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Patents and Patent Applications from University of Pittsburgh


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US20110002899 Lymph Nodes as a Site for Regeneration  
Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
US20100331767 INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS  
A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft...
7858657 Wortmannin analogs and methods of using same in combination with chemotherapeutic agents  
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the...
7858071 Biomarkers for amyotrophic lateral sclerosis  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the...
US20100324112 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
US20100323029 FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE  
Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild...
US20100322909 TH1-ASSOCIATED MICRORNAS AND THEIR USE FOR TUMOR IMMUNOTHERAPY  
Described herein is the identification of miRNAs (miRs) that are up-regulated in Th1 cells compared to Th2 cells (referred to herein as Th1-associated miRs). In particular, the miR-17-92 gene...
7854920 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition  
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising...
US20100314575 ANTI-ICING SUPERHYDROPHOBIC COATINGS  
Superhydrophobic coating compositions are provided. The compositions comprise nanoparticles between 5-100 nm in size and a polymeric binder. The compositions are effective in preventing ice...
7851144 Compositions and methods for detecting cancer  
The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and...
US20100298352 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS  
A method of inhibiting a carcinoma in a subject, comprising administering to the subject at least one therapeutic agent that selectively targets carcinoma stem cells. Illustrative carcinoma stem...
US20100297158 ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS  
The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the...
7838251 Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof  
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and...
US20100292149 Modulation of the Neuroendocrine System as a Therapy for Motor Neuron Disease  
The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a...
US20100292072 REGENERABLE SOLID IMINE SORBENTS  
Two new classes of amine-based sorbents are disclosed. The first class comprises new polymer-immobilized tertiary amine sorbents; the second class new polymer-bound amine sorbents. Both classes are...
US20100285489 METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
US20100282245 Detection of nitric oxide  
A system for the detection of nitric oxide in a gas sample includes a converter for oxidation of nitric oxide to nitrogen dioxide, a nitrogen dioxide sensor including nanostructures and a filtering...
7829536 Method of treating lymphedema comprising administering VEGF-D  
The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.
7829097 Use of HMGB1 for protection against ischemia reperfusion injury  
Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1...
US20100279969 AZIDO PURINE NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The...
US20100276975 ANGLE ADJUSTABLE BACKREST MOUNTING  
Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of...
7825807 Transponder networks and transponder systems employing a touch probe reader device  
Transponder networks and transponder systems are provided which help to overcome the issues presented to transponders systems by FCC power limitations. One embodiment provides a transponder network...
7825267 Synthesis of FR901464 and analogs with antitumor activity  
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are...
US20100260855 DELIVERY OF AS-OLIGONUCLEOTIDE MICROSPHERES TO INDUCE DENDRITIC CELL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE TYPE 1 DIABETES  
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense...
US20100260406 METHODS AND SYSTEMS FOR IMAGING CELLS  
The invention generally provides methods and systems for determining characteristics of cellular structures. The methods include non-invasive, non-perturbing, automatable, and quantitative methods...
US20100258116 DEVICES, SYSTEMS AND METHODS FOR REDUCING THE CONCENTRATION OF A CHEMICAL ENTITY IN FLUIDS  
A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized...
US20100256943 CONFIGURATION OF INITIAL CONTROL PARAMETERS IN PHOTODETECTORS FOR MULTI-COLOR FLOW CYTOMETRY  
System(s) and method(s) for initial configuration of photodectors in a multi-color flow cytometer to mitigate spectral compensation. Configuration is iterative and automated, and optimizes...
US20100255525 Fluorescent ozone sensor  
A selective, fluorescent “turn-on” probe and method for the detection of ozone in biological and atmospheric samples, wherein the method of detecting ozone in a sample comprises the steps of (1)...
7806589 Bi-plane X-ray imaging system  
A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of...
US20100234827 METHOD OF TREATING HEART FAILURE  
The present invention includes methods, systems, uses, and means for the delivery of one or more anti-fibrotic agents into the pericardial space for the treatment and prevention of heart failure (HF).
US20100233752 METHOD FOR DIAGNOSIS AND MONITORING OF DISEASE ACTIVITY AND RESPONSE TO TREATMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND OTHER AUTOIMMUNE DISEASES  
The present invention provides methods of diagnosing and monitoring systemic lupus erythematosus and drug-induced lupus erythematosus by measuring cell-based complement activation products in a...
US20100233138 Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following...
US20100231218 Method for Producing A Magnetic Resonance Image of an Object Having a Short T2 Relaxation Time  
A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded magnetic...
US20100227393 LIVER STEM CELLS: ISOLATION OF HEPATIC PROGENITOR CELLS FROM THE HUMAN GALL BLADDER  
Methods of preparing multipotent cell populations from gallbladder are provided. Also provided are enriched multipotent cell populations from gallbladder and methods of differentiating the...
US20100226895 NEURAL SCAFFOLDS  
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater of vertebrate and can be processed to...
7792392 Fiber optic gas sensor  
A gas sensor includes an in-fiber resonant wavelength device provided in a fiber core at a first location. The fiber propagates a sensing light and a power light. A layer of a material is attached...
7791557 Multiple antenna energy harvesting  
Energy harvesting circuits and associated methods are provided that employ multiple antennas to optimize the amount of energy that is harvested while at the same time making efficient use of tag...
7790037 Separation of compounds using tagging moieties including varying numbers of repeat units  
A method of separating compounds, includes: a. tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; b. tagging at least a second organic...
US20100222882 JOINT BIOSCAFFOLDS  
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of...
US20100216884 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES  
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its m...
US20100216149 SUSCEPTIBILITY GENES FOR AGE-RELATED MACULOPATHY (ARM) ON CHROMOSOME 10q26  
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of...
US20100215623 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF  
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction...
7781164 Method for diagnosing renal diseases or predispositions  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
7776908 Wortmannin analogs and methods of using same  
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well, as tumor formation in a subject are described herein.
US20100191174 HAND-HELD ELECTRICAL STIMULATION DEVICE  
Apparatuses and methods for the safe and efficient electrical stimulation of tissue. The apparatuses of the present invention are preferably hand-held and are capable of providing electrical...
US20100190239 DEGRADATION OF NANOMATERIALS  
A method of degrading carbon nanomaterials includes mixing the carbon nanomaterials with a composition comprising a peroxide substrate and at least one catalyst selected from the group of an enzyme...
7763097 Devices, systems and methods for reducing the concentration of a chemical entity in fluids  
A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized...
US20100184953 STABLE LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
US20100173971 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer  
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation...
7750632 Method for producing a magnetic resonance image of an object having a short T2 relaxation time  
A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded magnetic...