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Patents and Patent Applications from University of Pittsburgh


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US20130323700 HYBRID PHYSICAL-VIRTUAL REALITY SIMULATION FOR CLINICAL TRAINING CAPABLE OF PROVIDING FEEDBACK TO A PHYSICAL ANATOMIC MODEL  
Systems and methods facilitating training in clinical procedures via mixed reality simulations are disclosed. Such a system can comprise a physical model and a virtual model of an anatomic region...
US20130323224 USE OF MYCOBACTERIUM SMEGMATIS TREHALOSE DIMYCOLATE HYDROLASE  
Methods are disclosed herein for treating an infection with a Mycobacterium infection. Methods are also disclosed for treating a Mycobacterium biofilm. The method include the use of trehalose...
US20130321064 HIERARCHICAL SINGLE MOLECULE SWITCH BASED ON STIMULATED INTERNAL CLUSTER MOTION WITHIN A HOLLOW MOLECULAR CAGE  
Systems and methods related to single molecule switching devices are disclosed. One example method can include the step of applying a tunneling current across a tunneling junction. The tunneling...
US20130317376 Electrocardiogram Reconstruction from Implanted Device Electrograms  
A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an...
US20130316959 USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
US20130316349 N-METHYLPURINE DNA GLYCOSYLASE AND POLYMERASE BETA AS BIOMARKERS FOR ALKYLATOR CHEMOTHERAPY POTENTIATION  
Described herein is the finding that polymerase β (Polβ) and N-methylpurine DNA glycosylase (MPG) can be used as biomarkers to evaluate the sensitivity of a subject to combination therapy that i...
US20130315857 Kexin-Derived Vaccines to Prevent or Treat Fungal Infections  
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat...
US20130309664 HEAT SHOCK PROTEINS AS AUTOANTIGENS  
The present invention relates to methods of diagnosing and/or determining a prognosis for various diseases, including lung diseases such as idiopathic pulmonary fibrosis, chronic obstructive lung...
US20130299773 LOW VOLTAGE NANOSCALE VACUUM ELECTRONIC DEVICES  
An electronic device including a first conducting layer, a second conducting layer, and an insulating layer provided between the conducting layers. At least one side wall extends from the first...
US20130299427 Urinary Biomarkers For Predicting Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
8580561 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
8580229 Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
US20130295046 INTERLEUKIN-13 RECEPTOR ALPHA 2 PEPTIDE-BASED BRAIN CANCER VACCINES  
Provided herein are interleukin-13 receptor α2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need ...
US20130293025 RESONANCE-BASED WIRELESS POWER TRANSFER SYSTEM  
A wireless power transfer system including a driver coil array, a hexagonally-packed transmitter mat, a receiver coil, and a load coil for powering a medical implant. The magnetically coupled...
8574851 Prediction and prevention of preeclampsia  
The present disclosure relates to methods for detecting an increased risk of preeclampsia, determining the presence of preeclampsia, reducing the likelihood that preeclampsia will develop and...
8574584 EphA2 T cell epitopes and uses therefor  
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative...
US20130289261 THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGEN  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
US20130287765 FSH AND FSH RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR INHIBITING OSTEOCLASTIC BONE RESORPTION AND BONE LOSS IN OSTEOPOROSIS  
The invention discloses compositions and methods for decreasing osteoclast which are useful for the treatment of a variety of bone loss disorders.
8569052 Oxygen depletion devices and methods for removing oxygen from red blood cells  
An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed...
8568996 MMP activation peptide detection in biological samples  
A method is provided along with related reagent kits for aiding the diagnosis of IPF or other interstitial lung diseases, as well as for potential monitoring of disease progression or therapeutic...
US20130281395 NOVEL TLR4 INHIBITORS FOR THE TREATMENT OF HUMAN INFECTIOUS AND INFLAMMATORY DISORDERS  
The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In...
US20130281382 STABLE LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
US20130280733 Biomarkers for the Diagnosis of ALS  
Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative...
US20130278257 MRI PULSE SEQUENCE BASED ON Q-SPACE TRAJECTORY TECHNIQUE  
Systems and methods capable of improving acquisition times associated with obtaining diffusion-weighted magnetic resonance imaging data are discussed. In aspects, multiple points in q-space can be...
8562868 Ternary metal transition metal non-oxide nano-particles, methods and applications thereof  
The present invention is related to ternary metal transition metal non-oxide nano-particle compositions, methods for preparing the nano-particles, and applications relating in particular to the use...
US20130274314 MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF  
Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped,...
8557235 Bone substitute compositions, methods of preparation and clinical applications  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
US20130267794 Method, Apparatus and System for Food Intake and Physical Activity Assessment  
Electronic systems, devices and methods are provided to accurately record and analyze food intake and physical activity in a subject. A device is provided to be placed on a subject which records...
US20130260701 Method of Controlling RF Transmissions to Mitigate Interference with Critical Care Medical Equipment  
Various methods of mitigating RF interference with one or more critical care medical devices is provided, wherein a predetermined threshold energy acceleration value is associated with the one or...
US20130259873 METHODS FOR TREATING A TUMOR USING AN ANTIBODY THAT SPECIFICALLY BINDS HMW-MAA  
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer...
US20130259865 FULLY HUMAN ANTIBODIES TO HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN AND USES THEREOF  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
US20130253663 BIOHYBRID COMPOSITE SCAFFOLD  
A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods...
US20130253299 MONITORING AND REGULATING PHYSIOLOGICAL STATES AND FUNCTIONS VIA SENSORY NEURAL INPUTS TO THE SPINAL CORD  
Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root...
US20130251668 USE OF OSTEOPROTEGERIN (OPG) TO INCREASE HUMAN PANCREATIC BETA CELL SURVIVAL AND PROLIFERATION  
It is disclosed herein that osteoprotegerin increases human beta cell proliferation and survival. Methods are provided for increasing beta cell proliferation, but contacting a beta cell with an...
US20130247973 NANO-OPTIC REFRACTIVE OPTICS  
A vertical dipole array structure includes a substrate that supports a film, which is not comprised of a negative-index metamaterial. The film includes a plurality of tilt-oriented portions and...
8541415 Targeting an HIV-1 nef-host cell kinase complex  
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory...
8540209 Active combustion flow modulation valve  
A flow modulation valve has a slidably translating hollow armature with at least one energizable coil wound around and fixably attached to the hollow armature. The energizable coil or coils are...
US20130246084 VERSATILE AND INTEGRATED SYSTEM FOR TELEHEALTH  
A versatile and integrated system for telehealth and/or telerehabilitation which is an architecture or platform for developing various telerehabilitation applications is provided. The system can be...
8535719 Biohybrid elastomeric scaffolds and methods of use thereof  
Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms,...
US20130238063 METHODS, DEVICES AND SYSTEMS FOR TREATING INSOMNIA BY INDUCING FRONTAL CEREBRAL HYPOTHERMIA  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20130237685 LINEAR ASSEMBLIES, BRANCHED ASSEMBLIES, MACROCYCLES AND COVALENT BUNDLES OF FUNCTIONALIZED BIS-PEPTIDES  
Provided is a macromolecule comprising two or more functionalized bis-peptides connected by one or more linkers, and methods of making thereof. In some embodiments, the functionalized bis-peptides...
US20130236394 THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER`S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
8530375 Regenerable solid imine sorbents  
Two new classes of amine-based sorbents are disclosed. The first class comprises new polymer-immobilized tertiary amine sorbents; the second class new polymer-bound amine sorbents. Both classes are...
8530227 Degradation of nanomaterials  
A method of degrading carbon nanomaterials includes mixing the carbon nanomaterials with a composition comprising a peroxide substrate and at least one catalyst selected from the group of an enzyme...
US20130229663 SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY  
Due to potential sampling errors (due to small tissue samples not necessarily directly from the developing tumor) and limited optical resolution (˜1 micron), cancer may be missed or detected too ...
8524248 Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma  
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a...
US20130224761 NON COVALENT MOLECULAR STRUCTURE, COMPRISING A PORPHYRIN BASED GLYCOCONJUGATE, DEVICE COMPRISING THE SAME AND ITS USE FOR DETECTION OF LECTIN  
The present invention relates to a non covalent molecular structure comprising a carbon nanostructure and a porphyrin based glycoconjugate (I) which is linked to the said carbon nanostructure by a...
US20130222802 MANIPULATION, DETECTION, AND ASSAY OF SMALL SCALE BIOLOGICAL PARTICLES  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. A particle manipulation device contains a plurality of electrodes formed on...
8518905 Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment of prevention of toll-like receptor-4-associated disorders  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis...
8518903 Use of toll-like receptor-9 agonists  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis...