Patents: University of Pittsburgh

Patents and Patent Applications from University of Pittsburgh

Matches 1 - 50 out of 929

Match	Document	Document Title
1	US20120130255	MEDICAL DEVICE FOR DIAGNOSING PRESSURE ULCERS Medical device or instrument for diagnosing pressure ulcers using optical reflectance spectroscopy. The device may comprise a tip and a controller. The tip is pressed against the skin of the...
2	US20120128762	Sphingomyelin Liposomes for the Treatment of Hyperactive Bladder Disorders The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to...
3	8184885	System and method for visualizing a structure of interest A system. The system includes a computing device configured for communication with an imaging system and with a display device. The computing device includes a contour modeling module. The contour...
4	US20120122992	SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
5	US20120122241	IDENTIFICATION AND MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
6	US20120115173	BIOMARKERS FOR MOTOR NEURON DISEASE The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the...
7	8173366	Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
8	US20120107338	IDENTIFICATION OF A NOVEL RETROVIRUS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Methods for producing an immune response to a benign prostatic hyperplasia (BPH) virus are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
9	8165819	Modeling wound healing Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue...
10	8165673	Devices, systems and methods for characterization of ventricular fibrillation and for treatment of ventricular fibrillation A defibrillation system for use in treatment of ventricular fibrillation includes at least one sensor to measure heart rhythm; at least one applicator to apply a defibrillation pulse to a patient;...
11	8163789	Selective and dual-action p53/MDM2/MDM4 antagonists A fragment-based strategy, involving “multicomponent reaction chemistry” (MCR), can identify novel chemotypes that disrupt the p53/MDM2 or p53/MDM4 complex employs. This approach uses high res...
12	8163481	Method of extracting chromatin fractions from intact cells Methods are provided for isolation of chromatin fractions of nucleoproteins containing histone H1, H2A, H2B, H3 and H4 proteins and/or histone H1, H2A, H2B, H3 and/or H4 proteins, from intact...
13	8162925	Robot for minimally invasive interventions Rather than trying to immobilize a living, moving organ to place the organ in the fixed frame of reference of a table-mounted robotic device, the present disclosure teaches mounting a robot in the...
14	US20120095235	THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
15	8158409	Nanoscale surface plasmonics sensor with nanofluidic control A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing...
16	8158110	Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the...
17	8148146	*WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST* Cell line The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
18	8147798	Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
19	US20120078381	HUMAN-MACHINE INTERFACE BASED ON TASK-SPECIFIC TEMPORAL POSTURAL SYNERGIES A synergy-based human-machine interface that uses low-dimensional command signals to control a high dimensional virtual, robotic or paralyzed human hand is provided. Temporal postural synergies are...
20	US20120077690	BIOMARKERS OF RENAL INJURY This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
21	US20120071115	Method of Controlling RF Transmissions to Mitigate Interference with Critical Care Medical Equipment Various methods of mitigating RF inference with one or more critical care medical devices is provided, wherein a predetermined threshold energy acceleration value is associated with the one or more...
22	8138360	Isotopically-labeled benzofuran compounds as imaging agents for amyloidogenic proteins Benzofuran compounds which contain at least one detectable label selected from the group consisting of 131I, 123I, 124I, 125I, 76Br, 75Br, 18F, 19F, 11C, 13C, 14C and 3H are provided as amyloid...
23	US20120065076	METHODS FOR THE DIAGNOSIS OF FETAL DISEASE Methods are provided for detecting an aneuploidy in a fetus. These methods can be used to detect trisomy 13, 8 or 21, amongst other aneupoloidies. In some embodiments, the methods include...
24	US20120064117	TETRAVALENT INFLUENZA VACCINE AND USE THEREOF Disclosed herein is the finding that baculovirus display of multiple influenza virus hemagglutinin (HA) proteins elicits broadly reactive immune responses against influenza. Thus provided herein...
25	8133223	Automatically retracting needle-tip electrocautery device Medical devices that useful during electrocauterization procedures. The present invention encompasses a needle-tipped electrocautery device in which the needle tip is housed within the body of the...
26	US20120052080	INTERLEUKIN-13 RECEPTOR ALPHA 2 PEPTIDE-BASED BRAIN CANCER VACCINES Provided herein are interleukin-13 receptor α2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need ...
27	US20120052059	REGULATORY B CELLS AND THEIR USE Isolated regulatory B cells are disclosed, and compositions including these isolated regulatory B cells. The isolated regulatory B cells are mammalian and express T cell immunoglobulin mucin-1...
28	US20120052016	Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...
29	8126654	Identification and monitoring of systemic lupus erythematosus A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
30	8124651	Palmarumycin based inhibitors of thioredoxin and methods of using same Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in...
31	US20120045395	MicroRNAs In Idiopathic Pulmonary Fibrosis The present invention relates to the discovery that certain microRNAs are differentially expressed in Idiopathic Pulmonary Fibrosis. The present invention provides for diagnostic methods,...
32	US20120035502	ARTICULATING LARYNGOSCOPE Articulating laryngoscope to aid in the intubation of patients by providing illumination of the oral cavity and trachea during the process having, for example, ‘fingers’ with fiber optic lights at ...
33	8112139	Skin screw electrode Electrodes providing excellent recording and physical stability. Electrodes that include a plurality of small teeth that possess a novel design shape and orientation are disclosed. The shallow and...
34	8110217	Sphingomyelin liposomes for the treatment of hyperactive bladder disorders The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to...
35	8105834	Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using same The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
36	US20120015356	CONNEXIN MUTATION DETECTION FOR LYMPHATIC VARIATION AND DISEASE Methods are provided for identifying risk of developing lymphedema, including primary and secondary edema. The methods comprise identifying the presence in a biological sample of a polymorphism in...
37	US20120010276	SCREENING AND THERAPY FOR LYMPHATIC DISORDERS INVOLVING THE FLT4 RECEPTOR TYROSINE KINASE (VEGFR-3) The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
38	US20120009194	ANTIBODIES TO ENDOPLASMIN AND THEIR USE Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies,...
39	8091790	Security for blister packs Various RFID based blister pack embodiments are provided for improving the ability to detect and prevent tampering and counterfeiting of blister packs and/or facilitating the chain of custody...
40	US20120004263	Compounds for the treatment of pathologies associated with aging and degenerative disorders The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
41	US20120003335	CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) AS A THERAPEUTIC TARGET FOR OBESITY AND TYPE TWO DIABETES The invention provides a method of controlling obesity or type two diabetes in a human. In accordance with the inventive method, the constitutive androstane receptor (CAR) is agonized within the...
42	8090414	Recharging method and apparatus The present invention provides apparatus and an associated method for remotely energizing power storage devices. Energization may preferably be effected through the use of RF energy from a base...
43	8085406	Ultrafast microscopy of surface electromagnetic fields System(s) and method(s) to probe electromagnetic fields at the surface of a solid-state material are provided. The technique combines ultrafast (e.g., less than 10 fs) optical excitation and...
44	8084627	Hydroxymethyl fluorescein derivatives for use as biological markers and dyes Hydroxymethyl fluorescein derivatives are provided. The derivatives can be easily conjugated to other molecules, and are more permeable than other fluorescein derivatives. Methods of making the...
45	US20110313167	Substituted Heterocycles as Therapeutic agents for treating cancer MDM2 and MDM4 proteins prevent apoptosis of cancer cells by negatively regulating the transcription factor p53. Compounds according to Formula I are selective antagonists of MDM2 and MDM4 proteins,...
46	8080382	Monitoring immunologic, hematologic and inflammatory diseases This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, e.g., immunologic, hematologic, vascular, or infectious diseases or conditions, by...
47	US20110298591	Methods and Apparatus for Switching A Transponder To an Active State, and Asset Management Systems Employing Same A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
48	8074191	Method and software tool for designing an integrated circuit A method of designing an integrated circuit for use in an application having standards having a plurality of primitives, wherein each of the primitives has a corresponding response. The method...
49	8071540	Virus derived antimicrobial peptides Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1)...
50	US20110295060	DEVICE AND METHOD OF USE FOR FUNCTIONAL ISOLATION OF ANIMAL OR HUMAN TISSUES A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the...

Matches 1 - 50 out of 929

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