Patents and Patent Applications from University of Pittsburgh


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US20140329702 METHOD OF AMPLIFYING A NUCLEIC ACID  
A nucleic acid amplification method is provided, along with kits useful in performing the amplification method.
US20140329256 Urinary Biomarkers For Predicting Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
8878596 Hierarchical single molecule switch based on stimulated internal cluster motion within a hollow molecular cage  
Systems and methods related to single molecule switching devices are disclosed. One example method can include the step of applying a tunneling current across a tunneling junction. The tunneling...
8877728 Genetic changes in ATM and ATR/Chek1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20140323343 BIOMARKERS FOR ASSESSING IDIOPATHIC PULMONARY FIBROSIS  
Disclosed are methods are kits for evaluating predicting whether an individual IPF has slowly or rapidly progressive IPF.
US20140323322 METHOD AND APPARATUS FOR CHEMICAL SENSING USING 2D PHOTONIC CRYSTAL ARRAYS  
A chemical sensor comprising: a hydrogel layer, comprising one or more molecular recognition agents and a 2DPC self-assembling array; and a mirror layer. A method for analyzing a sample or bodily...
US20140322275 TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEPTOR  
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII,...
US20140321798 OPTICAL SENSOR EMPLOYING A REFRACTIVE INDEX ENGINEERED METAL OXIDE MATERIAL  
An optical sensor device includes an optical waveguide portion having a core, the core having a first refractive index, and a functional material layer coupled to the optical fiber portion, the...
US20140318990 pH SENSOR SYSTEM AND METHODS OF SENSING pH  
A system for measuring pH includes a substrate and a sensor medium on the substrate. The sensor medium includes at least one oxidized carbon nanostructure and optionally at least one composition...
8871831 Modification of surfaces with polymers  
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
US20140316242 QUANTIFIED INJURY DIAGNOSTICS  
A new and/or novel image analysis technique for quantitative assessment of motion-based testing for injury in a patient using universally available and affordable devices and techniques is...
US20140314816 STABILIZED STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFORE  
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are...
US20140314758 IMMUNOGENIC TUMOR ASSOCIATED STROMAL CELL ANTIGEN PEPTIDES AND METHODS OF THEIR USE  
Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides are useful for methods of eliciting...
8864027 Low-power pulse width encoding scheme and counter-less shift register that may be employed therewith  
A method of decoding an encoded signal includes steps of receiving the encoded signal, creating a decoding signal by delaying the encoded signal by a predetermined amount of time Δ, sampling the...
US20140309739 JOINT BIOSCAFFOLDS  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
US20140309726 BIODEGRADABLE VASCULAR GRAFTS  
Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed. In some...
US20140309303 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its...
US20140308362 INJECTABLE SILK FIBROIN PARTICLES AND USES THEREOF  
The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such...
US20140307226 OPTICAL COHERENCE TOMOGRAPHY AS A RAPID, ACCURATE, NON-CONTACT METHOD OF VISUALIZING THE PALISADES OF VOGT  
The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the...
8859488 Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response  
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
8859263 Method and apparatus for holding cells  
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown,...
US20140302548 MULTIPARAMETRIC METHOD FOR ASSESSING IMMUNE SYSTEM STATUS  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
8852923 Flow-stretch-flexure bioreactor  
Described herein is a bioreactor system and modules capable of developing physiologically relevant fluid-induced shear stresses and regionally specific flow patterns to scaffold specimens and...
US20140296695 SELECTIVE ZERO-QUANTUM COHERENCE TRANSFER (SEL-ZQC) METHOD FOR METABOLITE IMAGING IN A POORLY SHIMMED MAGNET FIELD WITHOUT SUSCEPTIBILITY ARTIFACT  
Systems and methods employing spin editing techniques to improve magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) are discussed. Using these spin editing...
US20140296294 NOVEL CANNABINOID RECEPTOR 2 (CB2) INVERSE AGONISTS AND THERAPEUTIC POTENTIAL FOR MULTIPLE MYELOMA AND OSTEOPOROSIS BONE DISEASES  
Cannabionid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are independently H, alkyl, or alkenyl; R3...
US20140294918 Matricryptic ECM Peptides for Tissue Reconstruction  
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in...
US20140294270 DIRECTIONAL DIFFUSION FIBER TRACKING  
Systems and methods facilitating high definition fiber tracking are disclosed. These systems and methods can utilize a directional Axonal Volume (dAV) value that can quantify the direction and...
8846341 Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation  
The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other...
8846098 Artificial cell constructs for cellular manipulation  
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive...
US20140288642 ARTIFICIAL VALVED CONDUITS FOR CARDIAC RECONSTRUCTIVE PROCEDURES AND METHODS FOR THEIR PRODUCTION  
Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve...
US20140287243 SUPERHYDROPHOBIC COATINGS  
A coating composition comprising a colloidal suspension comprising a fluoropolymer and fluorophilic particles in a liquid solvent, wherein the solvent comprises a fluorocarbon, a semifluorous...
US20140286562 Segmenting Biological Structures from Microscopy Images  
A method performed by one or more processors, includes: receiving an image to be segmented into one or more representations of one or more biological structures; accessing data representing a set...
8834423 Dissolvable microneedle arrays for transdermal delivery to human skin  
A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the...
US20140257075 MEASURING AQUEOUS HUMOR OUTFLOW  
Technologies are provided to estimate in vivo aqueous humor outflow for a subject. The method can include: preparing a virtual casting of the outflow network of the subject by use of background...
US20140256801 PERIPHERALLY DELIVERED GLUTAMIC ACID DECARBOXYLASE GENE THERAPY FOR SPINAL CORD INJURY PAIN  
The invention provides a method of treating spinal cord injury pain or peripheral neuropathic pain in a mammal comprising administering to a mammal a vector comprising a nucleotide sequence...
US20140256654 BIFUNCTIONAL COMPOUNDS  
A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl...
US20140255952 DEGRADABLE CARBON NANOTUBE-CONTAINING BIOSENSORS AND METHODS FOR TARGET CLINICAL MARKER DETECTION  
The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The...
8831304 Blood vessel segmentation with three-dimensional spectral domain optical coherence tomography  
In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to...
8827943 Catheter  
In one aspect, the invention provides a device comprising a catheter. In another aspect, the invention provides a method of removing an agent from blood.
US20140249595 Methods and Systems for Achieving a Physiological Response by Pudendal Nerve Stimulation and Blockade  
Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The...
US20140249427 DEPTH-SELECTIVE FIBER-OPTIC PROBE  
Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can...
US20140249209 METHODS FOR THE TREATMENT AND PREVENTION OF LIVER DISEASE  
The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an...
US20140248288 BIODEGRADABLE METAL ALLOYS  
The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components,...
US20140248232 BIODEGRADABLE, NON-THROMBOGENIC ELASTOMERIC POLYURETHANES  
A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the...
8822571 High refractive index crystalline colloidal arrays materials and a process for making the same  
Disclosed are a new composite material and a process for synthesizing highly charged, highly monodisperse, core-shell particles with high refractive index cores, as well as stable, long lasting...
8822541 Use of targeted nitroxide agents in mitigating or treating radiation injury  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20140243911 BIODEGRADABLE, MAGNESIUM-CONTAINING BONE SCREWS, METHODS FOR THEIR PREPARATION AND MEDICAL APPLICATIONS THEREFOR  
The invention relates to a biodegradable, magnesium-containing bone screw for implanting into a patient body for use in medical applications, such as, orthopedic, craniofacial and cardiovascular...
US20140243215 METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
8818557 Cortical control of a prosthetic device  
A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and...
8815946 Inhibition of proliferation and fibrotic response of activated corneal stromal cells  
Provided herein are methods of preventing a fibrotic response and/or scarring in a wound, comprising administering to a subject a composition comprising an amount of an amide or ester of an...