Patents and Patent Applications from University of Pittsburgh


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US20150297578 Selective Targeting Agents for Mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20150291534 COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS  
Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef...
US20150290420 METHODS, DEVICES AND SYSTEMS FOR TREATING INSOMNIA BY INDUCING FRONTAL CEREBRAL HYPOTHERMIA  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20150290308 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
9156888 Antibody molecules  
The present invention provides murine monoclonal antibody molecules that bind to Merkel cell carcinoma virus (MCV) polypeptides.
US20150283109 LIPASE INHIBITORS FOR THE TREATMENT OF PANCREATITIS AND ORGAN FAILURE  
The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor....
US20150276983 EFFICIENT WHITE LIGHT SCATTERING PHOTONIC BANDGAP CRYSTAL  
A photonic bandgap crystal or photonic bandgap crystal material comprising a self-assembled crystalline colloidal array (CCA) of monodisperse spherical particles having a face-centered-cubic (fcc)...
9144598 Reverse thermal gels and their use in cell therapy  
Methods are disclosed herein for increasing survival of transplanted cells, either in vitro or in vivo. In additional embodiments, methods are disclosed for treating a subject with a spinal cord...
US20150268448 IMAGING LENS  
An imaging lens includes a first lens group having positive refractive power; a second lens group having positive refractive power; and a third lens group having negative refractive power,...
US20150265677 RECRUITMENT OF MENSENCHYMAL CELLS USING CONTROLLED RELEASE SYSTEMS  
The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the...
US20150265626 METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
9139622 Citrobacter freundii antibacterial agents and their use  
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
US20150258185 INTERLEUKIN-13 RECEPTOR ALPHA 2 PEPTIDE-BASED BRAIN CANCER VACCINES  
Provided herein are interleukin-13 receptor α2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need...
US20150258103 USE OF RESAZURIN, OR ANALOGS THEREOF, FOR ANTIBACTERIAL THERAPY  
A method for treating infection by bacteria in a subject, comprising administering to the subject a therapeutically effective amount of resazurin or a resazurin analog, or a pharmaceutically...
9134328 Methods of using benzothiazole derivative compounds and compositions  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
9132199 Reverse thermal gels and uses therefor  
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower...
9132193 Use of Slurp1 as an imunomodulatory molecule in the ocular surface  
Methods for treating inflammation are disclosed, such as for treating ocular inflammation. In some embodiments, the ocular inflammation is inflammation of an ocular surface, such as keratitis. The...
US20150251106 NANO SEEDING TOOLS TO GENERATE NANOMETER SIZE CRYSTALLIZATION SEEDS  
A kit and a method for using the kit to generate nanoseeds from protein nanocrystals and aggregates is disclosed. The method comprises mixing a plurality of beads with a protein nanocrystal or...
US20150250809 NOVEL TLR4 INHIBITORS FOR THE TREATMENT OF HUMAN INFECTIOUS AND INFLAMMATORY DISORDERS  
The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In...
9131527 Wireless systems having multiple electronic devices and employing simplified fabrication and matching, and associated methods  
A means and method to connect multiple IC chips to a single apparatus where the IC chips may function as a passive system or network in space. The collection of antennae and coupled near field...
9130580 Low-power pulse width encoding scheme and counter-less shift register that may be employed therewith  
A method of decoding an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
9127016 Small molecule inhibitors of Dusp6 and uses therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
9125891 Lymph nodes as a site for regeneration  
Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
US20150247083 PROPPANTS FOR HYDROCARBON RECOVERY  
A method of hydraulic fracturing in a subterranean formation includes injecting a fluid including a proppant into the subterranean formation, wherein the proppant includes a material adapted to...
US20150246939 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury  
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use...
US20150246128 CONDUCTIVE POLYMER GRAPHENE OXIDE COMPOSITE MATERIALS  
A composition includes a composite material including at least one conducting polymer doped with graphene oxide and at least one agent immobilized at least one of (i) on graphene oxide extending...
9121009 Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150241415 EVALUATING RENAL INJURY USING HYALURONIC ACID  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients. In particular, the invention relates to...
US20150240317 FUNCTIONAL GENOMICS SCREENING PLATFORM FOR HEAD AND NECK CANCER  
The present invention relates to HPV-positive as well as HPV-negative screening platforms that are highly serum-dependent, for use as HNSCC models. These HNSCC models die reproducibly in...
9115357 Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
9114109 Five-coordinate neuroglobin and use thereof as a blood substitute  
Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild...
US20150232526 USE OF RELAXIN TO TREAT ATRIAL FIBRILLATION  
Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
US20150231271 FORMULATIONS AND CARRIER SYSTEMS INCLUDING FARNESYLTHIOSALYCYLIC MOITIES  
A method of forming or creating a formulation for a compound to be delivered includes creating a carrier agent by conjugating at least one hydrophobic domain or hydrophobic compound with at least...
US20150231180 TRABECULAR MESHWORK STEM CELLS  
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and...
US20150230453 COMPOSITIONS AND METHODS FOR ORGAN PRESERVATION  
Disclosed herein are solutions for use with machine perfusion of one or more organs. In some embodiments, the solutions comprise acellular cross-linked hemoglobin in a physiologically acceptable...
9107892 Identification of a novel retrovirus in patients with benign prostatic hyperplasia  
Methods for producing an immune response to a benign prostatic hyperplasia (BPH) virus are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
US20150216824 Treatment of Medium-Chain Acyl-CoA Dehydrogenase Deficiency  
The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can...
9096853 Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity  
A synthesized siRNA molecule having the sense strand with one or more uridine bases replaced by one or more respective nucleoside analogs, such as 5-fluoro-2′-deoxyuridine (FdU).
9096661 Monoclonal antibodies for CSPG4 for the diagnosis and treatment of basal breast carcinoma  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20150209207 SEATING FUNCTION MONITORING AND COACHING SYSTEM  
A wheelchair system includes a wheelchair including at least one adjustable seating function, a sensor system in operative connection with the wheelchair which includes at least one sensor to...
US20150208950 Arterial and Venous Oxygenation Method and Apparatus  
Methods and apparatuses for an oxygen consumption monitoring system are disclosed herein. In one embodiment, an oxygen consumption monitoring system is disclosed. The oxygen consumption monitoring...
US20150208923 Non-Invasive Monitoring of Tissue Mechanical Properties  
Methods and apparatuses for a tissue mechanical property monitoring system are disclosed herein. In one embodiment, a tissue mechanical property monitoring system is disclosed. The tissue...
9089400 Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20150204728 SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY  
Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within...
9084722 Biologic scaffold for prevention of pulmonary fibrosis  
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived...
US20150198440 PATHWAY MEASUREMENT DEVICES, SYSTEMS AND METHODS  
A pathway measurement system hereof includes a rigid frame and a mobility system attached to the frame. The mobility system includes at least one movable element which is adapted to contact a...
US20150197793 GAMMA-PNA MINIPROBES FOR FLUORESCENT LABELING  
A category of γPNA miniprobes and chimeric γPNA probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes...
9080216 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20150194066 MEDICAL DEVICE TRAINING SYSTEMS AND METHODS OF USING  
A smart peripheral device for use in a medical training system. The medical training system having a processing device, software to emulate aspects of a medical device and a display in...
US20150191786 Genetic Polymorphisms Associated With Advanced Lung Diseases  
The present invention relates to methods and compositions that may be used to predict the risk of an individual, for example a smoker, for developing chronic obstructive pulmonary disease...