Patents and Patent Applications from University of Pittsburgh


Match Document Document Title
9066902 Fatty acids as anti-inflammatory agents  
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In...
US20150175607 P62-ZZ CHEMICAL INHIBITOR  
A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one p62-ZZ...
9062121 Stabilized STAT3 decoy oligonucleotides and uses therefore  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...
US20150169985 AUTOMATED EPITHELIAL NUCLEI SEGMENTATION FOR COMPUTATIONAL DISEASE DETECTION ALGORITHMS  
In aspects, the subject innovation can comprise systems and methods capable of automatically labeling cell nuclei (e.g., epithelial nuclei) in tissue images containing multiple cell types. The...
US20150165073 THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
US20150164956 Muscle-Derived Cells (MDCs) for Treating Muscle- or Bone-Related Injury or Dysfunction  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
US20150164491 STEERABLE, FOLLOW THE LEADER DEVICE  
A highly articulated robotic probe (HARP) is comprised of a first mechanism and a second mechanism, one or both of which can be steered in desired directions. Each mechanism can alternate between...
9057722 Urinary biomarkers for predicting long-term dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
9053641 Real-time X-ray vision for healthcare simulation  
A medical procedure training system and method for using is provided. The system includes a sensing system structured to detect the position and motion of a medical device inserted into a...
US20150153331 METABOLOMICS IN PNEUMONIA AND SEPSIS  
The present invention describes a global metabolomic profile of patients with community acquired pneumonia (CAP) and sepsis. The metabolomic profile of endogenous small molecules blood was...
US20150152041 FBXO3 INHIBITORS  
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; andR1-R10 are each individually H, optionally-substituted alkyl,...
US20150150853 PROMOTING SLEEP USING AT1 RECEPTOR BLOCKERS  
The present invention relates to the use of an Angiotensin II type 1 (AT1) receptor blocker for promoting sleep and/or the treatment of insomnia. It is based, at least in part, on the results of...
US20150150673 Bioerodible Wraps and Uses There  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
US20150141817 METHODS AND DEVICES FOR ULTRASOUND CONTRAST-ASSISTED THERAPY  
Various methods of performing ultrasound contrast assisted therapy are provided. One such method includes delivering a plurality of microbubble-based ultrasound contrast agents to a target area...
US20150141507 MELANOMA CHEMOPREVENTION  
Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral...
US20150141488 SMALL MOLECULE INHIBITORS OF RNA BINDING MOTIF (RBM) PROTEINS FOR THE TREATMENT OF ACUTE CELLULAR INJURY  
A method of treating a cellular injury in a subject comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula I: wherein at least one of...
US20150139965 MICROSPHERE-BASED DELIVERY AND EX VIVO MANIPULATION OF DENDRITIC CELLS FOR AUTOIMMUNE THERAPIES  
The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for...
9037445 Flux balance analysis with molecular crowding  
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
9034055 Human-machine interface based on task-specific temporal postural synergies  
A synergy-based human-machine interface that uses low-dimensional command signals to control a high dimensional virtual, robotic or paralyzed human hand is provided. Temporal postural synergies...
US20150133527 REGULATION OF CARDIAC SODIUM CHANNELS BY SIRT1 AND SIRT1 ACTIVATORS  
Methods are provided herein for treating cardiac arrhythmias, such as for treating an arrhythmia syndrome, for example Brugada syndrome, in a subject. In some embodiments, the methods include...
US20150132356 BIOMIMETIC COATING OF MAGNESIUM ALLOY FOR ENHANCED CORROSION RESISTANCE AND CALCIUM PHOSPHATE DEPOSITION  
The invention relates to biomimetic peptide-containing compositions for use, in particular, for application and or deposition on a magnesium alloy, e.g., substrate, to at least partially coat a...
US20150132268 Muscle Derived Cells for the Treatment of Urinary Tract Pathologies and Methods of Making and Using the Same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150132251 Biodegradable Elastomeric Patch for Treating Cardiac or Cardiovascular Conditions  
Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The...
US20150129493 DEVICES, SYSTEMS AND METHODS FOR REDUCING THE CONCENTRATION OF CARBON DIOXIDE IN BLOOD  
A method for removal of at least a portion of carbon dioxide from an aqueous fluid such as a blood fluid includes placing a first surface of at least one membrane through which carbon dioxide and...
9031646 Automated assessment of atrioventricular and ventriculoatrial conduction  
A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An...
US20150126923 TIP-LOADED MICRONEEDLE ARRAYS FOR TRANSDERMAL INSERTION  
A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of...
US20150126846 SKIN SCREW ELECTRODES  
Electrodes providing excellent recording and physical stability. Electrodes are disclosed that may include a plurality of small teeth that possess a novel design shape and orientation. The shallow...
US20150126588 ADENO ASSOCIATED VIRUS PLASMIDS AND VECTORS  
Disclosed herein are adeno associated viral plasmids and viral vectors. Also disclosed are methods of using adeno associated viral vectors.
9024874 Fingertip visual haptic sensor controller  
Systems, methods and devices for capturing environmental image data and providing tactile feedback about the visual environment to a user. One or more image sensing devices are mounted on various...
9023972 Polyesters, methods of making polyesters and uses therefor  
Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue...
9023887 Lipase inhibitors for the treatment of pancreatitis and organ failure  
The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor....
US20150119468 PROTECTION FROM CHEMICAL-INDUCED ACUTE LUNG INJURY  
Methods are provided herein for treating an individual having a disease, disorder or condition affecting the lungs, wherein said disease, disorder, or condition of the lung is an acute lung...
9017260 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
US20150112144 ADAPTIVE OPTICAL LASER BEAM STEERING THROUGH ENDOSCOPE FOR LASER SURGERY IN KIDNEY  
A lightguide is configured to transmit a scanned and/or focused processing beam to a target. The processing beam has a wavefront amplitude and phase set by a spatial light modulator. Suitable...
US20150105882 INERTIAL MEASUREMENT OF SPORTS MOTION  
Systems and methods of motion tracking are disclosed that can be used in connection with sports motion. Such a method can include placing one or more inertial measurement units (IMUs) on at least...
US20150104807 KITS FOR DIAGNOSTIC AND THERAPEUTIC USES OF AUGMENTER OF LIVER REGENERATION IN INFLAMMATORY CONDITIONS  
The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver...
US20150101938 Measurement device with automated calibration  
A system for obtaining a pH measurement comprises a disposable probe and a reusable reader. The disposable probe includes an indicating electrode and a reference electrode. The reader operably...
9006186 Selective targeting agents for mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20150094564 INTELLIGENT ALGORITHMS FOR TRACKING THREE-DIMENSIONAL SKELETAL MOVEMENT FROM RADIOGRAPHIC IMAGE SEQUENCES  
Systems and methods are disclosed that improve conventional tracking and modeling methods for determining three-dimensional bone motion from sequences of radiographic images. These enhancements...
US20150094547 SYSTEM AND METHOD FOR STORING INFORMATION RELATING TO A MEDICAL IMPLANT DEVICE  
A method of storing information relating, to a medical implant device having a number of implant elements includes receiving a first image, the first image showing a surgical site and the medical...
US20150093821 BIODEGRADABLE POLYURETHANES AND USE THEREOF  
A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at...
8993744 Universal dengue virus sequences and methods of use  
Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments...
US20150088183 SURGICAL TOOL MONITORING SYSTEM AND METHODS OF USE  
A device for simultaneously monitoring the health of surgical drills and detecting proximity to critical structures during surgery is described herein. By using various sensors (e.g. microphones,...
US20150086977 GRAPHENE COMPOSITION, METHOD OF FORMING A GRAPHENE COMPOSITION AND SENSOR SYSTEM COMPRISING A GRAPHENE COMPOSITION  
A device including a composition formed by oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide. A composition includes...
US20150086535 Use of Survivin Antagonists in Polyomavirus-Related Disease  
A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient is provided, comprising administering to the patient a therapeutically effective amount of a...
8986671 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150081328 SYSTEM FOR HOSPITAL ADAPTIVE READMISSION PREDICTION AND MANAGEMENT  
A method of determining a probability of readmission of a patient includes receiving patient data from a plurality of information sources; calculating the probability of readmission of the patient...
US20150080229 PLASMA MICRORIBONUCLEIC ACIDS AS BIOMARKERS FOR ENDOMETRIOSIS AND ENDOMETRIOSIS-ASSOCIATED OVARIAN CANCER  
The present invention relates to methods and compositions for differentiating between absence of disease, endometriosis, and EAOC or serous ovarian cancer in a subject. It is based, at least in...
US20150079026 Controlled Release Formulations for the Induction and Proliferation of Blood Cells  
The absence of regulatory T cells (Treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of Treg...
8981914 Portable haptic force magnifier  
An improved system for magnifying forces perceived by an operator performing delicate procedures with a tool. The system senses forces between the tip and handle of the tool and actuates forces...