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8445261 |
Apparatus for holding cells
An apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired...
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US20130118904 |
SEPARATION OF PARTICLES USING MULTIPLEXED DIELECTROPHORESIS
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. Time-multiplexed dielectrophoresis can be employed by cycling between two...
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8442630 |
Automated assessment of atrioventricular and ventriculoatrial conduction
A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An...
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8440993 |
Ultrahigh density patterning of conducting media
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
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8440992 |
Ultrahigh density patterning of conducting media
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
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8435948 |
Methods for inhibiting osteoclastic bone resorption and bone loss comprising administration of an anti-FSH or anti-FSHR antibody
The invention discloses compositions and methods for decreasing osteoclast which are useful for the treatment of a variety of bone loss disorders.
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US20130102662 |
USE OF INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS AND NITRIC OXIDE SCAVENGERS TO INHIBIT POST-TRAUMATIC IMMUNODEPRESSION
The present invention relates to methods and compositions that inhibit the effects of nitric oxide for inhibiting post-traumatic immunodepression. It is based, at least in part, on the discovery...
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US20130102626 |
TARGETED NITROXIDE AGENTS
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
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US20130101676 |
BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
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8426146 |
Multiparameteric method for assessing immune system status
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
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8425583 |
Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
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US20130096186 |
IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR RETARGETING TO NOVEL NON-HSV RECEPTORS
The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV vectors of the present invention can...
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US20130095566 |
Flux Balance Analysis With Molecular Crowding
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
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US20130095516 |
Light Refraction Imaging to Measure Liquid Volume
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
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8421274 |
Wireless energy transfer system
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load....
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US20130090516 |
Local Anesthesia By Magnet-Directed Concentration of Nanoparticle Conjugated Anesthetic
Methods and formulations for induction of local anesthetic effects employing magnetic nanoparticles conjugated to anesthetic molecules. Magnetic nanoparticle-local anesthetic conjugates may be...
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US20130085511 |
Novel Tactile Feedback System for Robotic Surgery
Apparatuses and methods for the haptic sensation of forces at a remote location. Groups of MEMS-based pressure sensors are combined into sensor arrays. In some embodiments, the pressure sensors are...
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US20130077046 |
NORMALIZATION OF RETINAL NERVE FIBER LAYER THICKNESS MEASUREMENTS MADE BY TIME DOMAIN-OPTICAL COHERENCE TOMOGRAPHY
A scan location matching (SLM) method identifies conventional time domain optical coherence tomography (TD-OCT) circle scan locations within three-dimensional spectral domain OCT scan volumes. A...
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8404213 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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US20130072790 |
SELECTION AND OPTIMIZATION FOR CARDIAC RESYNCHRONIZATION THERAPY
Systems and methods for imaging and analyzing a patient heart are described. Imaging can be performed with a variety or combination of methods, including single photon emission computed tomography,...
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US20130072547 |
USE OF TOLL-LIKE RECEPTOR-9 AGONISTS, TOLL-LIKE RECEPTOR-4 ANTAGONISTS, AND/OR NUCLEAR OLIGOMERIZATION DOMAIN-2 AGONISTS FOR THE TREATMENT OF PREVENTION OF TOLL-LIKE RECEPTOR-4-ASSOCIATED DISORDERS
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis...
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US20130071930 |
POLYESTERS, METHODS OF MAKING POLYESTERS AND USES THEREFOR
Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue...
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US20130071419 |
UNIVERSAL DENGUE VIRUS SEQUENCES AND METHODS OF USE
Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments (such...
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8398576 |
Removal of contrast agents from blood
The invention provides a system and a method for removal of contrast from blood. In one aspect, the invention provides a catheter for removal of contrast from the veins that drain the cerebral...
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US20130059912 |
NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its m...
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US20130058991 |
MATRICRYPTIC ECM PEPTIDES FOR TISSUE RECONSTRUCTION
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in...
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8391375 |
Wireless autonomous device data transmission
A method of communicating information from a wireless autonomous device (WAD) to a base station. The WAD has a data element having a predetermined profile having a total number of sequenced...
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8389493 |
Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
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US20130053319 |
CHEMOKINE DERIVED PEPTIDES AND USES FOR CHRONIC WOUND AND ANGIOGENESIS INHIBITION TREATMENTS
Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of...
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US20130048950 |
ON-DEMAND NANOELECTRONICS PLATFORM
A reconfigurable device includes a first insulating layer, a second insulating layer, and a nanoscale quasi one- or zero-dimensional electron gas region disposed at an interface between the first...
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US20130045164 |
AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
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8376463 |
User adjustable wheelchair backrest mounting hardware
Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of...
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8367069 |
Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid,...
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8361802 |
Fluorescent ozone sensor
A selective, fluorescent “turn-on” probe and method for the detection of ozone in biological and atmospheric samples, wherein the method of detecting ozone in a sample comprises the steps of (1)...
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8361503 |
Extracellular matrix-derived gels and related methods
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as...
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US20130024953 |
Methods of Treating Disorders Associated with Protein Aggregation
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
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8357669 |
Method of treatment for lymphedema comprising administering a polynucleotide encoding VEGF-D
The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
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8357364 |
Bone substitute compositions, methods of preparation and clinical applications
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
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US20130012583 |
VINYL SUBSTITUTED FATTY ACIDS
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty...
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8349410 |
Modification of surfaces with polymers
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
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US20130006322 |
NON-INVASIVE METHOD TO TREAT UROLOGICAL AND GASTROINTESTINAL DISORDERS
Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary...
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US20130004422 |
BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
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8343457 |
Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or...
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US20120330437 |
BIOERODIBLE WRAPS AND USES THEREFOR
A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
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US20120329834 |
COMPOUNDS FOR THE TREATMENT OF MITOCHONDRIAL DISEASES
The present invention relates to the use of compounds of general formula (I): (I) for the preparation of medicaments that act against mitochondrial pathologies involving a deficiency in ATP...
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US20120328684 |
CITROBACTER FREUNDII ANTIBACTERIAL AGENTS AND THEIR USE
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
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US20120316100 |
Therapeutic Use of Peptide Inhibitors of NADPH Oxidase; Aerosolization as a Delivery Mechanism
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit...
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8327709 |
Method and apparatus for nondestructive evaluation and monitoring of materials and structures
A method and apparatus for nondestructive evaluation (NDE) of structures and materials using a highly nonlinear medium for the generation and detection of one or multiple highly nonlinear pulses...
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8326473 |
Powered vehicle convoying systems and methods of convoying powered vehicles
A vehicle convoy system for use in connection with a vehicle, wherein the vehicle includes at least one drive mechanism to impart drive to the vehicle, includes at least a first processor that is...
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8324277 |
Nitrated-fatty acids modulation of type II diabetes
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its m...
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