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US20040110283 |
Induction of tumor and viral immunity using antigen presenting cell co-culture products and fusion products
Formulations comprising combinations of APCs and tumor cells and APCs and virally infected cells are disclosed. These formulations generally comprise hybridoma of at least one antigen presenting...
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6744727 |
Apparatus and method for spare capacity allocation
A method is given for deriving a backup path routing spare capacity template that is feasible, scalable, adaptive, much faster, and near global optimal in redundancy reduction. The method includes...
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6743917 |
Camptothecin analogs and methods of preparation thereof
A compound and a method of synthesizing a compound having the following general formula (1): wherein R1 and R2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl...
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6743587 |
ACE genotype which correlates with improved success in sodium excretion in hypertensives with exercise
A method of increasing sodium excretion levels in a hypertensive subject by identifying a subject having an II genotype for an angiotensin converting enzyme gene, and engaging the subject in...
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6737270 |
Long-term three dimensional tissue culture system
A method is provided for long term culture of proliferating hepatocytes that retain hepatic function to produce a hepatic cell culture. Hepatocytes and nonparenchymal cells are co-cultured ex vivo...
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6734880 |
User interface for a medical informatics systems
A user interface for a medical informatics system, which permits a physician to work with digitized medical images in a manner that the physician is accustomed to working with traditional analog...
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6734318 |
Fluorous triphase and other multiphase systems
A method of reacting a first compound to produce a second compound includes the step of contacting a first non-fluorous phase including the first compound with a first fluorous phase at a first...
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6727390 |
Fluorous phosphines and phosphine oxides
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with or tagging the compound with at least one of a second compound having the formula: wherein R...
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6727078 |
EIAV p26 deletion vaccine and diagnostic
Disclosed herein is a vaccine which provides immunity to mammals from infection and/or disease caused by a lentivirus, such as equine infectious anemia virus, human immunodeficiency virus (HIV),...
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6723853 |
Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
A method of synthesizing a compound having the formula: from a compound having the formula: wherein R1 is hydrogen, fluorine, chlorine or SiR5R6R7, wherein R5, R6, and R7 are independently the same...
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6723702 |
Use of relaxin treat diseases related to vasoconstriction
The invention related to methods of treating disease related to vasoconstriction that is a major factor in hypertensive vascular diseases and vasodilation, generally comprising administering to an...
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6723284 |
Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the...
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6712990 |
Magnetorheological fluids and related method of preparation
Magnetorheological (MR) fluids, dispersions of magnetically soft particles in fluids (gases, liquids, or semi-solids such as greases), are disclosed. The present invention uses the initial steps of...
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6711297 |
Methods and apparatus for dynamic transfer of image data
A dynamic transfer syntax efficiently transfers data, including large data images, from a server to at least one client. Source data is transformed into a hierarchical representation. The...
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6706839 |
Chemical partitioning agents and methods of using same
The present invention is directed to partitioning agents and methods of using same to effectuate separation of a reactant, intermediate product, and/or final product from a reaction mixture while...
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US20040043488 |
Adeno-associated viral gene-transfer vector system
The present invention provides a recombinant HSV incorporating an adeno-associated virus (AAV) gene comprising a promoter and a polynucleotide sequence encoding a rep polypeptide. Preferably, the...
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6693123 |
Inhibitors of protein isoprenyl transferases
Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h)...
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US20040030335 |
Device and method of use for functional isolation of animal or human tissues
A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the...
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6686438 |
Carbon dioxide-philic compounds and methods of synthesis thereof
A method of synthesizing a CO2-philic analog of a CO2-phobic compound, includes the step of: reacting the CO2-phobic compound with a CO2-philic compound selected from the group of a polyether...
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6685946 |
Cold-adapted equine influenza viruses
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza...
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US20040018973 |
Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and...
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6673937 |
Syntheses and methods of use of new antimitotic agents
Oxidative cyclization of bis-naphthyl ethers allows concise total syntheses of palmarumycin CP1 and deoxypreussomerin A in 8-9 steps and 15-35% overall yield from 5-hydroxy-8-methoxy-1-tetralone. A...
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6673539 |
Fluorous tagging compounds and methods of use thereof
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group and m is 0,...
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6670180 |
Cell culture media for mammalian cells
A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.
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6670176 |
Adeno-associated virus capable of expressing factor IX protein and cells comprising the same
The subject invention concerns a recombinant adeno-associated virus vector characterized as being capable of delivering and expressing at least one mammalian gene into a genome of a mammalian host...
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US20030236391 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
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US20030228640 |
Nuclear matrix proteins, polynucleotide sequences encoding them, and their use
A novel prostate cancer marker is described that is found in cancerous and normal cells of the prostate in individuals that have prostate cancer but is not found in the prostate of individuals...
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6656446 |
Synthesis of hydrogen peroxide
A method for synthesizing hydrogen peroxide comprises the step of: mixing an analog of a secondary alcohol that is soluble with carbon dioxide with a free radical initiator and oxygen in carbon...
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US20030220283 |
Gene transfer for treating a connective tissue of a mammalian host
Methods for treating a connective tissue disorder by introducing at least one gene encoding a product into at least one target cell of a mammalian host for use in treating the mammalian host are...
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US20030216359 |
Combination chemotherapy
This invention relates to combination chemotherapy, particularly involving vitamin D or a derivative thereof. In one aspect, the invention provides a method of killing a cell by first administering...
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6649169 |
Cold-adapted equine influenza viruses
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza...
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US20030206888 |
Herpes simplex virus strains
The present invention provides an HSV having a genome with a mutation of a TAATGARAT sequence such that, in the presence of a ICP4 gene product, a native immediate early gene is expressed from the...
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6643591 |
Use of computational and experimental data to model organic compound reactivity in cytochrome P450 mediated reactions and to optimize the design of pharmaceuticals
The present invention is directed to the use of computational and other experimental data in the design of new pharmaceuticals, and in predicting the metabolism and toxicological profiles thereof....
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US20030203427 |
Alpha1-3 galactosyltransferase gene and promoter
The present invention provides a recombinant expression cassette comprising an α1-3 galactosyltransferase promoter operably linked to a polynucleotide for expression. The invention also provides a ...
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6638749 |
Carbon dioxide soluble surfactant having two fluoroether CO2-philic tail groups and a head group
There is provided a process for the extraction of water soluble biomaterials such as enzymes or proteins into carbon dioxide utilizing certain carbon dioxide-soluble surfactants. Also provided are...
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US20030199074 |
Cold-adapted equine influenza viruses
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza...
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6633710 |
Opto-electronic multi-chip modules using imaging fiber bundles
Multipath structures formed from coherent fiber bundle structures for interconnecting a number of opto-electronic devices in a compact space. The coherent fiber bundle structures are formed from...
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6628378 |
Methods and apparatus for aligning rolls
Apparatus and methods for aligning rolls, wherein a first structure, for being associated with a first roll, and a second structure, for being associated with a second roll are provided. A laser is...
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6626905 |
Posterior oblique lumbar arthrodesis
Instruments and methods for spinal stabilization are disclosed. In preferred embodiments, the invention provides greater stabilization of vertebral bodies through methods including combinations of...
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US20030176403 |
Combination chemotherapy
The invention provides a method of treating a patient with vitamin-D or a derivative thereof involving the adjunctive administration of zoledronate.
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6620937 |
Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel...
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US20030170754 |
Nuclear matrix proteins, polynucleotide sequences encoding them, and their uses
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue, particularly prostate tissue, are provided. These NMPs are useful markers in diagnosing and monitoring the...
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6617432 |
Nuclear matrix proteins polynucleotide sequences encoding them and their use
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue, particularly prostate tissue, are provided. These NMPs are useful markers in diagnosing and monitoring the...
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6615074 |
Apparatus for energizing a remote station and related method
Apparatus for remote interaction with an object of interest includes a remote station for obtaining information from the object of interest, a base station for transmitting energy in space to and...
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6610321 |
Emulsion formulations for hydrophilic active agents
This invention includes emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one...
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6605602 |
Method of treating BK virus nephropathy
Provided are oligonucleotides for the quantitation of BK virus (BKV) viral loads in a sample and methods for the diagnosis and management of BKV-associated nephropathy using PCR or QPCR methods. In...
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US20030143647 |
Anticancer vaccine and diagnostic methods and reagents
The invention provides a method of priming T cells against tumor antigens comprising by obtaining naïve CD4+ or CD8+ T cells from at least one healthy individual, obtaining at least one protein or ...
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US20030142934 |
Endoscopic imaging system
A system and method for an endoscopic optical coherence tomography (OCT) system based on a CMOS-MEMS mirror to facilitate lateral light scanning. The laser scanning scope, adapted to the instrument...
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6599247 |
System and method for location-merging of real-time tomographic slice images with human vision
A device for combining tomographic images with human vision using a half-silvered mirror to merge the visual outer surface of an object (or a robotic mock effector) with a simultaneous reflection...
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6596884 |
Synthesis of hydrogen peroxide
A method for synthesizing hydrogen peroxide comprises the steps of: synthesizing an analog of anthraquinone that is miscible or soluble in carbon dioxide; reacting the analog of anthraquinone with...
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