Patents and Patent Applications from University of Pittsburgh


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US20160082115 Reverse Thermal Gels and Uses Therefor  
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower...
US20160076827 VARIABLE THERMAL INSULATION  
A device for selectively controlling the passage of thermal energy through the device from a first space to a second space by selectively varying an overall thermal conductivity of the device...
US20160074521 PEPTIDE-MEDIATED INTRAVESICAL DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS  
The present invention relates to compositions comprising therapeutic and/or diagnostic anionic agents together with cationic peptides and their use in methods for delivering the anionic agents to...
9285443 MSC-SelMQC method for simultaneous mapping of polyunsaturated fatty acids, lactate and choline in high fat tissues  
Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing...
9285338 Separation of particles using multiplexed dielectrophoresis  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. Time-multiplexed dielectrophoresis can be employed by cycling between two...
9283200 Treatment of medium-chain acyl-CoA dehydrogenase deficiency  
The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can...
US20160068556 TARGETED NITROXIDE AGENTS  
A compound having a structure of:
US20160067376 BONE SUBSTITUTE NANOCOMPOSITES AND METHODS OF SYNTHESIS USING MULTIPHOSPHORYLATED PEPTIDES  
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ NO. 2, RRRGDEDE(SSD)nDEG indicated by SEQ NO. 3, and LKKLKKLDEDE(SSD)nDEG...
9280746 Posterior probability of diagnosis index  
The likelihood of a disorder can be determined using a variety of techniques. One or more exhibited symptoms may be obtained for a patient. The likelihood that each symptom will be exhibited for...
9277999 Joint bioscaffolds  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
US20160058794 LYMPH NODE AS A SITE FOR TRANSPLANTATION, ORGANOGENESIS AND FUNCTION FOR MULTIPLE TISSUES AND ORGANS  
The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of...
US20160053134 PEM LAYER-BY-LAYER SYSTEMS FOR COATING SUBSTRATES TO IMPROVE BIOACTIVITY AND BIOMOLECULE DELIVERY  
The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates'...
US20160052969 TEMPLATES FOR CONTROLLING SYNTHESIS OF NANOPARTICLES INTO DISCRETE ASSEMBLIES  
An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.
US20160051709 COMPOSITION-CONTROLLED NOBLE METAL-TRANSITION METAL SMALL NANOPARTICLE ALLOYS WITH NIR-EMISSION AND HIGH T2 RELAXIVITY AND METHOD FOR MAKING SAME  
A method for producing small nanoparticles of a discrete noble metal-transition metal nanoparticle alloy, comprising: mixing, at room temperature in air, a first aqueous solution having a first...
9265582 Robot for minimally invasive interventions  
Rather than trying to immobilize a living, moving organ to place the organ in the fixed frame of reference of a table-mounted robotic device, the present disclosure teaches mounting a robot in the...
US20160046696 METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA  
The present invention provides murine monoclonal antibody molecules that bind to Merkel cell carcinoma (MCV) polypeptides.
US20160045552 METHOD AND COMPOSITION FOR TREATING INFLAMMATORY BOWEL DISEASE WITHOUT COLECTOMY  
Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which...
US20160045467 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its...
9260754 Connexin mutation detection for lymphatic variation and disease  
Methods are provided for identifying risk of developing lymphedema, including primary and secondary edema. The methods comprise identifying the presence in a biological sample of a polymorphism in...
US20160039910 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARBOXYHEMOGLOBINEMIA  
Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified...
US20160038578 FULLY HUMAN ANTIBODIES TO HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN AND USES THEREOF  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
9254234 Robotic strong arm  
A robotic strong arm (RSA) for assisting in the transfer of a person from a first surface to a second surface, comprising: first and second members, wherein in each member comprises a prismatic...
9249398 Use of mycobacterium smegmatis trehalose dimycolate hydrolase  
Methods are disclosed herein for treating an infection with a Mycobacterium infection. Methods are also disclosed for treating a Mycobacterium biofilm. The method include the use of trehalose...
9249184 Cardiac-specific protein targeting domain  
The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their...
US20160022872 CELL-BASED COMPOSITIONS, CELL-BASED BANDAGE DEVICES AND SYSTEMS AND METHODS OF TREATMENT THEREWITH  
A composition includes a biodegradable matrix, cells within the biodegradable matrix and at least one bioactive agent having limited mobility relative to the cells within the biodegradable matrix....
US20160022805 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR HUMAN AND AVIAN H5N1 INFLUENZA  
Described herein is the generation of optimized H5N 1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides...
US20160022779 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
US20160020382 OXIDE INTERFACE DISPLAYING ELECTRONICALLY CONTROLLABLE FERROMAGNETISM  
A structure includes an electronically controllable ferromagnetic oxide structure that includes at least three layers. The first layer comprises STO. The second layer has a thickness of at least...
9237945 Bioerodible wraps and uses therefor  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
US20160011167 METHODS AND APPARATUS TO MEASURE CONSTITUTIVE RELATIONS AND FIBER ORIENTATION OF SOFT TISSUES  
The systems and methods provided herein relate to the performance of inverse reconstruction algorithms from ultrasound radiofrequency data and stress-strain data. These systems and methods can be...
US20160008394 INORGANIC NITRITE TO IMPROVE CARDIOPULMONARY HEMODYNAMICS  
Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. Sodium nitrite is a naturally occurring compound that is commonly used as...
US20160008127 PROSTHETIC IMPLANT FOR MEDIALIZATION THYROPLASTY  
Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the...
9235465 Recursively determined invertible set approach to correct multiple stuck-at faults in rewritable memory  
Systems and methods are disclosed that facilitate storage and retrieval of data to/from memory with permanent faults. Permanent “stuck at” faults, associated with individual bits, interfere with...
9234026 Apolipoprotein E polypeptides and their use  
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as...
9234008 Computationally optimized broadly reactive antigens for H3N2, H2N2, and B influenza viruses  
Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA...
US20160000554 APPARATUS AND METHOD FOR REGENERATION OF LIGAMENTS AND TENDONS  
A method for repairing a ligament or tendon, the method comprising: passing one or more sutures through and/or around each respective end of a completely or partially torn ligament or tendon;...
US20150379900 MODULAR, WIRELESS, DRUG SIMULANT INJECTION SENSOR SYSTEM AND METHODS OF EMPLOYING  
A device for monitoring the position of a plunger member slidingly engaged with a main body of a syringe includes a housing structured to be selectively coupled to the main body in a readily...
US20150377867 MULTIPARAMETRIC METHOD FOR ASSESSING IMMUNE SYSTEM STATUS  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
US20150376595 Method for Engineering Three-Dimensional Synthetic Vascular Networks Through Mechanical Micromachining and Mutable Polymer Micromolding  
The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a...
US20150374736 URIDINE DIPHOSPHATE COMPOUNDS AS MOBILIZERS OF HEMATOPOIETIC PROGENITOR CELLS  
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for...
US20150374633 THERMORESPONSIVE HYDROGEL CONTAINING POLYMER MICROPARTICLES FOR NONINVASIVE OCULAR DRUG DELIVERY  
A method for sustained delivery of an agent to an ocular organ in a subject, comprising topically delivering to the ocular surface a liquid thermoresponsive hydrogel comprising agent-loaded...
9221888 Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides  
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ No. 2, RRRGDEDE(SSD)nDEG indicated by SEQ No. 3, and LKKLKKLDEDE(SSD)nDEG...
9220711 Compounds for the treatment of pathologies associated with aging and degenerative disorders  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
US20150371023 USAGE MODELING  
Embodiments of techniques or systems for usage modeling or gesture based authentication are provided herein. Actions of a user may be captured, classified, and utilized to generate an...
US20150367033 INJECTABLE PERIPHERAL NERVE SPECIFIC HYDROGEL  
The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following...
US20150366913 Biologic Scaffold For Prevention of Pulmonary Fibrosis  
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived...
9217000 Targeted nitroxide agents  
A compound having a structure of:
9216976 Targeted nitroxide agents  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20150361319 COMPOSITIONS FOR PREVENTION OF ICE BUILD-UP  
A composition comprising a silicone oil or fluorosilicone fluid infused in a cross-linked silicone resin matrix. The silicone oil or fluorosilicone fluid may comprise a linear or branched...
US20150360698 SYSTEMS AND METHOD FOR DRIVING EVALUATION AND TRAINING  
A system for evaluation of an operator of a vehicle including a steering system under observation of an evaluator within the vehicle includes a steering sensor system adapted to measure...