Patents and Patent Applications from University of Pittsburgh


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US20160279299 SILK FIBROIN-BASED FLUID DELIVERY SYSTEMS AND DEVICES  
The present invention is directed to systems and/or biopolymer devices and methods of using the same. The systems and/or biopolymer devices described herein can be used for delivery of a fluid...
US20160279226 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H5N1 AND H1N1 INFLUENZA VIRUSES  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
9454509 Active stability devices and systems for mobile devices  
A system for use with a mobile device includes at least one sensor to sense a variable related to tilting of the mobile device and at least one activatable system in operative connection with the...
9452200 Activators of CXCR3 for the treatment of angiopathies of the eye  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
9452171 Methods of treating disorders associated with protein aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
9451885 Depth-selective fiber-optic probe  
Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can...
US20160271381 BIOACTIVE COMPONENTS CONJUGATED TO SUBSTRATES OF MICRONEEDLE ARRAYS  
Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in...
9449144 Flux balance analysis with molecular crowding  
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
9447449 Recombinant mycobacteriophages for delivery of nucleic acids of interest into mycobacteria  
Methods are provided for detecting mycobacteria in a sample, including clinical samples. Methods are also provided for determining susceptibility of mycobacterial strains to known or potential...
9445874 Graft devices and methods of use  
A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a...
US20160264540 COMPOUNDS FOR TREATING PROSTATE CANCER  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: R20—(Z)b—(Y)c—(R21)a—X—R22-R23 wherein R20 is an aryl, substituted aryl, heteroaryl, substituted...
US20160263161 Muscle Derived Cells for the Treatment of Gastro-Esophageal Pathologies and Methods of Making and Using the Same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20160263156 RED BLOOD CELL MEMBRANE-DERIVED MICROPARTICLES AND THEIR USE FOR THE TREATMENT OF LUNG DISEASE  
Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis,...
9439919 Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells  
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for...
9439877 Small molecule inhibitors of Dusp6 and uses therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
US20160258010 ALLELE SPECIFIC PCR ASSAY FOR DETECTION OF NUCLEOTIDE VARIANTS  
Described herein are improved methods for detecting one or more alleles of a target nucleic acid molecule in a biological sample. The methods can be used, for example, for detecting low-frequency...
US20160257657 SMALL MOLECULE INHIBITORS OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER  
A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted...
US20160256131 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
US20160252719 DEPTH-RESOLVED SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY FOR UNSTAINED TISSUE AND CELLS  
Provided are systems, methods, and other embodiments associated with depth-resolved spatial-domain low-coherence quantitative phase microscopy for high-throughput analysis of 3D nanoscale...
US20160250267 ONCOLYTIC HSV VECTOR  
The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the...
US20160244508 USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
US20160243170 Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function  
This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or...
9421307 Biohybrid composite scaffold  
A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs....
9421229 Neural scaffolds  
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater of vertebrate and can be processed...
US20160237040 BENZATHINE ANALOGS  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; andR1-R10 are each individually H, optionally-substituted alkyl,...
US20160235793 Immuno-Oncolytic Therapies  
The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and/or reduce host immunity and/or antibody response against the virus. It is...
US20160235750 SMALL MOLECULES TARGETING HIV-1 NEF  
A method of treating HIV in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound having a general Formula 1, or a pharmaceutically...
US20160235747 FBXO3 INHIBITORS  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; andR1-R10 are each individually H, optionally-substituted alkyl,...
US20160232324 Systems And Methods For Disease Progression Modeling  
A method for determining a disease state transition path includes receiving a patient data having functional data and/or structural data related to a patient. Based on the patient data, a first...
US20160231330 BIOMARKERS RELATED TO ORGAN FUNCTION  
Disclosed herein are methods of identifying biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) that can be used to predict organ or tissue function or dysfunction. In...
US20160230174 TOLEROGENIC DENDRITIC CELLS TO TREAT INFLAMMATORY BOWEL DISEASE  
Methods are disclosed herein for treating or preventing an inflammatory bowel disease in a subject. These methods include administering to a subject an effective amount of tolerogenic dendritic...
9410124 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
9408855 Thermoresponsive, biodegradable, elastomeric material and uses therefor  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers...
9408571 Apparatus and method for implantation of devices into soft tissue  
Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position...
US20160225427 MAGNETIC-ASSISTED NONDESTRUCTIVE SELF-REFERENCE SENSING METHOD FOR SPIN-TRANSFER TORQUE RANDOM ACCESS MEMORY  
A method of reading a memory cell of a magneto-resistive random access memory device, wherein the memory cell has a ferromagnetic free layer having a first magnetization orientation and a...
US20160223439 METHODS FOR MAKING AND COMPOSITIONS OF TWO DIMENSIONAL PARTICLE ARRAYS  
A method of preparation of a 2-D array of particles comprising: mixing the particles and a first liquid, the first liquid having the properties of being soluble in water and reducing surface...
US20160220651 IMMUNOGENIC TUMOR ASSOCIATED STROMAL CELL ANTIGEN PEPTIDES AND METHODS OF THEIR USE  
Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides are useful for methods of eliciting...
9407999 System and method for enhancing the binaural representation for hearing-impaired subjects  
A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated...
9402895 Method of enhancing KSHV LANA1 immunogenicity  
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LANA1...
9402839 Selective targeting agents for mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20160213716 Bone Augmentation Utilizing Muscle-Derived Progenitor Compositions, And Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
9399655 Catalytic glycosylation with designer thioglycoside and novel protecting groups for same and for synthesis of oligosaccharides  
A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether...
US20160207990 ANTIBODIES TO ENDOPLASMIN AND THEIR USE  
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies,...
US20160206971 TEMPERATURE-ASSISTED ON-COLUMN FOCUSING  
A method of comprising: introducing a sample volume into an inlet end of a liquid chromatography column, wherein the liquid chromatography column includes a focusing segment proximal to the inlet...
US20160206761 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents  
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...
US20160206742 MATERIAL TO PREVENT POST SURGICAL INFECTION  
Biodegradable triblock copolymer compositions are provided which are useful in preventing and inhibiting bleeding and infection following surgery. The copolymers are reverse thermal gels in that...
9394368 Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor  
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII,...
9393225 Melanoma chemoprevention  
Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral...
US20160203737 HYBRID PHYSICAL-VIRTUAL REALITY SIMULATION FOR CLINICAL TRAINING CAPABLE OF PROVIDING FEEDBACK TO A PHYSICAL ANATOMIC MODEL  
Systems and methods facilitating training in clinical procedures via mixed reality simulations are disclosed. Such a system can comprise a physical model and a virtual model of an anatomic region...
US20160202258 B-CELL ANTIGEN PRESENTING CELL ASSAY  
Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting...