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Patents and Patent Applications from University of Pittsburgh


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US20130178788 ELECTROOSMOTIC CONVECTION-ENHANCED DELIVERY SYSTEM  
Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional...
US20130178158 WIRELESS SYSTEMS HAVING MULTIPLE ELECTRONIC DEVICES AND EMPLOYING SIMPLIFIED FABRICATION AND MATCHING, AND ASSOCIATED METHODS  
A means and method to connect multiple IC chips to a single apparatus where the IC chips may function as a passive system or network in space. The collection of antennae and coupled near field...
US20130177820 SILICON-CONTAINING COMPOSITIONS, METHODS OF THEIR PREPARATION, AND METHODS OF ELECTROLYTICALLY DEPOSITING SILICON ON A CURRENT CARRIER FOR USE IN LITHIUM ION BATTERY APPLICATIONS  
The invention relates to silicon-containing compositions, methods of preparing these compositions and methods of depositing amorphous silicon originating from these compositions onto substrates to...
8480588 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position...
US20130172388 NOVEL CANNABINOID RECEPTOR 2 (CB2) INVERSE AGONISTS AND THERAPEUTIC POTENTIAL FOR MULTIPLE MYELOMA AND OSTEOPOROSIS BONE DISEASES  
Cannabionid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are independently H, alkyl, or alkenyl; R3...
8476410 Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
US20130165877 AUGMENTED CHEST TUBE DRAINAGE SYSTEM AND METHOD WITH VOLUME SENSING, AUTOMATED ALERTS AND MESSAGING CAPABILITY  
Systems and methods that can augment conventional chest tube drainage canisters are discussed. One such system can monitor a chest tube drainage canister that collects fluid and includes a volume...
8471850 Image generating apparatus, method of generating image, program, and recording medium  
The present application generates an image in which a contour line is drawn about a tuned object A in a virtual three-dimensional space when a part of the tuned object A is overlapped by another...
US20130158662 Muscle Derived Cells For The Treatment Of Gastro-Esophageal Pathologies And Methods Of Making And Using The Same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20130156862 Extracellular Matrix-Derived Gels and Related Methods  
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as...
US20130156741 Bone Augmentation Utilizing Muscle-Derived Progenitor Compositions, And Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
8466131 Ligands specific for cannabinoid receptor subtype 2  
A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or...
8466123 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
8465727 Biomarkers for the diagnosis of ALS  
Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative...
US20130149712 FOLLISTATIN-LIKE PROTEIN-1 AS A BIOMARKER FOR INFLAMMATORY DISORDERS  
The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated...
US20130149290 Engineered Dendritic Cells and Uses for the Treatment of Cancer  
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12...
US20130146821 REDOX STIMULATED VARIABLE-MODULUS MATERIAL  
A material having a first non-zero elastic modulus capable of reversibly changing the first non-zero elastic modulus to a second non-zero elastic modulus in response to a redox reaction occurring...
8461993 Wireless systems having multiple electronic devices and employing simplified fabrication and matching, and associated methods  
A means and method to connect multiple IC chips to a single apparatus where the IC chips may function as a passive system or network in space. The collection of antennae and coupled near field...
8460637 Reconstitutable microsphere compositions useful as ultrasonic contrast agents  
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...
8460269 Directed cell-based therapy using microbubble tagged cells  
The disclosed technology describes compositions and methods useful for providing cell based therapy. For example, one embodiment of cell based therapy involves the regeneration of injured tissue...
US20130131278 MODIFICATION OF SURFACES WITH POLYMERS  
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
US20130129663 REVERSE THERMAL GELS AND USES THEREFOR  
Biodegradable triblock copolymer compositions are provided which are useful in tissue engineering and drug delivery. The copolymers are reverse thermal gels in that when heated from a lower...
8445261 Apparatus for holding cells  
An apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired...
US20130118904 SEPARATION OF PARTICLES USING MULTIPLEXED DIELECTROPHORESIS  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. Time-multiplexed dielectrophoresis can be employed by cycling between two...
8442630 Automated assessment of atrioventricular and ventriculoatrial conduction  
A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An...
8440993 Ultrahigh density patterning of conducting media  
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
8440992 Ultrahigh density patterning of conducting media  
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
US20130116575 IMPLANTABLE DOPPLER BLOOD FLOW MONITOR AND DOPPLER PROBE  
A Doppler blood flow monitoring system comprises a sensor cuff capable of being secured around an exterior surface of a patient's vessel, at least one transducer attached to the sensor cuff for...
8435948 Methods for inhibiting osteoclastic bone resorption and bone loss comprising administration of an anti-FSH or anti-FSHR antibody  
The invention discloses compositions and methods for decreasing osteoclast which are useful for the treatment of a variety of bone loss disorders.
US20130102662 USE OF INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS AND NITRIC OXIDE SCAVENGERS TO INHIBIT POST-TRAUMATIC IMMUNODEPRESSION  
The present invention relates to methods and compositions that inhibit the effects of nitric oxide for inhibiting post-traumatic immunodepression. It is based, at least in part, on the discovery...
US20130102626 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20130101676 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
8426146 Multiparameteric method for assessing immune system status  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
8425583 Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20130096186 IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR RETARGETING TO NOVEL NON-HSV RECEPTORS  
The invention provides modified HSV vectors that exhibit enhanced entry of cells, either through direct infection and/or lateral spread. In one aspect, HSV vectors of the present invention can...
US20130095566 Flux Balance Analysis With Molecular Crowding  
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
US20130095516 Light Refraction Imaging to Measure Liquid Volume  
A method to measure the volume of fluid present that relies on the pattern of light refraction as it passes though an airway surface liquid (ASL) meniscus. The method comprises allowing epithelial...
8421274 Wireless energy transfer system  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load....
US20130090516 Local Anesthesia By Magnet-Directed Concentration of Nanoparticle Conjugated Anesthetic  
Methods and formulations for induction of local anesthetic effects employing magnetic nanoparticles conjugated to anesthetic molecules. Magnetic nanoparticle-local anesthetic conjugates may be...
US20130085511 Novel Tactile Feedback System for Robotic Surgery  
Apparatuses and methods for the haptic sensation of forces at a remote location. Groups of MEMS-based pressure sensors are combined into sensor arrays. In some embodiments, the pressure sensors are...
US20130081786 VARIABLE THERMAL INSULATION  
A device for selectively controlling the passage of thermal energy therethrough by selectively varying the overall thermal conductivity of the device comprises a structure having at least one...
US20130079241 Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse  
The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid...
US20130077046 NORMALIZATION OF RETINAL NERVE FIBER LAYER THICKNESS MEASUREMENTS MADE BY TIME DOMAIN-OPTICAL COHERENCE TOMOGRAPHY  
A scan location matching (SLM) method identifies conventional time domain optical coherence tomography (TD-OCT) circle scan locations within three-dimensional spectral domain OCT scan volumes. A...
8404213 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
US20130072790 SELECTION AND OPTIMIZATION FOR CARDIAC RESYNCHRONIZATION THERAPY  
Systems and methods for imaging and analyzing a patient heart are described. Imaging can be performed with a variety or combination of methods, including single photon emission computed tomography,...
US20130072547 USE OF TOLL-LIKE RECEPTOR-9 AGONISTS, TOLL-LIKE RECEPTOR-4 ANTAGONISTS, AND/OR NUCLEAR OLIGOMERIZATION DOMAIN-2 AGONISTS FOR THE TREATMENT OF PREVENTION OF TOLL-LIKE RECEPTOR-4-ASSOCIATED DISORDERS  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis...
US20130071930 POLYESTERS, METHODS OF MAKING POLYESTERS AND USES THEREFOR  
Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue...
US20130071419 UNIVERSAL DENGUE VIRUS SEQUENCES AND METHODS OF USE  
Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments (such...
8398576 Removal of contrast agents from blood  
The invention provides a system and a method for removal of contrast from blood. In one aspect, the invention provides a catheter for removal of contrast from the veins that drain the cerebral...
US20130059912 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its m...