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Patents and Patent Applications from University of Pittsburgh


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7718603 Selective targeting agents for mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20100121273 Emergency preservation and resuscitation methods  
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods...
7711174 Methods and systems for imaging cells  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
7704507 Anticancer vaccine and diagnostic methods and reagents  
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the...
7704503 Use of IL-17F in diagnosis and therapy of airway inflammation  
The invention is related to findings that IL-17F-mediated inflammation of airway passages may be mediated via signaling through IL-17R on the basolateral surface of human respiratory epithelial...
US20100100510 DYNAMIC DISCRETE DECISION SIMULATION SYSTEM  
A system that enables dynamic discrete decision simulation is provided. Simulation has many advantages in modeling complex systems to facilitate decision making. The innovation discloses a system...
7702140 Method of assessing a body part  
A method of assessing a body part includes obtaining two or more types of data through a combination of two or more of the following four imaging modalities: (1) obtaining surface topography data...
7700794 Fluorous tagging compounds and methods of increasing the fluorous nature of compounds  
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group, Rs is a...
7695909 Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26  
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of...
7691416 Methods of treating vascular disease  
The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical...
US20100081192 EARLY PROSTATE CANCER ANTIGENS (EPCA), POLYNUCLEOTIDE SEQUENCES ENCODING THEM, AND THEIR USE  
A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without...
US20100081148 Urinary Biomarkers To Predict Long-Term Dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
US20100078599 Nanoscale Silicon-Based Compositions and Methods of Preparation  
The present invention is related to nano-particle compositions, methods of their preparation and applications thereof. The nano-particle compositions include silicon-containing nano-particles, a...
7687079 Methods of treating ileus  
The present invention relates to a method of treating ileus in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
US20100073188 System and Method for Real Time Asset Location and Tracking  
A system for estimating the current position of an asset within a location that includes a transponder associated with the asset, a plurality of wireless interface devices provided within the...
US20100072424 LANTHANIDE METAL-ORGANIC FRAMEWORKS AND USES THEREOF  
Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new...
7678057 Device and system that identifies cardiovascular insufficiency  
In an embodiment, the present invention provides a device that identifies cardiovascular dysfunction of a subject. The claimed device comprises a controller, a transducer, and a processor. The...
7672732 Portable apparatus that delivers power and information to implantable devices  
An apparatus for powering an implant includes first energy interface elements, a removeably attachable holding device and a first energy source, such as a battery. An energy conversion circuit...
US20100048682 INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS  
The invention provides anticancer methods. In one embodiment, the inventive method involves the co-administration to cancerous cells of (a) a chemotherapeutic agent, radiation, or a combination of...
US20100047841 SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF  
Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as...
7662793 Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from a Pol III promoter  
A nucleic acid is provided comprising an expression cassette which includes transcription control sequences of a member of a class of Pol III-transcribed genes in which no transcribed portion of...
7662566 Gene copy number profiling  
The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a...
7662561 Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma  
Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided....
US20100035869 TARGETED NITROXIDE AGENTS  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20100030101 Method And System For Acquiring Loudness Level Information  
The present invention relates to methods for acquiring hearing threshold values in a subject comprising providing a sound to the subject; providing a monitor for monitoring a movement response by...
7655640 Camptothecin analogs and methods of preparation thereof  
A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable...
7655468 Stable lipid-comprising drug delivery complexes and methods for their production  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
7655461 Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen  
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility...
7655216 Vaccine for activating helper function of CD8+ Tcells  
The invention provides compositions and methods for treating or preventing a target disease in a mammal by induction of memory T cells. The methods comprise (1) administering a sensitizing...
US20100022520 MALONYL-COA ACETYLTRANSFERASE INHIBITORS AGAINST ANTIBIOTIC RESISTANT BACTERTIA  
Compounds characterized by thiolactone or thiomorpholino cores display useful antibiotic and radioprotective properties. The latter properties are believed to arise from an ability of the compounds...
US20100021388 BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
US20100019207 Ternary Metal Transition Metal Non-Oxide Nano-Particles, Methods and Applications Thereof  
The present invention is related to ternary metal transition metal non-oxide nano-particle compositions, methods for preparing the nano-particles, and applications relating in particular to the use...
US20100018920 REACTION AND SEPARATION METHODS  
A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second...
US20100008940 PEPTIDE ANALOGS CAPABLE OF ENHANCING STIMULATION OF A GLIOMA-SPECIFIC CTL RESPONSE  
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for ...
US20100002929 Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation  
The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell...
US20090326070 VINYL SUBSTITUTED FATTY ACIDS  
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty...
US20090325214 NUCLEAR MATRIX PROTEIN ALTERATIONS ASSOCIATED WITH COLON CANCER AND THEIR USE AS MARKERS FOR COLORECTAL CANCER  
CCSA-2 levels in serum samples from individuals suffering from colorectal cancer can be used gauging the progression of a colorectal cancer condition. In particular, the progression of a colorectal...
US20090318309 Thermo-reversibly gelled colloidal suspensions and a process for making the same  
Disclosed is a thermoreversible synthesis of a new type of material made by embedding a colloidal population within a thermo-reversibly gelled polymer. The polymer may be a physically cross-linked...
US20090310393 Motion Activated Amplifier  
An electronic device that includes a motion activated amplifier structured to receive a first DC signal having a first DC voltage level and output a second DC signal having a second DC voltage...
US20090309344 RESTRAINT SYSTEMS FOR USE IN VEHICLES AND METHODS OF RESTRAINT  
A safety restraint system to restrain a wheelchair-seated person in a vehicle includes a belt including a pelvic restraining portion connectable between a first side and an second side. The system...
US20090306027 GENETIC RISK ASSESSMENT IN HEART FAILURE: IMPACT OF THE GENETIC VARIATION OF G-PROTEIN BETA 3 SUBUNIT POLYMORPHISM  
The invention provides methods for treating various indications and diseases in a patient in need thereof, wherein the patient has a C825T polymorphism in the G protein beta3 subunit (GNB3),...
7629315 Compositions for blocking the inhibitory effect of human CRP on human leptin  
Leptin controls the production of C-Reactive Protein (CRP), which, in turn, interacts with leptin to diminish its ability to signal satiety and reduce food intake. The interactions between leptin...
7628888 Cellulosic composition  
A composition includes at least one hydrophilic polymer containing primary (—NH2) and/or secondary (—NHR) amine groups and at least one saccharide containing a reducible function. A method of inc...
US20090299948 IDENTIFICATION AND MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS  
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
US20090298198 DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS  
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
US20090298193 ATOMIC EMISSION SPECTROSCOPY ON A CHIP  
A method of inducing explosive atomization of materials is provided using a metal-oxide-semiconductor (MOS)-based structure under electrical excitation. Explosive atomization of the gate electrode...
US20090297567 Method For Ultrasound Triggered Drug Delivery Using Hollow Microbubbles With Controlled Fragility  
A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The...
US20090291145 MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES  
A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are targeted to bind to primary transcripts...
US20090277805 ELECTROCHEMICAL SENSORS, SENSOR SYSTEMS AND METHOD OF SENSING ANALYTES  
A sensor, includes a working electrode including a first layer formed of a polymeric material. The first layer includes a first surface across which an analyte in a sample can be transported and a...
US20090274628 RECONSTITUTABLE MICROSPHERE COMPOSITIONS USEFUL AS ULTRASONIC CONTRAST AGENTS  
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...