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Patents and Patent Applications from University of Pittsburgh


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8651782 Wheeled mobility device containment systems and occupant retention systems and methods of containing wheeled mobility devices and retaining occupants thereof  
A system to contain a wheeled mobility device in a vehicle, includes: a rearward opening to allow access by the wheeled mobility device by moving the wheeled mobility device forward relative to the...
US20140047569 Methods of Treating Disorders Associated with Protein Aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
US20140046208 COMPRESSIVE SAMPLING OF PHYSIOLOGICAL SIGNALS USING TIME-FREQUENCY DICTIONARIES BASED ON MODULATED DISCRETE PROLATE SPHEROIDAL SEQUENCES  
A method of sampling and reconstructing an original physiological signal obtained from a subject includes acquiring a number of samples of the original physiological signal, and generating a...
US20140045821 PROTEIN KINASE D INHIBITORS  
Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and...
US20140045678 NON-NOBLE METAL BASED ELECTRO-CATALYST COMPOSITIONS FOR PROTON EXCHANGE MEMBRANE BASED WATER ELECTROLYSIS AND METHODS OF MAKING  
The invention provides electro-catalyst compositions for an anode electrode of a proton exchange membrane-based water electrolysis system. The compositions include a noble metal component selected...
8647666 Administration of an adsorbent polymer for treatment of systemic inflammation  
The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene...
US20140037581 METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA  
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a...
US20140037542 NOVEL THERANOSTIC PLATFORM FOR TARGETED CANCER THERAPY AND DRUG DELIVERY MONITORING  
A compound that includes a quaterrylene dye moiety as core, and a dendrimeric shell. For example, the compound may comprise at least four dendronized polyamides covalently attached to a...
US20140030694 OXYGEN DEPLETION DEVICES AND METHODS FOR REMOVING OXYGEN FROM RED BLOOD CELLS  
An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed...
8637556 Linked Myc-max small molecule inhibitors  
Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of...
US20140025623 POSTERIOR PROBABILITY OF DIAGNOSIS INDEX  
The likelihood of a disorder can be determined using a variety of techniques. One or more exhibited symptoms may be obtained for a patient. The likelihood that each symptom will be exhibited for...
8632983 Biomarkers for pancreatic cancer and diagnostic methods  
Methods and related kits for differentiating pancreatic cancer from a benign pancreatic disease. The method includes assaying a patient biological sample for a total level of CA 19-9 antigen and...
US20140018317 TARGETED NITROXIDE AGENTS  
A compound having a structure of:
US20140017309 ENTERAL ADMINISTRATION OF SORBENT POLYMER FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATION  
The invention provides a method of ameliorating inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl...
8630810 Modeling wound healing  
Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue...
8628512 Emergency preservation and resuscitation methods  
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods...
US20140010811 ANTIBODIES TO ENDOPLASMIN AND THEIR USE  
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies,...
US20140010801 Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function  
This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or...
US20140005470 Graft Devices and Methods of Use  
A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a...
US20140005386 p53-Mdm2 ANTAGONISTS  
Novel p53-Mdm2 antogonists that conform to Formula I or to Formula II: where the prescribed substituent groups are defined, are useful in treating or preventing cancer. In particular, the compounds...
US20140004161 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
US20140004124 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20140001761 ADAPTIVE HYDROKINETIC ENERGY HARVESTING  
An energy harvester for producing useable energy from fluid motion of a fluid medium, the energy harvester comprising a support structure affixed directly or indirectly to a foundation or mounting;...
8617421 Lanthanide metal-organic frameworks and uses thereof  
Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new...
US20130345555 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position...
US20130345154 Gap Junction-Enhancing Agents for Treatment of Necrotizing Enterocolitis and Inflammatory Bowel Disease  
The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis (“NEC”) or inflammatory bowel disease (“IBD”) comprising adminis...
US20130344039 TH1-ASSOCIATED MICRORNAS AND THEIR USE FOR TUMOR IMMUNOTHERAPY  
Described herein is the identification of miRNAs (miRs) that are up-regulated in Th1 cells compared to Th2 cells (referred to herein as Th1-associated miRs). In particular, the miR-17-92 gene...
US20130338212 Genetic Changes In ATM And ATR/Chek1 As Prognostic Indicators In Cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20130337101 System and Method for Mandrel-Less Electrospinning  
A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for...
US20130336935 Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function  
This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or...
US20130335084 Cooling System for Magnetic Resonance Imaging Device Having Reduced Noise and Vibration  
A conduit for the transfer of a cooling medium is provided that may include a tube that has a length and a through aperture that extends through the entire length. The tube may have an inner...
8609850 Targeted nitroxide agents  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
8609110 Citrobacter freundii antibacterial agents and their use  
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
US20130332799 RECURSIVELY DETERMINED INVERTIBLE SET APPROACH TO CORRECT MULTIPLE STUCK-AT FAULTS IN REWRITABLE MEMORY  
Systems and methods are disclosed that facilitate storage and retrieval of data to/from memory with permanent faults. Permanent “stuck at” faults, associated with individual bits, interfere wit...
US20130331460 CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN  
Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for...
8603742 Methods for the diagnosis of fetal disease  
Methods are provided for detecting an aneuploidy in a fetus. These methods can be used to detect trisomy 13, 8 or 21, amongst other aneupoloidies. In some embodiments, the methods include...
8602998 Use of relaxin to increase arterial compliance  
The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present...
US20130323751 Urine Biomarkers For Prediction Of Recovery After Acute Kidney Injury: Proteomics  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal...
US20130323700 HYBRID PHYSICAL-VIRTUAL REALITY SIMULATION FOR CLINICAL TRAINING CAPABLE OF PROVIDING FEEDBACK TO A PHYSICAL ANATOMIC MODEL  
Systems and methods facilitating training in clinical procedures via mixed reality simulations are disclosed. Such a system can comprise a physical model and a virtual model of an anatomic region...
US20130323224 USE OF MYCOBACTERIUM SMEGMATIS TREHALOSE DIMYCOLATE HYDROLASE  
Methods are disclosed herein for treating an infection with a Mycobacterium infection. Methods are also disclosed for treating a Mycobacterium biofilm. The method include the use of trehalose...
US20130321064 HIERARCHICAL SINGLE MOLECULE SWITCH BASED ON STIMULATED INTERNAL CLUSTER MOTION WITHIN A HOLLOW MOLECULAR CAGE  
Systems and methods related to single molecule switching devices are disclosed. One example method can include the step of applying a tunneling current across a tunneling junction. The tunneling...
US20130317376 Electrocardiogram Reconstruction from Implanted Device Electrograms  
A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an...
US20130316959 USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
US20130316349 N-METHYLPURINE DNA GLYCOSYLASE AND POLYMERASE BETA AS BIOMARKERS FOR ALKYLATOR CHEMOTHERAPY POTENTIATION  
Described herein is the finding that polymerase β (Polβ) and N-methylpurine DNA glycosylase (MPG) can be used as biomarkers to evaluate the sensitivity of a subject to combination therapy that i...
US20130315857 Kexin-Derived Vaccines to Prevent or Treat Fungal Infections  
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat...
US20130309664 HEAT SHOCK PROTEINS AS AUTOANTIGENS  
The present invention relates to methods of diagnosing and/or determining a prognosis for various diseases, including lung diseases such as idiopathic pulmonary fibrosis, chronic obstructive lung...
US20130299773 LOW VOLTAGE NANOSCALE VACUUM ELECTRONIC DEVICES  
An electronic device including a first conducting layer, a second conducting layer, and an insulating layer provided between the conducting layers. At least one side wall extends from the first...
US20130299427 Urinary Biomarkers For Predicting Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
8580561 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
8580229 Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...