Patents and Patent Applications from University of Pittsburgh


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US20170290917 ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY  
A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition;assessing degradation effect...
US20170290815 GLUTAMINASE INHIBITORS  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A is a ring; Y1 and Y2 are each independently N or C with the proper valency;X1 and X2 are each...
US20170290773 SPHINGOMYELIN LIPOSOMES FOR THE TREATMENT OF HYPERACTIVE BLADDER DISORDERS  
The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to...
9784725 Light refraction imaging to measure liquid volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
US20170283782 TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY  
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The...
9777122 Thickening compositions, and related materials and processes  
A silicone polymer is provided, modified with at least one functional group from the class of anthraquinone amide groups; anthraquinone sulfonamide groups; thioxanthone amide groups; or...
US20170274025 ONCOLYTIC HSV VECTOR  
The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more...
9772326 Multiparametric method for assessing immune system status  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
9771377 Synthesis of FR901464 and analogs with antitumor activity  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
9770481 Inhibitors of NOX1  
The present invention relates to inhibitors of Nox1-dependent reactive oxygen species production and their use in the treatment of disorders associated with reactive oxygen species, such as...
US20170267556 MANAGING NATURALLY OCCURRING RADIOACTIVE MATERIAL IN WASTEWATER  
A method of treating wastewater including calcium ions and radium ions includes charging the wastewater into a container via an inlet in the container, precipitating a portion of the calcium ions...
US20170266352 LAYER BY LAYER COATED MESH FOR LOCAL RELEASE OF BIO-ACTIVE PROTEINS  
The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or...
US20170266346 ULTRAHIGH DUCTILITY, NOVEL Mg-Li BASED ALLOYS FOR BIOMEDICAL APPLICATIONS  
The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the...
9763975 Rheological treatment of brain ischemia by drag reducing polymers  
Methods and compositions for the treatment of acute or chronic cerebral ischemia by delivery of linear, blood soluble, non-toxic macromolecules.
US20170260507 ACTIVE CXCR4+ IMMUNE CELLS AND METHODS FOR THEIR PRODUCTION AND USE  
Provided herein are active CXCR4+ CD8+ T cells, active CXCR4+ type-1 CD4+ T cells and active CXCR4+ NK cells and populations of those cells, methods for making active CXCR4+ T cells and NK cells...
9759723 B-cell antigen presenting cell assay  
Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting...
9757339 Artificial cell constructs for cellular manipulation  
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20170254800 MULTIPARAMETRIC METHOD FOR ASSESSING IMMUNE SYSTEM STATUS  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
US20170253854 Use of Adipose-Derived Stem Cells for Glaucoma Treatment  
A method of preparing a functional trabecular meshwork (TM) cell from adipose-derived stem cells is provided. Methods of treating glaucoma, implanting trabecular meshwork (TM) cells, or repairing...
US20170252485 OVARIAN-DERIVED HYDROGELS FOR BIOMEDICAL AND BIOTECHNOLOGY APPLICATIONS  
The present invention relates to an ovarian-derived hydrogel material, which can be useful for three-dimensional in vitro culturing of cells, cell therapy, fertility preservation, drug delivery,...
9753030 Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection  
The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The...
9750851 Implantable medical devices having double walled microspheres  
An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
9750725 Fatty acids as anti-inflammatory agents  
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In particular,...
US20170251145 PASSIVELY POWERED IMAGE CAPTURE AND TRANSMISSION SYSTEM  
A passively powered image capture device includes a remote execution unit structured to receive commands from a base station and an imaging device coupled to the remote execution unit. The imaging...
US20170247382 SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER  
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a...
US20170246350 "Bioengineered Human Corneal Stromal Tissue"  
Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct...
US20170246164 SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER  
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a...
US20170245936 SENSOR GUIDED CATHETER NAVIGATION SYSTEM  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
9746459 Antigen presenting cell assay  
Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first...
9745508 Proppants for sequestering a target species and methods of sequestering a target species in a subterranean formation  
A method of hydraulic fracturing in a subterranean formation includes injecting a fluid including a proppant into the subterranean formation, wherein the proppant includes a material adapted to...
9744267 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
US20170240924 METHODS FOR TREATING CELLS CONTAINING FUSION GENES  
The present invention relates to methods for treating prostate cancer patients. It is based, at least in part, on the discovery that approximately 90% of men carrying at least one of the following...
US20170240594 Therapeutic Use of Peptide Inhibitors of NADPH Oxidase; Aerosolization as a Delivery Mechanism  
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit...
US20170239398 MAGNESIUM ENHANCED/INDUCED BONE FORMATION  
The invention relates to a biodegradable, magnesium-containing bone screw for implanting into a patient body for use in medical applications, such as, orthopedic and craniofacial surgery. The bone...
US20170239200 SMALL MOLECULE INHIBITORS OF RNA BINDING MOTIF (RBM) PROTEINS FOR THE TREATMENT OF ACUTE CELLULAR INJURY  
A method of treating a cellular injury in a subject comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula I: wherein at least one of...
9737635 Injectable peripheral nerve specific hydrogel  
The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following...
US20170233879 NON-NOBLE METAL BASED ELECTRO-CATALYST COMPOSITIONS FOR PROTON EXCHANGE MEMBRANE BASED WATER ELECTROLYSIS AND METHODS OF MAKING  
The invention provides electro-catalyst compositions for an anode electrode of an acid mediated proton exchange membrane-based water electrolysis system. The compositions include a noble metal...
9733326 Selective zero-quantum coherence transfer (Sel-ZQC) method for metabolite imaging in a poorly shimmed magnet field without susceptibility artifact  
Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing...
9732105 Targeted nitroxide agents  
A compound having a structure of:
9731014 Use of SLURP1 as an imunomodulatory molecule in the ocular surface  
Methods for treating inflammation are disclosed, such as for treating ocular inflammation. In some embodiments, the ocular inflammation is inflammation of an ocular surface, such as keratitis. The...
US20170229724 SYSTEM AND METHOD FOR MONITORING A REACTOR SYSTEM USING OPTICAL FIBER BASED SENSORS  
A method of monitoring operation of a reactor system includes causing a chemical reaction to occur within an assembly of the reactor system, and measuring a chemical composition of one or more...
US20170226074 ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl;X is —S—, —S(O)—, or S(O)2—;R20 and...
US20170224686 TARGETING CYB5R3  
A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, or a pharmaceutically...
9724386 Use of osteoprotegerin (OPG) to increase human pancreatic beta cell survival and proliferation  
It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an...
9724365 Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies  
The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for...
US20170219585 ACTIVATION OF MYELOID-DERIVED SUPPRESSOR CELLS AS A PREDICTOR OF PATIENT RESPONSE TO INTERFERON-A THERAPY  
The present invention relates to methods and materials for more effectively treating patients with interferon. It is based on the discovery that clinical response to interferon (IFN) therapy is...
US20170218422 SEPARATOME-BASED PROTEIN EXPRESSION AND PURIFICATION PLATFORM  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
US20170211069 USE OF THE CHROMOSOME 19 MICRORNA CLUSTER (C19MC) FOR TREATING MICROBIAL DISEASE AND PROMOTING AUTHOPHAGY  
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental...
US20170210975 COMPOSITIONS FOR, SOLUTIONS FOR, AND METHODS OF USE OF SILOXANE BASED AROMATIC TRISUREAS AS VISCOSIFIERS  
A compound represented by the following formula is provided: Also provided is a solution including a compound disclosed herein, a volume of dense carbon dioxide (CO2), and a co-solvent, where the...
US20170209495 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF  
The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following...