Patents and Patent Applications from University of Rochester


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9833467 Use of cyclophilin D inhibitors to treat or prevent bone disorders  
Provided herein are methods of treating or preventing a bone disorder in a subject.
US20170344776 PER-CHANNEL COLOR BARCODES FOR DISPLAYS  
A method of decoding a coherent RGB color barcode captured by a RGB camera includes: displaying a coherent RGB color barcode on the RGB display; capturing an image of the displayed barcode;...
9826949 Methods and apparatus for differential phase-contrast cone-beam CT and hybrid cone-beam CT  
A raw DPC (differential phase contrast) image of an object is acquired. The background phase distribution due to the non-uniformity of the grating system is acquired by the same process without an...
US20170333564 Novel Approach to Treatment of Hyperglycemia Using a Nanoparticle Encapsulated Peptide  
The present invention relates to compositions and methods for treating or preventing hyperglycemia and diseases associated with hyperglycemia. In certain embodiments, the composition comprises a...
US20170330617 RESISTIVE MEMORY ACCELERATOR  
Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the...
US20170327874 Methods of Diagnosing Bacterial Infections  
The present invention relates to compositions and methods useful for the assessment, diagnosis, and treatment of bacterial infections.
9815869 SP-B and SP-C peptides, synthetic lung surfactants, and use thereof  
The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol...
9814704 Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors  
Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. The compounds include substituted pyrrolo[2,3-b]pyridines having Formula IX Also provided are pharmaceutical...
9793178 Focused beam scatterometry apparatus and method  
The capacity to measure nanoscale features rapidly and accurately is of central importance for the monitoring of manufacturing processes in the production of computer integrated circuits. It is...
9785161 Heterogeneous method for energy efficient distribution of on-chip power supplies and power network on-chip system for scalable power delivery  
A heterogeneous power distribution system for an integrated circuit includes a power network-on-chip that receives electrical power from one or more off-chip power converters. The power...
US20170281710 USE OF INHIBITORS OF BINDING BETWEEN A PAR-1 RECEPTOR AND ITS LIGANDS FOR THE TREATMENT OF GLIOMA  
The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a PAR-1 receptor and...
9779706 Context-dependent piano music transcription with convolutional sparse coding  
The present disclosure presents a novel approach to automatic transcription of piano music in a context-dependent setting. Embodiments described herein may employ an efficient algorithm for...
9775515 System and method for multi-scale closed-loop eye tracking with real-time image montaging  
A system for multi-scale closed-loop eye tracking to compensate for translation and rotation motion while imaging in vivo a surface area of an internal structure of an eye of a subject includes a...
US20170266166 Compositions and Methods to Inhibit Estrogen Receptor Beta for the Treatment of Renal Cell Carcinoma  
The invention provides compositions and methods for treating and preventing cancer. The invention relates to compositions and methods for treating subjects having a cancer associated with...
9765338 Modulation of dystrophia myotonica-protein kinase (DMPK) expression  
Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for...
US20170264068 EFFICIENT LASING WITH EXCITED-STATE ABSORPTION-IMPAIRED MATERIALS  
Laser signal intensity is resonantly enhanced within a laser cavity to be greater than a pump intensity. This enables the suppression of excited-state absorption and is applicable to terbium-doped...
US20170260504 ULTRASOUND TECHNOLOGY TO CONTROL THE SPATIAL ORGANIZATION OF CELLS AND PROTEINS IN ENGINEERED TISSUES  
The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of...
9758572 Anti-glucosaminidase passive immunization for Staphylococcus aureus infections  
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are...
9757428 Designed peptides for tight junction barrier modulation  
According to aspects illustrated herein, there is provided an agent that transiently disrupts claudin-1 within tight junctions. The agent includes a peptide having at least 40% polar, uncharged...
9753349 Optical circuit apparatus, method, and application  
A new photonic integrated circuit in the form of an optical pulse-train generator utilizes a time-interleaved architecture. The circuit can generate multiple optical pulses sequentially from a...
9750761 LDH inhibitors as treatment for fibrosis and fibrotic-related disorders  
One aspect of the disclosure relates to methods of treating a fibrotic condition in an individual. The methods include administering to an individual having a fibrotic condition an effective...
9750749 Methods of treating thyroid eye disease  
The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid...
US20170248491 DIAGNOSTIC FOR RESOLUTION-ENHANCED TEMPORAL MEASUREMENT OF SHORT OPTICAL PULSES  
The disclosure relates to the measurement of temporal characteristics of optical pulses. Embodiments may be used for single-shot characterization of picosecond optical pulses. The optical pulse...
US20170246139 SYNERGISTIC COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS  
Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein...
US20170243571 CONTEXT-DEPENDENT PIANO MUSIC TRANSCRIPTION WITH CONVOLUTIONAL SPARSE CODING  
The present disclosure presents a novel approach to automatic transcription of piano music in a context-dependent setting. Embodiments described herein may employ an efficient algorithm for...
US20170239322 COMPOSITIONS AND METHODS FOR ENHANCING CARDIAC FUNCTION IN THE NEONATE  
The invention provides novel pharmaceutical compositions and methods for treating newborns in need of enhanced cardiac function, in particular, newborns suffering from cardiomyopathy, or a related...
9737601 Anti-glucosaminidase passive immunization for Staphylococcus aureus infections  
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are...
US20170236284 REGISTRATION OF AERIAL IMAGERY TO VECTOR ROAD MAPS WITH ON-ROAD VEHICULAR DETECTION AND TRACKING  
Methods for aligning images captured by aerial imaging platforms with a road network described by geo-referenced data, including the steps of: (a) identifying locations of moving vehicles in at...
9733167 Method and device for preserving and imaging specimens while retaining information on the spatial orientation of specimens with respect to reference objects  
An object, such as a tumor from a breast lumpectomy, is placed into an object positioning device that can hold the object without deforming it. Such a device can include a container with a...
US20170226122 ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS  
Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the...
9729994 System and method for listener controlled beamforming  
A system and method for providing assistive listening for a plurality of listeners in an environment including a plurality of acoustic sources. A microphone array in combination with an acoustic...
9724432 Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder  
The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model...
US20170216332 SMALL MOLECULE ANTI-SCARRING AGENTS  
Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically...
US20170209494 TREATING MYELIN DISEASES WITH OPTIMIZED CELL PREPARATIONS  
The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
US20170206657 Enhanced Algorithm for the Detection of Eye Motion from Fundus Images  
A method, controller, and non-transitory medium for obtaining images of a moving subject. Estimating changes in position of the subject based on the images. Calculating a quality metric of the...
9709553 Treating myelin diseases with optimized cell preparations  
The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
US20170198255 INDUCED PLURIPOTENT CELL-DERIVED OLIGODENDROCYTE PROGENITOR CELLS FOR THE TREATMENT OF MYELIN DISORDERS  
The present invention relates to preparations of induced pluripotent cell-derived oligodendrocyte progenitor cells, and methods of making, isolating, and using these preparations.
US20170196964 Novel Arenavirus Vaccine  
The invention relates to compositions and methods for preventing or treating arenavirus related diseases and disorders through the administration to a subject in need thereof a live-attenuated...
US20170196449 SYSTEM AND METHOD FOR REAL-TIME MONTAGING FROM LIVE MOVING RETINA  
A scanning LASER ophthalmoscope (SLO) system for real-time montaging includes an adaptive optics scanning light ophthalmoscope (AOSLO) and a wide field scanning light ophthalmoscope (WFSLO). At...
US20170192018 METABOLIC BIOMARKERS FOR MEMORY LOSS  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the...
US20170189228 Real-Time Laser Modulation And Delivery In Ophthalmic Devices For Scanning, Imaging, And Laser Treatment Of The Eye  
Systems and methods of real-time laser control and modulation for ophthalmic devices are described. The systems and methods can be used for precise laser delivery at sub-micron resolution in both...
US20170188822 System And Method For Real-Time Eye Tracking For A Scanning Laser Ophthalmoscope  
Systems and methods for real-time eye tracking using a SLO or other imaging device are described. The systems and methods provide robust and accurate image-based eye tracking for both small and...
US20170188815 MEASUREMENT OF THE LIPID AND AQUEOUS LAYERS OF A TEAR FILM  
Systems and methods for determining thickness of lipid and aqueous layers of a tear film in which a spectrum array is generated from optical coherence tomography and input into a statistical...
9694050 THY1 (CD90) as a novel therapy to control adipose tissue accumulation  
The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis...
9693999 Small molecule RNase inhibitors and methods of use  
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing...
US20170184613 EXOSOME AND LIPID BIOMARKERS FOR MEMORY LOSS  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one sample from the subject...
US20170183733 GENETIC MARKERS FOR MEMORY LOSS  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from...
US20170182098 NON-HUMAN MAMMAL MODEL OF HUMAN DEGENERATIVE DISORDER, USES THEREOF, AND METHOD OF TREATING HUMAN DEGENERATIVE DISORDER  
The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model...
US20170182097 NON-HUMAN MAMMAL MODEL OF HUMAN DEGENERATIVE DISORDER, USES THEREOF, AND METHOD OF TREATING HUMAN DEGENERATIVE DISORDER  
The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model...
US20170181846 Optical Material and Method for Modifying the Refractive Index  
An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm....