Patents and Patent Applications from University of South Florida


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9238149 Prevention and treatment of alzheimer'S disease through electromagnetic field exposure  
The invention includes a method of treating and preventing a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field emitting...
US20160013410 MASK-STACK-SHIFT METHOD TO FABRICATE ORGANIC SOLAR ARRAY BY SPRAY  
An all-spray fabrication method for large scale inverted organic solar array is provided. Zinc oxide sol gel solutions and revised layers shorten the fabrication process from 2 days to 5 hours and...
9234007 RGD mimetic γ-AApeptides and methods of use  
Embodiments of the present disclosure provide for RGD mimetic γ-AApeptide compounds, γ-AApeptide compounds capable of binding an RGD binding site on integrin αvβ3, linear γ-AApeptide compounds,...
US20160003825 USE OF PKC-ZETA AS A BREAST CANCER TUMORIGENIC BIOMARKER AS WELL AS A TARGET FOR TREATMENT OF BREAST CANCER  
The present invention provides use of protein kinase C-zeta (PKC-ζ) as a diagnostic biomarker for breast cancer tumorigenesis. Also provided are uses of PKC-zeta inhibitors for inhibiting breast...
US20160002702 BLUE COLLAGENASE ASSAY  
A method of measuring soluble or insoluble cell or tissue-associated collagenase activity. The substrate includes native (fibrillar) collagen fragments that were stained with Coomassie Brilliant...
US20160001051 METHOD OF DRUG DELIVERY FOR OVARIAN CANCER  
A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular...
US20160000818 COMPOSITIONS INCLUDING TRICIRIBINE AND ONE OR MORE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
US20160000770 PHARMACEUTICAL COMPOUNDS AND USE OF SAME IN CANCER AND TAUOPATHIES  
Disclosed are compounds of formula (1)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or...
9226776 Apparatus for occipital-cervical fixation enabling supplemental occipital bone fixation  
An apparatus for stabilization of a patient's head relative to the patient's neck joint includes an occi-cervical base member having a “C”-shaped central part and first and second attachment rods...
US20150374474 SACROCOLPOPEXY/SACROCERVICOPEXY VAGINAL POSITIONING AND MESH RETENTION SYSTEM  
A vaginal support device, vaginal positioning system and associated method of treating pelvic prolapse is presented herein. Vaginal support device contains flat superior and inferior surfaces to...
US20150368599 DESIGN AND HOT EMBOSSING OF MACRO AND MICRO FEATURES WITH HIGH RESOLUTION MICROSCOPY ACCESS  
This disclosure provides micro-feature devices and methods for fabricating micro-feature devices. A micro-feature device can include a substantially rigid transparent substrate. The device can...
US20150367114 METHOD OF DILATING GASTROINTESTINAL STRICTURES USING A TRANS-ENDOSCOPIC HYDRAULIC BALLOON APPARATUS  
A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid...
US20150366883 METHOD OF TREATING OVARIAN CANCER USING A PKC INHIBITOR  
A method of treating ovarian cancer by administering a PKC inhibitor is presented herein. It was found that administering a PKC inhibitor, such as ACPD or ICA-1, to ovarian cancer cells inhibited...
US20150361110 SUPER LEWIS ACIDIC BORATE ESTERS AS 18F-LABELED PET PROBES  
Compounds having a 1-bora-1-fluoro-2,6,7-trioxabicyclo[2.2.2]octane moiety wherein the fluorine is 18F are described. Also described are reagents for radiolabeling a molecule having Formula I....
US20150359813 EFFECTIVE TREATMENT OF ESOPHOGEAL ADENOCARCINOMA USING TRICIRIBINE AND RELATED COMPOUNDS  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering...
US20150359240 CYTOKINE, CHEMOKINE AND GROWTH FACTORS IN DONOR HUMAN MILK  
Donor milk has become a standard of care for feeding preterm infants, particularly those with gestational ages of 34 weeks or less, whose mothers are not lactating or not producing sufficient milk...
9211401 Cubic silicon carbide implantable neural prosthetic  
An implantable neuronal prosthetic and method of manufacture thereof includes at least one elongated electrode shank adapted for arrangement in the brain having at least one electrode contact...
9211299 Compositions including triciribine and one or more platinum compounds and methods of use thereof  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
US20150357569 ORGANIC PHOTOVOLTAIC ARRAY AND METHOD OF MANUFACTURE  
The fabrication and characterization of large scale inverted organic solar array fabricated using all-spray process is disclosed, consisting of four layers; ITO-Cs2CO3-(P3HT:PCBM)-modified...
9206131 Compounds having antiparasitic or anti-infectious activity  
Compounds of formula I: or formula II: or a pharmaceutically acceptable salt of formula I or formula II, wherein:R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl;R2 is...
9206103 Materials and methods for reduction of protein tau and treatment of neurodegenerative diseases  
The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated...
US20150335342 MINIMALLY INVASIVE LAPAROSCOPIC TISSUE REMOVAL DEVICE  
A minimally invasive laparoscopic tissue removal device, namely a morcellator. The device includes, from proximal end to distal end, a handle, handle guard, elongate sheath, and mouth, finally...
9195796 Malignancy-risk signature from histologically normal breast tissue  
The invention provides for malignancy-risk gene signatures that predict the risk of developing breast cancer, the recurrence of breast cancer, and/or the metastasis of breast cancer. These...
9192645 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the...
9192505 Custom reduction splint for edentulous patients  
A custom oral splint that is operatively secured to the maxilla and mandible of a subject/patient to assist in reduction and provide maintenance of reduction of maxillary and mandibular fractures...
US20150332501 ANALYSIS-SUITABLE GEOMETRY FROM DISCRETE POINT SETS USING A MESH-FREE METHOD  
The present invention includes a method of creating analysis suitable models from discrete point sets. The proposed methodology is completely automated, requiring no human intervention, as...
US20150327547 N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS  
The present invention provides N-alkylthio β-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and...
US20150327523 TRANSGENIC MOUSE MODEL FOR CONDITIONAL FKBP51 EXPRESSION AND RELATED METHODS  
The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding...
9186403 Compositions including triciribine and trastuzumab and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and...
9186167 Small diameter laparoscopic tool having releasable tip  
A laparoscopy tool includes a sheath and a control wire slideably disposed within a lumen of the sheath. The sheath has a diameter of less than 1.6 mm and is introduced through an abdominal...
US20150320784 EFFECTIVE TREATMENT OF TUMORS AND CANCER WITH TRICIRIBINE AND RELATED COMPOUNDS  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination of (i) administering triciribine...
9184308 Devices having nanoscale structures and methods for making same  
In one embodiment, devices, such as metal-insulator-metal tunneling diodes, are fabricated by forming a cavity in a substrate having a top surface, conformally depositing a thin film of material...
9182591 System and method for electrowetting actuation utilizing diodes  
An electrowetting system and method for the movement of a droplet across the surface of a substrate, utilizing an applied voltage. The actuation of the droplet is achieved by introducing a diode...
9180191 Treatment of suicidal ideation or behavior using inhibitors of nicotinic acetylcholine receptors  
The invention concerns methods of treating suicidal ideation or behavior in a subject in need thereof, comprising decreasing endogenous nicotinic acetylcholine receptor (nAChR) activity in the...
9179841 Adaptive optics ophthalmic imager without wavefront sensor or wavefront corrector  
The invention utilizes a digital holographic adaptive optics (DHAO) system to replace hardware components in a conventional AO system with numerical processing for wavefront measurement and...
9178261 Vertical microcoaxial interconnects  
In one embodiment, a vertical microcoaxial interconnect includes a dielectric substrate having a top side and a bottom side, an inner conductor extending through the substrate from its top side to...
9176122 Biomarkers for predicting response to immunosuppressive therapy  
The subject invention concerns methods and materials for assessing a patient's likelihood of responsiveness to an immunosuppressive therapy. The subject invention is contemplated for use with...
9174969 Indoline scaffold SHP-2 inhibitors and cancer treatment method  
The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: whereinX, Y, and Z...
9173907 Method of prenatal administration of mammalian umbilical cord stem cells for the intrauterine treatment of sanfilippo syndrome  
A method of treating a fetus or embryo suspected of having a congenital condition that involves an abnormal or missing protein, the method has the steps of a. providing a plurality of human...
US20150306068 COMPOUNDS AND RELATED METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES  
Aspects of the invention pertain to chemical compounds, therapeutic compositions, and methods for treating neurodegenerative diseases, in particular, neurodegenerative diseases associated with...
US20150305764 POWER MORCELLATION IN A PROTECTED ENVIRONMENT  
A power morcellation system, apparatus, and methodology. Structurally, the device includes a sturdy, pliable (e.g., able to be inserted and retracted through a 10-15 mm morcellator port),...
9169230 (−)-Epigallocatechin gallate derivatives for inhibiting proteasome  
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
US20150301063 SALIVARY INFLAMMATORY BIOMARKERS ASSOCIATED WITH GLYCEMIC CONTROL AND ORAL HEALTH  
The present invention provides non-invasive diagnostic methods and kits for determining and/or monitoring oral health and glycemic control in subjects with Type 1 diabetes.
US20150297621 COMPOSITIONS INCLUDING TRICIRIBINE AND TAXANES AND METHODS OF USE THEREOF  
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer,...
9163374 Use of cactus mucilage as a dispersant and absorbant for oil in oil-water mixtures  
Despite advances in off-shore oil exploration and drilling technology, accidental oil spills do occur. Depending on their magnitude and location, irreparable damage may be inflicted on marine and...
9163071 POP2: NKκB-inhibiting polypeptides, nucleic acids and methods of use  
This invention provides a novel pyrin-only protein (POP2), polypeptides, and nucleic acids encoding them and methods for making and using them. POP2 is a 294 nt single exon gene located on human...
9161901 Nanoparticle targeted drug delivery to the lungs using extra-testicular Sertoli cells  
A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of...
US20150291641 Metal-Organic Materials (MOMS) for Adsorption of Polarizable Gases and Methods of Using MOMS  
Embodiments of the present disclosure provide for multi-component metal-organic materials (MOMs), systems including the MOM, systems for separating components in a gas, methods of separating...
9160305 Capacitively and piezoelectrically transduced micromechanical resonators  
In one embodiment, a hybrid micromechanical resonator includes a capacitive resonator element and a piezoelectric resonator element, wherein the resonator can be capacitively and piezoelectrically...
9155872 Drug delivery device for ovarian cancer  
A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular...