Patents and Patent Applications from University of Pittsburgh


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US20170354762 IMPLANTABLE MEDICAL DEVICES HAVING DOUBLE WALLED MICROSPHERES  
An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
9840515 Protein kinase D inhibitors  
Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription,...
9833458 Thioflavin derivatives for use in the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
9833226 Endoscopic ports for minimally invasive surgical access and methods of use thereof  
A method for providing an endoscopic port includes inserting a distal portion of an expandable member into soft tissue in a patient's body. The distal portion of the expandable member is inflated...
US20170343543 DEGRADABLE CARBON NANOTUBE-CONTAINING BIOSENSORS AND METHODS FOR TARGET CLINICAL MARKER DETECTION  
The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The...
US20170343536 MULTIPARAMETRIC METHOD FOR ASSESSING IMMUNE SYSTEM STATUS  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
US20170342498 PARP GENOMIC VARIANTS CONFERRING RESISTANCE AND SENSITIZATION TO CHEMOTHERAPY UNDER INHIBITION  
A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating...
US20170342120 USE OF RELAXIN TO TREAT ATRIAL FIBRILLATION  
Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
US20170340463 SUPER ELASTIC, BIOABSORBABLE ENDOVASCULAR DEVICES  
The invention relates to endovascular medical implant devices and materials of composition for forming these devices to provide improved mechanical properties and biodegradability. The devices...
US20170340432 Bioerodible Wraps and Uses Therefor  
A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
US20170337962 ADAPTIVE REFRESHING AND READ VOLTAGE CONTROL SCHEME FOR A MEMORY DEVICE SUCH AS AN FeDRAM  
A memory device, such as an FeDRAM device, includes a memory array including a plurality of rows, each row having a plurality of storage elements (e.g., FeFETs). The memory device further includes...
US20170337848 MYRINGOTOMY SURGICAL TRAINING DEVICE WITH REAL-TIME AND STORED FEEDBACK ON PERFORMANCE  
A system for performing a myringotomy training procedure placing a tympanostomy tube in a simulated ear drum of a patient includes a canal structure. The canal structure includes a tubular portion...
US20170336411 B-CELL ANTIGEN PRESENTING CELL ASSAY  
Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting...
US20170335382 Isothermal Amplification Assay for the Detection of Short Nucleic Acid Sequences  
Provided herein is a method of detecting short nucleic acids, such as microRNAs, in a sample, such as urine, and a kit for use in detection of the short nucleic acids.
US20170333488 STEM CELL-BASED TECHNOLOGIES FOR AVIAN SKELETAL TISSUE ENGINEERING AND REGENERATION  
Methods are disclosed for forming bone and/or cartilage in an avian subject. The methods include administering to the avian subject a therapeutically effective amount of a composition comprising...
9822371 E. coli separatome-based protein expression and purification platform  
Provided is a separatome-based peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides,...
9820990 Methods of treating disorders associated with protein aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
US20170326381 WIRELESS MICRO/NANO- STIMULATION OPTO-ELECTRODE FOR EXCITABLE TISSUE  
Disclosed are wireless stimulation electrode for excitable tissue. In one example, a wireless stimulation electrode includes a body made of biocompatible photovoltaic and/or photothermal material;...
9816068 Separatome-based protein expression and purification platform  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
9814821 Devices, systems and methods for reducing the concentration of carbon dioxide in blood  
A method for removal of at least a portion of carbon dioxide from an aqueous fluid such as a blood fluid includes placing a first surface of at least one membrane through which carbon dioxide and...
9814744 Decellularized adipose cell growth scaffold  
Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
US20170322201 ANTIGEN PRESENTING CELL ASSAY  
Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first...
US20170321113 PROPPANTS FOR HYDROCARBON RECOVERY  
A method of sequestering at least one target species, including exposing a proppant for use in subterranean hydrocarbon recovery via hydraulic fracturing which comprises a material adapted to...
US20170320898 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury  
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use...
9808560 Biodegradable, non-thrombogenic elastomeric polyurethanes  
A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the...
9808541 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
US20170312315 Engineered Dendritic Cells and Uses for the Treatment of Cancer  
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12...
9801928 Monoclonal antibodies for CSPG4 for the diagnosis and treatment of basal breast carcinoma  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20170304499 INJECTABLE PERIPHERAL NERVE SPECIFIC HYDROGEL  
The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following...
9799096 System and method for processing video to provide facial de-identification  
A system and method for real-time image and video face de-identification that removes the identity of the subject while preserving the facial behavior is described The facial features of the...
9796714 Calcium channel agonists  
Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms...
9796681 Tetrahydroisoquinolines as selective NADPH oxidase 2 inhibitors  
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed...
US20170298517 SYNTHESIS OF STRUCTURED CARBON MATERIAL FROM ORGANIC MATERIALS  
A method of forming a carbonized composition includes providing an organic composition, forming a protective layer over the organic composition, increasing temperature to carbonize the organic...
US20170297008 CU(I)-CATALYZED AZIDE-ALKYNE CYCLOADDITIONS (CUAAC) LIGANDS AND METHODS FOR CARRYING OUT CU(I)-CATALYZED AZIDE-ALKYNE CYCLOADDITION REACTIONS  
A Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core. A method for carrying out a...
9790167 Vinyl substituted fatty acids  
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated...
US20170290917 ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY  
A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition;assessing degradation effect...
US20170290815 GLUTAMINASE INHIBITORS  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A is a ring; Y1 and Y2 are each independently N or C with the proper valency;X1 and X2 are each...
US20170290773 SPHINGOMYELIN LIPOSOMES FOR THE TREATMENT OF HYPERACTIVE BLADDER DISORDERS  
The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to...
9784725 Light refraction imaging to measure liquid volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
US20170283782 TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY  
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The...
9777122 Thickening compositions, and related materials and processes  
A silicone polymer is provided, modified with at least one functional group from the class of anthraquinone amide groups; anthraquinone sulfonamide groups; thioxanthone amide groups; or...
US20170274025 ONCOLYTIC HSV VECTOR  
The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more...
9772326 Multiparametric method for assessing immune system status  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
9771377 Synthesis of FR901464 and analogs with antitumor activity  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
9770481 Inhibitors of NOX1  
The present invention relates to inhibitors of Nox1-dependent reactive oxygen species production and their use in the treatment of disorders associated with reactive oxygen species, such as...
US20170267556 MANAGING NATURALLY OCCURRING RADIOACTIVE MATERIAL IN WASTEWATER  
A method of treating wastewater including calcium ions and radium ions includes charging the wastewater into a container via an inlet in the container, precipitating a portion of the calcium ions...
US20170266352 LAYER BY LAYER COATED MESH FOR LOCAL RELEASE OF BIO-ACTIVE PROTEINS  
The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or...
US20170266346 ULTRAHIGH DUCTILITY, NOVEL Mg-Li BASED ALLOYS FOR BIOMEDICAL APPLICATIONS  
The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the...
9763975 Rheological treatment of brain ischemia by drag reducing polymers  
Methods and compositions for the treatment of acute or chronic cerebral ischemia by delivery of linear, blood soluble, non-toxic macromolecules.
US20170260507 ACTIVE CXCR4+ IMMUNE CELLS AND METHODS FOR THEIR PRODUCTION AND USE  
Provided herein are active CXCR4+ CD8+ T cells, active CXCR4+ type-1 CD4+ T cells and active CXCR4+ NK cells and populations of those cells, methods for making active CXCR4+ T cells and NK cells...