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Patents and Patent Applications from University of Pittsburgh


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US20130045164 AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
8376463 User adjustable wheelchair backrest mounting hardware  
Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of...
US20130040397 DETECTION OF HYDROGEN SULFIDE GAS USING CARBON NANOTUBE-BASED CHEMICAL SENSORS  
A method for preparing carbon allotrope based sulfide detectors comprising first functionalizing a carbon allotrope, such as a single-walled carbon nanotubes or graphene, with a solution of a...
US20130040283 GRAPHENE COMPOSITION, METHOD OF FORMING A GRAPHENE COMPOSITION AND SENSOR SYSTEM COMPRISING A GRAPHENE COMPOSITION  
A method of forming a composition includes oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide.
8367069 Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide  
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid,...
8361802 Fluorescent ozone sensor  
A selective, fluorescent “turn-on” probe and method for the detection of ozone in biological and atmospheric samples, wherein the method of detecting ozone in a sample comprises the steps of (1)...
8361503 Extracellular matrix-derived gels and related methods  
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as...
US20130024953 Methods of Treating Disorders Associated with Protein Aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
8357669 Method of treatment for lymphedema comprising administering a polynucleotide encoding VEGF-D  
The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
8357364 Bone substitute compositions, methods of preparation and clinical applications  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
US20130012583 VINYL SUBSTITUTED FATTY ACIDS  
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty...
US20130011863 Follistatin-Like Protein-1 as a Biomarker for Sepsis  
The present invention relates to methods and kits for diagnosing systemic inflammatory response syndrome or sepsis using levels of FSTL-1.
8349410 Modification of surfaces with polymers  
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
US20130006322 NON-INVASIVE METHOD TO TREAT UROLOGICAL AND GASTROINTESTINAL DISORDERS  
Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary...
US20130004422 BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
8343457 Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or...
US20120330437 BIOERODIBLE WRAPS AND USES THEREFOR  
A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
US20120329834 COMPOUNDS FOR THE TREATMENT OF MITOCHONDRIAL DISEASES  
The present invention relates to the use of compounds of general formula (I): (I) for the preparation of medicaments that act against mitochondrial pathologies involving a deficiency in ATP...
US20120328684 CITROBACTER FREUNDII ANTIBACTERIAL AGENTS AND THEIR USE  
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
8334274 Immunomodulation of inflammatory conditions utilizing Follistatin-like Protein-1 and agents that bind thereto  
Follistatin-like protein (FSTL-1) is a secreted glycoprotein of unknown function, first isolated from mouse osteoblastic cells as a transforming growth factor-β1-inducible gene. The inventors have ...
US20120316100 Therapeutic Use of Peptide Inhibitors of NADPH Oxidase; Aerosolization as a Delivery Mechanism  
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit...
8327709 Method and apparatus for nondestructive evaluation and monitoring of materials and structures  
A method and apparatus for nondestructive evaluation (NDE) of structures and materials using a highly nonlinear medium for the generation and detection of one or multiple highly nonlinear pulses...
8326473 Powered vehicle convoying systems and methods of convoying powered vehicles  
A vehicle convoy system for use in connection with a vehicle, wherein the vehicle includes at least one drive mechanism to impart drive to the vehicle, includes at least a first processor that is...
8324277 Nitrated-fatty acids modulation of type II diabetes  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its m...
8323379 Devices, systems and methods for reducing the concentration of a chemical entity in fluids  
A method of improving the blood compatibility of a blood-contacting surface includes immobilizing carbonic anhydrase on the surface, wherein the surface exhibits carbonic anhydrase activity of at...
US20120301448 TH1-ASSOCIATED MICRORNAS AND THEIR USE FOR TUMOR IMMUNOTHERAPY  
Described herein is the identification of miRNAs (miRs) that are up-regulated in Th1 cells compared to Th2 cells (referred to herein as Th1-associated miRs). In particular, the miR-17-92 gene...
8318479 Perfused three-dimensional cell/tissue disease models  
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and...
US20120294956 INHIBITION OF DYNAMIN RELATED PROTEIN 1 TO PROMOTE CELL DEATH  
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i)...
8314149 Protective role of semapimod in necrotizing enterocolitis  
A method is disclosed wherein semapimod, and/or the mesylate salt thereof, is administered for the treatment of necrotizing enterocolitis.
US20120289588 Lipase Inhibitors for the Treatment of Pancreatitis and Organ Failure  
The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor....
US20120288536 Stabilized Stat3 Decoy Oligonucleotides And Uses Therefor  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...
8309599 Synthesis of FR901464 and analogs with antitumor activity  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
8309349 Cell line  
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
US20120283530 METHOD AND APPARATUS TO DETECT CORONARY ARTERY CALCIFICATION OR DISEASE  
Coronary artery calcification (CAC) occurs at an earlier age in diabetes and is a risk factor for coronary artery disease (CAD) in subjects with or without diabetes. One postulated mechanism for...
US20120276220 Method of Treating Hepatitis  
The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
US20120274323 MSC-SELMQC METHOD FOR SIMULTANEOUS MAPPING OF POLYUNSATURATED FATTY ACIDS, LACTATE AND CHOLINE IN HIGH FAT TISSUES  
Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing...
US20120271611 Modeling Wound Healing  
Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue...
US20120271318 ROBOT FOR MINIMALLY INVASIVE INTERVENTIONS  
Rather than trying to immobilize a living, moving organ to place the organ in the fixed frame of reference of a table-mounted robotic device, the present disclosure teaches mounting a robot in the...
US20120269854 Method of Enhancing KSHV LANA1 Immunogenicity  
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LAN...
8288551 Targeted nitroxide agents  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20120252733 USE OF TARGETED NITROXIDE AGENTS IN BONE HEALING  
Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group....
8278188 Manipulation, detection, and assay of small scale biological particles  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. A particle manipulation device contains a plurality of electrodes formed on...
US20120244528 Susceptibility Genes for Age-Related Maculopathy (ARM) on Chromosome 10q26  
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of...
US20120244136 Cardiac-Specific Protein Targeting Domain  
The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their...
US20120237954 BIOMARKERS FOR PROGNOSES OF PULMONARY DISEASES  
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic...
US20120237485 Trabecular Meshwork Stem Cells  
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and...
US20120235997 IMAGE GENERATING APPARATUS, METHOD OF GENERATING IMAGE, PROGRAM, AND RECORDING MEDIUM  
The present application generates an image in which a contour line is drawn about a tuned object A in a virtual three-dimensional space when a part of the tuned object A is overlapped by another...
US20120228137 pH SENSOR  
A pH sensor includes an enclosed fluidic channel, an electrolyte solution within the fluidic channel, a first electrode exterior to the fluidic channel, a second electrode within the fluidic...
8264458 Variable compliance joystick with compensation algorithms  
The present invention provides variable compliance joysticks with mechanical and software customization, and with an integrated control capability, and a method of systematically determining the...
8263329 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...