Patents and Patent Applications from University of Pittsburgh


Match Document Document Title
US20180204085 SYSTEMS AND METHODS FOR FINDING REGIONS OF INTEREST IN HEMATOXYLIN AND EOSIN (H&E) STAINED TISSUE IMAGES AND QUANTIFYING INTRATUMOR CELLULAR SPATIAL HETEROGENEITY IN MULTIPLEXED/HYPERPLEXED FLUORESCENCE TISSUE IMAGES  
Graph-theoretic segmentation methods for segmenting histological structures in H&E stained images of tissues. The method relies on characterizing local spatial statistics in the images. Also, a...
US20180200405 METHODS OF PREPARING ECM SCAFFOLDS AND HYDROGELS FROM COLON  
Provided herein is a method for producing decellularized colonic extracellular matrix material. A decellularized colonic extracellular matrix material also is provided, along with uses for the...
10022438 Method of enhancing KSHV LANA1 immunogenicity  
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LANA1...
US20180192991 SENSOR GUIDED CATHETER NAVIGATION SYSTEM  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
10017544 Computationally optimized broadly reactive antigens for H1N1 influenza  
Generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates are described. The optimized HA polypeptides were developed...
US20180187268 FUSION GENES ASSOCIATED WITH PROGRESSIVE PROSTATE CANCER  
The present invention relates to methods and compositions for determining whether a subject having prostate cancer is at greater risk of developing progressive disease, and methods of treating the...
US20180185567 EXTRACORPOREAL AMBULATORY ASSIST LUNG  
An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid...
US20180185322 COMPOUNDS FOR BONE HEALING  
Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound disclosed here. The method may further...
US20180185131 BIODEGRADABLE VASCULAR GRAFTS  
A vascular graft, comprising a biodegradable scaffold comprising: a biodegradable polyester electrospun tubular core;a biodegradable polyester outer sheath surrounding the biodegradable polyester...
10011916 Superhydrophobic anodized metals and method of making same  
Methods for producing a superhydrophobic anodized surface including anodizing a surface of a substrate in an anodization acid to form a plurality of pores, etching the surface with an etchant to...
10011765 Method of sequestering a target species using a proppant  
A method of sequestering at least one target species, including exposing a proppant for use in subterranean hydrocarbon recovery via hydraulic fracturing which comprises a material adapted to...
US20180177868 COMPOSITIONS FOR MODULATING AN XBP1 PATHWAY IN A KERATINOCYTE AND METHODS OF USE  
Provided herein are compositions and methods for increasing an immune response in a subject, immunizing a subject and/or treating a disease in a subject that relate to keratinocytes. It is a...
10006896 Method, apparatus and system for food intake and physical activity assessment  
Electronic systems, devices and methods are provided to accurately record and analyze food intake and physical activity in a subject. A device is provided to be placed on a subject which records...
10004827 Extracellular matrix-derived gels and related methods  
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as...
10004766 Trabecular meshwork stem cells  
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and...
10004764 Red blood cell membrane-derived microparticles and their use for the treatment of lung disease  
Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis,...
10004730 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer  
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a...
US20180175441 CATHODES AND ELECTROLYTES FOR RECHARGEABLE MAGNESIUM BATTERIES AND METHODS OF MANUFACTURE  
The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g.,...
US20180171286 Peptide Conjugated Hydrogel Substrate for the Maintenance and Expansion of Human Pluripotent Stem Cells  
Compositions useful for propagation of pluripotent stem cells are provided. The compositions comprise a polysaccharide hydrogel linked to a peptide fragment of the extracellular domain of...
US20180170895 Mitochondria-Targeted Lapachone Compounds and Uses Therefor  
Compounds, compositions and methods useful for treating cancer and neiirodegeneration are provided. The compounds comprise a mitochondria-targeting moiety linked to β-lapachone or a β-lapachone...
US20180169754 SINGLE-HELICAL GOLD NANOPARTICLE SUPERSTRUCTURES AND METHODS OF MAKING  
Described herein are metal nanoparticle superstructures and methods and compounds for making the same.
US20180169098 SMALL MOLECULES TARGETING HIV-1 NEF  
A method of treating HIV in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound having a general Formula 1, or a pharmaceutically...
10000755 Use of the chromosome 19 microRNA cluster (C19MC) for treating microbial disease and promoting authophagy  
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental...
9999707 Method for decellularization of tissue  
Methods of decellularization of tissue, such as mammalian tissue, through use of cyclical pressure changes are provided, along with methods of making an extracellular matrix (ECM) preparation.
US20180161441 STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES  
An agent comprising: an algin crosslinked with acetal linkages; andat least one cation coupled to the crosslinked algin.
9998130 Method to perform convolutions between arbitrary vectors using clusters of weakly coupled oscillators  
A method to perform convolutions between arbitrary vectors includes estimating a first degree of match for a difference between a first vector having a plurality of first elements and a second...
US20180158182 IMAGE ENHANCEMENT USING VIRTUAL AVERAGING  
The present invention is directed to systems and methods for generating virtually averaged optical coherence tomography (OCT) images. An illustrative method can include receiving an image,...
US20180153824 TREATMENT OF ACUTE COMPLICATIONS OF SICKLE CELL DISEASE  
The invention provides pharmaceutical compositions and dosage forms of fluorocarbon nanoemulsions that are useful for treating sickle cell disease and related diseases and conditions, as well as...
9987257 Pediatric oral suspension formulations of amoxicillin and clavulanate potassium and method for using same  
The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is present in an amount equal to or less than...
9985197 Flexible molecular piezoelectric device  
A piezoelectric material, comprising: a piezoelectric self-assembling monolayer of oligopeptides; a conductive surface; and a substrate, wherein the conductive surface is located between the...
9983399 Depth-resolved spatial-domain low-coherence quantitative phase microscopy for unstained tissue and cells  
Provided are systems, methods, and other embodiments associated with depth-resolved spatial-domain low-coherence quantitative phase microscopy for high-throughput analysis of 3D nanoscale...
9981974 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer  
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a...
9981048 Methods for the treatment and prevention of liver disease  
The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an...
9980738 Surgical tool monitoring system and methods of use  
A device for simultaneously monitoring the health of surgical drills and detecting proximity to critical structures during surgery is described herein. By using various sensors (e.g. microphones,...
9980661 Electrocardiogram reconstruction from implanted device electrograms  
A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an...
9980641 Optical coherence tomography as a rapid, accurate, non-contact method of visualizing the palisades of Vogt  
The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the...
US20180141916 NOVEL SMALL MOLECULE FIEL1 INHIBITOR IN INFLAMMATORY AND FIBROTIC LUNG INJURY  
Novel compounds are disclosed along with methods of inhibiting the TGFβ pathway and methods of treating Idiopathic Pulmonary Fibrosis (IPF) using such compounds.
US20180141902 NOVEL CANNABINOID RECEPTOR CB2 LIGAND 4-(AMINOMETHYL)-N,N-DIALKYLANILINES  
Disclosed herein are novel cannabinoid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with...
US20180141859 OPTICAL SENSOR EMPLOYING A REFRACTIVE INDEX ENGINEERED METAL OXIDE MATERIAL  
An optical sensor device includes an optical waveguide portion having a core, the core having a first refractive index, and a functional material layer coupled to the optical fiber portion, the...
US20180140969 NANO SEEDING TOOLS TO GENERATE NANOMETER SIZE CRYSTALLIZATION SEEDS  
A kit and a method for using the kit to generate nanoseeds from protein nanocrystals and aggregates is disclosed. The method comprises mixing a plurality of beads with a protein nanocrystal or...
US20180140542 Custom Designed Microbubble Contrast Agents And Techniques Of Ultrasound Delivery Optimized For Nucleic Acid Delivery To Alter Gene Expression  
The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using...
US20180140184 OPTICAL COHERENCE TOMOGRAPHY AS A RAPID, ACCURATE, NON-CONTACT METHOD OF VISUALIZING THE PALISADES OF VOGT  
The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the...
US20180134758 Stabilized STAT3 Decoy Oligonucleotides and Uses Therefor  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...
US20180134693 COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS  
A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s—NH—(CH2)t, (CH2)s—O—(CH2)t, or...
US20180133472 Non-Invasive Method to Treat Urological and Gastrointestinal Disorders  
Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency,...
9968714 Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions  
Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The...
US20180127357 (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES  
A compound, or pharmaceutically acceptable salt thereof, having a formula I of: wherein R1 is H or optionally-substituted alkyl;R2 is optionally-substituted alkyl;R3 and R4 are each independently...
US20180126586 APPARATUS AND METHOD FOR JOINING OF CARBIDE CERAMICS  
A method for joining carbide ceramic particles, comprising: forming a first mixture comprising carbide ceramic particles, preceramic polymer liquid, fine carbon particles and metal nanoparticles...
US20180125897 Decellularized Adipose Cell Growth Scaffold  
Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
US20180125806 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its...