Patents and Patent Applications from University of Pennsylvania


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US20190345491 MODIFIED IMMUNE CELLS HAVING ENHANCED FUNCTION AND METHODS FOR SCREENING FOR SAME  
The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen...
US20190345219 SWITCH COSTIMULATORY RECEPTORS  
The present invention relates generally to a fusion protein that when displayed on a cell can convert a negative signal into a positive signal in the cell. The fusion protein is a chimeric protein...
US20190344342 DENDRONS FOR TUNING THE MAGNETIC PROPERTIES OF NANOPARTICLES AND HYBRID NANOPARTICLES FORMED THEREFROM  
The present disclosure relates to a hybrid nanoparticle comprising: (a) a metallic core or a metal oxide core, and (b) at least one dendron attached to the surface of the metallic core or metal...
US20190343966 GENE THERAPY FOR TREATING HEMOPHILIA A  
Compositions and regimens useful in treating hemophilia A are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving...
US20190343920 AAV-MEDIATED GENE THERAPY FOR NPHP5 LCA-CILIOPATHY  
Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with Leber congenital amaurosis (LCA) in a subject. The methods...
10473590 Apparatus and methods for analyzing the output of microfluidic devices  
Microfluidic devices for analyzing droplets are disclosed. A described microfluidic device includes a substrate and a microfluidic channel formed on the substrate. The microfluidic channel...
10471279 Proton dose imaging method and apparatus  
Particle therapy systems and methods for particle dose imaging are provided. A particle therapy system includes a particle beam source for generating a particle beam; and at least one particle...
10470676 Noninvasive 4-D time-resolved dynamic magnetic resonance angiography  
A method for non-contrast enhanced 4D time resolved dynamic magnetic resonance angiography using arterial spin labeling of blood water as an endogenous tracer and a multiphase balanced steady...
US20190340957 Methods and Devices for Modeling the Eye  
The presently disclosed subject provides a biomimetic eye model, and methods of its production and use. In one exemplary embodiment, the biomimetic eye model can include a scaffold having a convex...
US20190339269 COMPOSITIONS AND METHODS FOR PREDICTING RISK OF PRETERM BIRTH  
Compositions, kits and methods for diagnosing and treating an increased risk of preterm birth (PTB) involves a composition comprising at least one reagent capable of detecting, binding,...
US20190339246 Multiplexed Detection Of Toxins Using Graphene-Based Aptasensors  
Provided are aptamer-functionalized sensors, capable of detecting various analytes, including toxins, at comparatively low concentrations. Also provided are methods of fabricating and using such...
US20190338310 GENE THERAPY FOR TREATING WILSON'S DISEASE  
Compositions and regimens useful in treating Wilson's Disease are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving...
US20190336973 Magnetic Separation Filters For Microfluidic Devices  
A magnetic separation device has a membrane having a plurality of pores, a magnetically soft material layer disposed on the membrane, and a passivation layer disposed on the magnetically soft...
US20190336584 METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS  
This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the...
US20190336550 GENE THERAPY FOR TREATING PHENYLKETONURIA  
Compositions and regimens useful in treating phenylketonuria are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving...
US20190336530 METHODS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)  
The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
US20190336504 TREATMENT AND PREVENTION OF CYTOKINE RELEASE SYNDROME USING A CHIMERIC ANTIGEN RECEPTOR IN COMBINATION WITH A KINASE INHIBITOR  
The disclosure provides compositions and methods for treating diseases associated with expression of an antigen or for treating or prevent cytokine release syndrome, e.g., by administering a CAR...
US20190330356 TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRVIII CHIMERIC ANTIGEN RECEPTOR  
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII,...
US20190330300 Universal Immune Receptor Expressed by T Cells for the Targeting of Diverse and Multiple Antigens  
The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the...
US20190328906 THERAPY FOR FRONTOTEMPORAL DEMENTIA  
The invention provides methods and uses for delivering progranulin to the central nervous system (CNS) of a mammal. Methods and uses include, for example, administering to a mammal a vector...
US20190328855 Optimized Synthetic Consensus Immunogenic Compositions Targeting Fibroblast Activation Protein  
Provided herein is an immunogenic composition comprising a synthetic consensus FAP antigen. Also disclosed herein is a method of treating or preventing a tumor associated pathology in a subject in...
US20190328643 COMPOSITIONS AND METHODS FOR INHIBITING BIOLFILM DEPOSITION AND PRODUCTION  
The invention provides a method for combating biofilm, said method comprising contacting a biofilm with a composition comprising an effective amount of antimicrobial peptide biofilm enzyme...
10457729 Compositions and methods for treating cancer  
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα)...
10457642 211-astatine containing radiotherapeutics for the treatment of cancer  
Described herein is an alpha-emitting radionuclide, 211At, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described...
10456318 Gait rehabilitation systems, methods, and apparatuses thereof  
Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for...
US20190323025 COMPOSITIONS AND METHODS FOR DELIVERY OF MOLECULES TO PLANTS  
Compositions and methods are provided where a plant comprising an avenic acid transporter is planted in a field with a target plant in need of increased iron uptake. The plant comprising the...
US20190322725 COMPOSITIONS COMPRISING AAV EXPRESSING DUAL ANTIBODY CONSTRUCTS AND USES THEREOF  
A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also...
US20190320892 METHODS AND SYSTEMS FOR ASSESSING PHOTORECEPTOR FUNCTION  
A method for non-invasive assessment of photoreceptor function in a mammalian subject comprises exposing a subject's eye to a visible light stimulus to initiate an intrinsic reflectance response...
10449359 Method and apparatus for improving cognitive performance  
A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes...
10449224 Flaxseed lignan complex, methods of using and compositions thereof  
This invention relates to methods and compositions for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans (isolated in form of the lignan precursor...
10448823 Apparatus and methods for testing visual function and functional vision at varying luminance levels  
A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a...
US20190319556 ELECTROSTATIC CLUTCH  
An electrostatic clutch is described comprising a plurality of micron-scale thickness electrodes, adjacent electrodes being separated by a thin film of dielectric material. A power source and...
US20190315831 COMPOSITIONS AND METHODS OF CHIMERIC AUTOANTIBODY RECEPTOR T CELLS  
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors...
US20190315830 COMPOSITIONS AND METHODS OF CHIMERIC AUTOANTIBODY RECEPTOR T CELLS  
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors...
US20190315829 COMPOSITIONS AND METHODS OF CHIMERIC AUTOANTIBODY RECEPTOR T CELLS  
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors...
US20190314378 Gene Therapy For Mesothelioma  
Gene therapy based combination therapy for malignant pleural mesothelioma (“MPM”) that is resistant to or recurrent after chemotherapy employing a viral vector containing a human interferon...
US20190313957 USE OF MICRO-RIBONUCLEIC ACID (MIRNA) TO DIAGNOSE TRANSPLANT REJECTION AND TOLERANCE OF IMMUNOSUPPRESSION THERAPY  
The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus,...
US20190309041 COMPOSITIONS AND METHODS OF CHIMERIC AUTOANTIBODY RECEPTOR T CELLS  
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors...
US20190307870 SYNTHETIC MALARIA IMMUNOGENS, COMBINATIONS THEREOF, AND THEIR USE TO PREVENT AND TREAT MALARIA INFECTIONS  
Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune...
10437993 Methods, systems, and computer readable media for detecting covert timing channels  
A mechanism called time-deterministic replay (TOR) that can reproduce the execution of a program, including its precise timing. Without TOR, reproducing the timing of an execution is difficult...
US20190300879 METHODS FOR ENHANCING UTROPHIN PRODUCTION VIA INHIBITION OF MICRORNA  
This invention provides a method for enhancing utrophin protein production in a cell by inhibiting an utrophin microRNA molecule. Moreover, the invention provides that methods for enhancing...
US20190298715 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY  
Provided herein is the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor...
10426870 Biomaterials for enhanced implant-host integration  
The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure is provides compositions and...
10426823 Methods for constructing antibiotic resistance free vaccines  
The present invention provides Listeria vaccine strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same.
US20190292563 ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR  
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production...
US20190292257 METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR - EXPRESSING CELLS  
The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures...
US20190292250 AAV-ANTI-VEGF FOR TREATING CANCER IN COMPANION ANIMALS  
Compositions and methods are provided for treating hemangiosarcoma in a subject. A recombinant AAV comprising a capsid and a vector genome comprising a nucleic acid expression cassette is...
US20190292238 CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR)- EXPRESSING CELL  
The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein,...
US20190291092 Core-Shell Nanoparticulate Compositions And Methods  
Core-shell nanoparticulate compositions and methods for making the same are disclosed. In some embodiments core-shell nanoparticulate compositions comprise transition metal core encapsulated by...
US20190290769 Hydrogel Compositions  
Provided are compositions comprising a hydrogel formed from a cyclodextrin-modified branched polyethyleneimine and an adamantane-modified, eight-arm polyethyelene glycol. The hydrogel may contain...