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Patents and Patent Applications from University of Pittsburgh


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US20110274758 MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
US20110274698 Immunomodulation Of Inflammatory Conditions Utilizing Follistatin-Like Protein-1 And Agents That Bind Thereto  
Follistatin-like protein (FSTL-1) is a secreted glycoprotein of unknown function, first isolated from mouse osteoblastic cells as a transforming growth factor-β1-inducible gene. The inventors have...
8053190 Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26  
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development...
US20110268695 USE OF HMGB FRAGMENTS AS ANTI-INFLAMMATORY AGENTS  
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
US20110265616 ULTRA-PURE, SINGLE-CRYSTAL SIC CUTTING TOOL FOR ULTRA-PRECISION MACHINING  
Systems and methods that use a single-crystal boule SiC sharpened into a cutting tool for ultra-precision machining of ferrous alloys are disclosed. Conventional ultra-precision machining uses...
US20110263116 ULTRAHIGH DENSITY PATTERNING OF CONDUCTING MEDIA  
A reconfigurable device and a method of creating, erasing, or reconfiguring the device are provided. At an interface between a first insulating layer and a second insulating layer, an electrically...
US20110262498 Biologic Scaffold for Prevention of Pulmonary Fibrosis  
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived...
8043411 Devices, systems and methods for reducing the concentration of a chemical entity in fluids  
A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized...
US20110257525 SENSOR GUIDED CATHETER NAVIGATION SYSTEM  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
US20110257407 THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions...
US20110245309 N-METHYLPURINE DNA GLYCOSYLASE AND POLYMERASE BETA AS BIOMARKERS FOR ALKYLATOR CHEMOTHERAPY POTENTIATION  
Described herein is the finding that polymerase β (Polβ) and N-methylpurine DNA glycosylase (MPG) can be used as biomarkers to evaluate the sensitivity of a subject to combination therapy that...
US20110244472 Cancer stem cell immortalization  
The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer...
US20110243900 SOFT TISSUE AND BONE AUGMENTATION AND BULKING UTILIZING MUSCLE-DERIVED PROGENITOR CELLS, COMPOSITIONS AND TREATMENTS THEREOF  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
8029774 Wound healing polymeric networks  
A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing...
8022826 Methods and apparatus for switching a transponder to an active state, and asset management systems employing same  
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
8022704 Method for producing a magnetic resonance image of an object having a short T2 relaxation time  
A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded...
8022046 Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes  
A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are targeted to bind to primary transcripts...
US20110223139 RAPID PREPARATION OF STEM CELL MATRICES FOR USE IN TISSUE AND ORGAN TREATMENT AND REPAIR  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
8012278 End-to-end joining of nanotubes  
A method for joining nanotubes end-to-end, includes contacting the nanotubes with a joining fluid. The joining fluid has at least one property that is different from at least one property...
US20110213237 ECHO-SPECIFIC K-SPACE REORDERING APPROACH TO COMPATIBLE DUAL-ECHO ARTERIOVENOGRAPHY  
A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo-specific K-space ordering scheme...
US20110213017 TARGETED DELIVERY OF GLYCINE RECEPTORS TO EXCITABLE CELLS  
The invention provides a method of modulating electrophysiological activity of an excitable cell. The method involves causing exogenous expression of a glycine receptor (GlyR) protein in an...
US20110212500 FLOW-STRETCH-FLEXURE BIOREACTOR  
Described herein is a bioreactor system and modules capable of developing physiologically relevant fluid-induced shear stresses and regionally specific flow patterns to scaffold specimens and...
US20110212473 MMP ACTIVATION PEPTIDE DETECTION IN BIOLOGICAL SAMPLES  
A method is provided along with related reagent kits for aiding the diagnosis of IPF or other interstitial lung diseases, as well as for potential monitoring of disease progression or therapeutic...
US20110212172 ADMINISTRATION OF AN ADSORBENT POLYMER FOR TREATMENT OF SYSTEMIC INFLAMMATION  
The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene...
8010193 Device and method to discriminate between supraventricular tachycardias and ventricular arrhythmias  
This invention provides a method to discriminate between ventricular arrhythmia and supraventricular tachycardia by detecting an earliest arriving electrical signal following antitachycardia...
8007504 Device and method of use for functional isolation of animal or human tissues  
A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the...
US20110208113 Directed Cell-Based Therapy Using Microbubble Tagged Cells  
The disclosed technology describes compositions and methods useful for providing cell based therapy. For example, one embodiment of cell based therapy involves the regeneration of injured tissue...
US20110206262 IMAGE-BASED METHODS FOR MEASURING GLOBAL NUCLEAR PATTERNS AS EPIGENETIC MARKERS OF CELL DIFFERENTIATION  
The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell...
US20110200608 FULLY HUMAN ANTIBODIES TO HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN AND USES THEREOF  
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including...
7999248 Ultrahigh density patterning of conducting media  
A nanoscale device and a method for creating and erasing of nanoscale conducting regions at the interface between two insulating oxides SrTiO3 and LaAlO3 is provided. The method uses the tip of a...
7993672 Stable lipid-comprising drug delivery complexes and methods for their production  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
7992999 Automated assessment of optic nerve head with spectral domain optical coherence tomography  
A fully automated optic nerve head assessment system, based on spectral domain optical coherence tomography, provides essential disc parameters for clinical analysis, early detection, and...
US20110190241 TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX  
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory...
US20110184439 Biological Matrix for Cardiac Repair  
Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive...
US20110184171 ACYLATION OF HINDERED AMINES AND FUNCTIONALIZED BIS-PEPTIDES OBTAINED THEREBY  
Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable...
US20110176716 ESTABLISHING COMPATIBILITY BETWEEN TWO- AND THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY SCANS  
Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional...
7982041 Camptothecin analogs and methods of preparation thereof  
A compound having the formula in racemic form, enantiomerically enriched form or enantiomerically pure form, and pharmaceutically acceptable salts thereof.
7981448 Methods of treating necrotizing enterocolitis  
The present invention relates to a method of treating necrotizing enterocolitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
7981038 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
US20110172930 DISCOVERY OF t-HOMOLOGY IN A SET OF SEQUENCES AND PRODUCTION OF LISTS OF t-HOMOLOGOUS SEQUENCES WITH PREDEFINED PROPERTIES  
System(s) and method(s) for analysis and design of genome sequences are provided. A graph representation of a genome sequence facilitates generation of a thermodynamic based quantity, e.g., an...
US20110172214 USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20110171650 GENE EXPRESSION RELATED TO PREECLAMPSIA  
Gene expression patterns contemporaneous with early placental development in the first trimester of preeclamptic versus unaffected pregnancies have been obtained. Observation of differences in...
US20110171229 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20110171170 CYTOTOXIC T CELL DEFINED EGFR PEPTIDE AND AN OPTIMIZED DERIVATIVE PEPTIDE  
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic...
US20110168559 Nanoscale Surface Plasmonics Sensor with Nanofluidic Control  
A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing...
US20110165088 NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR LYMPHATIC SYSTEM  
A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they...
US20110162905 STEERING MECHANISM FOR A PERSONAL VEHICLE  
Steering mechanism that increases adjustability. The steering mechanism can have different gear ratios between the input rotation from the user and the output rotation on the drive wheel. The...
US20110162166 MOBILE CASTER  
Caster alignment mechanism having a first component operably connected to a leg of a mobile device and a second component operably connected to a caster of the mobile device. The first and second...
7972599 Immunomodulation of inflammatory conditions utilizing Follistatin-like protein-1 and agents that bind thereto  
Follistatin-like protein (FSTL-1) is a secreted glycoprotein of unknown function, first isolated from mouse osteoblastic cells as a transforming growth factor-β1-inducible gene. The inventors have...
US20110160160 METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT  
The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective...