Patents and Patent Applications from University of Pittsburgh


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8993744 Universal dengue virus sequences and methods of use  
Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments...
US20150088183 SURGICAL TOOL MONITORING SYSTEM AND METHODS OF USE  
A device for simultaneously monitoring the health of surgical drills and detecting proximity to critical structures during surgery is described herein. By using various sensors (e.g. microphones,...
US20150086977 GRAPHENE COMPOSITION, METHOD OF FORMING A GRAPHENE COMPOSITION AND SENSOR SYSTEM COMPRISING A GRAPHENE COMPOSITION  
A device including a composition formed by oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide. A composition includes...
US20150086535 Use of Survivin Antagonists in Polyomavirus-Related Disease  
A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient is provided, comprising administering to the patient a therapeutically effective amount of a...
8986671 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150081328 SYSTEM FOR HOSPITAL ADAPTIVE READMISSION PREDICTION AND MANAGEMENT  
A method of determining a probability of readmission of a patient includes receiving patient data from a plurality of information sources; calculating the probability of readmission of the patient...
US20150080229 PLASMA MICRORIBONUCLEIC ACIDS AS BIOMARKERS FOR ENDOMETRIOSIS AND ENDOMETRIOSIS-ASSOCIATED OVARIAN CANCER  
The present invention relates to methods and compositions for differentiating between absence of disease, endometriosis, and EAOC or serous ovarian cancer in a subject. It is based, at least in...
US20150079026 Controlled Release Formulations for the Induction and Proliferation of Blood Cells  
The absence of regulatory T cells (Treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of Treg...
8981914 Portable haptic force magnifier  
An improved system for magnifying forces perceived by an operator performing delicate procedures with a tool. The system senses forces between the tip and handle of the tool and actuates forces...
US20150073290 DETECTION OF ACETONE VIA NANOSTRUCTURE SENSORS  
A method of detecting at least one of analyte in an environment (such as in breath) includes providing a structure including nanostructures in contact with titanium dioxide, applying...
US20150071887 Soft Tissue and Bone Augmentation and Bulking Utilizing Muscle-Derived Progenitor Cells, Compositions and Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
8974542 Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions  
Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The...
US20150065488 METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN POLYMERIZATION  
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine,...
US20150065443 EMBELIN-BASED DELIVERY SYSTEM FOR WATER-INSOLUBLE ACTIVE AGENTS  
A composition having a structure of: X-L-Y wherein X comprises at least one embelin moiety;L comprises a linker; andY comprises a hydrophilic moiety.Also disclosed is a micelle that includes:a...
US20150064724 BIOMARKERS FOR PROGNOSES OF PULMONARY DISEASES  
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic...
US20150064136 PREDICTORS OF PATIENT RESPONSE TO INTERFERON-A THERAPY  
The present invention relates to methods and materials for more effectively treating patients with interferon. It is based on the discovery that clinical response to interferon (IFN) therapy is...
8969326 Estrogen antagonists as treatments for sclerosing disorders  
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen...
US20150056217 USE OF TOLL-LIKE RECEPTOR-9 AGONISTS, TOLL-LIKE RECEPTOR-4 ANTAGONISTS, AND/OR NUCLEAR OLIGOMERIZATION DOMAIN-2 AGONISTS FOR THE TREATMENT OR PREVENTION OF TOLL-LIKE RECEPTOR-4 ASSOCIATED DISORDERS  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic...
8962570 Therapeutic use of peptide inhibitors of NADPH oxidase; aerosolization as a delivery mechanism  
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit...
8961954 Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150050647 Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse  
The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a...
8957036 Targeted delivery of glycine receptors to excitable cells  
The invention provides a method of modulating electrophysiological activity of an excitable cell. The method involves causing exogenous expression of a glycine receptor (GlyR) protein in an...
US20150045412 USE OF THE CHROMOSOME 19 MICRORNA CLUSTER (C19MC) FOR TREATING MICROBIAL DISEASE AND PROMOTING AUTHOPHAGY  
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental...
US20150045304 BONE SUBSTITUTE NANOCOMPOSITES AND METHODS OF SYNTHESIS USING MULTIPHOSPHORYLATED PEPTIDES  
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ No. 2, RRRGDEDE(SSD)nDEG indicated by SEQ No. 3, and LKKLKKLDEDE(SSD)nDEG...
US20150044655 DRUG SIMULANT RECOGNITION SYSTEM AND METHOD OF EMPLOYING  
A system for identifying a drug simulant includes an electronic sensing system structured to measure the value of an inherent property of the drug simulant; a processing unit in electrical...
US20150044247 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H3N2, H2N2, AND B INFLUENZA VIRUSES  
Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA...
US20150044185 Bone Augmentation Utilizing Muscle-Derived Progenitor Compositions in Biocompatible Matrix, and Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
US20150038561 MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF  
Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped,...
US20150038468 ESTROGEN ANTAGONISTS AS TREATMENTS FOR SCLEROSING DISORDERS  
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen...
8945538 Bone substitute compositions, methods of preparation and clinical applications  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium...
8944939 Inertial measurement of sports motion  
Systems and methods of motion tracking are disclosed that can be used in connection with sports motion. Such a method can include placing one or more inertial measurement units (IMUs) on at least...
US20150030628 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR INFLUENZA  
The development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates is described. The optimized HA protein was...
8940277 Intracellular microbubble for imaging an anatomical site  
This invention addresses the clinical problem of how to optimize biological cell based therapies, such as stem cell therapy. Currently, cell therapies administered by intravenous, intra-arterial,...
8937086 Compounds for the treatment of pathologies associated with aging and degenerative disorders  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
US20150018905 APPARATUS AND METHOD FOR MODULATING SLEEP  
Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and/or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these...
US20150018417 FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS  
A class of enzymatically generated electrophilic fatty acid derivatives (EFADs), or their enzymatically generated metabolites. The EFAD's and their metabolites have beneficial effects human...
US20150018346 COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
US20150017262 INHIBITION OF DYNAMIN RELATED PROTEIN 1 TO PROMOTE CELL DEATH  
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i)...
US20150017220 Rapid Preparation of Stem Cell Matrices for Use in Tissue and Organ Treatment and Repair  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
US20150017196 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H5N1 AND H1N1 INFLUENZA VIRUSES  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
US20150010919 Polysiloxane Substrates with Highly-Tunable Elastic Modulus  
A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for...
US20150010832 CATHODES AND ELECTROLYTES FOR RECHARGEABLE MAGNESIUM BATTERIES AND METHODS OF MANUFACTURE  
The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g.,...
US20150010510 Bone-Derived Extra Cellular Matrix Gel  
Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
8927521 Cyclic adenosine monophosphates for reducing the formation of adhesions  
Provided herein are methods of reducing adhesion formation in a subject, for example, post-surgical abdominal and pelvic adhesions. The methods include the step of administering to the subject in...
8927231 Separatome-based protein expression and purification platform  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
8927003 Extracellular matrix based gastroesophageal junction reinforcement device  
Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part...
US20150005613 METHOD AND APPARATUS TO ENHANCE LIGHT ILLUMINATING INTENSITY AND DIFFUSIVITY  
Photoacoustic probes include reflective surfaces situated to redirect scattered or reflected optical radiation from a specimen surface back to the specimen. A reflective coating can reflect probe...
US20150005607 BIOMIMETIC COATING FOR NEURAL IMPLANTS  
Disclosed herein are neural probes comprising an L1 polypeptide functional fragment thereof on the exterior surface of the probe, devices including such electrodes, and methods of their use. The...
8923786 Method of controlling RF transmissions to mitigate interference with critical care medical equipment  
Various methods of mitigating RF interference with one or more critical care medical devices is provided, wherein a predetermined threshold energy acceleration value is associated with the one or...
8922065 Wireless energy transfer system  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a...