Patents and Patent Applications from University of Pittsburgh


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9130580 Low-power pulse width encoding scheme and counter-less shift register that may be employed therewith  
A method of decoding an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
9127016 Small molecule inhibitors of Dusp6 and uses therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
9125891 Lymph nodes as a site for regeneration  
Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
US20150247083 PROPPANTS FOR HYDROCARBON RECOVERY  
A method of hydraulic fracturing in a subterranean formation includes injecting a fluid including a proppant into the subterranean formation, wherein the proppant includes a material adapted to...
US20150246939 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury  
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use...
US20150246128 CONDUCTIVE POLYMER GRAPHENE OXIDE COMPOSITE MATERIALS  
A composition includes a composite material including at least one conducting polymer doped with graphene oxide and at least one agent immobilized at least one of (i) on graphene oxide extending...
9121009 Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150241415 EVALUATING RENAL INJURY USING HYALURONIC ACID  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to...
US20150240317 FUNCTIONAL GENOMICS SCREENING PLATFORM FOR HEAD AND NECK CANCER  
The present invention relates to HPV-positive as well as HPV-negative screening platforms that are highly serum-dependent, for use as HNSCC models. These HNSCC models die reproducibly in...
9115357 Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
9114109 Five-coordinate neuroglobin and use thereof as a blood substitute  
Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild...
US20150232526 USE OF RELAXIN TO TREAT ATRIAL FIBRILLATION  
Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
US20150231271 FORMULATIONS AND CARRIER SYSTEMS INCLUDING FARNESYLTHIOSALYCYLIC MOITIES  
A method of forming or creating a formulation for a compound to be delivered includes creating a carrier agent by conjugating at least one hydrophobic domain or hydrophobic compound with at least...
US20150231180 TRABECULAR MESHWORK STEM CELLS  
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and...
US20150230453 COMPOSITIONS AND METHODS FOR ORGAN PRESERVATION  
Disclosed herein are solutions for use with machine perfusion of one or more organs. In some embodiments, the solutions comprise acellular cross-linked hemoglobin in a physiologically acceptable...
9107892 Identification of a novel retrovirus in patients with benign prostatic hyperplasia  
Methods for producing an immune response to a benign prostatic hyperplasia (BPH) virus are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
US20150216824 Treatment of Medium-Chain Acyl-CoA Dehydrogenase Deficiency  
The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can...
9096853 Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity  
A synthesized siRNA molecule having the sense strand with one or more uridine bases replaced by one or more respective nucleoside analogs, such as 5-fluoro-2′-deoxyuridine (FdU).
9096661 Monoclonal antibodies for CSPG4 for the diagnosis and treatment of basal breast carcinoma  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20150209207 SEATING FUNCTION MONITORING AND COACHING SYSTEM  
A wheelchair system includes a wheelchair including at least one adjustable seating function, a sensor system in operative connection with the wheelchair which includes at least one sensor to...
US20150208950 Arterial and Venous Oxygenation Method and Apparatus  
Methods and apparatuses for an oxygen consumption monitoring system are disclosed herein. In one embodiment, an oxygen consumption monitoring system is disclosed. The oxygen consumption monitoring...
US20150208923 Non-Invasive Monitoring of Tissue Mechanical Properties  
Methods and apparatuses for a tissue mechanical property monitoring system are disclosed herein. In one embodiment, a tissue mechanical property monitoring system is disclosed. The tissue...
9089400 Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20150204728 SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY  
Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within...
9084722 Biologic scaffold for prevention of pulmonary fibrosis  
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived...
US20150198440 PATHWAY MEASUREMENT DEVICES, SYSTEMS AND METHODS  
A pathway measurement system hereof includes a rigid frame and a mobility system attached to the frame. The mobility system includes at least one movable element which is adapted to contact a...
US20150197793 GAMMA-PNA MINIPROBES FOR FLUORESCENT LABELING  
A category of γPNA miniprobes and chimeric γPNA probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes...
9080216 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20150194066 MEDICAL DEVICE TRAINING SYSTEMS AND METHODS OF USING  
A smart peripheral device for use in a medical training system. The medical training system having a processing device, software to emulate aspects of a medical device and a display in...
US20150191786 Genetic Polymorphisms Associated With Advanced Lung Diseases  
The present invention relates to methods and compositions that may be used to predict the risk of an individual, for example a smoker, for developing chronic obstructive pulmonary disease...
US20150191698 ADIPOSE-DERIVED STEM CELLS AND LATTICES  
The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells...
US20150190400 THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
9072772 Methods of treating disorders associated with protein aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
9072760 TLR4 inhibitors for the treatment of human infectious and inflammatory disorders  
The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In...
US20150182663 Extracellular Matrix Based Gastroesophageal Junction Reinforcement Device  
Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part...
9066902 Fatty acids as anti-inflammatory agents  
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In...
US20150175607 P62-ZZ CHEMICAL INHIBITOR  
A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one p62-ZZ...
9062121 Stabilized STAT3 decoy oligonucleotides and uses therefore  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...
US20150169985 AUTOMATED EPITHELIAL NUCLEI SEGMENTATION FOR COMPUTATIONAL DISEASE DETECTION ALGORITHMS  
In aspects, the subject innovation can comprise systems and methods capable of automatically labeling cell nuclei (e.g., epithelial nuclei) in tissue images containing multiple cell types. The...
US20150165073 THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
US20150164956 Muscle-Derived Cells (MDCs) for Treating Muscle- or Bone-Related Injury or Dysfunction  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
US20150164491 STEERABLE, FOLLOW THE LEADER DEVICE  
A highly articulated robotic probe (HARP) is comprised of a first mechanism and a second mechanism, one or both of which can be steered in desired directions. Each mechanism can alternate between...
9057722 Urinary biomarkers for predicting long-term dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
9053641 Real-time X-ray vision for healthcare simulation  
A medical procedure training system and method for using is provided. The system includes a sensing system structured to detect the position and motion of a medical device inserted into a...
US20150153331 METABOLOMICS IN PNEUMONIA AND SEPSIS  
The present invention describes a global metabolomic profile of patients with community acquired pneumonia (CAP) and sepsis. The metabolomic profile of endogenous small molecules blood was...
US20150152041 FBXO3 INHIBITORS  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; andR1-R10 are each individually H, optionally-substituted alkyl,...
US20150150853 PROMOTING SLEEP USING AT1 RECEPTOR BLOCKERS  
The present invention relates to the use of an Angiotensin II type 1 (AT1) receptor blocker for promoting sleep and/or the treatment of insomnia. It is based, at least in part, on the results of...
US20150150673 Bioerodible Wraps and Uses There  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
US20150141817 METHODS AND DEVICES FOR ULTRASOUND CONTRAST-ASSISTED THERAPY  
Various methods of performing ultrasound contrast assisted therapy are provided. One such method includes delivering a plurality of microbubble-based ultrasound contrast agents to a target area...
US20150141507 MELANOMA CHEMOPREVENTION  
Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral...