Patents and Patent Applications from University of Oklahoma


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US20190345493 ANTI-ARID3A TREATMENTS FOR INFLAMMATORY DISORDERS  
Antisense compounds for suppressing expression of ARTD3a are disclosed, as well as pharmaceutical compositions containing same and methods of producing and using same. The antisense compounds can...
US20190336593 CLOSTRIDIUM DIFFICILE IMMUNOGENIC COMPOSITIONS AND METHODS OF USE  
An immunogenic composition containing a Clostridium difficile (C. difficile) surface polysaccharide II (PSII) or an immunogenic portion thereof; and an α-galactosylceramide (α-GC) or analog or...
US20190336491 PHENYLQUINOLINE COMPOSITIONS FOR TREATMENT OF OCULAR DISORDERS AND CONDITIONS  
Compositions containing a phenylquinoline derivative compound having peroxisome proliferator-activated receptor a (PPARα) agonistic activity, and methods of their use in enhancing PPARα activity...
US20190336226 TRAINING SYSTEM FOR ROBOT-ASSISTED LAPAROSCOPIC SURGERY  
A training system for robot-assisted laparoscopic surgery is described. The training system includes a surgeon console in operative communication with a medical surgical robot, comprising (1) a...
10464983 Variants of adrenomedullin and calcitonin gene-related peptide and methods of use  
Variant peptides of calcitonin gene-related peptide alpha (αCGRP), calcitonin gene-related peptide beta (βCGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high...
US20190328785 FLT3-BINDING CHIMERIC ANTIGEN RECEPTORS, CELLS, AND USES THEREOF  
A chimeric antigen receptor (CAR) comprising (1) an extracellular portion of Fms-related tyrosine kinase 3 ligand (FLT3L) that binds to Fms-related tyrosine kinase 3 (FLT3), (2) a transmembrane...
US20190290903 System and Method of Electric-Induced Acoustic Tomography for Electrotherapy Monitoring  
A method and system for monitoring an electrotherapy treatment applied to a subject in need of such therapy. An ultrasound transducer array is positioned adjacent a tissue of the subject to which...
10398668 Glutamate treatment of cardiovascular disorders  
Compositions and methods for treating various cardiovascular disorders include targeted delivery of glutamate for impairing a targeted portion of the autonomic nervous system (ANS). Targeted...
US20190263862 Methods and Compositions for Treating Diseases and Conditions Associated with Gonadotropin Releasing Hormone Receptor  
The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor...
10392642 High molecular weight heparosan polymers and methods of production and use thereof  
High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
US20190255088 BIOCOMPATIBLE ORGANO-INORGANIC NANOCOMPOSITES  
Disclosed is an organo-inorganic nanocomposite (OINC) and a method of use thereof, the OINC containing a lipid membrane component made of a cationic lipid, a fusogenic co-lipid, and a pore forming...
US20190250126 NANOPORE ANALYSIS OF GLYCOSAMINOGLYCAN COMPOSITIONS  
In one aspect, methods of biomolecular analysis are described herein. Briefly, a method comprises providing a composition comprising glycosaminoglycans and contacting the composition with a...
US20190249523 Enhancing Productivity of Subterranean Formations  
The disclosure is directed to a method, and system for analyzing a subterranean formation for designing an oil field service to be completed in a borehole of the subterranean formation for...
10377941 Stabilized carbon nanotube suspensions  
Stable CNT dispersions having a combination of polymeric dispersants, including at least one first dispersant and at least one second dispersant, wherein the second dispersant is stable under...
US20190234638 Monitoring System for Residential HVAC Systems  
A system and method for controlling HVAC equipment in a residential setting. The system may include an outdoor temperature sensor positioned to measure outdoor temperatures, an indoor air...
10359379 Methods of determining shale pore connectivity  
A method of using NMR to estimate pore connectivity in a shale formation by estimating organic pore connectivity in a first sample of the shale formation and inorganic pore connectivity in a...
US20190218603 MICRORNA EXPRESSION SIGNATURES FOR DOUBLECORTIN-LIKE KINASE 1 (DCLK1) ACTIVITY  
Primer and/or probe sets and arrays for determining microRNA (miRNA) expression signatures that are specific to doublecortin-like kinase 1 (DCLK1) activity, and methods of their use, are disclosed.
US20190203966 Flow Device and Control System and Methods for HVAC System Monitoring  
Flow device systems for use in an HVAC system (“HVAC”) are described. The system may include a controller receiving sensor signals including differential pressure, valve commands, fan/pump speed,...
10330663 System and method for measuring separation rate of water from water-in-crude oil emulsions  
System and method relates to measuring separation rate of water from water-in-crude oil emulsions at elevated temperature. The system includes an electrolytic interface (conductivity) cell...
US20190170760 DIAGNOSTIC METHOD FOR PEDIATRIC ACUTE-ONSET NEUROPSYCHIATRIC SYNDROME (PANS) AND PEDIATRIC AUTOIMMUNE NEUROPSYCHIATRIC DISORDER ASSOCIATED WITH STREPTOCOCCI INFECTION (PANDAS)  
The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or...
US20190170695 System and Method for Nanoscale Photoacoustic Tomography  
A method and system of nanoscale photoacoustic tomography (nPAT) for non-invasive three-dimensional mapping and characterization of fine cellular structures (such as but not limited to organelles,...
US20190140364 Dual-Linear-Polarized, Highly-Isolated, Crossed-Dipole Antenna and Antenna Array  
A dual linear polarized dipole antenna (and arrays of such antennas) having high isolation between ports. The antenna may include a pair of crossed (collocated) bent (angled) dipole antenna...
US20190133939 Nanocrystal Microparticles of Poorly Soluble Drugs and Methods of Production and Use Thereof  
Microparticulate drug compositions comprising aggregated nanocrystals of poorly soluble drugs are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug...
10283658 Interband cascade devices  
Photovoltaic (PV) and photodetector (PD) devices, comprising a plurality of interband cascade (IC) stages, wherein the IC stages comprise an absorption region with a type-I superlattice and/or a...
10279180 Cardiac neuromodulation and methods of using same  
A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the...
US20190126164 Multiple-Effect Vapor Chamber Distillation System and Methods of Use  
A distillation system having a plurality of chambers, an input conduit connected to each chamber to deliver an aqueous fluid to each chamber; a pressure reducing valve connected to the input...
10273517 Methods of producing testosteronan polymers using testosteronan synthase  
Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-α1,4-D-GlcNAc-α1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes...
10258613 Compositions for treating retinal degeneration and methods of production and use thereof  
Compositions for use in methods of treating and/or inhibiting a pathologic ocular condition, as well as methods of producing and using same, are disclosed.
US20190085235 METHODS OF ENHANCING OIL RECOVERY  
Disclosed are compositions containing highly water soluble CO2-generating compounds and their use for injection into subterranean formations for enhancing oil recovery therefrom. The subterranean...
10228376 Diagnostic method for pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (PANDAS)  
The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or...
10226523 Clostridium difficile vaccine and methods of use  
Embodiments of the present disclosure include vaccine compositions comprising a TcdB toxin or toxoid derived therefrom. The TcdB toxin may be derived from a hypervirulent strain of C. difficile. A...
US20190055551 NOVEL pRNA THREE-WAY JUNCTIONS  
Three-way junction (3WJ) RNA scaffolds derived from phi29, M2, SF5, and GA1 pRNAs and which have high stability are described. The pRNA 3WJ scaffolds can be used to form compounds, conjugates,...
US20190054210 PRODUCING BONE TISSUE ENGINEERED CONSTRUCTS  
A process for producing a bone construct, including the steps of providing a perfusion bioreactor having an inlet and an outlet; providing the perfusion bioreactor with a seeded scaffold...
10206904 Licofelone derivatives and methods of use  
Derivatives of licofelone for the treatment of chronic inflammatory diseases and epithelial cancers associated with chronic inflammation are disclosed. The agents target mPGES-1 and 5-LOX.
US20190048287 SURFACTANT MICROEMULSIONS  
The present invention relates to microemulsions and methods of preparing and using the microemulsions.
US20190047988 2,4-DIAMINOQUINAZOLINE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS  
Novel 2,4-diaminoquinazoline derivatives are disclosed. The compounds can be used in treating diseases and conditions which are associated with abnormal cell function related to endoplasmic...
US20190038579 SHIKIMATE ANALOGUES AND METHODS OF USE  
The present disclosure, in at least certain embodiments, is directed to shikimate (shikimic acid) analogues and compositions thereof, kits which contain the shikimate analogues or compositions...
US20190017374 Generating Spectral Responses of Materials  
In one non-limiting embodiment, the present disclosure is directed to a controller having a memory; and a processor coupled to the memory and configured to: cause a neural network to receive...
10174077 Method of inhibiting activity of cell surface fibroblast activation protein alpha  
The presently disclosed inventive concept(s) include inhibitors of antiplasmin cleaving enzyme (APCE) and fibroblast activation protein alpha (FAP) which can be used in various therapies related...
US20190002508 PORE-MODIFIED GRAM-NEGATIVE BACTERIA AND USES THEREOF  
Mutants of Gram-negative bacteria having outer membranes comprising modified OrbA nanopores absent an N-terminal plug domain are disclosed. The modified OrbA nanopores confer the outer membrane of...
10166386 Implantable electrode assembly  
An electrode assembly includes a retainer, a flexible sheath, and an electrode. The retainer may include a plurality of clasping arms. The retainer is movable to an open position and a closed...
US20180369270 HEPAROSAN-POLYPEPTIDE AND HEPAROSAN-POLYNUCLEOTIDE DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME  
Compositions containing conjugates of heparosan polymer with at least one drug are disclosed, along with methods of production and use thereof.
10155789 Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof  
Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders...
US20180344167 X-Ray-Induced Acoustic Computed Tomography (XACT) Breast Imaging  
An X-ray computed tomography breast imaging method comprises positioning a patient such that a breast of the patient is disposed adjacent to an ultrasound detector comprising a transducer array,...
US20180338951 TREATMENTS FOR ARTERIAL STIFFENING, HYPERTENSION AND ANTI-AGING  
Compositions and methods for the treatment and amelioration of arterial stiffness, hypertension, and/or arterial aging in a subject. In certain embodiments, the active agents of the compositions...
US20180328900 OPEN TUBULAR LIQUID CHROMATOGRAPHY APPARATUS AND METHODS OF USE  
An open tubular chromatography apparatus has at least one liquid chromatography capillary, a valve in fluid communication with the liquid chromatography capillary for adding a sample to the liquid...
US20180319863 ANTI-HLA ASSAY AND METHODS  
Anti-MHC assay methodologies utilize functionally active, recombinantly produced, truncated individual soluble MHC trimolecular complexes that are linked to a substrate.
US20180312552 Pneumolysin Mutants and Methods of Use Thereof  
The present disclosure provides, in various embodiments, immunogenic mutants of cholesterol-dependent cytolysins, such as pneumolysin, which have reduced hemolytic activity and reduced...
US20180306805 COMPARATIVE LIGAND MAPPING FROM MHC CLASS I POSITIVE CELLS  
Compositions that include isolated, functionally active, recombinantly produced class I HLA trimolecular complexes that include epitopes unique to breast cancer cells are disclosed.
10109754 Photovoltaic lead-salt detectors  
Disclosed is at least one embodiment of an infrared (IR) photovoltaic (PV) detector, comprising a IV-VI Lead (Pb)-salt layer disposed on a substrate and a charge-separation-junction (CSJ)...