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Patents and Patent Applications from University of Pittsburgh


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US20110184439 Biological Matrix for Cardiac Repair  
Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive...
US20110184171 ACYLATION OF HINDERED AMINES AND FUNCTIONALIZED BIS-PEPTIDES OBTAINED THEREBY  
Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable nanostructures...
US20110176716 ESTABLISHING COMPATIBILITY BETWEEN TWO- AND THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY SCANS  
Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional...
7982041 Camptothecin analogs and methods of preparation thereof  
A compound having the formula in racemic form, enantiomerically enriched form or enantiomerically pure form, and pharmaceutically acceptable salts thereof.
7981448 Methods of treating necrotizing enterocolitis  
The present invention relates to a method of treating necrotizing enterocolitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
7981038 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position...
US20110172930 DISCOVERY OF t-HOMOLOGY IN A SET OF SEQUENCES AND PRODUCTION OF LISTS OF t-HOMOLOGOUS SEQUENCES WITH PREDEFINED PROPERTIES  
System(s) and method(s) for analysis and design of genome sequences are provided. A graph representation of a genome sequence facilitates generation of a thermodynamic based quantity, e.g., an...
US20110172214 USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20110171650 GENE EXPRESSION RELATED TO PREECLAMPSIA  
Gene expression patterns contemporaneous with early placental development in the first trimester of preeclamptic versus unaffected pregnancies have been obtained. Observation of differences in...
US20110171229 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20110171170 CYTOTOXIC T CELL DEFINED EGFR PEPTIDE AND AN OPTIMIZED DERIVATIVE PEPTIDE  
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid,...
US20110168559 Nanoscale Surface Plasmonics Sensor with Nanofluidic Control  
A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing...
US20110165088 NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR LYMPHATIC SYSTEM  
A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they...
US20110162905 STEERING MECHANISM FOR A PERSONAL VEHICLE  
Steering mechanism that increases adjustability. The steering mechanism can have different gear ratios between the input rotation from the user and the output rotation on the drive wheel. The...
US20110162166 MOBILE CASTER  
Caster alignment mechanism having a first component operably connected to a leg of a mobile device and a second component operably connected to a caster of the mobile device. The first and second...
7972599 Immunomodulation of inflammatory conditions utilizing Follistatin-like protein-1 and agents that bind thereto  
Follistatin-like protein (FSTL-1) is a secreted glycoprotein of unknown function, first isolated from mouse osteoblastic cells as a transforming growth factor-β1-inducible gene. The inventors have ...
US20110160160 METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT  
The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective...
7968736 Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof  
A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom;R2 is H, an alkyl group, an aryl group, a benzyl group,...
US20110154510 AUTOMATED HIGH-CONTENT LIVE ANIMAL DRUG SCREENING USING C. ELEGANS  
The present invention relates to methods and compositions for high content drug screening in C. elegans which may be used to identify compounds that treat disorders associated with protein...
7964574 Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
US20110137291 USE OF RELAXIN TO INCREASE ARTERIAL COMPLIANCE  
The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present...
US20110135598 METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA  
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a...
US20110129551 SOLUBLE CD117 (SC-KIT) FOR DIAGNOSIS OF PREECLAMPSIA AND ECLAMPSIA  
This disclosure relates to methods of predicting and diagnosing preeclampsia and eclampsia in pregnant subjects. These methods include detecting a decrease of soluble c-kit in a sample obtained...
US20110127446 NANOSTRUCTURE SYSTEMS AND METHODS FOR SENSING AN ANALYTE  
A method of detecting an analyte in an environment, includes immobilizing at least one photoactive composition on nanostructures, the photoactive composition exhibiting emission that is sensitive...
US20110125238 METHODS, DEVICES AND SYSTEMS FOR TREATING INSOMNIA BY INDUCING FRONTAL CEREBRAL HYPOTHERMIA  
Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to...
US20110123286 WHEELED MOBILITY DEVICE CONTAINMENT SYSTEMS AND OCCUPANT RETENTION SYSTEMS AND METHODS OF CONTAINING WHEELED MOBILITY DEVICES AND RETAINING OCCUPANTS THEREOF  
A system to contain a wheeled mobility device in a vehicle, includes: a rearward opening to allow access by the wheeled mobility device by moving the wheeled mobility device forward relative to the...
US20110118214 LIGANDS SPECIFIC FOR CANNABINOID RECEPTOR SUBTYPE 2  
A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or...
US20110111656 DURABLE SUPERHYDROPHOBIC COATINGS  
Durable superhydrophobic coating composition having a composition ranging from about 10 to about 80 w.t. % of an acrylic polymer resin, from about 5 to about 40 w.t. % of a polysiloxane oil, from...
US20110111437 Biomarkers For Prognosis of Pulmonary Diseases  
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic...
US20110110941 Wortmannin Analogs and Methods of Using Same in Combination with Chemotherapeutic Agents  
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the...
US20110104739 BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the...
US20110104694 COMPOSITIONS AND METHODS FOR DETECTING CANCER  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
US20110104213 Porous Biomolecule-Containing Metal-Organic Frameworks  
The present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic...
US20110103312 Methods and Apparatus for Switching A Transponder To an Active State, and Asset Management Systems Employing Same  
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
US20110101788 Wireless Energy Transfer System  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load....
US20110098651 DISSOLVABLE MICRONEEDLE ARRAYS FOR TRANSDERMAL DELIVERY TO HUMAN SKIN  
A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the...
7933861 Process data warehouse  
Systems and/or methods are presented that can efficiently analyze and summarize large collections of data. A summarization component can employ mapping rules to map received data into specified...
US20110091957 PROTEIN-POLYMER CONJUGATES AND SYNTHESIS THEREOF  
A method of synthesizing a protein-polymer conjugate includes the steps: covalently attaching at least one controlled radical polymerization initiator to a protein to form a protein-initiator...
US20110091908 EARLY PROSTATE CANCER ANTIGEN-2: A NOVEL SERUM SPECIFIC MARKER FOR PROSTATE CANCER DETECTION  
Early Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall...
7927544 Paracorporeal respiratory assist lung  
A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is...
US20110086909 SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
US20110086894 BIOMARKERS FOR THE DIAGNOSIS OF ALS  
Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative...
7920736 Methods and systems for imaging cells  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
US20110064703 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
7907769 Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation  
The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell...
7906110 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
The invention is directed to preparation of stem cell and physiologically acceptable matrix compositions. Compared with previous tissue engineering materials, the stem cell-matrix compositions of...
US20110060461 Cortical Control of a Prosthetic Device  
A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and...
7902272 Highly diffracting, color shifting, polymerized crystalline colloidal arrays of highly charged polymer spheres, paints and coatings and processes for making the same  
One aspect of the present disclosure is directed towards a new film forming paint that Bragg diffracts light in the visible and NIR spectral regions. The paint may be comprised of highly charged...
7897569 Use of HMGB fragments as anti-inflammatory agents  
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
7897326 Peroxisome-proliferator activated receptor-alpha agonists for organ preservation  
Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) ...