Patents and Patent Applications from University of Pennsylvania


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9839367 Flexible and scalable sensor arrays for recording and modulating physiological activity  
An implantable sensor array incorporates active electronic elements to greatly increase the number of sensors and their density that can be simultaneously recorded and activated. The sensors can...
US20170348387 AAV-MEDIATED GENE THERAPY FOR NPHP5 LCA-CILIOPATHY  
Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with Leber congenital amaurosis (LCA) in a subject. The methods...
9834610 Fusion proteins for modulating regulatory and effector T cells  
The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain aspects, the proteins of the invention...
US20170343565 BIOMARKERS FOR SEIZURES  
The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood...
US20170343533 FLUID SEPARATOR FOR POINT OF CARE MOLECULAR DIAGNOSTICS  
The present disclosure provides devices and methods using Plasma coil r separating a fluid—e.g., plasma or serum—from whole blood. In some embodiments, the devices and methods use hydrophobic or...
US20170342436 TRANSGENIC PLANTS EXHIBITING ENHANCED PHYTOCHELATIN-BASED HEAVY METAL TOLERANCE AND METHODS OF USE THEREOF  
Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.
US20170342124 Universal Immune Receptor Expressed by T Cells for the Targeting of Diverse and Multiple Antigens  
The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the...
9830813 Smart and scalable urban signal networks: methods and systems for adaptive traffic signal control  
Scalable urban traffic control system has been developed to address current challenges and offers a new approach to real-time, adaptive control of traffic signal networks. The methods and system...
9827321 Stabilizing shear-thinning hydrogels  
The present inventions are directed to shear-thinning and stabilizing hydrogels, especially for use in drug delivery and therapy. Various embodiments provide settable, shear-thinning hydrogels,...
9827212 Compositions and methods for treating asthma and other lung diseases  
The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which...
US20170335395 A PARKINSON'S DISEASE DIAGNOSTIC BIOMARKER PANEL  
The present invention relates to a method of diagnosing Parkinson's disease in a subject using a novel set of biomarkers. The invention further includes compositions, methods and uses of a novel...
US20170335331 Altering Gene Expression in CART Cells and Uses Thereof  
The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group...
US20170335281 TREATMENT OF CANCER USING CHIMERIC ANTIGEN RECEPTOR  
The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen...
US20170334980 ANTI-PROPERDIN ANTIBODIES AND USES THEREOF  
This invention relates to selective inhibition of the alternative pathway (AP) of the complement system using an anti-properdin antibody. Specifically, the invention relates to methods of treating...
US20170334967 TREATMENT OF CANCER USING GFR ALPHA-4 CHIMERIC ANTIGEN RECEPTOR  
The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the Glycosyl-phosphatidylinositol (GPI)-linked GDNF...
US20170334890 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION  
Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general...
US20170333450 COMPOSITIONS AND METHODS FOR TREATING HIV-ASSOCIATED COGNITIVE DYSFUNCTION  
The present invention provides methods comprising treating and/or preventing cognitive dysfunction in subjects infected with HIV by administering an antioxidant inflammation modulator (AIM). The...
US20170332981 A METHOD AND DEVICE FOR MAGNETIC RESONANCE IMAGING DATA ACQUISITION GUIDED BY PHYSIOLOGIC FEEDBACK  
An adaptive real-time radial k-space sampling trajectory (ARKS) can respond to a physiologic feedback signal to reduce motion effects and ensure sampling uniformity. In this adaptive k-space...
9823260 Method to increase bioavailability of the delta-opioid receptor for management of pain and neuropsychiatric disorders  
Described herein is a method to induce surface trafficking of the delta-Opioid Receptor (DOR) and its applications, including, leveraging the antinociceptive potential of DOR agonists to treaty...
9821031 Methods and compositions for treating hypoglycemic disorders  
This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the...
US20170327842 PURIFICATION AND PURITY ASSESSMENT OF RNA MOLECULES SYNTHESIZED WITH MODIFIED NUCLEOSIDES  
This invention provides purified preparations of an RNA, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside, and methods of assessing purity of purified preparations of an...
US20170326253 PH-SENSITIVE PEPTIDES AND THEIR NANOPARTICLES FOR DRUG DELIVERY  
A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH-sensitive hydrophilic and hydrophobic...
9815901 Treatment of cancer using a CD123 chimeric antigen receptor  
The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors...
US20170322141 Measuring HIV Reservoirs with Optical Scanning  
Devices, systems and methods detect latent HIV in a patient on anti-retroviral therapy (ART), the method comprising using optical scanning to identify in a cell sample of the patient Gag+CD4...
US20170319701 DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF  
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides...
US20170319700 DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF  
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides...
US20170319684 Novel Artificial Antigen Presenting Cells and Uses Thereof  
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each...
US20170319319 SYSTEMS AND METHODS FOR MESH AUGMENTATION AND PREVENTION OF INCISIONAL HERNIA  
Techniques for mesh augmentation and prevention of incisional hernia, including systems and methods for affixing mesh to a fascial incision. A mesh strip can be integrated with one or more...
US20170319058 APPARATUS AND METHODS FOR TESTING VISUAL FUNCTION AND FUNCTIONAL VISION AT VARYING LUMINANCE LEVELS  
A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a...
US20170312303 COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF  
In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
9806314 Polymerized ionic liquid block copolymers as battery membranes  
The present invention is directed to compositions useful for use in separators for use in lithium ion batteries, and membranes, separators, and devices derived therefrom.
US20170309025 VIVO DETECTION OF EGFR MUTATION IN GLIOBLASTOMA VIA MRI SIGNATURE CONSISTENT WITH DEEP PERITUMORAL INFILTRATION  
A method, including a computer-implemented method, is provided for in vivo detection of epidermal growth factor receptor (EGFR) mutation status within peritumoral edematous tissue of a patient....
US20170306416 BIOMARKERS PREDICTIVE OF THERAPEUTIC RESPONSIVENESS TO CHIMERIC ANTIGEN RECEPTOR THERAPY AND USES THEREOF  
Cancer biomarkers and methods of using them are disclosed.
US20170306354 ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR  
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production...
US20170305971 POTENT COMPSTATIN ANALOGS  
Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement...
US20170304825 APPARATUS AND METHODS FOR MANUFACTURING A MICROFLUIDIC DEVICE  
A microfluidic device includes an integrated circuit and a first substrate layer having a first surface and a second surface. The first surface of the first substrate layer is connected to the...
US20170304777 METHOD OF STEM-BASED DRILLING OF ULTRATHIN SILICON NITRIDE NANOPORES AND NANOPORE ARRAYS  
The invention concerns methods for preparing a nanoporous silicon nitride membrane comprising (i) ablating portions of at least one side of the membrane with an electron beam to reduce the...
9797887 High-throughput methodology for identifying RNA-protein interactions transcriptome-wide  
Methods of identifying RNA-protein interaction sites are provided. Systems for identifying RNA-protein interaction sites are provided. Systems for identifying secondary structures are provided....
9797187 Devices for modulation of temperature and light based on phase change materials  
Devices that incorporate phase change materials in containment vessels promote conduction of thermal energy between the phase change materials within the containment vessels and the surrounding...
9796851 Hydraulic crumb silicone and orthotics comprising same  
The invention concerns cushioning compositions comprising (a) at least one of urethane polymer and silicone polymeric putty; and (b) hydraulic silicone crumb; said hydraulic silicone crumb being...
US20170299732 APPARATUS AND METHODS FOR MEASURING DELIVERED IONIZING RADIATION  
A dosimeter includes a substrate and a plurality of nanowire pairs located on the substrate. The plurality of nanowire pairs simulate a plurality of human chromosome pairs. A method of determining...
US20170299602 Biomimetic Chemical Sensors Using Nanoelectronic Readout of Olfactory Receptors  
The present invention provides biomimetic sensor devices that utilize proteins—such G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These...
US20170298454 COMPOSITIONS AND METHODS FOR ISOLATION OF CIRCULATING TUMOR CELLS (CTC)  
A method useful for identifying and isolating live circulating tumor cells is described. The method utilizes an adenoviral vector comprising a replication-competent adenovirus in which the E1 gene...
US20170298388 METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY  
Adeno-associated virus rh.20 sequences, vectors containing same, and methods of use are provided.
US20170298374 COMPOSITIONS AND METHODS OF DELIVERING MOLECULES TO PLANTS  
Compositions and method of delivering a molecule to a plant are provided. In an embodiment, an avenic acid transporter is introduced into a plant. The plant may be a non-graminacious or...
US20170298056 SMALL MOLECULE INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF  
Described herein are small-molecule compounds that specifically inhibit a wide range of HIV-1 isolates without interfering with CD4 or CCR5 binding. Methods of using die compounds for treating or...
US20170296746 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PHYSIOLOGY PARAMETER-INVARIANT MEAL DETECTION  
Methods, systems, and computer readable media for physiology parameter-invariant meal detection are disclosed. According to one system, the system includes at least one processor and a meal...
US20170296675 TARGETED CARRIERS FOR INTRACELLULAR DRUG DELIVERY  
The invention provides a method for delivering a cargo molecule into a cell using a targeted DNA-based carrier (e.g., DNA dendrimer). Compositions and kits useful in the practice of the methods...
9792681 System and method for medical image analysis and probabilistic diagnosis  
Methods and systems for obtaining a probabilistic diagnosis based on medical images of a patient are disclosed. In exemplary embodiments, such methods include the steps of scanning some or all of...
9790472 Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby  
Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.