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Patents and Patent Applications from University of Pittsburgh


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7544415 Polymer and method for using the polymer for solubilizing nanotubes  
A new, non-wrapping approach to solubilize nanotubes, such as carbon nanotubes, in organic and inorganic solvents is provided. In accordance with certain embodiments, carbon nanotube surfaces are...
US20090143832 Automated Assessment Of Atrioventricular And Ventriculoatrial Conduction  
A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An...
US20090142269 ISOTOYPICALLY-LABELED BENZOTHIAZOLE COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS  
The present invention provides an isolated linezolid impurity, desfluoro linezolid, the preparation thereof and its use as a reference standard.
US20090136553 TRIGGERABLY DISSOLVABLE HOLLOW FIBERS FOR CONTROLLED DELIVERY  
Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded...
7538220 Intermediates in the preparation of homocamptothecin analogs  
A compound having the formula in racemic form, enantiomerically enriched form or enantiomerically pure form; wherein X is a radical precursor; R5 is a C1-10 alkyl group, an alkenyl group, an...
US20090131511 PALMARUMYCIN BASED INHIBITORS OF THIOREDOXIN AND METHODS OF USING SAME  
Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in...
US20090129721 FIBER OPTIC GAS SENSOR  
A gas sensor includes an in-fiber resonant wavelength device provided in a fiber core at a first location. The fiber propagates a sensing light and a power light. A layer of a material is attached...
US20090123441 Engineered Dendritic Cells and Uses for the Treatment of Cancer  
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12...
7531634 Bladder matrix protein peptides and methods of detection of bladder cancer  
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell...
7531167 Herpes simplex virus vector  
The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
US20090118611 COILS FOR MAGNETIC RESONANCE SPECTROSCOPY AND IMAGING OF HUMAN BREAST  
System(s) and method(s) for magnetic resonance imaging and spectroscopy, and magnetic resonance spectroscopic imaging (MRSI) are provided. A unified heteronuclear coil system includes a volume coil...
7528698 Multiple antenna energy harvesting  
Energy harvesting circuits and associated methods are provided that employ multiple antennas to optimize the amount of energy that is harvested while at the same time making efficient use of tag...
7528696 Determining the three-dimensional read accuracy of an RFID tag using a power scaling factor  
A method of generating a normalized matrix for use in determining one or more read accuracies of an RFID tag at selected points in space relative to a transmitter associated with the RFID tag. The...
7528174 Selective targeting agents for mitochondria  
Compositions and methods are disclosed for treating an illness that is caused or associated with cellular damage or dysfunction which is caused by excessive mitochondrial production of reaction...
7527634 Device and method of use for functional isolation of animal or human tissues  
A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the...
7525436 Methods and apparatus for reducing power consumption of an active transponder  
A power management method for a transponder having a plurality of circuits including at least a first circuit having a first active state requiring at least a first power level, and a second...
7524653 Small interfering RNA libraries and methods of synthesis and use  
In one aspect, the invention provides a random or semirandom siRNA (encoding) library. Another aspect of the invention pertains to methods for construction of random or semirandom siRNA (encoding)...
US20090105782 VAGUS NERVE STIMULATION APPARATUS, AND ASSOCIATED METHODS  
Methods and apparatus for providing vagus nerve stimulation for the treatment of diseases such as depression and epilepsy that do not require an onboard, implanted power supply. Power may be...
US20090104639 BIOMARKERS FOR MOTOR NEURON DISEASE  
The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the...
US20090100969 TEMPLATES FOR CONTROLLING SYNTHESIS OF NANOPARTICLES INTO DISCRETE ASSEMBLIES  
An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.
7521504 Irreversible immobilization of enzymes into polyurethane coatings  
A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of...
US20090099533 VIRUS DERIVED ANTIMICROBIAL PEPTIDES  
Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1)...
US20090098915 RECHARGING METHOD AND APPARATUS  
The present invention provides apparatus and an associated method for remotely energizing power storage devices. Energization may preferably be effected through the use of RF energy from a base...
US20090098094 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
7514418 Camptothecin analogs and methods of preparation thereof  
The present invention provides generally a compound having the following general formula (1): wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl...
US20090087441 Wortmannin Analogs and Methods of Using Same in Combination with Chemotherapeutic Agents  
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the...
US20090087376 Heterocyclic Dye Compounds For In Vivo Imaging And Diagnosis Of Alzheimer's Disease  
The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid...
US20090081172 THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGEN  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
US20090081130 MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS AND FOR DELIVERY OF DRUGS INTO THE BLOODSTREAM  
Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas,...
US20090081119 INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS  
The invention provides anticancer methods. In one embodiment, the inventive method involves the co-administration to cancerous cells of (a) a chemotherapeutic agent, radiation, or a combination of...
US20090080598 BI-PLANE X-RAY IMAGING SYSTEM  
A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of...
US20090075956 Genetic Risk Assessment in Heart Failure: Impact of the Genetic Variation of NOS3  
The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the...
US20090075902 INHIBITING THE SIGNS OF AGING BY INHIBITING NF-KAPPA B ACTIVATION  
The present invention relates to methods and compositions for reducing and/or delaying one or more signs of aging which comprise inhibiting NF-kappa B activation. It is based, at least in part, on...
US20090074709 METHODS, DEVICES AND SYSTEMS FOR BIOCIDAL SURFACE ACTIVITY  
A method of applying a biocidal polymer to a surface including applying a solution of the biocidal polymer to the surface, wherein the biocidal polymer includes biocidal groups and the biocidal...
US20090073434 SURFACE PLASMON-ENHANCED NANO-OPTIC DEVICES AND METHODS OF MAKING SAME  
A nanostructured optical device includes a metal film or a plurality of metal islands having an array of a plurality of openings having a width that is less than at least one first predetermined...
US20090070729 METHOD AND SOFTWARE TOOL FOR DESIGNING AN INTEGRATED CIRCUIT  
A method of designing an integrated circuit for use in an application having standards having a plurality of primitives, wherein each of the primitives has a corresponding response. The method...
US20090069856 DEVICES, SYSTEMS AND METHODS FOR CHARACTERIZATION OF VENTRICULAR FIBRILLATION AND FOR TREATMENT OF VENTRICULAR FIBRILLATION  
A defibrillation system for use in treatment of ventricular fibrillation includes at least one sensor to measure heart rhythm; at least one applicator to apply a defibrillation pulse to a patient;...
US20090068211 IMMUNOGENICALLY-ENHANCED POLYPEPTIDES AND RELATED METHODS  
Described herein are immunogenically-enhanced polypeptides, such as KSHV LANA1 polypeptides, related methods of eliciting an immune response to the polypeptides and related nucleotide sequences....
US20090066963 ULTRAFAST MICROSCOPY OF SURFACE ELECTROMAGNETIC FIELDS  
System(s) and method(s) to probe electromagnetic fields at the surface of a solid-state material are provided. The technique combines ultrafast (e.g., less than 10 fs) optical excitation and...
US20090062130 NUCLEOSOME-BASED BIOSENSOR  
A nucleosome-based biosensor can detect events of transcriptional activity. The biosensor includes a nucleosome-forming DNA that contains at least one nuclear responsive DNA sequence; a core...
US20090061451 BIOSENSORS AND RELATED METHODS  
Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor...
US20090061445 FLUX BALANCE ANALYSIS WITH MOLECULAR CROWDING  
Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium;...
7497456 Wheelchair pushrim  
A pushrim with increased surface area and an insert between the wheel and the pushrim. In the preferred embodiment, the cross-section of the pushrim is an elongated circle and the insert is a...
US20090054958 Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders  
A method and device for treating neurological disorders involving the application of noninvasive, regional brain thermal stimulation to a region of a patient's head associated with a subject...
US20090053149 SURFACTANT-BASED ANTIMICROBIAL SOLUTION FOR INHALATION  
A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via...
7494566 Composition for increasing cellulosic product strength and method of increasing cellulosic product strength  
A composition includes water; at least one hydrophilic polymer containing at least two groups which are independently the same or different a primary amine group or a secondary amine group and at...
US20090049415 METHOD AND SOFTWARE TOOL FOR AUTOMATIC GENERATION OF SOFTWARE FOR INTEGRATED CIRCUIT  
A method of generating software code for a processor of an IC based on a simple input description of the IC's standards. The method includes generating a macros description of each of the...
7492530 Metallic nano-optic lenses and beam shaping devices  
A nano-optic device comprises a plurality of subwavelength apertures in a metal film or between metal islands. The device is adapted to shape a radiation beam transmitted there through. For...
US20090042808 USE OF MITOCHONDRIA-TARGETED ELECTRON SCAVENGERS AS ANTI-INFLAMMATORY AGENTS  
Provided herein are methods for using mitochondria-targeted electron scavengers as anti-inflammatory agents. The mitochondria-targeted electron scavenger comprises a free radical-scavenging group...
US20090036945 METHODS AND SYSTEMS FOR ACHIEVING A PHYSIOLOGICAL RESPONSE BY PUDENDAL NERVE STIMULATION AND BLOCKADE  
Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The...