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Patents and Patent Applications from University of Pittsburgh


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7662561 Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma  
Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided....
US20100035869 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20100030101 Method And System For Acquiring Loudness Level Information  
The present invention relates to methods for acquiring hearing threshold values in a subject comprising providing a sound to the subject; providing a monitor for monitoring a movement response by...
7655640 Camptothecin analogs and methods of preparation thereof  
A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable...
7655468 Stable lipid-comprising drug delivery complexes and methods for their production  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
7655461 Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
7655216 Vaccine for activating helper function of CD8+ Tcells  
The invention provides compositions and methods for treating or preventing a target disease in a mammal by induction of memory T cells. The methods comprise (1) administering a sensitizing...
US20100022520 MALONYL-COA ACETYLTRANSFERASE INHIBITORS AGAINST ANTIBIOTIC RESISTANT BACTERTIA  
Compounds characterized by thiolactone or thiomorpholino cores display useful antibiotic and radioprotective properties. The latter properties are believed to arise from an ability of the compounds...
US20100021388 BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
US20100019207 Ternary Metal Transition Metal Non-Oxide Nano-Particles, Methods and Applications Thereof  
The present invention is related to ternary metal transition metal non-oxide nano-particle compositions, methods for preparing the nano-particles, and applications relating in particular to the use...
US20100018920 REACTION AND SEPARATION METHODS  
A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second...
US20100008940 PEPTIDE ANALOGS CAPABLE OF ENHANCING STIMULATION OF A GLIOMA-SPECIFIC CTL RESPONSE  
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for ...
US20100002929 Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation  
The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell...
US20090326070 VINYL SUBSTITUTED FATTY ACIDS  
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty...
US20090325214 NUCLEAR MATRIX PROTEIN ALTERATIONS ASSOCIATED WITH COLON CANCER AND THEIR USE AS MARKERS FOR COLORECTAL CANCER  
CCSA-2 levels in serum samples from individuals suffering from colorectal cancer can be used gauging the progression of a colorectal cancer condition. In particular, the progression of a colorectal...
US20090318309 Thermo-reversibly gelled colloidal suspensions and a process for making the same  
Disclosed is a thermoreversible synthesis of a new type of material made by embedding a colloidal population within a thermo-reversibly gelled polymer. The polymer may be a physically cross-linked...
US20090310393 Motion Activated Amplifier  
An electronic device that includes a motion activated amplifier structured to receive a first DC signal having a first DC voltage level and output a second DC signal having a second DC voltage...
US20090309344 RESTRAINT SYSTEMS FOR USE IN VEHICLES AND METHODS OF RESTRAINT  
A safety restraint system to restrain a wheelchair-seated person in a vehicle includes a belt including a pelvic restraining portion connectable between a first side and an second side. The system...
US20090306027 GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF THE GENETIC VARIATION OF G-PROTEIN BETA 3 SUBUNIT POLYMORPHISM  
The invention provides methods for treating various indications and diseases in a patient in need thereof, wherein the patient has a C825T polymorphism in the G protein beta3 subunit (GNB3),...
7629315 Compositions for blocking the inhibitory effect of human CRP on human leptin  
Leptin controls the production of C-Reactive Protein (CRP), which, in turn, interacts with leptin to diminish its ability to signal satiety and reduce food intake. The interactions between leptin...
7628888 Cellulosic composition  
A composition includes at least one hydrophilic polymer containing primary (—NH2) and/or secondary (—NHR) amine groups and at least one saccharide containing a reducible function. A method of inc...
US20090299948 IDENTIFICATION AND MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS  
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
US20090298198 DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS  
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
US20090298193 ATOMIC EMISSION SPECTROSCOPY ON A CHIP  
A method of inducing explosive atomization of materials is provided using a metal-oxide-semiconductor (MOS)-based structure under electrical excitation. Explosive atomization of the gate electrode...
US20090297567 Method For Ultrasound Triggered Drug Delivery Using Hollow Microbubbles With Controlled Fragility  
A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The...
US20090291145 MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES  
A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are targeted to bind to primary transcripts...
US20090277805 ELECTROCHEMICAL SENSORS, SENSOR SYSTEMS AND METHOD OF SENSING ANALYTES  
A sensor, includes a working electrode including a first layer formed of a polymeric material. The first layer includes a first surface across which an analyte in a sample can be transported and a...
US20090274628 RECONSTITUTABLE MICROSPHERE COMPOSITIONS USEFUL AS ULTRASONIC CONTRAST AGENTS  
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...
7612162 Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response  
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for ...
US20090268159 AUTOMATED ASSESSMENT OF OPTIC NERVE HEAD WITH SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY  
A fully automated optic nerve head assessment system, based on spectral domain optical coherence tomography, provides essential disc parameters for clinical analysis, early detection, and...
US20090263335 USE OF AEROSOLIZED CYCLOSPORINE FOR PREVENTION AND TREATMENT OF PULMONARY DISEASE  
The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the...
US20090253662 GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF GENETIC VARIATION OF ALDOSTERONE SYNTHASE PROMOTER POLYMORPHISM  
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the...
7598042 Early prostate cancer antigens (EPCA), polynucleotide sequences encoding them, and their use  
A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without...
7597695 Posterior oblique lumbar arthrodesis  
Instruments and methods for spinal stabilization are disclosed. In preferred embodiments, the invention provides greater stabilization of vertebral bodies through methods including combinations of...
US20090246164 TISSUE ADHESION  
A method of adhering biological tissue that includes applying a bio-degradable adhesive to the tissue. The adhesive includes a moisture-curable, isocyanate-functional component prepared by reacting...
US20090239947 Inhibition of proliferation and fibrotic response of activated corneal stromal cells  
Provided herein are methods of preventing a fibrotic response and/or scarring in a wound, comprising administering to a subject a composition comprising an amount of an amide or ester of an...
US20090238807 CELL LINE  
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
US20090238792 SUPPRESSION OF POSTOPERATIVE ILEUS  
The invention provides a method for suppressing postoperative ileus in connection with the performance of a surgical procedure on a patient. In accordance with the inventive method, interleukin-10...
7588905 Identification and monitoring of systemic lupus erythematosus  
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
US20090226935 NUCLEAR MATRIX PROTEIN ALTERATIONS ASSOCIATED WITH COLON CANCER AND COLON METASTASIS TO THE LIVER, AND USES THEREOF  
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and...
7585640 Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells  
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
US20090214092 METHOD OF ASSESSING A BODY PART  
A method of assessing a body part includes obtaining two or more types of data through a combination of two or more of the following four imaging modalities: (1) obtaining surface topography data...
US20090208513 Diagnostic And Therapeutic Uses Of Augmenter Of Liver Regeneration In Inflammatory Conditions  
The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver...
US20090207000 Multiple Antenna Energy Harvesting  
Energy harvesting circuits and associated methods are provided that employ multiple antennas to optimize the amount of energy that is harvested while at the same time making efficient use of tag...
7572596 Modulation of the neuroendoctrine system as a therapy for motor neuron disease  
The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a...
US20090192128 GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF GENETIC VARIATION OF BETA 1 ADRENERGIC RECEPTOR GLY389ARG POLYMORPHISM  
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the...
7567824 Recharging method and apparatus  
The present invention provides apparatus and an associated method for remotely energizing power storage devices. Energization may preferably be effected through the use of RF energy from a base...
US20090187097 Electrocardiogram Reconstruction From Implanted Device Electrograms  
A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an...
7560538 Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region  
The present invention provides porcine isogloboside 3 (iGb3) synthase protein, cDNA, and genomic DNA regulatory sequence. The present also invention includes porcine animals, tissue and organs as...
7559895 Combining tomographic images in situ with direct vision using a holographic optical element  
A device for combining tomographic images with human vision using a half-silvered mirror to merge the visual outer surface of an object (or a robotic mock effector) with a simultaneous reflection...