Patents and Patent Applications from University of South Florida


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9289421 Methods and compositions for reducing serum levels of immunoglobulin E (IgE)  
The present disclosure provides methods and pharmaceutical compositions for reducing the serum level of immunoglobulin IgE in an animal or human subject. It has been found that reducing or...
9286687 System and method for estimating the magnetization states of a nanomagnet array  
A system and method for image-processing that will facilitate automatically analyzing and estimating atomic force microscopy (AFM) images and magnetic force microscopy (MFM) images of fabricated...
US20160068503 (-)-EPIGALLOCATECHIN GALLATE DERIVATIVES FOR INHIBITING PROTEASOME  
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
US20160067207 COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS  
Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of...
9277912 Systems and methods for ankle syndesmosis fixation  
In one embodiment, a fixation system includes an anchor adapted to be implanted within a first bone, a washer adapted to be associated with a second bone that is to be secured to the first bone,...
9276556 Micromechanical devices based on piezoelectric resonators  
In some embodiments, a micromechanical filter includes multiple subfilters, each subfilter comprising multiple piezoelectric resonators mechanically coupled in series, wherein the subfilters are...
9273762 Four-linkage backpack relocator  
A device to help an individual with a disability carry his or her bag or storage unit on their wheelchair or other mobility device, without requiring a large space to deploy the storage and...
US20160053319 MICRO-RNAS MODULATING IMMUNITY AND INFLAMMATION  
MicroRNAs are shown to be up- and/or down-regulated in inflammation and immune cells using a mouse model of asthma and regulatory T cells as source of RNA, respectively. Modulating the expression...
US20160052941 ORGANIC ANION LITHIUM IONIC COCRYSTAL COMPOUNDS AND COMPOSITIONS  
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical...
9267822 Systems and methods for evaluating coupled components  
In some embodiments, a system for evaluating coupled components includes a first diffraction grating provided on a first component, a second diffraction grating provided on a second component, a...
9265783 Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof  
This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions...
9265685 Compliant bimanual rehabilitation device and method of use thereof  
A compliant bimanual rehabilitation system. The device allows for the user or operator's hands to be coupled with a variety of coupling stiffnesses and in a variety of symmetry modes, leading to...
9263803 Mechanically reconfigurable antennas  
In some embodiments, a mechanically reconfigurable antenna includes a patch antenna, one or more parasitic patches, and a radially foldable linkage associated with the patch antenna that can be...
9260271 Knot tying devices  
In some embodiments, a knot tying device includes a body that defines a wheel slot and inner passages that lead to the wheel slot and a wheel that fits and can be rotated within the wheel slot,...
US20160043314 METHOD OF MANUFACTURING INVERTED ORGANIC SOLAR MICROARRAY FOR APPLICATIONS IN MICROELECTROMECHANICAL SYSTEMS  
The fabrication and characterization of large scale inverted organic solar array fabricated using all-spray process is disclosed. Solar illumination has been demonstrated to improve transparent...
US20160030483 MATERIALS AND METHODS FOR TREATING ALLERGIC AND INFLAMMATORY CONDITIONS  
The subject invention provides for the utilization of bone-marrow derived stem cells in the treatment of allergic and inflammatory diseases. In one embodiment, the invention provides for treatment...
US20160030388 DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF  
In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania...
9248035 Flared vaginal stent  
A flared vaginal stent having a body portion and an outwardly flared head portion as well as a method of use thereof is presented. The head portion is comprised of an outwardly flared tip,...
US20160022304 SMALL DIAMETER LAPAROSCOPIC TOOL HAVING RELEASABLE TIP  
A laparoscopy tool includes a sheath and a control wire slideably disposed within a lumen of the sheath. The sheath has a diameter of less than 1.6 mm and is introduced through an abdominal...
9241975 Reelin rescues congnitive function  
Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is...
9241851 Hands-free user interface devices  
In one embodiment, a hands-free user interface device includes a first plate, a second plate spaced from the first plate, a sensor associated with the plates adapted to detect when the first plate...
US20160015286 INTEGRATED VECTORCARDIOGRAM SYSTEM AND METHOD OF USE  
An integrated vectorcardiogram (VCG) device having 3 pairs of electrodes placed in three orthogonal directions with the capability to continuously measure the electrical activity of the heart. All...
9238149 Prevention and treatment of alzheimer'S disease through electromagnetic field exposure  
The invention includes a method of treating and preventing a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field emitting...
US20160013410 MASK-STACK-SHIFT METHOD TO FABRICATE ORGANIC SOLAR ARRAY BY SPRAY  
An all-spray fabrication method for large scale inverted organic solar array is provided. Zinc oxide sol gel solutions and revised layers shorten the fabrication process from 2 days to 5 hours and...
9234007 RGD mimetic γ-AApeptides and methods of use  
Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds,...
US20160003825 USE OF PKC-ZETA AS A BREAST CANCER TUMORIGENIC BIOMARKER AS WELL AS A TARGET FOR TREATMENT OF BREAST CANCER  
The present invention provides use of protein kinase C-zeta (PKC-ζ) as a diagnostic biomarker for breast cancer tumorigenesis. Also provided are uses of PKC-zeta inhibitors for inhibiting breast...
US20160002702 BLUE COLLAGENASE ASSAY  
A method of measuring soluble or insoluble cell or tissue-associated collagenase activity. The substrate includes native (fibrillar) collagen fragments that were stained with Coomassie Brilliant...
US20160001051 METHOD OF DRUG DELIVERY FOR OVARIAN CANCER  
A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular...
US20160000818 COMPOSITIONS INCLUDING TRICIRIBINE AND ONE OR MORE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
US20160000770 PHARMACEUTICAL COMPOUNDS AND USE OF SAME IN CANCER AND TAUOPATHIES  
Disclosed are compounds of formula (1)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or...
9226776 Apparatus for occipital-cervical fixation enabling supplemental occipital bone fixation  
An apparatus for stabilization of a patient's head relative to the patient's neck joint includes an occi-cervical base member having a “C”-shaped central part and first and second attachment rods...
US20150374474 SACROCOLPOPEXY/SACROCERVICOPEXY VAGINAL POSITIONING AND MESH RETENTION SYSTEM  
A vaginal support device, vaginal positioning system and associated method of treating pelvic prolapse is presented herein. Vaginal support device contains flat superior and inferior surfaces to...
US20150368599 DESIGN AND HOT EMBOSSING OF MACRO AND MICRO FEATURES WITH HIGH RESOLUTION MICROSCOPY ACCESS  
This disclosure provides micro-feature devices and methods for fabricating micro-feature devices. A micro-feature device can include a substantially rigid transparent substrate. The device can...
US20150367114 METHOD OF DILATING GASTROINTESTINAL STRICTURES USING A TRANS-ENDOSCOPIC HYDRAULIC BALLOON APPARATUS  
A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid...
US20150366883 METHOD OF TREATING OVARIAN CANCER USING A PKC INHIBITOR  
A method of treating ovarian cancer by administering a PKC inhibitor is presented herein. It was found that administering a PKC inhibitor, such as ACPD or ICA-1, to ovarian cancer cells inhibited...
US20150361110 SUPER LEWIS ACIDIC BORATE ESTERS AS 18F-LABELED PET PROBES  
Compounds having a 1-bora-1-fluoro-2,6,7-trioxabicyclo[2.2.2]octane moiety wherein the fluorine is 18F are described. Also described are reagents for radiolabeling a molecule having Formula I....
US20150359813 EFFECTIVE TREATMENT OF ESOPHOGEAL ADENOCARCINOMA USING TRICIRIBINE AND RELATED COMPOUNDS  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering...
US20150359240 CYTOKINE, CHEMOKINE AND GROWTH FACTORS IN DONOR HUMAN MILK  
Donor milk has become a standard of care for feeding preterm infants, particularly those with gestational ages of 34 weeks or less, whose mothers are not lactating or not producing sufficient milk...
9211401 Cubic silicon carbide implantable neural prosthetic  
An implantable neuronal prosthetic and method of manufacture thereof includes at least one elongated electrode shank adapted for arrangement in the brain having at least one electrode contact...
9211299 Compositions including triciribine and one or more platinum compounds and methods of use thereof  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
US20150357569 ORGANIC PHOTOVOLTAIC ARRAY AND METHOD OF MANUFACTURE  
The fabrication and characterization of large scale inverted organic solar array fabricated using all-spray process is disclosed, consisting of four layers; ITO-Cs2CO3-(P3HT:PCBM)-modified...
9206131 Compounds having antiparasitic or anti-infectious activity  
Compounds of formula I: or formula II: or a pharmaceutically acceptable salt of formula I or formula II, wherein:R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl;R2 is...
9206103 Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases  
The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated...
US20150335342 MINIMALLY INVASIVE LAPAROSCOPIC TISSUE REMOVAL DEVICE  
A minimally invasive laparoscopic tissue removal device, namely a morcellator. The device includes, from proximal end to distal end, a handle, handle guard, elongate sheath, and mouth, finally...
9195796 Malignancy-risk signature from histologically normal breast tissue  
The invention provides for malignancy-risk gene signatures that predict the risk of developing breast cancer, the recurrence of breast cancer, and/or the metastasis of breast cancer. These...
9192645 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the...
9192505 Custom reduction splint for edentulous patients  
A custom oral splint that is operatively secured to the maxilla and mandible of a subject/patient to assist in reduction and provide maintenance of reduction of maxillary and mandibular fractures...
US20150332501 ANALYSIS-SUITABLE GEOMETRY FROM DISCRETE POINT SETS USING A MESH-FREE METHOD  
The present invention includes a method of creating analysis suitable models from discrete point sets. The proposed methodology is completely automated, requiring no human intervention, as...
US20150327547 N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS  
The present invention provides N-alkylthio β-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and...
US20150327523 TRANSGENIC MOUSE MODEL FOR CONDITIONAL FKBP51 EXPRESSION AND RELATED METHODS  
The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding...