Patents and Patent Applications from University of Pittsburgh


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9561497 Non-noble metal based electro-catalyst compositions for proton exchange membrane based water electrolysis and methods of making  
The invention provides electro-catalyst compositions for an anode electrode of a proton exchange membrane-based water electrolysis system. The compositions include a noble metal component selected...
US20170028101 Biodegradable, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy  
Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C....
US20170028034 MUTANT HUNTINGTIN-MEDIATED PROTEIN DYSFUNCTION  
The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing,...
9556252 Use of endostatin peptides for the treatment of fibrosis  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
9555095 Computationally optimized broadly reactive antigens for H5N1 and H1N1 influenza viruses  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
9554777 Methods and apparatuses for measuring tissue stiffness changes using ultrasound elasticity imaging  
A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located...
US20170022264 THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGEN  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
US20170022237 CATALYTIC GLYCOSYLATION WITH DESIGNER THIOGLYCOSIDE AND NOVEL PROTECTING GROUPS FOR SAME AND FOR SYNTHESIS OF OLIGOSACCHARIDES  
A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether...
9551720 Urine biomarkers for prediction of recovery after acute kidney injury: proteomics  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal...
9549980 Methods of treating necrotizing enterocolitis by administering nuclear oligomerization domain-2 agonists,TLR9 agonists and TLR4 antagonists  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic...
US20170014548 MAGNESIUM/POLYMER COMPOSITE-CONTAINING SCAFFOLDS TO ENHANCE TISSUE REGENERATION  
The invention relates to magnesium-polymer composites, methods for their preparation and applications for their use. The composites include a combination of magnesium particles and polymer matrix....
US20170014349 TREATING SOFT TISSUE VIA CONTROLLED DRUG RELEASE  
Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need...
US20170014220 INTRA-ORAL PROSTHESES AND OTHER ANATOMICAL PROSTHESES  
Described herein are intra-oral prostheses that can help replace or augment the function of the native tongue, such as to assist with swallowing. Disclosed prostheses can provide mechanical force,...
9546144 Bifunctional compounds  
A compound having the formula: wherein X is S, SO or SO2;one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl...
US20170009245 ENGINEERED CYTOKINE- AND CHEMOKINE-EXPRESSING CANDIDA ALBICANS STRAINS AND METHODS OF USE  
Recombinant nucleic acid constructs for expression of heterologous cytokines or chemokines in C. albicans, and genetically modified C. albicans strains comprising the recombinant nucleic acid...
9539338 Polymer-based protein engineering methods to rationally tune enzyme activity, pH-dependence and stability  
Using a novel water-soluble, active ester amide-containing functionalized controlled radical polymerization initiator, stimuli responsive polymers have been grown from the surface of a protein,...
9538940 Intelligent algorithms for tracking three-dimensional skeletal movement from radiographic image sequences  
Systems and methods are disclosed that improve conventional tracking and modeling methods for determining three-dimensional bone motion from sequences of radiographic images. These enhancements...
US20170004276 BIOMARKER TEST FOR ACUTE CORONARY SYNDROME  
The present invention relates to biomarker signatures and associated methods for identifying patients that are not likely to manifest significant coronary artery disease. It is based, at least in...
US20170002050 EPHA2 T-CELL EPITOPE AGONISTS AND USES THEREFORE  
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative...
US20170001949 NOVEL CANNABINOID RECEPTOR 2 (CB2) INVERSE AGONISTS AND THERAPEUTIC POTENTIAL FOR MULTIPLE MYELOMA AND OSTEOPOROSIS BONE DISEASES  
Cannabinoid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are independently H, alkyl, or alkenyl; R3...
US20170000852 GOBLET CELL REPLACEMENT THERAPY  
Described herein is the finding that activators of CXCR3, such as proteins that bind CXCR3 (e.g., IP-9, IP-10 and PF4), enhance the density of goblet cells in the eye. Goblet cells in the...
9532999 TLR4 inhibitors for the treatment of human infectious and inflammatory disorders  
The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In...
US20160376666 FUSION GENES ASSOCIATED WITH PROGRESSIVE PROSTATE CANCER  
The present invention relates to methods and compositions for determining whether a subject having prostate cancer is at greater risk of developing progressive disease, and methods of treating the...
9523120 Method of amplifying a nucleic acid  
A nucleic acid amplification method is provided, along with kits useful in performing the amplification method.
9522163 Methods of treating hepatitis  
The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
US20160361464 Biomimetic Hydrogel Scaffolds and Related Methods  
Provided herein are methods of making a biomimetic hydrogel scaffold comprising a polycation and a polyanion. Also provided are anisotropic biomimetic hydrogel scaffold compositions suitable for...
US20160361443 Ultrasound Molecular Imaging With Targeted Biocompatible Microbubbles  
The present invention is related to cardiovascular contrast agents. In particular, compositions and methods for ultrasound cardiovascular contrast agents useful for molecular imaging and/or...
US20160361387 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
US20160361319 METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
US20160355459 Small Molecule Inhibitors of Dusp6 and Uses Therefor  
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The...
US20160354401 URIDINE DIPHOSPHATE COMPOUNDS AS MOBILIZERS OF HEMATOPOIETIC PROGENITOR CELLS  
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobilizing compound (for...
9514513 Establishing compatibility between two- and three-dimensional optical coherence tomography scans  
Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional...
9511074 Methods of treating disorders associated with protein polymerization  
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine,...
9510932 Biodegradable metal alloys  
The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components,...
9506032 Engineered biological pacemakers  
Biological pacemakers engineered to intrinsically generate rhythmic excitations are disclosed. In addition, methods of producing the biological pacemakers are disclosed. Methods of treating or...
9504424 Skin screw electrodes  
Electrodes providing excellent recording and physical stability. Electrodes are disclosed that may include a plurality of small teeth that possess a novel design shape and orientation. The shallow...
US20160339048 URIDINE DIPHOSPHATE COMPOUNDS AS MOBILIZERS OF HEMATOPOIETIC PROGENITOR CELLS  
The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for...
US20160339002 PEDIATRIC ORAL SUSPENSION FORMULATIONS OF AMOXICILLIN AND CLAVULANATE POTASSIUM AND METHOD FOR USING SAME  
The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is present in an amount equal to or less than...
US20160338984 PARTICLE FORMULATIONS OF ALL-TRANS RETINOIC ACID AND TRANSFORMING GROWTH FACTOR BETA FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS  
Particle formulations are disclosed that include polymeric particles containing a small molecule drug and a high molecular weight therapeutic protein. Methods of making and using the particle...
9499791 Skeletal muscle augmentation utilizing muscle-derived progenitor compositions, and treatments thereof  
The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following...
9498221 Implantable medical devices having double walled microspheres  
An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
US20160332943 CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY  
The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high...
US20160331833 Method of Enhancing KSHV LANA1 Immunogenicity  
An immunogenically-enhanced Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (“KSHV LANA1”) polypeptide and related methods of eliciting an immune response to KSHV LANA1...
9492450 Inhibition of dynamin related protein 1 to promote cell death  
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i)...
9492408 Protection from chemical-induced acute lung injury  
Methods are provided herein for treating an individual having a disease, disorder or condition affecting the lungs, wherein said disease, disorder, or condition of the lung is an acute lung...
9492313 Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders  
A method and device for treating neurological disorders involving the application of noninvasive, regional brain thermal stimulation to a region of a patient's head associated with a subject...
US20160330551 SYSTEM AND METHOD FOR ENHANCING THE BINAURAL REPRESENTATION FOR HEARING-IMPAIRED SUBJECTS  
A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated...
US20160327540 Light Refraction Imaging to Measure Liquid Volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
US20160325016 Biohybrid Composite Scaffold  
A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs....
9490028 Low-power pulse width encoding scheme and counter-less shift register that may be employed therewith  
A method of decoding, an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...