Patents and Patent Applications from University of Rochester


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US20180173009 OPTICAL DEVICE FOR OFF-AXIS VIEWING  
An optical device for off-axis viewing includes a contact lens adapted for human eye wear. The contact lens includes a diffraction grating written into or on the contact lens. A peripheral light...
US20180171288 METHODS OF TREATING CANCER  
Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition...
US20180166593 Multiple Layer Optics for Light Collecting and Emitting Apparatus  
A light guide includes a light guide layer having a transversely oriented side-end surface that forms a primary output aperture (exit) for light traveling in a forward propagation direction out of...
US20180163209 MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION  
Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for...
9993429 Composition and methods for the treatment of peripheral nerve injury  
Provided herein are methods of treating a peripheral nerve injury in a subject. The methods include administering to the subject at or near the site of the peripheral nerve injury an effective...
9993168 Implantable pressure monitor  
There is provided an implantable pressure monitor having a fluid sack in contact with a body part of a patient where the fluid sack is retained to the body part by a pressure monitor housing that...
US20180155492 SHAPE-MEMORY POLYMERS AND METHODS OF MAKING AND USE THEREOF  
Described are shape-memory polymers that have a composite prepolymer crosslinked with a stoichiometric amount of a multifunctional crosslinker, the composite prepolymer having a branched or...
US20180153990 PCA1 PROTEIN AND METHODS OF TREATING PNEUMOCYSTIS PNEUMONIA INFECTION  
The present invention relates to a method of treating Pneumocystis pneumonia infection in a subject. This method involves administering to a subject having a Pneumocystis pneumonia infection one...
9988448 DC-STAMP antibodies  
Provided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of DC-STAMP, wherein the epitope...
US20180149665 Metabolic Biomarkers for Memory Loss  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the...
US20180143194 COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCOUS INFECTIONS  
Provided herein are compositions and methods for detecting and/or diagnosing a Staphylococcus aureus (S. aureus) infection in a subject. It is a surprising finding of the present invention that an...
US20180136039 IMAGING SPECTROMETER WITH FREEFORM SURFACES  
Expanded performance opportunities for imaging spectrometers are described using φ-polynomial freeform surfaces in reflective and diffractive optics. The imaging spectrometers are generally of a...
9970059 Survival predictor for diffuse large B cell lymphoma  
The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
US20180127468 ANTI-HIV PEPTIDES  
The present disclosure provides simple β-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use...
9964444 Imaging spectrometer design tool for evaluating freeform optics  
A full-field display for spectrally dispersive imaging optics, particularly as a design tool for evaluating optical designs including designs with freeform optical surfaces, includes a ray tracing...
US20180113310 FREEFORM NANOSTRUCTURED SURFACE FOR VIRTUAL AND AUGMENTED REALITY NEAR EYE DISPLAY  
A near eye display includes at least one of a combiner, a secondary mirror, and a waveguide having a freeform nanostructured surface. The freeform nanostructured surface encompasses a freeform...
9949950 Compositions and methods for controlled localized delivery of bone forming therapeutic agents  
The present invention provides compositions and methods for providing controllable local delivery of a therapeutic agent to promote bone formation. In certain embodiments, the invention is used as...
9943585 Methods and compositions related to reorganization of arenavirus genome for development of novel arenavirus live-attenuated vaccines (LAV)  
Disclosed are compositions and methods related to recombinant arenaviruses and their use in vaccines for the treatment or prevention of an arenavirus infection.
9939558 Method for modifying the refractive index of an optical material and resulting optical vision component  
A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond...
US20180086878 SHAPE-MEMORY POLYMERS AND METHODS OF MAKING AND USE THEREOF  
Described are shape-memory polymers that have a branched or telechelic prepolymer having a low polydispersity crosslinked with a stoichiometric amount of a multifunctional crosslinker. Also...
9925038 System and method for designing wavefront-guided ophthalmic lenses  
The design of a corrective lens combines the measured aberration with decentration and rotation of the lens to design customized optical surface profiles to reliably achieve vision correction.
9913580 Apparatus, method, and non-transitory medium for optical stabilization and digital image registration in scanning light ophthalmoscopy  
Apparatus, method, and non-transitory medium for optical stabilization and digital image registration in scanning light ophthalmoscopy. Scanning an object with measurement light. Acquire an image...
US20180068722 RESISTIVE MEMORY ACCELERATOR  
Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the...
US20180064328 Method For Imaging Retinal Structures  
A method for imaging retinal structures involves offsetting an imaging aperture from the center of the reflected/scattered light distribution. Images are obtained with the imaging aperture at...
9907853 Approach to treatment of hyperglycemia using a nanoparticle encapsulated peptide  
The present invention relates to compositions and methods for treating or preventing hyperglycemia and diseases associated with hyperglycemia. In certain embodiments, the composition comprises a...
US20180055915 COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER  
The invention provides novel therapeutically methods and pharmaceutical compositions for treating prostate cancer with increased survival rate and improved treatment outcome. Methods and...
9905008 Automated fundus image field detection and quality assessment  
A method, system, and computer readable medium which automatically determine the side, field and a level of image quality of fundus images of the retina of a human eye is disclosed. The disclosure...
9902673 Methods for producing butanol  
Methods and compositions for producing 1-butanol are described herein. In some examples, the methods can comprise, contacting a reactant comprising ethanol with a catalyst system, thereby...
9901650 Methods for evaluating brain-wide paravascular pathway for waste clearance function and methods for treating neurodegenerative disorders based thereon  
Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal...
US20180052584 3D DISPLAY RAY PRINCIPLES AND METHODS, ZOOMING, AND REAL-TIME DEMONSTRATION  
The present disclosure is generally related to three-dimensional displays and methods for displaying three-dimensional images. Some embodiments may be related to zooming for 3D image capture and...
US20180052156 A POLYMER MICROPARTICLE-BASED METHOD FOR PROBE DEPOSITION IN LABEL-FREE BIOSENSORS  
Disclosed is a sensor chip for detecting a target molecule in a sample. The sensor chip includes a substrate having a surface and a layer of hydrogel particles immobilized on the substrate surface...
US20180050127 Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients  
The present disclosure is directed to blood dotting compositions comprising platelet microparticles, method of using said compositions, and methods of preparing the same.
9899212 Methods for depositing a monolayer on a substrate  
Methods and compositions for depositing a monolayer onto a surface of a substrate are described. The method can include contacting the surface with a vapor phase comprising a carbene source, and...
US20180044406 ANTI-GLUCOSAMINIDASE PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS AUREUS INFECTIONS  
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are...
US20180043021 ANTI-GLUCOSAMINIDASE PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS AUREUS INFECTIONS  
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are...
9878032 Attenuated influenza vaccines and uses thereof  
Provided herein are attenuated influenza viruses and methods of making attenuated influenza viruses.
US20180021172 APPARATUS AND METHOD FOR ENHANCING CORNEAL LENTICULAR SURGERY WITH LASER REFRACTIVE INDEX CHANGES  
Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical tissues is performed in combination with corneal lenticular surgery to achieve...
9875541 Enhanced algorithm for the detection of eye motion from fundus images  
A method, controller, and non-transitory medium for obtaining images of a moving subject. Estimating changes in position of the subject based on the images. Calculating a quality metric of the...
9873000 Low intensity magnetic field devices for treatment of cardiac and neurological disorders  
There is provided a medical device comprising a low intensity electromagnetic field source to increase the respiratory control index values (RCI) of mitochondria. The medical device may be...
US20180014771 SYSTEM AND METHOD TO ASSESS RISK OF CHANGES TO BRAIN WHITE MATTER BASED ON HEAD IMPACT DOSE EQUIVALENT NUMBER  
A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a...
US20180011106 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS  
Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate...
US20170363725 ULTRASOUND SYSTEM FOR HIGH-SPEED AND HIGH RESOLUTION IMAGING APPLICATIONS  
An ultrasound imaging system includes an array of ultrasound transducer elements chat send ultrasound energy into an object when energized for respective transmission time periods and provide...
9847125 Resistive memory accelerator  
Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the...
9844320 System and method for observing an object in a blood vessel  
A method for creating a virtual 2D image of an object moving in a blood vessel includes the steps of: providing an imaging apparatus capable of acquiring 1D images. The imaging apparatus is...
9833467 Use of cyclophilin D inhibitors to treat or prevent bone disorders  
Provided herein are methods of treating or preventing a bone disorder in a subject.
US20170344776 PER-CHANNEL COLOR BARCODES FOR DISPLAYS  
A method of decoding a coherent RGB color barcode captured by a RGB camera includes: displaying a coherent RGB color barcode on the RGB display; capturing an image of the displayed barcode;...
9826949 Methods and apparatus for differential phase-contrast cone-beam CT and hybrid cone-beam CT  
A raw DPC (differential phase contrast) image of an object is acquired. The background phase distribution due to the non-uniformity of the grating system is acquired by the same process without an...
US20170333564 Novel Approach to Treatment of Hyperglycemia Using a Nanoparticle Encapsulated Peptide  
The present invention relates to compositions and methods for treating or preventing hyperglycemia and diseases associated with hyperglycemia. In certain embodiments, the composition comprises a...
US20170330617 RESISTIVE MEMORY ACCELERATOR  
Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the...
US20170327874 Methods of Diagnosing Bacterial Infections  
The present invention relates to compositions and methods useful for the assessment, diagnosis, and treatment of bacterial infections.