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US20120129810 |
COMBINATION ANTINEOPLASTIC THERAPY
The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.
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US20120129273 |
PHOTOLITHOGRAPHICALLY DEFINED CONTACTS TO CARBON NANOSTRUCTURES
Methods for the fabrication of nanostructures, including nanostructures comprised of carbon nanotubes, and the nanostructures, devices, and assemblies prepared by these methods, are described.
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US20120129261 |
Transcriptome Transfer Produces Cellular Phenotype Conversion
The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a...
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8183352 |
Attenuated vif DNA immunization cassettes for genetic vaccines
The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted...
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US20120122910 |
METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR
Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a...
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US20120122834 |
SMALL MOLECULE CD4 MIMETICS AND USES THEREOF
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
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US20120121640 |
OX40/TRAIL Fusion Proteins
Fusion proteins which act on the OX40/TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, and...
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8178660 |
Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same
Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid...
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US20120116221 |
METHODS AND SYSTEMS FOR IMAGE-GUIDED TREATMENT OF BLOOD VESSELS
Methods and systems of treating at least one blood vessel involves the application of therapy ultrasound to the blood vessel(s) using one or more dosing conditions. An image of the region of...
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US20120114676 |
METHODS OF TREATING CANCER WITH PHENFORMIN
Methods of using phenformin to treat certain types of cancers are described.
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US20120114615 |
HYDROLYTICALLY DEGRADABLE POLYSACCHARIDE HYDROGELS
Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such...
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8173786 |
Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins...
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8173335 |
Beam ablation lithography
Provided are beam ablation lithography methods capable of removing and manipulating material at the nanoscale. Also provided are nanoscale devices, nanogap field effect transistors, nano-wires,...
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US20120108559 |
RECEPTOR ACTIVATOR OF THE RANK RECEPTOR COMPLEX INHIBITOR
Methods and pharmaceutical compositions utilizing compounds of Formula II: for inhibiting osteoclastogenesis and the activity of osteoclasts in patients.
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US20120107593 |
HIGH YIELD PREPARATION OF MACROSCOPIC GRAPHENE OXIDE MEMBRANES
Disclosed are graphene oxide membrane materials of high surface area, which membranes suitably have a surface area of above about 200 μm and exhibit electrical conductivity in excess of about 200 ...
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8168769 |
HPV vaccines and methods for using the same
Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed, Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those...
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8165517 |
Methods for identifying inhibitors of vascular injury
The present invention provides, inter alia, inhibitors of cardiovascular diseases and disorders. The present invention also provides therapeutic methods for preventing and/or treating...
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8163726 |
Method of inhibiting choroidal neovascularization
The present invention relates to compositions and methods for inhibiting unwanted angiogenesis, particularly those of ocular tissues. The treatment, inhibition, and/or prevention of choroidal...
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US20120093913 |
Inhibition of SYK kinase expression
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).
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US20120093853 |
Simian Adenovirus Vectors and Methods of Use
A recombinant vector comprises a simian adenovirus capsid and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed....
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US20120093778 |
SIMIAN ADENOVIRUS NUCLEIC ACID AND AMINO ACID SEQUENCES, VECTORS CONTAINING SAME, AND METHODS OF USE
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also...
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US20120093717 |
MICROSPHERE/NANOFIBER COMPOSITES FOR DELIVERY OF DRUGS, GROWTH FACTORS, AND OTHER AGENTS
Provided are compositions that include polymeric fibers and microspheres entrapped within the fibers, the compositions being capable of controlled delivery of one or more agents while also...
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8158130 |
Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins
Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular...
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8158119 |
Cardiac targeted delivery of cells
A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and...
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8150522 |
Active control of epileptic seizures and diagnosis based on critical systems-like behavior
Developing a measure of critical systems-like behavior in an epilepsy patient in order to map epileptic networks, either passively or evoking responses through subthreshold stimulation, and to...
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8148982 |
Spin locked balanced steady-state free precession (slSSFP) with off-resonance spin locked pulses interleaved with imaging gradients
A spin locked balanced steady-state free precession (slSSFP) pulse sequence combines a balanced gradient echo acquisition with an off-resonance spin lock pulse for fast MRI. The transient and...
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8147823 |
Method of treating or retarding the development of blindness
A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal...
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US20120075703 |
OPTICAL DEVICE USING LATERALLY-SHIFTABLE DIFFRACTION GRATINGS
A double-sided grating divider acts as a light switch where the upper and lower grating dividers are arranged to accommodate a relative lateral shift therebetween of about one-fourth of the period...
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8145436 |
Method and systems for identifying micro-RNA targets and synthesizing novel micro-RNAs and uses of the same
Method of identifying a microRNA-recognition element and of generating microRNAs are disclosed. System and computer programs for performing such methods are disclosed. Recombinant nucleic acid...
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8138361 |
C-10 carbamates of taxanes
Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer...
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8137972 |
Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating...
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US20120065133 |
Artificial Oxygen Transport Protein
This invention provides heme-containing peptides capable of binding molecular oxygen at room temperature. These compounds may be useful in the absorption of molecular oxygen from molecular...
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US20120064033 |
MODULATION OF REGULATORY T CELLS BY HUMAN IL-18
The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject.
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8135452 |
Rapid 3-dimensional bilateral breast MR imaging
Provided is a method for rapid, 3D, dynamic, projection reconstruction bilateral breast imaging using simultaneous multi-slab volume excitation and radial acquisition of a contrast enhanced...
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8133723 |
Vaccines against multiple subtypes of influenza virus
An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA...
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8133687 |
Labor biomarkers, methods comprising same, and methods targeting same
The present invention provides methods of predicting or detecting labor in a female subject and methods of testing a compound for an ability to delay the onset of labor. The present invention also...
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8133482 |
Activatable photodynamic therapy agents
The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for...
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US20120058102 |
PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus composition(s) engineered with a built-in...
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8129185 |
Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and...
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US20120053502 |
PERFUSION CIRCUIT AND USE THEREIN IN TARGETED DELIVERY OF MACROMOLECULES
A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for...
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8124742 |
Rh(D)-binding proteins
The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.
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8124105 |
Compositions, methods and kits relating to poxvirus subunit vaccines
The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such...
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8124056 |
High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or...
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US20120046349 |
COMPOSITIONS FOR TARGETING CONDUCTING AIRWAY CELLS COMPRISING ADENO-ASSOCIATED VIRUS CONSTRUCTS
An artificial AAV capsid comprising a heterologous conducting airway targeting sequence is provided. The artificial AAV is useful as a targeting moiety, for delivery of heterologous molecules which...
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8119395 |
Vaccines, immunotherapeutics and methods for using the same
Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines,...
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8119348 |
Compositions and methods for diagnosing and treating macular degeneration
The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular...
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8118866 |
Method for heart valve implantation
A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body...
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8117854 |
System and method for producing and determining cooling capacity of two-phase coolants
The invention provides systems and devices for producing two-phase coolants such as an ice slurry. Also provided are methods for producing two-phase coolants, and methods for using the two-phase...
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US20120039986 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOPOIETIN 1 AND 2 AND THEIR RECEPTOR TIE2
RNA interference using small interfering RNAs which are specific for mRNA produced from the Ang1, Ang2 or Tie2 genes inhibits expression of these genes. Diseases which involve Ang1, Ang2 or Tie2...
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US20120038987 |
OPTICAL DEVICE USING DOUBLE-GROOVE GRATING
Optical devices using double-groove diffraction gratings having periodic sets of TiO2 elements on one or more surfaces of an SiO2 substrate are disclosed. First order components of incident...
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