Patents and Patent Applications from University of Pennsylvania


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US20180175319 SPECTRAL EMISSION MODIFICATION USING LOCALIZED SURFACE PLASMON OF METALLIC NANOPARTICLES  
A method for engineering a line shape of emission spectrum of an organic emissive material in an electroluminescent device is disclosed in which a layer of plasmonic metallic nanostructures having...
US20180174851 THIN FILM METAL SILICIDES AND METHODS FOR FORMATION  
The disclosed subject matter provides thin films including a metal silicide and methods for forming such films. The disclosed subject matter can provide techniques for tailoring the electronic...
US20180171294 IN VITRO ARTIFICIAL LYMPH NODE METHOD FOR SENSITIZATION AND EXPANSION OF T CELLS FOR THERAPY AND EPITOPE MAPPING  
A method of creating a microenvironment for culture expansion of T cells. The expanded T cells can be used for a variety of therapeutic and research purposes.
US20180169222 METHODS AND COMPOSITIONS FOR STIMULATING IMMUNE RESPONSE USING POTENT IMMUNOSTIMULATORY RNA MOTIFS  
The presently disclosed subject matter relates to methods and compositions relating to immunostimulatory RNA motifs that act as adjuvants and/or immunostimulatory agents to enhance host immune...
US20180169024 MECHANO-SENSITIVE MICROCAPSULES FOR DRUG DELIVERY  
Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to...
9999779 Cell, tissue and organ protection using a magnetic field  
Methods and apparatus are provided for applying low magnetic fields (<400 G) to mammalian cells, tissues and organs for protection from the damaging effects of ionizing radiation and other oxygen...
9999756 System for delivery of gaseous imaging contrast agents and methods for using same  
Systems and methods for delivering a gaseous contrast agent to the lungs of a subject.
US20180163202 Compositions and Methods for Degradation of Misfolded Proteins  
The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder...
US20180162818 211-ASTATINE CONTAINING RADIOTHERAPEUTICS FOR THE TREATMENT OF CANCER  
Described herein is an alpha-emitting radionuclide, 211At, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described...
US20180162800 Use of the Irritating Principal Oleocanthal in Olive Oil, as Well as Structurally and Functionally Similar Compounds  
The invention provides methods of synthesizing the purified enantiomers of oleocanthal. The invention further provides methods of using oleocanthals in various formulations including, food...
US20180162726 HYBRID NANOPARTICLES CONTAINING DENDRONS, METHODS OF PRODUCING SUCH HYBRID NANOPARTICLES, AND USES THEREOF  
The present disclosure relates to a hybrid nanoparticle comprising a metallic core and at least one lipophilic dendron attached to the surface of the metallic core, and methods of producing such...
US20180161397 METHODS FOR MODULATING AN INFLAMMATORY RESPONSE  
The inventive subject matter relates to novel methods for modulating an immune response in an animal, which comprises administering to said animal an effective amount of an agent that increases...
9994818 ICOS critically regulates the expansion and function of inflammatory human Th17 cells  
The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is...
9994629 Compositions and methods for generating a synthetic antibody  
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by...
9994625 HSP104 variants and uses thereof  
Protein misfolding underpins several fatal neurodegenerative disorders. The application is directed to recombinant Hsp104 proteins comprising missense mutations aimed at correcting these events,...
9994619 Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof  
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences....
9993545 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom  
The present invention relates to synthetic, consensus foot-and-mouth disease virus (FMDV) immunogenic proteins and nucleic acid molecule encoding such proteins, to vaccines against FMDV, to...
9992932 Control arrangement and method for controlling a position of a transfer device of a harvesting machine  
An adjustable transfer device for unloading processed crop onto a container of a transport vehicle including a control arrangement with an electronic control unit, among other integrated...
9992931 Control arrangement and method for controlling a position of a transfer device of a harvesting machine  
An adjustable transfer device for unloading processed crop onto a container of a transport vehicle including a control arrangement with an electronic control unit, among other integrated...
US20180160530 Scalable, Printable, Patterned Sheet of High Mobility Graphene On Flexible Substrates  
The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses...
US20180155412 AAV-MEDIATED EXPRESSION OF ANTI-INFLUENZA ANTIBODIES AND METHODS OF USE THEREOF  
AAV vectors expressing anti-influenza antibodies are provided. Also described are pharmaceutical compositions useful in delivery same for prophylactic or anti-viral purposes. Methods of delivering...
US20180153974 Combination Therapies With Recombinant Listeria Strains  
The disclosure is directed to compositions comprising an oncolytic virus, chimeric antigen receptor T cells (CAR T cells), a therapeutic or immunomodulating monoclonal antibody, a targeting...
US20180153962 SYNERGISTIC COMBINATION OF NEURONAL VIABILITY FACTORS AND USES THEREOF  
The present invention relates to the synergistic combination of the short and long Rod-Derived Cone Viability Factors and to methods for treating retinal degenerative diseases.
9990856 Systems and methods for providing vibration feedback in robotic systems  
Systems and methods for training an operator of a robotic surgery system are disclosed. One such method includes enabling the operator to perform a test procedure, recording vibrations of a...
9987321 Use of flaxseed and flaxseed derivatives for treatment of neurological disorders and viral diseases  
The invention provides compositions and methods for treating neurological disorders and viral infection using whole-grain flaxseed, flaxseed lignans such as Secoisolariciresinol diglucoside (SDG),...
9986924 Implantable biomedical devices on bioresorbable substrates  
Provided herein are implantable biomedical devices and methods of administering implantable biomedical devices, making implantable biomedical devices, and using implantable biomedical devices to...
9984283 Methods, systems, and computer readable media for automated detection of abnormalities in medical images  
Methods, systems, and computer readable media for automated detection of abnormalities in medical images are disclosed. According to a method for automated abnormality detection, the method...
9983219 Biomarkers for seizures  
The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood...
9983215 Methods and compositions for diagnosis of ectopic pregnancy  
Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of the selected genes, gene fragments or transcripts or expression...
9982256 Random RNAi libraries, methods of generating same, and screening methods utilizing same  
This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and...
9981036 Compositions, comprising improved Il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same  
Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL 12 p40...
9981024 Compositions comprising angiogenic factors and methods of use thereof  
The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising...
US20180140602 COMBINATION OF CHIMERIC ANTIGEN RECEPTOR THERAPY AND AMINO PYRIMIDINE DERIVATIVES  
The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein,...
9979039 Direct carbon fuel cell and stack designs  
Disclosed are novel configurations of Direct Carbon Fuel Cells (DCFCs), which optionally comprise a liquid anode. The liquid anode comprises a molten salt/metal, preferably Sb, and a fuel, which...
9976176 Isothermal nucleic acid amplification reactor with integrated solid state membrane  
Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic...
9975848 Inhibitors of HIV-1 entry and methods of use thereof  
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against...
US20180135030 COMPOSITIONS USEFUL IN TREATMENT OF ORNITHINE TRANSCARBAMYLASE (OTC) DEFICIENCY  
Non-viral delivery systems comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine...
US20180133307 Influenza Nucleic Acid Molecules and Vaccines Therefrom  
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also...
US20180129894 Methods and System for Detecting Curved Fruit with Flash and Camera and Automated Image Analysis with Invariance to Scale and Partial Occlusions  
This invention relates to a system and method for detecting the curved surfaces of fruit using a flash and camera system and automated image analysis. Lighting upon fruit is controlled, with a...
US20180127676 NANO-ADDITIVES ENABLED ADVANCED LUBRICANTS  
The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to...
US20180127577 BIJELS AND METHODS OF MAKING THE SAME  
A method of making a bijel includes dispersing surface-active nanoparticles in a ternary liquid mixture. The ternary liquid mixture includes a hydrophilic liquid, a hydrophobic liquid, and a...
US20180126037 DECELLULARIZED ORGAN-DERIVED TISSUE ENGINEERING SCAFFOLDS  
The presently disclosed subject matter provides for decellularized extracellular matrix (dECM) compositions for reconstructing mucosal tissue of trachea and methods of using the same. In certain...
US20180125984 DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF  
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides...
US20180125892 TREATMENT OF CANCER USING CHIMERIC ANTIGEN RECEPTORS  
The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or...
US20180118834 PHOSPHOGLYCERATE KINASE 1 (PGK) PROMOTERS AND METHODS OF USE FOR EXPRESSING CHIMERIC ANTIGEN RECEPTOR  
The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a...
US20180118785 COMPSTATIN ANALOGS WITH IMPROVED ACTIVITY  
Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. These compounds display improved complement...
9957546 Vivo detection of phospholipase activation  
The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone...
9956187 Compositions and methods for treating opioid receptor associated diseases  
The invention relates to dezocine compositions and uses thereof. Specifically, the invention relates to dezocine compositions, including nano-dezocine compositions and methods for preventing or...
US20180113130 COMPOSITIONS, METHODS AND MICROFLUIDICS DEVICE FOR TELOMERASE BASED IN VITRO DIAGNOSTIC ASSAYS FOR DETECTING CIRCULATING TUMOR CELLS (CTC)  
A repeatable method for detecting circulating tumor cells in vitro is provided. The method involves combining a test sample from a patient suspected of having circulating tumor cells, and a...
US20180111976 IDENTIFICATION OF IMMUNOGENIC MHC CLASS II PEPTIDES FOR IMMUNE-BASED THERAPY  
The invention provides compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER3 protein....