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Patents and Patent Applications from University of South Florida


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8927243 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
US20150004698 SUBSTRATE-MIMETIC AKT INHIBITOR  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue...
US20150004592 SAMPLE STORAGE FOR MOLECULAR AND IMMUNOLOGICAL DETECTION  
A method for the direct molecular analysis of nucleic acid or antibodies from a natural or synthetic solid matrix for storing, preserving, and transporting nucleic acid or antibodies samples and...
8924536 Distributed and decentralized location aware architecture  
Provided is a distributed and decentralized location-aware system. The system includes a number of peers, each in communication with other peers and adapted to communicate PING, PONG, and ALERT...
8923773 Minimally invasive networked surgical system and method  
A system for performing non-invasive networked medical procedures including a number of in vivo medical devices, a communication path between at least two of the devices, an ex vivo control unit to...
8922452 Periodic spiral antennas  
In one embodiment, a periodic spiral antenna includes first and second arms that form interleaved spirals parallel to an x-y plane, wherein the arms have a height dimension that extends along a z...
8922272 System and method for voltage regulator-gating  
A system and method for adaptive activity management of on-chip voltage regulators based upon the workload information is provided to force each on-chip regulator to operate in its most...
8921312 Combination of insulin and ascorbate to enhance wound healing  
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without...
8920700 Telescopic nanotube device for hot nanolithography  
A device for maintaining a constant tip-surface distance for producing nanolithography patterns on a surface using a telescopic nanotube for hot nanolithography. An outer nanotube is attached to an...
8920426 Apparatus for osteotomy and graft preparation  
Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side...
US20140378516 COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT  
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition...
8916698 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8916343 DNA biochip and methods of use  
The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized the...
US20140371208 METHODS OF TREATING DISEASE-INDUCED ATAXIA AND NON-ATAXIC IMBALANCE  
Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.
US20140370510 MODULATION OF PEPTIDOME USING HISTONE DEACETYLASE INHIBITOR  
Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the...
US20140369983 ISCHEMIC TISSUE CELL THERAPY  
The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present...
US20140367258 SYSTEM AND METHOD FOR ELECTROWETTING ACTUATION UTILIZING DIODES  
An electrowetting system and method for the movement of a droplet across the surface of a substrate, utilizing an applied voltage. The actuation of the droplet is achieved by introducing a diode...
8914102 Method and device for anesthesiology measurement and control  
Cell or tissue permeability to electrical signals can be used to determine the depth of anesthesia of a patient. A method and device is presented to measure, record and control the effects of...
8912006 Microfluidic device for generating neural cells to simulate post-stroke conditions  
This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a...
D719071 Omnidirectional mobility device  
8908796 Orthogonal frequency division multiplexing (OFDM) transmitter and receiver windowing for adjacent channel interference (ACI) suppression and rejection  
An optimum time domain windowing scheme for orthogonal frequency-division multiplexing (OFDM)-based waveforms in the sense of spectral concentration is proposed. Instead of evenly suppressing the...
8908089 Implantable imaging device  
An imaging device for in vivo medical applications that enables minimally invasive surgical procedures. The imaging device includes an elongated frame having a base, a module housing, and an...
8906918 Compositions, methods of use, and methods of treatment  
Embodiments of the present disclosure, in one aspect, relate to a 2,4-diaminoquinazoline compound, pharmaceutical compositions including a 2,4-diaminoquinazoline compound, methods of treatment of a...
8906869 Effective treatment of ovarian cancer using triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to...
8906414 Methods and compositions for improving bioavailability of epigallocatechin gallate (EGCG)  
Compositions and methods of increasing the bioavailability of catechins are presented. Compositions for increasing the bioavailability of catechins include compositions where the catechin is added...
8906052 Method and device for the treatment of hypertrophic cardiomyopathy  
A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device...
US20140356955 FERROMAGNETIC CELL AND TISSUE CULTURE MICROCARRIERS  
A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also provided...
8901086 Compositions including triciribine and methods of use thereof  
This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates...
US20140350105 COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS  
Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of...
US20140350052 Methods and Compositions for Reducing Serum Levels of Immunoglobulin E (IGE)  
The present disclosure provides methods and pharmaceutical compositions for reducing the serum level of immunoglobulin IgE in an animal or human subject. It has been found that reducing or...
8895248 Method for detecting Salmonella species by assaying outer membrane Porin F (ompF)  
The invention relates to a method of detecting the presence of Salmonella in a sample using novel oligonucleotide sequences. Also presented is a kit for putting the method into practice and novel...
US20140343120 METHODS AND COMPOSITIONS FOR REDUCING ACTIVITY OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR AND FOR TREATMENT OF DISEASES  
Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of...
8891430 Edge windowing of OFDM based systems  
Various methods and systems are provided for edge windowing of orthogonal frequency division multiplexing (OFDM) systems. In one example, among others, a method includes obtaining an edge windowing...
US20140336945 GENE SIGNATURE FOR THE PREDICTION OF RADIATION THERAPY RESPONSE  
Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a...
US20140336239 COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS  
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223...
8883744 Method and composition for modulating canonical Wnt pathway using folate and inositol  
The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure...
8881639 Hybrid body armor  
In one embodiment, hybrid body armor includes a ballistic fabric and a plurality of small ballistic plates arranged in a tightly packed array over the ballistic fabric.
US20140330123 IMPLANTABLE SONIC WINDOWS  
A sonic window includes a body sized and configured to close an opening formed through the cranium, wherein at least a part of the body is made of a sonically transparent material through which...
US20140329900 SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY  
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization,...
US20140329791 COMPOUNDS AND RELATED METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES  
Aspects of the invention pertain to chemical compounds, therapeutic compositions, and methods for treating neurodegenerative diseases, in particular, neurodegenerative diseases associated with...
8877752 4(1H)-quinolones having antimalarial activity with reduced chemical resistance  
Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced...
US20140322227 PEPTIDES FOR TREATMENT OF BONE DEFICIENCY AND AUTOIMMUNE DISORDERS  
The present invention concerns the use of HYD1 peptides to reduce activated T-cell numbers and/or to promote bone preservation in vivo. The present invention concerns methods of treating a bone...
8872725 Electronically-tunable flexible low profile microwave antenna  
A low profile antenna that provides high isolation to back-side radiation, is flexible to allow conformal mounting to a surface, and can be tuned over a wide frequency range is conceived. The...
US20140316570 SYSTEMS AND METHODS FOR COMMUNICATING ROBOT INTENTIONS TO HUMAN BEINGS  
In one embodiment, communicating robot intentions to human beings involves determining movements that a robot will make to complete a task, visually communicating a long-term intention of the robot...
8865666 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment...
8864852 Method for the fabrication of electrolyte cavities using surface micromachining  
The present invention is directed to the fabrication of thin aluminum anode batteries using a highly reproducible process that enables high volume manufacturing of the galvanic cells. A method of...
8863737 Sustained modulation of temperature of self heating chemical system  
Exothermic reactions are used in self heating products, such as food, beverages, and clothing. Temperature peaks are important as heat can cause user injuries or increase pressures within the...
US20140309477 CT ATLAS OF THE BRISBANE 2000 SYSTEM OF LIVER ANATOMY FOR RADIATION ONCOLOGISTS  
The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of hepatic anatomical information including three orders of division and obtaining...
US20140309476 CT ATLAS OF MUSCULOSKELETAL ANATOMY TO GUIDE TREATMENT OF SARCOMA  
The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of musculoskeletal structure. The atlas contains a data set representing a 3D model...
8858772 Bidirectional electrowetting actuation with voltage polarity dependence  
A novel electrowetting system for the smooth continuous movement of a droplet across a single circuit using a continuous applied voltage regardless of polarity. The actuation of the droplet is...