Patents and Patent Applications from University of Rhode Island


Matches 1 - 50 out of 68 1 2 >
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9833446 Hedgehog pathway inhibition for cartilage tumor and metachondromatosis treatment  
A method for preventing, slowing, or blocking the formation of an exostosis or an enchondromas comprising administering to an animal in need thereof a hedgehog pathway inhibitor such as a...
9814781 Environmentally sensitive compositions and methods of use thereof  
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
9771554 Device and method for engineering living tissues  
A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement...
9771356 Inhibitors of beta-hydroxylase for treatment of cancer  
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel...
9750693 Liposome structures and methods of use thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the...
US20170182165 THERMAL ACCELERANT COMPOSITIONS AND METHODS OF USE  
A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may...
9676823 Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide  
A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a...
9675783 Intracranial fixation device  
A fixation device including a base structure such as a faceplate having an inferior surface capable of contacting a surface of a skull of a patient, having a superior surface, and defining at...
9616116 Detoxified endotoxin immunogenic compositions and uses thereof  
The present invention provides an immunogenic composition of a lipopolysaccharide vaccine and a non-alum adjuvant. The immunogenic composition may be detoxified J5 core lipopolysaccharide of...
US20170029397 METHODS FOR SKING WHITENING USING A GALLOTANNIN  
A method is disclosed for synthesizing a compound that includes gallotannins from a part of a maple tree, into new skin whitening compounds. The method includes the step of isolating the...
US20160303775 METHOD FOR HIGHLY CONDUCTIVE GRAPHENE-BASED SEGREGATED COMPOSITES  
A method is disclosed of dispersing conductive particles within a polymer. The method includes the steps of providing dry polymer particles, adding conductive material to the dry polymer particles...
US20160274086 Methods compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging  
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues....
US20160256560 Environmentally Sensitive Compositions  
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
9355813 Microfluidic blotless cryo TEM device and method  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
US20160139149 CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS  
Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from...
9312095 Method and system for automating sample preparation for microfluidic cryo TEM  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
9289508 Environmentally sensitive compositions and methods of use in the treatment and diagnosis of tumors  
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
9281564 Systems and methods for providing directional radiation fields using distributed loaded monopole antennas  
An antenna system is disclosed that provides a directional radiation field. The antenna system includes at least two monopole antennas, each of which provides a differential connector. Each...
US20160033484 SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS  
The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum...
9220714 Nitrofuran compounds for the treatment of cancer and angiogenesis  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
US20150293129 DETECTION AND TREATMENT OF PREGNANCY COMPLICATIONS  
Disclosed herein is a method of of identifying and/or addressing incipient preeclampsia in a patient-subject by the steps of by the steps of (a) performing a bioassay to determine the level of at...
US20150265206 ACCURATE ANALYSIS TOOL AND METHOD FOR THE QUANTITATIVE ACOUSTIC ASSESSMENT OF INFANT CRY  
An automated infant cry analyzer with high accuracy to detect important acoustic features of cry is provided. The system's accuracy was rigorously tested and was compared to ground truth manual...
US20150258213 Nanotubes as Carriers of Nucleic Acids into Cells  
The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
US20150224212 FERRITIN-BASED TUMOR TARGETING AGENT, AND IMAGING AND TREATMENT METHODS  
An MRI contrast material includes tumor-targeting metal-loaded ferritin nanoparticles constructed with genetically modified ferritin coupled to a target-specific agent. Ferritin derived from...
US20150210677 Inhibitors of Beta-Hydroxylase for Treatment of Cancer  
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel...
US20150194704 ELECTROCHEMICAL CELLS  
A lithium ion battery comprising (i) at least one anode, (ii) at least one cathode containing a cathode active material selected from lithium ion containing transition metal compounds having a...
US20150191508 Selective Delivery of Molecules into Cells or Marking of Cells in Diseased Tissue Regions Using Environmentally Sensitive Transmembrane Peptide  
A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a...
9073884 Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them  
The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles...
US20150174228 Detoxified Endotoxin Immunogenic Compositions and Uses Thereof  
The present invention provides an immunogenic composition of a lipopolysaccharide vaccine and a non-alum adjuvant. The immunogenic composition may be detoxified J5 core lipopolysaccharide of...
US20150141926 Intracranial Fixation Device  
A fixation device including a base structure such as a faceplate having an inferior surface capable of contacting a surface of a skull of a patient, having a superior surface, and defining at...
US20150045363 Hedgehog Pathway Inhibition for Cartilage Tumor and Metachondromatosis Treatment  
Hedgehog pathway inhibitors, such as small molecules, are used to prevent, slow, block the formation of cartilage tumors as well as exostosis or enchondromas.
US20150024495 DEVICE AND METHOD FOR ENGINEERING LIVING TISSUES  
A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement...
US20140371193 ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS  
This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including...
US20140336259 PHENOLIC COMPOUNDS WITH ANTIOXIDANT AND ANTI-CANCER PROPERTIES, ANALOGS AND SYNTHESIS THEREOF  
The present document describes a phytochemical isolated from maple syrup and composition comprising the same. More specifically, the document describes an antioxidant phytochemical compound,...
8846081 Liposome compositions and methods of use thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the...
US20140271795 NANOFIBROUS MATERIALS AS DRUG, PROTEIN, OR GENETIC RELEASE VEHICLES  
The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite...
8771582 Electrospinning process for making a textile suitable for use as a medical article  
The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite...
US20140171482 Nanotubes as Carriers of Nucleic Acids into Cells  
The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
US20140147481 ANTI-INFLAMMATORY AND QUORUM SENSING INHIBITION COMPOUNDS AND METHODS OF MAKING AND USING THEM  
The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles...
US20140081432 Method and Apparatus for Rehabilitation Using Adapted Video Games  
A participant, engages in healthcare provider prescribed physical rehabilitation exercises utilizing specifically designed controllers, and these exercises are mapped to one or more video game...
US20130331383 NITROFURAN COMPOUNDS FOR THE TREATMENT OF CANCER AND ANGIOGENESIS  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
US20130310332 MAPLE TREE-DERIVED PRODUCTS AND USES THEREOF  
The present document describes a neutraceutical, cosmeceuticals, functional food, pharmaceutical, food ingredient, and non-food ingredient compositions comprising sugar maple extract, essential...
US20130267474 NOVEL PHYTOCHEMICALS FROM EXTRACTS OF MAPLE SYRUPS AND MAPLE TREES AND USES THEREOF  
The present invention describes phytochemicals present in maple syrup and maple tree extracts by butanol, ethyl acetate and methanol. Novel compounds are isolated from maple syrups, including one...
8470815 Nitrofuran compounds for the treatment of cancer and angiogenesis  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
US20130024985 MALE AND FEMALE STERILITY LINES USED TO MAKE HYBRIDS IN GENETICALLY MODIFIED PLANTS  
A method is disclosed for producing a hybrid perennial plant system for plant breeding of co-sexual plants for increased yields and for having increased gene confinement capabilities. The method...
US20130023511 ORGANOMETALLIC COMPLEXES AS THERAPEUTIC AGENTS  
This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including...
8252780 Organometallic complexes as therapeutic agents  
This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including...
8076451 Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide  
A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a...
US20110288080 Nitrofuran Compounds for the Treatment of Cancer and Angiogenesis  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
US20110210900 SYSTEMS AND METHODS FOR PROVIDING DIRECTIONAL RADIATION FIELDS USING DISTRIBUTED LOADED MONOPOLE ANTENNAS  
An antenna system is disclosed that provides a directional radiation field. The antenna system includes at least two monopole antennas, each of which provides a differential connector. Each...
Matches 1 - 50 out of 68 1 2 >