Patents and Patent Applications from University of Pittsburgh


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US20160175395 USE OF OSTEOPROTEGERIN (OPG) TO INCREASE HUMAN PANCREATIC BETA CELL SURVIVAL AND PROLIFERATION  
It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an...
US20160174816 STEERABLE, FOLLOW THE LEADER DEVICE  
A highly articulated robotic probe (HARP) is comprised of a first mechanism and a second mechanism, one or both of which can be steered in desired directions. Each mechanism can alternate between...
9370551 Compositions and methods of treating head and neck cancer  
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features...
US20160166677 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were...
US20160166522 TREATMENT OF MEDIUM-CHAIN ACYL-CoA DEHYDROGENASE DEFICIENCY  
The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can...
9368274 Resonance-based wireless power transfer system  
A wireless power transfer system including a driver coil array, a hexagonally-packed transmitter mat, a receiver coil, and a load coil for powering a medical implant. The magnetically coupled...
9365616 Use of endostatin peptides for the treatment of fibrosis  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
9365597 Mitochondria-targeted inhibitors of cytochrome c peroxidase for protection from apoptosis  
The present application is directed to novel imidazole-substituted fatty acids that have been functionalized with an alkyl triphenylphosphonium group, compositions comprising these compounds and...
9364555 Pederin and psymberin agents  
Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be...
US20160157868 PERFUSION DEVICE FOR TREATING AN INJURED BLOOD VESSEL  
The present disclosure concerns embodiments of an implantable perfusion device that can be implanted in an injured blood vessel to control bleeding without occluding the vessel. In one specific...
9360414 Light refraction imaging to measure liquid volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
9359402 EphA2 T-cell epitope agonists and uses therefore  
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative...
9359284 Benzathine analogs  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; andR1-R10 are each individually H, optionally-substituted alkyl,...
9358301 Reverse thermal gels and uses therefor  
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower...
US20160154077 MSC-SELMQC METHOD FOR SIMULTANEOUS MAPPING OF POLYUNSATURATED FATTY ACIDS, LACTATE AND CHOLINE IN HIGH FAT TISSUES  
Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing...
US20160153000 NON-TOXIC HSV VECTORS FOR EFFICIENT GENE DELIVERY APPLICATIONS AND COMPLEMENTING CELLS FOR THEIR PRODUCTION  
The invention provides a herpes simplex virus (HSV) vector that does not express toxic HSV genes in non-complementing cells and which comprises a genome comprising one or more transgenes, wherein...
US20160151269 COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
9352004 Muscle-derived cells (MDCs) for treating muscle- or bone-related injury or dysfunction  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
US20160145343 ANTI-MUCIN 1 BINDING AGENTS AND USES THEREOF  
This disclosure provides anti-MUC1 binding agents (e.g., antibodies and chimeric antigen receptors) and methods of treatment, prophylaxis, detection, and diagnosis using the same.
US20160143741 JOINT BIOSCAFFOLDS  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
9347939 Method for making polymer single nanowires and sensors utilizing the same  
A method of fabricating polymer single nanowires, comprising the steps of: spin coating a polymethylmethacrylate resist onto a silicon wafer patterned with at least one gold electrode pair;...
9345770 Immunogenic tumor associated stromal cell antigen peptides and methods of their use  
Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides are useful for methods of eliciting...
US20160137975 GENERATION OF MALE GERM CELLS  
Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia...
US20160137692 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20160136407 MICRONEEDLE ARRAYS FOR CANCER THERAPY APPLICATIONS  
A method of forming a microneedle array can include forming a microneedle array having one or more chemotherapeutic agents. The microneedle array can include a base portion and plurality of...
US20160135917 POWERING AND READING IMPLANTED DEVICES  
A method of providing RF energy to a wireless transponder device includes outputting primary RF energy in a form wherein the primary RF energy comprises a plurality of RF bursts, with each...
9340608 Antibodies to endoplasmin and their use  
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies,...
9340602 Matricryptic ECM peptides for tissue reconstruction  
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in...
US20160129155 MUSCULOSKELETAL TISSUE FABRICATION  
Described herein are methods of fabricating human cell-based engineered musculoskeletal tissues (hCEMTs) using three dimensional fabrication technology that involves injectable materials with in...
US20160129021 STERILIZATION METHOD  
The present invention relates to methods of decreasing sperm production in a male mammal by administering an effective amount of SHP2 inhibitor to decrease the spermatogonial stem cell (SSC)...
US20160128938 FORMULATIONS AND CARRIER SYSTEMS INCLUDING COMPOUND INTERACTIVE DOMAINS  
A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by...
US20160128864 APPARATUS AND METHOD FOR MODULATING SLEEP  
Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and/or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these...
9334496 Antisense EGFRAS guanidinium peptide nucleic acid (GPNA) oligonucleotides as antitumor agents  
A class of antisense agents having a distributed guanidinium peptide nucleic acids (GPNA) backbone which has excellent uptake into mammalian cells, can bind to the target DNA or RNA in a highly...
9333239 Use of osteoprotegerin (OPG) to increase human pancreatic beta cell survival and proliferation  
It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an...
9333068 Bioerodible wraps and uses therefor  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
9331189 Low voltage nanoscale vacuum electronic devices  
An electronic device including a first conducting layer, a second conducting layer, and an insulating layer provided between the conducting layers. At least one side wall extends from the first...
US20160114017 INTERLEUKIN-13 RECEPTOR ALPHA 2 PEPTIDE-BASED BRAIN CANCER VACCINES  
Provided herein are interleukin-13 receptor α2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need...
US20160113889 Small Molecule Inhibitors of Dusp6 and Uses Therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
9322827 B-cell antigen presenting cell assay  
Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting...
US20160108104 APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE  
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as...
9318032 Hybrid physical-virtual reality simulation for clinical training capable of providing feedback to a physical anatomic model  
Systems and methods facilitating training in clinical procedures via mixed reality simulations are disclosed. Such a system can comprise a physical model and a virtual model of an anatomic region...
9315867 Compositions and methods for detecting cancer  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
9314340 Joint bioscaffolds  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
US20160101217 RAPID PREPARATION OF STEM CELL MATRICES FOR USE IN TISSUE AND ORGAN TREATMENT AND REPAIR  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
US20160101190 POLYMER-BASED PROTEIN ENGINEERING METHODS TO RATIONALLY TUNE ENZYME ACTIVITY, pH-DEPENDENCE AND STABILITY  
Using a novel water-soluble, active ester amide-containing functionalized controlled radical polymerization initiator, stimuli responsive polymers have been grown from the surface of a protein,...
US20160100755 SIGNAL NORMALIZATION AMONG MULTIPLE OPTICAL COHERENCE TOMOGRAPHY DEVICES  
The present disclosure is directed to systems and methods for normalizing an image of an eye among multiple optical coherence tomography (OCT) devices. The system can receive an OCT image and...
9309290 Computationally optimized broadly reactive antigens for H1N1 influenza  
The generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates is described. The optimized HA polypeptides were...
9304074 Methods for making and compositions of two dimensional particle arrays  
A method of preparation of a 2-D array of particles comprising: mixing the particles and a first liquid, the first liquid having the properties of being soluble in water and reducing surface...
US20160090387 CALCIUM CHANNEL AGONISTS  
Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel agonists and corresponding salt forms...
US20160090366 TREATMENT OF PULMONARY AND OTHER CONDITIONS  
Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each...