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US20120130486 |
MULTIFOCAL OPHTHALMIC LENS DESIGNS USING WAVEFRONT INTERACTION
An intraocular lens introduces higher order aberrations, e.g., spherical aberration (SA), for different sub-optical zone diameters. For example, a lens may have a central sub-optical zone which...
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US20120127432 |
MEASURING OCULAR POINT SPREAD FUNCTION USING ADAPTIVE OPTICS
Measurement of the optical point spread function through a double-pass technique is enhanced by using adaptive optics to form a tiny spot of light on the retina.
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US20120127431 |
SCANNING OPTICAL SYSTEM FOR LARGE AXIAL SCAN DEPTH ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY (OCT)
An optical coherence tomography scanning system includes a lens divided into two halves: one optimized to achieve normal incidence angles on the posterior surface of the eye's lens, the other...
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8183345 |
Recombinant factor VIII having reduced inactivation by activated protein C
The present invention relates to a recombinant factor VIII that is characterized by one or more mutations within a region surrounding an activated protein C cleavage site, which one or more...
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8182590 |
Ultrathin porous nanoscale membranes, methods of making, and uses thereof
A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor...
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US20120123534 |
MODIFIED MONOVISION BY EXTENDING DEPTH OF FOCUS
Depth-of-focus (DoF) is extended in a presbyopic patient by inducing different higher order aberrations, e.g. spherical aberration, to each of the two eyes. That method will result in improving...
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US20120122872 |
Treatment or Prevention of Fungal Infections with PDK1 Inhibitors
Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection and administering to the...
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8180971 |
System and method for hardware acceleration of a software transactional memory
In a transactional memory technique, hardware serves simply to optimize the performance of transactions that are controlled fundamentally by software. The hardware support reduces the overhead of...
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US20120114670 |
METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC RESPONSES TO ONCOGENIC MUTATIONS
Disclosed are compositions and methods related to new targets for cancer treatment.
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8172873 |
Shape memory polymers
The present disclosure relates to Shape Memory Polymers (SMP's) comprising function groups that allow the polymers to be elastically deformed, utilized in the elastically deformed state, and...
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US20120095336 |
ROBOTIC LOCALIZING AID FOR HIGH-INTENSITY FOCUSED ULTRASOUND DELIVERY
A holding structure holds a biopsy needle and a HIFU transducer to allow smooth and accurate delivery of the HIFU beam at the interface of the liver, where bleeding will occur. This manipulator...
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8158770 |
Content dependent inhibitors of cytidine deaminases and uses thereof
This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof.
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US20120088985 |
METHODS AND SYSTEMS FOR MEASURING AND COMMUNICATING PAIN AND DISTRESS LEVEL
Systems and methods are described for communicating the distress or pain experienced by an infant or a non-communicative patient. The systems and methods can provide an objective quantification of...
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US20120070886 |
MICROFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE MICROFLUIDIC DEVICE
A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS)....
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US20120067855 |
FEMTOSECOND LASER PULSE SURFACE STRUCTURING METHODS AND MATERIALS RESULTING THEREFROM
Embodiments of the present invention are generally directed to materials processing methods using femtosecond duration laser pulses, and to the altered materials obtained by such methods. The...
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US20120065136 |
RECOMBINANT FACTOR VIII HAVING ENHANCED STABILITY FOLLOWING MUTATION AT THE A1-C2 DOMAIN INTERFACE
The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include...
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US20120062979 |
DIGITAL BINARY MEMS WAVEFRONT CONTROL
A phase screen, i.e., an opto-electronic device that can convert a distorted incoming optical wavefront into a plane wave or, conversely, transform a plane wave into a prescribed varying output...
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US20120059439 |
ABERRATION CONTROL BY CORNEAL COLLAGEN CROSSLINKING COMBINED WITH BEAM-SHAPING TECHNIQUE
Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A...
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US20120058950 |
DETECTION OF NEUROPEPTIDES ASSOCIATED WITH PELVIC PAIN DISORDERS AND USES THEREOF
Diagnostic assessment and therapeutic treatment of pelvic pain disorders, including bladder disorders, bowel disorders, and/or reproductive tissue or organ disorders that are characterized by...
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8131475 |
Methods for identifying, diagnosing, and predicting survival of lymphomas
Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate...
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8129072 |
Ion-conducting ceramic apparatus, method, fabrication, and applications
A c-axis-oriented HAP thin film synthesized by seeded growth on a palladium hydrogen membrane substrate. An exemplary synthetic process includes electrochemical seeding on the substrate, and...
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US20120053175 |
MLK INHIBITORS AND METHODS OF USE
Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods...
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US20120045163 |
OPTICAL CIRCUIT APPARATUS, METHOD, AND APPLICATION
A new photonic integrated circuit in the form of an optical pulse-train generator utilizes a time-interleaved architecture. The circuit can generate multiple optical pulses sequentially from a...
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8119394 |
Cell culture devices having ultrathin porous membrane and uses thereof
Disclosed is a device for co-culturing two or more populations of cells using ultrathin, porous membranes positioned between cell culture chambers. Multiple chamber devices and uses thereof are...
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8119118 |
Helper virus-free herpesvirus amplicon particles and uses thereof
The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases...
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US20120041289 |
SYSTEM AND METHOD FOR STIMULATION OF BIOLOGIC SIGNALS IN A BIO-ELECTRO-PHYSIOLOGIC MATRIX
An implantable device for monitoring physiological changes in an organism is disclosed. The device includes a matrix positioned proximate a biological material of the organism, an irradiation...
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US20120040269 |
ION/PROTON-CONDUCTING APPARATUS AND METHOD
A c-axis-oriented HAP thin film synthesized by seeded growth on a palladium hydrogen membrane substrate. An exemplary synthetic process includes electrochemical seeding on the substrate, and...
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US20120040127 |
STACKED OPTICAL ANTENNA STRUCTURES, METHODS AND APPLICATIONS
A stacked optical antenna structure includes a stacked structure including: (1) a first antenna arm located over a substrate; (2) an interstitial gap layer located over at least a portion of the...
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US20120039798 |
METHODS OF MODIFYING P53 ACETYLATION AND TREATING CANCER USING AVRA
The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or...
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US20120025136 |
PHOTO-SWITCHABLE MEMBRANE AND METHOD
Switchable gas permeation membranes in which a photo-switchable low-molecular-weight liquid crystalline (LC) material acts as the active element, and a method of making such membranes. Different LC...
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8107710 |
Automated placental measurement
A method for analyzing the placenta and histology slides of placental tissue comprising: selecting a placental sample to be analyzed; obtaining a digital image of the placental sample; and...
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8107156 |
Digital binary MEMS wavefront control
Embodiments of the invention are directed to a new type of phase screen, i.e., an opto-electronic device that can convert a distorted incoming optical wavefront into a plane wave or, conversely,...
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US20120021986 |
PROTECTING AND REPAIRING CARTILAGE AND MUSCULOSKELETAL SOFT TISSUES
Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular...
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US20120019738 |
PCLC FLAKE-BASED APPARATUS AND METHOD
A PCLC flake/fluid host suspension that enables dual-frequency, reverse drive reorientation and relaxation of the PCLC flakes is composed of a fluid host that is a mixture of: 94 to 99.5 wt % of a...
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8103856 |
Performance monitoring for new phase dynamic optimization of instruction dispatch cluster configuration
In a processor having multiple clusters which operate in parallel, the number of clusters in use can be varied dynamically. At the start of each program phase, the configuration option for an...
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US20120015001 |
METHODS OF TREATING THYROID EYE DISEASE
The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid...
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US20120008845 |
Method and apparatus for 3d metal and high-density artifact correction for cone-beam and fan-beam ct imaging
A 3D metal artifacts correction technique corrects the streaking artifacts generated by titanium implants or other similar objects. A cone-beam computed tomography system is utilized to provide 3D...
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8092791 |
Method of producing herpes simplex virus amplicons, resulting amplicons, and their use
The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector...
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US20120003241 |
VACCINE AGAINST BOTULISM
The invention relates to novel DNA and protein vaccines against Clostridium botulinum. The DNA vaccine includes a DNA molecule that includes a first segment encoding a fragment of a heavy chain...
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US20110318376 |
RECOMBINANT EXPRESSION OF SELF-FOLDING NEUTRALIZING EPITOPE-BEARING SUBDOMAINS OF THE RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT AND FUSION PROTEINS
The present invention is directed to self-folding, soluble, stable RSV G and F polypeptides that contain a neutralizing epitope. Fusion proteins and immunogenic conjugates containing the RSV G and...
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8074598 |
Fluid management system and method for fluid dispensing and coating
A system and method are provided including a coating method and apparatus using a dielectrophoretic fluid movement system to coat with a non-conducting fluid along a surface that includes a...
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US20110300129 |
SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY
Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable...
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US20110289605 |
Animal Model for Osteoarthritis and Intervertebral Disc Disease
Provided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated...
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US20110286990 |
METHODS OF DIAGNOSING AND TREATING FIBROSIS
The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue...
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8062642 |
Production of papillomavirus capsid protein and virus-like particles
The present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the...
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US20110280859 |
PREVENTING AND TREATING SEPSIS
Provided are polypeptides comprising a variant activated protein C comprising one or more amino acid substitutions selected from the group consisting of K146R, D172N, C212R, K146G, R147G, R177G and...
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8060246 |
System and method for interactive items dispenser
A networked items dispenser is disclosed. The device includes a housing having a bulk storage bin for storing items, a temporary storage bin for receiving the items, and a dispensing receptacle for...
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US20110275532 |
USE OF NON-NUCLEOPHILIC ADDITIVES FOR REDUCTION OF SURFACE MORPHOLOGICAL ANOMALIES IN PROBE ARRAYS
The present invention relates to a formulations and methods for coupling a reactant (or probe precursor) to a functionalized surface for purposes of forming an arrayed sensor. This method includes...
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US20110268748 |
NURR-1 Interacting Protein (NuIP)
Provided herein are methods of promoting the activity of Nurr1 in a cell comprising contacting the cell with NuIP or an analog or fragment thereof. Also provided are methods of treating or...
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8044655 |
Pulse measurement apparatus and method
An embodiment of the invention is directed to a pulse measuring system that measures a characteristic of an input pulse under test, particularly the pulse shape of a single-shot, nano-second...
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