Patents and Patent Applications from University of Pittsburgh


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9694061 Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
US20170184696 UNIVERSAL, MODULAR TEMPERATURE CONTROLLED MRI PHANTOM FOR CALIBRATED ANISOTROPIC AND ISOTROPIC IMAGING INCLUDING HOLLOW FLUID FILLED TUBULAR TEXTILES FOR CALIBRATED ANISOTROPIC IMAGING  
A universal, modular, temperature controlled MRI phantom for calibration and validation for anisotropic and isotropic imaging comprises an outer insulating shell configured to be received within...
US20170183732 TRANSCRIPTIONAL SIGNATURE FOR CHLAMYDIAL PELVIC INFLAMMATORY DISEASE  
Methods are provided herein for determining the likelihood that a subject, such as an asymptomatic subject, has chlamydial pelvic inflammatory disease. In some embodiments, the method can...
US20170182319 "Methods and Systems for Achieving a Physiological Response by Pudendal Nerve Stimulation and Blockade"  
Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The...
US20170182128 METHOD OF TREATING HEART FAILURE  
The present invention includes methods, systems, uses, and means for the delivery of one or more anti-fibrotic agents into the pericardial space for the treatment and prevention of heart failure (HF).
US20170181657 METHOD AND SYSTEM FOR MONITORING GLUCOSE TRANSPORT AND METABOLISM BY SPIN-LOCK MAGNETIC RESONANCE  
A method of monitoring glucose transport and/or metabolism in a tissue or an organ of a subject using spin-locking magnetic resonance (MR) includes acquiring pre-glucose MR data by executing a...
9690009 Efficient white light scattering photonic bandgap crystal  
A photonic bandgap crystal or photonic bandgap crystal material comprising a self-assembled crystalline colloidal array (CCA) of monodisperse spherical particles having a face-centered-cubic (fcc)...
9688894 Compositions for prevention of ice build-up  
A composition comprising a silicone oil or fluorosilicone fluid infused in a cross-linked silicone resin matrix. The silicone oil or fluorosilicone fluid may comprise a linear or branched...
US20170174740 KV2.1 CHANNEL-DERIVED PEPTIDES AND METHODS OF USE  
Peptides capable of interfering with the Kv2.1-mediated apoptotic K+ current surge that leads to neuronal cell death are described. The disclosed peptides are derived from the C-terminal region of...
US20170173254 DEVICES, SYSTEMS AND METHODS FOR CELL MODIFICATION  
A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to...
US20170173217 Methods for Preparation of a Terminally Sterilized Hydrogel Derived from Extracellular Matrix  
Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to...
US20170173127 KEXIN-DERIVED VACCINES TO PREVENT OR TREAT FUNGAL INFECTIONS  
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat...
US20170173126 IDENTIFICATION OF PNEUMOCYSTIS ANTIGENS AND USES THEREOF  
Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a...
9682919 Small molecule inhibitors of Dusp6 and uses therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
US20170165048 Device for Changing course of vessel and treatment method using the same  
The present invention relates to a device for changing a course of a vessel, a method of introducing the device, a method of changing a course of a vessel using the device, and a treatment method...
US20170164605 ENDOVASCULAR APPARATUS FOR PERFUSING ORGANS IN A BODY  
In one representative embodiment, a method of perfusing organs in a patient's body is provided. The method comprises isolating the visceral arteries and the visceral veins from blood circulating...
9677088 Adeno associated virus plasmids and vectors  
Disclosed herein are adeno associated viral plasmids and viral vectors. Also disclosed are methods of using adeno associated viral vectors.
9676738 Antifibrotic effects of oxetanyl sulfoxides  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl;X is —S—, —S(O)—, or S(O)2—;R20 and...
9675642 Engineered dendritic cells and uses for the treatment of cancer  
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12...
9675446 Prosthetic implant for medialization thyroplasty  
Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the...
US20170157217 USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
US20170156815 APPARATUS AND METHOD FOR IMPLANTATION OF DEVICES INTO SOFT TISSUE  
Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position...
US20170156699 CONTRAST ASSISTED INTRAVASCULAR ULTRASOUND IMAGING  
A method of imaging a blood vessel includes delivering a bubble-based contrast agent within the vessel and positioning at least one ultrasound device in the vicinity of the bubble-based contrast...
US20170156569 STEERABLE, FOLLOW THE LEADER DEVICE  
A highly articulated robotic probe (HARP) is comprised of a first mechanism and a second mechanism, one or both of which can be steered in desired directions. Each mechanism can alternate between...
9670236 Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury  
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use...
9669185 Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20170152565 METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
US20170151317 PEPTIDE ANALOGS CAPABLE OF ENHANCING STIMULATION OF A GLIOMA-SPECIFIC CTL RESPONSE  
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
9662329 Use of survivin antagonists in polyomavirus-related disease  
A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient is provided, comprising administering to the patient a therapeutically effective amount of a...
9662035 Steady state measurement and analysis approach to profiling auditory evoked potentials from short-latency to long latency  
The present invention relates to methods and systems for profiling evoked potentials in brain electrical activity which apply steady state response concepts to analysis of longer latency responses...
9656417 System and method for mandrel-less electrospinning  
A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for...
9655980 Theranostic platform for targeted cancer therapy and drug delivery monitoring  
A compound that includes a quaterrylene dye moiety as core, and a dendrimeric shell. For example, the compound may comprise at least four dendronized polyamides covalently attached to a...
9655950 Activation of myeloid-derived suppressor cells as a predictor of patient response to interferon-A therapy  
The present invention relates to methods and materials for more effectively treating patients with interferon. It is based on the discovery that clinical response to interferon (IFN) therapy is...
9655869 Estrogen antagonists as treatments for sclerosing disorders  
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen...
US20170135639 SKIN SCREW ELECTRODES  
Electrodes providing excellent recording and physical stability. Electrodes are disclosed that may include a plurality of small teeth that possess a novel design shape and orientation. The shallow...
9649393 Magnetic resonance imaging cell labeling methods and compositions  
The disclosure provides, in part, fluorocarbon imaging reagents and methods for image-guided treatment and/or diagnosis of a subject with a condition associated with an inflammatory response in an...
9649300 Inhibition of WNT, TGF beta and Hippo signaling pathways to treat cancer, organ fibrosis and metabolic disorders  
Compounds, or pharmaceutically acceptable salts or esters thereof, having a structure of: wherein each of R1-R5 is individually selected from H, halogen, optionally substituted alkyl, optionally...
9649285 Treatment of medium-chain acyl-CoA dehydrogenase deficiency  
The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can...
US20170128148 NOVEL TACTILE FEEDBACK SYSTEM FOR ROBOTIC SURGERY  
Apparatuses and methods for the haptic sensation of forces at a remote location. Groups of MEMS-based pressure sensors are combined into sensor arrays. In some embodiments, the pressure sensors...
9642858 Use of resazurin, or analogs thereof, for antibacterial therapy  
A method for treating infection by bacteria in a subject, comprising administering to the subject a therapeutically effective amount of resazurin or a resazurin analog, or a pharmaceutically...
US20170121374 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were...
9636007 Method and apparatus for aiding in the diagnosis of otitis media by classifying tympanic membrane images  
A method of aiding the diagnosis of otitis media in a patient includes obtaining image data in a processor apparatus of a computing device, the image data being associated with at least one...
US20170114102 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA  
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were...
US20170112964 METHOD AND COMPOSITION FOR TREATING INFLAMMATORY BOWEL DISEASE WITHOUT COLECTOMY  
Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which...
US20170112946 METHODS AND MATERIALS FOR INCREASING VIRAL VECTOR INFECTIVITY  
This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors...
US20170107537 IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR RETARGETING TO NOVEL NON-HSV RECEPTORS  
The present invention provides an HSV vector comprising an envelope comprising one or more mutant gB and/or gH envelope glycoproteins, whereby the HSV vector exhibits at least 25% increased...
US20170107262 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR HUMAN AND AVIAN H5N1 INFLUENZA  
Described herein is the generation of optimized H5N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides were...
US20170107190 ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES  
A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl;X is —S—, —S(O)—, or S(O)2—;R20 and...
9627024 Magnetic-assisted nondestructive self-reference sensing method for spin-transfer torque random access memory  
A method of reading a memory cell of a magneto-resistive random access memory device, wherein the memory cell has a ferromagnetic free layer having a first magnetization orientation and a...
9626583 Automated epithelial nuclei segmentation for computational disease detection algorithms  
In aspects, the subject innovation can comprise systems and methods capable of automatically labeling cell nuclei (e.g., epithelial nuclei) in tissue images containing multiple cell types. The...