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Patents and Patent Applications from University of Pittsburgh


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7927544 Paracorporeal respiratory assist lung  
A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is...
US20110086909 SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
US20110086894 BIOMARKERS FOR THE DIAGNOSIS OF ALS  
Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative...
7920736 Methods and systems for imaging cells  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
US20110064703 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
7907769 Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation  
The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell...
7906110 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
The invention is directed to preparation of stem cell and physiologically acceptable matrix compositions. Compared with previous tissue engineering materials, the stem cell-matrix compositions of...
US20110060461 Cortical Control of a Prosthetic Device  
A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and...
7902272 Highly diffracting, color shifting, polymerized crystalline colloidal arrays of highly charged polymer spheres, paints and coatings and processes for making the same  
One aspect of the present disclosure is directed towards a new film forming paint that Bragg diffracts light in the visible and NIR spectral regions. The paint may be comprised of highly charged...
7897569 Use of HMGB fragments as anti-inflammatory agents  
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
7897326 Peroxisome-proliferator activated receptor-alpha agonists for organ preservation  
Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) ...
US20110045507 FSTL-1 AS A BIOMAKER OF INFLAMMATION  
The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1...
US20110039792 Selective Targeting Agents for Mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20110039277 Methods of Labeling Proteins  
Methods are provided for labeling specific oxidized proteins. Methods also are provided for determining the oxidation state of a cell. Such methods are useful as diagnostic, therapeutic and...
7887792 Muscle-derived cells (MDCs) for treating muscle- or bone-related injury or dysfunction  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
7884085 Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
7882909 Personal vehicle  
A personal vehicle comprises a frame with a seat, two large, non-drive wheels connected by an axle at one end of the frame, an elongated swing arm attached to the axle, a pair of caster wheels...
US20110028961 EMERGENCY PRESERVATION AND RESUSCITATION METHODS  
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods...
7878978 Use of relaxin to increase arterial compliance  
The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present...
7876225 Methods and apparatus for switching a transponder to an active state, and asset management systems employing same  
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
US20110012728 Sensor and System to Detect Bridge Scour  
A system for detecting scour associated with a structure having a part thereof extending into a bed of material located under a body of water is provided. The system comprises a sensor unit buried...
7872027 Low molecular weight Myc-max inhibitors  
Compounds and compositions for interfering with the association of Myc and Max are described herein. These compounds and compositions are useful in methods inhibiting growth or proliferation of a...
US20110009899 TENSION TRANSDUCING FORCEPS  
A forceps device is provided for performing a surgical procedure. The device comprises a closeable jaw comprising jaw members having one or more force sensors deployed in a manner to measure force...
7867752 Method and apparatus for holding cells  
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown,...
US20110002899 Lymph Nodes as a Site for Regeneration  
Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
US20100331767 INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS  
A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft...
7858657 Wortmannin analogs and methods of using same in combination with chemotherapeutic agents  
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the...
7858071 Biomarkers for amyotrophic lateral sclerosis  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the...
US20100324112 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20100323029 FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE  
Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild...
US20100322909 TH1-ASSOCIATED MICRORNAS AND THEIR USE FOR TUMOR IMMUNOTHERAPY  
Described herein is the identification of miRNAs (miRs) that are up-regulated in Th1 cells compared to Th2 cells (referred to herein as Th1-associated miRs). In particular, the miR-17-92 gene...
7854920 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
US20100314575 ANTI-ICING SUPERHYDROPHOBIC COATINGS  
Superhydrophobic coating compositions are provided. The compositions comprise nanoparticles between 5-100 nm in size and a polymeric binder. The compositions are effective in preventing ice...
7851144 Compositions and methods for detecting cancer  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
US20100298352 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS  
A method of inhibiting a carcinoma in a subject, comprising administering to the subject at least one therapeutic agent that selectively targets carcinoma stem cells. Illustrative carcinoma stem...
US20100297158 ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS  
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the...
7838251 Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof  
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and...
US20100292149 Modulation of the Neuroendocrine System as a Therapy for Motor Neuron Disease  
The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a...
US20100292072 REGENERABLE SOLID IMINE SORBENTS  
Two new classes of amine-based sorbents are disclosed. The first class comprises new polymer-immobilized tertiary amine sorbents; the second class new polymer-bound amine sorbents. Both classes are...
US20100285489 METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
US20100282245 Detection of nitric oxide  
A system for the detection of nitric oxide in a gas sample includes a converter for oxidation of nitric oxide to nitrogen dioxide, a nitrogen dioxide sensor including nanostructures and a filtering...
7829536 Method of treating lymphedema comprising administering VEGF-D  
The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
7829097 Use of HMGB1 for protection against ischemia reperfusion injury  
Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1...
US20100279969 AZIDO PURINE NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The...
US20100276975 ANGLE ADJUSTABLE BACKREST MOUNTING  
Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of...
7825807 Transponder networks and transponder systems employing a touch probe reader device  
Transponder networks and transponder systems are provided which help to overcome the issues presented to transponders systems by FCC power limitations. One embodiment provides a transponder network...
7825267 Synthesis of FR901464 and analogs with antitumor activity  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
US20100260855 DELIVERY OF AS-OLIGONUCLEOTIDE MICROSPHERES TO INDUCE DENDRITIC CELL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE TYPE 1 DIABETES  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
US20100260406 METHODS AND SYSTEMS FOR IMAGING CELLS  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
US20100258116 DEVICES, SYSTEMS AND METHODS FOR REDUCING THE CONCENTRATION OF A CHEMICAL ENTITY IN FLUIDS  
A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized...