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Patents and Patent Applications from University of Pittsburgh


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US20110123286 WHEELED MOBILITY DEVICE CONTAINMENT SYSTEMS AND OCCUPANT RETENTION SYSTEMS AND METHODS OF CONTAINING WHEELED MOBILITY DEVICES AND RETAINING OCCUPANTS THEREOF  
A system to contain a wheeled mobility device in a vehicle, includes: a rearward opening to allow access by the wheeled mobility device by moving the wheeled mobility device forward relative to the...
US20110118214 LIGANDS SPECIFIC FOR CANNABINOID RECEPTOR SUBTYPE 2  
A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or...
US20110111656 DURABLE SUPERHYDROPHOBIC COATINGS  
Durable superhydrophobic coating composition having a composition ranging from about 10 to about 80 w.t. % of an acrylic polymer resin, from about 5 to about 40 w.t. % of a polysiloxane oil, from...
US20110111437 Biomarkers For Prognosis of Pulmonary Diseases  
The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic...
US20110110941 Wortmannin Analogs and Methods of Using Same in Combination with Chemotherapeutic Agents  
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the...
US20110104739 BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the...
US20110104694 COMPOSITIONS AND METHODS FOR DETECTING CANCER  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
US20110104213 Porous Biomolecule-Containing Metal-Organic Frameworks  
The present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic...
US20110103312 Methods and Apparatus for Switching A Transponder To an Active State, and Asset Management Systems Employing Same  
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
US20110101788 Wireless Energy Transfer System  
A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load....
US20110098651 DISSOLVABLE MICRONEEDLE ARRAYS FOR TRANSDERMAL DELIVERY TO HUMAN SKIN  
A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the...
7933861 Process data warehouse  
Systems and/or methods are presented that can efficiently analyze and summarize large collections of data. A summarization component can employ mapping rules to map received data into specified...
US20110091957 PROTEIN-POLYMER CONJUGATES AND SYNTHESIS THEREOF  
A method of synthesizing a protein-polymer conjugate includes the steps: covalently attaching at least one controlled radical polymerization initiator to a protein to form a protein-initiator...
US20110091908 EARLY PROSTATE CANCER ANTIGEN-2: A NOVEL SERUM SPECIFIC MARKER FOR PROSTATE CANCER DETECTION  
Early Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall...
7927544 Paracorporeal respiratory assist lung  
A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is...
US20110086909 SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
US20110086894 BIOMARKERS FOR THE DIAGNOSIS OF ALS  
Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative...
7920736 Methods and systems for imaging cells  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
US20110064703 BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate,...
7907769 Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation  
The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell...
7906110 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
The invention is directed to preparation of stem cell and physiologically acceptable matrix compositions. Compared with previous tissue engineering materials, the stem cell-matrix compositions of...
US20110060461 Cortical Control of a Prosthetic Device  
A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and...
7902272 Highly diffracting, color shifting, polymerized crystalline colloidal arrays of highly charged polymer spheres, paints and coatings and processes for making the same  
One aspect of the present disclosure is directed towards a new film forming paint that Bragg diffracts light in the visible and NIR spectral regions. The paint may be comprised of highly charged...
7897569 Use of HMGB fragments as anti-inflammatory agents  
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The...
7897326 Peroxisome-proliferator activated receptor-alpha agonists for organ preservation  
Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) ...
US20110045507 FSTL-1 AS A BIOMAKER OF INFLAMMATION  
The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1...
US20110039792 Selective Targeting Agents for Mitochondria  
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the...
US20110039277 Methods of Labeling Proteins  
Methods are provided for labeling specific oxidized proteins. Methods also are provided for determining the oxidation state of a cell. Such methods are useful as diagnostic, therapeutic and...
7887792 Muscle-derived cells (MDCs) for treating muscle- or bone-related injury or dysfunction  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
7884085 Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
7882909 Personal vehicle  
A personal vehicle comprises a frame with a seat, two large, non-drive wheels connected by an axle at one end of the frame, an elongated swing arm attached to the axle, a pair of caster wheels...
US20110028961 EMERGENCY PRESERVATION AND RESUSCITATION METHODS  
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods...
7878978 Use of relaxin to increase arterial compliance  
The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present...
7876225 Methods and apparatus for switching a transponder to an active state, and asset management systems employing same  
A transponder that may be used as an RFID tag includes a passive circuit to eliminate the need for an “always on” active RF receiving element to anticipate a wake-up signal for the balance of the...
US20110012728 Sensor and System to Detect Bridge Scour  
A system for detecting scour associated with a structure having a part thereof extending into a bed of material located under a body of water is provided. The system comprises a sensor unit buried...
7872027 Low molecular weight Myc-max inhibitors  
Compounds and compositions for interfering with the association of Myc and Max are described herein. These compounds and compositions are useful in methods inhibiting growth or proliferation of a...
US20110009899 TENSION TRANSDUCING FORCEPS  
A forceps device is provided for performing a surgical procedure. The device comprises a closeable jaw comprising jaw members having one or more force sensors deployed in a manner to measure force...
7867752 Method and apparatus for holding cells  
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown,...
US20110002899 Lymph Nodes as a Site for Regeneration  
Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
US20100331767 INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS  
A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft...
7858657 Wortmannin analogs and methods of using same in combination with chemotherapeutic agents  
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the...
7858071 Biomarkers for amyotrophic lateral sclerosis  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the...
US20100324112 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20100323029 FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE  
Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild...
US20100322909 TH1-ASSOCIATED MICRORNAS AND THEIR USE FOR TUMOR IMMUNOTHERAPY  
Described herein is the identification of miRNAs (miRs) that are up-regulated in Th1 cells compared to Th2 cells (referred to herein as Th1-associated miRs). In particular, the miR-17-92 gene...
7854920 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
US20100314575 ANTI-ICING SUPERHYDROPHOBIC COATINGS  
Superhydrophobic coating compositions are provided. The compositions comprise nanoparticles between 5-100 nm in size and a polymeric binder. The compositions are effective in preventing ice...
7851144 Compositions and methods for detecting cancer  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
US20100298352 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS  
A method of inhibiting a carcinoma in a subject, comprising administering to the subject at least one therapeutic agent that selectively targets carcinoma stem cells. Illustrative carcinoma stem...
US20100297158 ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS  
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the...