Patents and Patent Applications from University of Pennsylvania


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US20180044623 ARTIFICIAL PLACENTA AND METHODS OF PREPARATION  
The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e.,...
US20180044424 CAR-EXPRESSING CELLS AGAINST MULTIPLE TUMOR ANTIGENS AND USES THEREOF  
The invention provides compositions and methods for treating cancer by using immune effector cells (e.g., T cells, NK cells) engineered to conditionally express an agent which enhances the immune...
US20180044423 TREATMENT OF CANCER USING A CD33 CHIMERIC ANTIGEN RECEPTOR  
The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors...
9893264 Method for forming a suspended lithium-based membrane semiconductor structure  
In one aspect, a microelectronic device comprises: a suspended lithium-based thin film; and one or more electrodes disposed on the suspended lithium-based thin film, wherein the one or more...
9890365 Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency  
Non-viral delivery systems comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine...
9889082 Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH  
This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a...
US20180039402 USER INTERFACE INPUT METHOD AND SYSTEM FOR HANDHELD AND MOBILE DEVICES  
Methods, systems, and computer readable media for receiving user input. According to one example method for receiving user input, the method includes identifying gestures from directional...
US20180037625 USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an...
US20180036385 AAV-MEDIATED GENE THERAPY FOR RPGR X-LINKED RETINAL DEGENERATION  
Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with retinitis pigmentosa and x-linked retinitis pigmentosa in a...
9885055 Chloroplasts engineered to express pharmaceutical proteins  
Vaccines for conferring immunity in mammals to infective pathogens are provided, as well as vectors and methods for plastid transformation of plants to produce protective antigens and vaccines for...
9884832 Inhibitors targeting drug-resistant influenza A  
Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via...
9884106 Influenza nucleic acid molecules and vaccines made therefrom  
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also...
9884071 Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer  
A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described....
9884031 Use of HDAC inhibitors for treatment of cardiac rhythm disorders  
The present invention provides methods of ameliorating or reducing the extent of cardiac arrhythmia disorders, by administering an inhibitor of histone deacetylase enzyme (HDAC).
US20180030502 Regulation of Autophagy and Cell Survival  
Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to suc an individual a combination of...
US20180030479 METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY  
Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.
US20180030110 Fully-human T-cell receptor specific for the 369-377 epitope derived from the Her2/Neu (ERBB2) receptor protein.  
The present invention relates to compositions and methods for treating HER2/Neu (ERBB2) expressing cancer cells. In some embodiments, the invention includes an isolated T cell receptor (TCR)...
US20180028672 Protease Triggered Release Of Molecules From Hydrogels  
The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a...
US20180028640 PROTEINS COMPRISING MRSA PBP2A AND FRAGMENTS THEREOF, NUCLEIC ACIDS ENCODING THE SAME, AND COMPOSITIONS AND THEIR USE TO PREVENT AND TREAT MRSA INFECTIONS  
Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are...
US20180028625 ADMINISTRATION OF PLANT EXPRESSED ORAL TOLERANCE AGENTS  
Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is other complicated by pathogenic antibody responses, including antibodies that neutralize the...
US20180028417 IRON OXIDE NANOPARTICLES AND METHODS OF USE THEREOF  
The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm...
US20180024140 ATOMIC DESCRIPTION OF IMMUNE COMPLEX THAT CAUSES HEPARIN-INDUCED THROMBOCYTOPENIA  
The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is...
US20180022795 TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY  
The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR)...
US20180021579 METHOD AND APPARATUS FOR IMPROVING COGNITIVE PERFORMANCE  
A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes...
US20180016638 NOVEL METHODS FOR EARLY IDENTIFICATION OF BONE HEALING ABILITY IN INJURED PATIENTS  
The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be...
US20180016598 Simian Adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50, and Uses Thereof  
A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian...
US20180015161 Checkpoint Inhibitor and Vaccine Combinations and Use of Same For Immunotherapy  
Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering...
US20180015149 COLLAGEN III COMPOSITION AND USES  
The invention includes methods of suppressing cancer metastasis and local recurrence in a subject. In one aspect, the method comprises removing the tumor by surgery; and implanting a composition...
9868990 Compositions and methods for detecting and treating neurological conditions  
The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and...
9865465 Nanocrystal thin film fabrication methods and apparatus  
Nanocrystal thin film devices and methods for fabricating nanocrystal thin film devices are disclosed. The nanocrystal thin films are diffused with a dopant such as Indium, Potassium, Tin, etc. to...
9861622 Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects  
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to...
9861474 Cardiac repair prosthesis sets and methods  
Cardiac repair prostheses, sets, and methods for implanting in an aorta are disclosed. Cardiac repair prosthesis sets can include a radially expandable support supporting a unidirectional valve...
US20180002716 COMPOSITIONS AND METHODS THEREOF FOR DOWN-REGULATION OF GENES FOLLOWING ORAL DELIVERY OF AN RNAI MOLECULE BIOENCAPSULATED WITHIN PLANT CELLS  
Compositions and methods for down-regulating genes through oral administration of RNAi molecule encapsulated in plant cells are provided.
US20180002698 C-REL-SPECIFIC SIRNA AND ITS USE FOR PREVENTING AND TREATING AUTOIMMUNE PSORIASIS  
The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos....
US20180000928 Immunogenicity of an Optimized Synthetic Consensus DNA Vaccine for Porcine Epidemic Diarrhea Virus  
Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need...
9856275 Synthesis and use of fluorinated compounds  
The invention is directed to the preparation of fluorinated compounds and their use in organic synthesis. In particular, the invention is directed to methods of reacting compounds of structure...
9855357 Rapid surface disinfection method and apparatus  
A device for rapidly sanitizing a surface is described. The device has an enclosure having an opening adapted to insert a surface, and an interior; a liquid nitric oxide solution applicator; and...
US20170372137 SYSTEMS, DEVICES, AND METHODS FOR ROBOTIC REMOTE SENSING FOR PRECISION AGRICULTURE  
The present subject matter relates to systems, devices, and methods for data-driven precision agriculture through close-range remote sensing with a versatile imaging system. This imaging system...
US20170369777 MORPHOLOGICALLY AND SIZE UNIFORM MONODISPERSE PARTICLES AND THEIR SHAPE-DIRECTED SELF-ASSEMBLY  
Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their...
US20170369561 GLYPICAN-3-SPECIFIC ANTIBODY AND USES THEREOF  
The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of GPC3. The invention provides...
US20170368180 METHODS OF PROMOTING NERVOUS SYSTEM REGENERATION  
The invention includes a composition comprising an astrocyte comprising aligned and elongated astrocyte processes resulting from ex vivo machine-driven, physical stretching of the astrocyte...
9851425 Background-suppressed myelin water imaging  
A technique and associated imaging system is provided that selectively acquires the myelin water signal by utilizing a multiple inversion RF pulses to suppress a range of long T1 components...
9850469 Methods of stapling and unstapling peptides and proteins  
The present disclosure pertains to the field peptide stapling and/or macrocyclization, where a structural motif is used to improve the properties of amino acid sequences (e.g. protease resistance,...
9850292 Compositions which regulate the epithelial brush border Na+/H+ exchanger NHE3 and their methods of use in gastrointestinal disease  
A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3....
9850261 Silicon-based cross coupling agents and methods of their use  
Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
US20170365057 Semi-Automated Heart Valve Morphometry And Computational Stress Analysis From 3D Images  
A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets...
US20170362669 COMPOSITIONS, KITS, AND METHODS TO DETECT HIV VIRUS  
Provided herein include compositions comprising a primer having the nucleic acid sequence of ACeIN-F3_c, a primer having the nucleic acid sequence of ACeIN-B3_a, a primer having the nucleic acid...
US20170362295 USE OF ICOS-BASED CARS TO ENHANCE ANTITUMOR ACTIVITY AND CAR PERSISTENCE  
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen...
9846157 Compositions, methods and microfluidics device for telomerase based in vitro diagnostic assays for detecting circulating tumor cells (CTC)  
A repeatable method for detecting circulating tumor cells in vitro is provided. The method involves combining a test sample from a patient suspected of having circulating tumor cells, and a...
9845480 Transcriptome transfer produces cellular phenotype conversion  
The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a...