Patents and Patent Applications from University of Pittsburgh


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US20120244136 Cardiac-Specific Protein Targeting Domain  
The present invention relates to Cardiac Targeting Peptides or CTPs that are able to transduce cardiomyocytes specifically in culture and in vivo, and to methods for using such peptides and their...
US20120237954 BIOMARKERS FOR PROGNOSES OF PULMONARY DISEASES  
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic...
US20120237485 Trabecular Meshwork Stem Cells  
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and...
US20120235997 IMAGE GENERATING APPARATUS, METHOD OF GENERATING IMAGE, PROGRAM, AND RECORDING MEDIUM  
The present application generates an image in which a contour line is drawn about a tuned object A in a virtual three-dimensional space when a part of the tuned object A is overlapped by another...
US20120228137 pH SENSOR  
A pH sensor includes an enclosed fluidic channel, an electrolyte solution within the fluidic channel, a first electrode exterior to the fluidic channel, a second electrode within the fluidic...
8264458 Variable compliance joystick with compensation algorithms  
The present invention provides variable compliance joysticks with mechanical and software customization, and with an integrated control capability, and a method of systematically determining the...
8263329 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20120226031 PALMARUMYCIN BASED INHIBITORS OF THIOREDOXIN AND METHODS OF USING SAME  
Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in...
8258957 Methods and apparatus for switching a transponder to an active state, and asset management systems employing same  
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
US20120220645 GENETIC CHANGES IN ATM AND ATR/CHEK1 AS PROGNOSTIC INDICATORS IN CANCER  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20120220536 USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS  
C-terminal endostatin polypeptides are disclosed herein. In some embodiments, these polypeptides include or consist of (1) at least at least 40 consecutive amino acids of the amino acid sequence...
8253779 System for remote guidance by expert for imaging device  
Systems and methods for combining tomographic images with human vision. The systems preferably include a first assembly located proximal to an object to be imaged and a second assembly remote from...
US20120213423 BLOOD VESSEL SEGMENTATION WITH THREE DIMENSIONAL SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY  
In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to...
US20120208712 SIRTUIN 5 POLYMORPHISMS AND NEUROLOGICAL DISEASES  
A method for determining a subject's risk of developing a neurological disease or disorder such as Huntington's or Parkinson's disease, based on the presence of SIRT5prom2 (rs9382222) C/C genotype...
US20120207687 TOPICAL FORMULATIONS OF TARGETED NITROXIDE AGENTS  
A method for preventing or treating skin damage in a radiotherapy subject, comprising topically administering to the subject a composition that includes a therapeutically effective amount at least...
8241892 Method and apparatus for holding cells  
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown,...
US20120201799 DEVICES, SYSTEMS AND METHODS FOR CELL MODIFICATION  
A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to...
8236282 Benzothiazole derivative compounds, compositions and uses  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
8236038 Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders  
A method and device for treating neurological disorders involving the application of noninvasive, regional brain thermal stimulation to a region of a patient's head associated with a subject...
US20120189545 ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS  
Benzofuran compounds which contain at least one detectable label selected from the group consisting of 131I, 123I, 124I, 125I, 76Br, 75Br, 18F, 19F, 11C, 13C, 14C and 3H are provided as amyloid...
8228194 Recharging apparatus  
An energy harvesting circuit has an active automatic tuning circuit to search for broadcast frequencies in a band of interest and selecting only those broadcast signals received with sufficient RF...
US20120184845 AUTOMATED MACULAR PATHOLOGY DIAGNOSIS IN THREEDIMENSIONAL (3D) SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) IMAGES  
Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of...
US20120178702 STABLE LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
US20120177572 AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or...
US20120172240 GENETIC POLYMORPHISMS ASSOCIATED WITH ADVANCED LUNG DISEASES  
The present invention relates to methods and compositions that may be used to predict the risk of an individual, for example a smoker, for developing chronic obstructive pulmonary disease...
8214012 Magnetic resonance imaging having patient video, microphone and motion tracking  
Critical needs for MRI patient instruction, testing, comfort, motion control, and speech communication are provided for better imaging which leads to more effective medical care. An MRI Digital...
8213201 Motion activated amplifier  
An electronic device that includes a motion activated amplifier structured to receive a first DC signal having a first DC voltage level and output a second DC signal having a second DC voltage...
8211652 FSTL-1 as a biomaker of inflammation  
The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1...
8211436 Anticancer vaccine and diagnostic methods and reagents  
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the...
8211423 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
8211020 Combining tomographic images in situ with direct vision in sterile environments  
A device for combining tomographic images with human vision using a half-silvered mirror to merge the visual outer surface of an object (or a robotic mock effector) with a simultaneous reflection...
US20120164740 FLUORESCENT CHEMODOSIMETERS FOR MERCURY IONS BASED ON THE OXYMERCURATION OF VINYL ETHERS  
The present invention is a method to produce and to use a fluorogenic chemodosimeter for the detection of mercury ions in a sample at temperature ranges from about 0° C. to 100° C.
US20120157877 STEADY STATE MEASUREMENT AND ANALYSIS APPROACH TO PROFILING AUDITORY EVOKED POTENTIALS FROM SHORT-LATENCY TO LONG LATENCY  
The present invention relates to methods and systems for profiling evoked potentials in brain electrical activity which apply steady state response concepts to analysis of longer latency responses...
US20120156665 Real-Time X-Ray Vision for Healthcare Simulation  
A medical procedure training system and method for using is provided. The system includes a sensing system structured to detect the position and motion of a medical device inserted into a...
US20120156176 THERMORESPONSIVE, BIODEGRADABLE, ELASTOMERIC MATERIAL AND USES THEREFOR  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers...
8204836 Dynamic discrete decision simulation system  
A system that enables dynamic discrete decision simulation is provided. Simulation has many advantages in modeling complex systems to facilitate decision making. The innovation discloses a system...
8202510 Biomarkers for amyotrophic lateral sclerosis  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining...
US20120148676 ARTIFICIAL CELL CONSTRUCTS FOR CELLULAR MANIPULATION  
The present invention contemplates induction of immunological tolerance thereby providing permanent allogcaft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20120148598 METHODS FOR TREATING A TUMOR USING AN ANTIBODY THAT SPECIFICALLY BINDS GRP94  
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer...
US20120148494 ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS  
Benzofuran compounds which contain at least one detectable label selected from the group consisting of 131I, 123I, 124I, 76Br, 75Br, 18F, 19F, 11C, 13C, 14C and 3H are provided as amyloid imaging...
US20120147359 COMBINING TOMOGRAPHIC IMAGES IN SITU WITH DIRECT VISION IN STERILE ENVIRONMENTS  
A device for combining tomographic images with human vision using a half-silvered mirror to merge the visual outer surface of an object (or a robotic mock effector) with a simultaneous reflection...
8200318 Electrocardiogram reconstruction from implanted device electrograms  
A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an...
8198039 Biosensors and related methods  
Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor...
US20120143347 Elastomeric, Polymeric Bone Engineering and Regeneration Compositions and Methods of Making  
The invention relates to elastomeric, polymeric bone substitute compositions, methods for their preparation and their use in clinical applications, such as bone engineering and regeneration...
US20120141549 OLIGONUCLEOTIDES TARGETING ASTHMA INFLAMMATION PROCESSES  
The present invention relates to methods and compositions for inhibiting inflammatory processes (such as asthma) in the lungs, wherein oligonucleotides targeting IgE receptors and NfkappaB are...
US20120141432 USE OF CATALYTIC ANTIOXIDANT TO PRESERVE STEM CELL PHENOTYPE AND CONTROL CELL DIFFERENTIATION  
Methods are disclosed herein for maintaining stem cells in an undifferentiated state in vitro. The methods include contacting the stem cells with an effective amount of a catalytic antioxidant....
US20120141428 MUSCLE-DERIVED CELLS (MDCS) FOR TREATING MUSCLE- OR BONE-RELATED INJURY OR DYSFUNCTION  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
US20120136034 FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS  
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In...
US20120135971 ESTROGEN ANTAGONISTS AS TREATMENTS FOR SCLEROSING DISORDERS  
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen...
US20120135951 3'-AZIDO PURINE NUCLEOTIDE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The...