Patents and Patent Applications from University of Pittsburgh


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9333068 Bioerodible wraps and uses therefor  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
9331189 Low voltage nanoscale vacuum electronic devices  
An electronic device including a first conducting layer, a second conducting layer, and an insulating layer provided between the conducting layers. At least one side wall extends from the first...
US20160114017 INTERLEUKIN-13 RECEPTOR ALPHA 2 PEPTIDE-BASED BRAIN CANCER VACCINES  
Provided herein are interleukin-13 receptor α2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need...
US20160113889 Small Molecule Inhibitors of Dusp6 and Uses Therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
9322827 B-cell antigen presenting cell assay  
Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting...
US20160108104 APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE  
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as...
9318032 Hybrid physical-virtual reality simulation for clinical training capable of providing feedback to a physical anatomic model  
Systems and methods facilitating training in clinical procedures via mixed reality simulations are disclosed. Such a system can comprise a physical model and a virtual model of an anatomic region...
9315867 Compositions and methods for detecting cancer  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
9314340 Joint bioscaffolds  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
US20160101217 RAPID PREPARATION OF STEM CELL MATRICES FOR USE IN TISSUE AND ORGAN TREATMENT AND REPAIR  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
US20160101190 POLYMER-BASED PROTEIN ENGINEERING METHODS TO RATIONALLY TUNE ENZYME ACTIVITY, pH-DEPENDENCE AND STABILITY  
Using a novel water-soluble, active ester amide-containing functionalized controlled radical polymerization initiator, stimuli responsive polymers have been grown from the surface of a protein,...
US20160100755 SIGNAL NORMALIZATION AMONG MULTIPLE OPTICAL COHERENCE TOMOGRAPHY DEVICES  
The present disclosure is directed to systems and methods for normalizing an image of an eye among multiple optical coherence tomography (OCT) devices. The system can receive an OCT image and...
9309290 Computationally optimized broadly reactive antigens for H1N1 influenza  
The generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates is described. The optimized HA polypeptides were...
9304074 Methods for making and compositions of two dimensional particle arrays  
A method of preparation of a 2-D array of particles comprising: mixing the particles and a first liquid, the first liquid having the properties of being soluble in water and reducing surface...
US20160090387 CALCIUM CHANNEL AGONISTS  
Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms...
US20160090366 TREATMENT OF PULMONARY AND OTHER CONDITIONS  
Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each...
US20160089414 NOVEL INHIBITORS OF NOX1  
The present invention relates to inhibitors of Nox1-dependent reactive oxygen species production and their use in the treatment of disorders associated with reactive oxygen species, such as...
9296990 Oxygen depletion devices and methods for removing oxygen from red blood cells  
An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed...
9296811 Methods for treating a tumor using an antibody that specifically binds HMW-MAA  
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer...
9295696 Compositions and methods for restoring or rejuvenating stem/progenitor cell function  
This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or...
US20160083351 TETRAHYDROISOQUINOLINES AS SELECTIVE NADPH OXIDASE 2 INHIBITORS  
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed...
US20160082115 Reverse Thermal Gels and Uses Therefor  
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower...
US20160076827 VARIABLE THERMAL INSULATION  
A device for selectively controlling the passage of thermal energy through the device from a first space to a second space by selectively varying an overall thermal conductivity of the device...
US20160074521 PEPTIDE-MEDIATED INTRAVESICAL DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS  
The present invention relates to compositions comprising therapeutic and/or diagnostic anionic agents together with cationic peptides and their use in methods for delivering the anionic agents to...
9285443 MSC-SelMQC method for simultaneous mapping of polyunsaturated fatty acids, lactate and choline in high fat tissues  
Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing...
9285338 Separation of particles using multiplexed dielectrophoresis  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. Time-multiplexed dielectrophoresis can be employed by cycling between two...
9283200 Treatment of medium-chain acyl-CoA dehydrogenase deficiency  
The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can...
US20160068556 TARGETED NITROXIDE AGENTS  
A compound having a structure of:
US20160067376 BONE SUBSTITUTE NANOCOMPOSITES AND METHODS OF SYNTHESIS USING MULTIPHOSPHORYLATED PEPTIDES  
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ NO. 2, RRRGDEDE(SSD)nDEG indicated by SEQ NO. 3, and LKKLKKLDEDE(SSD)nDEG...
9280746 Posterior probability of diagnosis index  
The likelihood of a disorder can be determined using a variety of techniques. One or more exhibited symptoms may be obtained for a patient. The likelihood that each symptom will be exhibited for...
9277999 Joint bioscaffolds  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
US20160058794 LYMPH NODE AS A SITE FOR TRANSPLANTATION, ORGANOGENESIS AND FUNCTION FOR MULTIPLE TISSUES AND ORGANS  
The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of...
US20160053134 PEM LAYER-BY-LAYER SYSTEMS FOR COATING SUBSTRATES TO IMPROVE BIOACTIVITY AND BIOMOLECULE DELIVERY  
The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates'...
US20160052969 TEMPLATES FOR CONTROLLING SYNTHESIS OF NANOPARTICLES INTO DISCRETE ASSEMBLIES  
An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.
US20160051709 COMPOSITION-CONTROLLED NOBLE METAL-TRANSITION METAL SMALL NANOPARTICLE ALLOYS WITH NIR-EMISSION AND HIGH T2 RELAXIVITY AND METHOD FOR MAKING SAME  
A method for producing small nanoparticles of a discrete noble metal-transition metal nanoparticle alloy, comprising: mixing, at room temperature in air, a first aqueous solution having a first...
9265582 Robot for minimally invasive interventions  
Rather than trying to immobilize a living, moving organ to place the organ in the fixed frame of reference of a table-mounted robotic device, the present disclosure teaches mounting a robot in the...
US20160046696 METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA  
The present invention provides murine monoclonal antibody molecules that bind to Merkel cell carcinoma (MCV) polypeptides.
US20160045552 METHOD AND COMPOSITION FOR TREATING INFLAMMATORY BOWEL DISEASE WITHOUT COLECTOMY  
Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which...
US20160045467 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its...
9260754 Connexin mutation detection for lymphatic variation and disease  
Methods are provided for identifying risk of developing lymphedema, including primary and secondary edema. The methods comprise identifying the presence in a biological sample of a polymorphism in...
US20160039910 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARBOXYHEMOGLOBINEMIA  
Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified...
US20160038578 FULLY HUMAN ANTIBODIES TO HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN AND USES THEREOF  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
9254234 Robotic strong arm  
A robotic strong arm (RSA) for assisting in the transfer of a person from a first surface to a second surface, comprising: first and second members, wherein in each member comprises a prismatic...
9249398 Use of mycobacterium smegmatis trehalose dimycolate hydrolase  
Methods are disclosed herein for treating an infection with a Mycobacterium infection. Methods are also disclosed for treating a Mycobacterium biofilm. The method include the use of trehalose...
9249184 Cardiac-specific protein targeting domain  
The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their...
US20160022872 CELL-BASED COMPOSITIONS, CELL-BASED BANDAGE DEVICES AND SYSTEMS AND METHODS OF TREATMENT THEREWITH  
A composition includes a biodegradable matrix, cells within the biodegradable matrix and at least one bioactive agent having limited mobility relative to the cells within the biodegradable matrix....
US20160022805 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR HUMAN AND AVIAN H5N1 INFLUENZA  
Described herein is the generation of optimized H5N 1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides...
US20160022779 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
US20160020382 OXIDE INTERFACE DISPLAYING ELECTRONICALLY CONTROLLABLE FERROMAGNETISM  
A structure includes an electronically controllable ferromagnetic oxide structure that includes at least three layers. The first layer comprises STO. The second layer has a thickness of at least...
9237945 Bioerodible wraps and uses therefor  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...