Patents and Patent Applications from University of Pittsburgh


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US20150367033 INJECTABLE PERIPHERAL NERVE SPECIFIC HYDROGEL  
The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following...
US20150366913 Biologic Scaffold For Prevention of Pulmonary Fibrosis  
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived...
9217000 Targeted nitroxide agents  
A compound having a structure of:
9216976 Targeted nitroxide agents  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20150361319 COMPOSITIONS FOR PREVENTION OF ICE BUILD-UP  
A composition comprising a silicone oil or fluorosilicone fluid infused in a cross-linked silicone resin matrix. The silicone oil or fluorosilicone fluid may comprise a linear or branched...
US20150360698 SYSTEMS AND METHOD FOR DRIVING EVALUATION AND TRAINING  
A system for evaluation of an operator of a vehicle including a steering system under observation of an evaluator within the vehicle includes a steering sensor system adapted to measure...
9212207 Computationally optimized broadly reactive antigens for H5N1 and H1N1 influenza viruses  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
9211519 Methods to prepare patchy microparticles  
A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self-assembled microparticles with a...
9211212 Apparatus and method for modulating sleep  
Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and/or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these...
9206233 Templates for controlling synthesis of nanoparticles into discrete assemblies  
An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.
US20150344971 METHOD FOR DIAGNOSIS, PROGNOSIS AND DETERMINATION OF TREATMENT FOR CUTANEOUS T-CELL LYMPHOMA  
The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX,...
9200322 Biomarkers for acute ischemic stroke  
The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke...
9200035 Bifunctional compounds  
A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl...
9199003 Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
9198621 Method, apparatus and system for food intake and physical activity assessment  
Electronic systems, devices and methods are provided to accurately measure both food intake and physical activity in a subject. A device is provided to be placed on a subject which records video...
US20150335807 REMOVAL OF CARBON DIOXIDE VIA DIALYSIS  
A method of reducing the concentration of carbon dioxide in blood plasma includes removing blood from a patient and treating or processing at least blood plasma of the blood by flowing the blood...
US20150335707 USE OF SLURP1 AS AN IMUNOMODULATORY MOLECULE IN THE OCULAR SURFACE  
Methods for treating inflammation are disclosed, such as for treating ocular inflammation. In some embodiments, the ocular inflammation is inflammation of an ocular surface, such as keratitis. The...
9193796 Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
US20150330975 Urinary Biomarkers For Predicting Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
US20150327835 METHOD AND APPARATUS TO DETECT LIPID CONTENTS IN TISSUES USING ULTRASOUND  
A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the...
9187528 Inhibitors of Nox1  
The present invention relates to inhibitors of Nox1-dependent reactive oxygen species production and their use in the treatment of disorders associated with reactive oxygen species, such as...
9187441 p53-Mdm2 antagonists  
Novel p53-Mdm2 antogonists that conform to Formula I or to Formula II: where the prescribed substituent groups are defined, are useful in treating or preventing cancer. In particular, the...
9186408 Nitrated-fatty acids modulation of type II diabetes  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its...
US20150325311 LOW-POWER PULSE WIDTH ENCODING SCHEME AND COUNTER-LESS SHIFT REGISTER THAT MAY BE EMPLOYED THEREWITH  
A method of decoding, an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
US20150322202 METHODS OF ELECTROSPINNING AND COMPOSITIONS MADE THEREFROM  
Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a...
9180167 Activators of CXCR3 for the treatment of angiopathies of the eye  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
US20150315649 METHOD FOR DIAGNOSING AND ASSESSING RISK OF PANCREATITIS USING GENETIC VARIANTS  
The present application discloses methods for predicting the risk of developing, or the presence of, recurrent acute pancreatitis and/or chronic pancreatitis, in a subject, by identifying the...
US20150314059 EXTRACORPOREAL AMBULATOR ASSIST LUNG  
A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow...
US20150310254 SYSTEM AND METHOD FOR AUTOMATED IDENTIFICATION OF ABNORMAL CILIARY MOTION  
A method of classifying ciliary motion includes receiving digital video data representing the ciliary motion generated by an image capture device, wherein the digital video data includes a...
US20150307655 Polyesters, Methods of Making Polyesters and Uses Therefor  
Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue...
US20150307582 ENGINEERED RECEPTORS AND THEIR USE  
Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions...
US20150307512 SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
US20150306183 FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE  
Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild...
US20150306074 FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS  
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In particular,...
US20150306034 FORMULATIONS AND CARRIER SYSTEMS INCLUDING COMPOUND INTERACTIVE DOMAINS  
A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by...
US20150305609 METHOD AND APPARATUS FOR AIDING IN THE DIAGNOSIS OF OTITIS MEDIA BY CLASSIFYING TYMPANIC MEMBRANE IMAGES  
A method of aiding the diagnosis of otitis media in a patient includes obtaining image data in a processor apparatus of a computing device, the image data being associated with at least one...
9169182 Chrysophaentin analogs that inhibit FtsZ protein  
Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for...
US20150297810 ADJUSTABLE LIPOSUCTION CANNULA  
A device for removing fat from a body can include a pair of nested hollow members that each has at least one opening and an adjustment means for adjusting the orientation of the nested hollow...
US20150297798 Extracellular Matrix Mesh Coating  
Provided are surgical meshes embedded in a gelled, solubilized extracellular matrix (ECM) composition, methods of making the same, and methods of using the same to repair defects in a body. The...
US20150297670 "Therapeutic Use of Peptide Inhibitors of NADPH Oxidase; Aerosolization as a Delivery Mechanism"  
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit...
US20150297649 TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY  
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The...
US20150297578 Selective Targeting Agents for Mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20150291534 COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS  
Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef...
US20150290420 METHODS, DEVICES AND SYSTEMS FOR TREATING INSOMNIA BY INDUCING FRONTAL CEREBRAL HYPOTHERMIA  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20150290308 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
9156888 Antibody molecules  
The present invention provides murine monoclonal antibody molecules that bind to Merkel cell carcinoma virus (MCV) polypeptides.
US20150283109 LIPASE INHIBITORS FOR THE TREATMENT OF PANCREATITIS AND ORGAN FAILURE  
The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor....
US20150276983 EFFICIENT WHITE LIGHT SCATTERING PHOTONIC BANDGAP CRYSTAL  
A photonic bandgap crystal or photonic bandgap crystal material comprising a self-assembled crystalline colloidal array (CCA) of monodisperse spherical particles having a face-centered-cubic (fcc)...
9144598 Reverse thermal gels and their use in cell therapy  
Methods are disclosed herein for increasing survival of transplanted cells, either in vitro or in vivo. In additional embodiments, methods are disclosed for treating a subject with a spinal cord...
US20150268448 IMAGING LENS  
An imaging lens includes a first lens group having positive refractive power; a second lens group having positive refractive power; and a third lens group having negative refractive power,...