Patents and Patent Applications from University of South Florida


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9526885 Microneedles with sharpened tips and corresponding method of fabrication  
Microneedles with sharpened tips are fabricated without any reduction to the shaft diameter below the tip. By sharpening the tip and not the entire length of the microneedle, their mechanical...
US20160369247 SUBSTRATE-MIMETIC AKT INHIBITOR  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3...
9522114 Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin  
Specific drug delivery to tumor cells without affecting normal cells is a major challenge in cancer treatment. The present invention incorporates embedding nonionic surfactant vesicles (niosomes)...
9520110 String vibration frequency altering shape  
The present invention is a novel variable tension string instrument that relies on a kinetic shape to actively alter the tension of a fixed length taut string. A mathematical model was derived...
9520072 Systems and methods for projecting images onto an object  
In one embodiment, a method for projecting images on a subject includes determining a pose and position of the subject, adjusting a three-dimensional model of an anatomical structure of the...
9518079 Effective treatment of tumors and cancer with triciribine and related compounds  
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination of (i) administering triciribine...
9517598 Method for making self-assembling, collagen-based material for corneal replacement  
A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into...
US20160354227 CUSTOM REDUCTION SPLINT FOR EDENTULOUS PATIENTS  
A custom oral splint that is operatively secured to the maxilla and mandible of a subject/patient to assist in reduction and provide maintenance of reduction of maxillary and mandibular fractures...
9515209 Bare quantum dots superlattice photonic devices  
Manipulation of the passivation ligands of colloidal quantum dots and use in QD electronics. A multi-step electrostatic process is described which creates bare QDs, followed by the formation of QD...
9514658 Synthetic skin and tissue model  
A synthetic tissue model using one or more semi-flexible polymers or resin with at least one embedded mesh material is provided herein. The model provides suitable simulation of animal tissue...
9513286 Differentially expressed genes in large granular lymphocyte leukemia  
The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL....
9512160 Antibacterial S-heterosubstituted disulfides  
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant...
9511348 Functionalized porous organic polymers for olefin/paraffin separations  
Compositions containing a porous organic polymer and a monovalent metal cation are provided for separation/purification of olefins and paraffins. The compositions can be stable and recyclable. The...
9511084 Compositions including triciribine and methods of use thereof  
This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates...
US20160351341 Microstructured Crystalline Device In Confined Space, A Dye-Sensitized Solar Cell, and Method of Preparation Thereof  
A method of forming an ordered nanorods array in a confined space is used to form a high surface area device where an ensemble of parallel trenches has micrometer dimensions for the width and...
9505623 One-step synthesis of graphene quantum dots  
Methods of making graphene quantums dots are provided. The methods can produce graphene quantum dots with a monodisperse size distribution. The graphene quantum dots are produced, via one-pot...
9504986 Metal-organic materials (MOMS) for polarizable gas adsorption and methods of using MOMS  
Embodiments of the present disclosure provide for multi-component metal-organic materials (MOMs) systems that exhibit permanent porosity and using MOMs to separate components in a gas mixture,...
9504440 Electronic catheter stethoscope  
An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in...
US20160340566 METHOD OF MODULATED EXOTHERMIC CHEMICAL SYSTEMS THROUGH PHASE CHANGE MATERIALS  
The chemical reactions modulation of temperature and dissipate heat through using phase change materials (PCM). Hydration of a mixture composed of encapsulated and/or non-encapsulated oxides such...
US20160339055 LITHIUM CO-CRYSTALS FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
The invention concerns methods and compositions for treating a neuropsychiatric disorder, wherein the method comprises administering an effective amount of a co-crystal of lithium to a subject in...
US20160338969 BIOCOMPATIBLE POLYACRYLATE COMPOSITIONS AND METHODS OF USE  
A biocompatible polymer material is described that exhibits mechanical and physical properties that are fundamental to many medical devices and treatment of many medical diseases and disorders....
US20160338962 POLY(VINYL BENZOATE) NANOPARTICLES FOR MOLECULAR DELIVERY  
The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using...
US20160338682 PNEUMATIC SYSTEM AND METHOD FOR INTERMITTENTLY RIGIDIFYING AN ENDOSCOPIC SPECIMEN RETAINING CARRIER  
An insufflation/desufflation apparatus/system, and method of use thereof. An airtight tube is secured circumferentially to the opening of an endoscopic containment bag. The tube is attached to a...
9501946 Systems and methods for stable haptic feedback over packet-switched networks  
Providing haptic feedback to a user over a packet-switched network includes sensing movement of a haptic device by a user, the haptic device being configured to control a first virtual object...
9499587 Gamma-AApeptides with potent and broad-spectrum antimicrobial activity  
The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides,...
9498492 Compositions including triciribine and taxanes and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer,...
US20160335223 METHODS AND SYSTEMS FOR COMPUTATION OF BILEVEL MIXED INTEGER PROGRAMMING PROBLEMS  
Techniques and systems are disclosed for improving the computation and solution of bilevel MIP problems. Various single-level reformulation techniques can be used to transform a bilevel MIP...
US20160331746 Sortilin-Binding Small Molecules for Increasing Glucose Uptake  
Various scaffolds of small molecules capable of binding to the active site of sortilin are identified by in silico methods. These scaffolds include norbornene anhydride amino acid adducts,...
US20160331314 MATERIALS AND METHODS FOR DETECTING AND MONITORING EDEMA AND RELATED CONDITIONS  
The subject invention provides a Coupled Domain Sensor (CDS) that can be used to, for example, evaluate hydration and occlusion of blood in patients with edema using electrical and optical...
9493825 Materials and methods for profiling microRNAs  
The present invention provides materials and methods for detecting, quantifying, and/or high-throughput-profiling microRNAs. Advantageously, the present invention is more sensitive and specific...
9493695 Method of encapsulating a phase change material with a metal oxide  
Storage systems based on latent heat storage have high-energy storage density, which reduces the footprint of the system and the cost. However, phase change materials (PCMs), such as NaNO3, NaCl,...
9492778 Metal-organic materials (MOMS) for CO2 adsorption and methods of using MOMS  
Embodiments of the present disclosure provide for hydrophobic multi-component metal-organic materials (MOMs) (also referred to as “hydrophobic MOM”), systems that exhibit permanent porosity and...
9492455 Methods of treating NFA-1 organism infection using apocynin  
Described herein are compounds and pharmaceutical formulations thereof that can be administered to a subject infected with or suspected of being infected with an organism having an Nfa-1 protein....
US20160329202 SYSTEMS AND METHODS FOR BUBBLE BASED ION SOURCES  
The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, a heat source positioned above the...
9486626 Passive electric field focus system for in vivo and in vitro applications  
The present invention provides a system and method of directing, focusing, or concentrating electrical charges within a defined electric field so that these charges can be used to exert forces on...
9486522 Compositions including triciribine and trastuzumab and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and...
9486492 Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof  
This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the...
9486470 Compositions including triciribine and one or more platinum compounds and methods of use thereof  
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and...
US20160322566 METHOD OF MANUFACTURE FOR A PARTIALLY-SPRAYED LAYER ORGANIC SOLAR PHOTOVOLTAIC CELL  
The fabrication and characterization of large scale inverted organic solar array fabricated using all-spray process is disclosed. Solar illumination has been demonstrated to improve transparent...
US20160322093 Non-Volatile Flip-Flop with Enhanced-Scan Capability to Sustain Sudden Power Failure  
Non-volatile flip-flops (NVFFs) based circuitries and schemes that incorporate magnetic tunnel junctions (MTJs) are provided to ensure fast data storage and restoration from an intentional or...
US20160317487 METHODS OF SUSTAINING DIETARY KETOSIS AND ITS EFFECTS ON LIPID PROFILE  
The ketogenic diet (KD) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mM)...
US20160317271 METHOD OF TREATING PELVIC PROLAPSE USING A SACROCOLPOPEXY/SACROCERVICOPEXY VAGINAL POSITIONING AND MESH RETENTION SYSTEM  
A method of treating pelvic prolapse is presented herein. Vaginal support device contains flat superior and inferior surfaces to facilitate affixing of mesh to vagina. Vaginal support device may...
9485037 Compact dual-channel transceivers  
In one embodiment, a dual-channel transceiver includes two harmonic repeaters each having a receive antenna, a transmit antenna, and a frequency multiplier connected to the antennas that is...
9481972 Systems and methods for splicing pile segments  
In one embodiment, a pile splicing system and method uses a pile segment adapted to form part of a spliced pile, the pile segment including an elongated concrete body having first and second ends,...
9481864 Conversion of non-neuronal cells into neurons  
The subject invention concerns materials and methods for conversion of non-neuronal cells into neurons. The subject invention also concerns methods for screening drugs and other compounds for...
9481821 Method of modulated exothermic chemical systems through phase change materials  
The chemical reactions modulation of temperature and dissipate heat through using phase change materials (PCM). Hydration of a mixture composed of encapsulated and/or non-encapsulated oxides such...
US20160312222 MANGANESE ION COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION  
The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing...
US20160310160 INCISION-LESS LAPAROSCOPIC INSTRUMENT  
A laparoscopic instrument is placed into the abdomen without the creation of a skin incision. The laparoscopic instrument includes a shaft that does not exceed 1.6 mm in diameter. The shaft has a...
9479375 Joint physical layer security and PAPR mitigation in OFDM systems  
Systems and methods for securing orthogonal frequency division multiplexing (OFDM) transmission of data are discussed herein. Transceivers can sense the signal strength of frequencies on an OFDM...
9476025 Ferromagnetic cell and tissue culture microcarriers  
A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also...