Patents and Patent Applications from University of South Florida


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US20170144099 METAL-ORGANIC MATERIALS (MOMS) FOR CO2 ADSORPTION AND METHODS OF USING MOMS  
Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of...
US20170143769 HUMAN UMBILICAL CORD BLOOD-DERIVED MONOCYTES FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND DISORDERS  
Human umbilical cord blood-derived monocytes that markedly promote Aβ clearance through heterodimerization of sAPPα with Aβ and resultant sAPPα production for prevention or treatment of...
9659160 System and methods for authentication using multiple devices  
A system and method of authentication using an authenticator computing device and at least two registered user devices is described. In operation, the authenticator computing device receives a...
9656953 Inhibition of cell proliferation  
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly...
9655914 Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof  
This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions...
9655901 Methods of treating Nfa-1 organism infection using allopurinol  
Described herein is allopurinol and pharmaceutical formulations thereof that can be administered to a subject infected with or suspected of being infected with an organism having an Nfa-1 protein...
US20170140672 RADIAL ARM MODEL WITH MESH  
A radial arm model in combination with a two-way mesh to permit puncturing, dissection/transection, and suturing of the underlying simulation vessels. The current invention also includes a method...
US20170137812 COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS  
Provided are methods of treating an inflammatory disease in a subject in need thereof by administering an amount of microRNA 142, an amount of microRNA 223 or an amount of microRNA 142 and an...
9651357 Systems and methods for determining strand position in a post-tensioned tendon  
In one embodiment, systems and methods for determining the positions of strands in a post-tensioned tendon involve positioning a magnet in close proximity to the outer surface of a tendon, moving...
9650828 Variable screens  
In one embodiment, a variable screen includes a first panel including elongated slats having a fixed end and a free end, the slats being flexible so that they can bend without breaking, and a...
9649764 Systems and methods for planning a robot grasp that can withstand task disturbances  
In one embodiment, a system and method for planning a robot grasp involve measuring interaction forces imposed on an object by an environment while a task is demonstrated using the object to...
9649120 Minimally invasive surgery platform attachment apparatus  
An apparatus for the insertion, placement, attachment, and removal of a surgical device includes a handle and an elongate shaft. Opposing spring fingers that open and close relative to one another...
9646423 Systems and methods for providing augmented reality in minimally invasive surgery  
In one embodiment, a method for providing augmented reality in minimally invasive surgery includes capturing pre-operative image data of internal organs of a patient, capturing intra-operative...
9645155 Methods of synthesizing γ-aapeptides, γ-aapeptide building blocks, γ-aapeptide libraries, and γ-aapeptide inhibitors of Aβ40 aggregates  
Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide...
9642843 Pharmaceutical compounds and use of same in cancer and tauopathies  
Disclosed are compounds of formula (1)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or...
9636311 N,N′-di-1 naphthylguanidine HCl (NAGH) and N,N′-di-p-nitrophenylguanidine HCl (NAD) treatment for stroke at delayed timepoints  
A method of treating stroke by administration of a novel sigma agonist is presented. Twenty-four hours after MCAO, systemic administration of several novel sigma agonists including: Bromo-DTG;...
US20170113204 METAL-ORGANIC MATERIALS FOR C02 ADSORPTION  
Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of...
9632076 Microfluidic device for generating neural cells to simulate post-stroke conditions  
This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and...
9629651 Device for the treatment of hypertrophic cardiomyopathy  
A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device...
9629650 Small diameter laparoscopic tool having releasable tip  
A laparoscopy tool includes a sheath and a control wire slideably disposed within a lumen of the sheath. The sheath has a diameter of less than 1.6 mm and is introduced through an abdominal...
US20170108829 Systems and Methods for Performing Self-Interference Incoherent Digital Holography  
In one embodiment, a self-interference incoherent digital holography system including a light sensor and a diffractive filter configured to receive light from an object to be holographically...
US20170106019 COMPOSITIONS AND METHODS FOR MITIGATING DRUG RESISTANT BACTERIA  
The current invention is a broad-based remediation mechanism against MRFs and includes nanotechnology formulations and methodologies that may be used to develop novel mitigation strategies against...
9624473 Three-dimensional fibrous scaffolds for cell culture  
Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a...
9623214 Method of dilating gastrointestinal strictures using a trans-endoscopic hydraulic balloon apparatus  
A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid...
9622842 Rodent immobilization apparatus and method of use thereof  
A rodent immobilizing apparatus for use during experimental procedures, dissection, and sample procurement. The apparatus has two (2) points of adherence to the dissection board, one at the...
US20170101439 GAMMA-AA-PEPTIDE STAT3/DNA INHIBITORS AND METHODS OF USE  
STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been recognized as a promising target for cancer...
US20170100506 PROTEASE RESISTANT GROWTH FACTOR FORMULATIONS FOR CHRONIC WOUND HEALING  
A formulation and method of treating chronic wounds is presented. The formulation uses two different fusion peptides, one of which incorporates an elastase resistant peptide, to preserve the...
9618501 Three-dimensional fibrous scaffolds for cell culture  
Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a...
9618002 Mini notched turbine generator  
The present invention is turbine generator capable of integration into a bio-physiological or microfluidic system. The generator can convert biomechanical energy into electrical energy by using...
9616138 Cargo carrying nanoparticles  
Disclosed herein are cargo carrying nanoparticles and pharmaceutical formulations thereof. The cargo carrying nanoparticles can self-assemble from cargo molecule subunits and/or targeting...
9610364 Method for the treatment of malignancies  
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently...
US20170088524 Compositions, Methods of Use, And Methods of Treatment  
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition...
9604923 Small molecule inhibitors of STAT3 with anti-tumor activity  
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization,...
9604195 Metal-organic materials (MOMs) for CO2 adsorption and methods of using MOMs  
Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of...
9603869 Lithium co-crystals and an additional neuropsychiatric agent for treatment of neuropsychiatric disorders  
The invention concerns methods and compositions for treating a neuropsychiatric disorder, wherein the method comprises administering an effective amount of a co-crystal of lithium to a subject in...
US20170082602 Systems and Methods for Analyzing Liquids  
In one embodiment, an optical spectroscopy probe includes an optical fiber having a distal tip and a microfluidic filtering chamber attached to the distal tip of the optical fiber, the chamber...
US20170081635 TUMOR-INFILTRATING LYMPHOCYTES FOR ADOPTIVE CELL THERAPY  
Disclosed are compositions and methods for ex vivo expansion of tumorinfiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an...
US20170081225 Portable Wastewater Treatment Systems  
In one embodiment, a portable wastewater treatment system includes an anaerobic reactor in which organic material within the wastewater can be broken down, a membrane filter that receives...
US20170080007 EFFECTIVE TREATMENT OF ESOPHAGEAL ADENOCARCINOMA USING TRICIRIBINE AND RELATED COMPOUNDS  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering...
9598338 Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases  
The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated...
US20170071566 ELECTRONIC CATHETER STETHOSCOPE  
An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in...
US20170071496 RADIOLOGICALLY IDENTIFIED TUMOR HABITATS  
Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed...
9593070 Exo-S-mecamylamine formulation and use in treatment  
A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in...
US20170067005 CONCENTRICALLY BAFFLED REACTORS AND SYSTEMS THAT INCORPORATE THEM  
In one embodiment, a concentrically baffled reactor includes an outer housing that defines an interior space, an inlet through which material can be delivered into the interior space, an outlet...
US20170065643 METHOD OF STEM CELL DELIVERY INTO THE BRAIN DURING CHRONIC DISEASE USING BLOOD BRAIN BARRIER PERMEABILIZERS  
Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate the entry of stem cells from the periphery to the stroke brain. It is unknown whether BBB permeation in the chronic stage...
US20170065564 BIS-CYCLIC GUANIDINE COMPOUND COMPOSITIONS, METHODS OF USE AND TREATMENT THEREOF  
The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition...
US20170062072 Physically unclonable function based on domain wall memory and method of use  
A system and method for providing a physically unclonable function (PFU) is described. In operation, the method includes applying a domain wall shift pulse challenge to a plurality of nanowires of...
US20170060417 MAGNETIC COPROCESSOR AND METHOD OF USE  
A magnetic system for solving a quadratic optimization problem by associating each of a plurality of variables of a quadratic optimization problem with a nanomagnet of a nanomagnet array, driving...
US20170058432 Polypeptide Electrospun Nanofibrils of Defined Composition  
Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the...
US20170058264 FORMATION OF MULTICELLULAR TUMOROIDS AND USES THEREOF  
Described herein are compositions and methods of forming multi-cellular tumoroids. Also described herein are methods of using the multi-cellular tumoroids.