Patents and Patent Applications from University of Pennsylvania


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10078763 Programmable unit for metadata processing  
A system and method for metadata processing that can be used to encode an arbitrary number of security policies for code running on a stored-program processor. This disclosure adds metadata to...
10076565 Vaccines against multiple subtypes of influenza virus  
An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA...
US20180259540 BIOMARKERS FOR SEIZURES  
The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood...
US20180258441 PHARMACEUTICAL PROTEINS, HUMAN THERAPEUTICS, HUMAN SERUM ALBUMIN INSULIN, NATIVE CHOLERA TOXIN B SUBUNIT ON TRANSGENIC PLASTIDS  
This invention relates in part to synthesizing high value pharmaceutical proteins in transgenic plants by chloroplast expression for pharmaceutical protein production. We use poly(GVGVP), for...
US20180258391 Compositions and Methods for Treatment of Cancer  
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the...
US20180258149 CAR T CELL THERAPIES WITH ENHANCED EFFICACY  
The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use...
US20180256712 Toxicity Management for Anti-Tumor Activity of CARs  
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need...
10071953 Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof  
The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor...
10071154 Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same  
Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid...
US20180252727 BIOMARKERS PREDICTIVE OF CYTOKINE RELEASE SYNDROME  
The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical...
US20180251508 AAV-EPO FOR TREATING COMPANION ANIMALS  
Compositions and methods are provided for treating companion animals are provided. An adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence...
US20180250339 METHODS AND COMPOSITIONS FOR GENE EDITING IN HEMATOPOIETIC STEM CELLS  
The present invention relates to compositions and methods of generating modified hematopoietic stem or progenitor cells. One aspect of the invention includes a modified hematopoietic stem or...
US20180250336 COMPOSITIONS AND METHODS OF ENHANCING ANTI-TUMOR RESPONSE USING HYBRID NEUTROPHILS  
The present invention relates to compositions and methods that provide novel anti-tumor therapies in cancer. In one aspect, the present invention features a hybrid neutrophil in a non-naturally...
10069635 Methods and systems for achieving system-level counterfeit protection in integrated chips  
According to embodiments of the present invention are systems and methods for using scan chains for the creation of unique physically uncloneable function (PUF). In particular, the present...
10066163 Morphologically and size uniform monodisperse particles and their shape-directed self-assembly  
Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their...
10064931 Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections  
Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are...
10064898 Listeria-based adjuvants  
This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.
10064554 Fiber optic flow and oxygenation monitoring using diffuse correlation and reflectance  
Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such...
US20180246392 OPTOMECHANICAL DOUBLY RESONANT 2D FREQUENCY DOUBLING DEVICES  
Optomechanical device for frequency doubling enhancement are described. The devices include a substrate through which light of a first wavelength is introduced, a first reflector mirror, a...
US20180245129 IN VIVO DETECTION OF PHOSPHOLIPASE ACTIVATION  
The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone...
US20180244995 DIRECT MAPPING OF LOCAL DIRECTOR FIELD OF NEMATIC LIQUID CRYSTALS AT THE NANOSCALE  
The present disclosure is directed to mesogenic compounds having a structure of Formula (I), (II) or (III): where A, B, X1, L, TG, m, and n are defined herein, and compositions containing these...
US20180244876 A ROBUST SMART FILM: REVERSIBLY SWITCHING FROM HIGH TRANSPARENCY TO ANGLE-INDEPENDENT STRUCTURAL COLOR DISPLAY  
Switchable optical materials, which possess reversible light transmission in response to external stimuli are of wide interest for potential applications such as energy efficient windows,...
US20180244748 Modified Monocytes/Macrophage Expressing Chimeric Antigen Receptors and Uses Thereof  
The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage...
US20180243440 METHODS AND COMPOSITIONS FOR DRUG DELIVERY  
Compositions comprising a red blood cell (RBC) having non-toxically coupled thereto a nanoparticle having a low shear modulus or low Young's modulus of less than 10 MPa and containing a drug are...
US20180243416 NOVEL AAV MEDIATED INFLUENZA VACCINES  
A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at...
US20180243411 Toxicity Management for Anti-Tumor Activity of CARs  
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need...
US20180243341 Methods and Compositions for Cells Expressing a Chimeric Intracellular Signaling Molecule  
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By expressing an chimeric antigen receptor and...
US20180243327 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE  
The invention relates to the use of secoisolariciresinol diglucoside (SDG), other active components in flaxseed, and related compounds for treating proton radiation associated lung injury and...
10060939 Device and method for clinical data sampling and specimen banking  
A system and method are described that allow the autonomous collection of relevant data and samples from a patient during a clinical trial or during routine care. Sampling is accomplished by...
10058622 PH-sensitive peptides and their nanoparticles for drug delivery  
A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH-sensitive hydrophilic and hydrophobic...
10058576 Compositions and methods comprising a defined microbiome and methods of use thereof  
The invention features the use of a defined microbial consortia for the replacement of a gut microbiome associated with disease. In particular, the invention provides for the treatment of...
US20180238905 METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ECTOPIC PREGNANCY  
Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of ISM2, ADAM12, PST1, PSG7, PST11, PSG9, PSG2 and other genes...
US20180236450 APPARATUS FOR GENERATING MICRODROPLETS AND METHODS OF MANUFACTURING  
Aspects of the present invention relate to apparatuses for microdroplet generation and methods of manufacturing such apparatuses. In accordance with one aspect, a method for manufacturing a...
US20180236106 RADIOGRAPHIC NANOPARTICLE CONTRAST AGENTS FOR DUAL-ENERGY X-RAY IMAGING AND COMPUTED TOMOGRAPHY SCANNING AND METHODS OF USING THEREOF  
Nanoparticles and nanoprobes for use as a contrast agent for X-ray imaging techniques, CT scanning techniques, MRI and optical imaging are disclosed. The nanoparticles and nanoprobes include a...
10053406 Synthesis of honokiol  
Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol,...
US20180230488 GLP-1 AND USE THEREOF IN COMPOSITIONS FOR TREATING METABOLIC DISEASES  
Compositions and methods for treating type II diabetes in a subject. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a propeptide and the active...
US20180230415 FIBROSIS MODEL ON A CHIP  
The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model...
10047052 Bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use  
The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods...
10046053 Protease triggered release of molecules from hydrogels  
The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a...
10046013 Engineered bacteria for oral delivery of glucoregulatory proteins  
Disclosed is an oral delivery system that overcomes major barriers encountered in the gastrointestinal tract, particularly rapid proteolytic degradation and low intestinal permeability. Provided...
10046008 Methods for treating chronic lymphocytic leukemia (CLL)  
The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
10045951 Flaxseed lignan complex and its use thereof  
The invention relates compositions and methods for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans. Specifically, the invention relates to the dietary use of...
US20180227693 Sound Propagation and Perception For Autonomous Agents In Dynamic Environments  
Methods and systems for sound propagation and perception for autonomous agents in dynamic environments are described. Adaptive discretization of continuous sound signals allows one to obtain a...
US20180223251 SYSTEMS AND METHODS FOR IMMOBILIZING EXTRACELLULAR MATRIX MATERIAL ON ORGAN ON CHIP, MULTILAYER MICROFLUIDICS MICRODEVICES, AND THREE-DIMENSIONAL CELL CULTURE SYSTEMS  
The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spatial geometry and microarchitecture of 3D collagen hydrogels. For example,...
US20180221239 GAIT REHABILITATION SYSTEMS, METHODS, AND APPARATUSES THEREOF  
Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for...
10043250 Interactive non-uniformity correction and intensity standardization of MR images  
Interactive non-uniformity correction (NC) and interactive intensity standardization (IS) require sample tissue regions to be specified for several different types of tissues. Interactive NC...
10041090 Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby  
Adeno-associated virus rh.8 sequences, vectors containing same, and methods of use are provided.
10040859 Methods of treating hemophagocytic lymphohistiocytosis with an IL-33 receptor antibody  
Compositions and methods for treating a cytokine release syndrome such as chimeric antigen receptor T-cell cytokine release syndrome or hemophagocytic lymphohistiocytosis are provided.
10040846 Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer  
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane...
10040828 Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same  
Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that...