Patents and Patent Applications from University of Pittsburgh


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US20150010832 CATHODES AND ELECTROLYTES FOR RECHARGEABLE MAGNESIUM BATTERIES AND METHODS OF MANUFACTURE  
The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g.,...
US20150010510 Bone-Derived Extra Cellular Matrix Gel  
Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
8927521 Cyclic adenosine monophosphates for reducing the formation of adhesions  
Provided herein are methods of reducing adhesion formation in a subject, for example, post-surgical abdominal and pelvic adhesions. The methods include the step of administering to the subject in...
8927231 Separatome-based protein expression and purification platform  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
8927003 Extracellular matrix based gastroesophageal junction reinforcement device  
Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part...
US20150005613 METHOD AND APPARATUS TO ENHANCE LIGHT ILLUMINATING INTENSITY AND DIFFUSIVITY  
Photoacoustic probes include reflective surfaces situated to redirect scattered or reflected optical radiation from a specimen surface back to the specimen. A reflective coating can reflect probe...
US20150005607 BIOMIMETIC COATING FOR NEURAL IMPLANTS  
Disclosed herein are neural probes comprising an L1 polypeptide functional fragment thereof on the exterior surface of the probe, devices including such electrodes, and methods of their use. The...
8923786 Method of controlling RF transmissions to mitigate interference with critical care medical equipment  
Various methods of mitigating RF interference with one or more critical care medical devices is provided, wherein a predetermined threshold energy acceleration value is associated with the one or...
8922065 Wireless energy transfer system  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a...
8920764 Graphene composition, method of forming a graphene composition and sensor system comprising a graphene composition  
A method of forming a composition includes oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide.
US20140378444 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20140377213 WET-ELECTROSPUN BIODEGRADABLE SCAFFOLD AND USES THEREFOR  
A cell growth matrix is provided that comprises a biodegradable elastomeric polymer electrodeposited concurrently with a sprayed or electrosprayed liquid that is a physiological solution or which...
US20140375172 FLEXIBLE MOLECULAR PIEZOELECTRIC DEVICE  
A piezoelectric material, comprising: a piezoelectric self-assembling monolayer of oligopeptides; a conductive surface; and a substrate, wherein the conductive surface is located between the...
US20140371574 NONCONTACT ELECTROPHYSIOLOGICAL MEASUREMENT AND IMAGING OF THE HEART  
Method and system for noncontact electrophysiologic imaging of the heart. The methods may employ the magnetization and its relaxation-based measurements, sensitive or specifically sensitized to...
US20140371259 COMPOUNDS AND METHODS FOR INHIBITION OF AP ENDONUCLEASE-1/REDOX FACTOR-1 (HAPE1) ACTIVITY  
A method for treating a neoplasm in a subject, comprising co-administering to the subject a therapeutically effective amount of an anticancer agent and a substituted...
US20140371235 SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER  
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a...
US20140371112 Method and Apparatus for Holding Cells  
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown,...
US20140370495 RECOMBINANT MYCOBACTERIOPHAGES FOR DELIVERY OF NUCLEIC ACIDS OF INTEREST INTO MYCOBACTERIA  
Methods are provided for detecting mycobacteria in a sample, including clinical samples. Methods are also provided for determining susceptibility of mycobacterial strains to known or potential...
8911707 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
8911090 System for at-home eye movement monitoring  
An apparatus for monitoring eye movement in a patient, includes a frame structured to be worn on the head of the patient. An infrared illumination device structured to illuminate an eye of the...
8911089 Normalization of retinal nerve fiber layer thickness measurements made by time domain-optical coherence tomography  
A scan location matching (SLM) method identifies conventional time domain optical coherence tomography (TD-OCT) circle scan locations within three-dimensional spectral domain OCT scan volumes. A...
US20140363801 MEDICAL TRAINING SYSTEM AND METHOD OF EMPLOYING  
A medical training method includes generating an image of a first level of anatomical structures, displaying the image in a correct registration in a first display area on the surface of a portion...
8906905 Methods of treating disorders associated with protein polymerization  
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine,...
US20140357549 NOVEL INHIBITORS OF NOX1  
The present invention relates to inhibitors of Nox1-dependent reactive oxygen species production and their use in the treatment of disorders associated with reactive oxygen species, such as...
US20140356445 Artificial Cell Constructs For Cellular Manipulation  
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20140356331 INJECTABLE CNS-DERIVED ECM FOR TISSUE RECONSTRUCTION  
Methods useful for preparing central nervous system (CNS) derived extracellular matrix (ECM) materials, including powders and gels are provided. Also provided are CNS ECM preparations prepared...
US20140353378 LOW-POWER PULSE WIDTH ENCODING SCHEME AND COUNTER-LESS SHIFT REGISTER THAT MAY BE EMPLOYED THEREWITH  
A method of decoding an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
US20140350527 "Self-Regulating Device for Modulating Inflammation"  
A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and...
US20140350472 DISSOLVABLE MICRONEEDLE ARRAYS FOR TRANSDERMAL DELIVERY TO HUMAN SKIN  
A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the...
US20140349298 PORTABLE, LOW POWER INSTRUMENT FOR THE OPTOELECTRONIC DETECTION OF PATHOGENS USING ISOTHERMAL NUCLEIC ACID AMPLIFICATION PROTOCOLS  
This invention relates to a portable, low power apparatus and method for detecting a pathogen of interest in a biological sample obtained from a patient. The apparatus includes a heated pathogen...
US20140348778 REVERSE THERMAL GELS AND THEIR USE IN CELL THERAPY  
Methods are disclosed herein for increasing survival of transplanted cells, either in vitro or in vivo. In additional embodiments, methods are disclosed for treating a subject with a spinal cord...
8895739 Acylation of hindered amines and functionalized bis-peptides obtained thereby  
Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable...
US20140342923 BIOMARKER TEST FOR ACUTE CORONARY SYNDROME  
The present invention relates to biomarker signatures and associated methods for identifying patients that are not likely to manifest significant coronary artery disease. It is based, at least in...
8889791 Thermoresponsive, biodegradable, elastomeric material  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room...
US20140335547 Marker Panels For Idiopathic Pulmonary Fibrosis Diagnosis And Evaluation  
The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other...
8883852 Radioprotective agents  
Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an...
8883755 Mitochondrial targeted RNA expression system and use thereof  
Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped,...
8883171 Computationally optimized broadly reactive antigens for influenza  
Described herein is the development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates. The optimized HA protein...
US20140331341 AUTOMATED HIGH-CONTENT LIVE ANIMAL DRUG SCREENING USING C. ELEGANS  
The present invention relates to methods and compositions for high content drug screening in C. elegans which may be used to identify compounds that treat disorders associated with protein...
US20140329702 METHOD OF AMPLIFYING A NUCLEIC ACID  
A nucleic acid amplification method is provided, along with kits useful in performing the amplification method.
US20140329256 Urinary Biomarkers For Predicting Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
8878596 Hierarchical single molecule switch based on stimulated internal cluster motion within a hollow molecular cage  
Systems and methods related to single molecule switching devices are disclosed. One example method can include the step of applying a tunneling current across a tunneling junction. The tunneling...
8877728 Genetic changes in ATM and ATR/Chek1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20140323343 BIOMARKERS FOR ASSESSING IDIOPATHIC PULMONARY FIBROSIS  
Disclosed are methods are kits for evaluating predicting whether an individual IPF has slowly or rapidly progressive IPF.
US20140323322 METHOD AND APPARATUS FOR CHEMICAL SENSING USING 2D PHOTONIC CRYSTAL ARRAYS  
A chemical sensor comprising: a hydrogel layer, comprising one or more molecular recognition agents and a 2DPC self-assembling array; and a mirror layer. A method for analyzing a sample or bodily...
US20140321798 OPTICAL SENSOR EMPLOYING A REFRACTIVE INDEX ENGINEERED METAL OXIDE MATERIAL  
An optical sensor device includes an optical waveguide portion having a core, the core having a first refractive index, and a functional material layer coupled to the optical fiber portion, the...
US20140318990 pH SENSOR SYSTEM AND METHODS OF SENSING pH  
A system for measuring pH includes a substrate and a sensor medium on the substrate. The sensor medium includes at least one oxidized carbon nanostructure and optionally at least one composition...
8871831 Modification of surfaces with polymers  
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
US20140316242 QUANTIFIED INJURY DIAGNOSTICS  
A new and/or novel image analysis technique for quantitative assessment of motion-based testing for injury in a patient using universally available and affordable devices and techniques is...
US20140314816 STABILIZED STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFORE  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...