Patents and Patent Applications from University of Pennsylvania


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9792681 System and method for medical image analysis and probabilistic diagnosis  
Methods and systems for obtaining a probabilistic diagnosis based on medical images of a patient are disclosed. In exemplary embodiments, such methods include the steps of scanning some or all of...
9790472 Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby  
Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.
9790267 Glypican-3-specific antibody and uses thereof  
The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of GPC3. The invention provides...
9790110 Processes and treatment systems for treating high phosphorous containing fluids  
Disclosed herein are processes for treating high-P fluid involving (1) providing a high-P containing stream; (2) chemically treating the high-P stream such that a majority of dissolved P in the...
9789175 Synthetic immunogens for prophylaxis or treatment of tuberculosis  
Compositions comprising a nucleic acid molecule that encodes TB esat-6 proteins are disclosed. Methods of inducing an immune response against TB an individual are disclosed. Method of treating an...
US20170293563 TECHNIQUES FOR METADATA PROCESSING  
Techniques are described for metadata processing that can be used to encode an arbitrary number of security policies for code running on a processor. Metadata may be added to every word in the...
US20170292132 TISSUE PREFERENTIAL CODON MODIFIED EXPRESSION CASSETTES, VECTORS CONTAINING SAME, AND USES THEREOF  
Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an...
US20170291954 Glypican-3 Antibody And Uses Thereof  
The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (GPC3). The invention also includes a chimeric antigen...
US20170290858 Altering Gene Expression in Modified T Cells and Uses Thereof  
The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group...
9783610 Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof  
The invention relates to variants of an antibody or antigen-binding fragment that binds specifically to an endosialin tumor endothelial marker 1 (TEM1), and prophylactic, diagnostic, and...
9783591 Use of the CD2 signaling domain in second-generation chimeric antigen receptors  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an...
US20170285124 EDEMA INVARIANT TRACTOGRAPHY  
Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a...
US20170283775 Compositions and Methods for Treatment of Cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
US20170281793 ANTI-TEM1 ANTIBODIES AND USES THEREOF  
The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.
US20170281691 METHODS FOR CONSTRUCTING ANTIBIOTIC RESISTANCE FREE VACCINES  
The present invention provides Listeria vaccine strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same.
9779496 Semi-automated heart valve morphometry and computational stress analysis from 3D images  
A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets...
9778335 Enhanced nuclear spin polarization  
The polarization of nuclear spins of a material may be enhanced by encapsulating the material within a reverse micelle.
9777061 Treatment of cancer using a CD33 chimeric antigen receptor  
The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors...
9777034 Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes  
The invention concerns compounds of the formula (I) wherein: Y1 and Y2 are independently a monosaccharide or disaccharide; X1 and X2 are independently —(R9—O)m—, —(R10)p—, —O—(R11—O)q—,...
9776963 Small molecule CD4 mimetics and uses thereof  
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
US20170275686 METHODS FOR DETECTING GENOMIC DNA METHYLATION  
The presently disclosed subject matter provides high-throughput methods for performing genomic DNA methylation assessments. The presently disclosed subject matter further provides methods for...
US20170275252 ASYMMETRIC BISAMINOQUINOLINES AND BISAMINOQUINOLINES WITH VARIED LINKERS AS AUTOPHAGY INHIBITORS FOR CANCER AND OTHER THERAPY  
The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are...
US20170274014 COMBINATIONS OF LOW, IMMUNE ENHANCING, DOSES OF MTOR INHIBITORS AND CARS  
The invention relates, in part, to a method of treating a subject comprising administering to the subject a low, immune enhancing of a mTOR inhibitor and an immune effector cell engineered to...
9772335 Biomarkers for seizures  
The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood...
9770491 AAV-mediated gene therapy for RPGR X-linked retinal degeneration  
Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with retinitis pigmentosa and x-linked retinitis pigmentosa in a...
9770011 Veterinary composition and methods for non-surgical neutering and castration  
A method for non-surgical neutering or castration of a non-human mammal for AAV-mediated delivery of an anti-GnRH polypeptide to a non-human animal is described. More particularly, the animal is...
US20170266406 NASAL AIR JET INSUFFLATOR  
The present invention provides an apparatus for nasally delivering a supraglottic jet ventilation and methods of treating breathing disorders by utilizing the apparatus for nasally delivering a...
US20170266282 DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME  
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by...
9765156 Enhancing activity of CAR T cells by co-introducing a bispecific antibody  
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor...
US20170261508 METHODS FOR MONITORING CD4+ T-HELPER TYPE 1 RESPONSE IN CANCER AND IMMUNE RESTORATION  
A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer CD4+ Th1 response from antigen presenting cells or...
US20170260347 NANOCOMPOSITE FILMS AND METHODS FOR PRODUCING THE SAME  
A method of producing a nanocomposite film includes generating a bilayer film including at least a first layer of at least one nanoparticle and a second layer of at least one material and...
US20170260221 Ruthenium-Based Photolinkers and Methods of Use  
The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use. In certain aspects, the compositions...
US20170258921 Protease Triggered Release Of Molecules From Hydrogels  
The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a...
US20170258893 MERS-CoV Vaccine  
Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike...
US20170258836 COMPOSITIONS AND METHODS OF STIMULATING AND EXPANDING T CELLS  
The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a...
US20170258835 METHODS AND COMPOSITIONS FOR MODIFIED T CELLS  
The present invention relates to compositions and methods for generating modified cells with nucleic acid encoding a T cell receptor (TCR), a nucleic acid encoding a bispecific antibody, affinity...
US20170258821 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE  
The invention provides compositions and methods for radioprotection and chemoprevention using therapeutic and prophylactics methods of using (S,S)-SDG (R,R)-SDG, (S,R)-SDG (R,S)-SDG, SDG, SECO,...
US20170258776 Methods for Treating Disorders or Diseases Associated with Hyperlipidemia and Hypercholesterolemia While Minimizing Side Effects  
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to...
9761008 Methods, systems, and computer readable media for visual odometry using rigid structures identified by antipodal transform  
The subject matter described herein includes methods for visual odometry using rigid structures identified by an antipodal transform. One exemplary method includes receiving a sequence of images...
9758828 Methods to detect, treat and prevent acute cellular rejection in kidney allografts  
Methods for prevention and treatment of kidney transplant rejection are described that involve determination, analysis and computation of a 3-gene molecular signature of levels of specific RNAs...
9758724 Morphologically and size uniform monodisperse particles and their shape-directed self-assembly  
Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their...
US20170254796 Ultra Low Capacitance Glass Supported Dielectric Membranes For Macromolecular Analysis  
Provided are suspended solid-state membranes on glass chips with improved capacitance. Also provided are related methods of fabricating and using the disclosed chips.
US20170254740 SITU TRIBOMETER AND METHODS OF USE  
Techniques for determining a characteristic of a sample using an atomic force microscope including a cantilever having a probe attached thereto, including positioning the sample within a cell and...
US20170253876 Transcriptome In Vivo Analysis (TIVA) and Transcriptome In Situ Analysis (TISA)  
Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule...
9751830 Inhibitors of the tumor necrosis factor receptor complex  
The present invention relates to compounds of formula (I) that are inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and...
9750824 RNA containing modified nucleosides and methods of use thereof  
This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing...
9750795 Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections  
Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are...
US20170247413 COMPSTATIN ANALOGS WITH IMPROVED PHARMACOKINETIC PROPERTIES  
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus contains an added...
US20170246690 STABILIZING AGENT-FREE METAL NANOPARTICLE SYNTHESIS AND USES OF METAL NANOPARTICLES SYNTHESIZED THEREFROM  
Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the...
US20170245810 IMPROVED SUPER-RESOLUTION TOMOSYNTHESIS IMAGING SYSTEMS AND METHODS  
A super-resolution digital tomosynthesis system for imaging an object including a source configured to emit penetrating particles toward an object; a detector configured to acquire a series of...