Patents and Patent Applications from University of Pittsburgh


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8827943 Catheter  
In one aspect, the invention provides a device comprising a catheter. In another aspect, the invention provides a method of removing an agent from blood.
US20140249595 Methods and Systems for Achieving a Physiological Response by Pudendal Nerve Stimulation and Blockade  
Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The...
US20140249427 DEPTH-SELECTIVE FIBER-OPTIC PROBE  
Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can...
US20140249209 METHODS FOR THE TREATMENT AND PREVENTION OF LIVER DISEASE  
The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an...
US20140248288 BIODEGRADABLE METAL ALLOYS  
The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components,...
US20140248232 BIODEGRADABLE, NON-THROMBOGENIC ELASTOMERIC POLYURETHANES  
A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the...
8822571 High refractive index crystalline colloidal arrays materials and a process for making the same  
Disclosed are a new composite material and a process for synthesizing highly charged, highly monodisperse, core-shell particles with high refractive index cores, as well as stable, long lasting...
8822541 Use of targeted nitroxide agents in mitigating or treating radiation injury  
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached...
US20140243911 BIODEGRADABLE, MAGNESIUM-CONTAINING BONE SCREWS, METHODS FOR THEIR PREPARATION AND MEDICAL APPLICATIONS THEREFOR  
The invention relates to a biodegradable, magnesium-containing bone screw for implanting into a patient body for use in medical applications, such as, orthopedic, craniofacial and cardiovascular...
US20140243215 METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
8818557 Cortical control of a prosthetic device  
A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and...
8815946 Inhibition of proliferation and fibrotic response of activated corneal stromal cells  
Provided herein are methods of preventing a fibrotic response and/or scarring in a wound, comprising administering to a subject a composition comprising an amount of an amide or ester of an...
8815829 3′-azido purine nucleotide prodrugs for treatment of viral infections  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The...
8815602 Urinary biomarkers for predicting long-term dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
8815071 Manipulation, detection, and assay of small scale biological particles  
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. A particle manipulation device contains a plurality of electrodes formed...
8814787 Articulating laryngoscope  
Articulating laryngoscope to aid in the intubation of patients by providing illumination of the oral cavity and trachea during the process having, for example, ‘fingers’ with fiber optic lights at...
US20140236005 CONTRAST ASSISTED INTRAVASCULAR ULTRASOUND IMAGING  
A method of imaging a blood vessel includes delivering a bubble-based contrast agent within the vessel and positioning at least one ultrasound device in the vicinity of the bubble-based contrast...
US20140234324 METHODS FOR TREATING A TUMOR USING AN ANTIBODY THAT SPECIFICALLY BINDS GRP94  
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer...
8809617 Automated high-content live animal drug screening using C. elegans  
The present invention relates to methods and compositions for high content drug screening in C. elegans which may be used to identify compounds that treat disorders associated with protein...
US20140228918 ACTIVELY AND SELECTIVELY COOLED CUSHIONING SURFACE  
A cushioning surface for cooling tissue that reaches a predefined level of immersion into the cushioning surface, comprising: a segmented fluid cushion comprising a plurality of cells...
US20140228741 INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS  
A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft...
8805510 Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade  
Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The...
US20140220590 METHODS OF USING BENZOTHIAZOLE DERIVATIVE COMPOUNDS AND COMPOSITIONS  
This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid...
US20140220061 YEAST EXPRESSION OF FLAVIVIRUS VIRUS-LIKE PARTICLES AND USE THEREOF  
Described herein is a method for the production of flavivirus virus-like particles (VLPs) in a yeast system. In some cases, flavivirus structural proteins are expressed in a Pichia pastoris strain...
US20140219963 Extracellular Matrix-Derived Gels and Related Methods  
Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as...
US20140219486 SYSTEM AND METHOD FOR ENHANCING THE BINAURAL REPRESENTATION FOR HEARING-IMPAIRED SUBJECTS  
A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated...
US20140213891 APPARATUS AND METHOD FOR IMPLANTATION OF DEVICES INTO SOFT TISSUE  
Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position...
US20140213517 Thermoresponsive, Biodegradable, Elastomeric Material and Uses Therefor  
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers...
8790680 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
US20140204364 METHODS FOR MAKING AND COMPOSITIONS OF TWO DIMENSIONAL PARTICLE ARRAYS  
A method of preparation of a 2-D array of particles comprising: mixing the particles and a first liquid, the first liquid having the properties of being soluble in water and reducing surface...
US20140200824 K-PARTITE GRAPH BASED FORMALISM FOR CHARACTERIZATION OF COMPLEX PHENOTYPES IN CLINICAL DATA ANALYSES AND DISEASE OUTCOME PROGNOSIS  
Systems and methods are disclosed that can analyze relationships between parameters in data matrices (e.g., collections of individual profiles). A graph topology can be defined on a data matrix...
US20140194365 USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS  
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and...
8772541 Cannabinoid receptor 2 (CB2) inverse agonists and therapeutic potential for multiple myeloma and osteoporosis bone diseases  
Cannabionid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are independently H, alkyl, or alkenyl; R3...
8771728 Stable lipid-comprising drug delivery complexes and methods for their production  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
8771687 Methods for treating a tumor using an antibody that specifically binds GRP94  
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer...
US20140188499 HUMAN ACTION MONITOR  
Systems and corresponding methodologies that enable continuous, real-time or near real-time monitoring of joint activity of patients who are undergoing physical therapy is provided. A joint's...
US20140187901 ELECTRODE SYSTEMS, DEVICES AND METHODS  
An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q′ ratio of at least 5...
8765120 Muscle-derived cells (MDCS) for augmenting or bulking urethral sphincter-muscle tissue  
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
US20140179595 APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE  
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as...
US20140178451 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE  
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by...
8759097 Inhibition of dynamin related protein 1 to promote cell death  
The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i)...
8759016 Multiparametric method for assessing immune system status  
The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a...
8759001 Method for diagnosing renal diseases or predispositions  
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a...
US20140170121 Neural Scaffolds  
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater of vertebrate and can be processed...
8754094 Methods for heat shock protein dependent cancer treatment  
The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective...
US20140163111 POROUS BIOMOLECULE-CONTAINING METAL-ORGANIC FRAMEWORKS  
The invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic frameworks...
US20140161877 PEDERIN AND PSYMBERIN AGENTS  
Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be...
US20140161726 Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents  
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such...
8748950 On-demand nanoelectronics platform  
A reconfigurable device includes a first insulating layer, a second insulating layer, and a nanoscale quasi one- or zero-dimensional electron gas region disposed at an interface between the first...
8748369 Use of targeted nitroxide agents in bone healing  
Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting...