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Patents and Patent Applications from University of Pittsburgh


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8466131 Ligands specific for cannabinoid receptor subtype 2  
A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or...
8466123 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
8465727 Biomarkers for the diagnosis of ALS  
Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative...
US20130149712 FOLLISTATIN-LIKE PROTEIN-1 AS A BIOMARKER FOR INFLAMMATORY DISORDERS  
The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated...
US20130149290 Engineered Dendritic Cells and Uses for the Treatment of Cancer  
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12...
US20130146821 REDOX STIMULATED VARIABLE-MODULUS MATERIAL  
A material having a first non-zero elastic modulus capable of reversibly changing the first non-zero elastic modulus to a second non-zero elastic modulus in response to a redox reaction occurring...
8461993 Wireless systems having multiple electronic devices and employing simplified fabrication and matching, and associated methods  
A means and method to connect multiple IC chips to a single apparatus where the IC chips may function as a passive system or network in space. The collection of antennae and coupled near field...
8460637 Reconstitutable microsphere compositions useful as ultrasonic contrast agents  
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...
8460269 Directed cell-based therapy using microbubble tagged cells  
The disclosed technology describes compositions and methods useful for providing cell based therapy. For example, one embodiment of cell based therapy involves the regeneration of injured tissue...
US20130131278 MODIFICATION OF SURFACES WITH POLYMERS  
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
US20130129663 REVERSE THERMAL GELS AND USES THEREFOR  
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower...
8445261 Apparatus for holding cells  
An apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired...
US20130118904 SEPARATION OF PARTICLES USING MULTIPLEXED DIELECTROPHORESIS  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. Time-multiplexed dielectrophoresis can be employed by cycling between two...
8442630 Automated assessment of atrioventricular and ventriculoatrial conduction  
A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An...
8440993 Ultrahigh density patterning of conducting media  
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
8440992 Ultrahigh density patterning of conducting media  
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
US20130116575 IMPLANTABLE DOPPLER BLOOD FLOW MONITOR AND DOPPLER PROBE  
A Doppler blood flow monitoring system comprises a sensor cuff capable of being secured around an exterior surface of a patient's vessel, at least one transducer attached to the sensor cuff for...
8435948 Methods for inhibiting osteoclastic bone resorption and bone loss comprising administration of an anti-FSH or anti-FSHR antibody  
The invention discloses compositions and methods for decreasing osteoclast which are useful for the treatment of a variety of bone loss disorders.
US20130102662 USE OF INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS AND NITRIC OXIDE SCAVENGERS TO INHIBIT POST-TRAUMATIC IMMUNODEPRESSION  
The present invention relates to methods and compositions that inhibit the effects of nitric oxide for inhibiting post-traumatic immunodepression. It is based, at least in part, on the discovery...
US20130102626 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20130101676 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
8426146 Multiparameteric method for assessing immune system status  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
8425583 Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20130096186 IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR RETARGETING TO NOVEL NON-HSV RECEPTORS  
The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV vectors of the present invention can...
US20130095566 Flux Balance Analysis With Molecular Crowding  
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
US20130095516 Light Refraction Imaging to Measure Liquid Volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
8421274 Wireless energy transfer system  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load....
US20130090516 Local Anesthesia By Magnet-Directed Concentration of Nanoparticle Conjugated Anesthetic  
Methods and formulations for induction of local anesthetic effects employing magnetic nanoparticles conjugated to anesthetic molecules. Magnetic nanoparticle-local anesthetic conjugates may be...
US20130085511 Novel Tactile Feedback System for Robotic Surgery  
Apparatuses and methods for the haptic sensation of forces at a remote location. Groups of MEMS-based pressure sensors are combined into sensor arrays. In some embodiments, the pressure sensors are...
US20130081786 VARIABLE THERMAL INSULATION  
A device for selectively controlling the passage of thermal energy therethrough by selectively varying the overall thermal conductivity of the device comprises a structure having at least one...
US20130079241 Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse  
The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid...
US20130077046 NORMALIZATION OF RETINAL NERVE FIBER LAYER THICKNESS MEASUREMENTS MADE BY TIME DOMAIN-OPTICAL COHERENCE TOMOGRAPHY  
A scan location matching (SLM) method identifies conventional time domain optical coherence tomography (TD-OCT) circle scan locations within three-dimensional spectral domain OCT scan volumes. A...
8404213 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
US20130072790 SELECTION AND OPTIMIZATION FOR CARDIAC RESYNCHRONIZATION THERAPY  
Systems and methods for imaging and analyzing a patient heart are described. Imaging can be performed with a variety or combination of methods, including single photon emission computed tomography,...
US20130072547 USE OF TOLL-LIKE RECEPTOR-9 AGONISTS, TOLL-LIKE RECEPTOR-4 ANTAGONISTS, AND/OR NUCLEAR OLIGOMERIZATION DOMAIN-2 AGONISTS FOR THE TREATMENT OF PREVENTION OF TOLL-LIKE RECEPTOR-4-ASSOCIATED DISORDERS  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis...
US20130071930 POLYESTERS, METHODS OF MAKING POLYESTERS AND USES THEREFOR  
Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue...
US20130071419 UNIVERSAL DENGUE VIRUS SEQUENCES AND METHODS OF USE  
Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments (such...
8398576 Removal of contrast agents from blood  
The invention provides a system and a method for removal of contrast from blood. In one aspect, the invention provides a catheter for removal of contrast from the veins that drain the cerebral...
US20130059912 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its m...
US20130058991 MATRICRYPTIC ECM PEPTIDES FOR TISSUE RECONSTRUCTION  
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in...
US20130058910 DECONTAMINATION OF CHEMICAL AND BIOLOGICAL AGENTS  
A system includes at least one oxidase. at least one haloperoxidase; at least a first polymer including groups exhibiting nucleophilic activity for organophosphorus compounds, and a source of...
US20130058891 Kexin-Derived Vaccines to Prevent or Treat Fungal Infections  
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat...
8391375 Wireless autonomous device data transmission  
A method of communicating information from a wireless autonomous device (WAD) to a base station. The WAD has a data element having a predetermined profile having a total number of sequenced...
8389493 Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
US20130053319 CHEMOKINE DERIVED PEPTIDES AND USES FOR CHRONIC WOUND AND ANGIOGENESIS INHIBITION TREATMENTS  
Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of...
US20130048950 ON-DEMAND NANOELECTRONICS PLATFORM  
A reconfigurable device includes a first insulating layer, a second insulating layer, and a nanoscale quasi one- or zero-dimensional electron gas region disposed at an interface between the first...
US20130045164 AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
8376463 User adjustable wheelchair backrest mounting hardware  
Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of...
US20130040397 DETECTION OF HYDROGEN SULFIDE GAS USING CARBON NANOTUBE-BASED CHEMICAL SENSORS  
A method for preparing carbon allotrope based sulfide detectors comprising first functionalizing a carbon allotrope, such as a single-walled carbon nanotubes or graphene, with a solution of a...
US20130040283 GRAPHENE COMPOSITION, METHOD OF FORMING A GRAPHENE COMPOSITION AND SENSOR SYSTEM COMPRISING A GRAPHENE COMPOSITION  
A method of forming a composition includes oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide.