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Patents and Patent Applications from University of Pittsburgh


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US20100215623 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
7781164 Method for diagnosing renal diseases or predispositions  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
7776908 Wortmannin analogs and methods of using same  
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well, as tumor formation in a subject are described herein.
US20100191174 HAND-HELD ELECTRICAL STIMULATION DEVICE  
Apparatuses and methods for the safe and efficient electrical stimulation of tissue. The apparatuses of the present invention are preferably hand-held and are capable of providing electrical...
US20100190239 DEGRADATION OF NANOMATERIALS  
A method of degrading carbon nanomaterials includes mixing the carbon nanomaterials with a composition comprising a peroxide substrate and at least one catalyst selected from the group of an enzyme...
7763097 Devices, systems and methods for reducing the concentration of a chemical entity in fluids  
A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized...
US20100184953 STABLE LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
US20100173971 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
7750632 Method for producing a magnetic resonance image of an object having a short T2 relaxation time  
A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded magnetic...
7749959 Use of HMGB fragments as anti-inflammatory agents  
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
7747274 Method and system for securely communicating information using multiple RF carriers  
Amplitude modulation of multiple carriers provides a pulse width modulated train resulting in a novel and effective communication mechanism to overcome difficulties in certain RF applications,...
US20100158875 MUSCLE DERIVED CELLS FOR THE TREATMENT OF GASTRO-ESOPHAGEAL PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20100158815 Biological Cell Tracking With Ultrasound  
This invention addresses the clinical problem of how to optimize biological cell based therapies, such as stem cell therapy. Currently, cell therapies administered by intravenous, intra-arterial,...
7736104 Docking and securement system for wheeled mobility devices  
A docking device for use with a wheeled mobility device having a device interface on a rear thereof includes a securing mechanism to dock with the device interface. The securing mechanism is...
US20100145147 MAGNETIC DEVICE FOR GUIDING CATHETER AND METHOD OF USE THEREFOR  
One or more external magnets that are suitable for placement on the back or front of a patient's neck and methods for using the external magnet(s) to guide a feeding tube containing one or more...
7734077 Method of assessing localized shape and temperature of the human body  
A method of objectively quantifying assessments of joints having arthritis for purposes of assessment, diagnosis and treatment. The objective measurements utilize known imaging modalities including...
7732180 Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region  
The present invention provides porcine Forssman synthetase (FSM synthase) (Globoside α-N-acetylgalactosaminyltransferase) protein, cDNA, and genomic DNA sequence. Furthermore, the present ...
US20100137541 End-to-end joining of nanotubes  
A method for joining nanotubes end-to-end, includes contacting the nanotubes with a joining fluid. The joining fluid has at least one property that is different from at least one property...
7722920 Method of making an electronic device using an electrically conductive polymer, and associated products  
Described are methods of making an electronic device, such as an RFID tag, including fabricating an antenna by depositing an electrically conductive polymer onto a substrate. The electrically...
7718603 Selective targeting agents for mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20100121273 Emergency preservation and resuscitation methods  
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods...
7711174 Methods and systems for imaging cells  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
7704507 Anticancer vaccine and diagnostic methods and reagents  
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the...
7704503 Use of IL-17F in diagnosis and therapy of airway inflammation  
The invention is related to findings that IL-17F-mediated inflammation of airway passages may be mediated via signaling through IL-17R on the basolateral surface of human respiratory epithelial...
US20100100510 DYNAMIC DISCRETE DECISION SIMULATION SYSTEM  
A system that enables dynamic discrete decision simulation is provided. Simulation has many advantages in modeling complex systems to facilitate decision making. The innovation discloses a system...
7702140 Method of assessing a body part  
A method of assessing a body part includes obtaining two or more types of data through a combination of two or more of the following four imaging modalities: (1) obtaining surface topography data...
7700794 Fluorous tagging compounds and methods of increasing the fluorous nature of compounds  
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group, Rs is a...
7695909 Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26  
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of...
7691416 Methods of treating vascular disease  
The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical...
US20100081192 EARLY PROSTATE CANCER ANTIGENS (EPCA), POLYNUCLEOTIDE SEQUENCES ENCODING THEM, AND THEIR USE  
A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without...
US20100081148 Urinary Biomarkers To Predict Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
US20100078599 Nanoscale Silicon-Based Compositions and Methods of Preparation  
The present invention is related to nano-particle compositions, methods of their preparation and applications thereof. The nano-particle compositions include silicon-containing nano-particles, a...
7687079 Methods of treating ileus  
The present invention relates to a method of treating ileus in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
US20100073188 System and Method for Real Time Asset Location and Tracking  
A system for estimating the current position of an asset within a location that includes a transponder associated with the asset, a plurality of wireless interface devices provided within the...
US20100072424 LANTHANIDE METAL-ORGANIC FRAMEWORKS AND USES THEREOF  
Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new...
7678057 Device and system that identifies cardiovascular insufficiency  
In an embodiment, the present invention provides a device that identifies cardiovascular dysfunction of a subject. The claimed device comprises a controller, a transducer, and a processor. The...
7672732 Portable apparatus that delivers power and information to implantable devices  
An apparatus for powering an implant includes first energy interface elements, a removeably attachable holding device and a first energy source, such as a battery. An energy conversion circuit...
US20100048682 INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS  
The invention provides anticancer methods. In one embodiment, the inventive method involves the co-administration to cancerous cells of (a) a chemotherapeutic agent, radiation, or a combination of...
US20100047841 SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF  
Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as...
7662793 Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from a Pol III promoter  
A nucleic acid is provided comprising an expression cassette which includes transcription control sequences of a member of a class of Pol III-transcribed genes in which no transcribed portion of...
7662566 Gene copy number profiling  
The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a...
7662561 Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma  
Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided....
US20100035869 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20100030101 Method And System For Acquiring Loudness Level Information  
The present invention relates to methods for acquiring hearing threshold values in a subject comprising providing a sound to the subject; providing a monitor for monitoring a movement response by...
7655640 Camptothecin analogs and methods of preparation thereof  
A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable...
7655468 Stable lipid-comprising drug delivery complexes and methods for their production  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
7655461 Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
7655216 Vaccine for activating helper function of CD8+ Tcells  
The invention provides compositions and methods for treating or preventing a target disease in a mammal by induction of memory T cells. The methods comprise (1) administering a sensitizing...
US20100022520 MALONYL-COA ACETYLTRANSFERASE INHIBITORS AGAINST ANTIBIOTIC RESISTANT BACTERTIA  
Compounds characterized by thiolactone or thiomorpholino cores display useful antibiotic and radioprotective properties. The latter properties are believed to arise from an ability of the compounds...
US20100021388 BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...