Patents and Patent Applications from University of Pittsburgh


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US20150119468 PROTECTION FROM CHEMICAL-INDUCED ACUTE LUNG INJURY  
Methods are provided herein for treating an individual having a disease, disorder or condition affecting the lungs, wherein said disease, disorder, or condition of the lung is an acute lung...
9017260 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
US20150112144 ADAPTIVE OPTICAL LASER BEAM STEERING THROUGH ENDOSCOPE FOR LASER SURGERY IN KIDNEY  
A lightguide is configured to transmit a scanned and/or focused processing beam to a target. The processing beam has a wavefront amplitude and phase set by a spatial light modulator. Suitable...
US20150105882 INERTIAL MEASUREMENT OF SPORTS MOTION  
Systems and methods of motion tracking are disclosed that can be used in connection with sports motion. Such a method can include placing one or more inertial measurement units (IMUs) on at least...
US20150104807 KITS FOR DIAGNOSTIC AND THERAPEUTIC USES OF AUGMENTER OF LIVER REGENERATION IN INFLAMMATORY CONDITIONS  
The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver...
US20150101938 Measurement device with automated calibration  
A system for obtaining a pH measurement comprises a disposable probe and a reusable reader. The disposable probe includes an indicating electrode and a reference electrode. The reader operably...
9006186 Selective targeting agents for mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20150094564 INTELLIGENT ALGORITHMS FOR TRACKING THREE-DIMENSIONAL SKELETAL MOVEMENT FROM RADIOGRAPHIC IMAGE SEQUENCES  
Systems and methods are disclosed that improve conventional tracking and modeling methods for determining three-dimensional bone motion from sequences of radiographic images. These enhancements...
US20150094547 SYSTEM AND METHOD FOR STORING INFORMATION RELATING TO A MEDICAL IMPLANT DEVICE  
A method of storing information relating, to a medical implant device having a number of implant elements includes receiving a first image, the first image showing a surgical site and the medical...
US20150093821 BIODEGRADABLE POLYURETHANES AND USE THEREOF  
A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at...
8993744 Universal dengue virus sequences and methods of use  
Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments...
US20150088183 SURGICAL TOOL MONITORING SYSTEM AND METHODS OF USE  
A device for simultaneously monitoring the health of surgical drills and detecting proximity to critical structures during surgery is described herein. By using various sensors (e.g. microphones,...
US20150086977 GRAPHENE COMPOSITION, METHOD OF FORMING A GRAPHENE COMPOSITION AND SENSOR SYSTEM COMPRISING A GRAPHENE COMPOSITION  
A device including a composition formed by oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide. A composition includes...
US20150086535 Use of Survivin Antagonists in Polyomavirus-Related Disease  
A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient is provided, comprising administering to the patient a therapeutically effective amount of a...
8986671 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150081328 SYSTEM FOR HOSPITAL ADAPTIVE READMISSION PREDICTION AND MANAGEMENT  
A method of determining a probability of readmission of a patient includes receiving patient data from a plurality of information sources; calculating the probability of readmission of the patient...
US20150080229 PLASMA MICRORIBONUCLEIC ACIDS AS BIOMARKERS FOR ENDOMETRIOSIS AND ENDOMETRIOSIS-ASSOCIATED OVARIAN CANCER  
The present invention relates to methods and compositions for differentiating between absence of disease, endometriosis, and EAOC or serous ovarian cancer in a subject. It is based, at least in...
US20150079026 Controlled Release Formulations for the Induction and Proliferation of Blood Cells  
The absence of regulatory T cells (Treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of Treg...
8981914 Portable haptic force magnifier  
An improved system for magnifying forces perceived by an operator performing delicate procedures with a tool. The system senses forces between the tip and handle of the tool and actuates forces...
US20150073290 DETECTION OF ACETONE VIA NANOSTRUCTURE SENSORS  
A method of detecting at least one of analyte in an environment (such as in breath) includes providing a structure including nanostructures in contact with titanium dioxide, applying...
US20150071887 Soft Tissue and Bone Augmentation and Bulking Utilizing Muscle-Derived Progenitor Cells, Compositions and Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
8974542 Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions  
Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The...
US20150065488 METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN POLYMERIZATION  
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine,...
US20150065443 EMBELIN-BASED DELIVERY SYSTEM FOR WATER-INSOLUBLE ACTIVE AGENTS  
A composition having a structure of: X-L-Y wherein X comprises at least one embelin moiety;L comprises a linker; andY comprises a hydrophilic moiety.Also disclosed is a micelle that includes:a...
US20150064724 BIOMARKERS FOR PROGNOSES OF PULMONARY DISEASES  
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic...
US20150064136 PREDICTORS OF PATIENT RESPONSE TO INTERFERON-A THERAPY  
The present invention relates to methods and materials for more effectively treating patients with interferon. It is based on the discovery that clinical response to interferon (IFN) therapy is...
8969326 Estrogen antagonists as treatments for sclerosing disorders  
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen...
US20150056217 USE OF TOLL-LIKE RECEPTOR-9 AGONISTS, TOLL-LIKE RECEPTOR-4 ANTAGONISTS, AND/OR NUCLEAR OLIGOMERIZATION DOMAIN-2 AGONISTS FOR THE TREATMENT OR PREVENTION OF TOLL-LIKE RECEPTOR-4 ASSOCIATED DISORDERS  
The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic...
8962570 Therapeutic use of peptide inhibitors of NADPH oxidase; aerosolization as a delivery mechanism  
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit...
8961954 Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20150050647 Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse  
The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a...
8957036 Targeted delivery of glycine receptors to excitable cells  
The invention provides a method of modulating electrophysiological activity of an excitable cell. The method involves causing exogenous expression of a glycine receptor (GlyR) protein in an...
US20150045412 USE OF THE CHROMOSOME 19 MICRORNA CLUSTER (C19MC) FOR TREATING MICROBIAL DISEASE AND PROMOTING AUTHOPHAGY  
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental...
US20150045304 BONE SUBSTITUTE NANOCOMPOSITES AND METHODS OF SYNTHESIS USING MULTIPHOSPHORYLATED PEPTIDES  
The invention relates to peptides including DEDE(SSD)nDEG indicated by SEQ NO. 1, RRRDEDE(SSD)nDEG indicated by SEQ No. 2, RRRGDEDE(SSD)nDEG indicated by SEQ No. 3, and LKKLKKLDEDE(SSD)nDEG...
US20150044655 DRUG SIMULANT RECOGNITION SYSTEM AND METHOD OF EMPLOYING  
A system for identifying a drug simulant includes an electronic sensing system structured to measure the value of an inherent property of the drug simulant; a processing unit in electrical...
US20150044247 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H3N2, H2N2, AND B INFLUENZA VIRUSES  
Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA...
US20150044185 Bone Augmentation Utilizing Muscle-Derived Progenitor Compositions in Biocompatible Matrix, and Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
US20150038561 MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF  
Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped,...
US20150038468 ESTROGEN ANTAGONISTS AS TREATMENTS FOR SCLEROSING DISORDERS  
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen...
8945538 Bone substitute compositions, methods of preparation and clinical applications  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium...
8944939 Inertial measurement of sports motion  
Systems and methods of motion tracking are disclosed that can be used in connection with sports motion. Such a method can include placing one or more inertial measurement units (IMUs) on at least...
US20150030628 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR INFLUENZA  
The development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates is described. The optimized HA protein was...
8940277 Intracellular microbubble for imaging an anatomical site  
This invention addresses the clinical problem of how to optimize biological cell based therapies, such as stem cell therapy. Currently, cell therapies administered by intravenous, intra-arterial,...
8937086 Compounds for the treatment of pathologies associated with aging and degenerative disorders  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
US20150018417 FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS  
A class of enzymatically generated electrophilic fatty acid derivatives (EFADs), or their enzymatically generated metabolites. The EFAD's and their metabolites have beneficial effects human...
US20150018346 COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
US20150017262 INHIBITION OF DYNAMIN RELATED PROTEIN 1 TO PROMOTE CELL DEATH  
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i)...
US20150017220 Rapid Preparation of Stem Cell Matrices for Use in Tissue and Organ Treatment and Repair  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
US20150017196 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H5N1 AND H1N1 INFLUENZA VIRUSES  
Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides...
US20150010919 Polysiloxane Substrates with Highly-Tunable Elastic Modulus  
A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for...