Patents and Patent Applications from University of Oklahoma


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US20180198607 OPTICAL CRYPTOGRAPHY SYSTEMS AND METHODS  
Systems and methods for restoring or recovering linear polarization state of an optical signal as it exits the far end of an optical fiber are disclosed. The optical signal may have an expected...
US20180169140 ANTIBIOTIC COMPOSITIONS AND METHODS OF USE  
The present disclosure describes compositions comprising β-lactam antibiotics and branched poly-ethylenimines (BPEI), having efficacy against various Gram-positive bacteria, for example...
10000789 Cellular probe device, system and analysis method  
A sampling probe, system and analysis method is disclosed. The sampling probe in one embodiment is constructed of a silicon substrate having a first channel, a second channel, a first tapered tip...
9993148 Surgical retractor system and method  
A multiple piece tongue blade is described. The multiple piece tongue blade is provided with a step and a tip. The stem is adapted to be inserted into a handle of a surgical retractor. The tip is...
9987241 Enzyme conjugate and prodrug cancer therapy  
A method and composition for treating a cancerous tumor in a subject by targeting the tumor's vasculature using an enzyme conjugate comprising a ligand which binds to endothelial cells in the...
9982663 Electroosmotic pump unit and assembly  
An electroosmotic pump unit includes at least a first pump element, at least a second pump element, and an electrode. Each pump element includes a tube, an electrically grounded fluid inlet, a...
US20180141989 Variants of Adrenomedullin and Calcitonin Gene-Related Peptide and Methods of Use  
Variant peptides of calcitonin gene-related peptide alpha (αCGRP), calcitonin gene-related peptide beta (βCGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high...
9969803 Monoclonal antibodies that inhibit the Wnt signaling pathway and methods of production and use thereof  
Monoclonal antibodies against LRP6 and that block the Wnt signaling pathway are disclosed. Methods of production and use thereof are also disclosed.
US20180127637 METHODS OF ENHANCING OIL RECOVERY  
Methods of using compositions containing highly water soluble CO2-generating compounds for injection into subterranean formations for enhancing oil recovery from reservoirs therein. The...
9957305 Anti-C. difficile toxin antibodies and associated methods  
Embodiments of the invention are directed to a composition comprising a recombinant protein in soluble form wherein said recombinant protein comprises a portion of the Clostridium difficile toxin...
9950037 Enhancing progenitor cell numbers  
Therapies using IL-18 alone or in combination with IL-7 for rebuilding weakened immune systems by increasing progenitor cell yields from bone marrow stem cells and/or increasing stem cell...
US20180105865 MICRORNA EXPRESSION PROFILE ASSOCIATED WITH PANCREATIC CANCER  
Methods are provided for diagnosing whether a subject has, or is at risk of developing pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological...
US20180090837 RADIO FREQUENCY SCANNER  
A radio frequency (RF) scanner system provided with a multi-axis articulated robot and a sensor suite positioned on a first end of the multi-axis articulated robot. The sensor suite is provided...
9925209 Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same  
Compositions containing conjugates of heparosan polymer with at least one drug are disclosed, along with methods of production and use thereof.
US20180071726 Methods of Treatment and Use of Spent Equilibrium Catalyst  
Disclosed is a method of treating spent equilibrium catalyst (ECAT) for reuse, in which a quantity of spent ECAT comprising hydrophilic particles with differing levels of metal contamination is...
9902690 Ethoxylated surfactants  
The present invention provides sulfur- or selenium-containing compounds comprising hydrophobic moieties and ethoxylated ester or ethoxylated amide moieties such that the compounds have surfactant...
US20180044743 DROSOPHILA MODEL OF HUMAN CERVICAL CANCER  
Disclosed is a transgenic Drosophila model of human papillomavirus-mediated cancer. Also disclosed is a method for screening a candidate therapeutic for Human papillomavirus-induced cell...
US20180038870 DIAGNOSTIC METHOD FOR PEDIATRIC ACUTE-ONSET NEUROPSYCHIATRIC SYNDROME (PANS) AND PEDIATRIC AUTOIMMUNE NEUROPSYCHIATRIC DISORDER ASSOCIATED WITH STREPTOCOCCI INFECTION (PANDAS)  
The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or...
9887309 Photovoltaic lead-salt semiconductor detectors  
Disclosed is at least one embodiment of an infrared (IR) photovoltaic (PV) detector, comprising a IV-VI Lead (Pb)-salt layer disposed on a substrate and a charge-separation-junction (CSJ)...
9885072 High molecular weight heparosan polymers and methods of production of use thereof  
High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
9874301 Vibration reducing pipe junction  
A t-junction for use in a pipe manifold of a pumping system for supplying a fracturing fluid to well head.
US20180009036 METHODS OF SYNTHESIZING DENDRITIC GOLD NANOPARTICLES  
Methods of synthesizing gold nanodendrites (AuNDs) using amines, such as long chain amines, as a structural directing agent are disclosed. Degree of branching (DB) of the AuNDs can be tuned by...
9862748 Peptide compounds and methods of production and use thereof  
Peptide compounds based on the CAP37 (cationic antimicrobial protein of Mr 37 kDa) protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of...
US20180003653 METHODS OF DETERMINING SHALE PORE CONNECTIVITY  
A method of using NMR to estimate pore connectivity in a shale formation by estimating organic pore connectivity in a first sample of the shale formation and inorganic pore connectivity in a...
9850479 Method and apparatus for sampling macromolecules from a biological specimen  
Apparatus and methods for laser ablation sampling, electrophoretic extraction from the laser plume, electrophoretic transport to a container, and capture of macromolecules of interest. In certain...
US20170354476 SURGICAL CLEANING TOOL, SYSTEM, AND METHOD  
A surgical cleaning tool and method of cleaning a surgical tool. The surgical cleaning tool includes a shaft, a handle and an end portion. The shaft has a distal end and a proximal end. The handle...
9839690 Singlet oxygen-labile linkers and methods of production and use thereof  
Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at...
US20170348264 Glutamate Treatment of Cardiovascular Disorders  
Compositions and methods for treating various cardiovascular disorders include targeted delivery of glutamate for impairing a targeted portion of the autonomic nervous system (ANS). Targeted...
9804171 Diagnostic method for pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (PANDAS)  
The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or...
9778357 Cylindrical polarimetric phased array radar  
A method of collecting data using a polarimetric phased array antenna is described. The method includes directing electromagnetic signals to selected panels of an array of panels so as to transmit...
9777052 R-spondin variants, compositions, and methods of use  
R-spondin variants comprising a ZNRF3 binding region of a first R-spondin and an LGR4 binding region of a second R-spondin are disclosed. Cell culture media and compositions containing the...
US20170260231 Substrates and Inhibitors of Prolyl Oligopeptidase and Methods of Use Thereof  
Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders...
US20170252454 Heparosan Polymers and Methods of Making and Using Same for the Enhancement of Therapeutics  
Compositions, methods, and systems are disclosed for the development and use of heparosan as a therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior...
US20170247732 Methods of Producing Testosteronan Polymers Using Testosteronan Synthase  
Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-α1,4-D-GlcNAc-α1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes...
9744235 Treatment of cardiovascular disorders with targeted nanoparticles  
Methods for treating various cardiovascular disorders include targeted delivery of calcium ions for permanently impairing a portion of the autonomic nervous system (ANS). Targeted delivery may be...
US20170236447 PRONUNCIATION AID  
The present disclosure provides methods, tools, kits and electronic systems for transcribing non-Chinese language sounds into sound-associated Chinese language characters. The methods, tools, kits...
9735955 Optical cryptography systems and methods  
Systems and methods for sharing data between a first node and second node are disclosed. The methods may include sharing a first initialization vector between a first node and a second node using...
US20170226490 HIGH ISOMEROHYDROLASE ACTIVITY MUTANTS OF MAMMALIAN RPE65  
Mutant mammalian RPE65 proteins and portions thereof, and nucleic acids encoding the mutants, for use in treating a condition related to retinal degeneration in a subject, the mutant mammalian...
US20170216581 Cardiac Neuromodulation and Methods of Using Same  
A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the...
US20170214214 HYBRID SEMICONDUCTOR LASER ABSENT A TOP SEMICONDUCTOR CLADDING LAYER  
In at least one embodiment, a semiconductor laser is constructed to have a waveguide core including an active region, a top cladding, and a bottom cladding. The top cladding is positioned above...
US20170208040 OPTICAL CRYPTOGRAPHY SYSTEMS AND METHODS  
Systems and methods for sharing data between a first node and second node are disclosed. The methods may include sharing a first initialization vector between a first node and a second node using...
US20170198325 HIGH MOLECULAR WEIGHT HEPAROSAN POLYMERS AND METHODS OF PRODUCTION OF USE THEREOF  
High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
US20170190803 Heparosan-Based Biomaterials and Coatings and Methods of Production and Use Thereof  
Biomaterial compositions that include an isolated heparosan polymer are disclosed, as well as kits containing such biomaterial compositions and methods of producing and using such biomaterial...
9695427 Methods of producing testosteronan polymers using testosteronan synthase  
Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-α1,4-D-GlcNAc-α1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes...
9688722 Substrates and inhibitors of prolyl oligopeptidase and methods of use  
Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders...
9687559 Heparosan polymers and methods of making and using same for the enhancement of therapeutics  
The present invention includes compositions, methods, and systems for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or vehicle...
9683933 Method and apparatus for detecting an analyte  
Disclosed herein are methods and mid-IR detection apparatus to measure analytes in gas or liquid phase. Solid state cooling of a crystalline lattice is effectively achieved with the controlled...
9675662 Compositions for inhibition of RNA polymerase I and methods of production and use thereof  
Compositions for inhibition of RNA Polymerase I include peptides of Rpa43. Methods of production and use thereof are also disclosed.
9663585 Anti-DCLK1 monoclonal antibodies and methods of production and use thereof  
Monoclonal antibodies against DCLK1 and conjugates containing these monoclonal antibodies are disclosed. Methods of producing and using these monoclonal antibodies are also disclosed.
US20170140645 Traffic monitoring system  
An automated computerized system comprises a computer system executing traffic monitoring software. The traffic monitoring software reads data corresponding to a magnetic field of a first vehicle...