a product stream containing a low concentration...
US20180014866 BONE FUSION SYSTEM  
A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a...
9869038 Polypeptide electrospun nanofibrils of defined composition  
Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the...
9867915 Percutaneous endoscopic gastronomy tube for optimized gastric sumping  
An improved percutaneous endoscopic gastrostomy (PEG) tube that allows continuous suctioning/sumping without occlusion of the tube by the gastric wall. The PEG tube includes a hollow drainage...
US20180012748 SYSTEMS AND METHODS FOR BUBBLE BASED ION SOURCES  
The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, an ion channel, an electrode, and/or...
US20180008564 Method of Treating Colorectal Cancers Using a PKC Inhibitor  
The subject invention pertains to methods of treating colorectal cancer by administering an atypical PKC inhibitor. The inhibitors of aPKC useful in the methods of the instant invention include...
9863687 Self-heating apparatus and method of customizing a time-temperature profile thereof  
Self-heating apparatus and methodology for customizing a time-temperature profile thereof. The layered apparatus includes at least a layer of phase change material and a layer of air- or...
9861380 Minimally invasive laparoscopic tissue removal device  
A minimally invasive laparoscopic tissue removal device, namely a morcellator. The device includes, from proximal end to distal end, a handle, handle guard, elongate sheath, and mouth, finally...
US20180002706 METHODS AND COMPOSITIONS FOR CLONING INTO LARGE VECTORS  
Provided herein are methods of cloning into vectors.
US20180002413 INFLAMMATORY DISEASE DIAGNOSIS AND METHODS OF TREATMENT USING LIPOPOLYSACCHARIDE-RESPONSIVE BEIGE-LIKE ANCHOR  
Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine cascade is highly redundant and multiple...
US20180001298 METAL OXIDE-BASED BIOCOMPATIBLE HYBRID SORBENT FOR THE EXTRACTION AND ENRICHMENT OF CATECHOLAMINE NEUROTRANSMITTERS AND RELATED COMPOUNDS, AND METHOD OF SYNTHESIS  
The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO2 polypropylene oxide based sol-gel. The...
US20180000761 Methods for Making Catechin Derivatives  
Disclosed herein are methods for making a catechin derivative, or a salt thereof. The methods can include: contacting an alcohol protected aromatic aldehyde and a triphenyl phosphonium ylide to...
9859018 Physically unclonable function based on domain wall memory and method of use  
A system and method for providing a physically unclonable function (PFU) is described. In operation, the method includes applying a domain wall shift pulse challenge to a plurality of nanowires of...
US20170368142 METHODS OF TREATING COGNITIVE IMPAIRMENT  
The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one...
9848822 Prosthesis and orthosis slip detection sensor and method of use  
A device and method for measuring prosthetic or orthotic slip is presented. An optical sensor device is attached to the prosthesis or orthosis and measures the amount of relative motion between...
US20170362182 MULTIPLE-COMPONENT SOLID PHASES CONTAINING AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT  
The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component...
9846762 Gene signature for the prediction of radiation therapy response  
Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a...
9844519 Method of treating TDP-43 proteinopathies using hexachlorophene  
A method of treating TDP-43 proteinopathies such as Alzheimer's disease, amyotrophic lateral sclerosis, and fronto-temporal lobar dementia is presented herein. It was found that administering...
9840521 Organic anion lithium ionic cocrystal compounds and compositions  
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical...
9839718 Intracorporal ultra high purity calcium sulfate cast mixed with antimicrobials for the treatment of penile implant infections  
The present invention includes a method for treating penile implant infections that uses a synthetic high-purity calcium sulfate mixed with antimicrobials, which is capable of providing prolonged...
9839709 Compositions and methods for reducing or preventing medical device-related infections  
Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition...
US20170348336 METHOD OF TREATING MELANOMA USING AN INHIBITOR OF AN ATYPICAL PROTEIN KINASE C  
The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-ζ and/or...
9836685 RFID tags for on- and off-metal applications  
In one embodiment, a radio-frequency identification (RFID) tag including a substrate having a top surface, bottom surface, opposed end surfaces, and opposed lateral surfaces, a passive RFID...
9831429 Method of manufacture for a partially-sprayed layer organic solar photovoltaic cell  
The fabrication and characterization of large scale inverted organic solar array fabricated using all-spray process is disclosed. Solar illumination has been demonstrated to improve transparent...
9828593 Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells  
Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain....
9827285 Compositions and methods of improving cognitive performance  
Provided herein are compositions, formulations, kits, and methods for improving or modifying cognitive performance in an individual having normal-age related cognitive decline. The composition can...
9826541 System and method for user-specific quality of service scheduling in wireless systems  
The present invention provides a novel rate adaptation algorithm and QoS-aware MAC scheduling system and method that either maximizes user satisfaction or maximizes spectrum utilization while...
9823188 Systems and methods for detecting the presence of a contaminant  
In some embodiments, a system for detecting the presence of a contaminant on a surface includes an infrared light source configured to shine infrared light on the surface, an infrared light...
9822359 Method of treating neurological disorders using long non-coding RNAs  
A method of treating traumatic brain injury (TBI) and other neurological disorders is presented herein. Both conditioned media (CM) containing long non-coding RNAs such as NEAT1 (nuclear enriched...
9820788 Bone fusion system  
A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a...
US20170328900 METHODS AND MATERIALS FOR CAPTURE ANTIBODY TARGETED FLUORESCENT IN-SITU HYBRIDIZATION (CAT-FISH)  
The subject invention concerns materials and methods for detecting a target cell in a population. Methods of the invention comprise internally labeling cells via fluorescence in situ hybridization...
9818466 Robust slope detection technique for STTRAM and MRAM sensing  
Slope detection systems and methods are provided that monitor magnetic tunnel junction (MTJ) resistance switching. A low-overhead, sample-and-hold circuit can be used. Slope detection techniques...
9815702 Systems and methods for converting carbon dioxide into chemical feedstock  
Provided herein are systems containing a solar reactor having a mixture of plasmonic material and oxygen-conducting material that can convert carbon dioxide into a chemical feedstock.
US20170321277 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND MANAGEMENT OF DIABETES AND METABOLIC SYNDROME  
Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods,...
9812954 Secure converter-gating, reconfiguration, and regulation  
Dynamic power management techniques and voltage converter architectures are described to provide a secure and efficient on-chip power delivery system. In aspects of the embodiments,...
9812312 Systems and methods for bubble based ion sources  
The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, a heat source positioned above the...
9812205 MTJ-based content addressable memory with measured resistance across matchlines  
Embodiments of the subject invention provide a three transistor, two domain-wall-based magnetic tunnel junction CAM cell (3T-2DW-MTJ CAM). A four transistor, two magnetic tunnel junction ternary...
9808513 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as...
9808448 Pharmaceutical compounds and use of same in cancer and tauopathies  
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or...
US20170316070 AUTOMATIC GENERATION OF STRUCTURED DATA FROM SEMI-STRUCTURED DATA  
A method and system for generating structured data from semi-structured data are provided. The method includes reading a plurality of records from a data file including semi-structured data....
9804491 Systems and methods for forming contact definitions  
In one embodiment, a mask set for use in fabricating thin film tunneling devices includes a first photomask configured to form bottom electrodes of the devices, the first photomask comprising a...
9801903 Targeting cancer with metabolic therapy and hyperbaric oxygen  
A method of treating cancer using ketogenic diet, while concurrently subjecting the patient to a hyperbaric, oxygen-enriched environment. Optionally, the hyperbaric, oxygen-enriched environment is...
9801865 Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation  
The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of Aβ peptide in neural tissue. The subject invention also concerns...
US20170304223 METHOD OF TREATING PROSTATE CANCER USING A PKC INHIBITOR  
The invention relates to compositions comprising a PKC inhibitor and their use in a method of treating or preventing the development of prostate cancer.
9795652 Use of endogenous antioxidant proteins in the treatment of stroke  
Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced...
9795637 Human cord blood as a source of neural tissue repair of the brain and spinal cord  
The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the...
9795584 Treating an atypical protein kinase C enzyme abnormality  
Provided herein are compounds, compositions, pharmaceutical formulations, methods of treating and methods of using aPKC inhibitors for treating and/or preventing of aPKC abnormalities.