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Patents and Patent Applications from University of South Florida


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US20140258356 COLUMN AND CONSTRAINT GENERATION METHOD FOR OPTIMAL STRATEGIES  
Optimization processes, which are parameter driven for solving interdiction problems, for example, power grid interdiction problems, are provided. An algorithm of the subject invention can include...
US20140255337 METHODS OF TREATING COGNITIVE IMPAIRMENT  
The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or...
8828451 Akt sensitization of cancer cells  
Most human tumors find ways to resist anticancer drug monotherapy. Akt is considered a likely peptide providing such monotherapy drug resistance. Data indicates that Akt chemoresistance is induced...
US20140248364 DIVALENT-METAL COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION  
The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing...
8822524 Substrate-mimetic Akt inhibitor  
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue...
US20140242193 LITHIUM COMPOSITIONS  
2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic...
8816784 Silicon-based atomic clocks  
In one embodiment, a silicon-based atomic clock for use in an electronic device includes a single-isotope silicon crystal and energy level transitions within the silicon are used as a frequency...
8815502 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8815260 Treatment of restenosis and stenosis with dasatinib  
A method for treating or inhibiting artery obstructive disease, such as restenosis after angioplasty and stenting procedures and stenosis after coronary artery bypass surgery, in a subject by...
8815144 Carbon nanotube/polymer composites resistant to ionizing radiation  
Polymer composites directed to single wall carbon nanotubes (SWNT) dispersed within poly(methyl methacrylate) (PMMA) and their methods of synthesis. Composites of the present invention are also...
US20140235659 DELTA-TOCOTRIENOL TREATMENT AND PREVENTION OF PANCREATIC CANCER  
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these...
US20140235565 N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS  
The present invention provides N-alkylthio β-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and ...
US20140234401 METHOD OF TREATING INFLAMMATION USING HUMAN IMMUNOSUPPRESSIVE PROTEIN  
A method of treating inflammation by administering a therapeutically effective amount of a human immunosuppressant protein (HISP) to a subject is presented. The inventors have discovered a novel...
8808301 Rapid custom intra-articular ligament reconstruction guide  
Custom surgical guides based on the patient's unique anatomy that can be quickly and accurately applied intra-operatively without navigation are disclosed. The device is created using preoperative...
8803533 Noncontact determination of interface trap density for semiconductor-dielectric interface structures  
Embodiments of the subject method and apparatus relate to a sequence of noncontact Corona-Kelvin Metrology that allows the determination and monitoring of interface properties in dielectric/wide...
8802647 Materials and methods for prevention and treatment of RNA viral diseases  
The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient....
8802643 Method for the treatment of malignancies  
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently...
8802638 Flavonoid treatment of glycogen synthase kinase-based disease  
The flavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes pr...
US20140221658 INHIBITION OF CELL PROLIFERATION  
The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly...
US20140221473 Compositions, Methods of Use, and Methods of Treatment  
Embodiments of the present disclosure provide compositions including ketamine analogues, salts, and disalts, pharmaceutical compositions including ketamine analogues, salts, or disalts, methods of...
8796235 Methods for attenuating dengue virus infection  
The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression...
8795498 Microbial cell and particle selection system and method of use  
The invention comprises two key components: dielectrophoresis (DEP) and reversible binding surfaces. DEP has become an important tool for trapping dielectric particles. Moreover, DEP can manipulate...
8793849 Method of manufacturing high frequency thickness shear mode gas and organic vapor sensors  
A method of fabricating a thickness shear mode (TSM) gas and organic vapor sensor having a visco-elastic polymer coating and a fundamental frequency greater than 20 MHz. The method begins by...
US20140213802 (-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome  
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
US20140213604 PROTEIN KINASE C AS A TARGET FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS  
The subject invention concerns a method of inhibiting respiratory syncytial virus (RSV) infection in a patient by decreasing the endogenous protein kinase C (PKC) activity within the patient....
US20140209564 Method for the Fabrication of Electrolyte Cavities Using Surface Micromachining  
The present invention is directed to the fabrication of thin aluminum anode batteries using a highly reproducible process that enables high volume manufacturing of the galvanic cells. A method of...
US20140205570 RECOMBINANT ADENO-ASSOCIATED VIRUS-MEDIATED EXPRESSION OF FRACTALKINE FOR TREATMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE DISEASES  
The subject invention pertains to the use of fractalkine (FKN, CX3CL1) and its receptor CX3CR1 for treatment of neuroinflammation and/or neurodegeneration. In one embodiment, the present invention...
8788015 Method of rapidly visualizing essential neural pathways  
A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and...
8785176 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8784832 Synthetic antigen based on the ligand domain of the Plasmodium vivax duffy binding protein  
The disclosure provides compositions that are useful for eliciting a strain-transcending immune response in an animal or human directed against the blood-stage of the malarial parasite Plasmodium...
8784802 Ischemic tissue cell therapy  
The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present...
8783242 Charcoal grill having re-chargeable charcoal feed for continuous operation  
A charcoal grill includes a base for holding charcoal, support legs, and a lid mounted to the base. A metal band, having an opening formed therein, encircles the base. A box is secured to the metal...
US20140197355 METHOD OF ENCAPSULATING A PHASE CHANGE MATERIAL WITH A METAL OXIDE  
Storage systems based on latent heat storage have high-energy storage density, which reduces the footprint of the system and the cost. However, phase change materials (PCMs), such as NaNO3, NaCl,...
8778986 Treatment of glycogen synthase kinase-based disease  
The bioflavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes pr...
8778894 Luteolin and diosmin/diosmetin as novel STAT3 inhibitors for treating autism  
The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form,...
8778680 Stable differentiation of NT2 cells  
A method of differentiating adult stem cells, such as those derived from a teratocarcinoma cell line, the Ntera2/D1 clone (NT2). The developed cells exhibit a stable neurotransmitter phenotype...
US20140194834 Auto-Regulation System for Intraocular Pressure  
A device and system for controlling pressure via fluid exchange in the body is presented. The device and system may be used to control intraocular eye pressure. The system is comprised of four main...
US20140194719 Long-Term Implantable Silicon Carbide Neural Interface Device Using the Electrical Field Effect  
Field effect devices, such as capacitors and field effect transistors, are used to interact with neurons. Cubic silicon carbide is biocompatible with the neuronal environment and has the chemical...
US20140194495 CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION  
The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts...
US20140190898 Cactus Mucilage and Ferric Ions for the Removal of Arsenate (As(V)) from Water  
Potable drinking water is plagued with widespread arsenic contamination, particularly in developing communities. Ferric ions were introduced to interact with arsenate based on the strong affinity...
8770664 Reclining chair with two positions of repose  
A reclining chair having two stable positions of repose: an upright position and a reclined position. The chair having two peripheral supports and multiple intermediate supports disposed between...
US20140186316 METHODS AND COMPOSITIONS FOR TREATMENT OF TRAUMATIC BRAIN INJURY AND FOR MODULATION OF MIGRATION OF NEUROGENIC CELLS  
Disclosed herein are methods for the treatment of traumatic brain injury by transplantation of cells descended from marrow adherent stem cells that express an exogenous Notch intracellular domain....
8765119 Treating amyotrophic lateral sclerosis (ALS)with isolated aldehyde dehydrogenase-positive umbilical cord blood cells  
A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase...
US20140179979 THERAPEUTIC AGENT APPLICATORS AND METHODS OF USING THE SAME  
The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic...
D707613 Wiper blade ornament  
D707612 Wiper blade ornament  
D707611 Wiper blade ornament  
8759662 Bulk dimensional nanocomposites for thermoelectric applications  
Thermoelectric elements may be used for heat sensors, heat pumps, and thermoelectric generators. A quantum-dot or nano-scale grain size polycrystalline material the effects of size-quantization are...
8759479 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8759317 Method of treatment of cancer using guanosine 3′, 5′ cyclic monophosphate (cyclic GMP)  
A method of treating cancer through use of guanosine 3′,5′-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as sma...