Patents and Patent Applications from University of Pittsburgh


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9506032 Engineered biological pacemakers  
Biological pacemakers engineered to intrinsically generate rhythmic excitations are disclosed. In addition, methods of producing the biological pacemakers are disclosed. Methods of treating or...
9504424 Skin screw electrodes  
Electrodes providing excellent recording and physical stability. Electrodes are disclosed that may include a plurality of small teeth that possess a novel design shape and orientation. The shallow...
US20160339048 URIDINE DIPHOSPHATE COMPOUNDS AS MOBILIZERS OF HEMATOPOIETIC PROGENITOR CELLS  
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for...
US20160339002 PEDIATRIC ORAL SUSPENSION FORMULATIONS OF AMOXICILLIN AND CLAVULANATE POTASSIUM AND METHOD FOR USING SAME  
The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is present in an amount equal to or less than...
US20160338984 PARTICLE FORMULATIONS OF ALL-TRANS RETINOIC ACID AND TRANSFORMING GROWTH FACTOR BETA FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS  
Particle formulations are disclosed that include polymeric particles containing a small molecule drug and a high molecular weight therapeutic protein. Methods of making and using the particle...
9499791 Skeletal muscle augmentation utilizing muscle-derived progenitor compositions, and treatments thereof  
The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following...
9498221 Implantable medical devices having double walled microspheres  
An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
US20160332943 CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY  
The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high...
US20160331833 Method of Enhancing KSHV LANA1 Immunogenicity  
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LANA1...
9492450 Inhibition of dynamin related protein 1 to promote cell death  
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i)...
9492408 Protection from chemical-induced acute lung injury  
Methods are provided herein for treating an individual having a disease, disorder or condition affecting the lungs, wherein said disease, disorder, or condition of the lung is an acute lung...
9492313 Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders  
A method and device for treating neurological disorders involving the application of noninvasive, regional brain thermal stimulation to a region of a patient's head associated with a subject...
US20160330551 SYSTEM AND METHOD FOR ENHANCING THE BINAURAL REPRESENTATION FOR HEARING-IMPAIRED SUBJECTS  
A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated...
US20160327540 Light Refraction Imaging to Measure Liquid Volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
US20160325016 Biohybrid Composite Scaffold  
A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs....
9490028 Low-power pulse width encoding scheme and counter-less shift register that may be employed therewith  
A method of decoding, an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
9489731 Directional diffusion fiber tracking  
Systems and methods facilitating high definition fiber tracking are disclosed. These systems and methods can utilize a directional Axonal Volume (dAV) value that can quantify the direction and...
9488710 MRI pulse sequence based on Q-space trajectory technique  
Systems and methods capable of improving acquisition times associated with obtaining diffusion-weighted magnetic resonance imaging data are discussed. In aspects, multiple points in q-space can be...
US20160317385 AUTOMATIC CHEST COMPRESSION SYSTEMS THAT INCORPORATE BIOLOGICAL FEEDBACK  
Automated CPR systems incorporating biological feedback can include an automated compression piston system, a data acquisition system, computer systems for running various control algorithms,...
US20160317280 Bioerodible Wraps and Uses Therefor  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
9483685 System and method for automated identification of abnormal ciliary motion  
A method of classifying ciliary motion includes receiving digital video data representing the ciliary motion generated by an image capture device, wherein the digital video data includes a...
9482638 Graphene composition, method of forming a graphene composition and sensor system comprising a graphene composition  
A device including a composition formed by oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide. A composition includes...
9480776 Extracellular matrix based gastroesophageal junction reinforcement device  
Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part...
US20160313334 METHODS FOR THE DETECTION OF ESOPHAGEAL ADENOCARCINOMA  
Methods are disclosed for detecting the likelihood that a subject will develop esophageal adenocarcinoma. Methods are also disclosed for determining if an agent is effective for treatment or...
US20160313277 METHOD FOR MAKING POLYMER SINGLE NANOWIRES AND SENSORS UTILIZING THE SAME  
A method of fabricating polymer single nanowires, comprising the steps of: spin coating a polymethylmethacrylate resist onto a silicon wafer patterned with at least one gold electrode pair;...
US20160310447 COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE  
A method for treating a respiratory injury or disease comprising: administering to a patient in need of treatment a pharmaceutical composition comprising a compound of general Formula I: or salt,...
US20160303229 METHODS OF TREATING NECROTIZING ENTEROCOLITIS BY ADMINISTERING NUCLEAR OLIGOMERIZATION DOMAIN-2 AGONISTS,TLR9 AGONISTS AND TLR4 ANTAGONISTS  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic...
US20160303187 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE  
It is an object of the present invention to provide methods and compositions for protection of subjects from acute kidney injury by treating the subject with compounds that modulate the cell...
US20160303169 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
9469684 Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
9469677 Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition  
The invention relates to biomimetic peptide-containing compositions for use, in particular, for application and or deposition on a magnesium alloy, e.g., substrate, to at least partially coat a...
US20160297934 THICKENING COMPOSITIONS, AND RELATED MATERIALS AND PROCESSES  
A silicone polymer is provided, modified with at least one functional group from the class of anthraquinone amide groups; anthraquinone sulfonamide groups; thioxanthone amide groups; or...
US20160288212 METHOD FOR PRODUCING SMALL METAL ALLOY NANOPRTICLES  
A method for producing small metal alloy nanoparticles of a first metal and a second metal, comprising: mixing, at room temperature in air, a first aqueous solution of first and second metal...
US20160287548 MELANOMA CHEMOPREVENTION  
Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral...
US20160287239 ENDOSCOPIC PORTS FOR MINIMALLY INVASIVE SURGICAL ACCESS AND METHODS OF USE THEREOF  
A method for providing an endoscopic port includes inserting a distal portion of an expandable member into soft tissue in a patient's body. The distal portion of the expandable member is inflated...
US20160282344 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF SEPSIS  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients and in patients at risk for sepsis. In...
US20160279299 SILK FIBROIN-BASED FLUID DELIVERY SYSTEMS AND DEVICES  
The present invention is directed to systems and/or biopolymer devices and methods of using the same. The systems and/or biopolymer devices described herein can be used for delivery of a fluid...
US20160279226 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H5N1 AND H1N1 INFLUENZA VIRUSES  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
9454509 Active stability devices and systems for mobile devices  
A system for use with a mobile device includes at least one sensor to sense a variable related to tilting of the mobile device and at least one activatable system in operative connection with the...
9452200 Activators of CXCR3 for the treatment of angiopathies of the eye  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
9452171 Methods of treating disorders associated with protein aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
9451885 Depth-selective fiber-optic probe  
Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can...
US20160271381 BIOACTIVE COMPONENTS CONJUGATED TO SUBSTRATES OF MICRONEEDLE ARRAYS  
Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in...
9449144 Flux balance analysis with molecular crowding  
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
9447449 Recombinant mycobacteriophages for delivery of nucleic acids of interest into mycobacteria  
Methods are provided for detecting mycobacteria in a sample, including clinical samples. Methods are also provided for determining susceptibility of mycobacterial strains to known or potential...
9445874 Graft devices and methods of use  
A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a...
US20160264540 COMPOUNDS FOR TREATING PROSTATE CANCER  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: R20—(Z)b—(Y)c—(R21)a—X—R22-R23 wherein R20 is an aryl, substituted aryl, heteroaryl, substituted...
US20160263161 Muscle Derived Cells for the Treatment of Gastro-Esophageal Pathologies and Methods of Making and Using the Same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20160263156 RED BLOOD CELL MEMBRANE-DERIVED MICROPARTICLES AND THEIR USE FOR THE TREATMENT OF LUNG DISEASE  
Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis,...
9443128 Segmenting biological structures from microscopy images  
A method performed by one or more processors, includes: receiving an image to be segmented into one or more representations of one or more biological structures; accessing data representing a set...