Patents and Patent Applications from University of Pittsburgh


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8691276 Extracellular matrix-derived gels and related methods  
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as...
8691185 Benzothiazole derivative compounds, compositions and uses  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
US20140094702 METHODS AND APPARATUSES FOR MEASURING TISSUE STIFFNESS CHANGES USING ULTRASOUND ELASTICITY IMAGING  
A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located...
US20140093452 Magnetic Resonance Imaging Cell Labeling Methods and Compositions  
The disclosure provides, in part, fluorocarbon imaging reagents and methods for image-guided treatment and/or diagnosis of a subject with a condition associated with an inflammatory response in an...
8685634 Neural scaffolds  
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater of vertebrate and can be processed...
8685385 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
US20140088300 Modified siRNA Molecules Incorporating 5-Fluoro-2'-Deoxyuridine Residues to Enhance Cytotoxicity  
A synthesized siRNA molecule having the sense strand with one or more uridine bases replaced by one or more respective nucleoside analogs, such as 5-fluoro-2′-deoxyuridine (FdU).
US20140088169 GENETIC CHANGES IN ATM AND ATR/CHEK1 AS PROGNOSTIC INDICATORS IN CANCER  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20140086982 ORAL THERAPY OF NECROTIZING ENTEROCOLITIS  
The present invention relates to methods of treating or reducing the risk of necrotizing enterocolitis (NEC) in an infant comprising orally administering an effective amount of a CpG-ODN. It is...
US20140081054 CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY  
The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high...
8676296 Echo-specific K-space reordering approach to compatible dual-echo arteriovenography  
A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo-specific K-space ordering scheme...
8674306 Gas sensing system employing raman scattering  
A gas detection system includes a light detector, a pump laser with spectral emission between UV and IR wavelengths and structured to generate a laser beam, a hollow waveguide structured to...
8673295 Thermoresponsive, biodegradable, elastomeric material and uses therefor  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers...
US20140073560 CITROBACTER FREUNDII ANTIBACTERIAL AGENTS AND THEIR USE  
Provided herein are methods for treating planktonic bacteria or a biofilm. The methods include contacting the planktonic bacteria or biofilm with an effective amount of an isolated Citrobacter...
US20140066332 METHODS FOR THE DIAGNOSIS OF FETAL DISEASE  
Methods are provided for detecting an aneuploidy in a fetus. These methods can be used to detect trisomy 13, 8 or 21, amongst other aneupoloidies. In some embodiments, the methods include...
US20140065672 SEPARATOME-BASED PROTEIN EXPRESSION AND PURIFICATION PLATFORM  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
US20140065016 PARACORPOREAL RESPIRATORY ASSIST LUNG  
A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is...
US20140062212 Wireless Energy Transfer System  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a...
US20140058032 MODIFICATION OF SURFACES WITH POLYMERS  
A polymer formed by controlled radical polymerization includes groups that can be modified after controlled radical polymerization to form a radical. The polymer can be the reaction product of a...
US20140057832 USE OF RELAXIN TO INCREASE ARTERIAL COMPLIANCE  
The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present...
US20140057315 ANTIGEN PRESENTING CELL ASSAY  
Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first...
8658379 Follistatin-like protein-1 as a biomarker for sepsis  
The present invention relates to methods and kits for diagnosing systemic inflammatory response syndrome or sepsis using levels of FSTL-1.
8658062 Nanoscale silicon-based compositions and methods of preparation  
The present invention is related to nano-particle compositions, methods of their preparation and applications thereof. The nano-particle compositions include silicon-containing nano-particles, a...
8651782 Wheeled mobility device containment systems and occupant retention systems and methods of containing wheeled mobility devices and retaining occupants thereof  
A system to contain a wheeled mobility device in a vehicle, includes: a rearward opening to allow access by the wheeled mobility device by moving the wheeled mobility device forward relative to...
US20140047569 Methods of Treating Disorders Associated with Protein Aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
US20140046208 COMPRESSIVE SAMPLING OF PHYSIOLOGICAL SIGNALS USING TIME-FREQUENCY DICTIONARIES BASED ON MODULATED DISCRETE PROLATE SPHEROIDAL SEQUENCES  
A method of sampling and reconstructing an original physiological signal obtained from a subject includes acquiring a number of samples of the original physiological signal, and generating a...
US20140045821 PROTEIN KINASE D INHIBITORS  
Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription,...
US20140045678 NON-NOBLE METAL BASED ELECTRO-CATALYST COMPOSITIONS FOR PROTON EXCHANGE MEMBRANE BASED WATER ELECTROLYSIS AND METHODS OF MAKING  
The invention provides electro-catalyst compositions for an anode electrode of a proton exchange membrane-based water electrolysis system. The compositions include a noble metal component selected...
8647666 Administration of an adsorbent polymer for treatment of systemic inflammation  
The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene...
US20140037581 METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA  
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a...
US20140037542 NOVEL THERANOSTIC PLATFORM FOR TARGETED CANCER THERAPY AND DRUG DELIVERY MONITORING  
A compound that includes a quaterrylene dye moiety as core, and a dendrimeric shell. For example, the compound may comprise at least four dendronized polyamides covalently attached to a...
US20140030694 OXYGEN DEPLETION DEVICES AND METHODS FOR REMOVING OXYGEN FROM RED BLOOD CELLS  
An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed...
8637556 Linked Myc-max small molecule inhibitors  
Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of...
US20140025623 POSTERIOR PROBABILITY OF DIAGNOSIS INDEX  
The likelihood of a disorder can be determined using a variety of techniques. One or more exhibited symptoms may be obtained for a patient. The likelihood that each symptom will be exhibited for...
8632983 Biomarkers for pancreatic cancer and diagnostic methods  
Methods and related kits for differentiating pancreatic cancer from a benign pancreatic disease. The method includes assaying a patient biological sample for a total level of CA 19-9 antigen and...
US20140018317 TARGETED NITROXIDE AGENTS  
A compound having a structure of:
US20140017309 ENTERAL ADMINISTRATION OF SORBENT POLYMER FOR TREATMENT AND PROPHYLAXIS OF INFLAMMATION  
The invention provides a method of ameliorating inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl...
8630810 Modeling wound healing  
Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue...
8628512 Emergency preservation and resuscitation methods  
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods...
US20140010811 ANTIBODIES TO ENDOPLASMIN AND THEIR USE  
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies,...
US20140010801 Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function  
This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or...
US20140005470 Graft Devices and Methods of Use  
A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a...
US20140005386 p53-Mdm2 ANTAGONISTS  
Novel p53-Mdm2 antogonists that conform to Formula I or to Formula II: where the prescribed substituent groups are defined, are useful in treating or preventing cancer. In particular, the...
US20140004161 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium...
US20140004124 MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA  
It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanoma associated antigen, is overexpressed on basal breast carcinoma cells (BBC),...
US20140001761 ADAPTIVE HYDROKINETIC ENERGY HARVESTING  
An energy harvester for producing useable energy from fluid motion of a fluid medium, the energy harvester comprising a support structure affixed directly or indirectly to a foundation or...
8617421 Lanthanide metal-organic frameworks and uses thereof  
Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new...
US20130345555 Sensor guided catheter navigation system  
A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a...
US20130345154 Gap Junction-Enhancing Agents for Treatment of Necrotizing Enterocolitis and Inflammatory Bowel Disease  
The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis (“NEC”) or inflammatory bowel disease (“IBD”) comprising administering,...
US20130344039 TH1-ASSOCIATED MICRORNAS AND THEIR USE FOR TUMOR IMMUNOTHERAPY  
Described herein is the identification of miRNAs (miRs) that are up-regulated in Th1 cells compared to Th2 cells (referred to herein as Th1-associated miRs). In particular, the miR-17-92 gene...