Patents and Patent Applications from University of Pittsburgh


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US20160022805 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR HUMAN AND AVIAN H5N1 INFLUENZA  
Described herein is the generation of optimized H5N 1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides...
US20160022779 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
US20160020382 OXIDE INTERFACE DISPLAYING ELECTRONICALLY CONTROLLABLE FERROMAGNETISM  
A structure includes an electronically controllable ferromagnetic oxide structure that includes at least three layers. The first layer comprises STO. The second layer has a thickness of at least...
9237945 Bioerodible wraps and uses therefor  
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be...
US20160011167 METHODS AND APPARATUS TO MEASURE CONSTITUTIVE RELATIONS AND FIBER ORIENTATION OF SOFT TISSUES  
The systems and methods provided herein relate to the performance of inverse reconstruction algorithms from ultrasound radiofrequency data and stress-strain data. These systems and methods can be...
US20160008394 INORGANIC NITRITE TO IMPROVE CARDIOPULMONARY HEMODYNAMICS  
Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. Sodium nitrite is a naturally occurring compound that is commonly used as...
US20160008127 PROSTHETIC IMPLANT FOR MEDIALIZATION THYROPLASTY  
Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the...
9235465 Recursively determined invertible set approach to correct multiple stuck-at faults in rewritable memory  
Systems and methods are disclosed that facilitate storage and retrieval of data to/from memory with permanent faults. Permanent “stuck at” faults, associated with individual bits, interfere with...
9234026 Apolipoprotein E polypeptides and their use  
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as...
9234008 Computationally optimized broadly reactive antigens for H3N2, H2N2, and B influenza viruses  
Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA...
US20160000554 APPARATUS AND METHOD FOR REGENERATION OF LIGAMENTS AND TENDONS  
A method for repairing a ligament or tendon, the method comprising: passing one or more sutures through and/or around each respective end of a completely or partially torn ligament or tendon;...
US20150379900 MODULAR, WIRELESS, DRUG SIMULANT INJECTION SENSOR SYSTEM AND METHODS OF EMPLOYING  
A device for monitoring the position of a plunger member slidingly engaged with a main body of a syringe includes a housing structured to be selectively coupled to the main body in a readily...
US20150377867 MULTIPARAMETRIC METHOD FOR ASSESSING IMMUNE SYSTEM STATUS  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
US20150376595 Method for Engineering Three-Dimensional Synthetic Vascular Networks Through Mechanical Micromachining and Mutable Polymer Micromolding  
The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a...
US20150374736 URIDINE DIPHOSPHATE COMPOUNDS AS MOBILIZERS OF HEMATOPOIETIC PROGENITOR CELLS  
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for...
US20150374633 THERMORESPONSIVE HYDROGEL CONTAINING POLYMER MICROPARTICLES FOR NONINVASIVE OCULAR DRUG DELIVERY  
A method for sustained delivery of an agent to an ocular organ in a subject, comprising topically delivering to the ocular surface a liquid thermoresponsive hydrogel comprising agent-loaded...
9221888 Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides  
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ No. 2, RRRGDEDE(SSD)nDEG indicated by SEQ No. 3, and LKKLKKLDEDE(SSD)nDEG...
9220711 Compounds for the treatment of pathologies associated with aging and degenerative disorders  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
US20150371023 USAGE MODELING  
Embodiments of techniques or systems for usage modeling or gesture based authentication are provided herein. Actions of a user may be captured, classified, and utilized to generate an...
US20150367033 INJECTABLE PERIPHERAL NERVE SPECIFIC HYDROGEL  
The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following...
US20150366913 Biologic Scaffold For Prevention of Pulmonary Fibrosis  
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived...
9217000 Targeted nitroxide agents  
A compound having a structure of:
9216976 Targeted nitroxide agents  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20150361319 COMPOSITIONS FOR PREVENTION OF ICE BUILD-UP  
A composition comprising a silicone oil or fluorosilicone fluid infused in a cross-linked silicone resin matrix. The silicone oil or fluorosilicone fluid may comprise a linear or branched...
US20150360698 SYSTEMS AND METHOD FOR DRIVING EVALUATION AND TRAINING  
A system for evaluation of an operator of a vehicle including a steering system under observation of an evaluator within the vehicle includes a steering sensor system adapted to measure...
9212207 Computationally optimized broadly reactive antigens for H5N1 and H1N1 influenza viruses  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
9211519 Methods to prepare patchy microparticles  
A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self-assembled microparticles with a...
9211212 Apparatus and method for modulating sleep  
Apparatuses and methods to enhance sleep, reduce sleep onset latency, extend sleep duration and/or increasing the duration of deeper sleep stages relative to stage 1 sleep. In general, these...
9206233 Templates for controlling synthesis of nanoparticles into discrete assemblies  
An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.
US20150344971 METHOD FOR DIAGNOSIS, PROGNOSIS AND DETERMINATION OF TREATMENT FOR CUTANEOUS T-CELL LYMPHOMA  
The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX,...
9200322 Biomarkers for acute ischemic stroke  
The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke...
9200035 Bifunctional compounds  
A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl...
9199003 Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
9198621 Method, apparatus and system for food intake and physical activity assessment  
Electronic systems, devices and methods are provided to accurately measure both food intake and physical activity in a subject. A device is provided to be placed on a subject which records video...
US20150335807 REMOVAL OF CARBON DIOXIDE VIA DIALYSIS  
A method of reducing the concentration of carbon dioxide in blood plasma includes removing blood from a patient and treating or processing at least blood plasma of the blood by flowing the blood...
US20150335707 USE OF SLURP1 AS AN IMUNOMODULATORY MOLECULE IN THE OCULAR SURFACE  
Methods for treating inflammation are disclosed, such as for treating ocular inflammation. In some embodiments, the ocular inflammation is inflammation of an ocular surface, such as keratitis. The...
9193796 Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
US20150330975 Urinary Biomarkers For Predicting Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
US20150327835 METHOD AND APPARATUS TO DETECT LIPID CONTENTS IN TISSUES USING ULTRASOUND  
A method for quantifying an amount of fat contained in a liver or other tissue of a subject in vivo includes varying the temperature of a target area in a subject, imaging thermal strain of the...
9187528 Inhibitors of Nox1  
The present invention relates to inhibitors of Nox1-dependent reactive oxygen species production and their use in the treatment of disorders associated with reactive oxygen species, such as...
9187441 p53-Mdm2 antagonists  
Novel p53-Mdm2 antogonists that conform to Formula I or to Formula II: where the prescribed substituent groups are defined, are useful in treating or preventing cancer. In particular, the...
9186408 Nitrated-fatty acids modulation of type II diabetes  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its...
US20150325311 LOW-POWER PULSE WIDTH ENCODING SCHEME AND COUNTER-LESS SHIFT REGISTER THAT MAY BE EMPLOYED THEREWITH  
A method of decoding, an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
US20150322202 METHODS OF ELECTROSPINNING AND COMPOSITIONS MADE THEREFROM  
Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a...
9180167 Activators of CXCR3 for the treatment of angiopathies of the eye  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
US20150315649 METHOD FOR DIAGNOSING AND ASSESSING RISK OF PANCREATITIS USING GENETIC VARIANTS  
The present application discloses methods for predicting the risk of developing, or the presence of, recurrent acute pancreatitis and/or chronic pancreatitis, in a subject, by identifying the...
US20150314059 EXTRACORPOREAL AMBULATOR ASSIST LUNG  
A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow...
US20150310254 SYSTEM AND METHOD FOR AUTOMATED IDENTIFICATION OF ABNORMAL CILIARY MOTION  
A method of classifying ciliary motion includes receiving digital video data representing the ciliary motion generated by an image capture device, wherein the digital video data includes a...
US20150307655 Polyesters, Methods of Making Polyesters and Uses Therefor  
Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue...
US20150307582 ENGINEERED RECEPTORS AND THEIR USE  
Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions...